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Introduction: The multidisciplinary approach in healthcare unites professionals from different fields to deliver patient-centered care. This collaborative team, comprising care partners, hospitalists, nurses, pharmacists, and others, operates with shared goals, leveraging electronic records, regular assessments, and patient involvement. Objective: In this review, we aim to investigate the challenges and benefits of a multidisciplinary approach to treatment in clinical medicine. Methodology: In our study, we included English studies from online databases such asWeb of Science, Scopus, Google Scholar, PubMed, and the Cochrane Library using the following keywords “delusions”, “pharmacotherapy”, “psychotherapy”, and “antipsychotics” till January 2024. Results: The result of the search using our search strategy was 2367 articles. We screened these articles to choose the articles related to our topic. We did a full-text screening of 344 articles after excluding the remaining articles by title and abstract screening. Finally, we used 50 articles to gather information about our topic and write this review. Scientific Novelty: Lies in its integration of diverse expertise, methodologies, and perspectives to address complex healthcare challenges. Practical Significance of the Results Obtained: Its practical significance lies in improving patient outcomes, optimizing resource utilization, and fostering innovation through collaborative problem-solving and evidence-based practices. Conclusion: This literature review focused on the multidisciplinary approach in medicine to ensure quality healthcare for patients. Stressing the advantages such as decreasing negative patient outcomes and increasing treatment strategies by collaboration among health care professionals. [ABSTRACT FROM AUTHOR]