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342 results on '"Diavatopoulos, Dimitri A."'

1. Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients

Author

den Hartog, Yvette, Malahe, S. Reshwan K., Rietdijk, Wim J. R., Dieterich, Marjolein, Gommers, Lennert, van Baarle, Debbie, Diavatopoulos, Dimitri A., Messchendorp, A. Lianne, van der Molen, Renate G., Remmerswaal, Ester B. M., Bemelman, Frederike J., Kho, Marcia M. L., GeurtsvanKessel, Corine H., Koopmans, Marion P. G., Gansevoort, Ron T., Hilbrands, Luuk B., Sanders, Jan-Stephan, Reinders, Marlies E. J., Baan, Carla C., and de Vries, Rory D.

Published
2024
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2. A novel whole blood assay to quantify the release of T cell associated cytokines in response to Bordetella pertussis antigens

Author

Diavatopoulos, Dimitri A., Mills, Kingston H.G., Kester, Kent E., Kampmann, Beate, Silerova, Marcela, Heininger, Ulrich, van Dongen, Jacques J.M., van der Most, Robbert G., Huijnen, Martijn A., Siena, Emilio, Mielcarek, Nathalie, Ochs, Martina M., Denoël, Philippe, Berbers, Guy, Buisman, Annemarie M., de Jonge, Marien I., Fenwick, Craig, Gorringe, Andrew, He, Qiushui, Kelly, Dominic, Le Grand, Roger, Locht, Camille, Mascart, Françoise, Mertsola, Jussi, Orfao, Alberto, Pantaleo, Giuseppe, Pollard, Andrew J., Preston, Andrew, Read, Robert, Sebo, Peter, van Els, Cecile, Vecerek, Branislav, Londoño-Hayes, Patricia, de Groot, Ronald, Pinto, Marta Valente, Barkoff, Alex-Mikael, Bibi, Sagida, Knuutila, Aapo, Teräsjärvi, Johanna, Clutterbuck, Elizabeth, Gimenez-Fourage, Sophie, Pagnon, Anke, van Gaans-van den Brink, Jacqueline A.M., Corbiere, Veronique, De Montfort, Aymeric, Saso, Anja, Jobe, Haddijatou, Roetynck, Sophie, Simonetti, Elles, Diavatopoulos, Dimitri, Lambert, Eleonora E., Blanc, Pascal, and van Els, Cécile A.C.M.

Published
2024
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3. Repeated COVID-19 Vaccination Drives Memory T- and B-cell Responses in Kidney Transplant Recipients: Results From a Multicenter Randomized Controlled Trial

Author

Malahe, S. Reshwan K., den Hartog, Yvette, Rietdijk, Wim J. R., van Baarle, Debbie, de Kuiper, Ronella, Reijerkerk, Derek, Ras, Alicia M., Geers, Daryl, Diavatopoulos, Dimitri A., Messchendorp, A. Lianne, van der Molen, Renate G., Imhof, Céline, Frölke, Sophie C., Bemelman, Frederike J., Gansevoort, Ron T., Hilbrands, Luuk B., Sanders, Jan-Stephan F., GeurtsvanKessel, Corine H., Kho, Marcia M. L., de Vries, Rory D., Reinders, Marlies E. J., Baan, Carla C., Abrahams, Alferso C., Baas, Marije C., Bouwmans, Pim, ten Dam, Marc A. G. J., Gommers, Lennert, Standaar, Dorien, van der Heiden, Marieke, Adema, Yvonne M. R., Boer-Verschragen, Marieken J, Mattheussens, Wouter B., Philipsen, Ria H. L. A., van Mourik, Djenolan, Bogers, Susanne, van Dijk, Laura L. A., Rots, Nynke, Hemmelder, Marc H., and de Vries, Aiko P. J.

Published
2024
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5. Th1-dominant cytokine responses in kidney patients after COVID-19 vaccination are associated with poor humoral responses

Author

den Hartog, Yvette, Malahe, S. Reshwan K., Rietdijk, Wim J. R., Dieterich, Marjolein, Gommers, Lennert, Geers, Daryl, Bogers, Susanne, van Baarle, Debbie, Diavatopoulos, Dimitri A., Messchendorp, A. Lianne, van der Molen, Renate G., Remmerswaal, Ester B. M., Bemelman, Frederike J., Gansevoort, Ron T., Hilbrands, Luuk B., Sanders, Jan-Stephan, GeurtsvanKessel, Corine H., Kho, Marcia M. L., Reinders, Marlies E. J., de Vries, Rory D., and Baan, Carla C.

Published
2023
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6. The role of interleukin-21 in COVID-19 vaccine–induced B cell–mediated immune responses in patients with kidney disease and kidney transplant recipients

Author

Abrahams, Alferso C., Baas, Marije C., Mattheussens, Wouter B., Philipsen, Ria H.L.A., Bouwmans, Pim, Hemmelder, Marc H., ten Dam, Marc A.G.J., Gommers, Lennert, Mourik, Djenolan van, Bogers, Susanne, van Dijk, Laura L.A., Standaar, Dorien, der Heiden, Marieke van, Adema, Yvonne M.R., Boer-Verschragen, Marieken J., Rots, Nynke, de Vries, Aiko P.J., Malahe, S. Reshwan K., Hartog, Yvette den, Rietdijk, Wim J.R., van Baarle, Debbie, de Kuiper, Ronella, Reijerkerk, Derek, Ras, Alicia M., Geers, Daryl, Diavatopoulos, Dimitri A., Messchendorp, A. Lianne, van der Molen, Renate G., Remmerswaal, Ester B.M., Bemelman, Frederike J., Gansevoort, Ron T., Hilbrands, Luuk B., Sanders, Jan-Stephan, GeurtsvanKessel, Corine H., Kho, Marcia M.L., de Vries, Rory D., Reinders, Marlies E.J., and Baan, Carla C.

Published
2023
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7. Alternative strategies to increase the immunogenicity of COVID-19 vaccines in kidney transplant recipients not responding to two or three doses of an mRNA vaccine (RECOVAC): a randomised clinical trial

Author

Abrahams, Alferso C., Baas, Marije C., Bouwmans, Pim, ten Dam, Marc A.G.J., Gommers, Lennert, Standaar, Dorien, van der Heiden, Marieke, Adema, Yvonne M.R., Boer-Verschragen, Marieken J., Mattheussens, Wouter B., Philipsen, Ria H.L.A., van Mourik, Djenolan, Bogers, Susanne, van Dijk, Laura L.A., Rots, Nynke, Smits, Gaby, Kuijer, Marjan, Hemmelder, Marc H., Kho, Marcia M L, Messchendorp, A Lianne, Frölke, Sophie C, Imhof, Celine, Koomen, Vera JCH, Malahe, S Reshwan K, Vart, Priya, Geers, Daryl, de Vries, Rory D, GeurtsvanKessel, Corine H, Baan, Carla C, van der Molen, Renate G, Diavatopoulos, Dimitri A, Remmerswaal, Ester B M, van Baarle, Debbie, van Binnendijk, Rob, den Hartog, Gerco, de Vries, Aiko P J, Gansevoort, Ron T, Bemelman, Frederike J, Reinders, Marlies E J, Sanders, Jan-Stephan F, and Hilbrands, Luuk B

Published
2023
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8. BCG-induced trained immunity enhances acellular pertussis vaccination responses in an explorative randomized clinical trial

Author

Gillard, Joshua, Blok, Bastiaan A., Garza, Daniel R., Venkatasubramanian, Prashanna Balaji, Simonetti, Elles, Eleveld, Marc J., Berbers, Guy A. M., van Gageldonk, Pieter G. M., Joosten, Irma, de Groot, Ronald, de Bree, L. Charlotte J., van Crevel, Reinout, de Jonge, Marien I., Huynen, Martijn A., Netea, Mihai G., and Diavatopoulos, Dimitri A.

Published
2022
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9. SARS-CoV-2 RNA in exhaled air of hospitalized COVID-19 patients

Author

Kurver, Lisa, van den Kieboom, Corné H., Lanke, Kjerstin, Diavatopoulos, Dimitri A., Overheul, Gijs J., Netea, Mihai G., ten Oever, Jaap, van Crevel, Reinout, Mulders-Manders, Karin, van de Veerdonk, Frank L., Wertheim, Heiman, Schouten, Jeroen, Rahamat-Langendoen, Janette, van Rij, Ronald P., Bousema, Teun, van Laarhoven, Arjan, and de Jonge, Marien I.

Published
2022
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12. Responses to an acellular pertussis booster vaccination in children, adolescents, and young and older adults: A collaborative study in Finland, the Netherlands, and the United Kingdom

Author

Versteegen, Pauline, Valente Pinto, Marta, Barkoff, Alex M., van Gageldonk, Pieter G.M., van de Kassteele, Jan, van Houten, Marlies A., Sanders, Elisabeth A.M., de Groot, Ronald, Diavatopoulos, Dimitri A., Bibi, Sagida, Luoto, Raakel, He, Qiushui, Buisman, Anne-Marie, Kelly, Dominic F., Mertsola, Jussi, and Berbers, Guy A.M.

Published
2021
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13. BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

Author

Moorlag, Simone J.C.F.M., Rodriguez-Rosales, Yessica Alina, Gillard, Joshua, Fanucchi, Stephanie, Theunissen, Kate, Novakovic, Boris, de Bont, Cynthia M., Negishi, Yutaka, Fok, Ezio T., Kalafati, Lydia, Verginis, Panayotis, Mourits, Vera P., Koeken, Valerie A.C.M., de Bree, L. Charlotte J., Pruijn, Ger J.M., Fenwick, Craig, van Crevel, Reinout, Joosten, Leo A.B., Joosten, Irma, Koenen, Hans, Mhlanga, Musa M., Diavatopoulos, Dimitri A., Chavakis, Triantafyllos, and Netea, Mihai G.

Published
2020
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14. SARS-CoV-2 Spike-specific IFN-γ T-cell Response After COVID-19 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant

Author

Imhof, Céline, Messchendorp, A. Lianne, van der Heiden, Marieke, Baan, Carla C., van der Molen, Renate G., Remmerswaal, Ester B. M., de Vries, Rory D., Diavatopoulos, Dimitri A., Boerma, Annemarie, Bakker, Femke J., Oosterhout, Emily, Bemelman, Frederike J., Hilbrands, Luuk B., Reinders, Marlies E. J., Gansevoort, Ron T., Sanders, Jan-Stephan, and van Baarle, Debbie

Published
2022
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15. Preliminary evidence of localizing CD8+ T-cell responses in COVID-19 patients with PET imaging

Author

Koenen, Hans J. P. M., primary, Kouijzer, Ilse J. E., additional, de Groot, Michel, additional, Peters, Steffie, additional, Lobeek, Daphne, additional, van Genugten, Evelien A. J., additional, Diavatopoulos, Dimitri A., additional, van Oosten, Nienke, additional, Gianotten, Sanne, additional, Prokop, Mathias M., additional, Netea, Mihai G., additional, van de Veerdonk, Frank L., additional, and Aarntzen, Erik H. J. G., additional

Published
2024
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16. Antiviral responses induced by Tdap-IPV vaccination are associated with persistent humoral immunity to Bordetella pertussis

Author

Gillard, Joshua, primary, Suffiotti, Madeleine, additional, Brazda, Peter, additional, Venkatasubramanian, Prashanna B., additional, Versteegen, Pauline, additional, de Jonge, Marien I., additional, Kelly, Dominic, additional, Bibi, Sagida, additional, Pinto, Marta Valente, additional, Simonetti, Elles, additional, Babiceanu, Mihaela, additional, Kettring, Andrew, additional, Teodosio, Cristina, additional, de Groot, Ronald, additional, Berbers, Guy, additional, Stunnenberg, Hendrik G., additional, Schanen, Brian, additional, Fenwick, Craig, additional, Huynen, Martijn A., additional, and Diavatopoulos, Dimitri A., additional

Published
2024
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17. Repeated COVID-19 Vaccination Drives Memory T- and B-cell Responses in Kidney Transplant Recipients:Results From a Multicenter Randomized Controlled Trial

Author

Malahe, S. Reshwan K., Den Hartog, Yvette, Rietdijk, Wim J.R., Van Baarle, Debbie, De Kuiper, Ronella, Reijerkerk, Derek, Ras, Alicia M., Geers, Daryl, Diavatopoulos, Dimitri A., Messchendorp, A. Lianne, Van Der Molen, Renate G., Imhof, Céline, Frölke, Sophie C., Bemelman, Frederike J., Gansevoort, Ron T., Hilbrands, Luuk B., Sanders, Jan Stephan F., Geurtsvankessel, Corine H., Kho, Marcia M.L., De Vries, Rory D., Reinders, Marlies E.J., Baan, Carla C., Malahe, S. Reshwan K., Den Hartog, Yvette, Rietdijk, Wim J.R., Van Baarle, Debbie, De Kuiper, Ronella, Reijerkerk, Derek, Ras, Alicia M., Geers, Daryl, Diavatopoulos, Dimitri A., Messchendorp, A. Lianne, Van Der Molen, Renate G., Imhof, Céline, Frölke, Sophie C., Bemelman, Frederike J., Gansevoort, Ron T., Hilbrands, Luuk B., Sanders, Jan Stephan F., Geurtsvankessel, Corine H., Kho, Marcia M.L., De Vries, Rory D., Reinders, Marlies E.J., and Baan, Carla C.

Published
2024

18. Antiviral responses induced by Tdap-IPV vaccination are associated with persistent humoral immunity to Bordetella pertussis

Author

CTI, CTI Sebestyen, Cancer, Infection & Immunity, Gillard, Joshua, Suffiotti, Madeleine, Brazda, Peter, Venkatasubramanian, Prashanna B., Versteegen, Pauline, de Jonge, Marien I., Kelly, Dominic, Bibi, Sagida, Pinto, Marta Valente, Simonetti, Elles, Babiceanu, Mihaela, Kettring, Andrew, Teodosio, Cristina, de Groot, Ronald, Berbers, Guy, Stunnenberg, Hendrik G., Schanen, Brian, Fenwick, Craig, Huynen, Martijn A., Diavatopoulos, Dimitri A., CTI, CTI Sebestyen, Cancer, Infection & Immunity, Gillard, Joshua, Suffiotti, Madeleine, Brazda, Peter, Venkatasubramanian, Prashanna B., Versteegen, Pauline, de Jonge, Marien I., Kelly, Dominic, Bibi, Sagida, Pinto, Marta Valente, Simonetti, Elles, Babiceanu, Mihaela, Kettring, Andrew, Teodosio, Cristina, de Groot, Ronald, Berbers, Guy, Stunnenberg, Hendrik G., Schanen, Brian, Fenwick, Craig, Huynen, Martijn A., and Diavatopoulos, Dimitri A.

Published
2024

19. Primary Exposure to SARS-CoV-2 via Infection or Vaccination Determines Mucosal Antibody-Dependent ACE2 Binding Inhibition

Author

Fröberg, Janeri, Koomen, Vera J.C.H., Van Der Gaast-De Jongh, Christa E., Philipsen, Ria, Geurtsvankessel, Corine H., De Vries, Rory D., Baas, Marije C., Van Der Molen, Renate G., De Jonge, Marien I., Hilbrands, Luuk B., Huynen, Martijn A., Diavatopoulos, Dimitri A., Fröberg, Janeri, Koomen, Vera J.C.H., Van Der Gaast-De Jongh, Christa E., Philipsen, Ria, Geurtsvankessel, Corine H., De Vries, Rory D., Baas, Marije C., Van Der Molen, Renate G., De Jonge, Marien I., Hilbrands, Luuk B., Huynen, Martijn A., and Diavatopoulos, Dimitri A.

Abstract

Background: Mucosal antibodies play a critical role in preventing SARS-CoV-2 infections or reinfections by blocking the interaction of the receptor-binding domain (RBD) with the angiotensin-converting enzyme 2 (ACE2) receptor on the cell surface. In this study, we investigated the difference between the mucosal antibody response after primary infection and vaccination. Methods: We assessed longitudinal changes in the quantity and capacity of nasal antibodies to neutralize the interaction of RBD with the ACE2 receptor using the spike protein and RBD from ancestral SARS-CoV-2 (Wuhan-Hu-1), as well as the RBD from the Delta and Omicron variants. Results: Significantly higher mucosal IgA concentrations were detected postinfection vs postvaccination, while vaccination induced higher IgG concentrations. However, ACE2-inhibiting activity did not differ between the cohorts. Regarding whether IgA or IgG drove ACE2 inhibition, infection-induced binding inhibition was driven by both isotypes, while postvaccination binding inhibition was mainly driven by IgG. Conclusions: Our study provides new insights into the relationship between antibody isotypes and neutralization by using a sensitive and high-Throughput ACE2 binding inhibition assay. Key differences are highlighted between vaccination and infection at the mucosal level, showing that despite differences in the response quantity, postinfection and postvaccination ACE2 binding inhibition capacity did not differ.

Published
2024

21. The RECOVAC Immune-response Study: The Immunogenicity, Tolerability, and Safety of COVID-19 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant

Author

Sanders, Jan-Stephan F., Bemelman, Frederike J., Messchendorp, A. Lianne, Baan, Carla C., van Baarle, Debbie, van Binnendijk, Rob, Diavatopoulos, Dimitri A., Frölke, Sophie C., Geers, Daryl, GeurtsvanKessel, Corine H., den Hartog, Gerco, van der Heiden, Marieke, Imhof, Celine, Kho, Marcia M. L., Koopmans, Marion P. G., Malahe, S. Reshwan K., Mattheussens, Wouter B., van der Molen, Renate, van Mourik, Djenolan, Remmerswaal, Ester B. M., Rots, Nynke, Vart, Priya, de Vries, Rory D., Gansevoort, Ron T., Hilbrands, Luuk B., and Reinders, Marlies E. J.

Published
2021
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22. SARS-CoV-2 mucosal antibody development and persistence and their relation to viral load and COVID-19 symptoms

Author

Fröberg, Janeri, Gillard, Joshua, Philipsen, Ria, Lanke, Kjerstin, Rust, Joyce, van Tuijl, Diana, Teelen, Karina, Bousema, Teun, Simonetti, Elles, van der Gaast-de Jongh, Christa E., Bos, Mariska, van Kuppeveld, Frank J., Bosch, Berend-Jan, Nabuurs-Franssen, Marrigje, van der Geest-Blankert, Nannet, van Daal, Charlotte, Huynen, Martijn A., de Jonge, Marien I., and Diavatopoulos, Dimitri A.

Published
2021
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23. PERISCOPE: road towards effective control of pertussis

Author

Diavatopoulos, Dimitri A., Mills, Kingston H.G., Kester, Kent E., Kampmann, Beate, Silerova, Marcela, Heininger, Ulrich, van Dongen, Jacques J.M., van der Most, Robbert G., Huijnen, Martijn A., Siena, Emilio, Mielcarek, Nathalie, Ochs, Martina M., Denoël, Philippe, Berbers, Guy, Buisman, Annemarie M., de Jonge, Marien I., Fenwick, Craig, Gorringe, Andrew, He, Qiushui, Kelly, Dominic, Le Grand, Roger, Locht, Camille, Mascart, Françoise, Mertsola, Jussi, Orfao, Alberto, Pantaleo, Giuseppe, Pollard, Andrew J., Preston, Andrew, Read, Robert, Sebo, Peter, van Els, Cecile, Vecerek, Branislav, Londoño-Hayes, Patricia, and de Groot, Ronald

Published
2019
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25. Primary Exposure to SARS-CoV-2 via Infection or Vaccination Determines Mucosal Antibody-Dependent ACE2 Binding Inhibition

Author

Fröberg, Janeri, primary, Koomen, Vera J C H, additional, van der Gaast-de Jongh, Christa E, additional, Philipsen, Ria, additional, GeurtsvanKessel, Corine H, additional, de Vries, Rory D, additional, Baas, Marije C, additional, van der Molen, Renate G, additional, de Jonge, Marien I, additional, Hilbrands, Luuk B, additional, Huynen, Martijn A, additional, and Diavatopoulos, Dimitri A, additional

Published
2023
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26. The role of interleukin-21 in COVID-19 vaccine–induced B cell–mediated immune responses in patients with kidney disease and kidney transplant recipients

Author

Malahe, S. Reshwan K., primary, Hartog, Yvette den, additional, Rietdijk, Wim J.R., additional, van Baarle, Debbie, additional, de Kuiper, Ronella, additional, Reijerkerk, Derek, additional, Ras, Alicia M., additional, Geers, Daryl, additional, Diavatopoulos, Dimitri A., additional, Messchendorp, A. Lianne, additional, van der Molen, Renate G., additional, Remmerswaal, Ester B.M., additional, Bemelman, Frederike J., additional, Gansevoort, Ron T., additional, Hilbrands, Luuk B., additional, Sanders, Jan-Stephan, additional, GeurtsvanKessel, Corine H., additional, Kho, Marcia M.L., additional, de Vries, Rory D., additional, Reinders, Marlies E.J., additional, Baan, Carla C., additional, Abrahams, Alferso C., additional, Baas, Marije C., additional, Mattheussens, Wouter B., additional, Philipsen, Ria H.L.A., additional, Bouwmans, Pim, additional, Hemmelder, Marc H., additional, ten Dam, Marc A.G.J., additional, Gommers, Lennert, additional, Mourik, Djenolan van, additional, Bogers, Susanne, additional, van Dijk, Laura L.A., additional, Standaar, Dorien, additional, der Heiden, Marieke van, additional, Adema, Yvonne M.R., additional, Boer-Verschragen, Marieken J., additional, Rots, Nynke, additional, and de Vries, Aiko P.J., additional

Published
2023
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28. Host and Environmental Factors Influencing Individual Human Cytokine Responses

Author

ter Horst, Rob, Jaeger, Martin, Smeekens, Sanne P., Oosting, Marije, Swertz, Morris A., Li, Yang, Kumar, Vinod, Diavatopoulos, Dimitri A., Jansen, Anne F.M., Lemmers, Heidi, Toenhake-Dijkstra, Helga, van Herwaarden, Antonius E., Janssen, Matthijs, van der Molen, Renate G., Joosten, Irma, Sweep, Fred C.G.J., Smit, Johannes W., Netea-Maier, Romana T., Koenders, Mieke M.J.F., Xavier, Ramnik J., van der Meer, Jos W.M., Dinarello, Charles A., Pavelka, Norman, Wijmenga, Cisca, Notebaart, Richard A., Joosten, Leo A.B., and Netea, Mihai G.

Published
2016
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30. The Role of Interleukin-21 in COVID-19 Vaccine-Induced B Cell-Mediated Immune Responses in Kidney Disease Patients and Kidney Transplant Recipients

Author

Malahe, S Reshwan K, den Hartog, Yvette, Rietdijk, Wim J R, van Baarle, Debbie, de Kuiper, Ronella, Reijerkerk, Derek, Ras, Alicia M, Geers, Daryl, Diavatopoulos, Dimitri A, Messchendorp, A Lianne, van der Molen, Renate G, Remmerswaal, Ester B M, Bemelman, Frederike J, Gansevoort, Ron T, Hilbrands, Luuk B, Sanders, Jan-Stephan, GeurtsvanKessel, Corine H, Kho, Marcia M L, de Vries, Rory D, Reinders, Marlies E J, and Baan, Carla C

Abstract

T cell mediated help to B cells is required for the development of humoral responses, in which the cytokine interleukin (IL)-21 is key. Here, we studied the mRNA-1273 vaccine-induced SARS-CoV-2-specific memory T cell IL-21 response, memory B cell response and IgG antibody levels in peripheral blood at 28 days after the 2nd vaccination by ELISpot and the fluorescent bead-based multiplex-immunoassay, respectively. We included 40 chronic kidney disease (CKD) patients, 34 patients on dialysis, 63 kidney transplant recipients (KTR) and 47 controls. We found that KTR, but not CKD and dialysis patients, had a significantly lower number of SARS-CoV-2-specific IL-21 producing T cells than controls (p

Published
2023

31. Antibody and T-Cell Responses 6 Months after Coronavirus Disease 2019 Messenger RNA-1273 Vaccination in Patients with Chronic Kidney Disease, on Dialysis, or Living with a Kidney Transplant

Author

Sanders, Jan Stephan F, Lianne Messchendorp, A, de Vries, Rory D, Baan, Carla C, van Baarle, Debbie, van Binnendijk, Rob, Diavatopoulos, Dimitri A, Geers, Daryl, Schmitz, Katharina S, van Kessel, Corine H Geurts, Hartog, Gerco den, Kho, Marcia Ml, Koopmans, Marion Pg, van der Molen, Renate G, Remmerswaal, Ester Bm, Rots, Nynke, Gansevoort, Ron T, Bemelman, Frederike J, Hilbrands, Luuk B, Reinders, Marlies Ej, Sanders, Jan Stephan F, Lianne Messchendorp, A, de Vries, Rory D, Baan, Carla C, van Baarle, Debbie, van Binnendijk, Rob, Diavatopoulos, Dimitri A, Geers, Daryl, Schmitz, Katharina S, van Kessel, Corine H Geurts, Hartog, Gerco den, Kho, Marcia Ml, Koopmans, Marion Pg, van der Molen, Renate G, Remmerswaal, Ester Bm, Rots, Nynke, Gansevoort, Ron T, Bemelman, Frederike J, Hilbrands, Luuk B, and Reinders, Marlies Ej

Published
2023

32. The role of interleukin-21 in COVID-19 vaccine–induced B cell–mediated immune responses in patients with kidney disease and kidney transplant recipients

Author

Malahe, S. Reshwan K., Hartog, Yvette den, Rietdijk, Wim J.R., van Baarle, Debbie, de Kuiper, Ronella, Reijerkerk, Derek, Ras, Alicia M., Geers, Daryl, Diavatopoulos, Dimitri A., Messchendorp, A. Lianne, van der Molen, Renate G., Remmerswaal, Ester B.M., Bemelman, Frederike J., Gansevoort, Ron T., Hilbrands, Luuk B., Sanders, Jan Stephan, GeurtsvanKessel, Corine H., Kho, Marcia M.L., de Vries, Rory D., Reinders, Marlies E.J., Baan, Carla C., Malahe, S. Reshwan K., Hartog, Yvette den, Rietdijk, Wim J.R., van Baarle, Debbie, de Kuiper, Ronella, Reijerkerk, Derek, Ras, Alicia M., Geers, Daryl, Diavatopoulos, Dimitri A., Messchendorp, A. Lianne, van der Molen, Renate G., Remmerswaal, Ester B.M., Bemelman, Frederike J., Gansevoort, Ron T., Hilbrands, Luuk B., Sanders, Jan Stephan, GeurtsvanKessel, Corine H., Kho, Marcia M.L., de Vries, Rory D., Reinders, Marlies E.J., and Baan, Carla C.

Abstract

T-cell–mediated help to B cells is required for the development of humoral responses, in which the cytokine interleukin (IL)-21 is key. Here, we studied the mRNA-1273 vaccine–induced SARS-CoV-2–specific memory T-cell IL-21 response, memory B cell response, and immunoglobulin (Ig)G antibody levels in peripheral blood at 28 days after the second vaccination by ELISpot and the fluorescent bead–based multiplex immunoassay, respectively. We included 40 patients with chronic kidney disease (CKD), 34 patients on dialysis, 63 kidney transplant recipients (KTR), and 47 controls. We found that KTR, but not patients with CKD and those receiving dialysis, showed a significantly lower number of SARS-CoV-2–specific IL-21 producing T cells than controls (P < .001). KTR and patients with CKD showed lower numbers of SARS-CoV-2–specific IgG–producing memory B cells when compared with controls (P < .001 and P = .01, respectively). The T-cell IL-21 response was positively associated with the SARS-CoV-2–specific B cell response and the SARS-CoV-2 spike S1–specific IgG antibody levels (both Pearson r = 0.5; P < .001). In addition, SARS-CoV-2–specific B cell responses were shown to be IL-21 dependent. Taken together, we show that IL-21 signaling is important in eliciting robust B cell–mediated immune responses in patients with kidney disease and KTR.

Published
2023

33. Alternative strategies to increase the immunogenicity of COVID-19 vaccines in kidney transplant recipients not responding to two or three doses of an mRNA vaccine (RECOVAC): a randomised clinical trial

Author

Kho, Marcia M L, primary, Messchendorp, A Lianne, additional, Frölke, Sophie C, additional, Imhof, Celine, additional, Koomen, Vera JCH, additional, Malahe, S Reshwan K, additional, Vart, Priya, additional, Geers, Daryl, additional, de Vries, Rory D, additional, GeurtsvanKessel, Corine H, additional, Baan, Carla C, additional, van der Molen, Renate G, additional, Diavatopoulos, Dimitri A, additional, Remmerswaal, Ester B M, additional, van Baarle, Debbie, additional, van Binnendijk, Rob, additional, den Hartog, Gerco, additional, de Vries, Aiko P J, additional, Gansevoort, Ron T, additional, Bemelman, Frederike J, additional, Reinders, Marlies E J, additional, Sanders, Jan-Stephan F, additional, Hilbrands, Luuk B, additional, Abrahams, Alferso C., additional, Baas, Marije C., additional, Bouwmans, Pim, additional, ten Dam, Marc A.G.J., additional, Gommers, Lennert, additional, Standaar, Dorien, additional, van der Heiden, Marieke, additional, Adema, Yvonne M.R., additional, Boer-Verschragen, Marieken J., additional, Mattheussens, Wouter B., additional, Philipsen, Ria H.L.A., additional, van Mourik, Djenolan, additional, Bogers, Susanne, additional, van Dijk, Laura L.A., additional, Rots, Nynke, additional, Smits, Gaby, additional, Kuijer, Marjan, additional, and Hemmelder, Marc H., additional

Published
2023
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35. A semi high-throughput whole blood-based flow cytometry assay to detect and monitor -specific Th1, Th2 and Th17 responses

Author

Corbière, Véronique, Lambert, Eleonora E, Rodesch, Marine, van Gaans-van den Brink, Jacqueline A M, Misiak, Alicja, Simonetti, Elles, Van Praet, Anne, Godefroid, Audrey, Diavatopoulos, Dimitri A, van Els, Cécile A C M, and Mascart, Françoise

Subjects
flow cytometry, vaccine, intracellular cytokine staining, Th1/Th2/Th17, Bordetella pertussis, whole blood assay
Abstract

The characterization of B. pertussis (Bp) antigen-specific CD4+ T cell cytokine responses should be included in the evaluation of immunogenicity of pertussis vaccines but is often hindered by the lack of standardized robust assays.

Published
2023

36. Antibody and T-cell responses 6 months after COVID-19 mRNA-1273 vaccination in patients with chronic kidney disease, on dialysis, or living with a kidney transplant

Author

Sanders, Jan Stephan F, Lianne Messchendorp, A, de Vries, Rory D, Baan, Carla C, van Baarle, Debbie, van Binnendijk, Rob, Diavatopoulos, Dimitri A, Geers, Daryl, Schmitz, Katharina S, van Kessel, Corine H Geurts, Hartog, Gerco den, Kho, Marcia Ml, Koopmans, Marion Pg, van der Molen, Renate G, Remmerswaal, Ester Bm, Rots, Nynke, Gansevoort, Ron T, Bemelman, Frederike J, Hilbrands, Luuk B, Reinders, Marlies Ej, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Translational Immunology Groningen (TRIGR), and Cardiovascular Centre (CVC)

Abstract

BACKGROUND: The immune response to COVID-19 vaccination is inferior in kidney transplant recipients (KTR), and to a lesser extent in patients on dialysis or with chronic kidney disease (CKD). We assessed the immune response 6 months after mRNA-1273 vaccination in kidney patients and compared this to controls. METHODS: 152 participants with CKD stages G4/5 (eGFR

Published
2023

39. SARS-CoV-2 Spike-specific IFN-gamma T-cell Response After COVID-19 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant

Author

Imhof, Céline, Messchendorp, A Lianne, van der Heiden, Marieke, Baan, Carla C, van der Molen, Renate G, Remmerswaal, Ester B M, de Vries, Rory D, Diavatopoulos, Dimitri A, Boerma, Annemarie, Bakker, Femke J, Oosterhout, Emily, Bemelman, Frederike J, Hilbrands, Luuk B, Reinders, Marlies E J, Gansevoort, Ron T, Sanders, Jan-Stephan, van Baarle, Debbie, Imhof, Céline, Messchendorp, A Lianne, van der Heiden, Marieke, Baan, Carla C, van der Molen, Renate G, Remmerswaal, Ester B M, de Vries, Rory D, Diavatopoulos, Dimitri A, Boerma, Annemarie, Bakker, Femke J, Oosterhout, Emily, Bemelman, Frederike J, Hilbrands, Luuk B, Reinders, Marlies E J, Gansevoort, Ron T, Sanders, Jan-Stephan, and van Baarle, Debbie

Published
2022

40. The RECOVAC Immune-response Study:The Immunogenicity, Tolerability, and Safety of COVID-19 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant

Author

Sanders, Jan-Stephan F, Bemelman, Frederike J, Messchendorp, A Lianne, Baan, Carla C, van Baarle, Debbie, van Binnendijk, Rob, Diavatopoulos, Dimitri A, Frölke, Sophie C, Geers, Daryl, GeurtsvanKessel, Corine H, den Hartog, Gerco, van der Heiden, Marieke, Imhof, Celine, Kho, Marcia M L, Koopmans, Marion P G, Malahe, S Reshwan K, Mattheussens, Wouter B, van der Molen, Renate, van Mourik, Djenolan, Remmerswaal, Ester B M, Rots, Nynke, Vart, Priya, de Vries, Rory D, Gansevoort, Ron T, Hilbrands, Luuk B, Reinders, Marlies E J, Sanders, Jan-Stephan F, Bemelman, Frederike J, Messchendorp, A Lianne, Baan, Carla C, van Baarle, Debbie, van Binnendijk, Rob, Diavatopoulos, Dimitri A, Frölke, Sophie C, Geers, Daryl, GeurtsvanKessel, Corine H, den Hartog, Gerco, van der Heiden, Marieke, Imhof, Celine, Kho, Marcia M L, Koopmans, Marion P G, Malahe, S Reshwan K, Mattheussens, Wouter B, van der Molen, Renate, van Mourik, Djenolan, Remmerswaal, Ester B M, Rots, Nynke, Vart, Priya, de Vries, Rory D, Gansevoort, Ron T, Hilbrands, Luuk B, and Reinders, Marlies E J

Abstract

BACKGROUND: In kidney patients COVID-19 is associated with severely increased morbidity and mortality. A comprehensive comparison of the immunogenicity, tolerability, and safety of COVID-19 vaccination in different cohorts of kidney patients and a control cohort is lacking.METHODS: This investigator driven, prospective, controlled multicenter study included 162 participants with chronic kidney disease (CKD) stages G4/5 (eGFR < 30 mL/min/1.73m2), 159 participants on dialysis, 288 kidney transplant recipients, and 191 controls. Participants received 2 doses of the mRNA-1273 COVID-19 vaccine (Moderna). The primary endpoint was seroconversion.RESULTS: Transplant recipients had a significantly lower seroconversion rate when compared with controls (56.9% versus 100%, P < 0.001), with especially mycophenolic acid, but also, higher age, lower lymphocyte concentration, lower eGFR, and shorter time after transplantation being associated with nonresponder state. Transplant recipients also showed significantly lower titers of neutralizing antibodies and T-cell responses when compared with controls. Although a high seroconversion rate was observed for participants with CKD G4/5 (100%) and on dialysis (99.4%), mean antibody concentrations in the CKD G4/5 cohort and dialysis cohort were lower than in controls (2405 [interquartile interval 1287-4524] and 1650 [698-3024] versus 3186 [1896-4911] BAU/mL, P = 0.06 and P < 0.001, respectively). Dialysis patients and especially kidney transplant recipients experienced less systemic vaccination related adverse events. No specific safety issues were noted.CONCLUSIONS: The immune response following vaccination in patients with CKD G4/5 and on dialysis is almost comparable to controls. In contrast, kidney transplant recipients have a poor response. In this latter, patient group development of alternative vaccination strategies are warranted.

Published
2022

41. Multi-Omics Integration Reveals Only Minor Long-Term Molecular and Functional Sequelae in Immune Cells of Individuals Recovered From COVID-19

Author

Liu, Zhaoli, primary, Kilic, Gizem, additional, Li, Wenchao, additional, Bulut, Ozlem, additional, Gupta, Manoj Kumar, additional, Zhang, Bowen, additional, Qi, Cancan, additional, Peng, He, additional, Tsay, Hsin-Chieh, additional, Soon, Chai Fen, additional, Mekonnen, Yonatan Ayalew, additional, Ferreira, Anaísa Valido, additional, van der Made, Caspar I., additional, van Cranenbroek, Bram, additional, Koenen, Hans J. P. M., additional, Simonetti, Elles, additional, Diavatopoulos, Dimitri, additional, de Jonge, Marien I., additional, Müller, Lisa, additional, Schaal, Heiner, additional, Ostermann, Philipp N., additional, Cornberg, Markus, additional, Eiz-Vesper, Britta, additional, van de Veerdonk, Frank, additional, van Crevel, Reinout, additional, Joosten, Leo A. B., additional, Domínguez-Andrés, Jorge, additional, Xu, Cheng-Jian, additional, Netea, Mihai G., additional, and Li, Yang, additional

Published
2022
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42. Immunogenicity and safety of COVID-19 vaccination in patients with primary Sjögren’s syndrome

Author

Verstappen, Gwenny M, primary, de Wolff, Liseth, additional, Arends, Suzanne, additional, Heiermann, Hella-Marie, additional, van Sleen, Yannick, additional, Visser, Annie, additional, Terpstra, Janneke H, additional, Diavatopoulos, Dimitri A, additional, van der Heiden, Marieke, additional, Vissink, Arjan, additional, van Baarle, Debbie, additional, Kroese, Frans G M, additional, and Bootsma, Hendrika, additional

Published
2022
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43. Th1-dominant cytokine responses in kidney patients after COVID-19 vaccination are associated with poor humoral responses.

Author

den Hartog, Yvette, Malahe, S. Reshwan K., Rietdijk, Wim J. R., Dieterich, Marjolein, Gommers, Lennert, Geers, Daryl, Bogers, Susanne, van Baarle, Debbie, Diavatopoulos, Dimitri A., Messchendorp, A. Lianne, van der Molen, Renate G., Remmerswaal, Ester B. M., Bemelman, Frederike J., Gansevoort, Ron T., Hilbrands, Luuk B., Sanders, Jan-Stephan, GeurtsvanKessel, Corine H., Kho, Marcia M. L., Reinders, Marlies E. J., and de Vries, Rory D.

Subjects
HUMORAL immunity, T cells, SARS-CoV-2, COVID-19 vaccines, IMMUNOGLOBULINS, IMMUNOLOGIC memory, T cell receptors, CYTOKINE receptors
Abstract

Cytokines are regulators of the immune response against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, the contribution of cytokine-secreting CD4+ and CD8+ memory T cells to the SARS-CoV-2-specific humoral immune response in immunocompromised kidney patients is unknown. Here, we profiled 12 cytokines after stimulation of whole blood obtained 28 days post second 100 μg mRNA-1273 vaccination with peptides covering the SARS-CoV-2 spike (S)-protein from patients with chronic kidney disease (CKD) stage 4/5, on dialysis, kidney transplant recipients (KTR), and healthy controls. Unsupervised hierarchical clustering analysis revealed two distinct vaccine-induced cytokine profiles. The first profile was characterized by high levels of T-helper (Th)1 (IL-2, TNF-α, and IFN-γ) and Th2 (IL-4, IL-5, IL-13) cytokines, and low levels of Th17 (IL-17A, IL-22) and Th9 (IL-9) cytokines. This cluster was dominated by patients with CKD, on dialysis, and healthy controls. In contrast, the second cytokine profile contained predominantly KTRs producing mainly Th1 cytokines upon re-stimulation, with lower levels or absence of Th2, Th17, and Th9 cytokines. Multivariate analyses indicated that a balanced memory T cell response with the production of Th1 and Th2 cytokines was associated with high levels of S1-specific binding and neutralizing antibodies mainly at 6 months after second vaccination. In conclusion, seroconversion is associated with the balanced production of cytokines by memory T cells. This emphasizes the importance of measuring multiple T cell cytokines to understand their influence on seroconversion and potentially gain more information about the protection induced by vaccine-induced memory T cells. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Alternative Strategies to Increase the Immunogenicity of Covid-19 Vaccines in Kidney Transplant Recipients Not Responding to Two or Three Doses of an mRNA Vaccine. A Randomized Clinical Trial

Author

Kho, Marcia ML, primary, Messchendorp, A. Lianne, additional, Frölke, Sophie, additional, Imhof, Celine, additional, Koomen, Vera JCH, additional, Malahe, S. Reshwan K., additional, Geers, Daryl, additional, Baan, Carla C., additional, Van der molen, Renate, additional, Diavatopoulos, Dimitri A., additional, Remmerswaal, Ester, additional, van Baarle, Debbie, additional, van Binnendijk, Robert Samuel, additional, den Hartog, Gerco, additional, Gansevoort, Ron T., additional, Bemelman, Frederike J., additional, Reinders, Marlies EJ, additional, Sanders, Jan-Stephan, additional, Hilbrands, Luuk B., additional, and Collaborators, RECOVAC, additional

Published
2022
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45. Antibody and T-Cell Responses 6 Months after Covid-19 mRNA-1273 Vaccination in Patients with Chronic Kidney Disease, on Dialysis, or Living with a Kidney Transplant

Author

Sanders, Jan-Stephan, primary, Messchendorp, A. Lianne, additional, de Vries, Rory, additional, Baan, Carla C., additional, van Baarle, Debbie, additional, van Binnendijk, Robert Samuel, additional, Diavatopoulos, Dimitri A., additional, Geers, Daryl, additional, Schmitz, Katharina S., additional, GeurtsvanKessel, Corine, additional, den Hartog, Gerco, additional, Kho, Marcia ML, additional, Koopmans, Marion, additional, Van der molen, Renate, additional, Remmerswaal, Ester, additional, Rots, Nynke, additional, Gansevoort, Ron T., additional, Bemelman, Frederike J., additional, Hilbrands, Luuk B., additional, Reinders, Marlies EJ, additional, and Collaborators, RECOVAC, additional

Published
2022
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46. Corrigendum to ‘Responses to an acellular pertussis booster vaccination in children, adolescents, and young and older adults: A collaborative study in Finland, the Netherlands, and the United Kingdom’

Author

Versteegen, Pauline, Pinto, Marta Valente, Barkoff, Alex M., van Gageldonk, Pieter G.M., Kassteele, Jan van de, van Houten, Marlies A., Sanders, Elisabeth A.M., de Groot, Ronald, Diavatopoulos, Dimitri A., Bibi, Sagida, Luoto, Raakel, He, Qiushui, Buisman, Anne-Marie, Kelly, Dominic F., Mertsola, Jussi, and Berbers, Guy A.M.

Published
2021
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48. A semi high-throughput whole blood-based flow cytometry assay to detect and monitor Bordetella pertussis-specific Th1, Th2 and Th17 responses.

Author

Corbière, Véronique, Lambert, Eleonora E., Rodesch, Marine, van Gaans-van den Brink, Jacqueline A. M., Misiak, Alicja, Simonetti, Elles, Van Praet, Anne, Godefroid, Audrey, Diavatopoulos, Dimitri A., van Els, Cécile A. C. M., and Mascart, Françoise

Subjects
FLOW cytometry, PERTUSSIS toxin, T cells, CRYOPRESERVATION of cells, WHOOPING cough vaccines
Abstract

Introduction: The characterization of B. pertussis (Bp) antigen-specific CD4+ T cell cytokine responses should be included in the evaluation of immunogenicity of pertussis vaccines but is often hindered by the lack of standardized robust assays. Methods: To overcome this limitation, we developed a two-step assay comprising a short-term stimulation of fresh whole blood with Bp antigens and cryopreservation of the stimulated cells, followed later on by batch-wise intracellular cytokine analysis by flow cytometry. Blood samples collected from recently acellular (aP) vaccine boosted subjects with a whole-cell- or aP-primed background was incubated for 24 hrs with Pertussis toxin, Filamentous hemagglutinin or a Bp lysate (400µl per stimulation). Antigen-specific IFN-g-, IL-4/IL-5/IL-13-, IL-17A/IL-17F-and/or IL-22-producing CD4+ T cells were quantified by flow cytometry to reveal Th1, Th2, and Th17-type responses, respectively. The frequencies of IFN-g-producing CD8+ T cells were also analyzed. Results: We demonstrate high reproducibility of the Bp-specific whole blood intracellular staining assay. The results obtained after cryopreservation of the stimulated and fixed cells were very well correlated to those obtained without cryopreservation, an approach used in our previously published assay. Optimization resulted in high sensitivity thanks to very low non-specific backgrounds, with reliable detection of Bp antigen-specific Th1, Th2 and Th17-type CD4+ T cells, in the lowest range frequency of 0.01-0.03%. Bp antigenspecific IFN-g+ CD8+ T lymphocytes were also detected. This test is easy to perform, analyse and interpret with the establishment of strict criteria defining Bp antigen responses. Discussion: Thus, this assay appears as a promising test for evaluation of Bp antigen-specific CD4+ T cells induced by current and next generation pertussis vaccines. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Antibody and T-Cell Responses 6 Months After Coronavirus Disease 2019 Messenger RNA-1273 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant.

Author

Sanders, Jan-Stephan F, Messchendorp, A Lianne, Vries, Rory D de, Baan, Carla C, Baarle, Debbie van, Binnendijk, Rob van, Diavatopoulos, Dimitri A, Geers, Daryl, Schmitz, Katharina S, GeurtsvanKessel, Corine H, Hartog, Gerco den, Kho, Marcia M L, Koopmans, Marion P G, Molen, Renate G van der, Remmerswaal, Ester B M, Rots, Nynke, Gansevoort, Ron T, Bemelman, Frederike J, Hilbrands, Luuk B, and Reinders, Marlies E J

Subjects
TREATMENT of chronic kidney failure, IMMUNOGLOBULINS, COVID-19, COVID-19 vaccines, KIDNEY transplantation, PATIENTS, COMPARATIVE studies, INTERFERONS, MESSENGER RNA, IMMUNITY, RESEARCH funding, T cells, HEMODIALYSIS, TRANSPLANTATION of organs, tissues, etc.
Abstract

Background The immune response to COVID-19 vaccination is inferior in kidney transplant recipients (KTRs) and to a lesser extent in patients on dialysis or with chronic kidney disease (CKD). We assessed the immune response 6 months after mRNA-1273 vaccination in kidney patients and compared this to controls. Methods A total of 152 participants with CKD stages G4/5 (eGFR <30 mL/min/1.73 m2), 145 participants on dialysis, 267 KTRs, and 181 controls were included. SARS-CoV-2 Spike S1 specific IgG antibodies were measured using fluorescent bead-based multiplex-immunoassay, neutralizing antibodies to ancestral, Delta, and Omicron (BA.1) variants by plaque reduction, and T-cell responses by interferon- γ release assay. Results At 6 months after vaccination, S1-specific antibodies were detected in 100% of controls, 98.7% of CKD G4/5 patients, 95.1% of dialysis patients, and 56.6% of KTRs. These figures were comparable to the response rates at 28 days, but antibody levels waned significantly. Neutralization of the ancestral and Delta variants was detected in most participants, whereas neutralization of Omicron was mostly absent. S-specific T-cell responses were detected at 6 months in 75.0% of controls, 69.4% of CKD G4/5 patients, 52.6% of dialysis patients, and 12.9% of KTRs. T-cell responses at 6 months were significantly lower than responses at 28 days. Conclusions Although seropositivity rates at 6 months were comparable to rates at 28 days after vaccination, significantly decreased antibody levels and T-cell responses were observed. The combination of low antibody levels, reduced T-cell responses, and absent neutralization of the newly emerging variants indicates the need for additional boosts or alternative vaccination strategies in KTRs. Clinical Trials Registration NCT04741386. [ABSTRACT FROM AUTHOR]

Published
2023
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50. List of Contributors

Author

Agarwal, Vaibhav, primary, Bergmann, Simone, additional, Bootsma, Hester J., additional, Brown, Jeremy S., additional, Carriço, Joáo A., additional, Chancey, Scott, additional, Denapaite, Dalia, additional, de Paz, Hector D., additional, Diavatopoulos, Dimitri A., additional, Dockrell, David H., additional, Durmort, Claire, additional, Ferreira, Daniela M., additional, Finn, Adam, additional, Fobiwe, John P., additional, Galán-Bartual, Sergio, additional, Gámez, Gustavo, additional, García, Pedro, additional, Gisch, Nicolas, additional, Gordon, Stephen B., additional, Gratz, Nina, additional, Hakansson, Anders P., additional, Hakenbeck, Regine, additional, Hammerschmidt, Sven, additional, Hermans, Peter W.M., additional, Hermoso, Juan A., additional, Hilleringmann, Markus, additional, Infante, Anthony J., additional, Kadioglu, Aras, additional, Kietzman, Colin C., additional, Klugman, Keith P., additional, Kohler, Sylvia, additional, Loh, Lip Nam, additional, Malley, Rick, additional, Marks, Laura R., additional, McCullers, Jonathan A., additional, McGee, Lesley, additional, Melo-Cristino, José, additional, Mitchell, Timothy J., additional, Morona, Renato, additional, Muñoz-Almagro, Carmen, additional, Neill, Daniel R., additional, Oggioni, Marco R., additional, Ogunniyi, Abiodun D., additional, Oliver, Melissa B., additional, Orihuela, Carlos J., additional, Paton, James C., additional, Pérez-Dorado, Inmaculada, additional, Peters, Katharina, additional, Pletz, Mathias W., additional, Ramirez, Mário, additional, Rieger, Martin, additional, Roche-Hakansson, Hazeline, additional, Rosch, Jason W., additional, Schähle, Yvonne, additional, Selva, Laura, additional, Short, Kirsty R., additional, Standish, Alistair J., additional, Swords, W. Edward, additional, Tettelin, Hervé, additional, Trappetti, Claudia, additional, Tuomanen, Elaine, additional, van der Linden, Mark, additional, Vollmer, Waldemar, additional, Zähringer, Ulrich, additional, and Zomer, Aldert, additional

Published
2015
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