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1. Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study

Author

Song, Honglin, Ramus, Susan J, Kjaer, Susanne Krüger, DiCioccio, Richard A, Chenevix-Trench, Georgia, Pearce, Celeste Leigh, Hogdall, Estrid, Whittemore, Alice S, McGuire, Valerie, Hogdall, Claus, Blaakaer, Jan, Wu, Anna H, Van Den Berg, David J, Stram, Daniel O, Menon, Usha, Gentry-Maharaj, Aleksandra, Jacobs, Ian J, Webb, Penny M, Beesley, Jonathan, Chen, Xiaoqing, Rossing, Mary Anne, Doherty, Jennifer A, Chang-Claude, Jenny, Wang-Gohrke, Shan, Goodman, Marc T, Lurie, Galina, Thompson, Pamela J, Carney, Michael E, Ness, Roberta B, Moysich, Kirsten, Goode, Ellen L, Vierkant, Robert A, Cunningham, Julie M, Anderson, Stephanie, Schildkraut, Joellen M, Berchuck, Andrew, Iversen, Edwin S, Moorman, Patricia G, Garcia-Closas, Montserrat, Chanock, Stephen, Lissowska, Jolanta, Brinton, Louise, Anton-Culver, Hoda, Ziogas, Argyrios, Brewster, Wendy R, Ponder, Bruce AJ, Easton, Douglas F, Gayther, Simon A, and Pharoah, Paul DP

Subjects
Biological Sciences, Genetics, Prevention, Human Genome, Ovarian Cancer, Clinical Research, Cancer, Breast Cancer, Aging, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Breast Neoplasms, Case-Control Studies, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Glycoproteins, Humans, Neuropeptides, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Risk Factors, White People, Australian Cancer (Ovarian) Study, Australian Ovarian Cancer Study Group, Ovarian Cancer Association Consortium, Medical and Health Sciences, Genetics & Heredity
Abstract

Because both ovarian and breast cancer are hormone-related and are known to have some predisposition genes in common, we evaluated 11 of the most significant hits (six with confirmed associations with breast cancer) from the breast cancer genome-wide association study for association with invasive ovarian cancer. Eleven SNPs were initially genotyped in 2927 invasive ovarian cancer cases and 4143 controls from six ovarian cancer case-control studies. Genotype frequencies in cases and controls were compared using a likelihood ratio test in a logistic regression model stratified by study. Initially, three SNPs (rs2107425 in MRPL23, rs7313833 in PTHLH, rs3803662 in TNRC9) were weakly associated with ovarian cancer risk and one SNP (rs4954956 in NXPH2) was associated with serous ovarian cancer in non-Hispanic white subjects (P-trend < 0.1). These four SNPs were then genotyped in an additional 4060 cases and 6308 controls from eight independent studies. Only rs4954956 was significantly associated with ovarian cancer risk both in the replication study and in combined analyses. This association was stronger for the serous histological subtype [per minor allele odds ratio (OR) 1.07 95% CI 1.01-1.13, P-trend = 0.02 for all types of ovarian cancer and OR 1.14 95% CI 1.07-1.22, P-trend = 0.00017 for serous ovarian cancer]. In conclusion, we found that rs4954956 was associated with increased ovarian cancer risk, particularly for serous ovarian cancer. However, none of the six confirmed breast cancer susceptibility variants we tested was associated with ovarian cancer risk. Further work will be needed to identify the causal variant associated with rs4954956 or elucidate its function.

Published
2009

2. BRAF polymorphisms and the risk of ovarian cancer of low malignant potential

Author

Kelemen, Livia, James, Michael, Spurdle, Amanda, Campbell, Ian, Chang-Claude, Jenny, Peel, David, Anton-Culver, Hoda, Berchuck, Andrew, Schildkraut, Joellen, Whittemore, Alice, McGurie, Valerie, DiCioccio, Richard A, Duffy, David, and Chenevix-Trench, Georgia

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Ovarian Cancer, Human Genome, Clinical Research, Cancer, Prevention, Genetics, Aetiology, 2.1 Biological and endogenous factors, Adult, Aged, Aged, 80 and over, Case-Control Studies, Cystadenocarcinoma, Serous, Female, Genetic Predisposition to Disease, Haplotypes, Humans, Middle Aged, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Proto-Oncogene Proteins B-raf, BRAF, susceptibility, polymorphism, ovarian cancer, low malignant potential, LMP, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis, Reproductive medicine
Abstract

ObjectiveThe object of this study was to test the hypothesis that BRAF is a low-risk susceptibility gene for low malignant potential (LMP) ovarian cancer. A recent study of the relationship between BRAF polymorphisms and malignant melanoma identified strong linkage disequilibrium across the BRAF gene with one of the three most common haplotypes (haplotype C) having a population attributable risk of approximately 1.6%. We therefore hypothesized that the same BRAF haplotype may confer an increased risk of serous ovarian tumors of low malignant potential.MethodsWe genotyped 383 cases of LMP ovarian cancer, including 234 of serous histology, and 987 controls for seven SNPs, representative of the most common BRAF gene haplotypes, using MALDI-TOF mass spectrometry.ResultsHaplotype information was obtained for 369 LMP ovarian cancer cases and 983 healthy controls. None of the haplotypes were found to be associated with risk of LMP ovarian cancer (OR for haplotype C 0.81, 95% CI = 0.54-1.22), or with the risk of serous LMP ovarian cancer (OR for haplotype C 0.90, 95% CI = 0.56-1.45).ConclusionWe found no evidence to suggest that BRAF is a low-risk LMP ovarian cancer susceptibility gene.

Published
2005

3. Supplementary Tables 1-2 from Genetic Variation in TYMS in the One-Carbon Transfer Pathway Is Associated with Ovarian Carcinoma Types in the Ovarian Cancer Association Consortium

Author

Kelemen, Linda E., primary, Goodman, Marc T., primary, McGuire, Valerie, primary, Rossing, Mary Anne, primary, Webb, Penelope M., primary, Köbel, Martin, primary, Anton-Culver, Hoda, primary, Beesley, Jonathan, primary, Berchuck, Andrew, primary, Brar, Sony, primary, Carney, Michael E., primary, Chang-Claude, Jenny, primary, Chenevix-Trench, Georgia, primary, Cramer, Daniel W., primary, Cunningham, Julie M., primary, DiCioccio, Richard A., primary, Doherty, Jennifer A., primary, Easton, Douglas F., primary, Fredericksen, Zachary S., primary, Fridley, Brooke L., primary, Gates, Margaret A., primary, Gayther, Simon A., primary, Gentry-Maharaj, Aleksandra, primary, Høgdall, Estrid, primary, Kjær, Susanne Krüger, primary, Lurie, Galina, primary, Menon, Usha, primary, Moorman, Patricia G., primary, Moysich, Kirsten, primary, Ness, Roberta B., primary, Palmieri, Rachel T., primary, Pearce, Celeste L., primary, Pharoah, Paul D.P., primary, Ramus, Susan J., primary, Song, Honglin, primary, Stram, Daniel O., primary, Tworoger, Shelley S., primary, Van Den Berg, David, primary, Vierkant, Robert A., primary, Wang-Gohrke, Shan, primary, Whittemore, Alice S., primary, Wilkens, Lynne R., primary, Wu, Anna H., primary, Schildkraut, Joellen M., primary, Sellers, Thomas A., primary, and Goode, Ellen L., primary

Published
2023
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4. Supplementary Table S1 from Effects of Common Germ-Line Genetic Variation in Cell Cycle Genes on Ovarian Cancer Survival

Author

Song, Honglin, primary, Hogdall, Estrid, primary, Ramus, Susan J., primary, DiCioccio, Richard A., primary, Hogdall, Claus, primary, Quaye, Lydia, primary, McGuire, Valerie, primary, Whittemore, Alice S., primary, Shah, Mitul, primary, Greenberg, David, primary, Easton, Douglas F., primary, Kjaer, Susanne Kruger, primary, Pharoah, Paul D.P., primary, and Gayther, Simon A., primary

Published
2023
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5. Supplementary Table 1 from Association Study of Prostate Cancer Susceptibility Variants with Risks of Invasive Ovarian, Breast, and Colorectal Cancer

Author

Song, Honglin, primary, Koessler, Thibaud, primary, Ahmed, Shahana, primary, Ramus, Susan J., primary, Kjaer, Susanne Krüger, primary, DiCioccio, Richard A., primary, Wozniak, Eva, primary, Hogdall, Estrid, primary, Whittemore, Alice S., primary, McGuire, Valerie, primary, Ponder, Bruce A.J., primary, Turnbull, Clare, primary, Hines, Sarah, primary, Rahman, Nazneen, primary, Eeles, Rosalind A., primary, Easton, Douglas F., primary, Gayther, Simon A., primary, Dunning, Alison M., primary, and Pharoah, Paul D.P., primary

Published
2023
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6. Data from Association Study of Prostate Cancer Susceptibility Variants with Risks of Invasive Ovarian, Breast, and Colorectal Cancer

Author

Song, Honglin, primary, Koessler, Thibaud, primary, Ahmed, Shahana, primary, Ramus, Susan J., primary, Kjaer, Susanne Krüger, primary, DiCioccio, Richard A., primary, Wozniak, Eva, primary, Hogdall, Estrid, primary, Whittemore, Alice S., primary, McGuire, Valerie, primary, Ponder, Bruce A.J., primary, Turnbull, Clare, primary, Hines, Sarah, primary, Rahman, Nazneen, primary, Eeles, Rosalind A., primary, Easton, Douglas F., primary, Gayther, Simon A., primary, Dunning, Alison M., primary, and Pharoah, Paul D.P., primary

Published
2023
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7. Supplementary Tables 1-4 from Tagging Single Nucleotide Polymorphisms in Cell Cycle Control Genes and Susceptibility to Invasive Epithelial Ovarian Cancer

Author

Gayther, Simon A., primary, Song, Honglin, primary, Ramus, Susan J., primary, Kjaer, Susan Krüger, primary, Whittemore, Alice S., primary, Quaye, Lydia, primary, Tyrer, Jonathan, primary, Shadforth, Danielle, primary, Hogdall, Estrid, primary, Hogdall, Claus, primary, Blaeker, Jan, primary, DiCioccio, Richard, primary, McGuire, Valerie, primary, Webb, Penelope M., primary, Beesley, Jonathan, primary, Green, Adele C., primary, Whiteman, David C., primary, Goodman, Marc T., primary, Lurie, Galina, primary, Carney, Michael E., primary, Modugno, Francesmary, primary, Ness, Roberta B., primary, Edwards, Robert P., primary, Moysich, Kirsten B., primary, Goode, Ellen L., primary, Couch, Fergus J., primary, Cunningham, Julie M., primary, Sellers, Thomas A., primary, Wu, Anna H., primary, Pike, Malcolm C., primary, Iversen, Edwin S., primary, Marks, Jeffrey R., primary, Garcia-Closas, Montserrat, primary, Brinton, Louise, primary, Lissowska, Jolanta, primary, Peplonska, Beata, primary, Easton, Douglas F., primary, Jacobs, Ian, primary, Ponder, Bruce A.J., primary, Schildkraut, Joellen, primary, Pearce, C. Leigh, primary, Chenevix-Trench, Georgia, primary, Berchuck, Andrew, primary, and Pharoah, Paul D.P., primary

Published
2023
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8. Vitamin D receptor rs2228570 polymorphism and invasive ovarian carcinoma risk: Pooled analysis in five studies within the Ovarian Cancer Association Consortium

Author

Lurie, Galina, Wilkens, Lynne R., Thompson, Pamela J., Carney, Michael E., Palmieri, Rachel T., Pharoah, Paul D. P., Song, Honglin, Hogdall, Estrid, Kjaer, Susanne Kruger, DiCioccio, Richard A., McGuire, Valerie, Whittemore, Alice S., Gayther, Simon A., Gentry-Maharaj, Aleksandra, Menon, Usha, Ramus, Susan J., and Goodman, Marc T.

Published
2011
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11. Multiple Loci With Different Cancer Specificities Within the 8q24 Gene Desert

Author

Ghoussaini, Maya, Song, Honglin, Koessler, Thibaud, Al Olama, Ali Amin, Kote-Jarai, Zsofia, Driver, Kristy E., Pooley, Karen A., Ramus, Susan J., Kjaer, Susanne Krüger, Hogdall, Estrid, DiCioccio, Richard A., Whittemore, Alice S., Gayther, Simon A., Giles, Graham G., Guy, Michelle, Edwards, Stephen M., Morrison, Jonathan, Donovan, Jenny L., Hamdy, Freddie C., Dearnaley, David P., Ardern-Jones, Audrey T., Hall, Amanda L., OʼBrien, Lynne T., Gehr-Swain, Beatrice N., Wilkinson, Rosemary A., Brown, Paul M., Hopper, John L., Neal, David E., Pharoah, Paul D. P., Ponder, Bruce A. J., Eeles, Rosalind A., Easton, Douglas F., and Dunning, Alison M.

Published
2008

14. Common variants in mismatch repair genes and risk of invasive ovarian cancer

Author

Song, Honglin, Ramus, Susan J., Quaye, Lydia, DiCioccio, Richard A., Tyrer, Jonathan, Lomas, Emma, Shadforth, Danielle, Hogdall, Estrid, Hogdall, Claus, McGuire, Valerie, Whittemore, Alice S., Easton, Douglas F., Ponder, Bruce A.J., Kjaer, Susanne Kruger, Pharoah, Paul D.P., and Gayther, Simon A.

Published
2006

18. Specificity analysis of three clonal and five non-clonal alpha-1,3-L-fucosyltransferases with sulfated, sialylated, or fucosylated synthetic carbohydrates as acceptors in relation to the assembly of 3'-sialyl-6'-sulfo Lewis x (the L-selectin ligand) and related complex structures

Author

Chandrasekaran, E.V., Jain, Rakesh K., Larsen, Robert D., Wlasichuk, Ken, DiCioccio, Richard A., and Matta, Khushi L.

Subjects
Enzyme activation -- Research, Immunospecificity -- Research, Antigenic determinants -- Research, Biological sciences, Chemistry
Abstract

The cloned alpha-1,3-L-fucosyltransferases, FT III, FT IV, and FT V, have unique specificities for blood group type 2-based carbohydrate ligands and antigenic determinants. FT V participates more in the production of Lewis y than Lewis x. FT IV is very effective in synthesizing both 3'-sulfo Lewis x and Lewis x in mucin-type branched chains. Both FT III and FT V are more effective in synthesizing 3'-sulfo Lewis x than 3'-sialyl Lewis x. FT IV is more effective in synthesizing 6-sulfo Lewis x than the other two.

Published
1996

21. Novel genetic variants in miR-191 gene and familial ovarian cancer

Author

Lele Shashikant B, Odunsi Kunle, DiCioccio Richard, Shen Jie, and Zhao Hua

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Half of the familial aggregation of ovarian cancer can't be explained by any known risk genes, suggesting the existence of other genetic risk factors. Some of these unknown factors may not be traditional protein encoding genes. MicroRNA (miRNA) plays a critical role in tumorigenesis, but it is still unknown if variants in miRNA genes lead to predisposition to cancer. Considering the fact that miRNA regulates a number of tumor suppressor genes (TSGs) and oncogenes, genetic variations in miRNA genes could affect the levels of expression of TSGs or oncogenes and, thereby, cancer risk. Methods and Results To test this hypothesis in familial ovarian cancer, we screened for genetic variants in thirty selected miRNA genes, which are predicted to regulate key ovarian cancer genes and are reported to be misexpressed in ovarian tumor tissues, in eighty-three patients with familial ovarian cancer. All of the patients are non-carriers of any known BRCA1/2 or mismatch repair (MMR) gene mutations. Seven novel genetic variants were observed in four primary or precursor miRNA genes. Among them, three rare variants were found in the precursor or primary precursor of the miR-191 gene. In functional assays, the one variant located in the precursor of miR-191 resulted in conformational changes in the predicted secondary structures, and consequently altered the expression of mature miR-191. In further analysis, we found that this particular variant exists in five family members who had ovarian cancer. Conclusions Our findings suggest that there are novel genetic variants in miRNA genes, and those certain genetic variants in miRNA genes can affect the expression of mature miRNAs and, consequently, might alter the regulation of TSGs or oncogenes. Additionally, the variant might be potentially associated with the development of familial ovarian cancer.

Published
2010
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25. Aberrations of TACC1 and TACC3 are associated with ovarian cancer

Author

DiCioccio Richard A, Chervinsky David, Eddy Roger, Vaughan Mary M, Lauffart Brenda, Black Jennifer D, and Still Ivan H

Subjects
Gynecology and obstetrics, RG1-991, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Dysregulation of the human Transforming Acidic Coiled Coil (TACC) genes is thought to be important in the development and progression of multiple myeloma, breast and gastric cancer. Recent, large-scale genomic analysis and Serial Analysis of Gene Expression data suggest that TACC1 and TACC3 may also be involved in the etiology of ovarian tumors from both familial and sporadic cases. Therefore, the aim of this study was to determine the occurrence of alterations of these TACCs in ovarian cancer. Methods Detection and scoring of TACC1 and TACC3 expression was performed by immunohistochemical analysis of the T-BO-1 tissue/tumor microarray slide from the Cooperative Human Tissue Network, Tissue Array Research Program (TARP) of the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Tumors were categorized as either positive (greater than 10% of cells staining) or negative. Statistical analysis was performed using Fisher's exact test and p < 0.05 (single comparisons), and p < 0.02 (multiple comparisons) were considered to be significant. Transgenomics WAVE high performance liquid chromatography (dHPLC) was used to pre-screen the TACC3 gene in constitutional DNA from ovarian cancer patients and their unaffected relatives from 76 families from the Gilda Radner Familial Ovarian Cancer Registry. All variant patterns were then sequenced. Results This study demonstrated absence of at least one or both TACC proteins in 78.5% (51/65) of ovarian tumors tested, with TACC3 loss observed in 67.7% of tumors. The distribution pattern of expression of the two TACC proteins was different, with TACC3 loss being more common in serous papillary carcinoma compared with clear cell carcinomas, while TACC1 staining was less frequent in endometroid than in serous papillary tumor cores. In addition, we identified two constitutional mutations in the TACC3 gene in patients with ovarian cancer from the Gilda Radner Familial Ovarian Cancer Registry. These patients had previously tested negative for mutations in known ovarian cancer predisposing genes. Conclusion When combined, our data suggest that aberrations of TACC genes, and TACC3 in particular, underlie a significant proportion of ovarian cancers. Thus, TACC3 could be a hitherto unknown endogenous factor that contributes to ovarian tumorigenesis.

Published
2005
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32. Genetic Variation in TYMS in the One-Carbon Transfer Pathway Is Associated with Ovarian Carcinoma Types in the Ovarian Cancer Association Consortium

Author

Stram, Daniel O., Chenevix-Trench, Georgia, Anton-Culver, Hoda, Menon, Usha, Kjær, Susanne Krüger, McGuire, Valerie, Chang-Claude, Jenny, Webb, Penelope M., Kelemen, Linda E., Fredericksen, Zachary S., Wu, Anna H., Tworoger, Shelley S., Ramus, Susan J., Van Den Berg, David, Lurie, Galina, Beesley, Jonathan, Gates, Margaret A., Pharoah, Paul D.P., Schildkraut, Joellen M., Pearce, Celeste L., Høgdall, Estrid, Goodman, Marc T., Moysich, Kirsten, Doherty, Jennifer A., DiCioccio, Richard A., Vierkant, Robert A., Carney, Michael E., Brar, Sony, Gentry-Maharaj, Aleksandra, Cramer, Daniel W., Berchuck, Andrew, Whittemore, Alice S., Easton, Douglas F., Rossing, Mary Anne, Moorman, Patricia G., Gayther, Simon A., Köbel, Martin, Song, Honglin, Goode, Ellen L., Palmieri, Rachel T., Wilkens, Lynne R., Ness, Roberta B., Fridley, Brooke L., Wang-Gohrke, Shan, Cunningham, Julie M., and Sellers, Thomas A.

Abstract

We previously reported risks of ovarian carcinoma for common polymorphisms in one-carbon (1-C) transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS rs17284990 and TYMS rs495139 with risk of ovarian carcinoma overall, and to utilize the large sample of assembled cases to investigate associations by histological type.

Published
2010
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33. Candidate Gene Analysis Using Imputed Genotypes: Cell Cycle SNPs and Ovarian Cancer Risk

Author

Goode, Ellen L., Fridley, Brooke L., Vierkant, Robert A., Cunningham, Julie M., Phelan, Catherine M., Anderson, Stephanie, Rider, David N., White, Kristin L., Pankratz, V. Shane, Song, Honglin, Hogdall, Estrid, Kjaer, Susanne K., Whittemore, Alice S., DiCioccio, Richard, Ramus, Susan J., Gayther, Simon A., Schildkraut, Joellen M., Pharaoh, Paul P.D., and Sellers, Thomas A.

Subjects
Adult, Oncogene Proteins, Ovarian Neoplasms, Risk, Genotype, Minnesota, Cell Cycle, Cyclin-Dependent Kinase 2, Middle Aged, Polymorphism, Single Nucleotide, Article, Markov Chains, Logistic Models, Case-Control Studies, Cyclin E, North Carolina, Humans, Cyclin D1, Female, Neoplasm Invasiveness, Registries, Alleles, Cyclin-Dependent Kinase Inhibitor p16, Aged, Cyclin-Dependent Kinase Inhibitor p15
Abstract

Polymorphisms in genes critical to cell cycle control are outstanding candidates for association with ovarian cancer risk; numerous genes have been interrogated by multiple research groups using differing tagging single-nucleotide polymorphism (SNP) sets. To maximize information gleaned from existing genotype data, we conducted a combined analysis of five independent studies of invasive epithelial ovarian cancer. Up to 2,120 cases and 3,382 controls were genotyped in the course of two collaborations at a variety of SNPs in 11 cell cycle genes (CDKN2C, CDKN1A, CCND3, CCND1, CCND2, CDKN1B, CDK2, CDK4, RB1, CDKN2D, and CCNE1) and one gene region (CDKN2A-CDKN2B). Because of the semi-overlapping nature of the 123 assayed tagging SNPs, we performed multiple imputation based on fastPHASE using data from White non-Hispanic study participants and participants in the international HapMap Consortium and National Institute of Environmental Health Sciences SNPs Program. Logistic regression assuming a log-additive model was done on combined and imputed data. We observed strengthened signals in imputation-based analyses at several SNPs, particularly CDKN2A-CDKN2B rs3731239; CCND1 rs602652, rs3212879, rs649392, and rs3212891; CDK2 rs2069391, rs2069414, and rs17528736; and CCNE1 rs3218036. These results exemplify the utility of imputation in candidate gene studies and lend evidence to a role of cell cycle genes in ovarian cancer etiology, suggest a reduced set of SNPs to target in additional cases and controls.

Published
2009

34. Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study

Author

Chenevix-Trench, Georgia, Webb, Penny M., Thompson, Pamela J., Ness, Roberta B., Hogdall, Estrid, Chen, Xiaoqing, Van Den Berg, David J., McGuire, Valerie, DiCioccio, Richard A., Whittemore, Alice S., Gentry-Maharaj, Aleksandra, Wu, Anna H., Song, Honglin, Pearce, Celeste Leigh, Beesley, Jonathan, Kjaer, Susanne Krüger, Goodman, Marc T., Rossing, Mary Anne, Doherty, Jennifer A., Ramus, Susan J., Jacobs, Ian J., Hogdall, Claus, Moysich, Kirsten, Blaakaer, Jan, Menon, Usha, Carney, Michael E., Chang-Claude, Jenny, Goode, Ellen L., Wang-Gohrke, Shan, Lurie, Galina, Stram, Daniel O., and Vierkant, Robert A.

Subjects
endocrine system diseases, female genital diseases and pregnancy complications
Abstract

Because both ovarian and breast cancer are hormone-related and are known to have some predisposition genes in common, we evaluated 11 of the most significant hits (six with confirmed associations with breast cancer) from the breast cancer genome-wide association study for association with invasive ovarian cancer. Eleven SNPs were initially genotyped in 2927 invasive ovarian cancer cases and 4143 controls from six ovarian cancer case–control studies. Genotype frequencies in cases and controls were compared using a likelihood ratio test in a logistic regression model stratified by study. Initially, three SNPs (rs2107425 in MRPL23, rs7313833 in PTHLH, rs3803662 in TNRC9) were weakly associated with ovarian cancer risk and one SNP (rs4954956 in NXPH2) was associated with serous ovarian cancer in non-Hispanic white subjects (P-trend < 0.1). These four SNPs were then genotyped in an additional 4060 cases and 6308 controls from eight independent studies. Only rs4954956 was significantly associated with ovarian cancer risk both in the replication study and in combined analyses. This association was stronger for the serous histological subtype [per minor allele odds ratio (OR) 1.07 95% CI 1.01–1.13, P-trend = 0.02 for all types of ovarian cancer and OR 1.14 95% CI 1.07–1.22, P-trend = 0.00017 for serous ovarian cancer]. In conclusion, we found that rs4954956 was associated with increased ovarian cancer risk, particularly for serous ovarian cancer. However, none of the six confirmed breast cancer susceptibility variants we tested was associated with ovarian cancer risk. Further work will be needed to identify the causal variant associated with rs4954956 or elucidate its function.

Published
2009
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35. A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2

Author

Chen, Zhihua, Schildkraut, Joellen M, Goode, Ellen L, Dürst, Matthias, Giles, Graham, Fenstermacher, David, Chang-Claude, Jenny, Doherty, Jennifer A, Beckmann, Matthias W, Carney, Michael E, Goodman, Marc T, Baglietto, Laura, Fridley, Brooke L, Anton-Culver, Hoda, De Vivo, Immaculata, Gore, Martin E, Dörk, Thilo, Ramus, Susan J, Song, Honglin, Chanock, Stephen, Cunningham, Julie M, Gentry-Maharaj, Aleksandra, Cramer, Daniel W, DiCioccio, Richard, Dicks, Ed, Blaakaer, Jan, Bolton, Kelly L, Ekici, Arif B, Beesley, Jonathan, Sellers, Thomas, Tyrer, Jonathan, and Wozniak, Eva

Abstract

Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk1. We performed a genome wide association study (GWAS) to identify common ovarian cancer susceptibility alleles. We evaluated 507,094 SNPs genotyped in 1,817 cases and 2,353 controls from the UK and ~2 million imputed SNPs. We genotyped the 22,790 top ranked SNPs in 4,274 cases and 4,809 controls of European ancestry from Europe, USA and Australia. We identified 12 SNPs at 9p22 associated with disease risk (P

Published
2009
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36. Consortium analysis of 7 candidate SNPs for ovarian cancer

Author

Ramus, Susan J, Vierkant, Robert A, Johnatty, Sharon E, Pike, Malcolm C, Van Den Berg, David J, Wu, Anna H, Pearce, Celeste Leigh, Menon, Usha, Gentry-Maharaj, Aleksandra, Gayther, Simon A, Dicioccio, Richard A, McGuire, Valerie, Whittemore, Alice S, Song, Honglin, Easton, Douglas F, Pharoah, Paul D P, Garcia-Closas, Montserrat, Chanock, Stephen, Lissowska, Jolanta, Brinton, Louise, Terry, Kathryn L, Cramer, Daniel W, Tworoger, Shelley S, Hankinson, Susan E, Berchuck, Andrew, Moorman, Patricia G, Schildkraut, Joellen M, Cunningham, Julie M, Liebow, Mark, Kjaer, Susanne Krüger, Hogdall, Estrid, Hogdall, Claus, Blaakaer, Jan, Ness, Roberta B, Moysich, Kirsten B, Edwards, Robert P, Carney, Michael E, Lurie, Galina, Goodman, Marc T, Wang-Gohrke, Shan, Kropp, Silke, Chang-Claude, Jenny, Webb, Penelope M, Chen, Xiaoqing, Beesley, Jonathan, Chenevix-Trench, Georgia, and Goode, Ellen L

Subjects
Genotype, European Continental Ancestry Group, Breast Neoplasms, Protein Serine-Threonine Kinases, Testosterone 5-alpha-Reductase, Polymorphism, Single Nucleotide, Retinoblastoma Protein, Article, White People, Transforming Growth Factor beta1, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, Aurora Kinases, Odds Ratio, Humans, Cyclin-Dependent Kinase Inhibitor p16, Aurora Kinase A, BRCA2 Protein, Ovarian Neoplasms, Caspase 8, Carcinoma, Protein-Serine-Threonine Kinases, Neoplasm Proteins, Case-Control Studies, Mutation, Female, Apoptosis Regulatory Proteins
Abstract

Udgivelsesdato: 2008-Jul-15 The Ovarian Cancer Association Consortium selected 7 candidate single nucleotide polymorphisms (SNPs), for which there is evidence from previous studies of an association with variation in ovarian cancer or breast cancer risks. The SNPs selected for analysis were F31I (rs2273535) in AURKA, N372H (rs144848) in BRCA2, rs2854344 in intron 17 of RB1, rs2811712 5' flanking CDKN2A, rs523349 in the 3' UTR of SRD5A2, D302H (rs1045485) in CASP8 and L10P (rs1982073) in TGFB1. Fourteen studies genotyped 4,624 invasive epithelial ovarian cancer cases and 8,113 controls of white non-Hispanic origin. A marginally significant association was found for RB1 when all studies were included [ordinal odds ratio (OR) 0.88 (95% confidence interval (CI) 0.79-1.00) p = 0.041 and dominant OR 0.87 (95% CI 0.76-0.98) p = 0.025]; when the studies that originally suggested an association were excluded, the result was suggestive although no longer statistically significant (ordinal OR 0.92, 95% CI 0.79-1.06). This SNP has also been shown to have an association with decreased risk in breast cancer. There was a suggestion of an association for AURKA, when one study that caused significant study heterogeneity was excluded [ordinal OR 1.10 (95% CI 1.01-1.20) p = 0.027; dominant OR 1.12 (95% CI 1.01-1.24) p = 0.03]. The other 5 SNPs in BRCA2, CDKN2A, SRD5A2, CASP8 and TGFB1 showed no association with ovarian cancer risk; given the large sample size, these results can also be considered to be informative. These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach.

Published
2008
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37. Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium

Author

Kelemen, Linda E, Goodman, Marc T, McGuire, Valerie, Rossing, Mary Anne, Webb, Penelope M, Köbel, Martin, Anton-Culver, Hoda, Beesley, Jonathan, Berchuck, Andrew, Brar, Sony, Carney, Michael E, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Cramer, Daniel W, Cunningham, Julie M, Dicioccio, Richard A, Doherty, Jennifer A, Easton, Douglas F, Fredericksen, Zachary S, Fridley, Brooke L, Gates, Margaret A, Gayther, Simon A, Gentry-Maharaj, Aleksandra, Høgdall, Estrid, Kjaer, Susanne Krüger, Lurie, Galina, Menon, Usha, Moorman, Patricia G, Moysich, Kirsten, Ness, Roberta B, Palmieri, Rachel T, Pearce, Celeste L, Pharoah, Paul D P, Ramus, Susan J, Song, Honglin, Stram, Daniel O, Tworoger, Shelley S, Van Den Berg, David, Vierkant, Robert A, Wang-Gohrke, Shan, Whittemore, Alice S, Wilkens, Lynne R, Wu, Anna H, Schildkraut, Joellen M, Sellers, Thomas A, Goode, Ellen L, Kelemen, Linda E, Goodman, Marc T, McGuire, Valerie, Rossing, Mary Anne, Webb, Penelope M, Köbel, Martin, Anton-Culver, Hoda, Beesley, Jonathan, Berchuck, Andrew, Brar, Sony, Carney, Michael E, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Cramer, Daniel W, Cunningham, Julie M, Dicioccio, Richard A, Doherty, Jennifer A, Easton, Douglas F, Fredericksen, Zachary S, Fridley, Brooke L, Gates, Margaret A, Gayther, Simon A, Gentry-Maharaj, Aleksandra, Høgdall, Estrid, Kjaer, Susanne Krüger, Lurie, Galina, Menon, Usha, Moorman, Patricia G, Moysich, Kirsten, Ness, Roberta B, Palmieri, Rachel T, Pearce, Celeste L, Pharoah, Paul D P, Ramus, Susan J, Song, Honglin, Stram, Daniel O, Tworoger, Shelley S, Van Den Berg, David, Vierkant, Robert A, Wang-Gohrke, Shan, Whittemore, Alice S, Wilkens, Lynne R, Wu, Anna H, Schildkraut, Joellen M, Sellers, Thomas A, and Goode, Ellen L

Abstract

We previously reported the risks of ovarian carcinoma for common polymorphisms in one-carbon transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS rs17284990, and TYMS rs495139 with risk of ovarian carcinoma overall and to use the large sample of assembled cases to investigate associations by histologic type.

Published
2010

38. Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium

Author

Phelan, Catherine M, Tsai, Ya-Yu, Goode, Ellen L, Vierkant, Robert A, Fridley, Brooke L, Beesley, Jonathan, Chen, Xiao Qing, Webb, Penelope M, Chanock, Stephen, Cramer, Daniel W, Moysich, Kirsten, Edwards, Robert P, Chang-Claude, Jenny, Garcia-Closas, Montserrat, Yang, Hannah, Wang-Gohrke, Shan, Hein, Rebecca, Green, Adele C, Lissowska, Jolanta, Carney, Michael E, Lurie, Galina, Wilkens, Lynne R, Ness, Roberta B, Pearce, Celeste Leigh, Wu, Anna H, Van Den Berg, David J, Stram, Daniel O, Terry, Kathryn L, Whiteman, David C, Whittemore, Alice S, DiCioccio, Richard A, McGuire, Valerie, Doherty, Jennifer A, Rossing, Mary Anne, Anton-Culver, Hoda, Ziogas, Argyrios, Hogdall, Claus, Hogdall, Estrid, Krüger Kjaer, Susanne, Blaakaer, Jan, Quaye, Lydia, Ramus, Susan J, Jacobs, Ian, Song, Honglin, Pharoah, Paul D P, Iversen, Edwin S, Marks, Jeffrey R, Pike, Malcolm C, Gayther, Simon A, Cunningham, Julie M, Phelan, Catherine M, Tsai, Ya-Yu, Goode, Ellen L, Vierkant, Robert A, Fridley, Brooke L, Beesley, Jonathan, Chen, Xiao Qing, Webb, Penelope M, Chanock, Stephen, Cramer, Daniel W, Moysich, Kirsten, Edwards, Robert P, Chang-Claude, Jenny, Garcia-Closas, Montserrat, Yang, Hannah, Wang-Gohrke, Shan, Hein, Rebecca, Green, Adele C, Lissowska, Jolanta, Carney, Michael E, Lurie, Galina, Wilkens, Lynne R, Ness, Roberta B, Pearce, Celeste Leigh, Wu, Anna H, Van Den Berg, David J, Stram, Daniel O, Terry, Kathryn L, Whiteman, David C, Whittemore, Alice S, DiCioccio, Richard A, McGuire, Valerie, Doherty, Jennifer A, Rossing, Mary Anne, Anton-Culver, Hoda, Ziogas, Argyrios, Hogdall, Claus, Hogdall, Estrid, Krüger Kjaer, Susanne, Blaakaer, Jan, Quaye, Lydia, Ramus, Susan J, Jacobs, Ian, Song, Honglin, Pharoah, Paul D P, Iversen, Edwin S, Marks, Jeffrey R, Pike, Malcolm C, Gayther, Simon A, and Cunningham, Julie M

Abstract

Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for heterogeneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.

Published
2010

39. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk

Author

Goode, Ellen L, Fridley, Brooke L, Vierkant, Robert A, Cunningham, Julie M, Phelan, Catherine M, Anderson, Stephanie, Rider, David N, White, Kristin L, Pankratz, V Shane, Song, Honglin, Hogdall, Estrid, Kjaer, Susanne K, Whittemore, Alice S, DiCioccio, Richard, Ramus, Susan J, Gayther, Simon A, Schildkraut, Joellen M, Pharaoh, Paul P D, Sellers, Thomas A, Goode, Ellen L, Fridley, Brooke L, Vierkant, Robert A, Cunningham, Julie M, Phelan, Catherine M, Anderson, Stephanie, Rider, David N, White, Kristin L, Pankratz, V Shane, Song, Honglin, Hogdall, Estrid, Kjaer, Susanne K, Whittemore, Alice S, DiCioccio, Richard, Ramus, Susan J, Gayther, Simon A, Schildkraut, Joellen M, Pharaoh, Paul P D, and Sellers, Thomas A

Abstract

Udgivelsesdato: 2009-Mar, Polymorphisms in genes critical to cell cycle control are outstanding candidates for association with ovarian cancer risk; numerous genes have been interrogated by multiple research groups using differing tagging single-nucleotide polymorphism (SNP) sets. To maximize information gleaned from existing genotype data, we conducted a combined analysis of five independent studies of invasive epithelial ovarian cancer. Up to 2,120 cases and 3,382 controls were genotyped in the course of two collaborations at a variety of SNPs in 11 cell cycle genes (CDKN2C, CDKN1A, CCND3, CCND1, CCND2, CDKN1B, CDK2, CDK4, RB1, CDKN2D, and CCNE1) and one gene region (CDKN2A-CDKN2B). Because of the semi-overlapping nature of the 123 assayed tagging SNPs, we performed multiple imputation based on fastPHASE using data from White non-Hispanic study participants and participants in the international HapMap Consortium and National Institute of Environmental Health Sciences SNPs Program. Logistic regression assuming a log-additive model was done on combined and imputed data. We observed strengthened signals in imputation-based analyses at several SNPs, particularly CDKN2A-CDKN2B rs3731239; CCND1 rs602652, rs3212879, rs649392, and rs3212891; CDK2 rs2069391, rs2069414, and rs17528736; and CCNE1 rs3218036. These results exemplify the utility of imputation in candidate gene studies and lend evidence to a role of cell cycle genes in ovarian cancer etiology, suggest a reduced set of SNPs to target in additional cases and controls.

Published
2009

40. Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer

Author

Quaye, Lydia, Tyrer, Jonathan, Ramus, Susan J, Song, Honglin, Wozniak, Eva, DiCioccio, Richard A, McGuire, Valerie, Høgdall, Estrid, Høgdall, Claus, Blaakaer, Jan, Goode, Ellen L, Schildkraut, Joellen M, Easton, Douglas F, Krüger-Kjaer, Susanne, Whittemore, Alice S, Gayther, Simon A, Pharoah, Paul D P, Quaye, Lydia, Tyrer, Jonathan, Ramus, Susan J, Song, Honglin, Wozniak, Eva, DiCioccio, Richard A, McGuire, Valerie, Høgdall, Estrid, Høgdall, Claus, Blaakaer, Jan, Goode, Ellen L, Schildkraut, Joellen M, Easton, Douglas F, Krüger-Kjaer, Susanne, Whittemore, Alice S, Gayther, Simon A, and Pharoah, Paul D P

Abstract

Udgivelsesdato: 2009-null, BACKGROUND: Recent studies have identified several single nucleotide polymorphisms (SNPs) in the population that are associated with variations in the risks of many different diseases including cancers such as breast, prostate and colorectal. For ovarian cancer, the known highly penetrant susceptibility genes (BRCA1 and BRCA2) are probably responsible for only 40% of the excess familial ovarian cancer risks, suggesting that other susceptibility genes of lower penetrance exist. METHODS: We have taken a candidate approach to identifying moderate risk susceptibility alleles for ovarian cancer. To date, we have genotyped 340 SNPs from 94 candidate genes or regions, in up to 1,491 invasive epithelial ovarian cancer cases and 3,145 unaffected controls from three different population based studies from the UK, Denmark and USA. RESULTS: After adjusting for population stratification by genomic control, 18 SNPs (5.3%) were significant at the 5% level, and 5 SNPs (1.5%) were significant at the 1% level. The most significant association was for the SNP rs2107425, located on chromosome 11p15.5, which has previously been identified as a susceptibility allele for breast cancer from a genome wide association study (P-trend = 0.0012). When SNPs/genes were stratified into 7 different pathways or groups of validation SNPs, the breast cancer associated SNPs were the only group of SNPs that were significantly associated with ovarian cancer risk (P-heterogeneity = 0.0003; P-trend = 0.0028; adjusted (for population stratification) P-trend = 0.006). We did not find statistically significant associations when the combined data for all SNPs were analysed using an admixture maximum likelihood (AML) experiment-wise test for association (P-heterogeneity = 0.051; P-trend = 0.068). CONCLUSION: These data suggest that a proportion of the SNPs we evaluated were associated with ovarian cancer risk, but that the effect sizes were too small to detect associations with individual SNPs.

Published
2009

41. A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2

Author

Song, Honglin, Ramus, Susan J, Tyrer, Jonathan, Bolton, Kelly L, Gentry-Maharaj, Aleksandra, Wozniak, Eva, Anton-Culver, Hoda, Chang-Claude, Jenny, Cramer, Daniel W, DiCioccio, Richard, Dörk, Thilo, Goode, Ellen L, Goodman, Marc T, Schildkraut, Joellen M, Sellers, Thomas, Baglietto, Laura, Beckmann, Matthias W, Beesley, Jonathan, Blaakaer, Jan, Carney, Michael E, Chanock, Stephen, Chen, Zhihua, Cunningham, Julie M, Dicks, Ed, Doherty, Jennifer A, Dürst, Matthias, Ekici, Arif B, Fenstermacher, David, Fridley, Brooke L, Giles, Graham, Gore, Martin E, De Vivo, Immaculata, Hillemanns, Peter, Hogdall, Claus, Hogdall, Estrid, Iversen, Edwin S, Jacobs, Ian J, Jakubowska, Anna, Li, Dong, Lissowska, Jolanta, Lubinski, Jan, Lurie, Galina, McGuire, Valerie, McLaughlin, John, Medrek, Krzysztof, Moorman, Patricia G, Moysich, Kirsten, Narod, Steven, Phelan, Catherine, Kjaer, Susanne Krüger, Song, Honglin, Ramus, Susan J, Tyrer, Jonathan, Bolton, Kelly L, Gentry-Maharaj, Aleksandra, Wozniak, Eva, Anton-Culver, Hoda, Chang-Claude, Jenny, Cramer, Daniel W, DiCioccio, Richard, Dörk, Thilo, Goode, Ellen L, Goodman, Marc T, Schildkraut, Joellen M, Sellers, Thomas, Baglietto, Laura, Beckmann, Matthias W, Beesley, Jonathan, Blaakaer, Jan, Carney, Michael E, Chanock, Stephen, Chen, Zhihua, Cunningham, Julie M, Dicks, Ed, Doherty, Jennifer A, Dürst, Matthias, Ekici, Arif B, Fenstermacher, David, Fridley, Brooke L, Giles, Graham, Gore, Martin E, De Vivo, Immaculata, Hillemanns, Peter, Hogdall, Claus, Hogdall, Estrid, Iversen, Edwin S, Jacobs, Ian J, Jakubowska, Anna, Li, Dong, Lissowska, Jolanta, Lubinski, Jan, Lurie, Galina, McGuire, Valerie, McLaughlin, John, Medrek, Krzysztof, Moorman, Patricia G, Moysich, Kirsten, Narod, Steven, Phelan, Catherine, and Kjaer, Susanne Krüger

Abstract

Udgivelsesdato: 2009-Sep, Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk. We performed a genome-wide association study (GWAS) to identify common ovarian cancer susceptibility alleles. We evaluated 507,094 SNPs genotyped in 1,817 cases and 2,353 controls from the UK and approximately 2 million imputed SNPs. We genotyped the 22,790 top ranked SNPs in 4,274 cases and 4,809 controls of European ancestry from Europe, USA and Australia. We identified 12 SNPs at 9p22 associated with disease risk (P < 10(-8)). The most significant SNP (rs3814113; P = 2.5 x 10(-17)) was genotyped in a further 2,670 ovarian cancer cases and 4,668 controls, confirming its association (combined data odds ratio (OR) = 0.82, 95% confidence interval (CI) 0.79-0.86, P(trend) = 5.1 x 10(-19)). The association differs by histological subtype, being strongest for serous ovarian cancers (OR 0.77, 95% CI 0.73-0.81, P(trend) = 4.1 x 10(-21)).

Published
2009

42. Familial Site-specific Ovarian Cancer Is Linked to BRCA1 on 17q12-21

Author

Steichen-Gersdorf, Elisabeth, Gallion, Holly H., Ford, Deborah, Girodet, Catherine, Easton, Douglas F., DiCioccio, Richard A., Evans, Gareth, Ponder, Margaret A., Pye, Carole, Mazoyer, Sylvie, Noguchi, Tetsuro, Karengueven, Fabienne, Sobol, Hagay, Hardouin, A., Bignon, Yves-Jean, Piver, M. Steven, Smith, Simon A., and Ponder, Bruce A. J.

Subjects
Ovarian Neoplasms, Polymorphism, Genetic, endocrine system diseases, BRCA1 Protein, Genetic Linkage, Original Articles, Polymerase Chain Reaction, Neoplasm Proteins, Pedigree, Haplotypes, Humans, Female, Lod Score, skin and connective tissue diseases, Chromosomes, Human, Pair 17, Transcription Factors, Research Article
Abstract

In a study of nine families with “site-specific” ovarian cancer (criterion: three or more cases of epithelial ovarian cancer and no cases of breast cancer diagnosed at age

Published
1994

43. Genetic Variation in TYMS in the One-Carbon Transfer Pathway Is Associated with Ovarian Carcinoma Types in the Ovarian Cancer Association Consortium

Author

Kelemen, Linda E., primary, Goodman, Marc T., additional, McGuire, Valerie, additional, Rossing, Mary Anne, additional, Webb, Penelope M., additional, Köbel, Martin, additional, Anton-Culver, Hoda, additional, Beesley, Jonathan, additional, Berchuck, Andrew, additional, Brar, Sony, additional, Carney, Michael E., additional, Chang-Claude, Jenny, additional, Chenevix-Trench, Georgia, additional, Cramer, Daniel W., additional, Cunningham, Julie M., additional, DiCioccio, Richard A., additional, Doherty, Jennifer A., additional, Easton, Douglas F., additional, Fredericksen, Zachary S., additional, Fridley, Brooke L., additional, Gates, Margaret A., additional, Gayther, Simon A., additional, Gentry-Maharaj, Aleksandra, additional, Høgdall, Estrid, additional, Kjær, Susanne Krüger, additional, Lurie, Galina, additional, Menon, Usha, additional, Moorman, Patricia G., additional, Moysich, Kirsten, additional, Ness, Roberta B., additional, Palmieri, Rachel T., additional, Pearce, Celeste L., additional, Pharoah, Paul D.P., additional, Ramus, Susan J., additional, Song, Honglin, additional, Stram, Daniel O., additional, Tworoger, Shelley S., additional, Van Den Berg, David, additional, Vierkant, Robert A., additional, Wang-Gohrke, Shan, additional, Whittemore, Alice S., additional, Wilkens, Lynne R., additional, Wu, Anna H., additional, Schildkraut, Joellen M., additional, Sellers, Thomas A., additional, and Goode, Ellen L., additional

Published
2010
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45. Association between Common Germline Genetic Variation in 94 Candidate Genes or Regions and Risks of Invasive Epithelial Ovarian Cancer

Author

Quaye, Lydia, primary, Tyrer, Jonathan, additional, Ramus, Susan J., additional, Song, Honglin, additional, Wozniak, Eva, additional, DiCioccio, Richard A., additional, McGuire, Valerie, additional, Høgdall, Estrid, additional, Høgdall, Claus, additional, Blaakaer, Jan, additional, Goode, Ellen L., additional, Schildkraut, Joellen M., additional, Easton, Douglas F., additional, Krüger-Kjaer, Susanne, additional, Whittemore, Alice S., additional, Gayther, Simon A., additional, and Pharoah, Paul D. P., additional

Published
2009
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47. Candidate Gene Analysis Using Imputed Genotypes: Cell Cycle Single-Nucleotide Polymorphisms and Ovarian Cancer Risk

Author

Goode, Ellen L., primary, Fridley, Brooke L., additional, Vierkant, Robert A., additional, Cunningham, Julie M., additional, Phelan, Catherine M., additional, Anderson, Stephanie, additional, Rider, David N., additional, White, Kristin L., additional, Pankratz, V. Shane, additional, Song, Honglin, additional, Hogdall, Estrid, additional, Kjaer, Susanne K., additional, Whittemore, Alice S., additional, DiCioccio, Richard, additional, Ramus, Susan J., additional, Gayther, Simon A., additional, Schildkraut, Joellen M., additional, Pharaoh, Paul P.D., additional, and Sellers, Thomas A., additional

Published
2009
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48. Association Study of Prostate Cancer Susceptibility Variants with Risks of Invasive Ovarian, Breast, and Colorectal Cancer

Author

Song, Honglin, primary, Koessler, Thibaud, additional, Ahmed, Shahana, additional, Ramus, Susan J., additional, Kjaer, Susanne Krüger, additional, DiCioccio, Richard A., additional, Wozniak, Eva, additional, Hogdall, Estrid, additional, Whittemore, Alice S., additional, McGuire, Valerie, additional, Ponder, Bruce A.J., additional, Turnbull, Clare, additional, Hines, Sarah, additional, Rahman, Nazneen, additional, Eeles, Rosalind A., additional, Easton, Douglas F., additional, Gayther, Simon A., additional, Dunning, Alison M., additional, and Pharoah, Paul D.P., additional

Published
2008
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49. Mismatch repair gene polymorphisms and survival in invasive ovarian cancer patients

Author

Mann, Andrea, primary, Hogdall, Estrid, additional, Ramus, Susan J., additional, DiCioccio, Richard A., additional, Hogdall, Claus, additional, Quaye, Lydia, additional, McGuire, Valerie, additional, Whittemore, Alice S., additional, Shah, Mitul, additional, Greenberg, David, additional, Easton, Douglas F., additional, Ponder, Bruce A.J., additional, Kjaer, Susanne Krüger, additional, Gayther, Simon A., additional, Thompson, Deborah J., additional, Pharoah, Paul D.P., additional, and Song, Honglin, additional

Published
2008
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50. Consortium analysis of 7 candidate SNPs for ovarian cancer

Author

Ramus, Susan J., primary, Vierkant, Robert A., additional, Johnatty, Sharon E., additional, Pike, Malcolm C., additional, Van Den Berg, David J., additional, Wu, Anna H., additional, Pearce, Celeste Leigh, additional, Menon, Usha, additional, Gentry‐Maharaj, Aleksandra, additional, Gayther, Simon A., additional, DiCioccio, Richard A., additional, McGuire, Valerie, additional, Whittemore, Alice S., additional, Song, Honglin, additional, Easton, Douglas F., additional, Pharoah, Paul D.P., additional, Garcia‐Closas, Montserrat, additional, Chanock, Stephen, additional, Lissowska, Jolanta, additional, Brinton, Louise, additional, Terry, Kathryn L., additional, Cramer, Daniel W., additional, Tworoger, Shelley S., additional, Hankinson, Susan E., additional, Berchuck, Andrew, additional, Moorman, Patricia G., additional, Schildkraut, Joellen M., additional, Cunningham, Julie M., additional, Liebow, Mark, additional, Kjaer, Susanne Krüger, additional, Hogdall, Estrid, additional, Hogdall, Claus, additional, Blaakaer, Jan, additional, Ness, Roberta B., additional, Moysich, Kirsten B., additional, Edwards, Robert P., additional, Carney, Michael E., additional, Lurie, Galina, additional, Goodman, Marc T., additional, Wang‐Gohrke, Shan, additional, Kropp, Silke, additional, Chang‐Claude, Jenny, additional, Webb, Penelope M., additional, Chen, Xiaoqing, additional, Beesley, Jonathan, additional, Chenevix‐Trench, Georgia, additional, and Goode, Ellen L., additional

Published
2008
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