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AIM To verify the applicability of a new theory for chemomic release kinetics of traditional Chinese medicines using the release characteristics of Yinqiaojiedu tablets. METHODS The methodological studies of the preparation of chemomic standard spectrum, linearity, precision and stability tests of the chemomes of Yinqiaojiedu tablets were processed by UV spectrophotometry and Kalman filter methods. The chemomic release profiles of Yinqiaojiedu tablets and powders were determined. RESULT The methodology studies indicated that there was a good linearity of chemomic concentration of Yinqiaojiedu tablets within the range 0.112 to 1.120 mg total herbs / mL ( r = 0.999 7). The values of RSD tested at three chemomic levels were 0.05 %, 0.07 % and 0.31 % respectively. The chemomic solutions were stable for 24 h at concentrations of 0.278, 0.556, and 1.120 mg total herb / mL. CONCLUSION The chemomic release profiles demonstrated multi-component release kinetics illustrated using a simple visualization approach. The new theory of chemomic release kinetics may advantageously provide a quantitative description for the release of the active agents from traditional Chinese medicines from a conventional dosage form or drug delivery system.

Yinqiaojiedu honeyed pills were equally divided into 1/4, 1/8, 1/12, and 1/16 parts. The materiomics release rates within 12 h of the intact Yinqiaojiedu honeyed pills and the divided granules were determined by the paddle method with a rotate speed at 100 r x min(-1), and the materiome was quantified by UV-scan and Kalman filter methods. The intact Yinqiaojiedu honeyed pills behaved typical sustained release profiles, while the well-divided portions also maintained a sustained release profile over 2-4 h. The release rates were well correlated with the extents for the divisions of the pills. The Weibull distribution parameters, Td and T50, were reduced in line with the particle size, indicating that the ways of administration of the pills may play a role in the in vivo pharmacokinetics of the pills. The visualization results showed obvious difference of materiomic release synchronicities between the intact pills and the equally divided particles, and the divisions enhanced the asynchronization. Therefore the novel theory of materiomic release/dissolution kinetics of traditional Chinese medicines (TCMs) quantitatively proved the traditional dosage form, namely, honeyed pills, as a prototype of the sustained-release dosage form with a visualization of the scientific connotation to the old saying in the classics of TCM, Pills, the moderate ones in action. In terms of materiome increase for each period of the release profiles, the materiomic release synchronicity was visually demonstrated. The novel theories provided methodological basis for the evaluation of traditional dosage forms and the design of the modern drug delivery systems for TCMs.