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1. Global DNA methylation and telomere length as markers of accelerated aging in people living with HIV and non-alcoholic fatty liver disease

Author

Elena Moreno, Javier Martínez-Sanz, Rosa Martín-Mateos, Jorge Díaz-Álvarez, Sergio Serrano-Villar, Diego Burgos-Santamaría, Laura Luna, María Jesús Vivancos, Ana Moreno-Zamora, María Jesús Pérez-Elías, Santiago Moreno, Fernando Dronda, María Luisa Montes, and Matilde Sánchez-Conde

Subjects
DNA methylation, MAFLD, PLWH, Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Metabolic-dysfunction-associated fatty liver disease (MAFLD) is a comorbidity that generally increases in people living with HIV (PLWH). This condition is usually accompanied by persistent inflammation and premature immune system aging. In this prospective cohort study, we describe a straightforward methodology for quantifying biomarkers of aging, such as DNA methylation and telomere length, in PLWH and in the context of another relevant condition, such as MAFLD. Fifty-seven samples in total, thirty-eight from PLWH and nineteen from non-PLWH participants with or without MAFLD, were obtained and subjected to DNA extraction from peripheral blood mononuclear cells (PBMCs). Global DNA methylation and telomere length quantification were performed using an adapted enzyme-linked immunosorbent assay (ELISA) and qPCR, respectively. The quantification results were analysed and corrected by clinically relevant variables in this context, such as age, sex, and metabolic syndrome. Our results show an increased association of these biomarkers in PLWH regardless of their MAFLD status. Thus, we propose including the quantification of these age-related factors in studies of comorbidities. This will allow a better understanding of the effect of comorbidities of HIV infection and MAFLD and prevent their effects in these populations in the future.

Published
2023
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2. Evaluación cuantitativa y cualitativa de la satisfacción en la enseñanza de la Patología en estudiantes de medicina en una universidad compleja chilena

Author

Cristina Durán Reyes, Carolina Delgado Schneider, Santiago Martínez Riquelme, Jorge Maturana Barrera, Claudia Constanzo Valdebenito, Diego Burgos Burgos, Valeria Dassori Walker, Anai Vallejos, and Pía Villalobos Huerta

Subjects
Aprendizaje, Educación Médica, Educación en salud, Estudiantes del área de la salud, Motivación, Patología, Medicine, Education
Abstract

Las asignaturas de Patología general y Anatomía patológica son impartidas durante el quinto y sexto semestre de la carrera de Medicina de la Universidad de Concepción. En estas se utiliza un estilo de enseñanza tipo aula invertida y se realiza una actividad práctica de “Diseño de Casos Clínico-Patológicos” (DCCP), iniciada en sala de patología quirúrgica, donde los estudiantes vivencian en forma real el trabajo del anatomopatólogo en grupos de 3 a 4 personas, realizando desde el dictado macroscópico hasta el diagnóstico microscópico, con una presentación final del caso a estudiantes y docentes. Se realizó un estudio observacional analítico transversal a una muestra de 87 estudiantes que cursaron ambas asignaturas. Se efectuó un análisis descriptivo cuantitativo y un método cualitativo de análisis de contenido, codificándose y clasificándose las respuestas de 2 instrumentos. La satisfacción general de la actividad DCCP fue de 82,4%, siendo percibida como innovadora y útil para el desarrollo de habilidades y aprendizajes teóricos de patología, que prepara a los alumnos de mejor manera para enfrentar los desafíos del mundo real como profesionales de la salud. No se debe olvidar la importancia de considerar las preferencias y necesidades de los estudiantes al diseñar estrategias de enseñanza. La evaluación cualitativa de la actividad DCCP y de las asignaturas entregó valiosa información para un mejoramiento continuo; reafirmando la importancia de incorporar éstas en las evaluaciones de prácticas docentes. Se concluye que la actividad práctica DCCP ayuda de mejor forma a los estudiantes de medicina a entender los aspectos macroscópicos y microscópicos de la Anatomía Patológica; superando incluso al aula invertida. La combinación de enfoques centrados en el alumno, trabajo en entornos reales, un apoyo docente adecuado y material de estudio de calidad puede conducir a una experiencia de aprendizaje más efectiva y satisfactoria para los estudiantes en estas disciplinas.

Published
2024
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3. A gut microbiome signature for HIV and metabolic dysfunction-associated steatotic liver disease

Author

Javier Martínez-Sanz, Alba Talavera-Rodríguez, Jorge Díaz-Álvarez, Marta Rosas Cancio-Suárez, Juan Miguel Rodríguez, Claudio Alba, María Luisa Montes, Rosa Martín-Mateos, Diego Burgos-Santamaría, Santiago Moreno, Sergio Serrano-Villar, and Matilde Sánchez-Conde

Subjects
HIV, MASLD, NAFLD, gut microbiome, microbiome, Immunologic diseases. Allergy, RC581-607
Abstract

IntroductionMetabolic dysfunction-associated steatotic liver disease (MASLD), has emerged as an increasingly recognized problem among people living with HIV (PLWH). The gut-liver axis is considered to be strongly implicated in the pathogenesis of MASLD. We aimed to characterize the gut microbiota composition in PLWH and MASLD and compare it with that of two control groups: PLWH without MASLD and individuals with MASLD without HIV infection.MethodsWe collected clinical data and stool samples from participants. Bacterial 16S rRNA genes were amplified, sequenced, and clustered into operational taxonomic unit. Alpha diversity was studied by Shannon and Simpson indexes. To study how different the gut microbiota composition is between the different groups, beta diversity estimation was evaluated by principal coordinate analysis (PCoA) using Bray-Curtis dissimilarity. To further analyze differences in microbiome composition we performed a linear discriminant analysis (LDA) effect size (LEfSe).ResultsWe included 30 HIV+MASLD+, 30 HIV+MASLD- and 20 HIV-MASLD+ participants. Major butyrate producers, including Faecalibacterium, Ruminococcus, and Lachnospira dominated the microbiota in all three groups. Shannon’s and Simpson’s diversity metrics were higher among MASLD+ individuals (Kruskal-Wallis p = 0.047). Beta diversity analysis showed distinct clustering in MASLD-, with MASLD+ participants overlapping regardless of HIV status (ADONIS significance

Published
2023
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4. Sentiment Analysis of News Articles in Spanish using Predicate Features

Author

Antonio Tamayo, Julián Arias Londoño, Diego Burgos, and Gabriel Quiroz

Subjects
sentiment analysis, linguistic features, socio-politics, news articles, support vector machines, naïve bayes, dimension reduction, Romanic languages, PC1-5498, Philology. Linguistics, P1-1091
Abstract

The automatic prediction of the course of action of agents involved in social or economic trends is an imperative challenge nowadays. However, it is a difficult task because stance or opinion is often spread throughout long, complex texts, such as news articles. The current study tests sentence predicates as features to automatically determine the writer’s stance in news articles. We capture the semantics and stance of the text by encoding features such as the attribute of copulative sentences, the predicate of transitive sentences, adjectival phrases, and the section of the article. Under the assumption that these features are informative enough to model the semantics of the text, each word sequence is disambiguated and assigned a sentiment value using weighting rules. Different experiments were run using either SentiWordNet and ML-Senticon to determine words’ sentiment. Feature vectors are automatically built to populate a database that is tested using two machine learning algorithms. An efficiency of 69% was achieved using a SVM with Gaussian kernel along with a feature selection strategy. This score outperformed the bag-of-words baseline in 12%. These results are promising considering that the sentiment analysis is performed on very complex texts written in Spanish.

Published
2019
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5. Decreased relative risk of pneumococcal pneumonia during the last decade, a nested case-control study

Author

Carlos M. Luna, Laura Pulido, Michael S. Niederman, Alberto Casey, Diego Burgos, Sebastián D. Leiva Agüero, Alejandra Grosso, Evangelina Membriani, Andrea C. Entrocassi, Marcelo Rodríquez Fermepin, Carlos A. Vay, Susana Garcia, and Angela Famiglietti

Subjects
Community acquired pneumonia, Streptococcus pneumoniae, Urinary antigen test, Prevalence, Pneumococcal conjugate vaccine, Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Streptococcus pneumoniae (SP) is one of the most common pathogens of Community-Acquired Pneumonia (CAP), but recent reports suggest that its incidence may be declining in relation to the use of the conjugate 13-valent pneumococcal vaccine in children. We compared the result of the immunochromatographic SP urinary antigen test (SPUAT) and clinical outcomes in patients with CAP admitted in two periods of time: 2001–2002(CAP1) and 2015–2016(CAP2). Methods This was a matched nested case-control study of two prospectively recorded cohorts of patients admitted with CAP, with SPUAT and blood culture performed in all patients. CAP2 cases and CAP1 controls were matched for age ± 4 years, sex, and Pneumonia Severity Index (PSI) score ± 10 points. Odds ratios (OR) for having SPUAT positive was estimated by conditional logistic regression. A multivariate model assessed the contribution of individual variables. Results Four hundred ninety-eight patients were recruited; 307 during the CAP1 and 191 during the CAP2 periods. Comparing both periods we observed differences, in age, PSI score, and the percentage of smokers, outpatients, previously immunized with pneumococcal vaccine, and positive SPUAT. On the other hand, mortality, admission from nursing homes, pneumococcal bacteremia and hospital admission were not different. After matching, pneumonia due to SP per the SPUAT was observed in 34(23.4%) of CAP1 and in 12(8.3%) of CAP2 patients (p

Published
2018
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6. Bilateral diaphragmatic paralysis after an unusual physical effort

Author

Cora Legarreta, Javier Brea Folco, Diego Burgos, Santiago Arce, and Carlos Luna

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Diaphragmatic paralysis is an uncommon cause of pulmonary dysfunction and can occur after traumatic phrenic nerve injury. Penetrating and blunt trauma to the neck is the most recognized mechanism of injury being stretching of the nerves very uncommon. We report a case of a 39-year-old man with bilateral diaphragmatic paralysis due to violent stretching of the phrenic nerves. Clinical features and diagnosis methods are also reviewed. Keywords: Diaphragmatic paralysis, Phrenic nerve injury

Published
2018
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7. Impaired esophageal motor function in eosinophilic esophagitis

Author

Cecilio Santander, Carlos M. Chavarría-Herbozo, Irene Becerro-González, and Diego Burgos-Santamaría

Subjects
Esofagitis eosinofílica, Motilidad esofágica, Distensibilidad esofágica, Manometría de alta resolución, Manometría ambulatoria, Planimetría por impedancia, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Eosinophilic esophagitis is a chronic immunoallergic inflammatory disease of the esophagus that represents a major cause of digestive morbidity among the pediatric and young adult populations. Despite the fact that key symptoms in adults include dysphagia and food impaction, many patients lack structural changes in the esophagus to account for their complaints, which suggests the presence of underlying motor disorders and esophageal distensibility impairment. In the last few years the esophageal motility of these patients has been studied using various approaches, most particularly high-resolution manometry, ambulatory manometry, and impedance planimetry. This review focuses on the most relevant findings and scientific evidence regarding esophageal motor disorders in eosinophilic esophagitis.

Published
2015

8. Normal values for water-perfused esophageal high-resolution manometry

Author

Diego Burgos-Santamaría, Almudena Marinero, Carlos Miguel Chavarría-Herbozo, Teresa Pérez-Fernández, Teresa R. López-Salazar, and Cecilio Santander

Subjects
Manometría esofágica de alta resolución, Valores de normalidad, Unión gastroesofágica, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background: Normal values for water-perfused esophageal high-resolution manometry have still not been established in our environment, despite its generalized use and the recommendation to determine reference values for each Motility Unit based on their equipment. Normal values established with solid-state high-resolution manometry are currently being used as reference values for water-perfused high-resolution manometry. Objectives: To obtain normal values for water-perfused esophageal high-resolution manometry, based on the esophageal motility analysis of healthy subjects. Methods: 16 healthy volunteers without history of digestive complaints or esophageal symptoms were included. 22-channel water-perfused high-resolution manometry was performed. Results: Normal values were calculated as 5th-95th percentile ranges for the following parameters; upper esophageal sphincter resting pressure (UESRP) (40-195 mmHg); upper esophageal sphincter residual pressure (UESResP) (30-115 mmHg), contractile front velocity (CFV) (2.4-7.1 cm/s), distal contractile integral (DCI) (285-2820 mmHg.s.cm), distal contraction latency (DL) (6.1-10.9 s), intrabolus pressure (IBP) (7-19 mmHg), integrated relaxation pressure (IRP 4s) (2-20 mmHg), lower esophageal sphincter resting pressure (LESRP) (5-54 mmHg), esophageal shortening (Es) (0.3-1.3 cm) and lower esophageal sphincter lift (LESL) (0,1-1,2 cm). Conclusion: Normal values for the most important parameters (such as IRP 4s, DL and CFV), obtained using a 22-channel water-perfused system resemble previously published data from other perfusion devices. However, there exist small but significant variations compared with values established with solid-state high-resolution manometry. Thus, when using water-perfused catheters, caution is required when normative values are used that were established with solid-state catheters.

Published
2015

9. MobiSpaces: An Architecture for Energy-Efficient Data Spaces for Mobility Data.

Author

Christos Doulkeridis, Georgios M. Santipantakis, Nikolaos Koutroumanis, George Makridis, Vasilis Koukos, George S. Theodoropoulos, Yannis Theodoridis, Dimosthenis Kyriazis, Pavlos Kranas, Diego Burgos, Ricardo Jiménez-Peris, Mariana M. G. Duarte, Mahmoud Attia Sakr, Esteban Zimányi, Anita Graser, Clemens Heistracher, Kristian Torp, Ioannis Chrysakis, Theofanis Orphanoudakis, Evgenia Kapassa, Marios Touloupou, Jürgen Neises, Petros Petrou, Sophia Karagiorgou, Rosario Catelli, Domenico Messina, Marcelo Corrales Compagnucci, and Matteo Falsetta

Published
2023
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10. Empirical Second-Line Therapy in 5000 Patients of the European Registry on Helicobacter pylori Management (Hp-EuReg)

Author

Fiorinni, Giulia, Saracino, Ilaria Maria, Carrasco, Manuel Pabon, Huerga, Alma Keco, Almajano, Enrique Alfaro, Martinez Dominguez, Samuel Jesus, Galan, Horacio Alonso, Velayos, Benito, Sadornil, Carmen Dueñas, Botargues Bote, Jose Maria, Gonzalez-Cordero, Pedro Luis, Areia, Miguel, Gomez Rodriguez, Blas Jose, Pellicano, Rinaldo, Nuñez, Óscar, Franceschi, Francesco, Alekseenko, Sergey, Perona, Monica, Abdulkhakov, Rustam, Dominguez-Cajal, Manuel, Notari, Pedro Almela, Camarero, Judith Gomez, Moreno, Manuel Jimenez, Algaba, Alicia, Bermejo, Fernando, Tejada, Javier Tejedor, Susanibar, Elida Oblitas, Boltin, Doron, Georgopoulos, Sotirios, OMorain, Colm, Qasim, Asghar, Beales, Ian, Bakulina, Natalia, Fadeenko, Galina, Malfertheiner, Peter, Rosania, Rosa, Ilchishina, Tatiana, Bogomolov, Pavel, Bakulin, Igor, Zaytsev, Oleg, Gravina, Antonietta Gerarda, Romano, Marco, Di Leo, Alfredo, Losurdo, Giuseppe, Grigorieva, Ludmila, Guillena, Pedro Delgado, Marusic, Marinko, Jurcic, Dragan, Dekhnich, Natalia Nikolaevna, Iyo, Eduardo, de la Peña Negro, Luisa Carmen, Baryshnikova, Natalia, Bakanova, Natalia, Simsek, Halis, Simsek, Cem, Gridnyev, Oleksiy, Fernandez-Bermejo, Miguel, Angueira, Teresa, Ruiz-Zorrilla Lopez, Rafael, Gomez, Barbara, Kovacheva-Slavova, Mila, Lahat, Adi, Alcedo, Javier, Campillo, Ana, Belousova, Liya Nikolaevna, Villarroya, Ramon Pajares, Ljubicic, Neven, Nikolic, Marko, González-Santiago, Jesús M., Santamaría, Diego Burgos, Pakhomova, Anna, Sekulic-Spasic, Izabela, Ghisa, Matteo, Farinati, Fabio, Sagdati, Sabir Irfan, Panic, Nikola, Heluwaert, Frederic, Amorena, Edurne, Moreira, Leticia, Esparrach, Gloria Fernandez, Plotnikova, Ekaterina Yuryevna, Kukla, Michal, Kamburov, Victor, Lamuela Calvo, Luis Javier, Rankovic, Ivan, Lavín, Antonio Cuadrado, Lazaro, Yolanda Arguedas, Carrera Agnieszka Dobrowolska, Victor Gonzalez, Eder, Piotr, Kononova, Alla, Nyssen, Olga P., Vaira, Dino, Pérez Aísa, Ángeles, Rodrigo, Luis, Castro-Fernandez, Manuel, Jonaitis, Laimas, Tepes, Bojan, Vologzhanina, Liudmila, Caldas, María, Lanas, Angel, Lucendo, Alfredo J., Bujanda, Luis, Ortuño, Juan, Barrio, Jesús, Huguet, Jose M., Voynovan, Irina, Lasala, Jorge Perez, Sarsenbaeva, Aiman Silkanovna, Fernandez-Salazar, Luis, Molina-Infante, Javier, Jurecic, Natasa Brglez, Gasbarrini, Antonio, Kupčinskas, Juozas, Bordin, Dmitry, Marcos-Pinto, Ricardo, Lerang, Frode, Leja, Marcis, Buzas, Gyorgy M., Niv, Yaron, Rokkas, Theodore, Phull, Perminder, Smith, Sinead, Shvets, Oleg, Venerito, Marino, Milivojevic, Vladimir, Simsek, Ilkay, Lamy, Vincent, Bytzer, Peter, Boyanova, Lyudmila, Kunovský, Lumír, Beglinger, Christoph, Doulberis, Michael, Marlicz, Wojciech, Goldis, Adrian, Tonkić, Ante, Capelle, Lisette, Puig, Ignasi, Megraud, Francis, Morain, Colm O’, and Gisbert, Javier P.

Published
2022
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11. iHELP: Personalised Health Monitoring and Decision Support Based on Artificial Intelligence and Holistic Health Records.

Author

George Manias, Harm op den Akker, Ainhoa Azqueta-Alzúaz, Diego Burgos-Sancho, Nikola Dino Capocchiano, Borja Llobell Crespo, Athanasios Dalianis, Andrea Damiani, Krasimir Filipov, Giorgos Giotis, Maritini Kalogerini, Rostislav Kostadinov, Pavlos Kranas, Dimosthenis Kyriazis, Artitaya Lophatananon, Shwetambara Malwade, George Marinos, Fabio Melillo, Vicent Moncho Mas, Kenneth Muir, Marzena Nieroda, Antonio De Nigro, Claudia Pandolfo, Marta Patiño-Martínez, Florin Picioroaga, Aristodemos Pnevmatikakis, Shabbir Syed-Abdul, Tanja Tomson, Dilyana Vicheva, and Usman Wajid

Published
2021
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12. WED-172 Transaminase Pattern Over Time Is Not Associated with a More Aggressive Hepatic Evolution: Results from the AEEH Wilson Registry

Author

Berenguer, Marina, primary, García-Villarreal, Luis, additional, Olveira, Antonio, additional, Molina, Esther, additional, Planas, Jose María Moreno, additional, Romero-Gutiérrez, Marta, additional, Bandera, Jose Pinazo, additional, Masnou, Helena, additional, Iruzubieta, Paula, additional, Dieguez, Maria Luisa Gonzalez, additional, Ampuero, Javier, additional, Fernández, José Ramón, additional, Codoceo, Carolina Muñoz, additional, Almeida, Ana Arencibia, additional, Lorente, Sara, additional, Delgado, Manuel, additional, Santamaria, Diego Burgos, additional, Blasco, Víctor Manuel Vargas, additional, Cachero, Alba, additional, Guerra, Manuel Hernández, additional, Gómez-Camarero, Judith, additional, Morillas, Julia, additional, Ríos, María Lázaro, additional, Soria, Isabel Carmona, additional, Carrión, Gemma, additional, Bono, Ariadna, additional, Miralpeix, Anna, additional, Castellano, Pablo Alonso, additional, and Mariño, Zoe, additional

Published
2024
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16. EFOMP policy statement 18:Medical physics education for the non-physics healthcare professions

Author

Carmel J. Caruana, Richard A. Amos, Diego Burgos, Stan Heukelom, Marija Z. Jeremic, Petro Julkunen, Violeta Karenauskaite, Loredana Marcu, Emmanouil Papanastasiou, Csilla Pesznyak, Caruana, Carmel J, Amos, Richard A, Burgos, Diego, Heukelom, Stan, Jeremic, Marija Z, Julkunen, Petro, Karenauskaite, Violeta, Marcu, Loredana, Papanastasiou, Emmanouil, Pesznyak, Csilla, and VU University medical center

Subjects
EFOMP policy statement, medical physics curriculum development, Biophysics, General Physics and Astronomy, Radiology, Nuclear Medicine and imaging, General Medicine, non-physics healthcare professions, education of healthcare professions
Abstract

Refereed/Peer-reviewed Although Medical Physics educators have historically contributed to the education of the non-physics healthcare professions, their role was not studied in a systematic manner. In 2009, EFOMP set up a group to research the issue. In their first paper, the group carried out an extensive literature review regarding physics teaching for the non-physics healthcare professions. Their second paper reported the results of a pan-European survey of physics curricula delivered to the healthcare professions and a Strengths-Weaknesses-Opportunities-Threats (SWOT) audit of the role. The group’s third paper presented a strategic development model for the role, based on the SWOT data. A comprehensive curriculum development model was subsequently published, whilst plans were laid to develop the present policy statement. This policy statement presents mission and vision statements for Medical Physicists teaching non-physics users of medical devices and physical agents, best practices for teaching non-physics healthcare professionals, a stepwise process for curriculum development (content, method of delivery and assessment), and summary recommendations based on the aforementioned research studies.

Published
2023
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18. Main clinical characteristics and evolutionary events among patients suffering Wilson disease in Spain: first results from the Spanish Wilson registry

Author

Mariño, Zoe, primary, García-Villarreal, Luis, additional, Martin, Antonio Olveira, additional, Ampuero, Javier, additional, Berenguer, Marina, additional, Santamaria, Diego Burgos, additional, Fernández, José Ramón, additional, Moreno Planas, Jose María, additional, Ríos, María Lázaro, additional, Masnou, Helena, additional, Gonzalez Dieguez, Maria Luisa, additional, Bandera, Jose Pinazo, additional, Molina, Esther, additional, Guerra, Manuel Hernández, additional, de frutos, Concepción gonzalez, additional, Ruiz, Patricia Cordero, additional, Codoceo, Carolina Muñoz, additional, Lorente, Sara, additional, Cachero, Alba, additional, Delgado, Manuel, additional, Vargas Blasco, Víctor Manuel, additional, Gómez-Camarero, Judith, additional, Morillas, Julia, additional, Alarcon, Francisca Cuenca, additional, Samaniego, Luis Ibañez, additional, Fernandez-Bermejo, Miguel, additional, Álvarez-Suárez, Beatriz, additional, Iruzubieta, Paula, additional, Almeida, Ana Arencibia, additional, Miralpeix, Anna, additional, Castellano, Pablo Alonso, additional, and Castillo, Pilar, additional

Published
2023
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19. First nationwide genetic study on Wilson disease (Spanish Wilson registry): high diversity in mutations and in use of genetic evaluation, association with clinical data and influence on diagnosis and health costs

Author

Castellano, Pablo Alonso, primary, Mariño, Zoe, additional, Martin, Antonio Olveira, additional, Ampuero, Javier, additional, Berenguer, Marina, additional, Santamaria, Diego Burgos, additional, Fernández, José Ramón, additional, Moreno Planas, Jose María, additional, Ríos, María Lázaro, additional, Masnou, Helena, additional, Gonzalez Dieguez, Maria Luisa, additional, Bandera, Jose Pinazo, additional, Molina, Esther, additional, Guerra, Manuel Hernández, additional, de frutos, Concepción gonzalez, additional, Ruiz, Patricia Cordero, additional, Codoceo, Carolina Muñoz, additional, Lorente, Sara, additional, Cachero, Alba, additional, Delgado, Manuel, additional, Vargas Blasco, Víctor Manuel, additional, Gómez-Camarero, Judith, additional, Morillas, Julia, additional, Alarcon, Francisca Cuenca, additional, Samaniego, Luis Ibañez, additional, Fernandez-Bermejo, Miguel, additional, Álvarez-Suárez, Beatriz, additional, Iruzubieta, Paula, additional, Almeida, Ana Arencibia, additional, Miralpeix, Anna, additional, Castillo, Pilar, additional, and García-Villarreal, Luis, additional

Published
2023
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20. Lessons from population genomics for Wilson disease: Prevalence, penetrance of mutations, clinical implications and design of regional screening programmes

Author

Castellano, Pablo Alonso, primary, Mariño, Zoe, additional, Martin, Antonio Olveira, additional, Ampuero, Javier, additional, Berenguer, Marina, additional, Huarte Muniesa, Maria Pilar, additional, Santamaria, Diego Burgos, additional, Fernández, José Ramón, additional, Moreno Planas, Jose María, additional, Ríos, María Lázaro, additional, Masnou, Helena, additional, Gonzalez Dieguez, Maria Luisa, additional, Bandera, Jose Pinazo, additional, Molina, Esther, additional, Guerra, Manuel Hernández, additional, Romero-Gutiérrez, Marta, additional, Ruiz, Patricia Cordero, additional, Codoceo, Carolina Muñoz, additional, Lorente, Sara, additional, Cachero, Alba, additional, Delgado, Manuel, additional, Vargas Blasco, Víctor Manuel, additional, Gómez-Camarero, Judith, additional, Morillas, Julia, additional, Alarcon, Francisca Cuenca, additional, Samaniego, Luis Ibañez, additional, Fernandez-Bermejo, Miguel, additional, Álvarez-Suárez, Beatriz, additional, Iruzubieta, Paula, additional, Almeida, Ana Arencibia, additional, Miralpeix, Anna, additional, Castillo, Pilar, additional, and García-Villarreal, Luis, additional

Published
2023
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21. Endoscopy sleeve gastroplasty is an effective treatment in steatohepatitis patients: a prospective, multicenter, randomized trial

Author

Guerra, Javier Abad, primary, Llop, Elba, additional, Arias Loste, María Teresa, additional, Santamaria, Diego Burgos, additional, Martínez Porras, José Luis, additional, Graus, Javier, additional, Iruzubieta, Paula, additional, Antoran, Belén Ruiz, additional, Gomez, Manuel Romero, additional, Albillos, Agustin, additional, Crespo, Javier, additional, and Calleja Panero, José Luis, additional

Published
2023
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22. The new diagnostic criteria of portopulmonary hypertension identify a group of patients with cirrhosis at high risk of death

Author

Téllez, Luis, primary, Guerrero, Antonio, additional, Donate, Jesus, additional, Rodríguez-Gandía, Miguel Ángel, additional, del Prado, Susana, additional, Tenes, Andrés, additional, Martin-Mateos, Rosa, additional, Alonso, Rosario González, additional, Martinez, Javier, additional, González, Miguel García, additional, Sánchez-Aldehuelo, Rubén, additional, Santamaria, Diego Burgos, additional, Muños, Beatriz Mateos, additional, Guerrero, María Torres, additional, Lledo Navarro, Jose Luis, additional, and Albillos, Agustin, additional

Published
2023
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23. T2.1 - Design of Reference Architecture

Author

Pavlos Kranas, Javier Pereira, Fernando García Doval, Diego Burgos, Alejandro Ramiro, Raúl De Pablo, Rogelio Rodriguez, Francisco Nvara, Spencer Pablos, Jose Correas Remedios, Petros Petrou, Stavroula Iatropoulou, Theodora Anastasiou, Ioannis Chrysakis, Theofanis Orphanoudakis, Andreas Zalonis, Myroulla Drakos, Christoforos Pirillos, Christos Doulkeridis, Georgios M. Santipantakis, Nikolaos Koutroumanis, George Makridis, Vasilis Koukos, George S. Theodoropoulos, Yannis Theodoridis, Dimosthenis Kyriazis, Mariana Machado Garcez Duarte, Mahmoud Sakr, Esteban Zimanyi, Carlos Sanchez, Francesco D'Andria, Septimiu Nechifo, Cosmin Grigoras, Juergen Neises, Domenico Messina, Rosario Catelli, Petros Brimos, Kostas Nasias, Tiago Teixeira, Bruno Almeida, Pedro Malo, Nikolay Mehandjiev, Nadia Masood Khan, Matteo Falsetta, Anita Graser, Clemens Heistracher, Kristian Torp, Marcelo Corrales Compagnucci, and Sophia Karagiorgou

Subjects
Mobility, MobiSpaces, Reference Architecture, AI Edge Analytics, Data Governance, Data Management
Abstract

This is the first of the series of deliverables related to the activities of task T2.1 (“Design of Reference Architecture”). This deliverable specifies the system and software requirements of the MobiSpaces integrated solution, the analysis of the state-of-the-art approaches and the background technologies that the platform will be built upon, and the definition of the reference architecture of MobiSpaces, along with the detailed description of its software building blocks presented in a componentised manner.

Published
2023
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24. Global DNA methylation and telomere length as markers of accelerated ageing in non-alcoholic fatty liver disease patients with HIV infection

Author

Elena Moreno, Javier Martínez-Sanz, Rosa Martín-Mateos, Jorge Díaz-Álvarez, Sergio Serrano-Villar, Diego Burgos-Santamaría, Laura Luna, María Jesús Vivancos, Ana Moreno-Zamora, María Jesús Pérez-Elías, Santiago Moreno, Fernando Dronda, María Luisa Montes, and Matilde Sánchez-Conde

Abstract

Metabolic-dysfunction-associated fatty liver disease (MAFLD) is a comorbidity that generally increases in people living with HIV (PLWH). This condition is usually accompanied by persistent inflammation and premature immune system ageing. In this prospective cohort study, we describe a straightforward methodology for quantifying the effect of HIV on aging factors compared with other relevant conditions, such as MAFLD, by quantifying DNA methylation and telomere length. Fifty-seven samples in total, thirty-eight from HIV-infected and nineteen from HIV-uninfected participants with or without MAFLD, were obtained and subjected to DNA extraction from peripheral blood mononuclear cells (PBMCs). DNA methylation and telomere length quantification were performed using an adapted enzyme-linked immunosorbent assay (ELISA) and qPCR, respectively. The quantification results were analysed and corrected by clinically relevant variables in this context, such as age, sex, and metabolic syndrome. The results showed an increased association with these age-acceleration markers in individuals with HIV, who were also diagnosed with MAFLD. This highlights the importance of HIV infection and MAFLD conditions in the biological ageing process in PLWH, and the fact that these markers of ageing can be measured through DNA methylation and telomere length quantification. Thus, we propose including these quantifications in studies of comorbidities to better understand them and potentially prevent their effects in this population.

Published
2023
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27. Empirical rescue treatment of Helicobacter pylori infection in third and subsequent lines: 8-year experience in 2144 patients from the European Registry on H. pylori management (Hp-EuReg)

Author

Diego Burgos-Santamaría, Olga P Nyssen, Antonio Gasbarrini, Dino Vaira, Ángeles Pérez-Aisa, Luís Rodrigo, Rinaldo Pellicano, Alma Keco-Huerga, Manuel Pabón-Carrasco, Manuel Castro-Fernandez, Doron Boltin, Jesus Barrio, Perminder Phull, Juozas Kupcinskas, Laimas Jonaitis, Inmaculada Ortiz-Polo, Bojan Tepes, Alfredo J Lucendo, José María Huguet, Miguel Areia, Natasa Brglez Jurecic, Maja Denkovski, Luís Bujanda, June Ramos-San Román, Antonio Cuadrado-Lavín, Judith Gomez-Camarero, Manuel Alfonso Jiménez Moreno, Angel Lanas, Samuel Jesús Martinez-Dominguez, Enrique Alfaro, Ricardo Marcos-Pinto, Vladimir Milivojevic, Theodore Rokkas, Marcis Leja, Sinead Smith, Ante Tonkić, György Miklós Buzás, Michael Doulberis, Marino Venerito, Frode Lerang, Dmitry S Bordin, Vincent Lamy, Lisette G Capelle, Wojciech Marlicz, Daniela Dobru, Oleksiy Gridnyev, Ignasi Puig, Francis Mégraud, Colm O'Morain, Javier P Gisbert, and Gastroenterology & Hepatology

Subjects
drug resistance, Helicobacter pylori, proton pump inhibition, Settore MED/12 - GASTROENTEROLOGIA, Gastroenterology, antibiotic therapy, antibiotics
Abstract

ObjectiveTo evaluate the use, effectiveness and safety ofHelicobacter pyloriempirical rescue therapy in third and subsequent treatment lines in Europe.DesignInternational, prospective, non-interventional registry of the clinical practice of European gastroenterologists. Data were collected and quality reviewed until October 2021 at Asociación Española de Gastroenterología-Research Electronic Data Capture. All cases with three or more empirical eradication attempts were assessed for effectiveness by modified intention-to-treat and per-protocol analysis.ResultsOverall, 2144 treatments were included: 1519, 439, 145 and 41 cases from third, fourth, fifth and sixth treatment lines, respectively. Sixty different therapies were used; the 15 most frequently prescribed encompassed >90% of cases. Overall effectiveness remained ConclusionEmpirical rescue treatment in third and subsequent lines achieved suboptimal effectiveness in most European regions. Only quadruple bismuth-metronidazole-tetracycline (10-day single-capsule or 14-day traditional scheme) and triple amoxicillin-levofloxacin therapies reached acceptable outcomes in some settings. Compliance with empirical therapy optimisation principles is still poor 5 years after clinical practice guidelines update.Trial registration numberNCT02328131.

Published
2022

28. Empirical Second-Line Therapy in 5000 Patients of the European Registry on Helicobacter pylori Management (Hp-EuReg)

Author

Nyssen, Olga P., primary, Vaira, Dino, additional, Pérez Aísa, Ángeles, additional, Rodrigo, Luis, additional, Castro-Fernandez, Manuel, additional, Jonaitis, Laimas, additional, Tepes, Bojan, additional, Vologzhanina, Liudmila, additional, Caldas, María, additional, Lanas, Angel, additional, Lucendo, Alfredo J., additional, Bujanda, Luis, additional, Ortuño, Juan, additional, Barrio, Jesús, additional, Huguet, Jose M., additional, Voynovan, Irina, additional, Lasala, Jorge Perez, additional, Sarsenbaeva, Aiman Silkanovna, additional, Fernandez-Salazar, Luis, additional, Molina-Infante, Javier, additional, Jurecic, Natasa Brglez, additional, Areia, Miguel, additional, Gasbarrini, Antonio, additional, Kupčinskas, Juozas, additional, Bordin, Dmitry, additional, Marcos-Pinto, Ricardo, additional, Lerang, Frode, additional, Leja, Marcis, additional, Buzas, Gyorgy M., additional, Niv, Yaron, additional, Rokkas, Theodore, additional, Phull, Perminder, additional, Smith, Sinead, additional, Shvets, Oleg, additional, Venerito, Marino, additional, Milivojevic, Vladimir, additional, Simsek, Ilkay, additional, Lamy, Vincent, additional, Bytzer, Peter, additional, Boyanova, Lyudmila, additional, Kunovský, Lumír, additional, Beglinger, Christoph, additional, Doulberis, Michael, additional, Marlicz, Wojciech, additional, Goldis, Adrian, additional, Tonkić, Ante, additional, Capelle, Lisette, additional, Puig, Ignasi, additional, Megraud, Francis, additional, Morain, Colm O’, additional, Gisbert, Javier P., additional, Fiorinni, Giulia, additional, Saracino, Ilaria Maria, additional, Carrasco, Manuel Pabon, additional, Huerga, Alma Keco, additional, Almajano, Enrique Alfaro, additional, Martinez Dominguez, Samuel Jesus, additional, Galan, Horacio Alonso, additional, Velayos, Benito, additional, Sadornil, Carmen Dueñas, additional, Botargues Bote, Jose Maria, additional, Gonzalez-Cordero, Pedro Luis, additional, Gomez Rodriguez, Blas Jose, additional, Pellicano, Rinaldo, additional, Nuñez, Óscar, additional, Franceschi, Francesco, additional, Alekseenko, Sergey, additional, Perona, Monica, additional, Abdulkhakov, Rustam, additional, Dominguez-Cajal, Manuel, additional, Notari, Pedro Almela, additional, Camarero, Judith Gomez, additional, Moreno, Manuel Jimenez, additional, Algaba, Alicia, additional, Bermejo, Fernando, additional, Tejada, Javier Tejedor, additional, Susanibar, Elida Oblitas, additional, Boltin, Doron, additional, Georgopoulos, Sotirios, additional, OMorain, Colm, additional, Qasim, Asghar, additional, Beales, Ian, additional, Bakulina, Natalia, additional, Fadeenko, Galina, additional, Malfertheiner, Peter, additional, Rosania, Rosa, additional, Ilchishina, Tatiana, additional, Bogomolov, Pavel, additional, Bakulin, Igor, additional, Zaytsev, Oleg, additional, Gravina, Antonietta Gerarda, additional, Romano, Marco, additional, Di Leo, Alfredo, additional, Losurdo, Giuseppe, additional, Grigorieva, Ludmila, additional, Guillena, Pedro Delgado, additional, Marusic, Marinko, additional, Jurcic, Dragan, additional, Dekhnich, Natalia Nikolaevna, additional, Iyo, Eduardo, additional, de la Peña Negro, Luisa Carmen, additional, Baryshnikova, Natalia, additional, Bakanova, Natalia, additional, Simsek, Halis, additional, Simsek, Cem, additional, Gridnyev, Oleksiy, additional, Fernandez-Bermejo, Miguel, additional, Angueira, Teresa, additional, Ruiz-Zorrilla Lopez, Rafael, additional, Gomez, Barbara, additional, Kovacheva-Slavova, Mila, additional, Lahat, Adi, additional, Alcedo, Javier, additional, Campillo, Ana, additional, Belousova, Liya Nikolaevna, additional, Villarroya, Ramon Pajares, additional, Ljubicic, Neven, additional, Nikolic, Marko, additional, González-Santiago, Jesús M., additional, Santamaría, Diego Burgos, additional, Pakhomova, Anna, additional, Sekulic-Spasic, Izabela, additional, Ghisa, Matteo, additional, Farinati, Fabio, additional, Sagdati, Sabir Irfan, additional, Panic, Nikola, additional, Heluwaert, Frederic, additional, Amorena, Edurne, additional, Moreira, Leticia, additional, Esparrach, Gloria Fernandez, additional, Plotnikova, Ekaterina Yuryevna, additional, Kukla, Michal, additional, Kamburov, Victor, additional, Lamuela Calvo, Luis Javier, additional, Rankovic, Ivan, additional, Lavín, Antonio Cuadrado, additional, Lazaro, Yolanda Arguedas, additional, Carrera Agnieszka Dobrowolska, Victor Gonzalez, additional, Eder, Piotr, additional, and Kononova, Alla, additional

Published
2022
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30. Empirical rescue treatment of

Author

Diego, Burgos-Santamaría, Olga P, Nyssen, Antonio, Gasbarrini, Dino, Vaira, Ángeles, Pérez-Aisa, Luís, Rodrigo, Rinaldo, Pellicano, Alma, Keco-Huerga, Manuel, Pabón-Carrasco, Manuel, Castro-Fernandez, Doron, Boltin, Jesus, Barrio, Perminder, Phull, Juozas, Kupcinskas, Laimas, Jonaitis, Inmaculada, Ortiz-Polo, Bojan, Tepes, Alfredo J, Lucendo, José María, Huguet, Miguel, Areia, Natasa Brglez, Jurecic, Maja, Denkovski, Luís, Bujanda, June, Ramos-San Román, Antonio, Cuadrado-Lavín, Judith, Gomez-Camarero, Manuel Alfonso, Jiménez Moreno, Angel, Lanas, Samuel Jesús, Martinez-Dominguez, Enrique, Alfaro, Ricardo, Marcos-Pinto, Vladimir, Milivojevic, Theodore, Rokkas, Marcis, Leja, Sinead, Smith, Ante, Tonkić, György Miklós, Buzás, Michael, Doulberis, Marino, Venerito, Frode, Lerang, Dmitry S, Bordin, Vincent, Lamy, Lisette G, Capelle, Wojciech, Marlicz, Daniela, Dobru, Oleksiy, Gridnyev, Ignasi, Puig, Francis, Mégraud, Colm, O'Morain, Javier P, Gisbert, and Milica, Bjelakovic

Abstract

To evaluate the use, effectiveness and safety ofInternational, prospective, non-interventional registry of the clinical practice of European gastroenterologists. Data were collected and quality reviewed until October 2021 at Asociación Española de Gastroenterología-Research Electronic Data Capture. All cases with three or more empirical eradication attempts were assessed for effectiveness by modified intention-to-treat and per-protocol analysis.Overall, 2144 treatments were included: 1519, 439, 145 and 41 cases from third, fourth, fifth and sixth treatment lines, respectively. Sixty different therapies were used; the 15 most frequently prescribed encompassed90% of cases. Overall effectiveness remained90% in all therapies. Optimised treatments achieved a higher eradication rate than non-optimised (78% vs 67%, p0.0001). From 2017 to 2021, only 44% of treatments other than 10-day single-capsule therapy used high proton-pump inhibitor doses and lasted ≥14 days. Quadruple therapy containing metronidazole, tetracycline and bismuth achieved optimal eradication rates only when prescribed as third-line treatment, either as 10-day single-capsule therapy (87%) or as 14-day traditional therapy with tetracycline hydrochloride (95%). Triple amoxicillin-levofloxacin therapy achieved 90% effectiveness in Eastern Europe only or when optimised. The overall incidence of adverse events was 31%.Empirical rescue treatment in third and subsequent lines achieved suboptimal effectiveness in most European regions. Only quadruple bismuth-metronidazole-tetracycline (10-day single-capsule or 14-day traditional scheme) and triple amoxicillin-levofloxacin therapies reached acceptable outcomes in some settings. Compliance with empirical therapy optimisation principles is still poor 5 years after clinical practice guidelines update.NCT02328131.

Published
2022

32. Subjective-wellbeing at the face of natural disasters. The case of the 2010 earthquake in Chile

Author

César Salazar Espinoza and Diego Burgos Lopez

Subjects
Economic growth, natural disaster, History, Face (sociological concept), lcsh:Human settlements. Communities, lcsh:HT51-65, lcsh:HD72-88, lcsh:Economic growth, development, planning, atural disaster, subjective well-being, earthquake, happiness, Natural disaster, life satisfaction
Abstract

It well known that natural disasters have a significant effect on material well-being. The purpose of this study is to explore the effect of natural disasters on the individual life satisfaction. For this purpose, we use data from the 2010 LAPOP survey for Chile, which contains a series of questions regarding the earthquake of the same year that affected the country. After estimating an ordered Probit model, results show a negative effect on the subjective-wellbeing of the affected population, particularly those who report damage to their home or/and an injury.

Published
2020
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33. Effects of HIV Infection in Plasma Free Fatty Acid Profiles among People with Non-Alcoholic Fatty Liver Disease

Author

Javier Martínez-Sanz, María Visitación Calvo, Sergio Serrano-Villar, María Luisa Montes, Rosa Martín-Mateos, Diego Burgos-Santamaría, Jorge Díaz-Álvarez, Alba Talavera-Rodríguez, Marta Rosas, Santiago Moreno, Javier Fontecha, Matilde Sánchez-Conde, Instituto de Salud Carlos III, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), and Agencia Estatal de Investigación (España)

Subjects
non-alcoholic fatty liver disease, HIV, lipidomics, fatty acids, Lipidomics, General Medicine, Fatty acids, Non-alcoholic fatty liver disease
Abstract

This article belongs to the Section Infectious Diseases., Despite its high prevalence, the mechanisms underlying non-alcoholic fatty liver disease (NAFLD) in people living with HIV (PLWH) are still unclear. In this prospective cohort study, we aim to evaluate differences in plasma fatty acid profiles between HIV-infected and HIV-uninfected participants with NAFLD. We included participants diagnosed with NAFLD, both HIV-infected and HIV-uninfected. Fatty acid methyl esters were measured from plasma samples. Ratios ([product]/[substrate]) were used to estimate desaturases and elongases activity. We used linear regression for adjusted analyses. We included 31 PLWH and 22 HIV-uninfected controls. We did not find differences in the sum of different types of FA or in FA with a greater presence of plasma. However, there were significant differences in the distribution of some FA, with higher concentrations of ALA, trans-palmitoleic, and behenic acids, and a lower concentration of lignoceric acid in PLWH. PLWH had lower C24:0/C22:0 and C16:0/C14:0 ratios, which estimates the activity of elongases ELOVL1 and ELOVL6. Both groups had similar fatty acid distribution, despite differences in traditional risk factors. PLWH had a lower proportion of specific ratios that estimate ELOVL1 and ELOVL6 activity, which had been previously described for other inflammatory conditions, such as psoriasis., This work was supported by the Instituto de Salud Carlos III project PI17/01717 Plan Estatal de Investigación Científica y Técnica y de Innovación 2013–2016. Co-funded by European Regional Development Fund “a way to make Europe”, and by the Spanish Ministry of Science, Innovation and Universities (Project PDI2020-114821RB-I00 MCIN/AEI/10.13039/501100011033).

Published
2022

34. Accumulation of dihydrosphingolipids and neutral lipids is related to steatosis and fibrosis damage in human and animal models of non-alcoholic fatty liver disease

Author

Bohdan Babiy, Bruno Ramos-Molina, Luis Ocaña, Silvia Sacristán, Diego Burgos-Santamaría, Javier Martínez-Botas, Gemma Villa-Turégano, Rebeca Busto, Cristian Perna, M. Dolores Frutos, Agustín Albillos, and Óscar Pastor

Abstract

BackgroundDihydrosphingolipids are lipid molecules biosynthetically related to ceramides. An increase in ceramides is associated with enhanced fat storage in the liver and inhibition of their synthesis is reported to prevent the appearance of steatosis in animal models. However, the precise association of dihydrosphingolipids with non-alcoholic fatty liver disease (NAFLD) is yet to be established. We employed a diet-induced NAFLD mouse model to study the association between this class of compounds and disease progression.MethodsMice were fed a high-fat diet enriched in cholesterol and supplemented with glucose and fructose up to 40 weeks. A mouse subgroup was treated with carbon tetrachloride to accelerate fibrosis development. Animals were sacrificed at different time-points to reproduce the full spectrum of histological damage found in human disease, including steatosis (NAFL) and steatohepatitis (NASH) with and without significant fibrosis. Blood and liver tissue samples were obtained from patients (n=195) whose NAFLD severity was assessed histologically. Lipidomic analysis was performed using liquid chromatography-tandem mass spectrometry.ResultsTriglyceride, cholesterol ester and dihydrosphingolipid levels were increased in the liver of model mice in association with the degree of steatosis. Dihydroceramide concentrations increased with the histological severity of the disease in liver samples of mice (0.024 ± 0.003 vs 0.049 ± 0.005, non-NAFLD vs NASH-fibrosis, pConclusionsDihydrosphingolipids accumulate in the liver in response to increased free fatty acid overload and are correlated with progressive histological damage in NAFLD. The increase in dihydrosphingolipids is related to upregulation of hepatic expression of enzymes involved in de novo synthesis of ceramides.HIGHLIGHTSNeutral lipids and dihydrosphingolipids accumulate in liver in correlation with the histological severity of NAFLD in both mice and humans.The ceramide pathway is stimulated to alleviate the free fatty acid excess in liver of NAFLD models.Appearance of significant fibrosis is associated with reduced concentrations of neutral lipids but not dihydrosphingolipids in a mouse model of NAFLD.

Published
2022
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35. Architectural Patterns for Data Pipelines in Digital Finance and Insurance Applications

Author

Diego Burgos, Pavlos Kranas, Ricardo Jimenez-Peris, and Juan Mahíllo

Abstract

This chapter presents a holistic solution to the issue of data pipelining that ingest data as fast as needed, works with current and historic data, handles efficiently aggregates, and can handle them at any scale. This holistic solution minimizes the Total Cost of Ownership (TCO) of the storage systems needed to develop a data pipeline and minimizes the execution time of the data pipeline. In this direction, the chapter presents a range of architectural patterns for data pipelining and illustrates how the presented solution boosts their simplification and optimization.

Published
2022
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36. Simplifying and Accelerating Data Pipelines in Digital Finance and Insurance Applications

Author

Pavlos Kranas, Diego Burgos, Ricardo Jimenez-Peris, and Juan Mahíllo

Abstract

To process their ever-increasing massive data, financial and insurance organizations are developing and deploying data pipelines. However, state-of-the-art data management platforms have limitations in handling many and complex pipelines that blend different kinds of data stores. This chapter introduces a novel Big Data database, namely the LeanXcale database, which enables the development and management of complex pipelines in a scalable fashion. Specifically, the presented database reduces data access time independently of data size and allows for efficient process parallelization. This combination of capabilities helps to reduce the data pipeline complexity and the total cost of ownership of pipeline management. Moreover, it unveils new ways of generating value with new use cases that were previously not possible.

Published
2022
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37. Global multi-stakeholder endorsement of the MAFLD definition

Author

Nahum Méndez-Sánchez, Elisabetta Bugianesi, Robert G Gish, Frank Lammert, Herbert Tilg, Mindie H Nguyen, Shiv K Sarin, Núria Fabrellas, Shira Zelber-Sagi, Jian-Gao Fan, Gamal Shiha, Giovanni Targher, Ming-Hua Zheng, Wah-Kheong Chan, Shlomo Vinker, Takumi Kawaguchi, Laurent Castera, Yusuf Yilmaz, Marko Korenjak, C Wendy Spearman, Mehmet Ungan, Melissa Palmer, Mortada El-Shabrawi, Hans-Juergen Gruss, Jean-François Dufour, Anil Dhawan, Heiner Wedemeyer, Jacob George, Luca Valenti, Yasser Fouad, Manuel Romero‐Gomez, Mohammed Eslam, Maria Lorena Abate, Bahaa Abbas, Ahmed Amr Abbassy, Waleed Abd El Ghany, Amira Abd Elkhalek, Emad Abd ElMajeed, Mohammad Abdalgaber, Mohamed AbdAllah, Marwa Abdallah, Nourhan Abdallah, Shereen Abdelaleem, Yasser Abdelghani, Wael Abdelghany, Safaa Mohamed Abdelhalim, Wafaa Abdelhamid, Nehal Abdelhamid, Nadia A. Abdelkader, Elsayed Abdelkreem, Aly Mohamed Abdelmohsen, Awny Ali Abdelrahman, Sherief M Abd-elsalam, Doaa Abdeltawab, Abdulbaset Abduh, Nada Abdulhakam, Maheeba Abdulla, Navid Abedpoor, Ludovico Abenavoli, Fredrik Åberg, Omala Ablack, Mostafa Abo elftouh, Yousry Esam-Eldin Abo-Amer, Ashraf Aboubkr, Alaa Aboud, Amr M. Abouelnaga, Galal A. Aboufarrag, Ashraf Aboutaleb, Leticia Abundis, Gupse Adalı, Enrique Adames, Leon Adams, Danjuma Adda, Noor Adel, Nada Adel, Muhammad Adel Sayed, Taiba Jibril Afaa, Nawal Afredj, Gulnara Aghayeva, Alessio Aghemo, Carlos A. Aguilar-Salinas, Golo Ahlenstiel, Walid Ahmady, Wafaa Ahmed, Amira Ahmed, Samah Nasser Ahmed, Heba Mostafa Ahmed, Rasha Ahmed, Elmar Aigner, Mesut Akarsu, Maisam Akroush, Umit Akyuz, Mamun Al Mahtab, Tahani Al Qadiri, Yusriya Al Rawahi, Razzaq AL rubaee, Muna Al Saffar, Shahinul Alam, Zaid Al-Ani, Agustín Albillos, Mohamed Alboraie, Said Al-Busafi, Mohamed Al-Emam, Jawaher Alharthi, Kareem Ali, Basma Abdelmoez Ali, Mohammad Ali, Raja Affendi Raja Ali, Anna Alisi, Ali Raad AL-Khafaji, Maryam Alkhatry, Rocio Aller, Yahya Almansoury, Khalid Al-Naamani, Alaa Alnakeeb, Anna Alonso, Saleh A. Alqahtani, Leina Alrabadi, Khalid Alswat, Mahir Altaher, Turki Altamimi, Jose Altamirano, Mario R. Alvares-da-Silva, Elsragy Adel M. Aly, Amgad Alzahaby, Ahmed Alzamzamy, Keisuke Amano, Maysa A. Amer, Mona A. Amin, Sayed A. Amin, Ashraf A. Amir, Javier Ampuero, Noha Anas, Pietro Andreone, Soa Fy Andriamandimby, Mahmoud Anees, Peltec Angela, Manal Antonios, Wael Arafat, Jose Moreno Araya, Juan Armendariz-Borunda, Matthew J. Armstrong, Hassan Ashktorab, Patricia Aspichueta, Fathia Assal, Mira Atef, Dina Attia, Hoda Atwa, Reham Awad, Mohyeldeen Abd Elaziz Awad, Sally Awny, Obafemi Awolowo, Yaw Asante Awuku, Ibrahim Ayada, Than Than Aye, Sherif Ayman, Hedy Ayman, Hesham Ayoub, Hosny M. Azmy, Romiro P. Babaran, Omneya Badreldin, Ahmed Badry, İbrahim Halil Bahçecioğlu, Amira Bahour, Jiajia Bai, Yasemin Balaban, Muthuswamy Balasubramanyam, Khaled Bamakhrama, Jesus M Banales, Babu Bangaru, Jianfeng Bao, Jorge Suazo Barahona, Salma Barakat, Sandra Maria Barbalho, Bikwa Barbra, Beatriz Barranco, Francisco Barrera, Ulrich Baumann, Shamardan Bazeed, Eva Bech, Aourarh Benayad, Andreas Benesic, David Bernstein, Fernando Bessone, Susie Birney, Cyrille Bisseye, Martin Blake, Bilal Bobat, Leonilde Bonfrate, Dmitry S Bordin, Francisco Bosques-Padilla, Jerome Boursier, Boushab Mohamed Boushab, David Bowen, Patricia Medina Bravo, Paul N Brennan, Bisi Bright, Ilse Broekaert, Xabier Buque, Diego Burgos-Santamaría, Julio Burman, Luca Busetto, Chris D. Byrne, Patricia Anne I. Cabral-Prodigalidad, Guillermo Cabrera-Alvarez, Wei Cai, Francesca Cainelli, Ali Riza Caliskan, Ali Canbay, Ana Cano-Contreras, Hai-Xia Cao, Zhujun Cao, Andres Carrion, Francesca Carubbi, Teresa Casanovas, Marlen Ivón Castellanos Fernández, Jin Chai, Siew Pheng Chan, Phunchai Charatcharoenwitthaya, Norberto Chavez-Tapia, Kazuaki Chayama, Jinjun Chen, Lin Chen, Zhong-Wei Chen, Huiting Chen, Sui-Dan Chen, Qiang Chen, Yaxi Chen, Gang Chen, En-Quang Chen, Fei Chen, Pei-Jer Chen, Robert Cheng, Wendy Cheng, Jack Tan Wei Chieh, Imad Chokr, Evangelos Cholongitas, Ashok Choudhury, Abhijit Chowdhury, Evaristus Sunday Chukwudike, Stefano Ciardullo, Michelle Clayton, Karine Clement, Marie Michelle Cloa, Cecilia Coccia, Cristina Collazos, Massimo Colombo, Arif Mansur Cosar, Helma Pinchemel Cotrim, Joris Couillerot, Alioune Coulibaly, Gonzalo Crespo, Javier Crespo, Maria Cruells, Ian Homer Y. Cua, Hesham K. Dabbous, George N Dalekos, Patricia D'Alia, Li Dan, Viet Hang Dao, Mostafa Darwish, Christian Datz, Milagros B Davalos-Moscol, Heba Dawoud, Blanca Olaechea de Careaga, Robert de Knegt, Victor de Ledinghen, Janaka de Silva, Nabil Debzi, Marie Decraecker, Elvira Del Pozo, Teresa C Delgado, Manuel Delgado-Blanco, Łukasz Dembiński, Adilson Depina, Moutaz Derbala, Hailemichael Desalegn, Christèle Desbois-Mouthon, Mahmoud Desoky, Anouk Dev, Agostino Di Ciaula, Moisés Diago, Ibrahima Diallo, Luis Antonio Díaz, Melisa Dirchwolf, Paola Dongiovanni, Andrriy Dorofeyev, Xiaoguang Dou, Mark W. Douglas, Michael Doulberis, Cecil K. Dovia, Adam Doyle, Ivana Dragojević, Joost PH Drenth, Xuefei Duan, Audrius Dulskas, Dan L Dumitrascu, Oliver Duncan, Vincent Dusabejambo, Rev. Shem N.A. Dwawhi, Sho Eiketsu, Doaa El Amrousy, Ahmed El Deeb, Ghada El Deriny, Hesham Salah El Din, Salwa El Kamshishy, Mohamed El Kassas, Maissa El Raziky, Osama A Elagamy, Wafaa Elakel, Dina Elalfy, Hanaa Elaraby, Heba ElAwady, Reda Elbadawy, Hanaa Hassan Eldash, Manal S. Eldefrawy, Carol Lezama Elecharri, Amel Elfaramawy, Mohammed Elfatih, Mahmoud Elfiky, Mohamed Elgamsy, Mohamed Elgendy, Mohamed A. El-Guindi, Nagi Elhussieny, Ahmed Maher Eliwa, Zeineb Elkabbany, Hesham El-Khayat, Nehal M. El-Koofy, Alaa Elmetwalli, Amr Elrabat, Fathiya El-Raey, Fatma Elrashdy, Medhat Elsahhar, Esraa M. Elsaid, Shimaa Elsayed, Hany Elsayed, Aly Elsayed, Amr M. Elsayed, Hamdy Elsayed, Magdy El-Serafy, Ahmed M. Elsharkawy, Reem Yehia Elsheemy, Eman Elsayed Elshemy, Sara Elsherbini, Naglaa Eltoukhy, Reda Elwakil, Ola Emad, Shaimaa Emad, Mohamed Embabi, Ilkay Ergenç, Tatiana Ermolova, Gamal Esmat, Doaa M. Esmat, Enrique Carrera Estupiñan, Said Ettair, Tcaciuc Eugen, Mohammed Ezz-Eldin, Lidia Patricia Valdivieso Falcón, Yu-Chen Fan, Samah Fandari, Mahmoud Farag, Taghreed Mohamed Farahat, Eman M. Fares, Michael Fares, Eduardo Fassio, Hayam Fathy, Dina Fathy, Wael Fathy, Soheir Fayed, Dan Feng, Gong Feng, Miguel Fernández-Bermejo, Cristina Targa Ferreira, Javier Díaz Ferrer, Alastair Forbes, Rabab Fouad, Hanan M. Fouad, Tove Frisch, Hideki Fujii, Shuhei Fukunaga, Shinya Fukunishi, Hacer Fulya, Masato Furuhashi, Yasmine Gaber, Augusto Jose G. Galang, Jacqueline Cordova Gallardo, Rocío Galloso, Mahmoud Gamal, Reham Gamal, Hadeel Gamal, Jian Gan, Anar Ganbold, Xin Gao, George Garas, Tony Garba, Miren García-Cortes, Carmelo García-Monzón, Javier García-Samaniego, Amalia Gastaldelli, Manuel Gatica, Elizabeth Gatley, Tamar Gegeshidze, Bin Geng, Hasmik Ghazinyan, Salma Ghoneem, Luca Giacomelli, Gianluigi Giannelli, Edoardo G. Giannini, Matthew Giefer, Pere Ginès, Marcos Girala, Pablo J Giraudi, George Boon-Bee Goh, Ahmed Ali Gomaa, Benbingdi Gong, Dina Hilda C. Gonzales, Humberto C. Gonzalez, Maria Saraí Gonzalez-Huezo, Isabel Graupera, Ivica Grgurevic, Henning Grønbæk, Xuelian Gu, Lin Guan, Ibrahima Gueye, Alice Nanelin Guingané, Ozen Oz Gul, Cuma Bulent Gul, Qing Guo, Pramendra Prasad Gupta, Ahmet Gurakar, Juan Carlos Restrepo Gutierrez, Ghada Habib, Azaa Hafez, Emilia Hagman, Eman Halawa, Osama Hamdy, Abd Elkhalek Hamed, Dina H. Hamed, Saeed Hamid, Waseem Hamoudi, Yu Han, James Haridy, Hanan Haridy, David C H Harris Harris, Michael Hart, Fuad Hasan, Almoutaz Hashim, Israa Hassan, Ayman Hassan, Essam Ali Hassan, Adel Ahmed Hassan, Magda Shehata Hassan, Fetouh Hassanin, Alshymaa Hassnine, John Willy Haukeland, Amr Ismael M. Hawal, Jinfan He, Qiong He, Yong He, Fang-Ping He, Mona Hegazy, Adham Hegazy, Osama Henegil, Nelia Hernández, Manuel Hernández-Guerra, Fatima Higuera-de-la-Tijera, Ibrahim Hindy, Keisuke Hirota, Lee Chi Ho, Alexander Hodge, Mohamed Hosny, Xin Hou, Jiao-Feng Huang, Yan Huang, Zhifeng Huang, Yuan Huang, Ang Huang, Xiao-Ping Huang, Sheng Hui-ping, Bela Hunyady, Mennatallah A. Hussein, Osama Hussein, Shahinaz Mahmoud Hussien, Luis Ibáñez-Samaniego, Jamal Ibdah, Luqman Ibrahim, Miada Ibrahim, Ibrahim Ibrahim, Maria E. Icaza-Chávez, Sahar Idelbi, Ramazan Idilman Idilman, Mayumi Ikeda, Giuseppe Indolfi, Federica Invernizzi, Iram Irshad, Hasan Mohamed Ali Isa, Natacha Jreige Iskandar, Abdulrahman Ismaiel, Mariam Ismail, Zulkifli Ismail, Faisal Ismail, Hideki Iwamoto, Kathryn Jack, Rachael Jacob, Fuad Jafarov, Wasim Jafri, Helen Jahshan, Prasun K Jalal, Ligita Jancoriene, Martin Janicko, Hiruni Jayasena, Meryem Jefferies, Vivekanand Jha, Fanpu Ji, Yaqiu Ji, Jidong Jia, Changtao Jiang, Ni Jiang, Zong-zhe Jiang, Xing Jin, Yi Jin, Xu Jing, Qian Jingyu, Maia Jinjolava, FX Himawan Haryanto Jong, Alina Jucov, Ibecheole Julius, Mona Kaddah, Yoshihiro Kamada, Abobakr kamal, Enas Mohamed Kamal, Ashraf Sayed Kamel, Jia-Horng Kao, Maja Karin, Thomas Karlas, Mohammad Kashwaa, Leolin Katsidzira, Eda Kaya, M.Azzam Kayasseh, Bernadette Keenan, Caglayan Keklikkiran, William Keml, Deia K. Khalaf, Rofida Khalefa, Sherin Khamis, Doaa Khater, Hamed khattab, Anatoly Khavkin, Olga Khlynova, Nabil Khmis, Nazarii Kobyliak, Apostolos Koffas, Kazuhiko Koike, Kenneth Y.Y. Kok, Tomas Koller, Narcisse Patrice Komas, Nataliya V. Korochanskaya, Yannoula Koulla, Shunji Koya, Colleen Kraft, Bledar Kraja, Marcin Krawczyk, Mohammad Shafi Kuchay, Anand V Kulkarni, Ashish Kumar, Manoj Kumar, Sulaiman Lakoh, Philip Lam, Ling Lan, Naomi F. Lange, Kamran Bagheri Lankarani, Nicolas Lanthier, Kateryna Lapshyna, Sameh A. Lashen, Konang Nguieguia Justine Laure, Leonid Lazebnik, Didier Lebrec, Samuel S. Lee, Way Seah Lee, Yeong Yeh Lee, Diana Julie Leeming, Nathalie Carvalho Leite, Roberto Leon, Cosmas Rinaldi Adithya Lesmana, Junfeng Li, Qiong Li, Jun Li, Yang-Yang Li, Yufang Li, Lei Li, Min Li, Yiling li, Huiqing Liang, Tang Lijuan, Seng Gee Lim, Lee-Ling Lim, Shumei Lin, Han-Chieh Lin, Rita Lin, Rania Lithy, Yaru Liu, Yuanyuan Liu, Xin Liu, Wen-Yue Liu, Shourong Liu, Ken Liu, Tian Liu, Amedeo Lonardo, Mariana Bravo López, Eva López-Benages, Patricio Lopez-Jaramillo, Huimin Lu, Lun Gen Lu, Yan Lu, John Lubel, Rashid Lui, Iulianna Lupasco, Elena Luzina, Xiao-Hui Lv, Kate Lynch, Hong-Lei Ma, Mariana Verdelho Machado, Nonso Maduka, Katerina Madzharova, Russellini Magdaong, Sanjiv Mahadeva, Amel Mahfouz, Nik Ritza Kosai Nik Mahmood, Eman Mahmoud, Mohamed Mahrous, Rakhi Maiwall, Ammar Majeed, Avik Majumdar, Loey Mak, Madiha M Maklouf, Reza Malekzadeh, Claudia Mandato, Alessandra Mangia, Jake Mann, Hala Hussien Mansour, Abdellah Mansouri, Alessandro Mantovani, Jun qian Mao, Flor Maramag, Giulio Marchesini, Claude Marcus, Rui António Rocha Tato Marinho, Maria L Martinez-Chantar, Antonieta A. Soares Martins, Rana Marwan, Karen Frances Mason, Ghadeer Masoud, Mohamed Naguib Massoud, Maria Amalia Matamoros, Rosa Martín Mateos, Asmaa Mawed, Jean Claude Mbanya, Charles Mbendi, Lone McColaugh, Duncan McLeod, Juan Francisco Rivera Medina, Ahmed Megahed, Mai Mehrez, Iqbal Memon, Shahin Merat, Randy Mercado, Ahmed Mesbah, Taoufik Meskini, Mayada Metwally, Rasha Metwaly, Lei Miao, Eileen Micah, Luca Miele, Vladimir Milivojevic, Tamara Milovanovic, Yvonne L. Mina, Milan Mishkovik, Amal Mishriki, Tim Mitchell, Alshaimaa Mohamed, Mona Mohamed, Sofain Mohamed, Shady Mohammed, Ahmed Mohammed, Viswanathan Mohan, Sara Mohie, Aalaa Mokhtar, Reham Moniem, Mabel Segura Montilla, Jose Antonio Orozco Morales, María María Sánchez Morata, Jose Maria Moreno-Planas, Silvia Morise, Sherif Mosaad, Mohamed Moselhy, Alaa Mohamed Mostafa, Ebraheem Mostafa, Nezha Mouane, Nasser Mousa, Hamdy Mahfouz Moustafa, Abeer Msherif, Kate Muller, Christopher Munoz, Ana Beatriz Muñoz-Urribarri, Omar Alfaro Murillo, Feisul Idzwan Mustapha, Emir Muzurović, Yehia Nabil, Shaymaa Nafady, Ayu Nagamatsu, Atsushi Nakajima, Dan Nakano, Yuemin Nan, Fabio Nascimbeni, Mirella S. Naseef, Nagwa Nashat, Taran Natalia, Francesco Negro, Alexander V. Nersesov, Manuela Neuman, Masolwa Ng'wanasayi, Yan Ni, Amanda Nicoll, Takashi Niizeki, Dafina Nikolova, Wang Ningning, Madunil Niriella, K.A Nogoibaeva, Rozeena Nordien, Catherine O Sullivan, James O'Beirne, Solomon Obekpa, Ponsiano Ocama, Missiani Ochwoto, Michael Promise Ogolodom, Olusegun Ojo, Nana Okrostsvaridze, Claudia P. Oliveira, Raul Contreras Omaña, Omneya M. Omar, Hanaa Omar, Mabroka Omar, Salma Omran, Reham Omran, Marian Muse Osman, Nevin Owise, Theobald Owusu-Ansah, P. Martín Padilla- Machaca, Sirish Palle, Ziyan Pan, Xiao-Yan Pan, Qiuwei Pan, Apostolis Papaefthymiou, Feliciano Chanana Paquissi, Gabriella Par, Arit Parkash, Diana Payawal, Kevork M. 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L, Kaya, E, Kayasseh, M, Keenan, B, Keklikkiran, C, Keml, W, Khalaf, D, Khalefa, R, Khamis, S, Khater, D, Khattab, H, Khavkin, A, Khlynova, O, Khmis, N, Kobyliak, N, Koffas, A, Koike, K, Kok, K, Koller, T, Komas, N, Korochanskaya, N, Koulla, Y, Koya, S, Kraft, C, Kraja, B, Krawczyk, M, Kuchay, M, Kulkarni, A, Kumar, A, Kumar, M, Lakoh, S, Lam, P, Lan, L, Lange, N, Lankarani, K, Lanthier, N, Lapshyna, K, Lashen, S, Laure, K, Lazebnik, L, Lebrec, D, Lee, S, Lee, W, Lee, Y, Leeming, D, Leite, N, Leon, R, Lesmana, C, Li, J, Li, Q, Li, Y, Li, L, Li, M, Liang, H, Lijuan, T, Lim, S, Lim, L, Lin, S, Lin, H, Lin, R, Lithy, R, Liu, Y, Liu, X, Liu, W, Liu, S, Liu, K, Liu, T, Lonardo, A, Lopez, M, Lopez-Benages, E, Lopez-Jaramillo, P, Lu, H, Lu, L, Lu, Y, Lubel, J, Lui, R, Lupasco, I, Luzina, E, Lv, X, Lynch, K, Ma, H, Machado, M, Maduka, N, Madzharova, K, Magdaong, R, Mahadeva, S, Mahfouz, A, Mahmood, N, Mahmoud, E, Mahrous, M, Maiwall, R, Majeed, A, Majumdar, A, Mak, L, Maklouf, M, Malekzadeh, R, Mandato, C, Mangia, A, Mann, J, Mansour, H, Mansouri, A, Mantovani, A, Mao, J, Maramag, F, Marchesini, G, Marcus, C, Marinho, R, Martinez-Chantar, M, Martins, A, Marwan, R, Mason, K, Masoud, G, Massoud, M, Matamoros, M, Mateos, R, Mawed, A, Mbanya, J, Mbendi, C, Mccolaugh, L, Mcleod, D, Medina, J, Megahed, A, Mehrez, M, Memon, I, Merat, S, Mercado, R, Mesbah, A, Meskini, T, Metwally, M, Metwaly, R, Miao, L, Micah, E, Miele, L, Milivojevic, V, Milovanovic, T, Mina, Y, Mishkovik, M, Mishriki, A, Mitchell, T, Mohamed, A, Mohamed, M, Mohamed, S, Mohammed, S, Mohammed, A, Mohan, V, Mohie, S, Mokhtar, A, Moniem, R, Montilla, M, Morales, J, Morata, M, Moreno-Planas, J, Morise, S, Mosaad, S, Moselhy, M, Mostafa, A, Mostafa, E, Mouane, N, Mousa, N, Moustafa, H, Msherif, A, Muller, K, Munoz, C, Munoz-Urribarri, A, Murillo, O, Mustapha, F, Muzurovic, E, Nabil, Y, Nafady, S, Nagamatsu, A, Nakajima, A, Nakano, D, Nan, Y, Nascimbeni, F, Naseef, M, Nashat, N, Natalia, T, Negro, F, Nersesov, A, Neuman, M, Ng'Wanasayi, M, Ni, Y, Nicoll, A, Niizeki, T, Nikolova, D, Ningning, W, Niriella, M, Nogoibaeva, K, Nordien, R, O Sullivan, C, O'Beirne, J, Obekpa, S, Ocama, P, Ochwoto, M, Ogolodom, M, Ojo, O, Okrostsvaridze, N, Oliveira, C, Omana, R, Omar, O, Omar, H, Omar, M, Omran, S, Omran, R, Osman, M, Owise, N, Owusu-Ansah, T, Padilla- Machaca, P, Palle, S, Pan, Z, Pan, X, Pan, Q, Papaefthymiou, A, Paquissi, F, Par, G, Parkash, A, Payawal, D, Peltekian, K, Peng, X, Peng, L, Peng, Y, Pengoria, R, Perez, M, Perez, J, Perez, N, Persico, M, Pessoa, M, Petta, S, Philip, M, Plaz Torres, M, Polavarapu, N, Poniachik, J, Portincasa, P, Pu, C, Purnak, T, Purwanto, E, Qi, X, Qian, Z, Qiang, Z, Qiao, Z, Qiao, L, Queiroz, A, Rabiee, A, Radwan, M, Rahetilahy, A, Ramadan, Y, Ramadan, D, Ramli, A, Ramm, G, Ran, A, Rankovic, I, Rao, H, Raouf, S, Ray, S, Reau, N, Refaat, A, Reiberger, T, Remes-Troche, J, Reyes, E, Richardson, B, Ridruejo, E, Riestra Jimenez, S, Rizk, I, Roberts, S, Roblero, J, Robles, J, Rockey, D, Rodriguez, M, Rodriguez Hernandez, H, Roman, E, Romeiro, F, Romeo, S, Rosales-Zabal, J, Roshdi, G, Rosso, N, Ruf, A, Ruiz, P, Runes, N, Ruzzenente, A, Ryan, M, Saad, A, Sabbagh, E, Sabbah, M, Saber, S, Sabrey, R, Sabry, R, Saeed, M, Said, D, Said, E, Sakr, M, Salah, Y, Salama, R, Salama, A, Saleh, H, Saleh, A, Salem, A, Salifou, A, Salih, A, Salman, A, Samouda, H, Sanai, F, Sanchez-Avila, J, Sanker, L, Sano, T, Sanz, M, Saparbu, T, Sawhney, R, Sayed, F, Sayed, S, Sayed, A, Sayed, M, Sebastiani, G, Secadas, L, Sediqi, K, Seif, S, Semida, N, Senates, E, Serban, E, Serfaty, L, Seto, W, Sghaier, I, Sha, M, Shabaan, H, Shalaby, L, Shaltout, I, Sharara, A, Sharma, V, Shawa, I, Shawkat, A, Shawky, N, Shehata, O, Sheils, S, Shewaye, A, Shi, G, Shi, J, Shimose, S, Shirono, T, Shou, L, Shrestha, A, Shui, G, Sievert, W, Sigurdardottir, S, Sira, M, Siradj, R, Sison, C, Smyth, L, Soliman, R, Sollano, J, Sombie, R, Sonderup, M, Sood, S, Soriano, G, Stedman, C, Stefanyuk, O, Stimac, D, Strasser, S, Strnad, P, Stuart, K, Su, W, Su, M, Sumida, Y, Sumie, S, Sun, D, Sun, J, Suzuki, H, Svegliati-Baroni, G, Swar, M, Taharboucht, S, Taher, Z, Takamura, S, Tan, L, Tan, S, Tanwandee, T, Tarek, S, Tatiana, G, Tavaglione, F, Tecson, G, Tee, H, Teschke, R, Tharwat, M, Thong, V, Thursz, M, Tine, T, Tiribelli, C, Tolmane, I, Tong, J, Tongo, M, Torkie, M, Torre, A, Torres, E, Trajkovska, M, Treeprasertsuk, S, Tsutsumi, T, Tu, T, Tur, J, Turan, D, Turcan, S, Turkina, S, Tutar, E, Tzeuton, C, Ugiagbe, R, Uygun, A, Vacca, M, Vajro, P, Van der Poorten, D, Van Kleef, L, Vashakidze, E, Velazquez, C, Velazquez, M, Vento, S, Verhoeven, V, Vespasiani-Gentilucci, U, Vethakkan, S, Vilaseca, J, Vitek, L, Volkanovska, A, Wallace, M, Wan, W, Wang, Y, Wang, X, Wang, C, Wang, M, Wangchuk, P, Weltman, M, White, M, Wiegand, J, Wifi, M, Wigg, A, Wilhelmi, M, William, R, Wittenburg, H, Wu, S, Wubeneh, A, Xia, H, Xiao, J, Xiao, X, Xiaofeng, W, Xiong, W, Xu, L, Xu, J, Xu, W, Xu, K, Xu, Y, Xu, S, Xu, M, Xu, A, Xu, C, Yan, H, Yang, J, Yang, R, Yang, Y, Yang, Q, Yang, N, Yao, J, Yara, J, Yaras, S, Yilmaz, N, Younes, R, Younes, H, Young, S, Youssef, F, Yu, Y, Yu, M, Yuan, J, Yue, Z, Yuen, M, Yun, W, Yurukova, N, Zakaria, S, Zaky, S, Zaldastanishvili, M, Zapata, R, Zare, N, Zerem, E, Zeriban, N, Zeshuai, X, Zhang, H, Zhang, X, Zhang, Y, Zhang, W, Zhang, Z, Zhao, J, Zhao, R, Zhao, H, Zheng, C, Zheng, Y, Zheng, R, Zheng, T, Zheng, K, Zhou, X, Zhou, Y, Zhou, H, Zhou, L, Zhu, L, Zhu, Y, Zhu, P, Ziada, E, Ziring, D, Ziyi, L, Zou, S, Zou, Z, Zou, H, Zuart Ruiz, R, and Global Multi-Stakeholder Consensus on the Redefinition of Fatty Liver Disease

Subjects
Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Hepatology, Non-alcoholic Fatty Liver Disease, NAFLD, consensu, Gastroenterology, MAFLD, definition, Humans, MAFLD, NAFLD, Human medicine
Abstract

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2022
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38. LA ADMINISTRACIÓN DE LA TERAPIA CUÁDRUPLE CON BISMUTO EN CÁPSULA ÚNICA TRES VECES AL DÍA AUMENTA LA EFICACIA EN COMPARACIÓN CON LA PAUTA CONVENCIONAL DE CUATRO DOSIS DIARIAS: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Ángeles Pérez-Aísa, Olga P. Nyssen, Alma Keco-Huerga, Luis Rodrigo, Alfredo J Lucendo, Blas José Gómez Rodríguez, Juan Ortuño, Mónica Perona, José M. Huguet, Óscar Núñez, Luis Fernández-Salazar, Jesús Barrio, Ángel Lanas, Eduardo Iyo, Pilar Mata Romero, Miguel Fernández- Bermejo, Barbara Gomez, Ana Garre, Judith Gomez-Camarero, Luis Javier Lamuela, Ana Campillo, Luisa C de la Peña-Negro, Manuel Dominguez-Cajal, Luis Bujanda, Diego Burgos-Santamaria, Fernando Bermejo, Víctor González-Carrera, Ramón Pajares, Pedro Almela Notari, Javier Tejedor-Tejada, Montserrat Planella, Itxaso Jiménez, Yolanda Arguedas Lázaro, Antonio Cuadrado-Lavín, Isabel Pérez-Martínez, Edurne Amorena, Jesús M González- Santiago, Teresa Angueira, Virginia Flores, Samuel Jesús Martínez-Domínguez, Manuel Pabón-Carrasco, Benito Velayos, Alicia Algaba, Consuelo Ramírez, Enrique Alfaro Almajano, Manuel Castro-Fernández, Noelia Alcaide, Patricia Sanz Segura, Anna Cano-Català, Natalia García- Morales, Leticia Moreira, Francis Mégraud, Colm O’Morain, Xavier Calvet, and Javier P. Gisbert

Subjects
Hepatology, Gastroenterology
Published
2023
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40. Using matrix norms to estimate the direction of arrival of planar waves on an ULA

Author

Hugo Silva, Yroá R. Ferreira, Diego Burgos, Oliver Sander, Edna Lúcia Flôres, Jonas Kunzler, Mário José de Souza, and Rodrigo Pinto Lemos

Subjects
Computer Networks and Communications, Applied Mathematics, Plane wave, Matrix norm, Estimator, Direction of arrival, 020206 networking & telecommunications, 02 engineering and technology, Reduction (complexity), Singular value, Planar, Control and Systems Engineering, Singular value decomposition, Signal Processing, 0202 electrical engineering, electronic engineering, information engineering, Applied mathematics, 020201 artificial intelligence & image processing, Mathematics
Abstract

SEAD method estimates the direction-of-arrival angles on an uniformly linear array based on the difference between the two largest singular values, what is called differential spectrum. Although it presented an outstanding performance, the ability to indicate the source positions was not elucidated yet. Inspired by the differential spectrum formulation we derived a total differential spectrum and found out that the matrix norm induced by the vector 2-norm of a modified spatial covariance matrix can be used to estimate the direction-of-arrival of multiple plane waves. Indeed we show that matrix norms are estimators and we propose their use instead of the singular value decomposition in SEAD-based methods. We present a general mathematical expression in order to explicit the operating principles of the proposed methods. Consequently, we were able to explain how the relation between the arriving and the search angles produces the larger peaks on the differential spectrum. To evaluate the important role played by matrix norms, a thousand experiments were carried out. They showed that the proposed approach proved to be as accurate as the previous SEAD-based methods, while providing a significant reduction on runtime. It also outperformed well-established methods like MODEX regarding the estimation error.

Published
2019
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41. Decompensation in Advanced Nonalcoholic Fatty Liver Disease May Occur at Lower Hepatic Venous Pressure Gradient Levels Than in Patients With Viral Disease

Author

Alexia Laroyenne, Laura Turco, Sven Francque, Lucile Moga, Johannes Chang, Jonel Trebicka, Sabela Lens, Thomas Reiberger, Wilhelmus J. Kwanten, Luis Téllez, Bogdan Procopet, Diego Burgos-Santamaría, Rafael Bañares, Georg Semmler, Giulia Tosetti, Rafael Paternostro, Filippo Schepis, Élise Vuille-Lessard, Helena Masnou, Pol Olivas, Miquel Serra-Burriel, Thomas Vanwolleghem, Pere Ginès, Càndid Villanueva, Isabel Graupera, Annalisa Cippitelli, Annalisa Berzigotti, Angela Puente, Wim Laleman, Virginia Hernández-Gea, Luis Ibañez, J.C. Garcia-Pagan, Elba Llop, Mattias Mandorfer, Edilmar Alvarado, Pierre-Emmanuel Rautou, Horia Stefanescu, Oana Farcau, Hélène Larrue, Xavier Forns, Octavi Bassegoda, Cristophe Bureau, Jose Ignacio Fortea, Salvador Augustin, Agustín Albillos, Francesca Miceli, Massimo Primignani, and Alexander Zipprich

Subjects
Liver Cirrhosis, medicine.medical_specialty, Cirrhosis, Portal venous pressure, Cirrhosis Decompensation, HVPG, NAFLD, NASH, Portal Hypertension, 610 Medicine & health, Severity of Illness Index, Gastroenterology, End Stage Liver Disease, Liver disease, Non-alcoholic Fatty Liver Disease, Internal medicine, Hypertension, Portal, Nonalcoholic fatty liver disease, medicine, Humans, Decompensation, Hepatology, business.industry, Hepatitis C, medicine.disease, Portal Pressure, Cross-Sectional Studies, RNA, Portal hypertension, Human medicine, Liver function, business
Abstract

BACKGROUND & AIMS: Portal hypertension is the strongest predictor of hepatic decompensation and death in patients with cirrhosis. However, its discriminatory accuracy in patients with nonalcoholic fatty liver disease (NAFLD) has been challenged because hepatic vein catheterization may not reflect the real portal vein pressure as accurately as in patients with other etiologies. We aimed to evaluate the relationship between hepatic venous pressure gradient (HVPG) and presence of portal hypertension-related decompensation in patients with advanced NAFLD (aNAFLD). METHODS: Multicenter cross-sectional study included 548 patients with aNAFLD and 444 with advanced RNA-positive hepatitis C (aHCV) who had detailed portal hypertension evaluation (HVPG measurement, gastroscopy, and abdominal imaging). We examined the relationship between etiology, HVPG, and decompensation by logistic regression models. We also compared the proportions of compensated/decompensated patients at different HVPG levels. RESULTS: Both cohorts, aNAFLD and aHVC, had similar baseline age, gender, Child-Pugh score, and Model for End-Stage Liver Disease score. Median HVPG was lower in the aNAFLD cohort (13 vs 15 mmHg) despite similar liver function and higher rates of decompensation in aNAFLD group (32% vs 25%; P = .019) than in the aHCV group. For any of the HVPG cutoff analyzed (

Published
2022
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46. Endoscopy-Related Bleeding and Thromboembolic Events in Patients on Direct Oral Anticoagulants or Vitamin K Antagonists

Author

Sofía Parejo-Carbonell, Ángel F. Marcos Martín, Ana Gómez-Outomuro, María López-Cerón, Giulia Pagano, Alfonso Muriel, Carmen María González González, Miguel Fraile-López, Marta Rodríguez-Carrasco, Beatriz Peñas-García, Marta Roldán-Fernández, Alba Martínez-Sánchez, Teresa Álvarez-Nava Torrego, Enrique Vazquez-Sequeiros, Charly Guarner-Argente, Gloria Fernández-Esparrach, David Rafael de la Cruz Esteban, Alberto Herreros-de-Tejada, Carlos Ferre Aracil, Miguel Ángel de Jorge-Turrión, Matilde Núñez Esteban, María Luisa Arias-Rivera, Elsa de la Fuente-Briongos, Diego de Frutos, María Isabel Altamirano, Sergio López-Duran, Diego Burgos-Santamaría, Eva Barreiro-Alonso, Gemma Casals Urquiza, Raquel Ríos León, Agustín Albillos, Ángel Cañete-Ruiz, Francisco Mesonero-Gismero, Luis Téllez, Beatriz Mateos Muñoz, Eduardo Tavío-Hernádez, Ana García Cid, Enrique Rodríguez de Santiago, Héctor Miguel Marcos-Prieto, Pedro Delgado-Guillena, Pablo Pérez Riveras, Javier Zamora, Mireia Ruiz-Andreu, Ana García-Rodríguez, Juan Ángel González-Martín, Ana García García de Paredes, Carlos Rodríguez Escaja, Rubén Sánchez Aldehuelo, Jose Ramon Foruny-Olcina, Fausto Riu Pons, Aida Argüelles Longoria, Miguel Urpi Ferreruela, Julia Arribas-Anta, Daniel Pérez-Corte, Marta Aicart-Ramos, and Carla Senosiaín-Lalastra

Subjects
medicine.medical_specialty, Gastrointestinal bleeding, Vitamin K, medicine.drug_class, Administration, Oral, Colonic Polyps, Article, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Internal medicine, medicine, Humans, Prospective Studies, Prospective cohort study, Endoscopic retrograde cholangiopancreatography, Hepatology, medicine.diagnostic_test, business.industry, Anticoagulant, Gastroenterology, Anticoagulants, Odds ratio, Colonoscopy, Vitamin K antagonist, medicine.disease, Endoscopy, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, business, Gastrointestinal Hemorrhage
Abstract

Few prospective studies have assessed the safety of direct oral anticoagulants (DOACs) in elective endoscopy. Our primary aim was to compare the risks of endoscopy-related gastrointestinal bleeding and thromboembolic events in patients on DOACs or vitamin K antagonists (VKAs) in this setting. Secondarily, we examined the impact of the timing of anticoagulant resumption on the risk of delayed bleeding in high-risk therapeutic procedures.We conducted a multicenter, prospective, observational study from January 2018 to March 2020 of 1602 patients on oral anticoagulants (1004 on VKAs and 598 on DOACs) undergoing 1874 elective endoscopic procedures. Our primary outcomes were 90-day thromboembolic events and 30-day endoscopy-related gastrointestinal bleeding. The inverse probability of treatment weighting propensity score method was used for baseline covariate adjustment.The 2 groups had similar risks of endoscopy-related gastrointestinal bleeding (VKAs vs DOACs, 6.2% vs 6.7%; adjusted odds ratio [OR], 1.05; 95% CI, 0.67-1.65) and thromboembolic events (VKAs vs DOACs, 1.3% vs 1.5%; adjusted OR, 0.90; 95% CI, 0.34-2.38). In high bleeding risk procedures (n = 747), delayed anticoagulant resumption (48 hours or 24-48 hours vs24 hours) did not reduce the risk of postprocedural bleeding (10.3%, 9%, and 5.8%, respectively; adjusted P = .43). Hot and cold snare polypectomy were the most frequent high-risk interventions (41.8% and 39.8%, respectively).In a prospective study of patients on DOACs or VKAs undergoing elective endoscopy, endoscopy-related bleeding and thromboembolic events showed similar risk. Our study suggests that early anticoagulant resumption is safe in most patients, but more data are needed for advanced high-risk therapeutic procedures.

Published
2020

47. BigDataStack - D3.1 WP 3 Scientific Report and Prototype Description - Y1

Author

Orlando Avila-García, Ismael Cuadrado-Cordero, Bernat Quesada, Marti Sanchez, Matteo Sotil, Jean Didier Totow, Sophia Karagiorgou, Nikos Drosos, Mauricio Fadel Argerich, Bin Cheng, Pavlos Kranas, Ricardo Jiménez-Peris, Jose Maria Zaragoza, Diego Burgos Sancho, Javier López Moratalla, Richard McCreadie, Marta Patiño, Ainhoa Azqueta, and Luis Tomas Bolivar

Abstract

This deliverable presents Scientific Report and Prototype Description for the work carried out in the first year of the BigDataStack project, related to the so-called Data-Driven Infrastructure Management capability of the BigDataStack platform. The document shows how the implementation of the solution is planned to be delivered following an incremental and iterative methodology, having cycles of implementation and experimentation. The document describes: the high-level assumptions and architecture of the capability, as well as detailed requirements, design and prototypes per component; the experimental use case scenarios and plans, as well as the experimental plan per component and its mapping with the use case scenarios., {"references":["Network Policies in Kubernetes. Available Online: https://kubernetes.io/docs/concepts/services-networking/network-policies/","Project Calico. Available Online: https://www.projectcalico.org/","Istio. Available Online: https://istio.io/","de Vaulx, Frederic J., Eric D. Simmon, and Robert B. Bohn (2018). \"Cloud computing service metrics description.\" Special Publication (NIST SP)-500-307. 2018.","William Voorsluys, James Broberg, Srikumar Venugopal, Rajkumar Buyya, Martin Gilje Jaatun, Gansen Zhao, Chunming Rong (2009). \"Cost of Virtual Machine Live Migration in Clouds: A Performance Evaluation\", Cloud Computing, Springer Berlin Heidelberg, 2009, P 254-265","D. Guyon, A. Orgerie, C. Morin and D. Agarwal (2017). \"How Much Energy Can Green HPC Cloud Users Save?\" in 25th Euromicro International Conference on Parallel, Distributed and Network-based Processing (PDP), St. Petersburg, 2017, pp. 416-420.","Gulisano, V., Jimenez-Peris, R., Patino-Martinez, M., Soriente, C., & Valduriez, P. (2012). \"Streamcloud: An elastic and scalable data streaming system.\" IEEE Transactions on Parallel and Distributed Systems, pp. 2351-2365.","H. Rui et al. (2014). \"Enabling cost-aware and adaptive elasticity of multi-tier cloud applications.\" Future Generation Computer Systems, pp. 82-98.","Kalervo and Jaana. (2002). \"Cumulated gain-based evaluation of IR techniques.\" ACM Transactions on Information Systems (TOIS), pp. 422--446.","L. Tie-Yan. (2009). \"Learning to rank for information retrieval.\" Foundations and Trends in Information Retrieval, pp. 225-331.","M. Ferdman et al. (2012). \"Clearing the clouds: a study of emerging scale-out workloads on modern hardware.\" ACM SIGPLAN Notices, pp. 37-48. ACM.","Raschke, R. (2010). \"Process-based view of agility: The value contribution of IT and the effects on process outcomes.\" International Journal of Accounting Information Systems, 11(4), pp. 297-313.","Salton and McGill. (1986). \"Introduction to modern information retrieval.\" McGraw-Hill, Inc.","Sergey and Christian. (2015). \"Batch normalization: Accelerating deep network training by reducing internal covariate shift.\" arXiv preprint.","Z. Jia et al. (2013). \"Characterizing data analysis workloads in data centers.\" IEEE International Symposium on Workload Characterization (IISWC), pp. 66-76. IEEE."]}

Published
2020
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48. Bismuth quadruple regimen with tetracycline or doxycycline versus three‐in‐one single capsule as third‐line rescue therapy for Helicobacter pylori infection: Spanish data of the European Helicobacter pylori Registry (Hp‐EuReg)

Author

Manuel J. Castro, Jesus Barrio, Tommaso Di Maira, Javier P. Gisbert, Pilar Varela, Francis Mégraud, Judith Gomez-Camarero, Noelia Alcaide, Ariadna Figuerola, Manuel Domínguez-Cajal, Liliana Pozzati, Luis Fernández-Salazar, Nuria Fernández, Colm O'Morain, Pilar Mata Romero, Jenifer Hinojosa, Luis Bujanda, Llúcia Titó, Luis Ferrer, Javier Molina-Infante, Luis Rodrigo, Diego Burgos, Ángeles Pérez-Aisa, Elena Resina, Ignasi Puig, José María Huguet, Cristobal De la Coba, Juan Ortuño, Barbara Gomez, Monica Perona, Olga P Nyssen, Ana Garre, Ines Modollel, Alfredo J. Lucendo, Maria Caldas, Xavier Calvet, Blas Jose Gómez Rodríguez, and Manuel Jimenez-Moreno

Subjects
Doxycycline, medicine.medical_specialty, biology, Tetracycline, business.industry, Gastroenterology, Capsule, General Medicine, Helicobacter pylori, biology.organism_classification, 03 medical and health sciences, Regimen, Metronidazole, 0302 clinical medicine, Infectious Diseases, Levofloxacin, 030220 oncology & carcinogenesis, Internal medicine, Clarithromycin, medicine, 030211 gastroenterology & hepatology, business, medicine.drug
Abstract

Background Different bismuth quadruple therapies containing proton-pump inhibitors, bismuth salts, metronidazole, and a tetracycline have been recommended as third-line Helicobacter pylori eradication treatment after failure with clarithromycin and levofloxacin. Aim To evaluate the efficacy and safety of third-line treatments with bismuth, metronidazole, and either tetracycline or doxycycline. Methods Sub-study with Spanish data of the "European Registry on H pylori Management" (Hp-EuReg), international multicenter prospective non-interventional Registry of the routine clinical practice of gastroenterologists. After previous failure with clarithromycin- and levofloxacin-containing therapies, patients receiving a third-line regimen with 10/14-day bismuth salts, metronidazole, and either tetracycline (BQT-Tet) or doxycycline (BQT-Dox), or single capsule (BQT-three-in-one) were included. Data were registered at AEG-REDCap database. Univariate and multivariate analyses were performed. Results Four-hundred and fifty-four patients have been treated so far: 85 with BQT-Tet, 94 with BQT-Dox, and 275 with BQT-three-in-one. Average age was 53 years, 68% were women. Overall modified intention-to-treat and per-protocol eradication rates were 81% (BQT-Dox: 65%, BQT-Tet: 76%, BQT-three-in-one: 88%) and 82% (BQT-Dox: 66%, BQT-Tet: 77%, BQT-three-in-one: 88%), respectively. By logistic regression, higher eradication rates were associated with compliance (OR = 2.96; 95% CI = 1.01-8.84) and no prior metronidazole use (OR = 1.96; 95% CI = 1.15-3.33); BQT-three-in-one was superior to BQT-Dox (OR = 4.46; 95% CI = 2.51-8.27), and BQT-Tet was marginally superior to BQT-Dox (OR = 1.67; 95% CI = 0.85-3.29). Conclusion Third-line H pylori eradication with bismuth quadruple treatment (after failure with clarithromycin and levofloxacin) offers acceptable efficacy and safety. Highest efficacy was found in compliant patients and those taking 10-day BQT-three-in-one or 14-day BQT-Tet. Doxycycline seems to be less effective and therefore should not be recommended.

Published
2020
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49. Bismuth quadruple regimen with tetracycline or doxycycline versus three-in-one single capsule as third-line rescue therapy for Helicobacter pylori infection: Spanish data of the European Helicobacter pylori Registry (Hp-EuReg)

Author

Olga P, Nyssen, Angeles, Perez-Aisa, Luis, Rodrigo, Manuel, Castro, Pilar, Mata Romero, Juan, Ortuño, Jesus, Barrio, Jose Maria, Huguet, Ines, Modollel, Noelia, Alcaide, Alfredo, Lucendo, Xavier, Calvet, Monica, Perona, Barbara, Gomez, Blas Jose, Gomez Rodriguez, Pilar, Varela, Manuel, Jimenez-Moreno, Manuel, Dominguez-Cajal, Liliana, Pozzati, Diego, Burgos, Luis, Bujanda, Jenifer, Hinojosa, Javier, Molina-Infante, Tommaso, Di Maira, Luis, Ferrer, Luis, Fernández-Salazar, Ariadna, Figuerola, Llucia, Tito, Cristobal, de la Coba, Judith, Gomez-Camarero, Nuria, Fernandez, Maria, Caldas, Ana, Garre, Elena, Resina, Ignasi, Puig, Colm, O'Morain, Francis, Megraud, and Javier P, Gisbert

Subjects
Adult, Aged, 80 and over, Male, Adolescent, Helicobacter pylori, Proton Pump Inhibitors, Middle Aged, Tetracycline, Anti-Bacterial Agents, Helicobacter Infections, Drug Combinations, Young Adult, Treatment Outcome, Spain, Doxycycline, Metronidazole, Humans, Drug Therapy, Combination, Female, Prospective Studies, Bismuth, Aged
Abstract

Different bismuth quadruple therapies containing proton-pump inhibitors, bismuth salts, metronidazole, and a tetracycline have been recommended as third-line Helicobacter pylori eradication treatment after failure with clarithromycin and levofloxacin.To evaluate the efficacy and safety of third-line treatments with bismuth, metronidazole, and either tetracycline or doxycycline.Sub-study with Spanish data of the "European Registry on H pylori Management" (Hp-EuReg), international multicenter prospective non-interventional Registry of the routine clinical practice of gastroenterologists. After previous failure with clarithromycin- and levofloxacin-containing therapies, patients receiving a third-line regimen with 10/14-day bismuth salts, metronidazole, and either tetracycline (BQT-Tet) or doxycycline (BQT-Dox), or single capsule (BQT-three-in-one) were included. Data were registered at AEG-REDCap database. Univariate and multivariate analyses were performed.Four-hundred and fifty-four patients have been treated so far: 85 with BQT-Tet, 94 with BQT-Dox, and 275 with BQT-three-in-one. Average age was 53 years, 68% were women. Overall modified intention-to-treat and per-protocol eradication rates were 81% (BQT-Dox: 65%, BQT-Tet: 76%, BQT-three-in-one: 88%) and 82% (BQT-Dox: 66%, BQT-Tet: 77%, BQT-three-in-one: 88%), respectively. By logistic regression, higher eradication rates were associated with compliance (OR = 2.96; 95% CI = 1.01-8.84) and no prior metronidazole use (OR = 1.96; 95% CI = 1.15-3.33); BQT-three-in-one was superior to BQT-Dox (OR = 4.46; 95% CI = 2.51-8.27), and BQT-Tet was marginally superior to BQT-Dox (OR = 1.67; 95% CI = 0.85-3.29).Third-line H pylori eradication with bismuth quadruple treatment (after failure with clarithromycin and levofloxacin) offers acceptable efficacy and safety. Highest efficacy was found in compliant patients and those taking 10-day BQT-three-in-one or 14-day BQT-Tet. Doxycycline seems to be less effective and therefore should not be recommended.

Published
2020

50. Why is the rate of pneumococcal pneumonia declining?

Author

Diego Burgos, Carlos M. Luna, and Laura Pulido

Subjects
Immunity, Herd, Pulmonary and Respiratory Medicine, Vaccines, Conjugate, business.industry, Pneumonia, Pneumococcal, medicine.disease, Polysaccharide Vaccine, medicine.disease_cause, Antimicrobial, Anti-Bacterial Agents, Herd immunity, Pneumococcal Vaccines, 03 medical and health sciences, Pneumonia, 0302 clinical medicine, 030228 respiratory system, Immunity, Streptococcus pneumoniae, Immunology, Pneumococcal pneumonia, Etiology, Humans, Medicine, 030212 general & internal medicine, business
Abstract

Purpose of review As Streptococcus pneumoniae was considered the etiological agent of nearly all the cases of pneumonia at the beginning of the 20th century, and today is identified in fewer than 10-15% of cases, we analyze the possible causes of such a decline. Recent findings Extensive use of early empiric antimicrobial therapy, discovery of previously unrecognized pathogens, availability to newer diagnostic methods for the recognition of the pneumonia pathogens (PCR, urinary antigens, monoclonal antibodies etc.) and of improved preventive measures, including vaccines, are some of possible explanations of the declining role of S. pneumoniae in the cause of pneumonia. Summary The 14-valent and the 23-valent capsular polysaccharide pneumococcal vaccines were licensed in 1977 and 1983, respectively. The seven-valent protein-conjugated capsular polysaccharide vaccine, approved for routine use in children starting at 2 months of age, was highly effective in preventing invasive pneumococcal disease in children but also in adults because of the herd effect. In 2010, the 13-valent protein-conjugated capsular polysaccharide vaccine replaced seven-valent protein-conjugated capsular polysaccharide vaccine. With the use of conjugated vaccines, a decrease of the vaccine-type invasive pneumococcal disease for all age groups was observed. Both the direct effect of the vaccine and the so-called herd immunity are considered responsible for much of the decline.

Published
2018
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