598 results on '"DiAntonio, Aaron"'
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2. The structure of NAD+ consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations
3. Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy
4. Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules
5. Products of gut microbial Toll/interleukin-1 receptor domain NADase activities in gnotobiotic mice and Bangladeshi children with malnutrition
6. FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury
7. Protein phosphatase 2A restrains DLK signaling to promote proper Drosophila synaptic development and mammalian cortical neuron survival
8. Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients
9. Multiple domain interfaces mediate SARM1 autoinhibition
10. Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection
11. Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss
12. SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration
13. SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration
14. Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate
15. The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease
16. cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons
17. TIR domains of plant immune receptors are NAD⁺-cleaving enzymes that promote cell death
18. A SARM1-mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model
19. Macrophage depletion blocks congenital SARMI-dependent neuropathy
20. Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome
21. DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury
22. Synergistic Protection of Retinal Ganglion Cells (RGCs) by SARM1 Inactivation with CNTF in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy
23. Sarm1 knockout prevents type 1 diabetic bone disease in females independent of neuropathy
24. HSP90 is a chaperone for DLK and is required for axon injury signaling
25. Palmitoylation enables MAPK-dependent proteostasis of axon survival factors
26. DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration
27. The Cytoskeletal Stress Response Pathway: a homeostatic system driven by Dual Leucine Zipper Kinase (DLK)
28. Genomewide Analysis of the Drosophila Tetraspanins Reveals a Subset with Similar Function in the Formation of the Embryonic Synapse
29. Domain-centric database to uncover structure of minimally characterized viral genomes
30. Models of Axon Degeneration in Drosophila Larvae
31. The response of Dual-leucine zipper kinase (DLK) to nocodazole: Evidence for a homeostatic cytoskeletal repair mechanism.
32. Models of axon regeneration in Drosophila
33. SARM1-specific motifs in the TIR domain enable NAD⁺ loss and regulate injury-induced SARM1 activation
34. Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism
35. The E3 ligase Highwire promotes synaptic transmission by targeting the NAD‐synthesizing enzyme dNmnat
36. The structure of NAD+ consuming proteinAcinetobacter baumanniiTIR domain shows unique kinetics and conformations.
37. Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury
38. SARM1 activation triggers axon degeneration locally via NAD + destruction
39. SIK3 and Wnk converge on Fray to regulate glial K+ buffering and seizure susceptibility
40. Dynamic regulation of SCG10 in regenerating axons after injury
41. Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling
42. Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death
43. SCG10 is a JNK target in the axonal degeneration pathway
44. Drosophila Golgi membrane protein Ema promotes autophagosomal growth and function
45. The E3 Ubiquitin Ligase Protein Associated with Myc (Pam) Regulates Mammalian/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling in Vivo through N- and C-terminal Domains
46. A large-scale RNAi screen identifies functional classes of genes shaping synaptic development and maintenance
47. Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes
48. Disruption of lactate metabolism in the peripheral nervous system leads to motor-selective deficits
49. Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity
50. Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury
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