119,088 results on '"Diamond AS"'
Search Results
2. Confirmation of four hot Jupiters detected by TESS using follow-up spectroscopy from MaHPS at Wendelstein together with NEID and TRES
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Ehrhardt, Juliana, Thomas, Luis, Kellermann, Hanna, Freitag, Christine, Grupp, Frank, Yee, Samuel W., Winn, Joshua N., Hartman, Joel D., Collins, Karen A., Watkins, Cristilyn N., Stassun, Keivan G., Benni, Paul, Bieryla, Allyson, Carden, Kylee, Checinski, Jacek, Cheryasov, Dmitry V., Diamond, Brendan, Dowling, Nicholas, Dressing, Courtney D., Esparza-Borges, Emma, Evans, Phil, Forés-Toribio, Raquel, Fukui, Akihiko, Giacalone, Steven, Girardin, Eric, Goeke, Robert F., Goessl, Claus, Hayashi, Yuya, Hopp, Ulrich, Jenkins, Jon M., Khan, Isa, Laloum, Didier, Lark, Adam, Latham, David W., de Leon, Jerome, Marchini, Alessandro, Massey, Bob, Munoz, Jose A., Murgas, Felipe, Narita, Norio, Palle, Enric, Papini, Riccardo, Parviainen, Hannu, Pippert, Jan-Niklas, Popowicz, Adam, Pritchard, Tyler, Quinn, Samuel N., Raetz, Manfred, Ries, Christoph, Riffeser, Arno, Savel, Arjun B., Seager, Sara, Schmidt, Michael, Striegel, Stephanie, Srdoc, Gregor, Stockdale, Chris, Verna, Gaia, Watanabe, David, Ziegler, Carl, and Zöller, Raphael
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report the confirmation and characterization of four hot Jupiter-type exoplanets initially detected by TESS: TOI-1295 b, TOI-2580 b, TOI-6016 b, and TOI-6130 b. Using observations with the high-resolution echelle spectrograph MaHPS on the 2.1m telescope at Wendelstein Observatory, together with NEID at Kitt Peak National Observatory and TRES at the Fred Lawrence Whipple Observatory, we confirmed the planetary nature of these four planet candidates. We also performed precise mass measurements. All four planets are found to be hot Jupiters with orbital periods between 2.4 and 4.0 days. The sizes of these planets range from 1.29 to 1.64 Jupiter radii, while their masses range from 0.6 to 1.5 Jupiter masses. Additionally, we investigated whether there are signs of other planets in the systems but have found none. Lastly, we compared the radii of our four objects to the results of an empirical study of radius inflation and see that all four demonstrate a good fit with the current models. These four planets belong to the first array of planets confirmed with MaHPS data, supporting the ability of the spectrograph to detect planets around fainter stars as faint as V=12.
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- 2025
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3. Stellar Contamination Correction Using Back-to-Back Transits of TRAPPIST-1 b and c
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Rathcke, Alexander D., Buchhave, Lars A., De Wit, Julien, Rackham, Benjamin V., August, Prune C., Diamond-Lowe, Hannah, Mendonça, João M., Bello-Arufe, Aaron, López-Morales, Mercedes, Kitzmann, Daniel, and Heng, Kevin
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Stellar surface heterogeneities, such as spots and faculae, often contaminate exoplanet transit spectra, hindering precise atmospheric characterization. We demonstrate a novel, epoch-based, model-independent method to mitigate stellar contamination, applicable to multi-planet systems with at least one airless planet. We apply this method using quasi-simultaneous transits of TRAPPIST-1 b and TRAPPIST-1 c observed on July 9, 2024, with JWST NIRSpec PRISM. These two planets, with nearly identical radii and impact parameters, are likely either bare rocks or possess thin, low-pressure atmospheres, making them ideal candidates for this technique, as variations in their transit spectra would be primarily attributed to stellar activity. Our observations reveal their transit spectra exhibit consistent features, indicating similar levels of stellar contamination. We use TRAPPIST-1 b to correct the transit spectrum of TRAPPIST-1 c, achieving a 2.5x reduction in stellar contamination at shorter wavelengths. At longer wavelengths, lower SNR prevents clear detection of contamination or full assessment of mitigation. Still, out-of-transit analysis reveals variations across the spectrum, suggesting contamination extends into the longer wavelengths. Based on the success of the correction at shorter wavelengths, we argue that contamination is also reduced at longer wavelengths to a similar extent. This shifts the challenge of detecting atmospheric features to a predominantly white noise issue, which can be addressed by stacking observations. This method enables epoch-specific stellar contamination corrections, allowing co-addition of planetary spectra for reliable searches of secondary atmospheres with signals of 60-250 ppm. Additionally, we identify small-scale cold (2000 K) and warm (2600 K) regions almost uniformly distributed on TRAPPIST-1, with overall covering fractions varying by 0.1% per hour., Comment: Resubmitted to ApJL after addressing reviewer comments
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- 2024
4. A Composite Target of a Radium Salt and a Soft Metal Matrix for Production of Ac-225 with a Proton or Electron Accelerator
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Diamond, William, Ross, Carl, and Moore, Herbert
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Physics - Medical Physics ,Physics - Instrumentation and Detectors - Abstract
The production of 225Ac using either a proton or electron accelerator requires a target of 226Ra. Radium metal is difficult to work with and so a radium salt, such as radium carbonate, is preferred as a target material. Normally available as a powder, the average density of the powder is low and the thermal conductivity is poor, thus limiting the beam power that can be dissipated in the target. This work proposes the creation of a solid mixture of a radium salt powder with a metal matrix. Although aluminum powder has been used in similar applications, we suggest that indium powder is good choice for the metal matrix in the case of radioactive radium salts. The target can be formed with low die pressure without any need for heating, thus simplifying the hot-cell equipment needed for target preparation. We describe how the solid mixture can be formed, measure its thermal conductivity and compare the value to model estimates. We calculate the yield of 225Ac under different scenarios. Calculations show that the radioactive isotopes of indium produced during the irradiation should not produce significant handling challenges post-irradiation. For the proposed target geometry and beam parameters, thermal modelling indicates that the target temperature will be below the melting point of indium and the heat flux from the surfaces will be manageable. Thermal resistance at the target interfaces is shown to have a large effect on the target temperature. Using indium powder to form the mixture, occupying about 40 % of the target volume, we find that the yield of 225Ac is 80 GBq (2 Ci) for a 10-day irradiation with a 24 MeV, 3 kW proton beam and approximately the same for three milkings of 225Ra after a 10-day irradiation with a 25 MeV, 20 kW electron beam., Comment: 37 pages, 19 figures, 10 tables
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- 2024
5. Call to Protect the Dark and Quiet Sky from Harmful Interference by Satellite Constellations
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Dark, IAU Centre for the Protection of the, Interference, Quiet Sky from Satellite Constellation, Józsa, Gyula I. G., Williams, Andrew, Green, Richard, Marsh, Isabel, Antoniadis, John, Barbosa, Domingos, Barentine, John, Blanc, Guillermo, Coelho, Bruno, Cooper, Patricia, Dalledonne, Sara, Di Vruno, Federico, Diamond, Joe, Dong, Adam, Drimmel, Ronald, Eggl, Siegfried, Habeeb, Nusrin, Heim, Jessica, Hofer, Chris, Hwang, Narae, Isidro, Mathieu, Koplow, David, Lowenthal, James, Lucatello, Sara, Lyubenova, Mariya, Massey, Robert, Peel, Mike, Rawls, Meredith, Saada, Adrien, Sanchez, Alejandro, Sanhueza, Pedro, Skidmore, Warren, Sorokin, Boris, Sreekumar, P., Stevenson, Tim, Tartari, Paula, Tornatore, Vincenza, Walker, Connie, Winkel, Benjamin, and Yakushina, Yana
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The growing number of satellite constellations in low Earth orbit (LEO) enhances global communications and Earth observation, and support of space commerce is a high priority of many governments. At the same time, the proliferation of satellites in LEO has negative effects on astronomical observations and research, and the preservation of the dark and quiet sky. These satellite constellations reflect sunlight onto optical telescopes, and their radio emission impacts radio observatories, jeopardising our access to essential scientific discoveries through astronomy. The changing visual appearance of the sky also impacts our cultural heritage and environment. Both ground-based observatories and space-based telescopes in LEO are affected, and there are no places on Earth that can escape the effects of satellite constellations given their global nature. The minimally disturbed dark and radio-quiet sky is crucial for conducting fundamental research in astronomy and important public services such as planetary defence, technology development, and high-precision geolocation. Some aspects of satellite deployment and operation are regulated by States and intergovernmental organisations. While regulatory agencies in some States have started to require operators to coordinate with their national astronomy agencies over impacts, mitigation of the impact of space objects on astronomical activities is not sufficiently regulated. To address this issue, the CPS urges States and the international community to take steps to protect the dark and quiet sky as specified in this paper., Comment: This position paper was developed by the IAU Centre for the Protection of the Dark and Quiet Sky from Satellite Constellation Interference (CPS). It can also be downloaded at the CPS website at https://cps.iau.org/news/cps-urges-action-in-first-recommendations-paper/
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- 2024
6. On the Ethical Considerations of Generative Agents
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Diamond, N'yoma and Banerjee, Soumya
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Computer Science - Computers and Society ,Computer Science - Artificial Intelligence ,Computer Science - Emerging Technologies ,Computer Science - Multiagent Systems - Abstract
The Generative Agents framework recently developed by Park et al. has enabled numerous new technical solutions and problem-solving approaches. Academic and industrial interest in generative agents has been explosive as a result of the effectiveness of generative agents toward emulating human behaviour. However, it is necessary to consider the ethical challenges and concerns posed by this technique and its usage. In this position paper, we discuss the extant literature that evaluate the ethical considerations regarding generative agents and similar generative tools, and identify additional concerns of significant importance. We also suggest guidelines and necessary future research on how to mitigate some of the ethical issues and systemic risks associated with generative agents., Comment: Accepted (poster) to Socially Responsible Language Modelling Research (SoLaR) Workshop at NeurIPS 2024
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- 2024
7. Postabortion contraceptive use among women in Nepal: results from a longitudinal cohort study.
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Karki, Sunita, Puri, Mahesh, Magar, Anupama, Foster, Diana, Raifman, Sarah, Maharjan, Dev, and Diamond-Smith, Nadia
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Contraception ,Contraceptive use ,Post-abortion contraception ,Unintended pregnancy ,Humans ,Female ,Contraception Behavior ,Nepal ,Adult ,Abortion ,Induced ,Longitudinal Studies ,Contraception ,Young Adult ,Adolescent ,Family Planning Services ,Pregnancy ,Cohort Studies ,Aftercare - Abstract
INTRODUCTION: Although the Government of Nepal has developed strategies to integrate contraceptive services with abortion care to better meet the contraceptive needs of women, data indicate that significant gaps in services remain. This paper assessed post-abortion contraceptive use, trends over 36 -months, and factors influencing usage. METHODS: Data from this paper came from an ongoing cohort study of 1831 women who sought an abortion from one of the sampled 22 government-approved health facilities across Nepal. Women were interviewed eight times over 36 months between April 2019 to Dec 2023. Bivariate and multivariate analysis were used to analyze the data. RESULTS: Results show that after abortion, 59% of women used modern contraception, with injection being the most prevalent method, followed by condoms, pills, implants, and IUD. The hazard model showed that discontinuation of modern contraception was significantly higher among women desiring additional children (aHR 0.62) and lower among literate (aHR - 0.15) and those with existing children (aHR - 0.30). Womens age, ethnicity, cohabitation with husband, households income and autonomy were not associated with continuation. CONCLUSION: After having an abortion, we found that just slightly more than half of women used modern methods of contraception; this percentage did not increase significantly over the course of three years.
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- 2024
8. Diverse microbiome functions, limited temporal variation and substantial genomic conservation within sedimentary and granite rock deep underground research laboratories.
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Amano, Yuki, Sachdeva, Rohan, Gittins, Daniel, Anantharaman, Karthik, Lei, Shufei, Valentin-Alvarado, Luis, Diamond, Spencer, Beppu, Hikari, Iwatsuki, Teruki, Mochizuki, Akihito, Miyakawa, Kazuya, Ishii, Eiichi, Murakami, Hiroaki, Jaffe, Alexander, Castelle, Cindy, Lavy, Adi, Suzuki, Yohey, and Banfield, Jillian
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Granite ,Groundwater ,Metagenomics microbiome ,Sedimentary rocks ,Stability ,Underground research laboratory - Abstract
BACKGROUND: Underground research laboratories (URLs) provide a window on the deep biosphere and enable investigation of potential microbial impacts on nuclear waste, CO2 and H2 stored in the subsurface. We carried out the first multi-year study of groundwater microbiomes sampled from defined intervals between 140 and 400 m below the surface of the Horonobe and Mizunami URLs, Japan. RESULTS: We reconstructed draft genomes for > 90% of all organisms detected over a four year period. The Horonobe and Mizunami microbiomes are dissimilar, likely because the Mizunami URL is hosted in granitic rock and the Horonobe URL in sedimentary rock. Despite this, hydrogen metabolism, rubisco-based CO2 fixation, reduction of nitrogen compounds and sulfate reduction are well represented functions in microbiomes from both URLs, although methane metabolism is more prevalent at the organic- and CO2-rich Horonobe URL. High fluid flow zones and proximity to subsurface tunnels select for candidate phyla radiation bacteria in the Mizunami URL. We detected near-identical genotypes for approximately one third of all genomically defined organisms at multiple depths within the Horonobe URL. This cannot be explained by inactivity, as in situ growth was detected for some bacteria, albeit at slow rates. Given the current low hydraulic conductivity and groundwater compositional heterogeneity, ongoing inter-site strain dispersal seems unlikely. Alternatively, the Horonobe URL microbiome homogeneity may be explained by higher groundwater mobility during the last glacial period. Genotypically-defined species closely related to those detected in the URLs were identified in three other subsurface environments in the USA. Thus, dispersal rates between widely separated underground sites may be fast enough relative to mutation rates to have precluded substantial divergence in species composition. Species overlaps between subsurface locations on different continents constrain expectations regarding the scale of global subsurface biodiversity. CONCLUSIONS: Our analyses reveal microbiome stability in the sedimentary rocks and surprising microbial community compositional and genotypic overlap over sites separated by hundreds of meters of rock, potentially explained by dispersal via slow groundwater flow or during a prior hydrological regime. Overall, microbiome and geochemical stability over the study period has important implications for underground storage applications.
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- 2024
9. Density fluctuation statistics and turbulence spreading at the edge of L–mode plasmas
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Khabanov, FO, Hong, R, Diamond, PH, Tynan, GR, Yan, Z, McKee, GR, Chrystal, C, Scotti, F, Yu, G, Zamperini, SA, and Zhu, Y
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Nuclear and Plasma Physics ,Physical Sciences ,tokamak ,edge density fluctuations ,turbulence spreading ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Fluids & Plasmas ,Nuclear and plasma physics - Abstract
Long-wavelength density fluctuations ( k ρ i 0.97, indicating the prevalence of density ‘voids’ at inner radii and density ‘blobs’ at outer radii and outside of the separatrix. The turbulence intensity flux ⟨ v ~ r n ~ 2 ⟩ is calculated to characterize turbulence spreading at the plasma edge. During ECH/NBI power ramps and at counter- I p injected torque, ⟨ v ~ r n ~ 2 ⟩ is directed inward inside the separatrix, which is evidence of inward spreading of turbulence intensity from the edge gradient region caused by the inner propagation of density ‘voids’. Significantly weaker ⟨ v ~ r n ~ 2 ⟩ is observed with co- I p torque. A correlation between co- I p torque, turbulence intensity δ n / n at ρ = 0.97, and increased srape-off layer (SOL) heat flux decay length λ q is found in the torque scan scenario, showing that edge turbulence plays a material role in determining the SOL conditions and heat flux width.
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- 2024
10. Pregnancy intentions and outcomes among young married women in Nepal
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Lansdale, Aimee J, Puri, Mahesh C, and Diamond-Smith, Nadia
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Pediatric ,Behavioral and Social Science ,Pregnancy ,Contraception/Reproduction ,Maternal Health ,Women's Health ,Clinical Research ,Prevention ,Reproductive health and childbirth ,Good Health and Well Being ,Nepal ,barriers ,contraception ,pregnancy ,pregnancy intention ,pregnancy outcome ,reproductive health ,unintended - Abstract
BackgroundApproximately 44% of Nepalese women ages 15-49, desiring to avoid pregnancy, do not use modern contraceptives, resulting in an estimated 539,000 unintended pregnancies annually.ObjectivesThis study aims to investigate the association between young, newly married women's pregnancy intentions and subsequent pregnancies.Study designData were collected longitudinally from 200 recently married women ages 18-25 in Nepal. Surveys conducted every six months over 18 months covered various health domains. The study used mixed-effects logistic regression models to account for repeated measurement of correlated data over time. The primary outcome was pregnancy. Pregnancy intention was determined based on responses to, "When would you like to have a child in case you were to have one?" Participants were recategorized into a dichotomous variable for analytical purposes: "Right away" or "Not right away."ResultsA total of 133 participants became pregnant during the study, with sociodemographic characteristics showing minimal differences between pregnant and nonpregnant groups. Women intending to become pregnant right away had significantly higher odds of becoming pregnant (OR, 4.03; 95% CI, 2.51-6.48) after adjusting for covariates. Among those not intending immediate pregnancy, over 70% became pregnant, suggesting potential barriers to achieving reproductive goals.ConclusionsYoung, newly married women in Nepal intending immediate pregnancy have higher odds of becoming pregnant. However, a substantial proportion of those hoping to delay pregnancy still experience unintended pregnancies, indicating challenges in meeting reproductive goals. The findings underscore the need for addressing barriers to contraceptive access and societal norms impacting women's reproductive autonomy in Nepal.
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- 2024
11. A Single-center Experience of Coccidioides Meningitis in Immunocompetent Patients: Case Series and Literature Review.
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Rajmohan, Ravi, Deyell, Jacob, Harris, Mark, Gramajo-Aponte, Kevin, Fote, Gianna, Davies, Jordan, Chen, Nita, Diamond, Catherine, and Lu, Xiaoying
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climate change ,coccidioidal meningitis ,coccidioides ,fungal meningitis ,immunocompetence - Abstract
Recently, the California Department of Public Health issued an advisory related to the substantial rise in Coccidioidomycosis in California, which has been attributed in part to climate change and rapid housing development. Most cases are self-limiting, but some may spread to the meninges, resulting in coccidioidal meningitis (CM). Many providers mistakenly presume that CM is limited to patients who are immunocompromised. In this case series and literature review, we present 12 cases of CM in immunocompetent individuals seen at a single tertiary academic center between 1 January 2019 and 31 December 2023. All 12 cases developed complications, with 10 requiring ventriculoperitoneal shunting, 6 having spinal cord involvement (5 with cervical spine involvement), 4 having strokes, and 3 dying from complications related to CM. It is important to recognize CM as it may be life-threatening if not promptly diagnosed.
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- 2024
12. J-TEXT achievements in turbulence and transport in support of future device/reactor
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Zhipeng, CHEN, HUANG, Zhangsheng, JIANG, Min, Ting, LONG, Lu, WANG, Weixin, GUO, Zhoujun, YANG, Hai, LIU, Tao, LAN, Kaijun, ZHAO, Yuhong, XU, Rui, KE, Youwen, SUN, Hanhui, LI, Wen, HE, ZHUANG, Ge, Yuejiang, SHI, ZHONG, Wulyu, Yonghua, DING, LIANG, Yunfeng, Wenjing, TIAN, Xin, XU, ZHANG, Guodong, HUSSAIN, MS, and DIAMOND, Patrick H
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Nuclear and Plasma Physics ,Physical Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Fluids & Plasmas ,Nuclear and plasma physics - Abstract
Abstract: Following the reconstruction of the TEXT tokamak at Huazhong University of Science and Technology in China, renamed as J-TEXT, a plethora of experimental and theoretical investigations has been conducted to elucidate the intricacies of turbulent transport within the tokamak configuration. These endeavors encompass not only the J-TEXT device’s experimental advancements but also delve into critical issues pertinent to the optimization of future fusion devices and reactors. The research includes topics on the suppression of turbulence, flow drive and damping, density limit, non-local transport, intrinsic toroidal flow, turbulence and flow with magnetic islands, turbulent transport in the stochastic layer, and turbulence and zonal flow with energetic particles or helium ash. Several important achievements have been made in the last few years, which will be further elaborated upon in this comprehensive review.
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- 2024
13. Hot Rocks Survey I : A shallow eclipse for LHS 1478 b
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August, Prune C., Buchhave, Lars A., Diamond-Lowe, Hannah, Mendonça, João M., Gressier, Amélie, Rathcke, Alexander D., Allen, Natalie H., Fortune, Mark, Jones, Kathryn D., Meier-Valdés, Erik A., Demory, Brice-Olivier, Espinoza, Nestor, Fisher, Chloe E., Gibson, Neale P., Heng, Kevin, Hoeijmakers, Jens, Hooton, Matthew J., Kitzmann, Daniel, and Prinoth, Bibiana
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Astrophysics - Earth and Planetary Astrophysics - Abstract
M dwarf systems offer a unique opportunity to study terrestrial exoplanetary atmospheres due to their smaller size and cooler temperatures. However, due to the extreme conditions these host stars impose, it is unclear whether their small, close-in rocky planets are able to retain any atmosphere at all. The Hot Rocks Survey aims to answer this question by targeting nine different M dwarf rocky planets spanning a range of planetary and stellar properties. LHS 1478 b orbits an M3-type star, has an equilibrium temperature of Teq = 585 K and experiences an instellation 21 times greater than that of Earth. We observe two secondary eclipses using photometric imaging at 15 um using the Mid-Infrared Instrument on the James Webb Space Telescope (JWST MIRI) to measure thermal emission from the dayside of the planet. We then compare these values to different atmospheric scenarios to evaluate potential heat transport and CO2 absorption signatures. We find a secondary eclipse depth of 146 +/- 56 ppm based on the first observation, while the second observation results in a non-detection due to significantly larger unexplained systematics. Based on the first observation alone, we can reject the null hypothesis of the dark (zero Bond albedo) no atmosphere bare rock model with a confidence level of 3.4 sigma. For an airless body with a Bond albedo of A=0.2, the significance decreases to 2.9 sigma. The secondary eclipse depth is consistent with the majority of atmospheric scenarios we considered, which all involve atmospheres which include different concentrations of CO2, and surface pressures from 0.1 to 10 bar. However, we stress that the two observations from our program do not yield consistent results, and more observations are needed to verify our findings. The Hot Rocks Survey serves as a relevant primer for future endeavors such as the Director's Discretionary Time (DDT) Rocky Worlds program., Comment: Submitted to A&A
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- 2024
14. The Thermal Emission Spectrum of the Nearby Rocky Exoplanet LTT 1445A b from JWST MIRI/LRS
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Wachiraphan, Patcharapol, Berta-Thompson, Zachory K., Diamond-Lowe, Hannah, Winters, Jennifer G., Murray, Catriona, Zhang, Michael, Xue, Qiao, Morley, Caroline V., Rosario-Franco, Marialis, and Duvvuri, Girish M.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The nearby transiting rocky exoplanet LTT 1445A b presents an ideal target for studying atmospheric retention in terrestrial planets orbiting M dwarfs. It is cooler than many rocky exoplanets yet tested for atmospheres, receiving a bolometric instellation similar to Mercury's. Previous transmission spectroscopy ruled out a light H/He-dominated atmosphere but could not distinguish between a bare-rock, a high-MMW, or a cloudy atmosphere. We present new secondary eclipse observations using JWST's MIRI/LRS, covering the 5-12 $\mu$m range. From these observations, we detect a broadband secondary eclipse depth of 41 $\pm$ 9 ppm and measure a mid-eclipse timing consistent with a circular orbit (at 1.7$\sigma$). From its emission spectrum, the planet's dayside brightness temperature is constrained to 525 $\pm$ 15 K, yielding a temperature ratio relative to the maximum average dayside temperature from instant thermal reradiation by a rocky surface $R$ = $T_{\rm day,obs}/T_{\rm max}$ = 0.952 $\pm$ 0.057, consistent with emission from a dark rocky surface. From an energy balance perspective, such a warm dayside temperature disfavors thick atmospheres, excluding $\sim$100 bar atmospheres with Bond albedo $>$ 0.08 at the 3$\sigma$ level. Furthermore, forward modeling of atmospheric emission spectra disfavor simple 100\% CO$_2$ atmospheres with surface pressures of 1, 10, and 100 bar at 4.2$\sigma$, 6.6$\sigma$, and 6.8$\sigma$ confidence, respectively. These results suggest that LTT 1445A b lacks a very thick CO$_2$ atmosphere, possibly due to atmospheric erosion driven by stellar activity. However, the presence of a moderately thin atmosphere (similar to those on Mars, Titan, or Earth) remains uncertain., Comment: 31 pages, 14 figures, submitted to AJ
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- 2024
15. Formation of Jupiter-Mass Binary Objects through photoerosion of fragmenting cores
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Diamond, Jessica L. and Parker, Richard J.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The recent discovery of tens of Jupiter-mass binary objects (JuMBOs) in the Orion Nebula Cluster with the James Webb Space Telescope has intensified the debate on the origin of free-floating planetary mass objects within star-forming regions. The JuMBOs have masses below the opacity limit for fragmentation, but have very wide separations (10s - 100s au), suggesting that they did not form in a similar manner to other substellar mass binaries. Here, we propose that the theory of photoerosion of prestellar cores by Lyman continuum radiation from massive stars could explain the JuMBOs in the ONC. We find that for a range of gas densities the final substellar mass is comfortably within the JuMBO mass range, and that the separations of the JuMBOs are consistent with those of more massive (G- and A-type) binaries, that would have formed from the fragmentation of the cores had they not been photoeroded. The photoerosion mechanism is most effective within the HII region(s) driven by the massive star(s). The majority of the observed JuMBOs lie outside of these regions in the ONC, but may have formed within them and then subsequently migrated due to dynamical evolution., Comment: 9 pages, 4 figures, accepted for publication in ApJ
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- 2024
16. Asymptotic Lower Bounds for the Feedback Arc Set Problem in Random Graphs
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Diamond, Harvey, Kon, Mark, and Raphael, Louise
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Mathematics - Combinatorics ,05C80 (Primary) 05C85, 68W40 (Secondary) - Abstract
Given a directed graph, the Minimal Feedback Arc Set (FAS) problem asks for a minimal set of arcs in a directed graph, which, when removed, results in an acyclic graph. Equivalently, the FAS problem asks to find an ordering of the vertices that minimizes the number of feedback arcs. This is considered an algorithmic problem of central importance in discrete mathematics, with varied applications to problems in computer science and operations research. Berger and Shor, in 1990, developed upper bounds for the FAS problem in general directed graphs. Here we find asymptotic lower bounds for the FAS problem in a class of random graphs given by the Erd\H{o}s-R\'{e}nyi model G(n,M), with n vertices and M (undirected) edges, the latter randomly chosen. Each edge is then randomly given a direction to form our directed graph. Our interest is in developing a $\textit{lower}$ bound for the minimal feedback arc set that holds with probability 1 as $n\rightarrow \infty$. We show that $$Pr\left(\textbf{Y}^* \le M \left( \frac{1}{2} -\sqrt{\frac{\log n}{2\Delta_{av}}}\right)\right)$$ approaches zero exponentially in $n$, with $\textbf{Y}^*$ the (random) size of the minimal feedback set and $\Delta_{av}=M/n$ the average vertex degree. We subsequently apply our lower bounds to a set of experimental FAS data on related random graphs, as developed by Kathrin Hanauer. Not only does our formula provide a reasonably close lower bound for the minimal set, but the approximation that lies midway between our lower bound and the obvious upper bound of $M/2$ is remarkably close to the computed FAS data over a range of experiments, suggesting that this approximation may in fact be asymptotic to the minimal number of feedback arcs, for large $n$, and an excellent estimate even for moderate values., Comment: 11 pages, 4 figures
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- 2024
17. The Outflowing [OII] Nebulae of Compact Starburst Galaxies at z $\sim$ 0.5
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Perrotta, Serena, Coil, Alison L., Rupke, David S. N., Ning, Wenmeng, Duong, Brendan, Diamond-Stanic, Aleksandar M., Fielding, Drummond B., Geach, James E., Hickox, Ryan C., Moustakas, John, Rudnick, Gregory H., Sell, Paul H., Swiggum, Cameren N., and Tremonti, Christy A.
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Astrophysics - Astrophysics of Galaxies - Abstract
High-velocity outflows are ubiquitous in compact, massive (M$_* \sim$ 10$^{11}$ M$_{\odot}$), z $\sim$ 0.5 galaxies with extreme star formation surface densities ($\Sigma_{SFR} \sim$ 2000 M$_{\odot}$ yr$^{-1}$ kpc$^{-2}$). We have previously detected and characterized these outflows using MgII absorption lines. To probe their full extent, we present Keck/KCWI integral field spectroscopy of the [OII] and MgII emission nebulae surrounding all of the 12 galaxies in this study. We find that [OII] is more effective than MgII in tracing low surface brightness, extended emission in these galaxies. The [OII] nebulae are spatially extended beyond the stars, with radial extent R$_{90}$ between 10 and 40 kpc. The nebulae exhibit non-gravitational motions, indicating galactic outflows with maximum blueshifted velocities ranging from -335 to -1920 km s$^{-1}$. The outflow kinematics correlate with the bursty star formation histories of these galaxies. Galaxies with the most recent bursts of star formation (within the last $<$ 3 Myr) exhibit the highest central velocity dispersions ($\sigma >$ 400 km s$^{-1}$), while the oldest bursts have the lowest-velocity outflows. Many galaxies exhibit both high-velocity cores and more extended, slower-moving gas indicative of multiple outflow episodes. The slower, larger outflows occurred earlier and have decelerated as they propagate into the CGM and mix on timescales $>$ 50 Myr., Comment: Accepted for publication in The Astrophysical Journal
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- 2024
18. Illuminating dark objects with dark matter lampshades
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Bramante, Joseph, Diamond, Melissa D., and Kim, J. Leo
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High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We demonstrate a new technique to search for dark compact objects. When dark matter comprising a dark compact object interacts with photons, the compact object can disperse light traveling though it. As these objects pass between the Earth and a distant star, they act as "lampshades" that dim the star. We examine how dimming effects from clumps of dark matter in the galaxy could be searched for in microlensing surveys, which measure the brightness of stars as a function of time. Using the EROS-2 and OGLE surveys, we show that a dimming analysis of existing data can be used to constrain dark sectors, and could be used to discover dark matter in compact objects., Comment: 12 pages, 6 figures
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- 2024
19. Migrating English Language Instruction from Face to Face to Online Learning
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Gwendolyn M. Williams, Hyeon-Jean Yoo, and Mary S. Diamond
- Abstract
This paper describes a qualitative study that examined the lived experience of 50 English language instructors who transitioned from in-person teaching to online instruction during the COVID pandemic of 2020. The purpose of this study focused on the contrast between systematic online English language teacher preparation and rapid migration to identify strategies that can facilitate sudden shifts in instructional contexts. The data that was collected through snowball sampling with an anonymous Qualtrics survey revealed that during this rapid transition, instructors struggled with learning the technological pedagogy skills, establishing connections with their students, implementing assessment practices, and organizing student interactions. After a description of the findings, the article concludes with implications for teacher education for online English language instruction.
- Published
- 2024
20. Renewing the Case for Regionalism: EU Transnational Governance in an Era of Regulatory Nationalism
- Author
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Diamond Ashiagbor
- Subjects
Law of Europe ,KJ-KKZ ,Law in general. Comparative and uniform law. Jurisprudence ,K1-7720 - Published
- 2020
- Full Text
- View/download PDF
21. Cryo-EM structure of Alzheimers disease tau filaments with PET ligand MK-6240.
- Author
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Kunach, Peter, Vaquer-Alicea, Jaime, Smith, Matthew, Monistrol, Jim, Hopewell, Robert, Moquin, Luc, Therriault, Joseph, Tissot, Cecile, Rahmouni, Nesrine, Massarweh, Gassan, Soucy, Jean-Paul, Guiot, Marie-Christine, Shoichet, Brian, Rosa-Neto, Pedro, Diamond, Marc, and Shahmoradian, Sarah
- Subjects
Alzheimer Disease ,tau Proteins ,Positron-Emission Tomography ,Humans ,Cryoelectron Microscopy ,Ligands ,Brain ,Autoradiography ,Female ,Male ,Carbolines - Abstract
Positron Emission Tomography (PET) ligands have advanced Alzheimers disease (AD) diagnosis and treatment. Using autoradiography and cryo-EM, we identify AD brain tissue with elevated tau burden, purify filaments, and determine the structure of second-generation high avidity PET ligand MK-6240 at 2.31 Å resolution, which bound at a 1:1 ratio within the cleft of tau paired-helical filament (PHF), engaging with glutamine 351, lysine 353, and isoleucine 360. This information elucidates the basis of MK-6240 PET in quantifying PHF deposits in AD and may facilitate the structure-based design of superior ligands against tau amyloids.
- Published
- 2024
22. Hypophosphatemia Correction Reduces ICANS Incidence and Duration in CAR T-cell Therapy: A Pooled Clinical Trial Analysis.
- Author
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Tang, Jack, Lafeuille, Penelope, Socolov, Alexandru, Diamond, Sheila, Aptekar, Jacob, Moore, Theodore, Nie, Esther, Hanudel, Mark, and Nowicki, Theodore
- Subjects
Humans ,Hypophosphatemia ,Immunotherapy ,Adoptive ,Male ,Female ,Retrospective Studies ,Incidence ,Neurotoxicity Syndromes ,Middle Aged ,Adult ,Aged ,Clinical Trials as Topic ,Young Adult ,Receptors ,Chimeric Antigen ,Adolescent - Abstract
UNLABELLED: A common complication of chimeric antigen receptor (CAR) T-cell therapy is immune effector cell-associated neurotoxicity syndrome (ICANS), which presents with encephalopathy, aphasia, inattention, somnolence, seizures, weakness, or cerebral edema. Despite its significant morbidity, there are currently no effective targeted treatments. Given the clinical similarities between ICANS and the neurological manifestations of acute hypophosphatemia, we retrospectively reviewed 499 patients treated with CD19-targeted CAR T-cell therapy across multiple clinical trials between 2015 and 2020. In addition to clinical toxicities experienced by the patients, we also interrogated the impact of serum electrolyte data and repletion of corresponding electrolyte deficiencies with ICANS incidence, severity, and duration. Hypophosphatemia was a common occurrence in CAR T-cell recipients and the only electrolyte derangement associated with a significantly higher cumulative incidence of ICANS. Moreover, phosphorus repletion in patients with hypophosphatemia was associated with significantly decreased ICANS incidence and duration. Hypophosphatemia was uniquely associated with encephalopathy neurological adverse events, which also showed the strongest positive correlation with both ICANS and cytokine release syndrome severity. These findings suggest that serum phosphorus could be a reliable biomarker for ICANS, and expeditious, goal-directed phosphorus repletion in response to serum hypophosphatemia could be a safe, inexpensive, and widely available intervention for such patients. SIGNIFICANCE: Herein we show that phosphorus repletion in patients with hypophosphatemia receiving anti-CD19 chimeric antigen receptor T-cell therapeutics was associated with significantly decreased immune effector cell-associated neurotoxicity syndrome (ICANS) incidence and symptom duration. Given the significant morbidity associated with ICANS and lack of targeted interventions, hypophosphatemia may serve as both a useful biomarker and an inexpensive intervention for ICANS.
- Published
- 2024
23. Has Reducing Ship Emissions Brought Forward Global Warming?
- Author
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Gettelman, A, Christensen, MW, Diamond, MS, Gryspeerdt, E, Manshausen, P, Stier, P, Watson‐Parris, D, Yang, M, Yoshioka, M, and Yuan, T
- Subjects
Earth Sciences ,Atmospheric Sciences ,Climate Action ,climate ,aerosols ,sulfur ,global warming ,Meteorology & Atmospheric Sciences - Abstract
Abstract: Ships brighten low marine clouds from emissions of sulfur and aerosols, resulting in visible “ship tracks”. In 2020, new shipping regulations mandated an ∼80% reduction in the allowed fuel sulfur content. Recent observations indicate that visible ship tracks have decreased. Model simulations indicate that since 2020 shipping regulations have induced a net radiative forcing of +0.12 Wm−2. Analysis of recent temperature anomalies indicates Northern Hemisphere surface temperature anomalies in 2022–2023 are correlated with observed cloud radiative forcing and the cloud radiative forcing is spatially correlated with the simulated radiative forcing from the 2020 shipping emission changes. Shipping emissions changes could be accelerating global warming. To better constrain these estimates, better access to ship position data and understanding of ship aerosol emissions are needed. Understanding the risks and benefits of emissions reductions and the difficultly in robust attribution highlights the large uncertainty in attributing proposed deliberate climate intervention.
- Published
- 2024
24. Desiccated Cyanobacteria Serve As Efficient Plasmid DNA Carriers in Space Flight.
- Author
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Kakouridis, Anne, Diamond, Spencer, Eng, Thomas, Mills, Heath J, Gámez Holzhaus, Olivia, Summers, Michael L, Garcia-Pichel, Ferran, and Mukhopadhyay, Aindrila
- Subjects
Biological Sciences ,Industrial Biotechnology ,Genetics ,Cyanobacteria ,InternationalSpace Station ,Nostoc punctiforme ,Space Flight ,Space Travel ,International Space Station ,Medicinal and Biomolecular Chemistry ,Biochemistry and Cell Biology ,Biomedical Engineering ,Biochemistry and cell biology ,Bioinformatics and computational biology - Abstract
Effective transport of biological systems as cargo during space travel is a critical requirement to use synthetic biology and biomanufacturing in outer space. Bioproduction using microbes will drive the extent to which many human needs can be met in environments with limited resources. Vast repositories of biological parts and strains are available to meet this need, but their on-site availability requires effective transport. Here, we explore an approach that allows DNA plasmids, ubiquitous synthetic biology parts, to be safely transported to the International Space Station and back to the Kennedy Space Center without low-temperature or cryogenic stowage. Our approach relied on the cyanobacterium Nostoc punctiforme PC73102, which is naturally tolerant to prolonged desiccation. Desiccated N. punctiforme was able to carry the non-native pSCR119 plasmid as intracellular cargo safely to space and back. Upon return to the laboratory, the extracted plasmid showed no DNA damage or additional mutations and could be used as intended to transform the model synbio host Escherichia coli to bestow kanamycin resistance. This proof-of-concept study provides the foundation for a ruggedized transport host for DNA to environments where there is a need to reduce equipment and infrastructure for biological parts stowage and storage.
- Published
- 2024
25. Epics Deployment at Fermilab
- Author
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Hanlet, P., Gonzalez, M., Diamond, J., and Martin, K. S.
- Subjects
Physics - Accelerator Physics - Abstract
Fermilab has traditionally not been an EPICS house; as such expertise in EPICS is limited and scattered. PIP-II will be using EPICS for its control system. When in operation, it will need to interface with the existing, modernized (see ACORN) legacy control system. Treating EPICS controls at Fermilab as a green field, we have developed and deployed a software pipeline which addresses these needs and presents to developers a tested and robust software framework, including template IOCs from which new developers can quickly deploy new front ends, aka IOCs. In this presentation, motivation for this work, implementation of a continuous integration/continuous deployment pipeline, testing, template IOCs, and the deployment of user services/applications will be discussed. This new infrastructure of IOCs and services is being developed and used in the PIP-II cryomodule teststand; our experiences and lessons learned will be also be discussed., Comment: 19th Biennial International Conference on Accelerator and Large Experimental Physics Control Systems (ICALEPCS 2023)
- Published
- 2024
26. Evaluating Large Language Models with fmeval
- Author
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Schwöbel, Pola, Franceschi, Luca, Zafar, Muhammad Bilal, Vasist, Keerthan, Malhotra, Aman, Shenhar, Tomer, Tailor, Pinal, Yilmaz, Pinar, Diamond, Michael, and Donini, Michele
- Subjects
Computer Science - Computation and Language ,Computer Science - Machine Learning - Abstract
fmeval is an open source library to evaluate large language models (LLMs) in a range of tasks. It helps practitioners evaluate their model for task performance and along multiple responsible AI dimensions. This paper presents the library and exposes its underlying design principles: simplicity, coverage, extensibility and performance. We then present how these were implemented in the scientific and engineering choices taken when developing fmeval. A case study demonstrates a typical use case for the library: picking a suitable model for a question answering task. We close by discussing limitations and further work in the development of the library. fmeval can be found at https://github.com/aws/fmeval.
- Published
- 2024
27. Light Dark Matter Constraints from SuperCDMS HVeV Detectors Operated Underground with an Anticoincidence Event Selection
- Author
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SuperCDMS Collaboration, Albakry, M. F., Alkhatib, I., Alonso-González, D., Amaral, D. W. P., Anczarski, J., Aralis, T., Aramaki, T., Arnquist, I. J., Langroudy, I. Ataee, Azadbakht, E., Bathurst, C., Bhattacharyya, R., Biffl, A. J., Brink, P. L., Buchanan, M., Bunker, R., Cabrera, B., Calkins, R., Cameron, R. A., Cartaro, C., Cerdeño, D. G., Chang, Y. -Y., Chaudhuri, M., Chen, J. -H., Chen, R., Chott, N., Cooley, J., Coombes, H., Cushman, P., Cyna, R., Das, S., De Brienne, F., Dharani, S., di Vacri, M. L., Diamond, M. D., Elwan, M., Fascione, E., Figueroa-Feliciano, E., Fouts, K., Fritts, M., Germond, R., Ghaith, M., Golwala, S. R., Hall, J., Harms, S. A. S., Harris, K., Hassan, N., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jardin, D., Kashyap, V. K. S., Keller, S. T. D., Kelsey, M. H., Kennard, K. T., Kubik, A., Kurinsky, N. A., Lee, M., Leyva, J., Liu, J., Liu, Y., Loer, B., Asamar, E. Lopez, Lukens, P., MacFarlane, D. B., Mahapatra, R., Mammo, J. S., Mast, N., Mayer, A. J., Theenhausen, H. Meyer zu, Michaud, É., Michielin, E., Mirabolfathi, N., Mirzakhani, M., Mohanty, B., Monteiro, D., Nelson, J., Neog, H., Novati, V., Orrell, J. L., Osborne, M. D., Oser, S. M., Pandey, L., Pandey, S., Partridge, R., Pedreros, D. S., Peng, W., Perna, L., Perry, W. L., Podviianiuk, R., Poudel, S. S., Pradeep, A., Pyle, M., Rau, W., Reid, E., Ren, R., Reynolds, T., Rios, M., Roberts, A., Robinson, A. E., Ryan, J. L., Saab, T., Sadek, D., Sadoulet, B., Sahoo, S. P., Saikia, I., Sander, J., Sattari, A., Schmidt, B., Schnee, R. W., Scorza, S., Serfass, B., Simchony, A., Sincavage, D. J., Sinervo, P., Street, J., Sun, H., Tanner, E., Terry, G. D., Toback, D., Verma, S., Villano, A. N., von Krosigk, B., Watkins, S. L., Wen, O., Williams, Z., Wilson, M. J., Winchell, J., Wykoff, K., Yellin, S., Young, B. A., Yu, T. C., Zatschler, B., Zatschler, S., Zaytsev, A., Zhang, E., Zheng, L., Zuniga, A., and Zurowski, M. J.
- Subjects
High Energy Physics - Experiment ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Physics - Instrumentation and Detectors - Abstract
This article presents constraints on dark-matter-electron interactions obtained from the first underground data-taking campaign with multiple SuperCDMS HVeV detectors operated in the same housing. An exposure of 7.63 g-days is used to set upper limits on the dark-matter-electron scattering cross section for dark matter masses between 0.5 and 1000 MeV/$c^2$, as well as upper limits on dark photon kinetic mixing and axion-like particle axioelectric coupling for masses between 1.2 and 23.3 eV/$c^2$. Compared to an earlier HVeV search, sensitivity was improved as a result of an increased overburden of 225 meters of water equivalent, an anticoincidence event selection, and better pile-up rejection. In the case of dark-matter-electron scattering via a heavy mediator, an improvement by up to a factor of 25 in cross-section sensitivity was achieved., Comment: 7 pages + title and references, 4 figures, and 1 table
- Published
- 2024
28. TreeSeg: Hierarchical Topic Segmentation of Large Transcripts
- Author
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Gklezakos, Dimitrios C., Misiak, Timothy, and Bishop, Diamond
- Subjects
Computer Science - Computation and Language - Abstract
From organizing recorded videos and meetings into chapters, to breaking down large inputs in order to fit them into the context window of commoditized Large Language Models (LLMs), topic segmentation of large transcripts emerges as a task of increasing significance. Still, accurate segmentation presents many challenges, including (a) the noisy nature of the Automatic Speech Recognition (ASR) software typically used to obtain the transcripts, (b) the lack of diverse labeled data and (c) the difficulty in pin-pointing the ground-truth number of segments. In this work we present TreeSeg, an approach that combines off-the-shelf embedding models with divisive clustering, to generate hierarchical, structured segmentations of transcripts in the form of binary trees. Our approach is robust to noise and can handle large transcripts efficiently. We evaluate TreeSeg on the ICSI and AMI corpora, demonstrating that it outperforms all baselines. Finally, we introduce TinyRec, a small-scale corpus of manually annotated transcripts, obtained from self-recorded video sessions.
- Published
- 2024
29. High-energy spectra of LTT 1445A and GJ 486 reveal flares and activity
- Author
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Diamond-Lowe, H., King, G. W., Youngblood, A., Brown, A., Howard, W. S., Winters, J. G., Wilson, D. J., France, K., Mendonça, J. M., Buchhave, L. A., Corrales, L., Kreidberg, L., Medina, A. A., Bean, J. L., Berta-Thompson, Z. K., Evans-Soma, T. M., Froning, C., Duvvuri, G. M., Kempton, E. M. -R., Miguel, Y., Pineda, J. S., and Schneider, C.
- Subjects
Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The high-energy radiative output, from the X-ray to the ultraviolet, of exoplanet host stars drives photochemical reactions and mass loss in the upper regions of planetary atmospheres. In order to place constraints on the atmospheric properties of the three closest terrestrial exoplanets transiting M dwarfs, we observe the high-energy spectra of the host stars LTT1445A and GJ486 in the X-ray with XMM-Newton and Chandra and in the ultraviolet with HST/COS and STIS. We combine these observations with estimates of extreme ultraviolet flux, reconstructions of the Ly-a lines, and stellar models at optical and infrared wavelengths to produce panchromatic spectra from 1A--20um for each star. While LTT1445Ab, LTT1445Ac, and GJ486b do not possess primordial hydrogen-dominated atmospheres, we calculate that they are able to retain pure CO2 atmospheres if starting with 10, 15, and 50% of Earth's total CO2 budget, respectively, in the presence of their host stars' stellar wind. We use age-activity relationships to place lower limits of 2.2 and 6.6 Gyr on the ages of the host stars LTT1445A and GJ486. Despite both LTT1445A and GJ486 appearing inactive at optical wavelengths, we detect flares at ultraviolet and X-ray wavelengths for both stars. In particular, GJ486 exhibits two flares with absolute energies of 10^29.5 and 10^30.1 erg (equivalent durations of 4357+/-96 and 19724+/-169 s) occurring three hours apart, captured with HST/COS G130M. Based on the timing of the observations, we suggest that these high-energy flares are related and indicative of heightened flaring activity that lasts for a period of days, but our interpretations are limited by sparse time-sampling. Consistent high-energy monitoring is needed to determine the duration and extent of high-energy activity on individual M dwarfs, as well as the population as a whole., Comment: 21 pages, published in A&A
- Published
- 2024
- Full Text
- View/download PDF
30. Dissipative Dark Cosmology: From Early Matter Dominance to Delayed Compact Objects
- Author
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Bramante, Joseph, Cappiello, Christopher V., Diamond, Melissa D., Kim, J. Leo, Liu, Qinrui, and Vincent, Aaron C.
- Subjects
High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We demonstrate a novel mechanism for producing dark compact objects and black holes through a dark sector, where all the dark matter can be dissipative. Heavy dark sector particles with masses above $10^4$ GeV can come to dominate the Universe and yield an early matter-dominated era before Big Bang Nucleosynthesis (BBN). Density perturbations in this epoch can grow and collapse into tiny dark matter halos, which cool via self interactions. The typical halo size is set by the Hubble length once perturbations begin growing, offering a straightforward prediction of the halo size and evolution depending on ones choice of dark matter model. Once these primordial halos have formed, a thermal phase transition can then shift the Universe back into radiation domination and standard cosmology. These halos can continue to collapse after BBN, resulting in the late-time formation of fragmented dark compact objects and sub-solar mass primordial black holes. We find that these compact objects can constitute a sizable fraction of all of dark matter. The resulting fragments can have masses between $10^{20}$ g to $10^{32}$ g, with radii ranging from $10^{-2}$ m to $10^5$ m, while the black holes can have masses between $10^{8}$ g to $10^{34}$ g. Furthermore, a unique feature of this model is the late-time formation of black holes which can evaporate today. We compare where these objects lie with respect to current primordial black hole and and massive (astrophysical) compact halo object constraints., Comment: 12 pages, 6 figures. Accepted version
- Published
- 2024
- Full Text
- View/download PDF
31. Improvement in vision-related quality-of-life using the NEI-VFQ-9 over 1-year in the Manhattan Vision Screening and Follow-up Study (NYC-SIGHT)
- Author
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Hark, Lisa A., Gorroochurn, Prakash, Tang, Haotian, Torres, Desiree R., Blackburn, Brendan, Maruri, Stefania C., Diamond, Daniel F., Harizman, Noga, Wang, Qing, Wang, Yujia, Liebmann, Jeffrey M., Cioffi, George A., Horowitz, Jason D., and Park, Lisa
- Published
- 2025
- Full Text
- View/download PDF
32. Children’s executive functioning and health behaviors across pediatric life stages and ecological contexts
- Author
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Kelly, Nichole R., Kosty, Derek, Bodovski, Yosef, Blackwell, Courtney K., Ganiban, Jody M., Neiderhiser, Jenae M., Dabelea, Dana, Gilbert-Diamond, Diane, Aschner, Judy L., Bastain, Theresa M., Breton, Carrie V., Bush, Nicole R., Calub, Catrina A., Camargo, Carlos A., Camerota, Marie, Croen, Lisa A., Elliott, Amy J., Enlow, Michelle Bosquet, Ferrara, Assiamira, Hartert, Tina, Joseph, Robert M., Karagas, Margaret R., Kelly, Rachel S., Lyall, Kristen, Magee, Kelsey E., McEvoy, Cindy T., Merced-Nieves, Francheska M., O’Connor, Thomas G., Santarossa, Sara, Schantz, Susan L., Schmidt, Rebecca J., Stanford, Joseph B., Straughen, Jennifer K., Stroustrup, Annemarie, Talge, Nicole M., Wright, Rosalind J., Zhao, Qi, and Leve, Leslie D.
- Published
- 2025
- Full Text
- View/download PDF
33. Garra ngopi sp. n., a new fish species (Cyprinidae: Labeoninae) from the Brahmaputra River basin, Arunachal Pradesh, North–Eastern India
- Author
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Tenali, Diamond Rajakumar, Chandran, Rejani, Singh, Rajeev K., and Sarkar, Uttam Kumar
- Published
- 2025
- Full Text
- View/download PDF
34. Correction to: Real‑World Evidence of the Safety and Effectiveness of Atogepant Added to OnabotulinumtoxinA for the Preventive Treatment of Chronic Migraine: A Retrospective Chart Review
- Author
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Blumenfeld, Andrew M., Mechtler, Laszlo, Cook, Lisa, Rhyne, Christopher, Jenkins, Brian, Hughes, Olivia, Dabruzzo, Brett, Manack Adams, Aubrey, and Diamond, Merle
- Published
- 2024
- Full Text
- View/download PDF
35. The Social Convergence of Information Disorder: Discovery and Analysis of the “Fertile Ground” of COVID-19 Vaccine Hesitancy
- Author
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Palen, Leysia, Rama Subramanian, Deepika, Diamond, Lindsay Levkoff, Batan, Hande, and Harris, Tajanae
- Published
- 2024
- Full Text
- View/download PDF
36. Evolution of myeloid-mediated immunotherapy resistance in prostate cancer
- Author
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Lyu, Aram, Fan, Zenghua, Clark, Matthew, Lea, Averey, Luong, Diamond, Setayesh, Ali, Starzinski, Alec, Wolters, Rachel, Arias-Badia, Marcel, Allaire, Kate, Wu, Kai, Gurunathan, Vibha, Valderrábano, Laura, Wei, Xiao X., Miller, Richard A., Van Allen, Eliezer M., and Fong, Lawrence
- Published
- 2024
- Full Text
- View/download PDF
37. Real-World Evidence of the Safety and Effectiveness of Atogepant Added to OnabotulinumtoxinA for the Preventive Treatment of Chronic Migraine: A Retrospective Chart Review
- Author
-
Blumenfeld, Andrew M., Mechtler, Laszlo, Cook, Lisa, Rhyne, Christopher, Jenkins, Brian, Hughes, Olivia, Dabruzzo, Brett, Manack Adams, Aubrey, and Diamond, Merle
- Published
- 2024
- Full Text
- View/download PDF
38. Genetic structure of Atlantic Puffins (Fratercula arctica) breeding in Atlantic Canada
- Author
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Carvey, Quinn B., Pavey, Scott A., Diamond, Antony W., Davoren, Gail K., Lavoie, Raphael A., LeBlanc, Nathalie M., Legard, Matthew J., Robertson, Gregory J., Runnells, Emily S., Petalas, Christina, and Major, Heather L.
- Published
- 2024
- Full Text
- View/download PDF
39. Fostering Scholarly Writing through the Division for Early Childhood Consortium for Innovations in Doctoral Excellence (DECIDE) Mentorship
- Author
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Macy, Marisa, Diamond, Lindsay, Riggleman, Samantha, McCorkle, Laura, and Zelan, Ali
- Published
- 2024
- Full Text
- View/download PDF
40. Diatom-based transfer functions for pH and total phosphorus in Vermont, USA lakes
- Author
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Biberovic, Ismar, Diamond, Sydney E., Heathcote, Adam J., Lini, Andrea, and Morales-Williams, Ana M.
- Published
- 2024
- Full Text
- View/download PDF
41. The effect of methylation on the let-7-BCL2L1-BCL2 axis and the potential use of hypomethylating and BH3 mimetic drugs in histiocytic neoplasms
- Author
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Salmon-Divon, Mali, Meyuchas, Refael, Shpilberg, Ofer, Okon, Elimelech, Benhamida, Jamal, Yabe, Mariko, Petrova-Drus, Kseniya, Zvida-Bloch, Tal, Basood, May, Mazor, Roei, Durham, Benjamin H., Haroche, Julien, Abdel-Wahab, Omar, Diamond, Eli L., and Hershkovitz-Rokah, Oshrat
- Published
- 2024
- Full Text
- View/download PDF
42. Optimization of the Irf8 +32-kb enhancer disrupts dendritic cell lineage segregation
- Author
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Ou, Feiya, Liu, Tian-Tian, Desai, Pritesh, Ferris, Stephen T., Kim, Sunkyung, Shen, Haolin, Ohara, Ray A., Jo, Suin, Chen, Jing, Postoak, J. Luke, Du, Siling, Diamond, Michael S., Murphy, Theresa L., and Murphy, Kenneth M.
- Published
- 2024
- Full Text
- View/download PDF
43. Rosai-Dorfman-Destombes disease in adults: a single center experience
- Author
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Leung, Emily, Pryma, Collin, Murphy, Stephen, Harrison, Rebecca, Peterson, Erica, Tsang, Peter W. K., Varghese, Julia, You, Xiaotian (Julie), Slack, Graham W., Skinnider, Brian F., Ng, Tony, Young, Sean, Burrell, Steven, Stubbins, Ryan, Lim, Howard, Carruthers, Mollie, Dutz, Jan, Diamond, Eli L., and Chen, Luke Y. C.
- Published
- 2024
- Full Text
- View/download PDF
44. Treatment Readiness in Psychiatric Residential Care for Adolescents
- Author
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Diamond, Guy, Ruan-Iu, Linda, Winston-Lindeboom, Payne, Rivers, Alannah Shelby, Weissinger, Guy, and Roeske, Michael
- Published
- 2024
- Full Text
- View/download PDF
45. B cells and generation of antibodies
- Author
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Atisha-Fregoso, Yemil, primary, Zou, Yong-Rui, additional, and Diamond, Betty, additional
- Published
- 2025
- Full Text
- View/download PDF
46. Optical Spectroscopy of Type Ia Supernovae by the Carnegie Supernova Projects I and II
- Author
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Morrell, N., Phillips, M. M., Folatelli, G., Stritzinger, M. D., Hamuy, M., Suntzeff, N. B., Hsiao, E. Y., Taddia, F., Burns, C. R., Hoeflich, P., Ashall, C., Contreras, C., Galbany, L., Lu, J., Piro, A. L., Anais, J., Baron, E., Burrow, A., Busta, L., Campillay, A., Castellón, S., Corco, C., Diamond, T., Freedman, W. L., González, C., Krisciunas, K., Kumar, S., Persson, S. E., Serón, J., Shahbandeh, M., Torres, S., Uddin, S. A., Anderson, J. P., Baltay, C., Gall, C., Goobar, A., Hadjiyska, E., Holmbo, S., Kasliwal, M., Lidman, C., Marion, G. H., Mazzali, P., Nugent, P., Perlmutter, S., Pignata, G., Rabinowitz, D., Roth, M., Ryder, S. D., Shappee, B. J., Vinkó, J., Wheeler, J. C., de Jaeger, T., Lira, P., Ruiz, M. T., Rich, J. A., Prieto, J. L., Di Mille, F., Osip, D., Blanc, G., and Palunas, P.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present the second and final release of optical spectroscopy of Type Ia Supernovae (SNe Ia) obtained during the first and second phases of the Carnegie Supernova Project (CSP-I and CSP-II). The newly released data consist of 148 spectra of 30 SNe Ia observed in the course of the CSP-I, and 234 spectra of 127 SNe Ia obtained during the CSP-II. We also present 216 optical spectra of 46 historical SNe Ia, including 53 spectra of 30 SNe Ia observed by the Cal\'an/Tololo Supernova Survey. We combine these observations with previously published CSP data and publicly-available spectra to compile a large sample of measurements of spectroscopic parameters at maximum light, consisting of pseudo-equivalent widths and expansion velocities of selected features, for 232 CSP and historical SNe Ia (including more than 1000 spectra). Finally, we review some of the strongest correlations between spectroscopic and photometric properties of SNe Ia. Specifically, we define two samples: one consisting of SNe Ia discovered by targeted searches (most of them CSP-I objects) and the other composed of SNe Ia discovered by untargeted searches, which includes most of the CSP-II objects. The analysed correlations are similar for both samples. We find a larger incidence of SNe Ia belonging to the Cool (CL)and Broad Line (BL) Branch subtypes among the events discovered by targeted searches, Shallow Silicon (SS) SNe Ia are present with similar frequencies in both samples, while Core Normal (CN) SNe Ia are more frequent in untargeted searches., Comment: 59 pages, 16 figures, accepted for publication in The Astrophysical Journal. May 7, 2024: LaTex file updated: corrected one missing comma and an extraneous space in Table 2
- Published
- 2024
47. Demonstration of weighted graph optimization on a Rydberg atom array using local light-shifts
- Author
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de Oliveira, A. G., Diamond-Hitchcock, E., Walker, D. M., Wells-Pestell, M. T., Pelegrí, G., Picken, C. J., Malcolm, G. P. A., Daley, A. J., Bass, J., and Pritchard, J. D.
- Subjects
Quantum Physics ,Physics - Atomic Physics - Abstract
Neutral atom arrays have emerged as a versatile platform towards scalable quantum computation and optimization. In this paper we present demonstrations of solving maximum weighted independent set problems on a Rydberg atom array using annealing with local light-shifts. We verify the ability to prepare weighted graphs in 1D and 2D arrays, including embedding a five vertex non-unit disk graph using nine physical qubits and demonstration of a simple crossing gadget. We find common annealing ramps leading to preparation of the target ground state robustly over a substantial range of different graph weightings. This work provides a route to exploring large-scale optimization of non-planar weighted graphs relevant for solving relevant real-world problems., Comment: 7 pages, 5 figures. Methods: 4 pages, 3 figures
- Published
- 2024
48. Improved Modelling of Detector Response Effects in Phonon-based Crystal Detectors used for Dark Matter Searches
- Author
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Wilson, M. J., Zaytsev, A., von Krosigk, B., Alkhatib, I., Buchanan, M., Chen, R., Diamond, M. D., Figueroa-Feliciano, E., Harms, S. A. S., Hong, Z., Kennard, K. T., Kurinsky, N. A., Mahapatra, R., Mirabolfathi, N., Novati, V., Platt, M., Ren, R., Sattari, A., Schmidt, B., Wang, Y., Zatschler, S., Zhang, E., and Zuniga, A.
- Subjects
Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
Various dark matter search experiments employ phonon-based crystal detectors operated at cryogenic temperatures. Some of these detectors, including certain silicon detectors used by the SuperCDMS Collaboration, are able to achieve single-charge sensitivity when a voltage bias is applied across the detector. The total amount of phonon energy measured by such a detector is proportional to the number of electron-hole pairs created by the interaction. However, crystal impurities and surface effects can cause propagating charges to either become trapped inside the crystal or create additional unpaired charges, producing non-quantized measured energy as a result. A new analytical model for describing these detector response effects in phonon-based crystal detectors is presented. This model improves upon previous versions by demonstrating how the detector response, and thus the measured energy spectrum, is expected to differ depending on the source of events. We use this model to extract detector response parameters for SuperCDMS HVeV detectors, and illustrate how this robust modelling can help statistically discriminate between sources of events in order to improve the sensitivity of dark matter search experiments., Comment: 19 pages, 7 figures
- Published
- 2024
- Full Text
- View/download PDF
49. Diabetes/ Endocrine Surveillance in SDS
- Author
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Shwachman Diamond Syndrome Foundation and Barnes-Jewish Hospital
- Published
- 2024
50. 3 Freedom from God: Rebalancing David Novak’s Covenantal Teology
- Author
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Diamond, James A., primary
- Published
- 2024
- Full Text
- View/download PDF
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