117,385 results on '"Diamond A"'
Search Results
2. Hot Rocks Survey I : A shallow eclipse for LHS 1478 b
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August, Prune C., Buchhave, Lars A., Diamond-Lowe, Hannah, Mendonça, João M., Gressier, Amélie, Rathcke, Alexander D., Allen, Natalie H., Fortune, Mark, Jones, Kathryn D., Meier-Valdés, Erik A., Demory, Brice-Olivier, Espinoza, Nestor, Fisher, Chloe E., Gibson, Neale P., Heng, Kevin, Hoeijmakers, Jens, Hooton, Matthew J., Kitzmann, Daniel, and Prinoth, Bibiana
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Astrophysics - Earth and Planetary Astrophysics - Abstract
M dwarf systems offer a unique opportunity to study terrestrial exoplanetary atmospheres due to their smaller size and cooler temperatures. However, due to the extreme conditions these host stars impose, it is unclear whether their small, close-in rocky planets are able to retain any atmosphere at all. The Hot Rocks Survey aims to answer this question by targeting nine different M dwarf rocky planets spanning a range of planetary and stellar properties. LHS 1478 b orbits an M3-type star, has an equilibrium temperature of Teq = 585 K and experiences an instellation 21 times greater than that of Earth. We observe two secondary eclipses using photometric imaging at 15 um using the Mid-Infrared Instrument on the James Webb Space Telescope (JWST MIRI) to measure thermal emission from the dayside of the planet. We then compare these values to different atmospheric scenarios to evaluate potential heat transport and CO2 absorption signatures. We find a secondary eclipse depth of 146 +/- 56 ppm based on the first observation, while the second observation results in a non-detection due to significantly larger unexplained systematics. Based on the first observation alone, we can reject the null hypothesis of the dark (zero Bond albedo) no atmosphere bare rock model with a confidence level of 3.4 sigma. For an airless body with a Bond albedo of A=0.2, the significance decreases to 2.9 sigma. The secondary eclipse depth is consistent with the majority of atmospheric scenarios we considered, which all involve atmospheres which include different concentrations of CO2, and surface pressures from 0.1 to 10 bar. However, we stress that the two observations from our program do not yield consistent results, and more observations are needed to verify our findings. The Hot Rocks Survey serves as a relevant primer for future endeavors such as the Director's Discretionary Time (DDT) Rocky Worlds program., Comment: Submitted to A&A
- Published
- 2024
3. The Thermal Emission Spectrum of the Nearby Rocky Exoplanet LTT 1445A b from JWST MIRI/LRS
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Wachiraphan, Patcharapol, Berta-Thompson, Zachory K., Diamond-Lowe, Hannah, Winters, Jennifer G., Murray, Catriona, Zhang, Michael, Xue, Qiao, Morley, Caroline V., Rosario-Franco, Marialis, and Duvvuri, Girish M.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The nearby transiting rocky exoplanet LTT 1445A b presents an ideal target for studying atmospheric retention in terrestrial planets orbiting M dwarfs. It is cooler than many rocky exoplanets yet tested for atmospheres, receiving a bolometric instellation similar to Mercury's. Previous transmission spectroscopy ruled out a light H/He-dominated atmosphere but could not distinguish between a bare-rock, a high-MMW, or a cloudy atmosphere. We present new secondary eclipse observations using JWST's MIRI/LRS, covering the 5-12 $\mu$m range. From these observations, we detect a broadband secondary eclipse depth of 41 $\pm$ 9 ppm and measure a mid-eclipse timing consistent with a circular orbit (at 1.7$\sigma$). From its emission spectrum, the planet's dayside brightness temperature is constrained to 525 $\pm$ 15 K, yielding a temperature ratio relative to the maximum average dayside temperature from instant thermal reradiation by a rocky surface $R$ = $T_{\rm day,obs}/T_{\rm max}$ = 0.952 $\pm$ 0.057, consistent with emission from a dark rocky surface. From an energy balance perspective, such a warm dayside temperature disfavors thick atmospheres, excluding $\sim$100 bar atmospheres with Bond albedo $>$ 0.08 at the 3$\sigma$ level. Furthermore, forward modeling of atmospheric emission spectra disfavor simple 100\% CO$_2$ atmospheres with surface pressures of 1, 10, and 100 bar at 4.2$\sigma$, 6.6$\sigma$, and 6.8$\sigma$ confidence, respectively. These results suggest that LTT 1445A b lacks a very thick CO$_2$ atmosphere, possibly due to atmospheric erosion driven by stellar activity. However, the presence of a moderately thin atmosphere (similar to those on Mars, Titan, or Earth) remains uncertain., Comment: 31 pages, 14 figures, submitted to AJ
- Published
- 2024
4. Formation of Jupiter-Mass Binary Objects through photoerosion of fragmenting cores
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Diamond, Jessica L. and Parker, Richard J.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The recent discovery of tens of Jupiter-mass binary objects (JuMBOs) in the Orion Nebula Cluster with the James Webb Space Telescope has intensified the debate on the origin of free-floating planetary mass objects within star-forming regions. The JuMBOs have masses below the opacity limit for fragmentation, but have very wide separations (10s - 100s au), suggesting that they did not form in a similar manner to other substellar mass binaries. Here, we propose that the theory of photoerosion of prestellar cores by Lyman continuum radiation from massive stars could explain the JuMBOs in the ONC. We find that for a range of gas densities the final substellar mass is comfortably within the JuMBO mass range, and that the separations of the JuMBOs are consistent with those of more massive (G- and A-type) binaries, that would have formed from the fragmentation of the cores had they not been photoeroded. The photoerosion mechanism is most effective within the HII region(s) driven by the massive star(s). The majority of the observed JuMBOs lie outside of these regions in the ONC, but may have formed within them and then subsequently migrated due to dynamical evolution., Comment: 9 pages, 4 figures, accepted for publication in ApJ
- Published
- 2024
5. Asymptotic Lower Bounds for the Feedback Arc Set Problem in Random Graphs
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Diamond, Harvey, Kon, Mark, and Raphael, Louise
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Mathematics - Combinatorics ,05C80 (Primary) 05C85, 68W40 (Secondary) - Abstract
Given a directed graph, the Minimal Feedback Arc Set (FAS) problem asks for a minimal set of arcs in a directed graph, which, when removed, results in an acyclic graph. Equivalently, the FAS problem asks to find an ordering of the vertices that minimizes the number of feedback arcs. This is considered an algorithmic problem of central importance in discrete mathematics, with varied applications to problems in computer science and operations research. Berger and Shor, in 1990, developed upper bounds for the FAS problem in general directed graphs. Here we find asymptotic lower bounds for the FAS problem in a class of random graphs given by the Erd\H{o}s-R\'{e}nyi model G(n,M), with n vertices and M (undirected) edges, the latter randomly chosen. Each edge is then randomly given a direction to form our directed graph. Our interest is in developing a $\textit{lower}$ bound for the minimal feedback arc set that holds with probability 1 as $n\rightarrow \infty$. We show that $$Pr\left(\textbf{Y}^* \le M \left( \frac{1}{2} -\sqrt{\frac{\log n}{2\Delta_{av}}}\right)\right)$$ approaches zero exponentially in $n$, with $\textbf{Y}^*$ the (random) size of the minimal feedback set and $\Delta_{av}=M/n$ the average vertex degree. We subsequently apply our lower bounds to a set of experimental FAS data on related random graphs, as developed by Kathrin Hanauer. Not only does our formula provide a reasonably close lower bound for the minimal set, but the approximation that lies midway between our lower bound and the obvious upper bound of $M/2$ is remarkably close to the computed FAS data over a range of experiments, suggesting that this approximation may in fact be asymptotic to the minimal number of feedback arcs, for large $n$, and an excellent estimate even for moderate values., Comment: 11 pages, 4 figures
- Published
- 2024
6. The Outflowing [OII] Nebulae of Compact Starburst Galaxies at z $\sim$ 0.5
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Perrotta, Serena, Coil, Alison L., Rupke, David S. N., Ning, Wenmeng, Duong, Brendan, Diamond-Stanic, Aleksandar M., Fielding, Drummond B., Geach, James E., Hickox, Ryan C., Moustakas, John, Rudnick, Gregory H., Sell, Paul H., Swiggum, Cameren N., and Tremonti, Christy A.
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Astrophysics - Astrophysics of Galaxies - Abstract
High-velocity outflows are ubiquitous in compact, massive (M$_* \sim$ 10$^{11}$ M$_{\odot}$), z $\sim$ 0.5 galaxies with extreme star formation surface densities ($\Sigma_{SFR} \sim$ 2000 M$_{\odot}$ yr$^{-1}$ kpc$^{-2}$). We have previously detected and characterized these outflows using MgII absorption lines. To probe their full extent, we present Keck/KCWI integral field spectroscopy of the [OII] and MgII emission nebulae surrounding all of the 12 galaxies in this study. We find that [OII] is more effective than MgII in tracing low surface brightness, extended emission in these galaxies. The [OII] nebulae are spatially extended beyond the stars, with radial extent R$_{90}$ between 10 and 40 kpc. The nebulae exhibit non-gravitational motions, indicating galactic outflows with maximum blueshifted velocities ranging from -335 to -1920 km s$^{-1}$. The outflow kinematics correlate with the bursty star formation histories of these galaxies. Galaxies with the most recent bursts of star formation (within the last $<$ 3 Myr) exhibit the highest central velocity dispersions ($\sigma >$ 400 km s$^{-1}$), while the oldest bursts have the lowest-velocity outflows. Many galaxies exhibit both high-velocity cores and more extended, slower-moving gas indicative of multiple outflow episodes. The slower, larger outflows occurred earlier and have decelerated as they propagate into the CGM and mix on timescales $>$ 50 Myr., Comment: Accepted for publication in The Astrophysical Journal
- Published
- 2024
7. Illuminating dark objects with dark matter lampshades
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Bramante, Joseph, Diamond, Melissa D., and Kim, J. Leo
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High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We demonstrate a new technique to search for dark compact objects. When dark matter comprising a dark compact object interacts with photons, the compact object can disperse light traveling though it. As these objects pass between the Earth and a distant star, they act as "lampshades" that dim the star. We examine how dimming effects from clumps of dark matter in the galaxy could be searched for in microlensing surveys, which measure the brightness of stars as a function of time. Using the EROS-2 and OGLE surveys, we show that a dimming analysis of existing data can be used to constrain dark sectors, and could be used to discover dark matter in compact objects., Comment: 12 pages, 6 figures
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- 2024
8. Migrating English Language Instruction from Face to Face to Online Learning
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Gwendolyn M. Williams, Hyeon-Jean Yoo, and Mary S. Diamond
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This paper describes a qualitative study that examined the lived experience of 50 English language instructors who transitioned from in-person teaching to online instruction during the COVID pandemic of 2020. The purpose of this study focused on the contrast between systematic online English language teacher preparation and rapid migration to identify strategies that can facilitate sudden shifts in instructional contexts. The data that was collected through snowball sampling with an anonymous Qualtrics survey revealed that during this rapid transition, instructors struggled with learning the technological pedagogy skills, establishing connections with their students, implementing assessment practices, and organizing student interactions. After a description of the findings, the article concludes with implications for teacher education for online English language instruction.
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- 2024
9. J-TEXT achievements in turbulence and transport in support of future device/reactor
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Zhipeng, CHEN, HUANG, Zhangsheng, JIANG, Min, Ting, LONG, Lu, WANG, Weixin, GUO, Zhoujun, YANG, Hai, LIU, Tao, LAN, Kaijun, ZHAO, Yuhong, XU, Rui, KE, Youwen, SUN, Hanhui, LI, Wen, HE, ZHUANG, Ge, Yuejiang, SHI, ZHONG, Wulyu, Yonghua, DING, LIANG, Yunfeng, Wenjing, TIAN, Xin, XU, ZHANG, Guodong, HUSSAIN, MS, and DIAMOND, Patrick H
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Nuclear and Plasma Physics ,Physical Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Fluids & Plasmas ,Nuclear and plasma physics - Abstract
Abstract: Following the reconstruction of the TEXT tokamak at Huazhong University of Science and Technology in China, renamed as J-TEXT, a plethora of experimental and theoretical investigations has been conducted to elucidate the intricacies of turbulent transport within the tokamak configuration. These endeavors encompass not only the J-TEXT device’s experimental advancements but also delve into critical issues pertinent to the optimization of future fusion devices and reactors. The research includes topics on the suppression of turbulence, flow drive and damping, density limit, non-local transport, intrinsic toroidal flow, turbulence and flow with magnetic islands, turbulent transport in the stochastic layer, and turbulence and zonal flow with energetic particles or helium ash. Several important achievements have been made in the last few years, which will be further elaborated upon in this comprehensive review.
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- 2024
10. Epics Deployment at Fermilab
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Hanlet, P., Gonzalez, M., Diamond, J., and Martin, K. S.
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Physics - Accelerator Physics - Abstract
Fermilab has traditionally not been an EPICS house; as such expertise in EPICS is limited and scattered. PIP-II will be using EPICS for its control system. When in operation, it will need to interface with the existing, modernized (see ACORN) legacy control system. Treating EPICS controls at Fermilab as a green field, we have developed and deployed a software pipeline which addresses these needs and presents to developers a tested and robust software framework, including template IOCs from which new developers can quickly deploy new front ends, aka IOCs. In this presentation, motivation for this work, implementation of a continuous integration/continuous deployment pipeline, testing, template IOCs, and the deployment of user services/applications will be discussed. This new infrastructure of IOCs and services is being developed and used in the PIP-II cryomodule teststand; our experiences and lessons learned will be also be discussed., Comment: 19th Biennial International Conference on Accelerator and Large Experimental Physics Control Systems (ICALEPCS 2023)
- Published
- 2024
11. Evaluating Large Language Models with fmeval
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Schwöbel, Pola, Franceschi, Luca, Zafar, Muhammad Bilal, Vasist, Keerthan, Malhotra, Aman, Shenhar, Tomer, Tailor, Pinal, Yilmaz, Pinar, Diamond, Michael, and Donini, Michele
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Computer Science - Computation and Language ,Computer Science - Machine Learning - Abstract
fmeval is an open source library to evaluate large language models (LLMs) in a range of tasks. It helps practitioners evaluate their model for task performance and along multiple responsible AI dimensions. This paper presents the library and exposes its underlying design principles: simplicity, coverage, extensibility and performance. We then present how these were implemented in the scientific and engineering choices taken when developing fmeval. A case study demonstrates a typical use case for the library: picking a suitable model for a question answering task. We close by discussing limitations and further work in the development of the library. fmeval can be found at https://github.com/aws/fmeval.
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- 2024
12. Light Dark Matter Constraints from SuperCDMS HVeV Detectors Operated Underground with an Anticoincidence Event Selection
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SuperCDMS Collaboration, Albakry, M. F., Alkhatib, I., Alonso-González, D., Amaral, D. W. P., Anczarski, J., Aralis, T., Aramaki, T., Arnquist, I. J., Langroudy, I. Ataee, Azadbakht, E., Bathurst, C., Bhattacharyya, R., Biffl, A. J., Brink, P. L., Buchanan, M., Bunker, R., Cabrera, B., Calkins, R., Cameron, R. A., Cartaro, C., Cerdeño, D. G., Chang, Y. -Y., Chaudhuri, M., Chen, J. -H., Chen, R., Chott, N., Cooley, J., Coombes, H., Cushman, P., Cyna, R., Das, S., De Brienne, F., Dharani, S., di Vacri, M. L., Diamond, M. D., Elwan, M., Fascione, E., Figueroa-Feliciano, E., Fouts, K., Fritts, M., Germond, R., Ghaith, M., Golwala, S. R., Hall, J., Harms, S. A. S., Harris, K., Hassan, N., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jardin, D., Kashyap, V. K. S., Keller, S. T. D., Kelsey, M. H., Kennard, K. T., Kubik, A., Kurinsky, N. A., Lee, M., Leyva, J., Liu, J., Liu, Y., Loer, B., Asamar, E. Lopez, Lukens, P., MacFarlane, D. B., Mahapatra, R., Mammo, J. S., Mast, N., Mayer, A. J., Theenhausen, H. Meyer zu, Michaud, É., Michielin, E., Mirabolfathi, N., Mirzakhani, M., Mohanty, B., Monteiro, D., Nelson, J., Neog, H., Novati, V., Orrell, J. L., Osborne, M. D., Oser, S. M., Pandey, L., Pandey, S., Partridge, R., Pedreros, D. S., Peng, W., Perna, L., Perry, W. L., Podviianiuk, R., Poudel, S. S., Pradeep, A., Pyle, M., Rau, W., Reid, E., Ren, R., Reynolds, T., Rios, M., Roberts, A., Robinson, A. E., Ryan, J. L., Saab, T., Sadek, D., Sadoulet, B., Sahoo, S. P., Saikia, I., Sander, J., Sattari, A., Schmidt, B., Schnee, R. W., Scorza, S., Serfass, B., Simchony, A., Sincavage, D. J., Sinervo, P., Street, J., Sun, H., Tanner, E., Terry, G. D., Toback, D., Verma, S., Villano, A. N., von Krosigk, B., Watkins, S. L., Wen, O., Williams, Z., Wilson, M. J., Winchell, J., Wykoff, K., Yellin, S., Young, B. A., Yu, T. C., Zatschler, B., Zatschler, S., Zaytsev, A., Zhang, E., Zheng, L., Zuniga, A., and Zurowski, M. J.
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High Energy Physics - Experiment ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Physics - Instrumentation and Detectors - Abstract
This article presents constraints on dark-matter-electron interactions obtained from the first underground data-taking campaign with multiple SuperCDMS HVeV detectors operated in the same housing. An exposure of 7.63 g-days is used to set upper limits on the dark-matter-electron scattering cross section for dark matter masses between 0.5 and 1000 MeV/$c^2$, as well as upper limits on dark photon kinetic mixing and axion-like particle axioelectric coupling for masses between 1.2 and 23.3 eV/$c^2$. Compared to an earlier HVeV search, sensitivity was improved as a result of an increased overburden of 225 meters of water equivalent, an anticoincidence event selection, and better pile-up rejection. In the case of dark-matter-electron scattering via a heavy mediator, an improvement by up to a factor of 25 in cross-section sensitivity was achieved., Comment: 7 pages + title and references, 4 figures, and 1 table
- Published
- 2024
13. TreeSeg: Hierarchical Topic Segmentation of Large Transcripts
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Gklezakos, Dimitrios C., Misiak, Timothy, and Bishop, Diamond
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Computer Science - Computation and Language - Abstract
From organizing recorded videos and meetings into chapters, to breaking down large inputs in order to fit them into the context window of commoditized Large Language Models (LLMs), topic segmentation of large transcripts emerges as a task of increasing significance. Still, accurate segmentation presents many challenges, including (a) the noisy nature of the Automatic Speech Recognition (ASR) software typically used to obtain the transcripts, (b) the lack of diverse labeled data and (c) the difficulty in pin-pointing the ground-truth number of segments. In this work we present TreeSeg, an approach that combines off-the-shelf embedding models with divisive clustering, to generate hierarchical, structured segmentations of transcripts in the form of binary trees. Our approach is robust to noise and can handle large transcripts efficiently. We evaluate TreeSeg on the ICSI and AMI corpora, demonstrating that it outperforms all baselines. Finally, we introduce TinyRec, a small-scale corpus of manually annotated transcripts, obtained from self-recorded video sessions.
- Published
- 2024
14. High-energy spectra of LTT 1445A and GJ 486 reveal flares and activity
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Diamond-Lowe, H., King, G. W., Youngblood, A., Brown, A., Howard, W. S., Winters, J. G., Wilson, D. J., France, K., Mendonça, J. M., Buchhave, L. A., Corrales, L., Kreidberg, L., Medina, A. A., Bean, J. L., Berta-Thompson, Z. K., Evans-Soma, T. M., Froning, C., Duvvuri, G. M., Kempton, E. M. -R., Miguel, Y., Pineda, J. S., and Schneider, C.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The high-energy radiative output, from the X-ray to the ultraviolet, of exoplanet host stars drives photochemical reactions and mass loss in the upper regions of planetary atmospheres. In order to place constraints on the atmospheric properties of the three closest terrestrial exoplanets transiting M dwarfs, we observe the high-energy spectra of the host stars LTT1445A and GJ486 in the X-ray with XMM-Newton and Chandra and in the ultraviolet with HST/COS and STIS. We combine these observations with estimates of extreme ultraviolet flux, reconstructions of the Ly-a lines, and stellar models at optical and infrared wavelengths to produce panchromatic spectra from 1A--20um for each star. While LTT1445Ab, LTT1445Ac, and GJ486b do not possess primordial hydrogen-dominated atmospheres, we calculate that they are able to retain pure CO2 atmospheres if starting with 10, 15, and 50% of Earth's total CO2 budget, respectively, in the presence of their host stars' stellar wind. We use age-activity relationships to place lower limits of 2.2 and 6.6 Gyr on the ages of the host stars LTT1445A and GJ486. Despite both LTT1445A and GJ486 appearing inactive at optical wavelengths, we detect flares at ultraviolet and X-ray wavelengths for both stars. In particular, GJ486 exhibits two flares with absolute energies of 10^29.5 and 10^30.1 erg (equivalent durations of 4357+/-96 and 19724+/-169 s) occurring three hours apart, captured with HST/COS G130M. Based on the timing of the observations, we suggest that these high-energy flares are related and indicative of heightened flaring activity that lasts for a period of days, but our interpretations are limited by sparse time-sampling. Consistent high-energy monitoring is needed to determine the duration and extent of high-energy activity on individual M dwarfs, as well as the population as a whole., Comment: 21 pages, published in A&A
- Published
- 2024
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15. Renewing the Case for Regionalism: EU Transnational Governance in an Era of Regulatory Nationalism
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Diamond Ashiagbor
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Law of Europe ,KJ-KKZ ,Law in general. Comparative and uniform law. Jurisprudence ,K1-7720 - Published
- 2020
- Full Text
- View/download PDF
16. Density fluctuation statistics and turbulence spreading at the edge of L-mode plasmas
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Khabanov, Filipp, Hong, Rongjie, Diamond, Patrick H, Tynan, George R, Yan, Z, McKee, George R, Chrystal, Colin, Scotti, Filippo, Yu, Guanying, Zamperini, Shawn Angelo, and Zhu, Yilun
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Nuclear and Plasma Physics ,Physical Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Fluids & Plasmas ,Nuclear and plasma physics - Abstract
Abstract: Long-wavelength density fluctuations ( k ρ i 0.97, indicating the prevalence of density ‘voids’ at inner radii and density ‘blobs’ at outer radii and outside of the separatrix. The turbulence intensity flux ⟨ v ~ r n ~ 2 ⟩ is calculated to characterize turbulence spreading at the plasma edge. During ECH/NBI power ramps and at counter- I p injected torque, ⟨ v ~ r n ~ 2 ⟩ is directed inward inside the separatrix, which is evidence of inward spreading of turbulence intensity from the edge gradient region caused by the inner propagation of density ‘voids’. Significantly weaker ⟨ v ~ r n ~ 2 ⟩ is observed with co- I p torque. A correlation between co- I p torque, turbulence intensity δ n / n at ρ = 0.97, and increased srape-off layer (SOL) heat flux decay length λ q is found in the torque scan scenario, showing that edge turbulence plays a material role in determining the SOL conditions and heat flux width.
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- 2024
17. Has Reducing Ship Emissions Brought Forward Global Warming?
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Gettelman, A, Christensen, MW, Diamond, MS, Gryspeerdt, E, Manshausen, P, Stier, P, Watson‐Parris, D, Yang, M, Yoshioka, M, and Yuan, T
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Earth Sciences ,Atmospheric Sciences ,Climate Action ,climate ,aerosols ,sulfur ,global warming ,Meteorology & Atmospheric Sciences - Abstract
Abstract: Ships brighten low marine clouds from emissions of sulfur and aerosols, resulting in visible “ship tracks”. In 2020, new shipping regulations mandated an ∼80% reduction in the allowed fuel sulfur content. Recent observations indicate that visible ship tracks have decreased. Model simulations indicate that since 2020 shipping regulations have induced a net radiative forcing of +0.12 Wm−2. Analysis of recent temperature anomalies indicates Northern Hemisphere surface temperature anomalies in 2022–2023 are correlated with observed cloud radiative forcing and the cloud radiative forcing is spatially correlated with the simulated radiative forcing from the 2020 shipping emission changes. Shipping emissions changes could be accelerating global warming. To better constrain these estimates, better access to ship position data and understanding of ship aerosol emissions are needed. Understanding the risks and benefits of emissions reductions and the difficultly in robust attribution highlights the large uncertainty in attributing proposed deliberate climate intervention.
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- 2024
18. Desiccated Cyanobacteria Serve As Efficient Plasmid DNA Carriers in Space Flight.
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Kakouridis, Anne, Diamond, Spencer, Eng, Thomas, Mills, Heath J, Gámez Holzhaus, Olivia, Summers, Michael L, Garcia-Pichel, Ferran, and Mukhopadhyay, Aindrila
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Biological Sciences ,Industrial Biotechnology ,Genetics ,Cyanobacteria ,InternationalSpace Station ,Nostoc punctiforme ,Space Flight ,Space Travel ,International Space Station ,Medicinal and Biomolecular Chemistry ,Biochemistry and Cell Biology ,Biomedical Engineering ,Biochemistry and cell biology ,Bioinformatics and computational biology - Abstract
Effective transport of biological systems as cargo during space travel is a critical requirement to use synthetic biology and biomanufacturing in outer space. Bioproduction using microbes will drive the extent to which many human needs can be met in environments with limited resources. Vast repositories of biological parts and strains are available to meet this need, but their on-site availability requires effective transport. Here, we explore an approach that allows DNA plasmids, ubiquitous synthetic biology parts, to be safely transported to the International Space Station and back to the Kennedy Space Center without low-temperature or cryogenic stowage. Our approach relied on the cyanobacterium Nostoc punctiforme PC73102, which is naturally tolerant to prolonged desiccation. Desiccated N. punctiforme was able to carry the non-native pSCR119 plasmid as intracellular cargo safely to space and back. Upon return to the laboratory, the extracted plasmid showed no DNA damage or additional mutations and could be used as intended to transform the model synbio host Escherichia coli to bestow kanamycin resistance. This proof-of-concept study provides the foundation for a ruggedized transport host for DNA to environments where there is a need to reduce equipment and infrastructure for biological parts stowage and storage.
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- 2024
19. Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells.
- Author
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Torres-Velarde, Julia, Allen, Kaitlin, Salvador-Pascual, Andrea, Leija, Roberto, Luong, Diamond, Moreno-Santillán, Diana, Ensminger, David, and Vázquez-Medina, José
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14-3-3ε ,Cell death ,GPx4 ,Integrated stress response ,Mitochondria ,TP53 ,aiPLA(2) ,Ferroptosis ,Peroxiredoxin VI ,Phospholipid Hydroperoxide Glutathione Peroxidase ,Lung ,Animals ,Endothelial Cells ,Mice ,Lipid Peroxidation ,Humans ,Phospholipases A2 ,Mice ,Knockout ,Piperazines ,Group VI Phospholipases A2 - Abstract
Peroxiredoxin 6 (Prdx6) repairs peroxidized membranes by reducing oxidized phospholipids, and by replacing oxidized sn-2 fatty acyl groups through hydrolysis/reacylation by its phospholipase A2 (aiPLA2) and lysophosphatidylcholine acyltransferase activities. Prdx6 is highly expressed in the lung, and intact lungs and cells null for Prdx6 or with single-point mutations that inactivate either Prdx6-peroxidase or aiPLA2 activity alone exhibit decreased viability, increased lipid peroxidation, and incomplete repair when exposed to paraquat, hyperoxia, or organic peroxides. Ferroptosis is form of cell death driven by the accumulation of phospholipid hydroperoxides. We studied the role of Prdx6 as a ferroptosis suppressor in the lung. We first compared the expression Prdx6 and glutathione peroxidase 4 (GPx4) and visualized Prdx6 and GPx4 within the lung. Lung Prdx6 mRNA levels were five times higher than GPx4 levels. Both Prdx6 and GPx4 localized to epithelial and endothelial cells. Prdx6 knockout or knockdown sensitized lung endothelial cells to erastin-induced ferroptosis. Cells with genetic inactivation of either aiPLA2 or Prdx6-peroxidase were more sensitive to ferroptosis than WT cells, but less sensitive than KO cells. We then conducted RNA-seq analyses in Prdx6-depleted cells to further explore how the loss of Prdx6 sensitizes lung endothelial cells to ferroptosis. Prdx6 KD upregulated transcriptional signatures associated with selenoamino acid metabolism and mitochondrial function. Accordingly, Prdx6 deficiency blunted mitochondrial function and increased GPx4 abundance whereas GPx4 KD had the opposite effect on Prdx6. Moreover, we detected Prdx6 and GPx4 interactions in intact cells, suggesting that both enzymes cooperate to suppress lipid peroxidation. Notably, Prdx6-depleted cells remained sensitive to erastin-induced ferroptosis despite the compensatory increase in GPx4. These results show that Prdx6 suppresses ferroptosis in lung endothelial cells and that both aiPLA2 and Prdx6-peroxidase contribute to this effect. These results also show that Prdx6 supports mitochondrial function and modulates several coordinated cytoprotective pathways in the pulmonary endothelium.
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- 2024
20. The role of shear flow collapse and enhanced turbulence spreading in edge cooling approaching the density limit
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Long, Ting, Diamond, PH, Ke, Rui, Chen, Zhipeng, Xu, Xin, Tian, Wenjing, Hong, Rongjie, Cao, Mingyun, Liu, Yanmin, Xu, Min, Wang, Lu, Yang, Zhoujun, Yuan, Jinbang, Zhou, Yongkang, Yan, Qinghao, Yang, Qinghu, Shen, Chengshuo, Nie, Lin, Wang, Zhanhui, Hao, Guangzhou, Wang, Nengchao, Chen, Zhongyong, Li, Jiquan, Chen, Wei, and Zhong, Wulyu
- Subjects
Nuclear and Plasma Physics ,Physical Sciences ,tokamak ,density limit ,edge cooling ,turbulence spreading ,shear flow ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Fluids & Plasmas ,Nuclear and plasma physics - Abstract
Experimental studies of the dynamics of shear flow and turbulence spreading at the edge of tokamak plasmas are reported. Scans of line-averaged density and plasma current are carried out while approaching the Greenwald density limit on the J-TEXT tokamak. In all scans, when the Greenwald fraction f G = n ¯ / n G = n ¯ / ( I p / π a 2 ) increases, a common feature of enhanced turbulence spreading and edge cooling is found. The result suggests that turbulence spreading is a good indicator of edge cooling, indeed better than turbulent particle transport is. The normalized turbulence spreading power increases significantly when the normalized E × B shearing rate decreases. This indicates that turbulence spreading becomes prominent when the shearing rate is weaker than the turbulence scattering rate. The asymmetry between positive/negative (blobs/holes) spreading events, turbulence spreading power and shear flow are discussed. These results elucidate the important effects of interaction between shear flow and turbulence spreading on plasma edge cooling.
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- 2024
21. Dissipative Dark Cosmology: From Early Matter Dominance to Delayed Compact Objects
- Author
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Bramante, Joseph, Cappiello, Christopher V., Diamond, Melissa D., Kim, J. Leo, Liu, Qinrui, and Vincent, Aaron C.
- Subjects
High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We demonstrate a novel mechanism for producing dark compact objects and black holes through a dark sector, where all the dark matter can be dissipative. Heavy dark sector particles with masses above $10^4$ GeV can come to dominate the Universe and yield an early matter-dominated era before Big Bang Nucleosynthesis (BBN). Density perturbations in this epoch can grow and collapse into tiny dark matter halos, which cool via self interactions. The typical halo size is set by the Hubble length once perturbations begin growing, offering a straightforward prediction of the halo size and evolution depending on ones choice of dark matter model. Once these primordial halos have formed, a thermal phase transition can then shift the Universe back into radiation domination and standard cosmology. These halos can continue to collapse after BBN, resulting in the late-time formation of fragmented dark compact objects and sub-solar mass primordial black holes. We find that these compact objects can constitute a sizable fraction of all of dark matter. The resulting fragments can have masses between $10^{20}$ g to $10^{32}$ g, with radii ranging from $10^{-2}$ m to $10^5$ m, while the black holes can have masses between $10^{8}$ g to $10^{34}$ g. Furthermore, a unique feature of this model is the late-time formation of black holes which can evaporate today. We compare where these objects lie with respect to current primordial black hole and and massive (astrophysical) compact halo object constraints., Comment: 12 pages, 6 figures. Accepted version
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- 2024
- Full Text
- View/download PDF
22. Optical Spectroscopy of Type Ia Supernovae by the Carnegie Supernova Projects I and II
- Author
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Morrell, N., Phillips, M. M., Folatelli, G., Stritzinger, M. D., Hamuy, M., Suntzeff, N. B., Hsiao, E. Y., Taddia, F., Burns, C. R., Hoeflich, P., Ashall, C., Contreras, C., Galbany, L., Lu, J., Piro, A. L., Anais, J., Baron, E., Burrow, A., Busta, L., Campillay, A., Castellón, S., Corco, C., Diamond, T., Freedman, W. L., González, C., Krisciunas, K., Kumar, S., Persson, S. E., Serón, J., Shahbandeh, M., Torres, S., Uddin, S. A., Anderson, J. P., Baltay, C., Gall, C., Goobar, A., Hadjiyska, E., Holmbo, S., Kasliwal, M., Lidman, C., Marion, G. H., Mazzali, P., Nugent, P., Perlmutter, S., Pignata, G., Rabinowitz, D., Roth, M., Ryder, S. D., Shappee, B. J., Vinkó, J., Wheeler, J. C., de Jaeger, T., Lira, P., Ruiz, M. T., Rich, J. A., Prieto, J. L., Di Mille, F., Osip, D., Blanc, G., and Palunas, P.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present the second and final release of optical spectroscopy of Type Ia Supernovae (SNe Ia) obtained during the first and second phases of the Carnegie Supernova Project (CSP-I and CSP-II). The newly released data consist of 148 spectra of 30 SNe Ia observed in the course of the CSP-I, and 234 spectra of 127 SNe Ia obtained during the CSP-II. We also present 216 optical spectra of 46 historical SNe Ia, including 53 spectra of 30 SNe Ia observed by the Cal\'an/Tololo Supernova Survey. We combine these observations with previously published CSP data and publicly-available spectra to compile a large sample of measurements of spectroscopic parameters at maximum light, consisting of pseudo-equivalent widths and expansion velocities of selected features, for 232 CSP and historical SNe Ia (including more than 1000 spectra). Finally, we review some of the strongest correlations between spectroscopic and photometric properties of SNe Ia. Specifically, we define two samples: one consisting of SNe Ia discovered by targeted searches (most of them CSP-I objects) and the other composed of SNe Ia discovered by untargeted searches, which includes most of the CSP-II objects. The analysed correlations are similar for both samples. We find a larger incidence of SNe Ia belonging to the Cool (CL)and Broad Line (BL) Branch subtypes among the events discovered by targeted searches, Shallow Silicon (SS) SNe Ia are present with similar frequencies in both samples, while Core Normal (CN) SNe Ia are more frequent in untargeted searches., Comment: 59 pages, 16 figures, accepted for publication in The Astrophysical Journal. May 7, 2024: LaTex file updated: corrected one missing comma and an extraneous space in Table 2
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- 2024
23. Demonstration of weighted graph optimization on a Rydberg atom array using local light-shifts
- Author
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de Oliveira, A. G., Diamond-Hitchcock, E., Walker, D. M., Wells-Pestell, M. T., Pelegrí, G., Picken, C. J., Malcolm, G. P. A., Daley, A. J., Bass, J., and Pritchard, J. D.
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Quantum Physics ,Physics - Atomic Physics - Abstract
Neutral atom arrays have emerged as a versatile platform towards scalable quantum computation and optimization. In this paper we present first demonstrations of weighted graph optimization on a Rydberg atom array using annealing with local light-shifts. We verify the ability to prepare weighted graphs in 1D and 2D arrays, including embedding a five vertex non-unit disk graph using nine physical qubits and demonstration of a simple crossing gadget. We find common annealing ramps leading to preparation of the target ground state robustly over a substantial range of different graph weightings. This work provides a route to exploring large-scale optimization of non-planar weighted graphs relevant for solving relevant real-world problems., Comment: 7 pages, 5 figures. Methods: 3 pages, 2 figures
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- 2024
24. Improved Modelling of Detector Response Effects in Phonon-based Crystal Detectors used for Dark Matter Searches
- Author
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Wilson, M. J., Zaytsev, A., von Krosigk, B., Alkhatib, I., Buchanan, M., Chen, R., Diamond, M. D., Figueroa-Feliciano, E., Harms, S. A. S., Hong, Z., Kennard, K. T., Kurinsky, N. A., Mahapatra, R., Mirabolfathi, N., Novati, V., Platt, M., Ren, R., Sattari, A., Schmidt, B., Wang, Y., Zatschler, S., Zhang, E., and Zuniga, A.
- Subjects
Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
Various dark matter search experiments employ phonon-based crystal detectors operated at cryogenic temperatures. Some of these detectors, including certain silicon detectors used by the SuperCDMS Collaboration, are able to achieve single-charge sensitivity when a voltage bias is applied across the detector. The total amount of phonon energy measured by such a detector is proportional to the number of electron-hole pairs created by the interaction. However, crystal impurities and surface effects can cause propagating charges to either become trapped inside the crystal or create additional unpaired charges, producing non-quantized measured energy as a result. A new analytical model for describing these detector response effects in phonon-based crystal detectors is presented. This model improves upon previous versions by demonstrating how the detector response, and thus the measured energy spectrum, is expected to differ depending on the source of events. We use this model to extract detector response parameters for SuperCDMS HVeV detectors, and illustrate how this robust modelling can help statistically discriminate between sources of events in order to improve the sensitivity of dark matter search experiments., Comment: 19 pages, 7 figures
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- 2024
- Full Text
- View/download PDF
25. The effect of methylation on the let-7-BCL2L1-BCL2 axis and the potential use of hypomethylating and BH3 mimetic drugs in histiocytic neoplasms
- Author
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Salmon-Divon, Mali, Meyuchas, Refael, Shpilberg, Ofer, Okon, Elimelech, Benhamida, Jamal, Yabe, Mariko, Petrova-Drus, Kseniya, Zvida-Bloch, Tal, Basood, May, Mazor, Roei, Durham, Benjamin H., Haroche, Julien, Abdel-Wahab, Omar, Diamond, Eli L., and Hershkovitz-Rokah, Oshrat
- Published
- 2024
- Full Text
- View/download PDF
26. Optimization of the Irf8 +32-kb enhancer disrupts dendritic cell lineage segregation
- Author
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Ou, Feiya, Liu, Tian-Tian, Desai, Pritesh, Ferris, Stephen T., Kim, Sunkyung, Shen, Haolin, Ohara, Ray A., Jo, Suin, Chen, Jing, Postoak, J. Luke, Du, Siling, Diamond, Michael S., Murphy, Theresa L., and Murphy, Kenneth M.
- Published
- 2024
- Full Text
- View/download PDF
27. Rosai-Dorfman-Destombes disease in adults: a single center experience
- Author
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Leung, Emily, Pryma, Collin, Murphy, Stephen, Harrison, Rebecca, Peterson, Erica, Tsang, Peter W. K., Varghese, Julia, You, Xiaotian (Julie), Slack, Graham W., Skinnider, Brian F., Ng, Tony, Young, Sean, Burrell, Steven, Stubbins, Ryan, Lim, Howard, Carruthers, Mollie, Dutz, Jan, Diamond, Eli L., and Chen, Luke Y. C.
- Published
- 2024
- Full Text
- View/download PDF
28. Treatment Readiness in Psychiatric Residential Care for Adolescents
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Diamond, Guy, Ruan-Iu, Linda, Winston-Lindeboom, Payne, Rivers, Alannah Shelby, Weissinger, Guy, and Roeske, Michael
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- 2024
- Full Text
- View/download PDF
29. Clinical trial knowledge among cancer survivors in the United States: the role of health information technology
- Author
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Akhiwu, Ted O., Adewunmi, Comfort, Bilalaga, Mariah, Atarere, Joseph O., Gaddipati, Greeshma, Chido-Amajuoyi, Onyema G., Eziuche, Diamond K., Onyeaka, Henry, and Amonoo, Hermioni L.
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- 2024
- Full Text
- View/download PDF
30. Mucosal adenovirus vaccine boosting elicits IgA and durably prevents XBB.1.16 infection in nonhuman primates
- Author
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Gagne, Matthew, Flynn, Barbara J., Andrew, Shayne F., Marquez, Josue, Flebbe, Dillon R., Mychalowych, Anna, Lamb, Evan, Davis-Gardner, Meredith E., Burnett, Matthew R., Serebryannyy, Leonid A., Lin, Bob C., Ziff, Zohar E., Maule, Erin, Carroll, Robin, Naisan, Mursal, Jethmalani, Yogita, Pessaint, Laurent, Todd, John-Paul M., Doria-Rose, Nicole A., Case, James Brett, Dmitriev, Igor P., Kashentseva, Elena A., Ying, Baoling, Dodson, Alan, Kouneski, Katelyn, O’Dell, Sijy, Wali, Bushra, Ellis, Madison, Godbole, Sucheta, Laboune, Farida, Henry, Amy R., Teng, I-Ting, Wang, Danyi, Wang, Lingshu, Zhou, Qiong, Zouantchangadou, Serge, Van Ry, Alex, Lewis, Mark G., Andersen, Hanne, Kwong, Peter D., Curiel, David T., Roederer, Mario, Nason, Martha C., Foulds, Kathryn E., Suthar, Mehul S., Diamond, Michael S., Douek, Daniel C., and Seder, Robert A.
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- 2024
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31. Moves & Rules: Addressing the Puzzle of Social Rule-Following
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Diamond, Alma
- Published
- 2024
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- View/download PDF
32. Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement
- Author
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Lee, Brian P., Witkiewitz, Katie, Mellinger, Jessica, Anania, Frank A., Bataller, Ramon, Cotter, Thomas G., Curtis, Brenda, Dasarathy, Srinivasan, DeMartini, Kelly S., Diamond, Ivan, Diazgranados, Nancy, DiMartini, Andrea F., Falk, Daniel E., Fernandez, Anne C., German, Margarita N., Kamath, Patrick S., Kidwell, Kelley M., Leggio, Lorenzo, Litten, Raye, Louvet, Alexandre, Lucey, Michael R., McCaul, Mary E., Sanyal, Arun J., Singal, Ashwani K., Sussman, Norman L., Terrault, Norah A., Thursz, Mark R., Verna, Elizabeth C., Radaeva, Svetlana, Nagy, Laura E., and Mitchell, Mack C.
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- 2024
- Full Text
- View/download PDF
33. Attachment-based family therapy, ter verbetering van het gezinsfunctioneren bij problemen tijdens de adolescentie met eetstoornissen in het eetbuispectrum: een eerste evaluatie door middel van een casusreeks
- Author
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Manasse, Stephanie M., Russon, Jody, Lampe, Elizabeth W., King, Allie, Abber, Sophie R., Trainor, Claire, Gillikin, Lindsay M., Levy, Suzanne, and Diamond, Guy
- Published
- 2024
- Full Text
- View/download PDF
34. Cultural Socialization and Civic Engagement Among Racially Diverse Students of Color: Examining Ethnic-Racial Identity Components as Mediators and Neighborhood Racial Composition as a Moderator
- Author
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Santana, Arlenis, Williams, Chelsea Derlan, Ahmed, Mehak, Romero, Mariela, Elias, Maria J., Walker, Chloe J., Moreno, Oswaldo, Lozada, Fantasy, Dick, Danielle M., and Bravo, Diamond Y.
- Published
- 2024
- Full Text
- View/download PDF
35. Competency Guidelines for Family Collaboration in Behavioral Health Services for Adolescents
- Author
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Bobek, Molly, Hogue, Aaron, Daleiden, Eric, MacLean, Alexandra, Porter, Nicole, Cela, Toni, Marcellin, Louis Herns, Diamond, Guy, and Donohue, Bradley
- Published
- 2024
- Full Text
- View/download PDF
36. Leading Through Climate Disasters and Environmental Injustice: Past, Present, and Future
- Author
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Griffard, Megan Rauch, author, Ebanks, Diamond, author, and Skousen, Jacob D., author
- Published
- 2024
- Full Text
- View/download PDF
37. Texas Takes on Transfer Grants: Interim Impacts of the Texas Transfer Grant Pilot Program on Student Transfer
- Author
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MDRC, Diamond, John, O'Donoghue, Rebekah, Alonzo, Erick, and Barman, Sukanya
- Abstract
Transferring to a four-year institution is an important pathway to student success. Many students who enroll in community college intend to transfer to a four-year institution and subsequently earn a bachelor's degree. However, few students ultimately do, with low-income students transferring at lower rates than their peers. The Texas Transfer Grant Pilot Program was created by the Texas Higher Education Coordinating Board (THECB) to improve the transfer rates of students from two-year to four-year institutions in Texas. The pilot program offered $5,000 grants to community college students who performed well academically, came from low-income backgrounds, and transferred to a public four-year institution. MDRC's evaluation of the program, conducted in partnership with the THECB, used Texas statewide administrative data to identify and randomly assign about 90,000 eligible students. Students were assigned to either a program group (whose members were notified they were eligible to receive the grant for the fall 2022 semester) or a control group (whose members did not receive a Texas Transfer Grant offer but who could seek business-as-usual financial aid resources). Students assigned to the program group were informed of the opportunity to receive a grant via email and hard-copy letters. This brief answers the following two primary questions: (1) Does offering the Texas Transfer Grant to community college students affect their enrollment rates at four-year higher education institutions in Texas? and (2) What do community college students think--and how do they feel--about the Texas Transfer Grant offer, particularly with respect to their decision to transfer to a four-year institution? Although additional research is needed to fully understand the impact of the grant offer, early findings indicate that the pilot program increased the proportion of students who enrolled in Texas public four-year institutions. [For the supplement, "Differential Impacts on Fall 2022 Enrollment at Any Four-Year Institution. A Supplement to Texas Takes on Transfer Grants," see ED627376.]
- Published
- 2023
38. Differential Impacts on Fall 2022 Enrollment at Any Four-Year Institution. A Supplement to 'Texas Takes on Transfer Grants'
- Author
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MDRC, Diamond, John, O'Donoghue, Rebekah, Alonzo, Erick, and Barman, Sukanya
- Abstract
This is the supplement to the report, "Texas Takes on Transfer Grants: Interim Impacts of the Texas Transfer Grant Pilot Program on Student Transfer." The Texas Transfer Grant Pilot Program was created by the Texas Higher Education Coordinating Board (THECB) to improve the transfer rates of students from two-year to four-year institutions in Texas. The pilot program offered $5,000 grants to community college students who performed well academically, came from low-income backgrounds, and transferred to a public four-year institution. MDRC's evaluation of the program, conducted in partnership with the THECB, used Texas statewide administrative data to identify and randomly assign about 90,000 eligible students. Students were assigned to either a program group (whose members were notified they were eligible to receive the grant for the fall 2022 semester) or a control group (whose members did not receive a Texas Transfer Grant offer but who could seek business-as-usual financial aid resources). Students assigned to the program group were informed of the opportunity to receive a grant via email and hard-copy letters. [For the full report, see ED627375.]
- Published
- 2023
39. Diabetes/ Endocrine Surveillance in SDS
- Author
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Shwachman Diamond Syndrome Foundation and Barnes-Jewish Hospital
- Published
- 2024
40. AI Does Not Alter Perceptions of Text Messages
- Author
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Diamond, N'yoma
- Subjects
Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Human-Computer Interaction - Abstract
For many people, anxiety, depression, and other social and mental factors can make composing text messages an active challenge. To remedy this problem, large language models (LLMs) may yet prove to be the perfect tool to assist users that would otherwise find texting difficult or stressful. However, despite rapid uptake in LLM usage, considerations for their assistive usage in text message composition have not been explored. A primary concern regarding LLM usage is that poor public sentiment regarding AI introduces the possibility that its usage may harm perceptions of AI-assisted text messages, making usage counter-productive. To (in)validate this possibility, we explore how the belief that a text message did or did not receive AI assistance in composition alters its perceived tone, clarity, and ability to convey intent. In this study, we survey the perceptions of 26 participants on 18 randomly labeled pre-composed text messages. In analyzing the participants' ratings of message tone, clarity, and ability to convey intent, we find that there is no statistically significant evidence that the belief that AI is utilized alters recipient perceptions. This provides hopeful evidence that LLM-based text message composition assistance can be implemented without the risk of counter-productive outcomes.
- Published
- 2024
41. Exploratory Study of Low Dose Psilocybin
- Author
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Diamond Therapeutics Inc. and Peter Hendricks, Professor
- Published
- 2024
42. General Performance Evaluation for Competitive Resource Allocation Games via Unseen Payoff Estimation
- Author
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Diamond, N'yoma and Murai, Fabricio
- Subjects
Computer Science - Computer Science and Game Theory ,Computer Science - Multiagent Systems ,Mathematics - Combinatorics ,Mathematics - Optimization and Control - Abstract
Many high-stakes decision-making problems, such as those found within cybersecurity and economics, can be modeled as competitive resource allocation games. In these games, multiple players must allocate limited resources to overcome their opponent(s), while minimizing any induced individual losses. However, existing means of assessing the performance of resource allocation algorithms are highly disparate and problem-dependent. As a result, evaluating such algorithms is unreliable or impossible in many contexts and applications, especially when considering differing levels of feedback. To resolve this problem, we propose a generalized definition of payoff which uses an arbitrary user-provided function. This unifies performance evaluation under all contexts and levels of feedback. Using this definition, we develop metrics for evaluating player performance, and estimators to approximate them under uncertainty (i.e., bandit or semi-bandit feedback). These metrics and their respective estimators provide a problem-agnostic means to contextualize and evaluate algorithm performance. To validate the accuracy of our estimator, we explore the Colonel Blotto ($\mathcal{CB}$) game as an example. To this end, we propose a graph-pruning approach to efficiently identify feasible opponent decisions, which are used in computing our estimation metrics. Using various resource allocation algorithms and game parameters, a suite of $\mathcal{CB}$ games are simulated and used to compute and evaluate the quality of our estimates. These simulations empirically show our approach to be highly accurate at estimating the metrics associated with the unseen outcomes of an opponent's latent behavior.
- Published
- 2024
43. Asymptotics of the Minimal Feedback Arc Set in Erd\H{o}s-R\'{e}nyi Graphs
- Author
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Diamond, Harvey, Kon, Mark, and Raphael, Louise
- Subjects
Mathematics - Combinatorics ,05C80 (Primary) 05C85, 68W40 (Secondary) - Abstract
Given a directed graph, the Minimal Feedback Arc Set (FAS) problem asks for a minimal set of arcs which, when removed, results in an acyclic graph. Equivalently, the FAS problem asks to find an ordering of the vertices that minimizes the number of feedback arcs. The FAS problem is considered an algorithmic problem of central importance in discrete mathematics. Our purpose in this paper is to consider the problem in the context of Erd\H{o}s-R\'{e}nyi random directed graphs, denoted $D(n,p)$, in which each possible directed arc is included with a fixed probability $p>0$. Our interest is the typical ratio of the number of feedforward arcs to the number of feedback arcs that are removed in the FAS problem. We show that as the number $n$ of vertices goes to infinity the probability that this ratio is greater than $1+\epsilon$ for any fixed $\epsilon > 0$ approaches zero. Similarly, letting $p$ go to zero as $n\rightarrow \infty$ this result remains true if $p>C\log{n}/n$ where $C$ depends on $\epsilon$.
- Published
- 2024
44. Plexus 2024: Navigate
- Author
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Sahagian, Christopher, Gee, Caroline, Nguyen, Huan, Parker, Nicole, Shah, Sana, Weng, Britney, Robinson-Phelps, Avery, Mendoza, Joanne, Koch, Allegra P., O'Dell, Sarah, Sing, Caitlyn, Cho, Kellie, Shah, Saloni, James, A. Ja'Nea, Lawrence, Alison, Cuyegkeng, Andreew, Wang, Annabel, Shaikh, Areej, Hope, Ashley, Goodman, Audrey, Vo, Baotran, Given, Caroline, Diamond, Catherine, Yang, Celina, Rajaram, Chalat, Pascal, Chloe Katherine, Andrade Herrera, Christian J., Makar, Christian, Flores, Cindy, Godenzi, Claire Marie, Danza, Clifford, Haq, C, Segoviano, Danely, Statum, Dee, Fowler, Edward, Span, Eileen Thereasa, Noori, Elaha, Chiao, Elaine, Boyles, Emma, Adesina, Fola, Meyskens, Freank L., Miotto, Gabriella, Choi, Hannah, Gopez Tan, Isabela Carmela, Heilman, Jaclyn G., Mai, Jeannie, Wang, Jenny N., Ventura, Jenny, Martin, Jessica, Shapiro, Johanna, Fong, Kristen, Naser-Saravia, Leonora, Gonzales, Luigi, Magpantay, Maria Angela D., Sanford, Matthew John, Crisostomo Villora, Michael Gabriel, Dang, Nancy, Sonuga, Olamide, McShea, Patrick, Rao, Pranathi, Bolotsky, Samantha, Luna, Sania, Hoenicke Flores, Sarah, Atilano, Shari, Salehi, Shirin, Baveja, Shivali, Green, Stuart Alan, Khan, Sunia, Khurana, Surina, Tran, Thuy-Linh, Nguyen, Tori, Nguyen, Trina, Adams, Zoe, and Noori, Zohal
- Subjects
Plexus ,medical humanities ,creative works ,poetry ,photography ,short essay ,magazine - Abstract
Welcome to the 25th anniversary edition of PLEXUS, UC Irvine School of Medicine’s annual student-organized Journal of Medical Humanities & Arts. To mark this celebratory milestone, it is with great pleasure that I present to you NAVIGATE. In the ever-evolving landscape of medicine, the ability to navigate through challenges and unforeseen obstacles is paramount. NAVIGATE serves as a timely invitation for our colleagues to reflect on the distances traversed and to envision the new horizons that lie ahead. We sought to highlight the constellation of tools utilized when we feel lost and to acknowledge the beacons that steer our actions. The subsequent pages offer its readers profoundinsights into the extraordinary journeys undertaken by the greater UCI Health community. We hope it delivers a sense of direction, solace, and clarity to all readers.As we celebrate our 25th anniversary, wehonor the visionaries, contributors, and readers that have propelled us forward on this remarkable voyage. Their collective support fuels our efforts to serve as a creative outlet for the community, catalyze meaningful discussions, and apply the tenets of medical humanities to foster a cohort of compassionate healers.We extend our deepest gratitude to our faculty advisors Dr. Juliet McMullin and Dr. TanNguyen for their invaluable guidance and for sharing their expertise within the field. We thank the UCISOM Medical Humanities & Arts Program and the UCI Department of Family Medicine for their unwavering support. I invite you to embark on this exploration with us, and witness the intricate tapestry of our contributors’ lived experiences that defines our shared journey in healthcare.Bon voyage,Christopher SahagianEditor-in-ChiefCreative Review — Caroline GeeCreative Review — Huan NguyenCreative Review — Sana ShahDesign — Nicole ParkerDesign — Britney WengFaculty Advisor — Dr. Juliet McMullinFaculty Advisor — Dr. Tan NguyenStaff Advisor — Leonora Naser-Saravia{Front Cover): NEW HEIGHTS Britney Weng, MS1San Pedro de Atacama, Chile(Inner Cover): TRAVERSING Britney Weng, MS1Chile Route 23
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- 2024
45. Computationally restoring the potency of a clinical antibody against Omicron.
- Author
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Desautels, Thomas, Arrildt, Kathryn, Zemla, Adam, Lau, Edmond, Zhu, Fangqiang, Ricci, Dante, Cronin, Stephanie, Zost, Seth, Binshtein, Elad, Scheaffer, Suzanne, Dadonaite, Bernadeta, Petersen, Brenden, Engdahl, Taylor, Chen, Elaine, Handal, Laura, Hall, Lynn, Goforth, John, Vashchenko, Denis, Nguyen, Sam, Weilhammer, Dina, Lo, Jacky, Rubinfeld, Bonnee, Saada, Edwin, Weisenberger, Tracy, Lee, Tek-Hyung, Whitener, Bradley, Case, James, Ladd, Alexander, Silva, Mary, Haluska, Rebecca, Grzesiak, Emilia, Earnhart, Christopher, Hopkins, Svetlana, Bates, Thomas, Thackray, Larissa, Segelke, Brent, Lillo, Antonietta, Sundaram, Shivshankar, Bloom, Jesse, Diamond, Michael, Crowe, James, Carnahan, Robert, and Faissol, Daniel
- Subjects
Animals ,Female ,Humans ,Mice ,Antibodies ,Monoclonal ,Antibodies ,Neutralizing ,Antibodies ,Viral ,COVID-19 ,Mutation ,Neutralization Tests ,SARS-CoV-2 ,Spike Glycoprotein ,Coronavirus ,DNA Mutational Analysis ,Antigenic Drift and Shift ,Drug Design ,Computer Simulation - Abstract
The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs1-3 and revealed how quickly viral escape can curtail effective options4,5. When the SARS-CoV-2 Omicron variant emerged in 2021, many antibody drug products lost potency, including Evusheld and its constituent, cilgavimab4-6. Cilgavimab, like its progenitor COV2-2130, is a class 3 antibody that is compatible with other antibodies in combination4 and is challenging to replace with existing approaches. Rapidly modifying such high-value antibodies to restore efficacy against emerging variants is a compelling mitigation strategy. We sought to redesign and renew the efficacy of COV2-2130 against Omicron BA.1 and BA.1.1 strains while maintaining efficacy against the dominant Delta variant. Here we show that our computationally redesigned antibody, 2130-1-0114-112, achieves this objective, simultaneously increases neutralization potency against Delta and subsequent variants of concern, and provides protection in vivo against the strains tested: WA1/2020, BA.1.1 and BA.5. Deep mutational scanning of tens of thousands of pseudovirus variants reveals that 2130-1-0114-112 improves broad potency without increasing escape liabilities. Our results suggest that computational approaches can optimize an antibody to target multiple escape variants, while simultaneously enriching potency. Our computational approach does not require experimental iterations or pre-existing binding data, thus enabling rapid response strategies to address escape variants or lessen escape vulnerabilities.
- Published
- 2024
46. Mechanisms, detection and impacts of species redistributions under climate change
- Author
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Lawlor, Jake A, Comte, Lise, Grenouillet, Gaël, Lenoir, Jonathan, Baecher, J Alex, Bandara, RMWJ, Bertrand, Romain, Chen, I-Ching, Diamond, Sarah E, Lancaster, Lesley T, Moore, Nikki, Murienne, Jerome, Oliveira, Brunno F, Pecl, Gretta T, Pinsky, Malin L, Rolland, Jonathan, Rubenstein, Madeleine, Scheffers, Brett R, Thompson, Laura M, van Amerom, Brit, Villalobos, Fabricio, Weiskopf, Sarah R, and Sunday, Jennifer
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Climate Change Impacts and Adaptation ,Biological Sciences ,Environmental Sciences ,Climate Action - Published
- 2024
47. Mesoscopic transport in KSTAR plasmas: avalanches and the E × B staircase
- Author
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Choi, Minjun J, Kwon, Jaemin, Qi, Lei, Diamond, Patrick H, Hahm, Taik-Soo, Jhang, Hogun, Kim, Juhyung, Leconte, Michael, Kim, Hyun-Seok, Kang, Jisung, Park, Byoung-Ho, Chung, Jinil, Lee, Jaehyun, Kim, Minho, Yun, Gunsu S, Nam, YU, Kim, Jaewook, Ko, Won-Ha, Lee, Kyu-Dong, and Juhn, June-Woo
- Subjects
Nuclear and Plasma Physics ,Physical Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Other Physical Sciences ,Fluids & Plasmas ,Nuclear and plasma physics - Abstract
Abstract: The self-organization is one of the most interesting phenomena in the non-equilibrium complex system, generating ordered structures of different sizes and durations. In tokamak plasmas, various self-organized phenomena have been reported, and two of them, coexisting in the near-marginal (interaction dominant) regime, are avalanches and the E × B staircase. Avalanches mean the ballistic flux propagation event through successive interactions as it propagates, and the E × B staircase means a globally ordered pattern of self-organized zonal flow layers. Various models have been suggested to understand their characteristics and relation, but experimental researches have been mostly limited to the demonstration of their existence. Here we report detailed analyses of their dynamics and statistics and explain their relation. Avalanches influence the formation and the width distribution of the E × B staircase, while the E × B staircase confines avalanches within its mesoscopic width until dissipated or penetrated. Our perspective to consider them the self-organization phenomena enhances our fundamental understanding of them as well as links our findings with the self-organization of mesoscopic structures in various complex systems.
- Published
- 2024
48. On how structures convey non-diffusive turbulence spreading
- Author
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Long, Ting, Diamond, Patrick H, Ke, Rui, Chen, Zhipeng, Cao, Mingyun, Xu, Xin, Xu, Min, Hong, Rongjie, Tian, Wenjing, Yuan, Jinbang, Liu, Yanmin, Yan, Qinghao, Yang, Qinghu, Shen, Chengshuo, Guo, Weixin, Wang, Lu, Nie, Lin, Wang, Zhanhui, Hao, Guangzhou, Wang, Nengchao, Chen, Zhongyong, Pan, Yuan, Li, Jiquan, Chen, Wei, and Zhong, Wulyu
- Subjects
Nuclear and Plasma Physics ,Physical Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Fluids & Plasmas ,Nuclear and plasma physics - Abstract
Abstract: We report on comprehensive experimental studies of turbulence spreading in edge plasmas. These studies demonstrate the relation of turbulence spreading and entrainment to intermittent convective density fluctuation events or bursts (i.e. blobs and holes). The non-diffusive character of turbulence spreading is thus elucidated. The turbulence spreading velocity (or mean jet velocity) manifests a linear correlation with the skewness of density fluctuations, and increases with the auto-correlation time of density fluctuations. Turbulence spreading by positive density fluctuations is outward, while spreading by negative density fluctuations is inward. The degree of symmetry breaking between outward propagating blobs and inward propagating holes increases with the amplitude of density fluctuations. Thus, blob-hole asymmetry emerges as crucial to turbulence spreading. These results highlight the important role of intermittent convective events in conveying the spreading of turbulence, and constitute a fundamental challenge to existing diffusive models of spreading.
- Published
- 2024
49. Early adversity and sexual diversity: the importance of self-reported and neurobiological sexual reward sensitivity.
- Author
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Alley, Jenna, McDonnell, Amy, and Diamond, Lisa
- Subjects
EEG reward sensitivity ,Early adversity ,Life History Theory ,Sexual diversity ,Sexual risk taking ,Humans ,Male ,Female ,Child ,Self Report ,Sexual Behavior ,Sexual Partners ,Gender Identity ,Reward - Abstract
Work shows that sexually-diverse individuals face high rates of early life adversity and in turn increased engagement in behavioral outcomes traditionally associated with adversity, such as sexual risk taking. Recent theoretical work suggests that these associations may be attributable to heightened sexual reward sensitivity among adversity-exposed women. We aimed to test these claims using a combination of self-report and EEG measures to test the relationship between early adversity, sexual reward sensitivity (both self-reported and EEG measured) and sexual risk taking in a sexually diverse sample of cis-gender women (N = 208) (Mage = 27.17, SD = 6.36). Results showed that childhood SES predicted self-reported sexual reward sensitivity which in turn predicted numbers of male and female sexual partners. In contrast we found that perceived childhood unpredictability predicted neurobiological sexual reward sensitivity as measured by EEG which in turn predicted male sexual partner number. The results presented here provide support for the notion that heightened sexual reward sensitivity may be a pathway through which early life adversity augments future sexual behavior, and underscores the importance of including greater attention to the dynamics of pleasure and reward in sexual health promotion.
- Published
- 2024
50. Bringing traits back into the equation: A roadmap to understand species redistribution
- Author
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Comte, Lise, Bertrand, Romain, Diamond, Sarah, Lancaster, Lesley T, Pinsky, Malin L, Scheffers, Brett R, Baecher, J Alex, Bandara, RMWJ, Chen, I‐Ching, Lawlor, Jake A, Moore, Nikki A, Oliveira, Brunno F, Murienne, Jerome, Rolland, Jonathan, Rubenstein, Madeleine A, Sunday, Jennifer, Thompson, Laura M, Villalobos, Fabricio, Weiskopf, Sarah R, and Lenoir, Jonathan
- Subjects
Climate Change Impacts and Adaptation ,Biological Sciences ,Environmental Sciences ,Climate Action ,Phylogeny ,Biodiversity ,Climate Change ,Geography ,Phenotype ,climate change ,leading edge ,mechanism ,population dynamics ,research bias ,species range shift ,trailing edge ,trait-based approach ,trait‐based approach ,Ecology ,Biological sciences ,Earth sciences ,Environmental sciences - Abstract
Ecological and evolutionary theories have proposed that species traits should be important in mediating species responses to contemporary climate change; yet, empirical evidence has so far provided mixed evidence for the role of behavioral, life history, or ecological characteristics in facilitating or hindering species range shifts. As such, the utility of trait-based approaches to predict species redistribution under climate change has been called into question. We develop the perspective, supported by evidence, that trait variation, if used carefully can have high potential utility, but that past analyses have in many cases failed to identify an explanatory value for traits by not fully embracing the complexity of species range shifts. First, we discuss the relevant theory linking species traits to range shift processes at the leading (expansion) and trailing (contraction) edges of species distributions and highlight the need to clarify the mechanistic basis of trait-based approaches. Second, we provide a brief overview of range shift-trait studies and identify new opportunities for trait integration that consider range-specific processes and intraspecific variability. Third, we explore the circumstances under which environmental and biotic context dependencies are likely to affect our ability to identify the contribution of species traits to range shift processes. Finally, we propose that revealing the role of traits in shaping species redistribution may likely require accounting for methodological variation arising from the range shift estimation process as well as addressing existing functional, geographical, and phylogenetic biases. We provide a series of considerations for more effectively integrating traits as well as extrinsic and methodological factors into species redistribution research. Together, these analytical approaches promise stronger mechanistic and predictive understanding that can help society mitigate and adapt to the effects of climate change on biodiversity.
- Published
- 2024
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