31 results on '"Di Zi"'
Search Results
2. Determination of critical damage value of Ti600 alloy based on Normalized Cockcroft & Latham ductile fracture criterion
- Author
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ZHANG Jing-li, WU Jin-ping, LUO Yuan-yuan, ZHAO Bin, GUO Di-zi, ZHAO Sheng-ze, and YANG Fan
- Subjects
high temperature tension ,physical experiment ,damage prediction ,finite element analysis ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Critical damage value of material was obtained by physical experiment combined with a finite element software. True stress-strain curve of Ti600 alloy was studied by high temperature tensile test at 1010℃ and 0.001s-1. A simplified Normalized Cockcroft & Latham ductile fracture criterion was used, in which ε and σ were substituted by ε1 and σUTS, respectively. The critical damage value of Ti600 alloy on the above experimental condition was calculated and then was embedded in a finite element software to verify its accuracy by analysing high temperature tensile process. The result shows that the critical damage value of Ti600 alloy at 1010℃ and 0.001s-1 equals 0.643. By the finite element analysis, the crack initiation and propagation are predicted well and computational variety law of minimum cross sectional area is basically agreed with the experimental law. Hence, the critical damage value of Ti600 alloy obtained by combining a Normalized Cockcroft & Latham ductile fracture criterion with a finite element software is fairly precise.
- Published
- 2019
- Full Text
- View/download PDF
3. Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity
- Author
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Herpers, Bram, Wink, Steven, Fredriksson, Lisa, Di, Zi, Hendriks, Giel, Vrieling, Harry, de Bont, Hans, and van de Water, Bob
- Published
- 2016
- Full Text
- View/download PDF
4. Ultrasonic-Assisted Extraction of Anthocyanins from Seed Skin of Adzuki Bean.
- Author
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JIN Li-mei, ZHU Cheng-cheng, YANG Si-qi, DI Zi-qing, and ZUO Feng
- Abstract
Ultrasonic-assisted ethanol solvent extraction methodology was used to extract anthocyanins from adzuki bean seed skin in this study. On the basis of single factor experiment, the effects of solid-liquid ratio, pH value, ethanol volume fraction, ultrasonic temperature, and ultrasonic power on the extraction effect of anthocyanin were investigated. Furthermore, the extraction process of adzuki bean seed skin was optimized using response surface methodology. The results showed that the priority order of factors affecting the extraction effect of anthocyanins was pH > ultrasonic temperature > ethanol concentration solid-liquid ratio, which also suggested the ultrasonic power had little effect on extraction rate. The optimum conditions for ultrasonic extraction of anthocyanins from adzuki bean seed skin were as follows: solid-liquid ratio 1 34 g/mL, pH value 3, ethanol volume fraction 30%, ultrasonic temperature 55 °C, and the ultrasonic power 350 W. Under the optimum conditions above, the extraction effect of anthocyanins from red bean seed skin reached the optimal value. The content of anthocyanins in the extraction solution reached (82.35 ± 3.28) mg/100 g. [ABSTRACT FROM AUTHOR]
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- 2022
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- View/download PDF
5. Rebalancing of the gut flora and microbial metabolism is responsible for the anti-arthritis effect of kaempferol
- Author
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Aa, Li-xiang, primary, Fei, Fei, additional, Qi, Qi, additional, Sun, Run-bin, additional, Gu, Sheng-hua, additional, Di, Zi-zhen, additional, Aa, Ji-ye, additional, Wang, Guang-ji, additional, and Liu, Chang-xiao, additional
- Published
- 2019
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6. Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant
- Author
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Catherine Kirsanova, Marcel Smid, John A. Foekens, Sylvia E. Le Dévédec, Wies van Roosmalen, Maxime P. Look, Ofra Golani, Bob van de Water, Marjo de Graauw, Di Zi, John W.M. Martens, Peter A C 't Hoen, Annemieke M. Timmermans, Chantal Pont, Gabriella Rustici, Irina Pulyakhina, Suha Naffar-Abu-Amara, Benjamin Geiger, and Medical Oncology
- Subjects
Lung Neoplasms ,Bone Neoplasms ,Breast Neoplasms ,Kaplan-Meier Estimate ,Protein Serine-Threonine Kinases ,Biology ,MAP3K8 ,Metastasis ,Focal adhesion ,Mice ,Breast cancer ,SDG 3 - Good Health and Well-being ,Cell-matrix adhesion ,Cell Movement ,Carcinoma, Non-Small-Cell Lung ,Cell Adhesion ,medicine ,Animals ,Humans ,Neoplasm Metastasis ,RNA, Small Interfering ,Cell adhesion ,Genetic Association Studies ,Focal Adhesions ,NF-kappa B ,Cell Polarity ,Nuclear Proteins ,Cell migration ,General Medicine ,Prognosis ,medicine.disease ,Neoplasm Proteins ,Gene Expression Regulation, Neoplastic ,Organ Specificity ,Cancer cell ,Cancer research ,Female ,RNA Interference ,Research Article - Abstract
Tumor cell migration is a key process for cancer cell dissemination and metastasis that is controlled by signal-mediated cytoskeletal and cell matrix adhesion remodeling. Using a phagokinetic track assay with migratory H1299 cells, we performed an siRNA screen of almost 1,500 genes encoding kinases/phosphatases and adhesome- and migration-related proteins to identify genes that affect tumor cell migration speed and persistence. Thirty candidate genes that altered cell migration were validated in live tumor cell migration assays. Eight were associated with metastasis-free survival in breast cancer patients, with integrin beta(3)-binding protein (ITGB3BP), MAP3K8, NIMA-related kinase (NEK2), and SHC-transforming protein 1 (SHC1) being the most predictive. Examination of genes that modulate migration indicated that SRPK1, encoding the splicing factor kinase SRSF protein kinase 1, is relevant to breast cancer outcomes, as it was highly expressed in basal breast cancer. Furthermore, high SRPK1 expression correlated with poor breast cancer disease outcome and preferential metastasis to the lungs and brain. In 2 independent murine models of breast tumor metastasis, stable shRNA-based SRPK1 knockdown suppressed metastasis to distant organs, including lung, liver, and spleen, and inhibited focal adhesion reorganization. Our study provides comprehensive information on the molecular determinants of tumor cell migration and suggests that SRPK1 has potential as a drug target for limiting breast cancer metastasis.
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- 2015
- Full Text
- View/download PDF
7. Electrical Properties of Nanostructured Magnetic Colloid and Influence of Magnetic Field
- Author
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Chen Xian-Feng, Xia Yu-Xing, Geng Tao, DI Zi-Yun, and PU Sheng-Li
- Subjects
symbols.namesake ,Magnetization ,Paramagnetism ,Materials science ,Magnetic energy ,Condensed matter physics ,Demagnetizing field ,symbols ,General Physics and Astronomy ,Magnetic nanoparticles ,Magnetic pressure ,Magnetic particle inspection ,Nernst effect - Abstract
We investigate the electrical properties of the nanostructured magnetic colloid without and with magnetic field. The competition between the directional motion of the charged magnetic nanoparticles and other minor nonmagnetic impurities (also small amount of ions) under applied voltage and their random orientation due to thermal activation is implemented to elaborate the electrically conduction mechanism under zero magnetic field. Two equivalent electric circuits are employed for explaining the charging and discharging processes. The tunnelling conduction mechanism upon application of externally magnetic field may exist in the nanostructured magnetic colloid. The alternation of the two conduction mechanisms accounts for the current spikes when the magnetic field is switched on or off. This work presents the peculiar electrical phenomena of the magnetically colloidal system.
- Published
- 2007
- Full Text
- View/download PDF
8. Phylogenetic studies of two Anas platyrhynchos (Anatini: Anatinae) in Hunan province of China based on complete mitochondrial DNA sequences
- Author
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Ya-Ting Yuan, De-Xing Hou, Xi He, Rong Cao, Shi-Rui Zhang, Di-Zi Pan, Long Yun, and Qian Lin
- Subjects
0301 basic medicine ,Anas ,Mitochondrial DNA ,China ,Population ,Zoology ,Genome ,DNA, Mitochondrial ,03 medical and health sciences ,Open Reading Frames ,Genome Size ,Anserinae ,Anseriformes ,Genetics ,Animals ,education ,Molecular Biology ,Phylogeny ,education.field_of_study ,Base Composition ,Anatinae ,biology ,Phylogenetic tree ,Whole Genome Sequencing ,Anatomy ,Sequence Analysis, DNA ,biology.organism_classification ,Breed ,030104 developmental biology ,Genes, Mitochondrial ,Genome, Mitochondrial - Abstract
In this study, we cloned and sequenced the complete mitochondrial DNAs of Chinese duck, Anas platyrhynchos, population from two different areas of Hunan province in China. The Anas platyrhynchos breed Linwu duck (LW) sample was taken from the Linwu county of Chenzhou city, and the Anas platyrhynchos breed Youxian duck (YX) sample was taken from the Youxian county of Zhuzhou city. The lengths of their complete mitochondrial genome were 16,604 bp (LW) and 16,606 bp (YX), respectively. The organization of the two Anas platyrhynchos breed mitochondrial genomes was similar to those reported from other duck mitochondrial genomes. Phylogenetic analyses using N–J computational algorithms showed that the analyzed species are divided into four major clades: Anatinae, Anserinae, Dendrocygninae and Anseranatidae. Also, the Linwu duck and Youxian duck have highly similar phylogenetic relationship.
- Published
- 2015
9. Phylogenetic studies of two Anas platyrhynchos (Anatini: Anatinae) in Hunan province of China based on complete mitochondrial DNA sequences
- Author
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He, Xi, primary, Lin, Qian, additional, Cao, Rong, additional, Yuan, Ya-Ting, additional, Pan, Di-Zi, additional, Yun, Long, additional, Zhang, Shi-Rui, additional, and Hou, De-Xing, additional
- Published
- 2015
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- View/download PDF
10. Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity
- Author
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Herpers, Bram, primary, Wink, Steven, additional, Fredriksson, Lisa, additional, Di, Zi, additional, Hendriks, Giel, additional, Vrieling, Harry, additional, de Bont, Hans, additional, and van de Water, Bob, additional
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- 2015
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11. Ultra High Content Image Analysis and Phenotype Profiling of 3D Cultured Micro-Tissues
- Author
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Di, Zi, primary, Klop, Maarten J. D., additional, Rogkoti, Vasiliki-Maria, additional, Le Dévédec, Sylvia E., additional, van de Water, Bob, additional, Verbeek, Fons J., additional, Price, Leo S., additional, and Meerman, John H. N., additional
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- 2014
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12. Automated Analysis of NF-κB Nuclear Translocation Kinetics in High-Throughput Screening
- Author
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Di, Zi, primary, Herpers, Bram, additional, Fredriksson, Lisa, additional, Yan, Kuan, additional, van de Water, Bob, additional, Verbeek, Fons J., additional, and Meerman, John H. N., additional
- Published
- 2012
- Full Text
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13. ‘Single mode’ tunable optical microcavities
- Author
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Di, Zi-Yun, primary, Dolan, Philip R., additional, Jones, Helene V., additional, Hughes, Gareth M., additional, and Smith, Jason M., additional
- Published
- 2012
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14. Chapter Repression of the future-oriented disposition of Italians by a never-ending pandemic
- Author
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Di Zio, Simone and Fabbris, Luigi
- Subjects
Future orientation ,Covid-19 pandemic ,Depression ,Pro-activeness ,bic Book Industry Communication::J Society & social sciences - Abstract
Likely, the after-pandemic world won’t be as it used. To properly imagine and build our future, we should forget the progressive growth of past times and even the concept of “normality” of pre-pandemic years is going to change inasmuch as a new social concept is coming true ("surprise free" scenarios are no longer contemplated). The disposition of Italians towards their future was surveyed with three indicators: 1) the depression rate as measured with PHQ9, a standard psychological test for clinical depression measurement; 2) the pro-activeness orientation, as measured with an 8-item psychological test; and 3) the clearness rate of own future vision, as measured with a focused, dichotomous question. The indicators have been measured through a convenience sample on Italian adults during the second half of 2021. The analysis showed that the fear of contagion and the never-ending emergency due to Covid-19 pandemic caused such a psychological awkwardness to repress the disposition of Italians towards their possible futures. The repression was harder on youngsters, living alone persons, disrupted families, and people with psychic and/or depressive symptoms. A regressive model was furtherly fit on the collected sample. It showed multiple determinants of the future repression, say, that the fear of contagion was more relevant than the contagion itself and the uncertainty about the pandemic end was as disheartening as the contagion risk for the yearning hope of a positive after-pandemic lifestyle.
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- 2023
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15. Chapter Remote working in Italy: Just a pandemic accident or a lesson for the future?
- Author
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Bollani, Luigi, Di Zio, Simone, and Fabbris, Luigi
- Subjects
Remote working ,Covid-19 pandemic ,Psychological disposition ,Work-family balance ,Employee socialisation ,Job schedule ,bic Book Industry Communication::J Society & social sciences - Abstract
During the Covid-19 pandemic, remote working (RW) has been a way to producing despite limiting contacts. In Italy, about a half of the workers experienced, at least for a part of their working time, RW during the years 2020 and 2021. In this paper we analyse the data collected through a web-based survey conducted in the second half of 2021 at a convenience sample of Italian adults. The survey was aimed at highlighting how Italians experienced the pandemic and how they perceived their future. Also, we measured the frequency and the intensity of the RW phenomenon, the feelings of those who practiced and the opinion of workers about the possibility to practice it in the future. The data show that so many adults practiced RW during the pandemic. Their judgement of the experience is largely positive: 60.8% stated they were inclined to pursue it again as a normal work strategy. Though, there are distinctions. The type of job and the recent experience entail people’s commitment towards RW. Even what people expect from work may influence their disposition to take in RW as normal. The convolution of wells of the RW disposition, scouted through a multivariate statistical analysis, showed that, on top of the well-known suitability of RW to certain job types (white-collar, gig activities, self-employed), the workers’ propensity to RW is higher if commuting cost saving, own time optimisation and not-too-open schedules, work-family balance and a free time surplus, the possibility of interaction and socialisation with other company’s employees and customers and a secure web connection characterise their jobs.
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- 2023
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16. Chapter New perspectives for the quality of sub-municipal data with the Italian permanent population and housing census
- Author
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Daddi, Stefano, De Matteis, Giampaolo, Fardelli, Davide, Lipizzi, Fabio, Carbonetti, Giancarlo, Di Zio, Marco, Galliera, Raffaele, and Orsini, Enrico
- Subjects
population census ,administrative data ,statistical registers ,geo-coding ,enumeration area ,missing data ,data quality ,bic Book Industry Communication::J Society & social sciences - Abstract
Over the years, official statistics have shown increasing attention to the territory in providing detailed and quality information and, in this sense, the Population and Housing Census has always guaranteed the availability of sub-municipal data useful for decision-making processes in the social, economic and environmental fields. The Istat modernization programme introduced the Permanent Census that, differently from the traditional decennial census essentially drew on collecting data from people, is strongly based on the integration of administrative and sample data, and planned for providing yearly statistical figures. This change requires new methodological and IT architectures. It is a revolution that – on the medium term – is expected to provide more stable and coherent figures at various territorial levels.In this framework, sub-municipal data derives from the integration of the Basic Register of Individuals and the Basic Register of Places. The quality of data depends on the quality of the Registers and the procedures adopted to integrate and elaborate input data. In this regard, Istat is working to improve the geocoding information and linkage procedures. One of the problem encountered is that of non-geocoded units. These are units without an allocation into an enumeration area because of problems in administrative data. Istat has studied a procedure integrating deterministic and probabilistic approaches for assigning the enumeration area to those critical units. An experimental study is carried out to evaluate the quality of the imputation procedure. In this paper, we discuss the approach adopted, the evaluation process, the results obtained and the impact on the quality of the data and the spatial analyses that can be carried out.
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- 2023
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17. Chapter Individual and social aspects of after-Covid-19 pandemic depression
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Anselmi, Pasquale, Colledani, Daiana, Di Zio, Simone, Fabbris, Luigi, and Robusto, Egidio
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Depression ,Covid-19 ,Individual and social aspects ,bic Book Industry Communication::J Society & social sciences - Abstract
How did individual and social aspects influence depression feelings during the pandemic? In this paper, we analyse the data collected through a survey conducted in the second half of 2021 among a convenience sample of Italian adults. The survey was aimed at highlighting how Italians experienced the pandemic and the way they perceived their future. A total of 556 Italians answered the CAWI survey. The analyses of the collected data show that, while having been infected by the virus or having had a family member infected by it did not influence the depression level, other individual characteristics and subjective feelings did. In particular, being female, younger, having had low trust in information delivered by television, no experiences of smart working or remote learning, little support from friends and family, and being unable to imagine the future increased the likelihood to feel higher levels of depression. Being able to imagine the future mediated the relationships of age and smart working or remote learning experiences with depression. The results indicate that, having a lower ability to imagine the future, younger people and individuals who did not work or study remotely have also a greater tendency to feel depressed.
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- 2023
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18. Chapter Are Italian youngsters adequately equipped for an after-pandemic upswing?
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Bollani, Luigi, Di Zio, Simone, and Fabbris, Luigi
- Subjects
Youngsters ,Depression ,Future ,Apathy ,Proactive ,bic Book Industry Communication::J Society & social sciences - Abstract
Are Italian youngsters adequately equipped for an after-pandemic upswing?All over the world young people seem to be particularly dazed by the Covid-19 pandemic. Indeed, they were touched just lightly by the disease, though the isolation due to the distancing need and the remote learning mode may be the sources of depressive ailments and other psychological distresses. In this paper we analyse the data collected through a survey conducted in the second half of 2021 among a convenience sample of Italian adults. The survey was aimed at highlighting how Italians experienced the pandemic and the way they perceived their futures. About one third of the sample was below 35 and we consider them the young. Most of them were students, a few worked, some were looking for a job. The analysis of the collected data shows that so many young Italians were disturbed by the pandemic, even though the sanitary impact of the disease on them was much less relevant than other age classes. Among the youngsters, the depression and anxiety rates was significantly higher than other adults, the perception of a future role was limited to them and their potential resources for future life was also jeopardized. The possible causes of the reduction capacity among young adults was scouted through a multivariate statistical analysis. It showed that the perception of personal difficulties is correlated to a feeling of uncertainty for their future roles, to a pressure over their social-economical and personal resources to face their future and to a sort of apathy that could limit their pro-activeness.
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- 2023
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19. Chapter A Natural Language Processing approach to measure expertise in the Delphi-based scenarios
- Author
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Calleo, Yuri, Di Zio, Simone, and Pilla, Francesco
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future scenarios ,Delphi ,expertise assessment ,bic Book Industry Communication::J Society & social sciences - Abstract
The Delphi-based scenarios (DBS) development implies the assumption of different choices, through the gathering of information and the assessment of alternative resolutions (Panpatte and Takale, 2019). During the last decades, the spread of environmental hazards has increased quickly, much to request different responses in order to develop a sustainable future for humanity planning the present (McMichael and Lindgren, 2011). Since the DBS is a creative process (Nowack et al., 2011), different figures are selected to make choices, including academics, stakeholders and citizens. However, one of the main challenges remains the measurement of expertise, in fact, during the process, the experts should be assessed based on their competences in order to avoid any conflict in the final results and, eventually, weigh their answers. In recent years, some contributions adopted the self-assessments for the experts’ evaluation (Sossa et al., 2019), but many issues still remain (such as strong subjectivity and cognitive biases which produce over or underestimation). We develop a new method to estimate the expertise by using Natural Language Processing to acquire information, extracting the contributions of experts in each topic. First, starting from a draft list of selected experts, we identify the category of reference (e.g., academia, industry, local authority, citizens etc.). We build a data repository with the personal pages (URLs) of each expert to then use Python to extract from the URLs, the number of contributions related to a keyword, different for each category (e.g., publications for academics, reports and projects for stakeholders etc.). Finally, we proceed adopting a coefficient of production with a weighted sum of the results. To practically demonstrate our approach, we applied this method to a cohort of known experts, part of the “Smart control of the climate resilience” (SCORE) H2020 European project to estimate their expertise in specific areas.
- Published
- 2023
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20. Electrical Properties of Nanostructured Magnetic Colloid and Influence of Magnetic Field.
- Author
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Pu Sheng, Chen Xian, Di Zi, Geng Tao, and Xia Yu
- Subjects
MAGNETIC fields ,COLLOIDS ,DIFFUSION ,PROPERTIES of matter - Abstract
We investigate the electrical properties of the nanostructured magnetic colloid without and with magnetic field. The competition between the directional motion of the charged magnetic nanoparticles and other minor nonmagnetic impurities (also small amount of ions) under applied voltage and their random orientation due to thermal activation is implemented to elaborate the electrically conduction mechanism under zero magnetic field. Two equivalent electric circuits are employed for explaining the charging and discharging processes. The tunnelling conduction mechanism upon application of externally magnetic field may exist in the nanostructured magnetic colloid. The alternation of the two conduction mechanisms accounts for the current spikes when the magnetic field is switched on or off. This work presents the peculiar electrical phenomena of the magnetically colloidal system. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
21. Chapter Unsupervised spatial data mining for the development of future scenarios: a Covid-19 application
- Author
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Calleo, Yuri and Di Zio, Simone
- Subjects
text-mining ,spatial analysis ,scenario development ,georeferenced textual data ,covid-19 - Abstract
In the context of Futures Studies, the scenario development process permits to make assumptions on what the futures can be in order to support better today decisions. In the initial stages of the scenario building (Framing and Scanning phases), the process requires much time and efforts to scanning data and information (reading of documents, literature review and consultation of experts) to understand more about the object of the foresight study. The daily use of social networks causes an exponential increase of data and for this reason here we deal with the problem of speeding up and optimizing the Scanning phase by applying a new combined method based on the analysis of tweets with the use of unsupervised classification models, text-mining and spatial data mining techniques. For the purpose of having a qualitative overview, we applied the bag-of-words model and a Sentiment Analysis with the Afinn and Vader algorithms. Then, in order to extrapolate the influence factors, and the relevant key factors (Kayser and Blind, 2017; 2020) the Latent Dirichlet Allocation (LDA) was used (Tong and Zhang, 2016). Furthermore, to acquire also spatial information we used spatial data mining technique to extract georeferenced data from which it was possible to analyse and obtain a geographic analysis of the data. To showcase our method, we provide an example using Covid-19 tweets (Uhl and Schiebel, 2017), upon which 5 topics and 6 key factors have been extracted. In the last instance, for each influence factor, a cartogram was created through the relative frequencies in order to have a spatial distribution of the users discussing each particular topic. The results fully answer the research objectives and the model used could be a new approach that can offer benefits in the scenario developments process.
- Published
- 2021
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22. Chapter Reducing inconsistency in AHP by combining Delphi and Nudge theory and network analysis of the judgements: an application to future scenarios
- Author
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Di Zio, Simone
- Subjects
Analytic Hierarchy Process ,Delphi ,Nudge theory ,Inconsistency ,Graphs ,bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology::JHBC Social research & statistics - Abstract
The Analytic Hierarchy Process (AHP) is a Multi-Criteria method in which a number of decision factors (typically criteria and alternatives) are compared pairwise by one or more experts, using the Saaty scale, with the goal of sorting the alternatives (Saaty, 1977; 1980). For group AHP the Delphi method can be used in parallel with the AHP (Di Zio and Maretti, 2014), and this allows the search for a consensus on each pairwise judgement. A big issue of the AHP regards the inconsistency of the pairwise comparison matrices and here we propose a new method to reduce the inconsistency. As a solution we exploit the Nudge theory (Thaler and Sunstein, 2008) and from the second round of the Delphi survey, we calculate and circulate a Nudge to “gentle push” the experts towards more consistent evaluations. Furthermore, we propose the representation of the AHP matrices through graphs. In a direct graph two nodes are linked with two direct and weighted edges (or one edge with the direction based on the weights), where the weights indicate the evaluation given by an expert or, for a group, the geometric mean of the judgements. This type of visualization facilitates the reading of the results and could also be used as real-time feedback in the Delphi process, by displaying on the edges also a measure of variability. An application is proposed, on the evaluation of four future scenarios on the regulation of genetic modification experiments, assessed by a panel of 27 experts according to different criteria (plausibility, consistency and simplicity). The application demonstrated that it is possible to: a) reduce the inconsistency; b) collect useful textual material which enrich the AHP itself; c) use the inconsistency index as a stopping criterion for the Delphi rounds; d) display the pairwise comparison matrices with graphs.
- Published
- 2021
- Full Text
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23. General and renal toxicity of phenacetin, paracetamol and some anti-mitotic agents in the rat
- Author
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Peters, G., primary, Baechtold-Fowler, Nicole, additional, Bonjour, J. Ph., additional, Chom�ty-Di�zi, Fran�oise, additional, Filloux, Bernadette, additional, Guidoux, R., additional, Guignard, J. P., additional, Peters-Haefeli, Lise, additional, Roch-Ramel, Fran�oise, additional, Schelling, J. L., additional, Hedinger, Chr., additional, and Weber, Erika, additional
- Published
- 1972
- Full Text
- View/download PDF
24. Phylogenetic studies of two Anas platyrhynchos (Anatini: Anatinae) in Hunan province of China based on complete mitochondrial DNA sequences.
- Author
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He, Xi, Lin, Qian, Cao, Rong, Yuan, Ya-Ting, Pan, Di-Zi, Yun, Long, Zhang, Shi-Rui, and Hou, De-Xing
- Subjects
BIRD phylogeny ,MALLARD ,BIRDS ,MITOCHONDRIAL DNA ,NUCLEOTIDE sequencing ,TRANSFER RNA ,RIBOSOMAL RNA - Abstract
In this study, we cloned and sequenced the complete mitochondrial DNAs of Chinese duck,Anas platyrhynchos, population from two different areas of Hunan province in China. TheAnas platyrhynchosbreed Linwu duck (LW) sample was taken from the Linwu county of Chenzhou city, and theAnas platyrhynchosbreed Youxian duck (YX) sample was taken from the Youxian county of Zhuzhou city. The lengths of their complete mitochondrial genome were 16,604 bp (LW) and 16,606 bp (YX), respectively. The organization of the twoAnas platyrhynchosbreed mitochondrial genomes was similar to those reported from other duck mitochondrial genomes. Phylogenetic analyses using N–J computational algorithms showed that the analyzed species are divided into four major clades: Anatinae, Anserinae, Dendrocygninae and Anseranatidae. Also, the Linwu duck and Youxian duck have highly similar phylogenetic relationship. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
25. ‘Single mode’ tunable optical microcavities.
- Author
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Di, Zi-Yun, Dolan, Philip R., Jones, Helene V., Hughes, Gareth M., and Smith, Jason M.
- Abstract
We present tunable open-access optical microcavities with mode volumes ∼ λ3 and Q factors ∼ 104. Purcell enhancement of emission from semiconductor nanocrystals into single cavity modes at room temperature is demonstrated. [ABSTRACT FROM PUBLISHER]
- Published
- 2012
26. Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant.
- Author
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van Roosmalen, Wies, Le Dévédec, Sylvia E., Golani, Ofra, Smid, Marcel, Pulyakhina, Irina, Timmermans, Annemieke M., Look, Maxime P., Di Zi, Pont, Chantal, de Graauw, Marjo, Nafar-Abu-Amara, Suha, Kirsanova, Catherine, Rustici, Gabriella, 't Hoen, Peter A. C., Martens, John W. M., Foekens, John A., Geiger, Benjamin, and van de Water, Bob
- Subjects
- *
CANCER cell migration , *GENETICS of breast cancer , *CANCER invasiveness , *METASTASIS , *LABORATORY mice , *GENETICS - Abstract
Tumor cell migration is a key process for cancer cell dissemination and metastasis that is controlled by signal-mediated cytoskeletal and cell matrix adhesion remodeling. Using a phagokinetic track assay with migratory H1299 cells, we performed an siRNA screen of almost 1,500 genes encoding kinases/phosphatases and adhesome- and migration-related proteins to identify genes that affect tumor cell migration speed and persistence. Thirty candidate genes that altered cell migration were validated in live tumor cell migration assays. Eight were associated with metastasis-free survival in breast cancer patients, with integrin β3-binding protein (ITGB3BP), MAP3K8, NIMA-related kinase (NEK2), and SHC-transforming protein 1 (SHC1) being the most predictive. Examination of genes that modulate migration indicated that SRPK1, encoding the splicing factor kinase SRSF protein kinase 1, is relevant to breast cancer outcomes, as it was highly expressed in basal breast cancer. Furthermore, high SRPK1 expression correlated with poor breast cancer disease outcome and preferential metastasis to the lungs and brain. In 2 independent murine models of breast tumor metastasis, stable shRNA-based SRPK1 knockdown suppressed metastasis to distant organs, including lung, liver, and spleen, and inhibited focal adhesion reorganization. Our study provides comprehensive information on the molecular determinants of tumor cell migration and suggests that SRPK1 has potential as a drug target for limiting breast cancer metastasis. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
27. [Value of cardiac CT in the diagnostic work-up of coronary artery disease : Update 2017].
- Author
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Meyer M and Henzler T
- Subjects
- Coronary Stenosis diagnostic imaging, Humans, Coronary Angiography methods, Coronary Artery Disease diagnostic imaging, Tomography, X-Ray Computed methods
- Abstract
The quantification of coronary calcifications using noncontrast-enhanced computed tomography (CT) as well as coronary CT angiography (cCTA) have rapidly evolved in the recent years. Nowadays, both techniques are increasingly clinically accepted regarding risk stratification and accurate exclusion of significant coronary artery disease (CAD). The higher acceptance of cCTA is mainly based on the higher robustness, lower radiation exposure through continuous technical innovations as well as by the growing scientific evidence. The poor predictive value of cCTA for predicting the hemodynamic significance of detected coronary artery stenosis may be improved by continuous technical developments in the area of functional imaging. The aim of this educational article is to summarize the current clinical status of calcium scoring and morphological cCTA and to provide an overview on novel functional CT techniques.
- Published
- 2017
- Full Text
- View/download PDF
28. Epidemiological profile and postoperative complications of women undergoing gynecological surgery in a reference center in the northern Brazilian legal Amazon.
- Author
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Coelho SM, Perez Ede L, Lins CD, Gomes MT, Bella ZI, Andres Mde P, and Podgaec S
- Subjects
- Adult, Brazil, Female, Humans, Middle Aged, Pregnancy, Retrospective Studies, Suburethral Slings, Gynecologic Surgical Procedures, Postoperative Complications
- Abstract
Objective: To evaluate the epidemiological profile and the operative complications of patients undergoing gynecological operations for benign diseases in a tertiary public hospital in the state of Roraima, Brazil., Methods: We conducted a retrospective survey through the analysis of 518 records of patients submitted to gynecological operations between January and June 2012. We included the three major operations during this period (n = 175): hysterectomy, colpoperineoplasty and suburethral sling placement. We excluded 236 cases of tubal ligation and 25 cases where it was not possible to access to medical records., Results: The mean age was 47.6 years; the education level of most patients was completed junior high (36.6%); 77% were from the State capital, 47.4% were in stable relationships and 26.3% were housewives. The majority of patients had given birth three or more times (86.6%), with previous vaginal delivery in 50.2%, and cesarean delivery, 21%. The main diagnostic indications for surgical treatment were uterine myoma (46.3%), urinary incontinence (27.4%) and genital dystopias (17.7%). We found three cases (1.7%) of high-grade intraepithelial lesions on Pap smear. The most common procedure was total hysterectomy (19.8%), 15.5% vaginally. The most common complication was wound infection (2.2%)., Conclusion: Women undergoing gynecological operations due to benign disease had a mean age of 47 years, most had levels of basic education, came from the capital, were in stable relationships, predominantly housewives, multiparous and showed low operative complication rates.
- Published
- 2015
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29. [Influence of body mass index, body fat percentage and age at menarche on aerobic capacity (VO₂ max) of elementary school female students].
- Author
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Capel TL, Vaisberg M, Araujo MP, Paiva RF, Santos Jde M, and Bella ZI
- Subjects
- Adolescent, Age Factors, Child, Cross-Sectional Studies, Female, Humans, Students, Adipose Tissue, Body Mass Index, Menarche, Oxygen metabolism
- Abstract
Purpose: To identify and relate body fat percentage (skin fold measures), body mass index (BMI) and age at menarcheto aerobic capacity using the indirect VO₂ maximum value (VO₂ max) of girls in the second cycle of primary school., Methods: A total of 197 girls aged 13.0 ± 1.2 years on average, students from two public schools in the city of Atibaia in São Paulo, were evaluated. Anthropometric evaluation of skin folds was performed using the Slaughter protocol for teenage girls, and BMI (kg/m²) was based on "Z score" (graphic of percentile) according to WHO recommendations. The Léger protocol was used to determine VO₂ max. Pearson linear regression and the Student t-test were used for statistical analysis., Results: 22.3% of the girls were overweight and 3.5% were obese according to the classification proposed by the WHO; 140 (71.1%) girls reported menarche. The average age at menarche was 12.0 ± 1.0 years and was significantly higher in the group with normal BMI (12.2 ± 0.9 years) than in the overweight or obese groups (11.6 ± 1.0 years). The average indirect VO₂ max value was 39.6 ± 3.7 mL/kg/min, ranging from 30.3 to 50.5 mL/kg/min. The advance of chronological age and early age at menarche were positively correlated with lower VO₂ max values., Conclusions: This study showed that 25.8% of the girls had aBMI value above WHO recommendations. Girls with higher BMI and higher body fat percentage had lower VO₂ max. The earlier age at menarche and the advance of chronological age were the most important factors for the reduction of aerobic capacity. The ageat menarche was higher in girls with adequate BMI compared tooverweight or obese girls.
- Published
- 2014
30. Efficacy of pelvic floor muscle training and hypopressive exercises for treating pelvic organ prolapse in women: randomized controlled trial.
- Author
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Bernardes BT, Resende AP, Stüpp L, Oliveira E, Castro RA, Bella ZI, Girão MJ, and Sartori MG
- Subjects
- Epidemiologic Methods, Female, Humans, Middle Aged, Pelvic Floor diagnostic imaging, Ultrasonography, Exercise Therapy methods, Muscle Contraction physiology, Muscle, Skeletal physiology, Pelvic Floor physiology, Pelvic Organ Prolapse therapy
- Abstract
Context and Objective: Previous studies have shown that women with pelvic floor dysfunctions present decreased cross-sectional area (CSA) of the levator ani muscle. One way to assess the effects of training programs is to measure the CSA of the muscle, using ultrasonography. The aim here was to evaluate the efficacy of pelvic floor muscle training and hypopressive exercises for increasing the CSA of the levator ani muscle in women with pelvic organ prolapse., Design and Setting: Prospective randomized controlled trial at the Urogynecology outpatient clinic of Universidade Federal de São Paulo., Methods: Fifty-eight women with stage II pelvic organ prolapse were divided into three groups for physiotherapy: a pelvic floor muscle training group (GI); a hypopressive exercise group (GII); and a control group (GIII). The patients underwent transperineal ultrasonographic evaluation using a transducer of frequency 4-9 MHz. The (CSA) of the levator ani muscle was measured before physiotherapy and after 12 weeks of treatment., Results: The groups were homogeneous regarding age, number of pregnancies, number of vaginal deliveries, body mass index and hormonal status. Statistically significant differences in CSA were found in GI and GII from before to after the treatment (P < 0.001), but not in relation to GIII (P = 0.816)., Conclusions: The CSA of the levator ani muscle increased significantly with physiotherapy among the women with pelvic organ prolapse. Pelvic floor muscle training and hypopressive exercises produced similar improvements in the CSA of the levator ani muscle.
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- 2012
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31. [Retropubic and transobturator sling in treatment of stress urinary incontinence].
- Author
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Tanuri AL, Feldner PC Jr, Bella ZI, Castro RA, Sartori MG, and Girão MJ
- Subjects
- Female, Follow-Up Studies, Humans, Statistics, Nonparametric, Treatment Outcome, Urinary Incontinence, Stress physiopathology, Urodynamics physiology, Urologic Surgical Procedures methods, Quality of Life, Suburethral Slings, Urinary Incontinence, Stress surgery, Urologic Surgical Procedures adverse effects
- Abstract
Objective: To compare the results of retropubic and transobturator slings for surgical treatment of female stress urinary incontinence (SUI)., Methods: We randomized thirty patients with SUI, ten of whom underwent transobturator sling surgery and ten retropubic sling surgery. Patients were assessed before treatment and 1, 6 and 12 months after treatment on the basis of clinical history, physical examination, quality of life questionnaire (King's Health Questionnaire), pad test and urodynamic evaluation. The groups were homogenous prior to surgery., Results: One year after surgery, incontinence and quality of life parameters had improved significantly in both groups and there were no differences between them. There was a significant reduction in pad test weights in both groups. According to the urodynamic evaluation, 12 months after surgery cure rates were 84.2% for the transobturator group and 88.8% for the retropubic group. Subjective cure rates were 85% in the transobturator group and 88.8% in the retropubic group. No statistical difference was observed in complication rates., Conclusion: Retropubic and transobturator slings were effective for treatment of women with SUI at 12-month follow-up. Both techniques had significant cure rates and improved quality of life with low complication rates.
- Published
- 2010
- Full Text
- View/download PDF
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