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The “eshiret” (‘eşîret in the romanized Kurmanji Kurdish alphabet) is a highly variable and situated concept and social and political entity in Kurdistan, the homeland of ethnic Kurdish people. This essay is based on regular ethnographic fieldwork I have been conducting in part of Kurdistan, the Kurdistan Region of Iraq. My first research stint was in the mid-1990s, and I was there most recently in 2016. During the early period of my research, I had a great deal of contact with people in nonurban settings for whom an eshiret may be an important social category and contributor to individual identity.

Cell fate decisions are essential for tissue development and homeostasis and can be induced by chemical and mechanical inputs. While the mechanisms by which chemical signals control cell fate have been well studied, how mechanical inputs impact cell fate decisions are not well understood. Here, we use the well-defined system of keratinocyte differentiation in the skin to define mechanisms by which mechanical inputs control cell fate. Although mechanical signals are known to induce epidermal differentiation, whether and how direct force transmission to the nucleus regulates cell fate decisions remains unknown. Here, we measure tension on the nucleus through the Linker of Nucleoskeleton and Cytoskeleton (LINC) complexes using a molecular biosensor during keratinocyte differentiation. We show that undifferentiated epidermal stem cells display high tension on the LINC complex when integrins are engaged. During differentiation, tension decreases on the LINC complex and on A-type lamins, suggesting that the state of the nuclear lamina is altered during differentiation. LINC complex ablation in mice reveals that LINC complexes are required to repress epidermal differentiation in vitro and in vivo , suggesting that force transduction from engaged integrins to the nucleus plays a role in maintaining keratinocyte progenitors. This work reveals a direct mechanotransduction pathway capable of relaying adhesion-specific signals to regulate cell fate.

Adem Uzun, “Living Freedom”: The Evolution of the Kurdish Conflict in Turkey and the Efforts to Resolve it. Berghof Transitions Series No. 11. Berlin: Berghof Foundation, 2014. 48 pp., (ISBN: 978-3-941514-16-4).Ebru Sönmez, Idris-i Bidlisi: Ottoman Kurdistan and Islamic Legitimacy, Libra Kitap, Istanbul, 2012, 190 pp., (ISBN: 978-605-4326-56-3). Sabri Ateş, The Ottoman–Iranian Borderlands: Making a Boundary, 1843-1914, New York; Cambridge University Press, 2013. 366., (ISBN: 978-1107033658). Choman Hardi, Gendered Experiences of Genocide: Anfal Survivors in Kurdistan-Iraq. Farnham, Surrey and Burlington Vermont: Ashgate, 2011, xii + 217 pp., (ISBN: 978-0-7546-7715-4).Harriet Allsopp, The Kurds of Syria: Political Parties and Identity in the Middle East, London and New York, I.B. Tauris, 2014, 299 pp., (ISBN: 978-1780765631).Khanna Omarkhali (ed.), Religious Minorities in Kurdistan: Beyond the Mainstream [Studies in Oriental Religions, Volume 68], Wiesbaden: Harrassowitz, 2014, xxxviii + 423 pp., (ISBN: 978-3-447-10125-7).Anna Grabole-Çeliker, Kurdish Life in Contemporary Turkey: Migration, Gender and Ethnic Identity, London: I.B. Taurus, 2013, 299 pp., (ISBN: 978-1780760926).

In this article, we present a model of gender within patrilineal descent for a broad region covering Asia, Europe, and North Africa. We develop the concept of “lineal masculinity,” a perceived ontological essence that flows to and through men over the generations. It is especially expressed through people's notions of the past, present, and future of their patrilineages. We elaborate lineal masculinity in terms of male achievement, lineage founders, lineage segmentation, and male reproduction. Our model offers cross-cultural analysis and so provides an alternative to the position of strong cultural relativism in kinship and gender studies. [patriliny, masculinity, lineage theory, kinship, gender, identity, memory]

In this article I propose a new model of namus, the concept recognized in some circum-Mediterranean, Middle Eastern, and Central and South Asian cultures and usually translated as “honor.” One way to understand namus is to regard it as patrilineal sovereignty, particularly reproductive sovereignty. After an “honor killing,” a “defense of honor” explanatory narrative is told by both perpetrator and community alike. I argue that an honor killing represents a show of reproductive sovereignty by people who belong to a patrilineage. I first describe ethnographic contexts in which “honor killings” are operative, and then, relying on Delaney's (1991) model of namus as deeply bound up with patrogenerative theories of procreation, argue that a hymen is both a symbolic and real border to membership in the group. Finally, I apply this new conceptualization to statecraft, specifically to killings carried out in Iraqi Kurdistan following the founding of the Kurdish statelet there in 1991. Here, reproductive sovereignt...

This article examines the phenomenon of Iraqi Kurdish out-migration to the West between 1991 and 2003. It argues that migrants looked to the West and Westerners as potential patrons and were incited to migrate by their conceptualizations of patronage and clientage roles. Iraqi Kurdish migrants to the West constituted one of the largest flows of asylum-seeking clandestine migrants in the world by the late 1990s. European governments first accepted their asylum claims as "legitimate" but later accused the migrants of being a "problem" and ceased granting asylum to most applicants. This article demonstrates how participants in the Iraqi Kurdish body politic posture themselves as clients and formulate the ideal roles of patrons in the migration process based on prior experience as clients of the state tribal leaders and other figures. Patronage and clientage roles provide both an interpretive frame and a motivator for the act of migrating. (authors)

© 2005 Elsevier 0196-4399/00 (see frontmatter) 23 Strongyloides stercoralis is a parasitic nematode that causes human disease worldwide but is most prevalent in tropical and subtropical regions of the world (1). Most Strongyloides infections produce asymptomatic disease that can remain dormant in the infected host throughout life. Predisposing factors, such as immunosuppression, can result in the development of symptomatic disease leading to a disseminated hyperinfection syndrome, and possibly death. This case report describes a previously healthy person who received short-term corticosteroid therapy that resulted in the development of pulmonary strongyloidiasis with a fatal outcome.

Explorations in Anthropology and Theology. Frank A. Salamone and Walter Randolph Adams. eds. Lanham, MD: University Press of America. 1997. xii. 279 pp. $57.50 (cloth); $32.50 (paper).

Four structural analogs of benzoporphyrin derivative (BPD), a potent anti-tumor photosensitizer, were evaluated for their capacity to influence the immunologically-mediated contact hypersensitivity (CHS) response against the hapten 2,4-dinitrofluorobenzene (DNFB). Immunocompetent hairless strain mice received BPD monoacid ring A (BPD-MA, verteporfin) and returned to normal housing conditions or treated with 690 nm red light (transcutaneous photodynamic therapy, PDT). Unexpectedly, we found that mice given BPD-MA exhibited significantly reduced CHS ear swelling responses to DNFB upon antigenic challenge, whether or not they had been treated with PDT. A significant reduction in the CHS response to DNFB was observed when BPD-MA or PDT was given 48 or 24 h prior to, on the same day, or 24 or 72 h after DNFB sensitization. However, the magnitude of the CHS response was unaffected if these treatments were given 96 h after DNFB sensitization, 24 h before challenge with DNFB. Significantly reduced CHS responses also occurred in Balb/c mice given BPD-MA with or without PDT. Mice given BPD-MA but retained in total darkness throughout the experimental period generated full-fledged ear swelling responses to DNFB indicating that CHS suppression with BPD-MA was light dependent. BPD monoacid ring B (BPD-MB) strongly reduced the CHS response of Balb/c mice kept under ambient light while BPD diacid ring A (BPD-DA) and BPD diacid ring B (BPD-DB) also lowered the CHS response but were less effective than the monoacid forms. Other photosensitizers including Photofrin, tin etiopurpurin, and zinc phthalocyanine did not alter the CHS response of Balb/c mice maintained under ambient light. The ability of different BPD analogs to inhibit the CHS response in mice held under ambient light conditions appears related to the potent photosensitizing activity of these compounds.

The impact of bensoporphyrin derivative monoacid ring A, and visible light was determined for mouse splenic dendritic cells (DC), potent antigen-presenting cells (APC) of the immune system. It was discovered that sub-lethal doses of BPD-MA and light significantly altered the surface receptor pattern of DC as well as diminishing the capacity of these cells to activate allogeneic T cells. Treatment of highly purified DC with BPD-MA and 690 nm wavelength light decreased DC expression of major histocompatibility (MHC) Class I and II antigens, leukocyte common antigen CD45, intercellular adhesion molecule-1 (ICAM-1, CD54), the co- stimulatory molecules CD80 and CD86, CD95 as well as integrin CD11c. In contrast, DC expression of leukocyte function-associated-1 (LFA-1, CD11a), CD11b, CD18, CD40, and the DC DEC-205 receptor increased after the treatment. Changes in receptor levels occurred rapidly. DC MHC Class I and ICAM-1 expression declined to 40 percent of control levels by 2 hours post-PDT. DC treated with BPD-MA and light were poor stimulators of allogeneic T cells in the mixed leukocyte reaction. BPD-MA, in the absence of light, had no effect on the immunostimulatory properties of these cells. The changes in DC receptor expression pattern produced by BPD-MA and light were comparable to those produced by ultraviolet B light, a treatment known to alter the immunostimulatory characteristics of DC. Photodynamic therapy with BPD-MA represents an innovative approach for the modification of immune reactivity.© (1997) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

The rat monoclonal antibody LR-1 was initially described to be reactive with an antigen present on murine splenic B lymphocytes. However, flow-cytometric analyses of cells obtained from thymus, bone marrow, spleen, and lymph nodes showed that LR-1 stained approximately 95, 95, 60–70 and 20% of cells present within these tissues in normal DBA/2 mice. The marker recognized by LR-1 was present on peripheral erythrocytes and splenic dendritic cells, and activation with lipopolysaccharide A further increased expression of this antigen by splenic B cells. This particular tissue and cellular distribution was similar to that delineated with monoclonal antibodies reactive with heat-stable antigen (HSA). Dual-labelling studies were conducted to compare the reactivity patterns of LR-1 and the HSA-reactive monoclonal antibody J11d and indicated that both antibodies recognized splenocytes bearing B cell (IgM) or erythroid (TER-119, CD71) but not T cell (CD4, CD8) markers. Splenocytes exposed to phosphoinostol-specific phospholipase C showed marked reduction in LR-1 binding, indicating that this antibody recognized a glycosylphosphatidylinositol-anchored cell surface protein, consistent with the known structure of HSA. Mixing of LR-1 with the HSA-specific antibodies Jlld or M1/69 provided flow-cytometric profiles indistinguishable from those obtained with either antibody alone. However, LR-1 inhibited M1/69 binding to splenocytes by 83%, while J11d reduced Ml/69 binding to these cells by only 18%. This finding suggested that LR-1 and Ml/69 recognize identical splenic HSA epitopes, while LR-1 and J11d bind distinct antigenic determinants of spleen HSA. Western blot analysis of splenocyte, thymocyte, bone marrow cell and erythrocyte detergent extracts revealed that LR-1 reacted with glycoforms of HSA of known molecular weights (30–55 kD). Thus, LR-1 recognizes HSA, the murine analogue of human CD24, and will be a useful reagent with which to investigate the role of HSA in the immune response and hematopoiesis.

The proinflammatory cytokine interleukin-20 (IL-20) may exert the majority of its activity in the skin. We examined the effect of various treatments including several forms of phototherapy on IL-20 expression using cultured normal human epithelial keratinocytes (NHEK). Broadband UVB light, recombinant (r) IL-1 and rIL-8 increased, while hydrocortisone reduced, NHEK supernatant IL-20 levels. Elevation of NHEK IL-20 mRNA and maximal supernatant IL-20 levels occurred with a UVB light dose (40 mJ cm(-2)) that reduced cell viability by approximately 50%. While this UVB light dose also elevated supernatant IL-1 alpha and IL-8 levels, antibody neutralization studies indicated that neither of these cytokines was directly responsible for this increase in IL-20 expression. However, the elevation in IL-20 levels was fully inhibited by the p38 mitogen-activated protein kinase (MAPK) inhibitor SB-203580, suggesting involvement of this stress signaling pathway in this UVB light response. Photodynamic therapy (PDT) with the photosensitizer lemuteporfin, UVA light, cisplatin, lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-alpha) or recombinant interferon-gamma (rIFN-gamma) either had little effect or decreased NHEK supernatant IL-20 levels. Reduced IL-20 levels paralleled the cytotoxic actions of PDT, UVA light or cisplatin and the antiproliferative effect of rIFN-gamma. Neither rIL-20 supplementation nor anti-IL-20 antibody treatments affected cell viability indicating that soluble IL-20 did not affect the short-term survival of UVB light-irradiated NHEK. Stimulation of IL-20 expression in keratinocytes by UVB light suggests that this cytokine might participate in skin responses to this ever-present environmental factor and potentially has a role in UV light-associated dermatoses.

The original caption of this picture, which appeared in the 2000 Amnesty International wall calendar, tells us that it is of “Kurdish refugees” as they “collect wood for heating, village of Doganli, Turkish Kurdistan 1997.” While other women trudge through the snow behind her, a woman has taken a moment out of her task of burdencarrying to pose for the camera. Most likely at the behest of the photographer, she affects a needy, helpless person reaching out for assistance.