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Kolesterol adalah masalah kompleks bagi manusia pada saat kadar LDL lebih mendominasi menyebabkan penyakit jantung dan hipertensi akibat dari terjadinya aterosklerosis. Prevalensi di Amerika Serikat orang dewasa mengalami peningkatan kadar kolesterol >12%. Kalimantan Tengah data penderita kolesterol mencapai 54,2%. Kolesterol 2/3 diproduksi oleh hati sedangkan 1/3 nya diserap oleh sistem pencernaan dari makanan yang dikonsumsi. Kopi tidak mengandung kolesterol namun kopi mengandung kafestol dan kahwoel yang dapat larut dalam lemak sering disebut dengan diterpenes. Tujuan dari review tinjauan ini adalah mengetahui pengaruh kopi terhadap peningkatan kadar kolesterol. Penelitian ini menggunakan pendekatan systematic review dengan kata kunci kopi, kadar kolesterol, pengaruh konsumsi kopi, dengan metode PRISMA. Dari hasil pencarian, diperoleh 14 jurnal membahas tentang pengaruh konsumsi kopi terhadap kadar kolesterol dan berapa jumlah konsumsi kopi yang dapat mempengaruhi kadar kolesterol serta pengaruh konsumsi kopi terhadap kadar LDL. Sebanyak 12 jurnal (85,2%) menyatakan terdapat pengaruh yang signifikan sedangkan 2 jurnal (14,2%) menyatakan tidak ada pengaruh yang signifikan. Adapun dari hasil tinjauan literature, dapat disimpulkan bahwa terdapat pengaruh konsumsi kopi terhadap kadar kolesterol, jumlah konsumsi kopi yang dapat mempengaruhi kadar kolesterol dan pengaruh kopi terhadap kadar LDL

Background: Kelakai (Stenochlaena palustris) is a local vegetable of the Dayak tribe that contains Vitamin C, and the majority is cooked by boiling. Research Objectives: The aim of this study was to determine the effect of the boiling method on vitamin C levels in the kelakai plant. Method: This research was an experimental study to test vitamin C on samples of fresh kelakai, boiled kelakai (3 minutes), and positive control using UV-Vis Spectrophotometry qualitatively and quantitatively. The results were then statistically tested. Results: The vitamin C content of fresh kelakai was 0.001704 mg/g, boiled kelakai for 3 minutes was 0.000846 mg/g, and the positive control was 0.006840 mg/g. The statistical Kruskal-Wallis test and post-hoc Mann-Whitney test showed that there were very significant differences in vitamin C levels in samples of fresh kelakai, boiled kelakai, and positive control (p =0,001). Conclusions: According to the results of statistical tests, there are differences in vitamin C levels in samples of fresh kelakai, boiled kelakai, and positive control.

Latar Belakang Masalah : Kesehatan anak menjadi perhatian penting bagi dunia dan di Indonesia khususnya Kalimantan Tengah. Hal ini berdasarkan data Riskesdas tahun 2018 bahwa Kalteng menjadi provinsi urutan ke-15 dalam proporsi status gizi buruk dan gizi kurang balita, urutan ke 5 dalam proporsi status gizi sangan pendek dan pendek, dan menjadi provinsi urutan ke 4 dalam proporsi status gizi kurus dan sangat kurus pada balita. data Riskesdas status gizi remaja perempuan di provinsi Kalimantan Tengah tahun 2017 indeks TB/U persentase pendek sebesar 36,8% dan sangat pendek sebesar 10,5%. Sarana kesehatan yang berada di wilayah Desa Tumbang Rungan dapat dikatakan kurang memadai, baik dalam kuantitas maupun kualitas. Berdasarkan latar belakang tersebut peneliti ingin melakukan pemeriksaan status kesehatan dan status gizi anak-anak di desa Tumbang Rungan. Metode Penelitian : penelitian deskriptif observasional secara cross sectional. Sampel diambil dengan purposive sampling siswa SD Tumbang Rungan dan SMP Satu Atap Tumbang Rungan. data penelitian meliputi data karakteristik responden, pemeriksaan antropometri (tinggi badan, berat badan), dan pemeriksaan fisik (tekanan darah, rambut, gigi mulut, mata, telinga, kulit, jantung, paru). Hasil: subyek penelitian sebanyak 20 orang mengalami 55% status gizi kurang dan buruk (BB/U), 55% stunting (TB/U), 20% sangat kurus (IMT/U). Kesehatan organ kulit, rambut, kuku dan gigi masih masuk dalam keadaan tidak sehat. Kesimpulan : Masalah kesehatan gizi pada anak dan remaja di kelurahan Tumbang Rungan menjadi problem utama.

There is a considerable danger of mental exhaustion or burnout for nurses who are on the front lines of treating COVID-19, which could have a long-term negative impact on the standard of medical care. The research objective was to determine nurse burnout and prove the correlation between excessive working hours and nurse burnout during the COVID-19 pandemic. The method used is a quantitative descriptive study method with a cross-sectional design. The sample in this study was all nurses at Palangka Raya Regional Public Hospital, with a total sampling of 43 nurses. The research instrument was adopted from the Maslach Burnout Inventory (MBI). The correlation test used was Cramer's V, with the significance level of the variable test stated at p

Latar Belakang : Menurut WHO sepertiga dari 25 juta kematian di seluruh dunia disebabkan oleh penyakit infeksi. Salah satu bakteri yang paling sering menyebabkan infeksi adalah Staphylococcus aureus. Tanaman herbal bawang dayak (Eleutherine palmifolia L) mengandung senyawa yang berkhasiat sebagai antibakteri, salah satunya adalah bakteri Staphylococcus aureus. Tujuan: menganalisis efektifitas bawang dayak (Eleutherine palmifolia L) dalam menghambat pertumbuhan bakteri Staphyloccus aureus. Metode: Penelitian ini adalah penelitian kepustakaan dengan sampell penelitian berupa jurnal nasional yang diperoleh 10 dari Google Cendikia, Garuda sedangkan jurnal internasional diperoleh 5 dari Google Scholar dan Science Direct. Hasil: Jurnal yang membahas mengenai efektifitas bawang dayak (Eleutherine palmifolia L) dalam menghambat pertumbuhan bakteri Staphylococcus aureus, ditemukan 15 jurnal yang menyatakan bahwa umbi bawang dayak (Eleutherine palmifolia L.) memiliki kemampuan untuk menghambat pertumbuhan bakteri Staphylococcus aureus. Pada jurnal yang diteliti juga membahas mengenai faktor yang berpengaruh terhadap efektifitas bawang dayak (Eleutherine palmifolia L) dalam menghambat pertumbuhan bakteri diantaranya adalah suhu dan lama penyimpanan ekstrak. Kesimpulan: bawang dayak (Eleutherine palmifolia L) memiliki efektifitas dalam menghambat pertumbuhan bakteri Staphylococcus aureus.

In general, the social interactions of children with autism are closely related to how the children with the disorder communicate. Failure to developing social interaction makes children with autism unable to make eye contact with their interlocutors, tend to isolate themselves from social interaction, therefore it is very necessary to minimize difficulties, obstacles/weaknesses so that children with autism can carry out social interactions. Squishy is a toy that has pores like a sponge, has a soft texture, dan elastic, it also has the ability to return to its original form. Annaliese Griffin, A New York writer claimed that Squishy could be used as a medium to developing motor skills, and through Squishy’s soft texture, it also could be used to developing children's sense of touch. Children with autism can communicate with themself, creating an imaginary friend, or inviting their parents to participate doing role-playing together, it also could be a place for to children carry out social interaction because they play with their friends. The purpose of The Study is to understand the communication skills of children with autism development after given them Squishy Toys. The research design used in this study is a quasi-experimental study that aims to identify the effect of playing squishy therapy on improving communication development in autistic children with a one-group pre-post test design approach, namely using one group of research subjects with pre-and post-treatment observations. Giving Squishy Toys has a positive impact on the development of communication skills for children with autism. This is because based on the previous study and after being given the Squishy toys treatment, it has a significant relationship.

Background: Pediculosis capitis is a scalp or hair infection in humans caused by Pediculus humanus capitis. The disease primarily affects childern and rapidly expanding in dense living environments, such as dormitories and orphanages. The purpose of this research is to know the relationship between level of knowledge and shampoo usage behavior on the incidence of pediculosis capitis in X Palangka Raya Orphanage. Method: This research was used a cross sectional approach, conducted in September 2019. Sampling techniques are performed with purposive sampling techniques. The variables studied are the level of knowledge and shampoo usage behavior. Relationship of each variable to the incidence of pediculosis capitis is measured using bivariate analysis. Research results: Based on the results of physical examination and microscopic examination was found 31 respondents (88.6%) positive of pediculosis capitis, which is based on the Chi-square test, the level of knowledge with the incidence of pediculosis capitis has p value= 0.285, and shampoo usage behavior with the incidence of pediculosis capitis has p value= 0.274. Conclusion: There is no correlation between level of knowledge and shampoo usage behavior with the incidence of pediculosis capitis in X Palangka Raya Orphanage

People in Central Borneo which is often used to treat diarrhea is the fruit of masisin (Rhodomyrtus tomentosa Wight) with active compounds which are capable to treat diarrhea such as alkaloids, flavonoids, tannins, saponins, and steroids. Diarrhea is a defecate with a liquid or half-liquid feces, the content of water in a feces is more than usual, it is more than 200 g or 200 ml / 24 hours. To know the effectiveness of the extract of the fruit of masisin as an alternative to antidiarrheal treatment seen from the frequency, duration, and consistency of feces in male white mice (Mus musculus). This study design was a true experimental design with post-test control group design with 5 treatments for each group. This study started by making some extracts of Masisin fruit. Followed observation with 5 treatment groups animals. The induction of diarrhea was using oleum ricini, with aquadest as the negative control, and Loperamide HCL as the positive control. The dose of ethanol extracts of masisin fruit divided into 0.3 mg/g BW, 0.6 mg/g BW and 1.2 mg/g BW, all of the treatments were given orally. This study data was statistically analyzed with one way ANOVA. The results of one way ANOVA test showed that the value of p

The present study was undertaken to investigate the protective effect of ethanolic citronella grass (C. nardus) leaves extract against mercury (Hg) induced glucose metabolism alteration in rats. Four groups of rats were selected, with 6 rats for each group. Animals of group I was received a 1 ppm of Hg only. Animals of groups II, III, and IV received a combination of 1 ppm Hg and plant extract in different dose (1650, 2520, and 3360 mg/ml). The experiment lasted for 4 weeks. The various parameters studied included liver weight, liver glucose, glycogen, and malondialdehyde (MDA) level in all groups after treatment. The results of this present studies showed that the Hg-induced glucose metabolism alteration in rats which can be seen from the increase of liver glucose and the decreasing of liver glycogen levels. The results also showed that the Hginduced glucose metabolism alteration through its activities in the trigger the liver cells damage which can be seen from the decreasing of liver weight and the increase of liver MDA level. The ethanolic of C. nardus leaves extract shows a protective effect to maintain all parameters into a better a condition which can be seen from the significant increase in liver weight and liver glycogen level, and the significant decrease in liver glucose and MDA levels. The present study indicated that the ethanolic C. nardus leaves extract showed a potential protective effect on glucose metabolism alteration induced by Hg

Stres oksidatif merupakan suatu kondisi ketidakseimbangan antara produksi radikal bebas dengan antioksidan dimana kadar radikal bebas lebih tinggi dibandingkan antioksidan. Di dalam tubuh, radikal bebas bersifat toksik dan dapat menimbulkan kerusakan sel. Senyawa yang memiliki aktivitas antioksidan diperlukan untuk menangkal radikal bebas. Kulit batang laban (Vitex pinnata Linn) mengandung flavonoid dan berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk membuktikan potensi antioksidan kulit batang laban dalam menurunkan kadar malondialdehida (MDA) dan meningkatkan aktivitas superoksida dismutase (SOD). Metode penelitian sebagai berikut tikus wistar dibagi menjadi 5 kelompok antara lain kelompok normal, kelompok negatif (DMBA 20mg/kg BB), kelompok uji I (DMBA 20mg/kg BB dan ekstrak kulit batang laban 150mg/kg BB), kelompok uji II (DMBA 20 mg/kg BB dan ekstrak kulit batang laban 300mg/kg BB), kelompok uji III (DMBA 20mg/kg BB dan ekstrak kulit batang laban 600mg/kg BB). Pengukuran kadar MDA serum dan aktivitas SOD dilakukan setelah 30 hari pemberian perlakuan. Hasil yang diperoleh ekstrak kulit batang laban dosis 150mg/kg BB, 300mg/kg BB dan 600mg/kg BB secara signifikan dapat menurunkan kadar MDA sebesar 13,30%, 21,26%, 29,53%. Ekstrak kulit batang laban dosis 150mg/kg BB, 300mg/kg BB dan 600mg/kg BB secara signifikan dapat meningkatkan aktivitas SOD sebesar 64%, 72,31%, 77,50%. Hal ini menunjukkan ekstrak kulit batang laban memiliki aktivitas sebagai antioksidan karena mengandung senyawa flavonoid yang dapat mendonorkan atom hidrogen ke radikal bebas yang bersifat reaktif karena memiliki satu elektron tidak berpasangan sehingga mengurangi pembentukan radikal bebas seperti MDA dan meningkatkan aktivitas SOD. Kata kunci: Vitex pinnata, superoksida dismutase, malondialdehida, antioksidan, DMBA ABSTRACT Oxidative stress is a condition of an imbalance between the production of free radicals and demand of antioxidant. Free radicals are toxic and can cause cell damage. Antioxidant are compounds that can scavenging free radicals. Vitex pinnata Linn contain flavonoid compounds as antioxidant. The objective of research is proved antioxidant activity of Vitex pinnata Linn in decrease malondialdehyde (MDA) and increase activity of superoxide dismutase (SOD). The method as follows: Wistar rats were divided into 5 groups including normal group, negative group (DMBA dose of 20mg/kg body weight), group I test (DMBA dose of 20mg/kg body weight and extract Vitex pinnata dose of 150mg/kg body weight), group II test (DMBA dose of 20mg/kg body weight and extract Vitex pinnata dose of 300mg/kg body weight), group III test (DMBA dose of 20mg/kg body weight and extract Vitex pinnata dose of 600mg/kg body weight). The results obtained extract Vitex pinnata dose of 150mg/kg body weight, 300mg/kg body weight, 600mg/kg body weight significantly decreased MDA levels by 13,30%, 21,26%, 29,53%. Extract Vitex pinnata dose of 150mg/kg body weight, 300mg/kg body weight, 600mg/kg body weight significantly increased SOD activity by 64%, 72,31%, 77,50%. This shows that extract Vitex pinnata has an antioxidant activity because contain flavonoid compounds that can donate hydrogen atoms to free radicals which have one unpaired electron thus decreasing the production of MDA and increasing SOD activity. K eywords : Vitex pinnata, superoxide dismutase, malondialdehyde, antioxidant, DMBA

Penyakit kardiovaskuler menjadi masalah kesehatan di dunia dan di Indonesia. Aterosklerosis diramalkan tahun 2020 merupakan penyebab utama morbiditas dan mortalitas di masyarakat. Radikal bebas mampu secara langsung dan tidak langsung menginduksi stress oksidatif didalam tubuh. Radikal bebas dapat menyerang asam lemak tak jenuh ganda (PUFA) , yang akan terputus menjadi sederhana sala satunya malonyldealdehide (MDA) . AOPP ( Advanced Oxidation Protein Product) berasal sebagai akibat dari tindakan radikal bebas pada protein dan sebagai mediator inflamasi. Masalah penelitian adalah apakah ada pengaruh lama paparan asap terhadap risiko aterosklerosismelalui pengukuran MDA dan AOPP secara invivo. Mengetahui pengaruh lama paparan asap terhadap risiko aterosklerosis melalui pengukuran MDA dan AOPP secara invivo. Jenis penelitian ini yakni penelitian true experimental dengan menggunakan post-test only control group design. Populasi penelitian ini adalah tikus Rattus Novergicus jantan, strain wistar dengan umur 11-12 minggu dengan berat badan ±200-210 gram, sedangkan pengambilan sampel ditetapkan berdasarkan kriteria inklusi dan eksklusi. Variabel penelitian adalah lama paparan 7 jam, lama paparan 9 jam, MDA, dan AOPP. Instrumen yang digunakan dalam penelitian ini adalah pemeriksaan laboratorium pada MDA dan AOPP. Pada analisis deskriptif, variabel MDA didapatkan rerata kelompok kontrol (0,239±0,003), kelompok paparan 7 jam (0,241±0,005), dan kelompok paparan 9 jam (0,258±0,000). Pada variabel AOPP didapatkan rerata kelompok kontrol (15,207±3,222), kelompok paparan 7 jam (37,546±10,528), dan kelompok paparan 9 jam (59,573±14,929). Uji normalitas data menunjukkan data berdistribusi normal ( p-value MDA (0,076) dan AOPP (0,346 )), uji homogenitas menunjukkan data tidak homogen ( p-value MDA (0,001) dan AOPP (0,004 )). Tidak ada pengaruh kadar MDA antara kelompok kontrol ( p-value= 0,292) dengan kelompok paparan 7 jam, ada pengaruh kadar MDA antara kelompok kontrol ( p-value= 0,0001) dengan kelompok paparan 9 jam, ada pengaruh kadar MDA antara kelompok paparan 7 jam ( p-value= 0,0001) dengan kelompok paparan 9 jam, ada pengaruh kadar AOPP antara kelompok kontrol ( p-value= 0,0001) dengan kelompok paparan 7 jam, ada pengaruh kadar AOPP antara kelompok kontrol ( p-value= 0,0001) dengan kelompok paparan 9 jam, ada pengaruh kadar AOPP antara kelompok paparan 7 jam ( p-value= 0,0001) dengan kelompok paparan 9 jam. Tidak ada pengaruh kadar MDA kelompok kontrol dengan kelompok paparan 7 jam. ada pengaruh kadar MDA kelompok kontrol dengan kelopok paparan 9 jam, antara kelompok paparan 7 jam dan 9 jam, kadar AOPP kelompok kontrol dengan paparan 7 jam, kelompok kontrol dengan paparan 9 jam, dan antara kelompok paparan 7 jam dan 9 jam. Mempertimbangkan hasil penelitian, MDA merupakan senyawa yang dapat menggambarkan aktivitas radikal bebas di dalam sel, dan AOPP merupakan produk kerusakan oksidatif pada protein, sebagai salah satu petunjuk terjadinya stress oksidatif radikal bebas.