1. Determinant of Prenatal Diagnostic Testing among Women with Increased Risk of Fetal Aneuploidy and Genetic Disorders.
- Author
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Tan, Catherine, Della-Torre, Micaela, Jackson-Bey, Tia, DiGiovanni, Laura, Enakpene, Christopher, and Morgan, Tamandra
- Subjects
Pregnancy ,Humans ,Female ,Retrospective Studies ,Aneuploidy ,Down Syndrome ,Nuchal Translucency Measurement ,Fetus ,Prenatal Diagnosis ,Ultrasonography ,Prenatal ,Genetic Testing - Abstract
OBJECTIVE: This study aimed to assess factors that influence patients decisions in accepting prenatal diagnostic testing following genetic counseling for increased risk of fetal aneuploidy. METHODS: This is a retrospective cohort study of women at increased risk of fetal aneuploidy and genetic disorders who had genetic counseling from January 2012 to December 2016 at a single academic center. Demographics, indications for genetic counseling, and rates of diagnostic testing were collected and compared between those who accepted diagnostic testing and those who chose cell free DNA. The variables were analyzed using Chi-square, Fishers exact test, and multiple logistic regression. RESULT: Of the 2,373 pregnant women who underwent genetic counseling for increased risk of fetal aneuploidy and genetic disorders during the study period, 321 women had diagnostic testing (13.5%). Women at 35 years and older accepted diagnostic testing more than women younger than 35 years (20.7 vs. 11.5%, p
- Published
- 2024