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2. SARS-CoV-2 Infection and Risk Management in Multiple Sclerosis

Author

Amado Diaz de la Fe, Alejandro Armando Peláez Suárez, Marinet Fuentes Campos, Maivis Noemí Cabrera Hernández, Carlos-Alberto Goncalves, Stephen Schultz, Dario Siniscalco, and Maria Angeles Robinson-Agramonte

Subjects
SARS-CoV-2, COVID-19, multiple sclerosis (MS), benefit versus risk in multiple sclerosis (BRMS), Medicine
Abstract

The novel coronavirus can cause a severe respiratory disease with impact on the central nervous system, as has been reported by several medical health services. In the COVID-19 pandemic caused by the SARS-CoV-2 neurotrophic virus, neurologists have focused their attention on the early identification of suggestive manifestations of the neurological impact of the disease. In this context, they are exploring related chronic disease and the possibility of achieving a more effective understanding of symptoms derived from COVID-19 infection and those derived from the course of preexisting neurological disease. The present review summarizes evidence from the infection with SARS-CoV-2 and the management of the risks of multiple sclerosis and how it is related to the risks of general comorbidities associated with COVID-19. In addition, we reviewed other factors characteristic of MS, such as relapses, and the maximum tolerated dose of treatment medications from clinical and experimental evidence.

Published
2021
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3. Status of the neuromyelitis optica spectrum disorder in Latin America

Author

Priscilla Monterrey, Fernando Hamuy, Vladimiro Sinay, Lorna Galleguillos, Luis Cesar Rodriguez, Aron Benzadón, Ricardo Alonso, Luis Alberto Garcia, Ramiro Fernández Calderón, Marianne Kagi Guzman, Dario Tavolini, Juan Carlos Duran Quiroz, Jairo Quiñones, Jorge Martínez, Nicia Eunice Ramirez, Victor M. Rivera, Denis Bernardi Bichuetti, Andres Villa, Awilda Candelario, Ernesto Arturo Cornejo, Eli Skromne, Edgar Carnero Contentti, Ligia lbeth Portillo, Veronica Rivas, Amado Diaz de la Fe, Cynthia Veronica Fleitas, Andrés Barboza, Irene Trevino Frenk, Fernando Gracia, Carlos Oviedo Cedeño, Ericka Lopez, César Caparó-Zamalloa, Alejandro R. Diaz, Luis Zarco, Carlos Bolaña, Brenda Bertado, Ibis Soto, Marco Aurélio Lana-Peixoto, Ethel Ciampi, Omaira Molina, Alfredo Perez Canabal, Alexander Parajeles, Elizabeth Armas, Biany Santos Pujol, Patricio Abad-Herrera, Juan Ignacio Rojas, Jose Vera Raggio, A. Soto, Douglas Kazutoshi Sato, Laura Ordonez, Jefferson Becker, Emmanuel Rodríguez, Deyanira A. Ramirez, Vanessa Sirias, Marianella Hernández, Vanessa Daccah Marques, Edgard Rojas, Adriana Carrá, Gil Playas, Roberto Weiser, Oscar Gonzalez Gamarra, Johana Vásquez Céspedes, Jorge Correale, and Edgar Patricio Correa-Díaz

Subjects
medicine.medical_specialty, Population, Ethnic group, Disease, Transverse myelitis, Serology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Optic neuritis, 030212 general & internal medicine, education, Autoantibodies, Aquaporin 4, education.field_of_study, Neuromyelitis optica, business.industry, Neuromyelitis Optica, General Medicine, medicine.disease, Latin America, Neurology, Cohort, Myelin-Oligodendrocyte Glycoprotein, Neurology (clinical), Neoplasm Recurrence, Local, business, 030217 neurology & neurosurgery
Abstract

BACKGROUND Neuromyelitis optica spectrum disorders (NMOSD) is an increasing diagnostic and therapeutic challenge in Latin America (LATAM). Despite the heterogeneity of this population, ethnic and socioeconomic commonalities exist, and epidemiologic studies from the region have had a limited geographic and population outreach. Identification of some aspects from the entire region are lacking. OBJECTIVES To determine ethnic, clinical characteristics, and utilization of diagnostic tools and types of therapy for patients with NMOSD in the entire Latin American region. METHODS The Latin American Committee for Treatment and Research in MS (LACTRIMS) created an exploratory investigational survey addressed by Invitation to NMOSD Latin American experts identified through diverse sources. Data input closed after 30 days from the initial invitation. The questionnaire allowed use of absolute numbers or percentages. Multiple option responses covering 25 themes included definition of type of practice; number of NMOSD cases; ethnicity; utilization of the 2015 International Panel criteria for the diagnosis of Neuromyelitis optica (IPDN); clinical phenotypes; methodology utilized for determination of anti-Aquaporin-4 (anti- AQP4) antibodies serological testing, and if this was performed locally or processed abroad; treatment of relapses, and long-term management were surveyed. RESULTS We identified 62 investigators from 21 countries reporting information from 2154 patients (utilizing the IPDN criteria in 93.9% of cases), which were categorized in two geographical regions: North-Central, including the Caribbean (NCC), and South America (SA). Ethnic identification disclosed Mestizos 61.4% as the main group. The most common presenting symptoms were concomitant presence of optic neuritis and transverse myelitis in 31.8% (p=0.95); only optic neuritis in 31.4% (more common in SA), p

Published
2021

4. Status of the neuromyelitis optica spectrum disorder in Latin America

Author

Rivera, Victor M., primary, Hamuy, Fernando, additional, Rivas, Veronica, additional, Gracia, Fernando, additional, Rojas, Juan Ignacio, additional, Bichuetti, Denis Bernardi, additional, Villa, Andres Maria, additional, Marques, Vanessa Daccah, additional, Soto, Arnoldo, additional, Bertado, Brenda, additional, Frenk, Irene Trevino, additional, Galleguillos, Lorna, additional, Quiñones, Jairo, additional, Ramirez, Deyanira A., additional, Caparó-Zamalloa, César, additional, Ciampi, Ethel, additional, Lana-Peixoto, Marco A., additional, Rodríguez, Emmanuel, additional, Zarco, Luis, additional, Sinay, Vladimiro, additional, Armas, Elizabeth, additional, Becker, Jefferson, additional, Benzadón, Aron, additional, Lopez, Ericka, additional, Carnero Contentti, Edgar, additional, Correa-Diaz, Edgar Patricio, additional, Diaz, Alejandro, additional, Fleitas, Cynthia Veronica, additional, Playas, Gil, additional, Molina, Omaira, additional, Rojas, Edgard, additional, Sato, Douglas, additional, Soto, Ibis, additional, Céspedes, Johana Vásquez, additional, Correale, Jorge, additional, Barboza, Andres, additional, Monterrey, Priscilla, additional, Candelario, Awilda, additional, Tavolini, Dario R., additional, Parajeles, Alexander, additional, Pujol, Biany Santos, additional, Diaz de la Fe, Amado, additional, Alonso, Ricardo, additional, Bolaña, Carlos, additional, Guzman, Marianne Kagi, additional, Carrá, Adriana, additional, Gamarra, Oscar Gonzalez, additional, Raggio, Jose Vera, additional, Rodriguez, Luis Cesar, additional, Ramirez, Nicia Eunice, additional, Ordoñez, Laura, additional, Skromne, Eli, additional, Portillo, Ligia lbeth, additional, Canabal, Alfredo Perez, additional, Weiser, Roberto, additional, Sirias, Vanessa, additional, Calderón, Ramiro Fernández, additional, Cornejo, Ernesto Arturo, additional, Hernández, Marianella, additional, Quiroz, Juan Carlos Duran, additional, Garcia, Luis Alberto, additional, Cedeño, Carlos Oviedo, additional, Martínez, Jorge, additional, and Abad-Herrera, Patricio, additional

Published
2021
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5. SARS-CoV-2 Infection and Risk Management in Multiple Sclerosis

Author

Diaz de la Fe, Amado, primary, Peláez Suárez, Alejandro Armando, additional, Fuentes Campos, Marinet, additional, Cabrera Hernández, Maivis Noemí, additional, Goncalves, Carlos-Alberto, additional, Schultz, Stephen, additional, Siniscalco, Dario, additional, and Robinson-Agramonte, Maria Angeles, additional

Published
2021
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6. HLA DRB1*/DQA1*Alleles and TNF-alpha G308A Polymorphism Protect against Neuromyelitis Optica in the Cuban Population

Author

Alberto Cintado, T. Diaz, J.A. Cabrera-Gómez, Jesús Benítez, H Camacho, M Nazabal, D Grass, Majel Cervantes-Llanos, Adelaida Villarreal, N Pavon-Fuentes, Mayte Ale, ME Fernández-de-Cossío, A Diaz de la Fe, and Giselle Pentón-Rol

Subjects
education.field_of_study, Neuromyelitis optica, Polymorphism (computer science), business.industry, Population, Immunology, medicine, Tumor necrosis factor alpha, Allele, education, medicine.disease, business, HLA-DRB1
Published
2018

7. HLA DRB1*/DQA1*Alleles and TNF-alpha G308A Polymorphism Protect against Neuromyelitis Optica in the Cuban Population

Author

Fernández-de-Cossío, ME, primary, Cintado, A, additional, Nazabal, M, additional, Camacho, H, additional, Díaz, T, additional, Villarreal, A, additional, Ale, M, additional, Grass, D, additional, Cervantes-Llanos, M, additional, Pavon-Fuentes, N, additional, Benitez, JV, additional, Cabrera-Gomez, JA, additional, Diaz de la Fe, A, additional, and Pentón-Rol, G, additional

Published
2018
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