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106 results on '"DiPietro, R."'

1. Determining Magnetic Nanoparticle Size Distributions from Thermomagnetic Measurements

Author

DiPietro, R. S., Johnson, H. G., Bennett, S. P., Nummy, T. J., Lewis, L. H., and Heiman, D.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Thermomagnetic measurements are used to obtain the size distribution and anisotropy of magnetic nanoparticles. An analytical transformation method is described which utilizes temperature-dependent zero-field cooling (ZFC) magnetization data to provide a quantitative measurement of the average diameter and relative abundance of superparamagnetic nanoparticles. Applying this method to self-assembled MnAs nanoparticles in MnAs-GaAs composite films reveals a log-normal size distribution and reduced anisotropy for nanoparticles compared to bulk materials. This analytical technique holds promise for rapid assessment of the size distribution of an ensemble of superparamagnetic nanoparticles., Comment: Correction Appl. Phys. Lett. 98, 216103 (2011)

Published
2010
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2. Long-term Effects of Octreotide on Liver Volume in Patients With Polycystic Kidney and Liver Disease

Author

Pisani, A., Sabbatini, M., Ruggenenti, P., Remuzzi, G., Visciano, B., Amicone, M., Dipietro, R., Mozzillo, G., Riccio, E., Rossano, R., Spinelli, L., Santangelo, M., Rubis, N., Diadei, O., Calini, W., Villa, A., Sabatella, M., Ene-Iordache, B., Carminati, S., Martinetti, D., Giuliano, G.A., Perna, A., Liuzzi, R., Remuzzi, A., Imbriaco, M., Prinster, A., Altiero, M., Boccardo, P., Peracchi, S., Pisani, Antonio, Sabbatini, Massimo, Imbriaco, Massimo, Riccio, Eleonora, Rubis, Nadia, Prinster, Anna, Perna, Annalisa, Liuzzi, Raffaele, Spinelli, Letizia, Santangelo, Michele, Remuzzi, Giuseppe, and Ruggenenti, Piero

Published
2016
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5. Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Author

Dreyer, SB, Upstill-Goddard, R, Paulus-Hock, V, Paris, C, Lampraki, EM, Dray, E, Serrels, B, Caligiuri, G, Rebus, S, Plenker, D, Galluzzo, Z, Brunton, H, Cunningham, R, Tesson, M, Nourse, C, Bailey, UM, Jones, MD, Moran-Jones, K, Wright, DW, Duthie, F, Oien, K, Evers, L, McKay, CJ, McGregor, GA, Gulati, A, Brough, R, Bajrami, I, Pettitt, S, Dziubinski, ML, Candido, J, Balkwill, F, Barry, ST, Grützmann, R, Rahib, L, Allison, S, Bailey, PJ, Biankin, AV, Beraldi, D, Cameron, E, Chang, DK, Cooke, SL, Grimwood, P, Kelly, S, Marshall, J, Martin, S, McDade, B, McElroy, D, Musgrove, EA, Ramsay, D, Wright, D, Hair, J, Jamieson, NB, Westwood, P, Williams, N, Johns, AL, Mawson, A, Scarlett, CJ, Brancato, MAL, Rowe, SJ, Simpson, SH, Martyn-Smith, M, Thomas, MT, Chantrill, LA, Chin, VT, Chou, A, Cowley, MJ, Humphris, JL, Mead, RS, Nagrial, AM, Pajic, M, Pettit, J, Pinese, M, Rooman, I, Wu, J, Tao, J, DiPietro, R, Watson, C, Steinmann, A, Lee, HC, Wong, R, Pinho, AV, Giry-Laterriere, M, Daly, RJ, Sutherland, RL, Grimmond, SM, Waddell, N, Kassahn, KS, Miller, DK, Wilson, PJ, Patch, AM, Song, S, Harliwong, I, Idrisoglu, S, Nourbakhsh, E, Manning, S, Wani, S, Gongora, M, Anderson, M, Holmes, O, Leonard, C, Dreyer, SB, Upstill-Goddard, R, Paulus-Hock, V, Paris, C, Lampraki, EM, Dray, E, Serrels, B, Caligiuri, G, Rebus, S, Plenker, D, Galluzzo, Z, Brunton, H, Cunningham, R, Tesson, M, Nourse, C, Bailey, UM, Jones, MD, Moran-Jones, K, Wright, DW, Duthie, F, Oien, K, Evers, L, McKay, CJ, McGregor, GA, Gulati, A, Brough, R, Bajrami, I, Pettitt, S, Dziubinski, ML, Candido, J, Balkwill, F, Barry, ST, Grützmann, R, Rahib, L, Allison, S, Bailey, PJ, Biankin, AV, Beraldi, D, Cameron, E, Chang, DK, Cooke, SL, Grimwood, P, Kelly, S, Marshall, J, Martin, S, McDade, B, McElroy, D, Musgrove, EA, Ramsay, D, Wright, D, Hair, J, Jamieson, NB, Westwood, P, Williams, N, Johns, AL, Mawson, A, Scarlett, CJ, Brancato, MAL, Rowe, SJ, Simpson, SH, Martyn-Smith, M, Thomas, MT, Chantrill, LA, Chin, VT, Chou, A, Cowley, MJ, Humphris, JL, Mead, RS, Nagrial, AM, Pajic, M, Pettit, J, Pinese, M, Rooman, I, Wu, J, Tao, J, DiPietro, R, Watson, C, Steinmann, A, Lee, HC, Wong, R, Pinho, AV, Giry-Laterriere, M, Daly, RJ, Sutherland, RL, Grimmond, SM, Waddell, N, Kassahn, KS, Miller, DK, Wilson, PJ, Patch, AM, Song, S, Harliwong, I, Idrisoglu, S, Nourbakhsh, E, Manning, S, Wani, S, Gongora, M, Anderson, M, Holmes, O, and Leonard, C

Abstract

Background & Aims: Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication stress, and novel therapeutic response in PC to develop a biomarker-driven therapeutic strategy targeting DDR and replication stress in PC. Methods: We interrogated the transcriptome, genome, proteome, and functional characteristics of 61 novel PC patient–derived cell lines to define novel therapeutic strategies targeting DDR and replication stress. Validation was done in patient-derived xenografts and human PC organoids. Results: Patient-derived cell lines faithfully recapitulate the epithelial component of pancreatic tumors, including previously described molecular subtypes. Biomarkers of DDR deficiency, including a novel signature of homologous recombination deficiency, cosegregates with response to platinum (P <.001) and PARP inhibitor therapy (P <.001) in vitro and in vivo. We generated a novel signature of replication stress that predicts response to ATR (P <.018) and WEE1 inhibitor (P <.029) treatment in both cell lines and human PC organoids. Replication stress was enriched in the squamous subtype of PC (P <.001) but was not associated with DDR deficiency. Conclusions: Replication stress and DDR deficiency are independent of each other, creating opportunities for therapy in DDR-proficient PC and after platinum therapy.

Published
2021

9. DNA sequencing on a chip

Author

Wallraff, G., Labadie, J., Brock, P., DiPietro, R., Nguyen, T., Huynh, T., Hinsberg, W., and McGall, G.

Subjects
DNA sequencers -- Innovations, Photolithography -- Usage, Photoresists -- Usage, Chemicals, plastics and rubber industries, Chemistry
Abstract

A combination of semiconductor photolithography with DNA sequencing technology gives high-density oligonucleotide arrays that provide rapid access to large scale genetic information. The desired arrays may be obtained using either polymeric photoresists or photogenerated acids. The photoresist process uses standard dimethoxytrityl (DMT) -protected nucleoside phosphoramidites along with traditional semiconductor lithography tools. The use of photogenerated acid in solid polymer thin-film matrices provides spatially directed detritylation of DMT-protected oligonucleotides.

Published
1997

12. Performance evaluation of hyperspectral detection algorithms for sub-pixel objects

Author

Lincoln Laboratory, Lockwood, Ronald B., Manolakis, Dimitris G., DiPietro, R. S., Cooley, T., Jacobson, J., Lincoln Laboratory, Lockwood, Ronald B., Manolakis, Dimitris G., DiPietro, R. S., Cooley, T., and Jacobson, J.

Abstract

One of the fundamental challenges for a hyperspectral imaging surveillance system is the detection of sub-pixel objects in background clutter. The background surrounding the object, which acts as interference, provides the major obstacle to successful detection. Two additional limiting factors are the spectral variabilities of the background and the object to be detected. In this paper, we evaluate the performance of detection algorithms for sub-pixel objects using a replacement signal model, where the spectral variability is modeled by multivariate normal distributions. The detection algorithms considered are the classical matched filter, the matched filter with false alarm mitigation, the mixture tuned matched filter and the finite target matched filter. These algorithms are compared using simulated and actual hyperspectral imaging data., United States. Dept. of Defense (Air Force Contract FA8721-05-C-0002)

Published
2011

13. Admittance spectroscopy of polymer-nanoparticle non-volatile memory devices

Author

Simon, Daniel, Griffo, Michael, DiPietro, R. A., Swanson, S. A., Carter, Sue, Simon, Daniel, Griffo, Michael, DiPietro, R. A., Swanson, S. A., and Carter, Sue

Abstract

Nonvolatile resistive memory consisting of gold nanoparticles embedded in the conducting polymer poly(4-n-hexylphenyldiphenylamine) examined using admittance spectroscopy. The frequency dependence of the devices indicates space-charge-limited transport in the high-conductivity "on" state, as well as evidence for similar transport in the lower-conductivity "off" state. Furthermore, the larger dc capacitance of the on state indicates that a greater amount of filling of the midgap nanoparticle trap levels increases the overall device conductivity, leading to the memory effect.

Published
2006
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19. Probe-based ultrahigh-density storage technology

Author

Pantazi, A., primary, Sebastian, A., additional, Antonakopoulos, T. A., additional, Bächtold, P., additional, Bonaccio, A. R., additional, Bonan, J., additional, Cherubini, G., additional, Despont, M., additional, DiPietro, R. A., additional, Drechsler, U., additional, Dürig, U., additional, Gotsmann, B., additional, Häberle, W., additional, Hagleitner, C., additional, Hedrick, J. L., additional, Jubin, D., additional, Knoll, A., additional, Lantz, M. A., additional, Pentarakis, J., additional, Pozidis, H., additional, Pratt, R. C., additional, Rothuizen, H., additional, Stutz, R., additional, Varsamou, M., additional, Wiesmann, D., additional, and Eleftheriou, E., additional

Published
2008
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24. First Example of a Nanoporous High‐Temperature Polymer Thermoset: Eluding Transition–Time–Temperature Constraints Associated with Organic Thermosets

Author

Connor, E. F., primary, Lee, V. Y., additional, Magbitang, T., additional, Hawker, C. J., additional, Volksen, W., additional, Siemens, R., additional, DiPietro, R. A., additional, Hedrick, J. C., additional, Kim, H. C., additional, Miller, R. D., additional, and Hedrick, J. L., additional

Published
2004
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25. Etch Selectivity of 4SiMA:Hydroxystyrene Based Copolymers. Silicon Chemistry for Bilayer Resist Systems.

Author

Wallraff, G. M., primary, Larson, C. E., additional, Sooriyakumaran, R., additional, Opitz, J., additional, Fenzel-Alexander, D., additional, DiPietro, R., additional, Hofer, D., additional, Breyta, G., additional, Sherwood, M., additional, Muete, J., additional, Lin, Q., additional, LaTulip, D., additional, Simons, J., additional, Babich, K., additional, Petrillo, K., additional, and Angelopoulos, M., additional

Published
1998
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32. Progress in 193 nm Positive Resists.

Author

ALLEN, R. D., primary, SOORIYAKUMARAN, R., additional, OPITZ, J., additional, WALLRAFF, G. M., additional, BREYTA, G., additional, DIPIETRO, R. A., additional, HOFER, D. C., additional, KUNZ, R. R., additional, OKOROANYANWU, U., additional, and WILLSON, C. G., additional

Published
1996
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34. Polyimide Nanofoams For Low Dielectric Applications

Author

Carter, K. R., primary, Cha, H. J., additional, Dipietro, R. A., additional, Hawker, C. J., additional, Hedrick, J. L., additional, Labadie, J. W., additional, Mcgrath, J. E., additional, Russell, T. P., additional, Sanchez, M. I., additional, Swanson, S. A., additional, Volksen, W., additional, and Yoon, D. Y., additional

Published
1995
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40. Mechanistic Studies of the Acidolysis Reactions Occurring in Silicon-Containing Bilayer Photoresists

Author

Zharov, I., Michl, J., Sherwood, M. H., Sooriyakamaran, R., Larson, C. E., DiPietro, R. A., Breyta, G., and Wallraff, G. M.

Abstract

As the feature sizes of semiconductor devices continue to shrink, there is an increasing interest in thin film imaging approaches such as silicon-based bilayer resists. We have developed such a resist based on a copolymer of 4-hydroxystyrene with a silicon-containing monomer, which functions simultaneously as the acid-sensitive component and a source of O2 etch resistance. In an attempt to understand the reactions that occur in the photoresist film, the acidolysis reactions of the 2-[tris(trimethylsilyl)silyl]ethyl moiety have been studied in solution. Acid-catalyzed cleavage of the model 2-trimethylsilylethyl acetate in solution proceeds via a nucleophilic attack on the silicon atom of the protonated acetate. Protonation of 2-[tris(trimethylsilyl)silyl]ethyl acetate is postulated to lead to a bridged siliconium cation, which reacts with nucleophiles along three pathways and yields products in which a nucleophile is attached to a silicon atom. This mechanism is consistent with the silylation of phenolic hydroxyl groups in the photoresist film consisting of a copolymer of 4-hydroxystyrene with 2-[tris(trimethylsilyl)silyl]ethyl methacrylate, observed during photolithographic processing.

Published
2002
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41. Nanoporous Polyimides Derived from Highly Fluorinated Polyimide/Poly(propylene Oxide) Copolymers

Author

Carter, K. R., DiPietro, R. A., Sanchez, M. I., and Swanson, S. A.

Abstract

Porous, low dielectric constant polyimide films have been made by a “nanofoam” approach. The pore sizes generated in the polymer films are in the tens of nanometers range, hence the term “nanofoams”. The nanoporous foams are generated by preparing triblock copolymers with the majority phase comprising polyimide and the minor phase consisting of a thermally labile block. Films of the copolymers are cast and then heated to effect solvent removal and annealing, resulting in microphase separation of the two dissimilar blocks. The labile blocks are selectively removed via thermal treatments, leaving pores the size and shape of the original copolymer morphology. The polyimide derived from 2,2-bis(4-aminophenyl)hexafluoropropane (6FDAm) and 9,9-bis(trifluoromethyl)xanthenetetracarboxylic dianhydride (6FXDA) was used as the matrix material for the generation of nanofoams, and specially functionalized poly(propylene oxide) oligomers were used as the thermally labile constituent. The synthesis and characterization of the copolymers were performed and the process for obtaining nanofoams was optimized. The foams were characterized by a variety of techniques including thermal gravimetric analysis (TGA), transmission electron microscopy (TEM), dynamic mechanical thermal analysis (DMTA), density, small-angle X-ray scattering (SAXS), refractive index, and dielectric constant measurements. Thin-film, high-modulus nanoporous films with good mechanical properties and dielectric constants ~2.3 have been synthesized by the copolymer/nanofoam approach.

Published
2001

44. Polyimide Nanofoams Based on Ordered Polyimides Derived from Poly(amic alkyl esters):  PMDA/4-BDAF

Author

Carter, K. R., DiPietro, R. A., Sanchez, M. I., Russell, T. P., Lakshmanan, P., and McGrath, J. E.

Abstract

A means of generating foams of high-temperature polymers, polyimides, has been developed for use in dielectric layers in microelectronics. In these systems, the pore sizes generated are in the tens of nanometers range, thus the term “nanofoams”. The foams are generated by preparing phase-separated block copolymers with the majority phase comprised of polyimide and the minor phase consisting of a thermally labile block. Films are cast, solvent is removed, and the copolymers are cured, causing phase separation of the two blocks. The labile blocks are subsequently removed via thermal treatments leaving pores having a size and shape commensurate with the size and shape of the original copolymer morphology. The polyimide derived from pyromellitic dianhydride (PMDA) and 2,2-bis[4-(4-aminophenoxy)phenyl]hexafluoropropane (4-BDAF) was used as the matrix materials for the generation of nanofoams, and poly(propylene oxide) oligomers were used as the thermally labile constituent. The synthesis and characterization of the copolymers were performed, and the process for obtaining nanofoams was optimized. The foams were characterized by a variety of techniques including TEM, SAXS, WAXD, DMTA, density, and refractive index measurements. Thin-film, high-modulus foams with good mechanical properties can be synthesized using the copolymer/nanofoam approach.

Published
1997

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