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1. Global position paper on cardiovascular regenerative medicine

Author

Fernández-Avilés, Francisco, Sanz-Ruiz, Ricardo, Climent, Andreu M, Badimon, Lina, Bolli, Roberto, Charron, Dominique, Fuster, Valentin, Janssens, Stefan, Kastrup, Jens, Kim, Hyo-Soo, Lüscher, Thomas F, Martin, John F, Menasché, Philippe, Simari, Robert D, Stone, Gregg W, Terzic, Andre, Willerson, James T, Wu, Joseph C, Group, the TACTICS Writing, Broughton, Kathleen, DiFede, Darcy L, Dimmeler, Stefanie, Madonna, Rosalinda, Penn, Marc S, Sussman, Mark A, Sluijter, Joost PG, Wollert, Kai C, Balkan, Wayne, Chamuleau, Steven, Fernández-Santos, María Eugenia, Goliasch, Georg, Gyöngyösi, Mariann, Hare, Joshua M, Tompkins, Bryon A, Winkler, Johannes, Bayés-Genís, Antoni, Henry, Timothy D, Taylor, Doris A, Lerman, Amir, Pelacho, Beatriz, Prosper, Felipe, Perin, Emerson C, Pompilio, Giulio, Gersh, Bernard, Bartunek, Jozef, Duckers, Eric, Ferdinandy, Péter, Losordo, Douglas W, Sánchez, Pedro L, Sherman, Warren, Wojakowski, Wojtek, Zeiher, Andreas, Roncalli, Jerome, Mathur, Anthony, Crea, Filippo, D´Amario, Domenico, Povsic, Thomas J, Traverse, Jay, and Ylä-Herttuala, Seppo

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Cardiovascular Diseases, Consensus, Humans, Precision Medicine, Regenerative Medicine, TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) Writing Group, Authors/Task Force Members. Chairpersons, Basic Research Subcommittee, Translational Research Subcommittee, Challenges of Cardiovascular Regenerative Medicine Subcommittee, Tissue Engineering Subcommittee, Delivery, Navigation, Tracking and Assessment Subcommittee, Clinical Trials Subcommittee, Regulatory and funding strategies subcommittee, Delivery, Navigation, Tracking and Assessment Subcommittee, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Published
2017

4. Rationale and Design of the CONCERT-HF Trial (Combination of Mesenchymal and c-kit+ Cardiac Stem Cells As Regenerative Therapy for Heart Failure)

Author

Bolli, Roberto, Hare, Joshua M., March, Keith L., Pepine, Carl J., Willerson, James T., Perin, Emerson C., Yang, Phillip C., Henry, Timothy D., Traverse, Jay H., Mitrani, Raul D., Khan, Aisha, Hernandez-Schulman, Ivonne, Taylor, Doris A., DiFede, Darcy L., Lima, João A.C., Chugh, Atul, Loughran, John, Vojvodic, Rachel W., Sayre, Shelly L., Bettencourt, Judy, Cohen, Michelle, Moyé, Lem, Ebert, Ray F., and Simari, Robert D.

Published
2018
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6. Dose Comparison Study of Allogeneic Mesenchymal Stem Cells in Patients With Ischemic Cardiomyopathy (The TRIDENT Study)

Author

Florea, Victoria, Rieger, Angela C., DiFede, Darcy L., El-Khorazaty, Jill, Natsumeda, Makoto, Banerjee, Monisha N., Tompkins, Bryon A., Khan, Aisha, Schulman, Ivonne H., Landin, Ana Marie, Mushtaq, Muzammil, Golpanian, Samuel, Lowery, Maureen H., Byrnes, John J., Hendel, Robert C., Cohen, Mauricio G., Valasaki, Krystalenia, Pujol, Marietsy V., Ghersin, Eduard, Miki, Roberto, Delgado, Cindy, Abuzeid, Fouad, Vidro-Casiano, Mayra, Saltzman, Russell G., DaFonseca, Daniel, Caceres, Lina V., Ramdas, Kevin N., Mendizabal, Adam, Heldman, Alan W., Mitrani, Raul D., and Hare, Joshua M.

Published
2017
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7. Allogeneic Human Mesenchymal Stem Cell Infusions for Aging Frailty

Author

Golpanian, Samuel, DiFede, Darcy L, Khan, Aisha, Schulman, Ivonne Hernandez, Landin, Ana Marie, Tompkins, Bryon A, Heldman, Alan W, Miki, Roberto, Goldstein, Bradley J, Mushtaq, Muzammil, Levis-Dusseau, Silvina, Byrnes, John J, Lowery, Maureen, Natsumeda, Makoto, Delgado, Cindy, Saltzman, Russell, Vidro-Casiano, Mayra, Pujol, Marietsy V, Da Fonseca, Moisaniel, Oliva, Anthony A, Jr, Green, Geoff, Premer, Courtney, Medina, Audrey, Valasaki, Krystalenia, Florea, Victoria, Anderson, Erica, El-Khorazaty, Jill, Mendizabal, Adam, Goldschmidt-Clermont, Pascal J, and Hare, Joshua M

Published
2017
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8. Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Author

Tompkins, Bryon A, DiFede, Darcy L, Khan, Aisha, Landin, Ana Marie, Schulman, Ivonne Hernandez, Pujol, Marietsy V, Heldman, Alan W, Miki, Roberto, Goldschmidt-Clermont, Pascal J, Goldstein, Bradley J, Mushtaq, Muzammil, Levis-Dusseau, Silvina, Byrnes, John J, Lowery, Maureen, Natsumeda, Makoto, Delgado, Cindy, Saltzman, Russell, Vidro-Casiano, Mayra, Da Fonseca, Moisaniel, Golpanian, Samuel, Premer, Courtney, Medina, Audrey, Valasaki, Krystalenia, Florea, Victoria, Anderson, Erica, El-Khorazaty, Jill, Mendizabal, Adam, Green, Geoff, Oliva, Anthony A, and Hare, Joshua M

Published
2017
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9. Rationale and Design of the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis in Dilated Cardiomyopathy (The POSEIDON-DCM Study): A phase I/II, Randomized Pilot Study of the Comparative Safety and Efficacy of Transendocardial Injection of Autologous Mesenchymal Stem Cell vs. Allogeneic Mesenchymal Stem Cells in Patients with Non-ischemic Dilated Cardiomyopathy

Author

Mushtaq, Muzammil, DiFede, Darcy L., Golpanian, Samuel, Khan, Aisha, Gomes, Samirah A., Mendizabal, Adam, Heldman, Alan W., and Hare, Joshua M.

Published
2014
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10. The Interdisciplinary Stem Cell Institute’s Use of Food and Drug Administration-Expanded Access Guidelines to Provide Experimental Cell Therapy to Patients With Rare Serious Diseases

Author

Khan, Aisha, primary, Bellio, Michael A., additional, Schulman, Ivonne H., additional, Levi, Allan D., additional, Longsomboon, Bangon, additional, Brooks, Adriana, additional, Valasaki, Krystalenia, additional, DiFede, Darcy L., additional, Pujol, Marietsy V., additional, Yavagal, Dileep R., additional, Bates, Karen E., additional, Si, Ming-Sing, additional, Kaushal, Sunjay, additional, Green, Barth A., additional, Anderson, Kimberly D., additional, Guest, James D., additional, Burks, Stephen Shelby, additional, Silvera, Risset, additional, Santamaria, Andrea J., additional, Lalwani, Anil, additional, Dietrich, W. Dalton, additional, and Hare, Joshua M., additional

Published
2021
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11. Pregnancy, a unique case of heterochronic parabiosis and peripartum cardiomyopathy.

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'obstétrique, Goldschmidt-Clermont, Pascal J, Hubinont, Corinne, Goldschmidt, Alexander J P, DiFede, Darcy L, White, Ian A, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'obstétrique, Goldschmidt-Clermont, Pascal J, Hubinont, Corinne, Goldschmidt, Alexander J P, DiFede, Darcy L, and White, Ian A

Abstract

A loss of endogenous stem cells capable of tissue repair and regeneration drives the biological process that we recognize as "aging". Recovery of stem cell-mediated repair and regenerative functions in aged animals has been reported in murine heterochronic parabiosis experiments. : Herein we will review how pregnancy is an unusual form of heterochronic parabiosis, as the placenta prevents the exchange of most blood cells between parabionts. Instead, plasma and its content, including small extracellular vesicles, can readily cross the placental barrier. These nanosized extracellular vesicles are readily produced by the placenta, amnion, fetus and mother, and are essential for fetal organogenesis, growth and the progression of a healthy pregnancy. If defective, these extracellular vesicles can cause havoc such as in the case of peripartum cardiomyopathy. We will also review how these extracellular vesicles impact the mother substantially (including cardiac function) in the parabiosis of pregnancy. : Extracellular vesicles generated during the course of a healthy pregnancy are essential for organogenesis and fetal growth, and also for maternal tissue repair and regeneration, and might be defective or deficient in pregnancies that result in peripartum cardiomyopathy.

Published
2021

12. Transendocardial Mesenchymal Stem Cells and Mononuclear Bone Marrow Cells for Ischemic Cardiomyopathy: The TAC-HFT Randomized Trial

Author

Heldman, Alan W., DiFede, Darcy L., Fishman, Joel E., Zambrano, Juan P., Trachtenberg, Barry H., Karantalis, Vasileios, Mushtaq, Muzammil, Williams, Adam R., Suncion, Viky Y., McNiece, Ian K., Ghersin, Eduard, Soto, Victor, Lopera, Gustavo, Miki, Roberto, Willens, Howard, Hendel, Robert, Mitrani, Raul, Pattany, Pradip, Feigenbaum, Gary, Oskouei, Behzad, Byrnes, John, Lowery, Maureen H., Sierra, Julio, Pujol, Mariesty V., Delgado, Cindy, Gonzalez, Phillip J., Rodriguez, Jose E., Bagno, Luiza Lima, Rouy, Didier, Altman, Peter, Foo, Cheryl Wong Po, da Silva, Jose, Anderson, Erica, Schwarz, Richard, Mendizabal, Adam, and Hare, Joshua M.

Published
2014
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13. Genetic determinants of responsiveness to mesenchymal stem cell injections in non-ischemic dilated cardiomyopathy

Author

Rieger, Angela C., primary, Myerburg, Robert J., additional, Florea, Victoria, additional, Tompkins, Bryon A., additional, Natsumeda, Makoto, additional, Premer, Courtney, additional, Khan, Aisha, additional, Schulman, Ivonne H., additional, Vidro-Casiano, Mayra, additional, DiFede, Darcy L., additional, Heldman, Alan W., additional, Mitrani, Raul, additional, and Hare, Joshua M., additional

Published
2019
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16. Randomized Comparison of Allogeneic Vs. Autologous Mesenchymal Stem Cells for Non-lschemic Dilated Cardiomyopathy: POSEIDON-DCM Trial

Author

Hare, Joshua M., DiFede, Darcy L., Castellanos, Angela M., Florea, Victoria, Landin, Ana M., El-Khorazaty, Jill, Khan, Aisha, Mushtaq, Muzammil, Lowery, Maureen H., Byrnes, John J., Hendel, Robert C., Cohen, Mauricio G., Alfonso, Carlos E., Valasaki, Krystalenia, Pujol, Marietsy V., Golpanian, Samuel, Ghersin, Eduard, Fishman, Joel E., Pattany, Pradip, Gomes, Samirah A., Delgado, Cindy, Miki, Roberto, Abuzeid, Fouad, Vidro-Casiano, Mayra, Premer, Courtney, Medina, Audrey, Porras, Valeria, Hatzistergos, Konstantinos E., Anderson, Erica, Mendizabal, Adam, Mitrani, Raul, and Heldman, Alan W.

Subjects
Cardiology and Cardiovascular Medicine
Published
2016
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18. Rationale and Design of the CONCERT-HF Trial (Combination of Mesenchymal and c-kit + Cardiac Stem Cells As Regenerative Therapy for Heart Failure)

Author

Bolli, Roberto, primary, Hare, Joshua M., additional, March, Keith L., additional, Pepine, Carl J., additional, Willerson, James T., additional, Perin, Emerson C., additional, Yang, Phillip C., additional, Henry, Timothy D., additional, Traverse, Jay H., additional, Mitrani, Raul D., additional, Khan, Aisha, additional, Hernandez-Schulman, Ivonne, additional, Taylor, Doris A., additional, DiFede, Darcy L., additional, Lima, João A.C., additional, Chugh, Atul, additional, Loughran, John, additional, Vojvodic, Rachel W., additional, Sayre, Shelly L., additional, Bettencourt, Judy, additional, Cohen, Michelle, additional, Moyé, Lem, additional, Ebert, Ray F., additional, and Simari, Robert D., additional

Published
2018
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19. Global position paper on cardiovascular regenerative medicine

Author

Planningssecretariaat HCK, UMC Utrecht, Onderzoek Cardiovasculair Reg. Med., Circulatory Health, Regenerative Medicine and Stem Cells, Cardiologie, Team Medisch, Aios en Stafsecr. Cardiologie, Fernández-Avilés, Francisco, Sanz-Ruiz, Ricardo, Climent, Andreu M., Badimon, Lina, Bolli, Roberto, Charron, Dominique, Fuster, Valentin, Janssens, Stefan, Kastrup, Jens, Kim, Hyo Soo, Lüscher, Thomas Felix, Martin, John F., Menasche, Philippe, Simari, Robert D., Stone, Gregg W., Terzic, Andre, Willerson, James T., Wu, Joseph C., Joseph, C. Wu, Broughton, Kathleen, DiFede, Darcy L., Dimmeler, Stefanie, Madonna, Rosalinda, Penn, Marc S., Sussman, Mark A., Sluijter, Joost P.G., Woller, Kai C., Balkan, Wayne, Chamuleau, Steven, Fernández-Santos, Maria Eugenia, Goliasch, Georg, Gyöngyösi, Mariann, Hare, Joshua M., Tompkins, Bryon A., Winkler, Johannes, Bayés-Genis, Antoni, Henry, Timothy D., Taylor, Doris A., Lerman, Amir, Pelacho, Beatriz, Prosper, Felipe, Perin, Emerson C., Pompilio, Giulio, Gersh, Bernard, Bartunek, Jozef, Duckers, Eric, Ferdinandy, Péter, Losordo, Douglas W., Čanchez, Pedro L., Sherman, Warren, Wojakowski, Wojtek, Zeiher, Andreas, Roncalli, Jerome, Mathur, Anthony, Crea, Filippo, D'Amario, Domenico, Povsic, Thomas J., Traverse, Jay, Yla-Herttuala, Seppo, Planningssecretariaat HCK, UMC Utrecht, Onderzoek Cardiovasculair Reg. Med., Circulatory Health, Regenerative Medicine and Stem Cells, Cardiologie, Team Medisch, Aios en Stafsecr. Cardiologie, Fernández-Avilés, Francisco, Sanz-Ruiz, Ricardo, Climent, Andreu M., Badimon, Lina, Bolli, Roberto, Charron, Dominique, Fuster, Valentin, Janssens, Stefan, Kastrup, Jens, Kim, Hyo Soo, Lüscher, Thomas Felix, Martin, John F., Menasche, Philippe, Simari, Robert D., Stone, Gregg W., Terzic, Andre, Willerson, James T., Wu, Joseph C., Joseph, C. Wu, Broughton, Kathleen, DiFede, Darcy L., Dimmeler, Stefanie, Madonna, Rosalinda, Penn, Marc S., Sussman, Mark A., Sluijter, Joost P.G., Woller, Kai C., Balkan, Wayne, Chamuleau, Steven, Fernández-Santos, Maria Eugenia, Goliasch, Georg, Gyöngyösi, Mariann, Hare, Joshua M., Tompkins, Bryon A., Winkler, Johannes, Bayés-Genis, Antoni, Henry, Timothy D., Taylor, Doris A., Lerman, Amir, Pelacho, Beatriz, Prosper, Felipe, Perin, Emerson C., Pompilio, Giulio, Gersh, Bernard, Bartunek, Jozef, Duckers, Eric, Ferdinandy, Péter, Losordo, Douglas W., Čanchez, Pedro L., Sherman, Warren, Wojakowski, Wojtek, Zeiher, Andreas, Roncalli, Jerome, Mathur, Anthony, Crea, Filippo, D'Amario, Domenico, Povsic, Thomas J., Traverse, Jay, and Yla-Herttuala, Seppo

Published
2017

20. Study design and rationale for ELPIS: A phase I/IIb randomized pilot study of allogeneic human mesenchymal stem cell injection in patients with hypoplastic left heart syndrome

Author

Kaushal, Sunjay, primary, Wehman, Brody, additional, Pietris, Nicholas, additional, Naughton, Casey, additional, Bentzen, Soren M., additional, Bigham, Grace, additional, Mishra, Rachana, additional, Sharma, Sudhish, additional, Vricella, Luca, additional, Everett, Allen D., additional, Deatrick, Kristopher B., additional, Huang, Sihong, additional, Mehta, Helina, additional, Ravekes, William A., additional, Hibino, Naru, additional, Difede, Darcy L., additional, Khan, Aisha, additional, and Hare, Joshua M., additional

Published
2017
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22. Effects of Transendocardial Stem Cell Injection on Ventricular Proarrhythmia in Patients with Ischemic Cardiomyopathy: Results from the POSEIDON and TAC-HFT Trials

Author

Ramireddy, Archana, primary, Brodt, Chad R., additional, Mendizabal, Adam M., additional, DiFede, Darcy L., additional, Healy, Chris, additional, Goyal, Vishal, additional, Alansari, Yahya, additional, Coffey, James O., additional, Viles-Gonzalez, Juan F., additional, Heldman, Alan W., additional, Goldberger, Jeffrey J., additional, Myerburg, Robert J., additional, Hare, Joshua M., additional, and Mitrani, Raul D., additional

Published
2017
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23. Randomized Comparison of Allogeneic Versus Autologous Mesenchymal Stem Cells for Nonischemic Dilated Cardiomyopathy

Author

Hare, Joshua M., primary, DiFede, Darcy L., additional, Rieger, Angela C., additional, Florea, Victoria, additional, Landin, Ana M., additional, El-Khorazaty, Jill, additional, Khan, Aisha, additional, Mushtaq, Muzammil, additional, Lowery, Maureen H., additional, Byrnes, John J., additional, Hendel, Robert C., additional, Cohen, Mauricio G., additional, Alfonso, Carlos E., additional, Valasaki, Krystalenia, additional, Pujol, Marietsy V., additional, Golpanian, Samuel, additional, Ghersin, Eduard, additional, Fishman, Joel E., additional, Pattany, Pradip, additional, Gomes, Samirah A., additional, Delgado, Cindy, additional, Miki, Roberto, additional, Abuzeid, Fouad, additional, Vidro-Casiano, Mayra, additional, Premer, Courtney, additional, Medina, Audrey, additional, Porras, Valeria, additional, Hatzistergos, Konstantinos E., additional, Anderson, Erica, additional, Mendizabal, Adam, additional, Mitrani, Raul, additional, and Heldman, Alan W., additional

Published
2017
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24. Autologous Mesenchymal Stem Cells Produce Concordant Improvements in Regional Function, Tissue Perfusion and Fibrotic Burden when Administered to Patients Undergoing Coronary Artery Bypass Grafting – The PROMETHEUS Trial

Author

Karantalis, Vasileios, DiFede, Darcy L., Gerstenblith, Gary, Pham, Si, Symes, James, Zambrano, Juan Pablo, Fishman, Joel, Pattany, Pradip, McNiece, Ian, Conte, John, Schulman, Steven, Wu, Katherine, Shah, Ashish, Breton, Elayne, Davis-Sproul, Janice, Schwarz, Richard, Feigenbaum, Gary, Mushtaq, Muzammil, Suncion, Viky Y., Lardo, Albert C., Borrello, Ivan, Mendizabal, Adam, Karas, Tomer Z., Byrnes, John, Lowery, Maureen, Heldman, Alan W., and Hare, Joshua M.

Subjects
Male, Cicatrix, Ventricular Dysfunction, Left, Myocardium, Cell- and Tissue-Based Therapy, Myocardial Infarction, Myocardial Ischemia, Humans, Female, Coronary Artery Bypass, Cardiomyopathies, Mesenchymal Stem Cell Transplantation, Article
Published
2014

26. Rationale and design of the allogeneiC human mesenchymal stem cells (hMSC) in patients with aging fRAilTy via intravenoUS delivery (CRATUS) study: A phase I/II, randomized, blinded and placebo controlled trial to evaluate the safety and potential efficacy of allogeneic human mesenchymal stem cell infusion in patients with aging frailty

Author

Golpanian, Samuel, primary, DiFede, Darcy L., additional, Pujol, Marietsy V., additional, Lowery, Maureen H., additional, Levis-Dusseau, Silvina, additional, Goldstein, Bradley J., additional, Schulman, Ivonne H., additional, Longsomboon, Bangon, additional, Wolf, Ariel, additional, Khan, Aisha, additional, Heldman, Alan W., additional, Goldschmidt-Clermont, Pascal J., additional, and Hare, Joshua M., additional

Published
2016
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27. Synergistic Effects of Combined Cell Therapy for Chronic Ischemic Cardiomyopathy

Author

Karantalis, Vasileios, primary, Suncion-Loescher, Viky Y., additional, Bagno, Luiza, additional, Golpanian, Samuel, additional, Wolf, Ariel, additional, Sanina, Cristina, additional, Premer, Courtney, additional, Kanelidis, Anthony J., additional, McCall, Frederic, additional, Wang, Bo, additional, Balkan, Wayne, additional, Rodriguez, Jose, additional, Rosado, Marcos, additional, Morales, Azorides, additional, Hatzistergos, Konstantinos, additional, Natsumeda, Makoto, additional, Margitich, Irene, additional, Schulman, Ivonne Hernandez, additional, Gomes, Samirah A., additional, Mushtaq, Muzammil, additional, DiFede, Darcy L., additional, Fishman, Joel E., additional, Pattany, Pradip, additional, Zambrano, Juan Pablo, additional, Heldman, Alan W., additional, and Hare, Joshua M., additional

Published
2015
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28. Allogeneic Mesenchymal Stem Cells Restore Endothelial Function in Heart Failure by Stimulating Endothelial Progenitor Cells

Author

Premer, Courtney, primary, Blum, Arnon, additional, Bellio, Michael A., additional, Schulman, Ivonne Hernandez, additional, Hurwitz, Barry E., additional, Parker, Meela, additional, Dermarkarian, Christopher R., additional, DiFede, Darcy L., additional, Balkan, Wayne, additional, Khan, Aisha, additional, and Hare, Joshua M., additional

Published
2015
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29. Autologous Mesenchymal Stem Cells Produce Concordant Improvements in Regional Function, Tissue Perfusion, and Fibrotic Burden When Administered to Patients Undergoing Coronary Artery Bypass Grafting

Author

Karantalis, Vasileios, primary, DiFede, Darcy L., additional, Gerstenblith, Gary, additional, Pham, Si, additional, Symes, James, additional, Zambrano, Juan Pablo, additional, Fishman, Joel, additional, Pattany, Pradip, additional, McNiece, Ian, additional, Conte, John, additional, Schulman, Steven, additional, Wu, Katherine, additional, Shah, Ashish, additional, Breton, Elayne, additional, Davis-Sproul, Janice, additional, Schwarz, Richard, additional, Feigenbaum, Gary, additional, Mushtaq, Muzammil, additional, Suncion, Viky Y., additional, Lardo, Albert C., additional, Borrello, Ivan, additional, Mendizabal, Adam, additional, Karas, Tomer Z., additional, Byrnes, John, additional, Lowery, Maureen, additional, Heldman, Alan W., additional, and Hare, Joshua M., additional

Published
2014
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30. Abstract 9609: Impact of Mesenchymal Stem Cell Left Ventricular Implantation on Heart Rate Variability: Results From the POSEIDON Trial

Author

Shah, Sachil, primary, Brodt, Chad, additional, DiFede, Darcy L, additional, Ramireddy, Archana, additional, Coffey, James O, additional, Viles Gonzalez, Juan F, additional, Atapattu, Suresh, additional, Heldman, Alan W, additional, Myerburg, Robert J, additional, Hare, Joshua M, additional, and Mitrani, Raul D, additional

Published
2013
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32. Global position paper on cardiovascular regenerative medicine

Author

Fernández-Avilés, Francisco, Sanz-Ruiz, Ricardo, Climent, Andreu M., Badimon, Lina, Bolli, Roberto, Charron, Dominique, Fuster, Valentin, Janssens, Stefan, Kastrup, Jens, Kim, Hyo-Soo, Lüscher, Thomas F., Martin, John F., Menasché, Philippe, Simari, Robert D., Stone, Gregg W., Terzic, Andre, Willerson, James T., Wu, Joseph C., Broughton, Kathleen, DiFede, Darcy L., Dimmeler, Stefanie, Madonna, Rosalinda, Penn, Marc S., Sussman, Mark A., Sluijter, Joost P.G., Wollert, Kai C., Balkan, Wayne, Chamuleau, Steven, Fernández-Santos, María Eugenia, Goliasch, Georg, Gyöngyösi, Mariann, Hare, Joshua M., Tompkins, Bryon A., Winkler, Johannes, Bayés-Genís, Antoni, Henry, Timothy D., Taylor, Doris A., Lerman, Amir, Pelacho, Beatriz, Prosper, Felipe, Perin, Emerson C., Pompilio, Giulio, Gersh, Bernard, Bartunek, Jozef, Duckers, Eric, Ferdinandy, Péter, Losordo, Douglas W., Sánchez, Pedro L., Sherman, Warren, Wojakowski, Wojtek, Zeiher, Andreas, Roncalli, Jerome, Mathur, Anthony, Crea, Filippo, D´Amario, Domenico, Povsic, Thomas J., Traverse, Jay, Ylä-Herttuala, Seppo, Cardiology, University of Zurich, and Fernández-Avilés, Francisco

Subjects
0301 basic medicine, medicine.medical_specialty, Consensus, business.industry, Extramural, MEDLINE, 610 Medicine & health, 030204 cardiovascular system & hematology, Regenerative Medicine, Regenerative medicine, 2705 Cardiology and Cardiovascular Medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Cardiovascular Diseases, Current Opinion, Humans, Precision Medicine, 10209 Clinic for Cardiology, Position paper, Medicine, Medical physics, Cardiology and Cardiovascular Medicine, business
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34. Pregnancy, a unique case of heterochronic parabiosis and peripartum cardiomyopathy.

Author

Goldschmidt-Clermont PJ, Hubinont C, Goldschmidt AJP, DiFede DL, and White IA

Subjects
Aging, Animals, Female, Humans, Mice, Parabiosis, Placenta, Pregnancy, Cardiomyopathies, Peripartum Period
Abstract

Introduction : A loss of endogenous stem cells capable of tissue repair and regeneration drives the biological process that we recognize as "aging". Recovery of stem cell-mediated repair and regenerative functions in aged animals has been reported in murine heterochronic parabiosis experiments. Objectives : Herein we will review how pregnancy is an unusual form of heterochronic parabiosis, as the placenta prevents the exchange of most blood cells between parabionts. Instead, plasma and its content, including small extracellular vesicles, can readily cross the placental barrier. These nanosized extracellular vesicles are readily produced by the placenta, amnion, fetus and mother, and are essential for fetal organogenesis, growth and the progression of a healthy pregnancy. If defective, these extracellular vesicles can cause havoc such as in the case of peripartum cardiomyopathy. We will also review how these extracellular vesicles impact the mother substantially (including cardiac function) in the parabiosis of pregnancy. Conclusion : Extracellular vesicles generated during the course of a healthy pregnancy are essential for organogenesis and fetal growth, and also for maternal tissue repair and regeneration, and might be defective or deficient in pregnancies that result in peripartum cardiomyopathy., (© 2021 The Author(s). Published by BRI.)

Published
2021
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