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Fifty strains of Branhamella catarrhalis were examined for susceptibility to sulphamethoxazole, trimethoprim and a combination of the two by determinating minimum inhibitory concentrations (MICs) and fractional inhibitory concentrations (FICs). All strains were susceptible to sulphamethoxazole and resistant to trimethoprim. On the basis of the MIC results it was predicted that greater synergy between sulphamethoxazole and trimethoprim would be observed with approximately equal proportions of each component. The lowest FIC values were obtained with a ratio of 1:1 and the greatest synergy was observed at this ratio with 39 strains (78%). Only seven strains were most synergistically inhibited at the ratio of 20:1 (sulphamethoxazole: trimethoprim) although this ratio was still synergic for most strains. Overall the 1:20 ratio was not synergic. [ABSTRACT FROM AUTHOR]

Aims: Many advocate screw fixation of fractures to the metaphyseal-diaphyseal junction of the fifth metatarsal base, better known as Jones fractures (JF), to facilitate quicker ambulation and return to sport. Maximizing screw parameters based on fifth metatarsal (MT5) anatomy, alongside understanding the anatomic structures compromised by screw insertion, may optimize surgical outcomes. This study aims to (1) correlate the proximity of JF to the peroneus brevis (PB) and plantar fascia (PF) footprints and (2) quantify optimal screw parameters given MT5 anatomy.Materials and Methods: 3D CT-scan reconstructions were made of 21 cadaveric MT5s, followed by meticulous mapping of the PB and PF onto the reconstructions. Based on bone length, shape, narrowest intramedullary canal (IMC) diameter, and surrounding anatomy, two traditional debated screw positions were modeled for each reconstruction: (1) an anatomically positioned screw (AP), predicated on maximizing screw length by following the IMC for as long as possible, and (2) a clinically achievable screw (CA), predicated on maximizing screw length without violating the fifth tarso-metatarsal joint or adjacent cuboid bone. Fixation parameters were calculated for all models.Results: The PB and PF extended into the JF site in 29% and 43%, respectively. AP's did not affect PB and PF footprint but required screw entry through the cuboid and fifth tarso-metatarsal joint in all specimens. CA screw entry sites, avoiding the cuboid and fifth tarso-metatarsal joint, partially compromised the PB and PF insertions in 33% and 62% with a median surface loss of 1.6%%(range 0.2-3.2%) and 0.81%%(range 0.05-1.6%), respectively. Mean AP screw length was 64±3.6mm and thread length 49±4.2mm. Mean CA screw length was 48±5.8mm and thread length 28±6.9mm.Conclusion: This study underscores the challenges associated with surrounding MT5 anatomy as they relate to optimal JF treatment. Both the extent of JF as well as a clinically achievable positioned screw violate the PB and PF footprints - although the degree to which even partial disruption of these footprints has on outcome remains unclear. To minimize damage to surrounding structures, including the PB and PF footprint, while allowing a screw length approximately two thirds of the metatarsal length, the CA screw position is recommended. This position balances the desire to maximize pull out strength while avoiding cortical penetration or inadvertent fracture site distraction. [ABSTRACT FROM AUTHOR]

The current research aims to investigate whether perspective taking influences social tuning, or the alignment of one's self-views, explicit attitudes, and/or implicit attitudes with those of an interaction partner. In six different experiments, participants believed they would interact with a partner to complete a task. Prior to this ostensible interaction, participants were given a perspective taking mindset prime, or not, and information about their ostensible interaction partners views. Participants then completed attitude measures related to the partner's perceived views. Experiments 1a, 1b, and 2 examined whether perspective taking with an ostensible interaction partner who endorses gender traditional (or non-traditional) views align their self-views with this partner, including implicit self-views (Experiment 2). Experiments 3-5 investigated whether perspective taking leads to social tuning for egalitarian racial attitudes, including when the partner's expectations of how others will be and when the participant learns their ostensible IAT score at the beginning of the session. We predicted perspective takers would be more likely to social tune their explicit and implicit attitudes to the attitudes of their interaction partner than non-perspective takers. Across all experiments, perspective takers were more likely to social tune their self-views and explicit attitudes than non-perspective takers. However, social tuning never occurred for implicit attitudes. Thus, future research is needed to understand why perspective taking does not influence the tuning of implicit attitudes, but other motivations, like affiliative and epistemic, do., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Skorinko, DiGiovanni, Rondina, Tavares, Spinney, Kobeissi, Lacera, Vega, Beatty, John and Doyle.)