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Implementing quantum algorithms on realistic devices requires translating high-level global operations into sequences of hardware-native logic gates, a process known as quantum compiling. Physical limitations, such as constraints in connectivity and gate alphabets, often result in unacceptable implementation costs. To enable successful near-term applications, it is crucial to optimize compilation by exploiting the capabilities of existing hardware. Here we implement a resource-efficient construction for a quantum version of AND logic that can reduce the compilation overhead, enabling the execution of key quantum circuits. On a high-scalability superconducting quantum processor, we demonstrate low-depth synthesis of high-fidelity generalized Toffoli gates with up to 8 qubits and Grover’s search algorithm in a search space of up to 64 entries. Our experimental demonstration illustrates a scalable and widely applicable approach to implementing quantum algorithms, bringing more meaningful quantum applications on noisy devices within reach.

Osteosarcoma (OS) is the second most common primary malignant bone tumors in adolescents that causes cancer-related deaths. Previous studies have confirmed the promoting role of lncRNA HCP5 in the development of OS, but the specific mechanism is still not well understood. MiRNA levels were measured via RT-qPCR and protein expression was detected via western blotting. Cell proliferation was analyzed by CCK-8 assays and colony formations assay were conducted to measure colony formation ability. Dual-luciferase reporter assay was performed to detect the targeting relationship between HCP5 and miR-29b-3p, and between miR-29b-3p and LOXL2. Wound healing assays and Transwell assays were conducted to verify the migration and invasion abilities of OS cells. Correlations between the levels of HCP5 and miR-29b-3p, and between miR-29b-3p and LOXL2 were determined by Pearson correlation coefficient analysis. MiR-29b-3p expression was decreased and HCP5 and LOXL2 levels were increased in OS tissues and cell lines. MiR-29b-3p could directly act on LOXL2 and knockdown of LOXL2 restrained the proliferation, migration, and invasion of OS cells. Moreover, transfection with sh-HCP5-1 and sh-HCP5-2 suppressed the malignant biological behavior of OS cells. HCP5 directly targeted miR-29b-3p, and promoted OS proliferation, migration, and invasion via the miR-29b-3p/LOXL2 axis. The lncRNA HCP5 may upregulate LOXL2 expression by targeting miR-29b-3p, thereby promoting OS proliferation, migration, and invasion.

Scaling is now a key challenge in superconducting quantum computing. One solution is to build modular systems in which smaller-scale quantum modules are individually constructed and calibrated, and then assembled into a larger architecture. This, however, requires the development of suitable interconnects. Here, we report low-loss interconnects based on pure aluminium coaxial cables and on-chip impedance transformers featuring quality factors up to $8.1 \times 10^5$, which is comparable to the performance of our transmon qubits fabricated on single-crystal sapphire substrate. We use these interconnects to link five quantum modules with inter-module quantum state transfer and Bell state fidelities up to 99\%. To benchmark the overall performance of the processor, we create maximally-entangled, multi-qubit Greenberger-Horne-Zeilinger (GHZ) states. The generated inter-module four-qubit GHZ state exhibits 92.0\% fidelity. We also entangle up to 12 qubits in a GHZ state with $55.8 \pm 1.8\%$ fidelity, which is above the genuine multipartite entanglement threshold of 1/2. These results represent a viable modular approach for large-scale superconducting quantum processors.

Breast cancer (BC) poses a huge threat to women's health. Growing evidence has shown lncRNAs play critical roles in BC progression. However, the effect of LINC00536 in BC remains unknown. LINC00536, miR-4282, and centromere protein F (CENPF) expressions in BC cells were determined using qPCR assay. Colony formation assay was employed to evaluate the cell proliferation of BC cells. Besides, cell migration and invasion were evaluated using the transwell assay. FISH assay was employed to analyze LINC00536 and miR-4282 locations in BC cells. Additionally, dual luciferase reporter gene assay was performed to verify the binding relationships between LINC00536 and miR-4282, miR-4282 and CENPF. Here, our results displayed that LINC00536 and CENPF were overexpressed in BC cells, while miR-4282 was downregulated. LINC00536 could negatively regulate miR-4282 expression via directly binding to miR-4282. LINC00536 silence suppressed the proliferation, migration, and invasion of BC cells, which was abolished by miR-4282 inhibition. Additionally, miR-4282 could negatively regulate CENPF expression via directly binding to CENPF. MiR-4282 overexpression suppressed BC development, which was abolished by CENPF overexpression. Finally, we proved that LINC00536 silencing suppressed BC growth via regulating the miR-4282/CENPF axis in vivo. Our research displayed that LINC00536 acted as an oncogene in BC. LINC00536-enhanced BC cell proliferation, migration, and invasion. Moreover, LINC00536 functioned as a ceRNA to exert malignant characteristics in BC via the miR-4282-CENPF axis. Collectively, our results demonstrated that the LINC00536-miR-4282-CENPF axis was a critical player in BC development and was a promising target for BC therapy.

Weyl semimetals have drawn considerable attention for their exotic topological properties in many research fields. When in combination with s-wave superconductors, the supercurrent can be carried by their topological surface channels, forming junctions mimicking the behavior of Majorana bound states. Here, we present a transmon-like superconducting quantum intereference device (SQUID) consisting of lateral junctions made of Weyl semimetal Td-MoTe2 and superconducting leads of niobium nitride (NbN). The SQUID is coupled to a readout cavity made of molybdenum rhenium (MoRe), whose response at high power reveals the existence of the constituting Josephson junctions (JJs). The loop geometry of the circuit allows the resonant frequency of the readout cavity to be tuned by the magnetic flux. We demonstrate a JJ made of MoTe2 and a flux-tunable transmon-like circuit based on Weyl semimetals. Our study provides a platform to utilize topological materials in SQUID-based quantum circuits for potential applications in quantum information processing.

To achieve cleaner production in palm oil mills (POM), eliminating palm oil mill effluent (POME) via evaporation provides promising benefits towards palm oil sustainability. The incorporation of POME evaporation creates circular economy opportunities between mill, refinery and cogeneration system via converting mill-refinery effluent to oil recovered-solids and regenerated water, broadening biomass-to-energy potential to support energy-extensive evaporation and water integrations. Such industrial symbiosis scheme named as the integrated palm oil-based complex (POBC) could consider participation from different companies to provide desired processing facilities in achieving the optimal performance of POBC. For the new POBC scheme, the individual interest for each participating facility is hard to define due to the lack of basis for profit distribution. It is crucial to propose an optimal business model for POBC planning to demonstrate the financial allocation among possible partners based on the pooled incremental gains in the POBC coalition. The business model serves as a tool to persuade the companies in collaborating by quantifying their potential economic benefits and contributions for negotiation before forming the POBC. The cooperative game theory model has been useful in distributing cost savings within a coalition of individual plants. On that account, an integrated cooperative game-based optimisation approach is proposed to optimally distribute the profit gain and investment sharing between POM, palm oil refinery and biomass-cogeneration system to develop a feasible business model for a multi-owner POBC. Seven scenarios have been evaluated to generate optimal multi-owner POBC business models achieving 7-13 % improvements in economic potential. The average economic allocations of collaborating POM, refinery and cogeneration system are 91.8 %, 2.4 % and 5.8 % in the multi-owner POBCs.

Palm oil mill effluent (POME) is recognised as one of the biggest sources of pollution due to its eutrophying nature and methane emitting treatment. Although biogas recovery and utilisation are promoted through government initiatives, the motivation and support from mills still reported low in Malaysia. This paper aims to discuss the benefits and drawbacks of POME utilisation in the palm oil supply chain based on environmental, social and economic concerns to review the favourability of POME elimination. A zero effluent approach is introduced based on POME evaporation technique, undiluted clarification practice and water recycling strategy as an alternative for conventional POME management approaches. An integrated palm oil complex concept is proposed which includes new palm oil processing approach that eliminates POME and provides industrial symbiosis possibilities within palm oil upstream and downstream sectors to promote sustainability of palm oil industry with balanced economic and environmental advantages. A comparative study between POME utilisation (Case 1 and 2) and POME elimination (Case 3) in different perspectives is included in this work. In the economic view, the payback period of Case 3 is shorter (4 y) compared to Case 1 and 2 (4.3–8.3 y). In comparison, POME elimination technology is more environmentally friendly due to smaller water and land footprint, zero methane emission and minimum waste generation. Approximately 0.3% improvement in oil extraction rate can be potentially achieved by the proposed mill configuration in Case 3. One of the challenges in POME elimination implementation is the additional 0.25 kg steam requirement associated with evaporation of 1 kg water. The study provides insights on the feasibility of the proposed sustainable concept in Malaysia with consideration of government policies and programmes. The suggested POME elimination-based complex provides alternative option to mill owners who are uninterested to invest in biogas capturing facilities.

Weyl semimetals have drawn considerable attention for their exotic topological properties in many research fields. When in combination with s-wave superconductors, the supercurrent can be carried by their topological surface channels, forming junctions mimicking the behavior of Majorana bound states. Here, we present a transmon-like superconducting quantum intereference device (SQUID) consisting of lateral junctions made of Weyl semimetal Td-MoTe

Recent threats to sustainability in the palm oil milling industry such as methane emissions, has impacted the palm oil market negatively. To facilitate methane emission mitigation, most palm oil mills opt for expensive biogas facilities. An alternative solution to this expensive biogas facility, can be an integrated palm oil-based complex (POBC). POBC is proposed to reduce environmental consequences while maximising the palm oil mill profit by integrating it with a palm oil refinery and implementing POME elimination strategy. However, in order to understand the feasibility of the POBC, it is important to identify the most crucial process otherwise known as the anchor process. The anchor process can be determined based on the allocation of incremental economic benefits among the internal processes. On that account, in work proposes a new process-level performance allocation approach based on cooperative game theory to investigate future optimisation strategies for the POBC. Cooperative game theory was previously applied for rationally allocating incremental profits among collaborating parties and determining anchor tenant within an eco-industrial park. In this study, the cooperative game model analyses internal processes instead of collaborating plants to determine the anchor process. The anchor process is critical for defining performance benchmarks for other processes within the POBC. The developed framework is applied consecutively on the given POBC case study based on the presented framework. The optimal results obtained are analysed to determine the anchor process for deciding suitable strategies to improve the overall profitability of POBC.

The challenge in clean palm oil production falls on the management of palm oil mill effluent which is a notable source of greenhouse gas emissions and water pollution. To address these critics against edible palm oil, an integrated palm oil-based complex (POBC) considering effluent elimination and refinery integration is suitable for environmental-food-energy-water (EFEW) nexus development. Optimal retrofit of palm oil mill into EFEW nexus-integrated POBC requires multi-objective considerations to balance the trade-offs between profitability, energy contribution, greenhouse gas, water and land footprints via fuzzy optimisation. With limited practical knowledge, potential flowsheet modifications should be investigated for flexible POBC design. In a cooperative game context, interconnecting processes act as multiple players cooperating to achieve the goal of the game, i.e., POBC performance, where each player has a distinctive impact on the outcome. In this work, such process performance was suggested to be distributed using cooperative game model, to target the EFEW-based anchor process, i.e., the process stage of greatest contribution in the weighted EFEW nexus, for desired flowsheet advancement. Considering these aspects, an integrated fuzzy and cooperative game optimisation framework was developed to identify the anchor process of an EFEW nexus-integrated POBC. EFEW objective-based process performance allocation in the fuzzy optimal POBC was weighted by the decision-maker to allocate the anchor process using developed models and Excel tools. Nut/kernel separation and cogeneration stage is the EFEW-based anchor process in the fuzzy optimal POBC with EFEW nexus score of 41% in this work. A comparative analysis between the proposed method with other approach was done. The favourability of EFEW contributions by POBC in terms of benefit-drawback ratio increased with the percentage of boiler efficiency increment within the targeted anchor process. Targeting anchor process aids planning for process maintenance and advancement to avoid resource wastage on sub-critical processes.

Palm oil mill effluent (POME) is one of the biggest pollution sources due to its eutrophying nature and methane emitting treatment technology. Although biogas capture and utilisation have been widely encouraged to achieve greenhouse gas (GHG) mitigation in palm oil mills (POM), most Malaysian POMs still find it economically infeasible to invest in proper biogas facilities. Hence, POME elimination should be considered as one of the waste management options in synthesising palm oil processing pathway for profit enhancement and GHG mitigation. One of the solutions to achieve sustainability in palm oil industry is to integrate POM and palm oil refinery (POR) in terms of waste management, energy and resource. Therefore, it is desired to design an optimally integrated palm oil based-complex (POBC) which considers POME evaporation approach. The main objective of this study is to develop a model to aid POBC planning via synthesis of an integrated resource and utility network considering POME elimination with maximum profit. Based on the case study, maximum USD 36.65 x 106 is obtained for the optimal POBC design with POME elimination pathway selected. The optimum production rate for Refined, Bleached, Deodorised Palm Olein (RBDPOL) is 10.309 t/h which is boosted compared to the baseline study. 61 % less water demand is also achieved. The research output, the developed model and optimal network shall provide input to POM owners on optimal POME management and determine the economic feasibility of proposed POBC in Malaysia.

Palm oil mill effluent (POME) elimination has been considered recently as the alternative to expensive biogas recovery to conquer environmental criticisms in the palm oil industry involving the release of biogas (i.e., a primary contributor towards climate change), during POME treatment. With POME elimination and mill-refinery integration considered, the integrated palm oil-based complex (POBC) serves as an appropriate system for sustainable food-energy-water (FEW) nexus evaluations. In this respect, multi-objective optimisation and debottlenecking of POBC has been suggested to address the economic and environmental trade-offs in palm oil mill (POM) for cleaner production. In this study, a stepwise debottlenecking framework was proposed to include previous fuzzy multi-objective optimisation approach and a new debottlenecking method to improve the fuzzy optimal POBC design and evaluate the impact of process on FEW nexus contributions. Each process creates distinctive impact or influence on the POBC performance. Shapley-Shubik Power Index (SSI) has been applied in the notion of power for yes-no voting systems. By evaluating the operate-fail possibilities of internal processes, SSI can be utilised to allocate the power of each process in achieving or failing the POBC performance target, prior to identifying the system bottleneck (SB) in terms of process stage. Therefore, a novel process-level debottlenecking approach with SSI incorporation for a sustainable FEW system was proposed. The SB of greatest impact on overall POBC performance within the fuzzy optimal flowsheet was identified based on SSI allocation and weightage assignment considering decision-maker's interest in multiple goals. Subsequently, the debottlenecked POBC flowsheet with improvement in SB process parameter was generated subjected to profit maximisation and environmental constraints. In this study, the nut/kernel separation and biomass cogeneration system was identified as the SB of fuzzy optimal POBC. The debottlenecked results show 0.8% and 51% of profit and net energy improvement upon 30% increment of boiler efficiency. The debottlenecked flowsheet is validated in the benefit-to-drawback ratio analysis with a feasible score of 3.9. The POME-eliminated POBC generated via the integrated multi-objective optimisation and debottlenecking framework is applicable for POM retrofit to secure 13%, 97% and 47% of improvements in terms of economic potential, greenhouse gas emissions and water footprint compared to the status quo biogas utilisation scenario. The results of the study could aid palm oil holders in real-life planning of budget distribution and maintenance schedule for process stages in the retrofitted POM.

Summary In mammalian cells, histone deacetylase (HDAC) and Sirtuin (SIRT) are two families responsible for removing acetyl groups from acetylated proteins. Here, we describe protein deacetylation coupled with deacetylimination as a function of lysyl oxidase (LOX) family members. LOX-like 3 (Loxl3) associates with Stat3 in the nucleus to deacetylate and deacetyliminate Stat3 on multiple acetyl-lysine sites. Surprisingly, Loxl3 N-terminal scavenger receptor cysteine-rich (SRCR) repeats, rather than the C-terminal oxidase catalytic domain, represent the major deacetylase/deacetyliminase activity. Loxl3-mediated deacetylation/deacetylimination disrupts Stat3 dimerization, abolishes Stat3 transcription activity, and restricts cell proliferation. In Loxl3 −/− mice, Stat3 is constitutively acetylated and naive CD4 + T cells are potentiated in Th17/Treg cell differentiation. When overexpressed, the SRCR repeats from other LOX family members can catalyze protein deacetylation/deacetylimination. Thus, our findings delineate a hitherto-unknown mechanism of protein deacetylation and deacetylimination catalyzed by lysyl oxidases.

LIF promotes self-renewal of mouse embryonic stem cells (mESCs), and in its absence, the cells differentiate. LIF binds to the LIF receptor (LIFR) and activates the JAK-STAT3 pathway, but it remains unknown how the receptor complex triggers differentiation or self-renewal. Here, we report that the LIFR cytoplasmic domain contains a self-renewal domain within the juxtamembrane region and a differentiation domain within the C-terminal region. The differentiation domain contains four SPXX repeats that are phosphorylated by MAPK to restrict STAT3 activation; the self-renewal domain is characterized by a 3K motif that is acetylated by p300. In mESCs, acetyl-LIFR undergoes homodimerization, leading to STAT3 hypo- or hyper-activation depending on the presence or absence of gp130. LIFR-activated STAT3 restricts differentiation via cytokine induction. Thus, LIFR acetylation and serine phosphorylation differentially promote stem cell self-renewal and differentiation.

To reduce greenhouse gas (GHG) impact while sustaining palm oil mill (POM) profitability, Malaysia has recognised POME-derived biogas as a renewable energy. Biogas utilisation for on-site fuel replacement and grid electricity contribution is encouraged by government schemes such as Feed-in-tariff (FiT). Nevertheless, adoption rate of biogas facility is still low among Malaysian POMs. An integrated palm-oil based complex (POBC) was proposed for GHG mitigation by integrating POM and refinery processes while addressing sustainability concerns. This study presented a multi-objective optimisation model-based approach to aid POBC planning at maximised economic potential and net energy, while minimising its GHG emission, water footprint (WFP) and land footprint (LFP) for environment protection. Trade-offs between biogas recovery and POME elimination strategies were considered. The developed fuzzy model was applied to case study and analysed under different multi-objective scenarios. In comparison with baseline study, the economic potential of sustainable POBC increase by 6.7% at USD 39.31 × 106 with 88%, 74% and 91% improvements in GHG footprint, WFP and LFP by compromising 76% net energy. Effect of FiT revenue towards POBC synthesis was investigated. Pareto front was generated to verify the fuzzy results and visualise the relationship between objective functions. The optimisation model and optimal results shall provide input to Malaysian POMs on the sustainability benefits of POBC.

Understanding transport properties in quantum nanophotonics plays a central role in designing few-photon devices, yet it suffers from a longstanding extensive computational burden. In this work, we propose a statistically driven model with a tremendously eased computational burden, which is based on the deep understanding of the few-photon spontaneous emission process. By utilizing phenomenological, statistically driven inter-photon offset parameters, the proposed model expedites the transport calculation with a three-order-of-magnitude enhancement of speed in contrast to conventional numerical approaches. We showcase the two-photon transport computation benchmarked by the rigorous analytical approach. Our work provides an efficient tool for designing few-photon nano-devices, and it significantly deepens the understanding of correlated quantum many-body physics.

Der Einsatz neuer Techniken macht neue Formen des individuellen und organisationalen Lernens moglich. Dies fuhrt jedoch nicht automatisch zum Erfolg fur Menschen und Unternehmen. Der Einsatz neuer Techniken ist nur dann erfolgversprechend, wenn er um neue Formen der Organisationsentwicklung und neue Verhaltensweisen erganzt wird. Das Lernen ist einem Wandel unterworfen, es ist nicht mehr nur auf Vorrat moglich, sondern kann mit Technikunterstutzung anforderungsbezogen und selbstandig durchgefuhrt werden. Ort und Zeitpunkt werden dabei vom Lernenden gewahlt. Eine haufige Form des beruflichen Lernens, der seminarbasierte Unterricht wird um weitere Formen digitalen Lernens erganzt. Eine Vernetzung der Lernenden unterstutzt das gruppenweite Lernen. Dieses fordert den Informationsaustausch untereinander und den Aufbau von organisationalen Wissensbestanden, die fur alle zuganglich sind. Bei unserem Arbeiten gingen wir von der Hypothese aus, dass digitale Kooperationsplattformen ortlich verteilte Teammitglieder bei der Organisation ihrer Wissensarbeit unterstutzen und zum Aufbau einer organisationalen Wissensbasis fuhren werden.

Die Virtualisierung von Organisationsstrukturen stellte viele Organisationen in den letzten Jahren vor neue Fragen. Die Debatte zur Globalisierung zeigt, dass sich Wertschopfungsketten von ihrer Ortsbindung befreien und uberregional stattfinden. Unternehmen reagieren durch Dezentralisierung und Starkung der Autonomie ihrer lokalen organisatorischen Zellen. Virtualisierung wird zur „Vision“ (Moslein 2001; Lotter, Sommer 2001).

Im Rahmen des vom BMBF geforderten Projektes WInn (Wissensgenese und -Verteilung als Innovationsmotor, BMBF-Projekt Kz. 0415051) untersuchten wir, wie technische Systeme zur Unterstutzung von interorganisationaler Zusammenarbeit genutzt werden. Unsere Analyse konzentrierte sich auf die Nutzung des BSCW Shared Workspace Systems.