Search

The fifth addition of this classic text that focuses on the diabetic foot continues the tradition of the previous four editions. More specifically, it includes contributions from a distinguished panel of clinicians and researchers, who have either participated in previous editions or are new, who provide up-to-date information on the pathophysiology and management of diabetic foot ulceration. As with the previous editions, it is divided into three sections: the first part focuses on clinical features and diagnosis; the second on pathophysiology; and the third on the management of diabetic foot problems. The main emphasis of the clinical part is on the multidisciplinary approach that has been mainly developed by the world-renowned Joslin-Beth Israel Deaconess Foot Center, which pioneered the management of diabetic lower extremity problems. Also like previous editions, the author panel includes diabetologists, podiatrists, vascular surgeons, infectious disease specialists,orthotists, plastic and orthopedic surgeons, the majority of whom work at the Joslin-Beth Israel Deaconess Foot Center. In addition, the fifth edition not only describes the state-of-the-art current methods in clinical practice but also includes a thorough update of all research progress during the last five years. This updated edition of this timely text will be of significant value to all physicians and researchers with interest in a comprehensive understanding of the diabetic foot.

Myopathies and Tendinopathies of the Diabetic Foot: Anatomy, Pathomechanics, and Imaging is a unique reference of valuable instructive data that reinforces the understanding of myopathies and tendinopathies related to diabetes-induced Charcot foot. Diabetic myopathies usually precede other complications (i.e., deformity, ulceration, infection) seen in the diabetic foot. Oftentimes, these myopathies may be isolated especially during their initial stage. In the absence of clinical information relevant to diabetes, the solitaire occurrence of myopathies may lead to confusion, misinterpretation, and misdiagnosis. The misdiagnosis can cause delay of management and consequent high morbidity. This book emphasizes the complications of diabetic myopathies and tendinopathies and all their aspects, including pathophysiology, pathomechanics, imaging protocols, radiological manifestations, histological characteristics, and surgical management.Diabetes type II and its complications (diabetic myopathies and tendinopathies) have reached a dreadful high incidence worldwide. Likewise, the need for better understanding of these complications becomes indispensable. In this book, the readers of all genres will find all they need to know about these conditions. This book serves as a classic academic reference for educators, healthcare specialists, healthcare givers, and healthcare students. - Presents dedicated chapters on tendons and myotendinous junction which are anatomical components frequently ignored in the study of muscles - Includes descriptions of diabetic foot myopathies featured by magnetic resonance imaging (MRI) - Provides illustrations of myopathies and tendinopathies with state-of-the-art MRI images and MR imaging protocols for myopathies - Covers anatomical and biomechanic descriptions of all intrinsic and extrinsic muscles

This heavily revised second edition of this essential text address the challenges of treating foot complications associated with diabetes, which is presently a major challenge for societies the world over with many patients not receiving adequate care. The work is divided into prevention and early management, management of major complications, prevention of recurrence and how to structure a team. Authors include experienced podiatrists, nurses and doctors, all of whom currently work in the field of diabetes foot care. Emphasis is placed in each area on how to practically apply the content covered to solve clinical problems that can be encountered on a day-to-day basis. New topics covered in this edition include how to avoid litigation, metrics for defining success along with the role of regional networks and how data should be collectedManagement of Diabetic Foot Complications, Second Edition comprehensively covers how to treat these complications in diabetic patients. Therefore, it is a valuable resources for anyone responsible for the care of people with diabetes who may be at risk of developing foot complications.

This book discusses optical technologies for Diabetic Foot management. It combines the current medical literature review with an overview of the technology and physics behind it. Thus, it is a single-source introduction to the topic. It can also be used as a reference source and practical guide for the use of technology. The particular focus is on low-cost technologies, including hyperspectral imaging, thermography, and endogenous bacterial fluorescence. Moving diagnostic modalities closer to the patient (e.g., primary care) allows the disease to be detected at an earlier stage, thus improving outcomes. However, while some optical technologies are available commercially, they have not received wide clinical adoption due to gaps in knowledge translation to mainstream medicine. This book aims to narrow this gap with practical illustrations. The book will be of interest to a broad range of healthcare professionals, clinical researchers, engineers, and decision-makers, who are dealing with complications of diabetes.Key Features: Reviews the current state of technologies Provides a practical guide with practical considerations and illustrations Supplies a 360-degree view of the combination of clinical information with a technology background and primers on physics and engineering

This book contains 13 chapters. It deals with diabetic foot syndrome from the multidisciplinary point of view of several experts: a vascular surgeon, diabetologist, surgeon, podiatrist, radiologist, neurologist, and anesthesiologist. The introductory chapters have the character of propaedeutics, which is also important for pre-graduate education. The following chapters deal with the origin of the syndrome, its occurrence, its diagnosis, therapeutic procedures, associated neurological disorders, and the care of a podiatrist and an anesthesiologist when pain persists. Other parts are reserved for surgical and endovascular arterial treatment by vascular surgeons and interventional angiologists, not forgetting the issue of amputations and proper rehabilitation of patients with diabetes. Vascular surgeons, angiologists, general surgeons, diabetologists, neurologists, radiologists, podiatrists, and general practitioners will find instructions in the book. The book is a source of the latest theoretical and practical information for postgraduate education of the above-mentioned experts.

This book aims to provide a comprehensive overview of the foot in diabetes and its management from a team of experts. It is recommended to anybody with an interest in the diagnosis, management, surgical treatment, and indeed prevention of diabetic foot ulcers. It is presented in logical order from anatomy and biomechanics of the foot followed by chapters on causal pathways, neuropathy, peripheral arterial disease, and then infections of the diabetic foot. Finally, there are chapters on routine podiatric care and other therapies including surgery. The book ends with a chapter on ‘Recent Advances in Diabetic Foot Management'.

Obesity is a worldwide epidemic that affects half a billion people. It has been estimated that, if current trends continue, by 2050, 60% of men and 50% of women worldwide will be obese. Hypertrophy and hyperplasia of white adipose tissue caused by overweight and obesity lead to a chronic inflammatory state, which results in impaired insulin sensitivity and the development of diabetes. Currently, the number of people affected by diabetes globally exceeds 400 million (rising more rapidly in low- and middle-income countries). In 2019, diabetes was the ninth leading cause of mortality, with an estimated 1.5 million direct deaths. This book provides a comprehensive overview of the relationship between inflammation, obesity, and diabetes. It focuses on the pathogenesis and biological mechanisms of obesity, the interaction between adipose tissue and the immune system, the role of genetic and environmental factors, the progression of cardiovascular complications, and the associationof obesity and inflammation with type 1 and type 2 diabetes, as well as gestational diabetes. This volume also includes practical recommendations for preventing and managing these conditions using both lifestyle modifications and pharmacological interventions. Written by experts in the field, Obesity, Diabetes and Inflammation: Molecular Mechanisms and Clinical Management addresses the role of inflammation in both obesity and diabetes, its effect on vascular and non-vascular pathologies, oxidative stress, genetics, and epigenetics. This text aims to be a valuable resource for researchers, clinicians, and students of medicine at all levels.

Diabetes mellitus is a global epidemic with severe complications that can be of great cost. This book focuses on the complications of hypertension, heart attack or heart failure, stroke, blindness, nephropathy, neuropathy, amputations, and death, along with the prevalence and prevention of disease development. It explains distribution of the disease by age and gender, such as the development of type II diabetes in relation to obesity, which is more prevalent in younger age groups. Global mortality and costs of complications are significant, as the disease affects all ages, races, and ethnicities, making this book an invaluable resource for healthcare professionals and students everywhere. Key Features A useful ready reference for students, physicians, and healthcare professionals detailing the latest diagnostic tests and treatments of diabetes and its complications Explains how heart failure and stroke are deadly complications of diabetes along with kidney failure and life-threatening infections Establishes how cancer is linked to diabetes – a fact many people are not aware of – this book details the six types of cancer that may result from the disease, along with an individualized focus on the different'areas'of issues that occur from diabetes Discusses the effect of diabetes on the minds of patients, in relation to depression, anxiety, panic, PTSD, eating disorders, delirium, and dementia

Die Herausgeber haben die Oberfläche des Fußes in Bereiche aufgeteilt, in denen Ulzera auf ähnliche Weise auftreten. Aus den so gefundenen „Entitäten“ leiten sie übersichtlich auch komplexe Therapiemöglichkeiten ab. Dieses Prinzip „Von der Entität zur Therapie“ hat die 1. Auflage innerhalb kurzer Zeit zu einem Standardwerk werden lassen, das ins Englische und Chinesische übersetzt wurde. 2019 wurde das Werk in englischer Sprache mit der Stromeyer-Probst-Medaille der Deutschen Gesellschaft für Unfallchirurgie ausgezeichnet. Die 2. Auflage wurde komplett überarbeitet und erweitert. Das Diabetische Fußsyndrom wird nun in allen wichtigen Aspekten abgebildet.

The Essential Charcot Neuroarthropathy: Biomechanics, Pathophysiology, and MRI Findings provides a comprehensive analysis of Charcot neuroarthropathy (or Charcot Foot) in diabetic patients. All aspects are covered, including epidemiology, biomechanics, pathophysiology, socioeconomic impacts, radiological findings, and differential diagnosis, with an emphasis on MRI. Chapters address the challenges of pre-and-post surgical management of Charcot neuroarthropathy and the role of unconventional imaging modalities in diagnosis. The book presents an analysis of the normal biomechanics of the ankle and foot, the biomechanical derangements of the ankle-foot unit (including abnormal gait) caused by diabetes Type II, and more. Finally, there is also a reference of the pathophysiology of diabetes-induced peripheral neuropathy and its direct link with the development of Charcot neuroarthropathy foot. Diabetes-induced Charcot foot is frequently misunderstood, misinterpreted and misdiagnosed which can lead to confusion and detrimental management with reported high morbidity. - Presents a clear differentiation of Charcot neuroarthropathy with other conditions such as osteoarthritis, gout, psoriasis, rheumatoid arthritis, the Madura foot, and others - Provides a state-of-art catalogue of all radiological features of Charcot neuroarthropathy with MRI - Describes the pre-and post-surgical procedures used for the management of Charcot neuroarthropathy and their socioeconomic impacts - Includes MRI color images of soft tissue damages for ease of understanding

The book focuses on diabetic macular edema and provides comprehensive practical knowledge on the subject. This timely book summarizes all the aspects of diabetic macular edema. The book is edited by leading authorities of vitreoretinal diseases having expertise in diabetic macular edema. It comprises over dozen chapters, authored by a subject authority in the world. Chapters provide diagnostic, medical and surgical approach. The book is clinically relevant, covers application of the latest clinical trials as well as application of novel imaging technologies. It includes uniquely structured chapters for easy learning.The book is beneficial to ophthalmic resident doctors, retina fellows and practicing retina specialists throughout the world.

•Basic and clinical science with focus on epidemiology, barriers and challenges in diabetes management, and diagnosis. •Brief overview with clinical perspective on managing diabetes with cardiovascular complications such as hypertension, stroke, and cardiomyopathy. •Pragmatic recommendations on managing patients with diabetes and cardiovascular disease.

Welches Wissen ist nötig, um Begleit- und Folgeerkrankungen von Diabetes Mellitus möglichst zu vermeiden, bei Bedarf zu erkennen und gezielt zu behandeln? Diabetes ist eine der großen Herausforderungen für das Gesundheitswesen im 21. Jahrhundert. Dies ist alleine schon demographisch begründet und bei einer Prävalenz von >8% in Deutschland (derzeit ca. 10 Mio. Betroffene) wird eine weitere Steigerung um 22% bis 2030 erwartet. Neben der guten Einstellung der Stoffwechselstörung spielen die Komplikationen des Diabetes eine eminent wichtige Rolle. Denn die Morbidität und Mortalität des Diabetes wird primär durch die ihn begleitenden Komplikationen determiniert. Die Komplikationsrate für kardiovaskuläre Ereignisse und Schlaganfall ist bei Diabetes ca. 2- bis 4-fach erhöht. Jeder 3. Patient ab 40. Jahren erkrankt an einer diabetischen Retinopathie, jeder 4. Diabetiker erleidet ein diabetisches Fußsyndrom; bis zu 40% aller Menschen mit Diabetes entwickeln Nierenerkrankungen. Dieses Buch beschreibt praxisnah die Komplikationen und spezifischen Besonderheiten bei Diabetes. Neben einer kurzen Einführung zur Epidemiologie und Ätiopathogenese der jeweiligen Komplikation liegt der Fokus auf der Darstellung der Leitlinien gerechten Diagnostik und Therapie - graphisch anschaulich dargestellt, gezielt auffindbar und unmittelbar praktisch mit Hilfe von Checklisten anwendbar.

Diabetes and the Eye familiarizes the reader with the relationship between diabetes mellitus and the visual system. It presents a discussion about the diabetes epidemic and the many ways the disease can cause vision loss, with several types of vision disorders covered in separate chapters. Information about new frontiers in the treatment of ophthalmic disorders is also presented to reflect the advances being made in the clinic.Key features:- presents detailed coverage of vision loss in diabetes in 12 organized and easy to read chapters- includes a discussion on the diabetes epidemic- covers a wide range of vision disorders, of different parts of the eye- includes information on current practices in eye care and management for diabetic patients- includes information about relevant diagnostic toolsThis book serves as a useful handbook for medical students, residents in ophthalmology, community and academic ophthalmologists, as well as members of the internal medicine and family practice communities.

This book discusses essential aspects of diabetic foot ulcers, including evidence-based information on its pathogenesis and pathophysiology, as well as the molecular mechanisms and biomechanics of the diabetic foot. It also highlights the need for a multidisciplinary team to be involved in the management of diabetic patients with foot ulcers, and describes available and future tools for evaluating patients who are at risk. Exploring the main current therapies as well as the latest developments, future directions and potential new treatments, such as growth factors, stem cell therapy, alternative medicine and nanotechnology, the book is a valuable resource for clinicians and medical graduates but will also appeal to researchers working in the field.

The Science, Etiology and Mechanobiology of Diabetes and Its Complications presents the most comprehensive synthesis of contemporary global research on diabetes, covering a novel and unique mechanobiological perspective – addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. The book provides a unique approach to communicating diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycemia. Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here. - Covers the state-of-knowledge in diabetes research from a mechanobiological perspective, including cell death and (neural, connective, adipose, vascular, renal etc.) tissue damage cascades and healing processes - Describes state-of-the-art technology in prevention, diagnosis, prognosis and treatment of tissue, organ and body system damage caused by chronic hyperglycemia and diabetes - Explores emerging research directions and future technology trends in the field of diabetes prevention and care, including common complications of diabetes (foot ulcers and amputation, peripheral neuropathy, retinal damage, renal damage, vascular and cardiac damage, connective tissue damage etc.) at the early stage of research and development in academia and industry

Diabetes mellitus is one of the major causes of morbidity and mortality in the modern world. Persistent hyperglycaemia is responsible for several complications of diabetes, such as diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, diabetic cardiomyopathy, diabetic autonomic neuropathy, diabetic ketoacidosis, diabetic foot ulcer, gestational diabetes, and diabetic mastopathy. With the advancement of technology, several new drugs have been developed for treatment of diabetes and diabetic complications. Moreover, alternative and complementary medicines have also been employed to manage diabetes and its associated complications. Despite the availability of a plethora of therapeutic agents, the management of diabetes and diabetic complications is an uphill battle associated with several limitations. Various leading research groups across the world are investing billions of dollars to develop impeccable solutions for the treatment of diabetes and diabetic complications. This book focuses on the understanding of recent advancements in the pathogenesis of diabetes and diabetic complications, the molecular basis of the disease and recent advancements in diabetic treatment. The chapters are specifically dedicated to different complications associated with diabetes. Moreover, recent advances in treatments and medications in clinical trials for these complications are explained. Some chapters are dedicated to the use of herbal medicines, alternative and complementary therapy and personalized medicines. Furthermore, the role of epigenetics in diabetic complications is described, as well as the role of antidiabetic drugs and their interactions. Due to its widespread prevalence, diabetes is presently considered a pandemic. This book provides contemporary information to researchers and health care practitioners about diabetes and diabetic complications, which may pave the way for designing new strategies to manage diabetes and diabetic complications. Moreover, the insights on alternative and complementary medicines will help in providing a background for inclusion of these medicines as an important therapeutic option for treatment of diabetes.

This book presents essential information on biomechanical features of the diabetic foot, which could help to minimize the risk of future diabetic foot problems. India has recently been classified as the ‘diabetic capital'of the world. Type 2 diabetes mellitus has become a serious concern for Indian society, where the prevalence rate is increasing exponentially. Similarly, the comorbidities and foot complications of type 2 diabetes mellitus are worsening day by day. Of all complications, diabetes peripheral neuropathy is the most common, and leads to foot deformities, pain, altered sensation, loss of foot arch, etc. The ultimate fate can even be gangrene and amputation. Accordingly, foot complications of diabetes represent a pressing medical issue. Sharing insights into diabetic foot syndrome, its causative factors, prevention and management, this book offers a valuable resource for medical and paramedical students, researchers, podiatrists, surgeons, and physicians alike.

Diabetes and Retinopathy brings together the multifaceted information about the research and clinical application from academic, clinical, bioengineering and bioinformatics perspectives. The editors bring together a stellar cast of authors to pull together this diverse and interesting field. Academic researchers, bioengineers, new investigators and students interested in diabetes and retinopathy need an authoritative reference to bring this multidisciplinary field together to reduce the amount of time spent on source-searching and more time on actual research and the clinical application. This reference depicts the current clinical understanding of DR as well as the many scientific advances in understanding this condition. - Provides valuable information for academic clinicians, researchers, bioengineers and industry on diabetes and retinopathy - Discusses the impact of diabetic retinopathy, a major cause of new-onset visual loss in all the industrialized nations - Covers statistical classification techniques and risk stratification

Diabetic foot complications are serious, common and often difficult to manage adequately. This book provides a concise, clinically focused approach to the diagnosis and management of the diabetic foot at the primary care level. It is specifically designed to highlight prevention, diagnosis, managing at-risk feet, controlling risk factors, and the latest international guidelines. The book takes a logical and practical primary care-based approach in managing various conditions, including hard calluses, fungal infections, bacterial infections, neuropathy, ulceration, and life-threatening limb conditions.

Now in its second edition, this comprehensive handbook provides a state-of-the-art overview of recent advances in drug and non-drug therapies for obesity and diabetes. It also addresses major comorbidities, covering topics such as, cardiovascular diseases, renal and neuropsychiatric disorders, appetite control and micro RNAs. Special attention is also devoted to pediatric care, including the latest recommendations for therapy and prevention. Obesity and type 2 diabetes are among the top global health-care budget concerns worldwide and impact professional practice at all levels: in hospitals, clinics and physicians'offices alike. They prominently feature in headlines, and virtually no family, community or country is exempt from their protean, deleterious consequences. Furthermore, given the multiple intersections in their pathways, they often go hand in hand.The good news is that scientific advances in all fields, including genomics, metabolomics, lipidomics and microbiomics, are increasing our understanding of these two disease areas. At the same time, artificial intelligence, machine learning, mobile health and advanced implantable and external devices are rendering prevention and management more available, safe and cost-effective. In addition, bariatric and metabolic surgery has evolved from a niche specialty to an officially endorsed option for several modalities of obesity and diabetes. This book presents the latest lifestyle, pharmacological, surgical and non-surgical treatment options, including endoscopic intervention and cell therapy. Objectively reviewing natural and artificial sweeteners and critically examining issues such as public health initiatives, government mandated taxes for unhealthy foods and environmental planning, no stone is left unturned in gathering the latest practical information. As such, the book will appeal to seasoned specialists, as well as students and healthcare professionals in training.

'Diabetes mellitus, one of the most important complications of pregnancy, can cause a wide range of problems during pregnancy for women and their developing babies. This book is published with the objective of providing a comprehensive overview of the clinical characteristics/features of types 1 and 2 diabetes in pregnancy as well as gestational diabetes mellitus (GDM). To reach this aim, the focus is on up-to-date information on physiopathology, diagnosis, autoimmunity, genetic, omics, management, and treatment'--

Diabetes Mellitus: Impact on Bone, Dental and Musculoskeletal Health focuses on the under recognized and managed conditions associated with diabetes, including impacts on bone health, dental health, hand, and foot disorders, wounds, infections, and musculoskeletal disorders. A full understanding of the relationship of diabetes to skeletal disorders remains elusive and many physicians who deal with such issues are unclear about causes and management. While the macro- and microvascular complications associated with diabetes mellitus are well known, complications associated with bone, dental and musculoskeletal health are not. Endocrinologists, primary care physicians, geriatricians, podiatrists, dentists, and researchers interested in diabetes mellitus associated bone, dental and musculoskeletal disorders will find this to be a comprehensive tome on the topic. - Covers clinically important complications of diabetes that are less understood - Presents up-to-date, thoroughly referenced information for both clinicians, researchers and other healthcare providers - Highlights current research and treatment for skeletal deficits and complications due to diabetes types 1 and 2 - Serves as a one-stop resource for the bone, dental and muscular disorders associated with diabetes mellitus

Published in 1988: The enormous literature, scattered through journals devoted to physiology, biochemistry, pharmacology, ultrastructure, and clinical medicine, together with the laboratory observations of the authors, is reviewed and integrated in an effort to portray the origin, evolution, and consequences of heart dysfunction during diabetes.

This book provides a practical guide to the treatment of patients as risk from limb amputation. The most common presentations of the diabetic foot are presented in concise and evidence-based chapters covering the neuropathic foot, the Charcot foot, the ischemic foot, and the infected foot. Each section includes an introduction to the clinical approach as well as an algorithm illustrating the limb salvage pathway and intervention steps. Limb Salvage of the Diabetic Foot: An Interdisciplinary Approach aims to help the reader build an interdisciplinary understanding of the diabetic foot and its treatment and is of interest to all members of the interdisciplinary diabetic foot team including surgeons, podiatrists, radiologists, nurses, orthotists, infectious disease physicians, and endocrinologists.

A critical study of diabetes in the popular imaginationOver twenty-nine million people in the United States, more than nine percent of the population, have some form of diabetes. In Managing Diabetes, Jeffrey A. Bennett focuses on how the disease is imagined in public culture. Bennett argues that popular anecdotes, media representation, and communal myths are as meaningful as medical and scientific understandings of the disease. In focusing on the public character of the disease, Bennett looks at health campaigns and promotions as well as the debate over public figures like Sonia Sotomayor and her management of type 1 diabetes. Bennett examines the confusing and contradictory public depictions of diabetes to demonstrate how management of the disease is not only clinical but also cultural. Bennett also has type 1 diabetes and speaks from personal experience about the many misunderstandings and myths that are alive in the popular imagination. Ultimately, Managing Diabetes offers a fresh take on how disease is understood in contemporary society and the ways that stigma, fatalism, and health can intersect to shape diabetes's public character. This disease has dire health implications, and rates keep rising. Bennett argues that until it is better understood it cannot be better treated.