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159 results on '"Di Summa M"'

9. [Hospital mortality at a cardiosurgical unit in Torino: international comparisons and time trend]

Author

Ciccone, G., Bobbio, M., DI SUMMA, M., Poletti, G., Pandolfo, G., Piobbici, M., Centofanti, P., Grasso, E., Buono, G., Verdecchia, C., Pansini, S., Castenetto, E., Roggero, S., Arione, R., Merletti, Franco, and Terracini, B.

Subjects
Adult, Aged, 80 and over, Male, Adolescent, Italy, Humans, Female, Hospital Mortality, Cardiac Surgical Procedures, Middle Aged, Global Health, Aged
Abstract

To compare hospital mortality in a cardiac surgery unit with external data and to assess changes in time (patients undergoing surgery in two different periods).Data on risk factors for hospital mortality were collected from clinical records (retrospectively for the first period and prospectively for the second) for all patients undergoing open heart surgery at the Heart Surgery Unit of the University of Turin (Italy) during 1991 and 1995 (n = 1794) and 1999 (n = 892). Comparisons of in-hospital mortality, expressed as Standardized Mortality Ratios (SMR), were adjusted for risk factors defined according to EuroSCORE (European System for Cardiac Operative Risk Evaluation).In the first and second period, complete information on all the 17 EuroSCORE items was available for 58.3% and 89.6% patients respectively. After exclusion of patients with one or more missing data, observed and expected numbers of death were found to be very similar, with SMRs ranging between 0.82 (isolated bypass in the second period) and 1.06 ("other" surgery in the first period). Mortality was higher among patients with missing data, but at least in 1999 the latter had a limited impact on the overall estimates. Compared to the first period, mortality was reduced during 1999 (from 5.9% to 5.4%), in particular for isolated bypass (from 4.4% to 3.4%).In the unit under investigation, hospital mortality following heart surgery was similar to that predicted from EuroSCORE and seemed to be lower in 1999 than in 1991-95, particularly for isolated bypass. Incompleteness of data on individual risk factors may have been a source of bias, especially when data were collected retrospectively.

Published
2004

11. Optimal solutions for the balanced minimum evolution problem

Author

ULB - Département d’Informatique, Aringhieri, R., Catanzaro, Daniele, Di Summa, M., ULB - Département d’Informatique, Aringhieri, R., Catanzaro, Daniele, and Di Summa, M.

Abstract

Phylogenies are trees representing the evolutionary relationships of a set of species (called taxa). Phylogenies find application in several scientific areas ranging from medical research to drug discovery, epidemiology, systematics and population dynamics. In these applications the available information is usually restricted to the leaves of a phylogeny and is represented by molecular data extracted from the species analyzed. On the contrary, the information about the phylogeny itself is generally missing and must be determined by solving an optimization problem, called the phylogeny estimation problem (PEP), whose versions depend on the criterion used to select a phylogeny among plausible alternatives. In this paper, we investigate one of the most significant versions of the PEP, called the balanced minimum evolution problem. We propose an exact algorithm based on the enumeration of non-isomorphic trees and the subsequent solution of quadratic assignment problems. Furthermore, by exploiting the underlying parallelism of the algorithm, we present a parallel version of the algorithm which shows a linear speed-up with respect to the sequential version. Extensive computational results prove the effectiveness of the proposed algorithms.

Published
2011

19. Histologic and molecular diagnosis of myocardial human cytomegalovirus infection after heart transplantation

Author

Angela Pucci, Ghisetti V, Donegani E, Barbui A, David E, Fortunato M, Papandrea C, Pansini S, Zattera G, and di Summa M

Subjects
Graft Rejection, Biopsy, Myocardium, Cytomegalovirus, Heart, Opportunistic Infections, Antibodies, Viral, Immunohistochemistry, Polymerase Chain Reaction, Cytomegalovirus Infections, DNA, Viral, Heart Transplantation, Humans, Viremia, In Situ Hybridization, Endocardium
Abstract

A total of 879 paraffin-embedded endomyocardial biopsy specimens from 69 heart transplant recipients were studied. In 30 biopsy specimens, the presence of human cytomegalovirus was investigated by routine histologic and immunohistochemical evaluation, in situ hybridization, and polymerase chain reaction. These 30 biopsies were performed in seven patients with clinical human cytomegalovirus infection (four primary and three recurrent infections) and in eight patients with asymptomatic human cytomegalovirus recurrent infection. These endomyocardial biopsy specimens showed grade 0 (n = 9), 1A (n = 12), 1B (n = 7), or 2 (n = 2) acute rejection. No myocarditis with human cytomegalovirus-like inclusion bodies was observed by routine histologic evaluation. Human cytomegalovirus DNA or antigens were not shown by in situ hybridization or by immunohistochemical evaluation, respectively. Viral DNA was detected by polymerase chain reaction in two grade 1A endomyocardial biopsy specimens from two patients with systemic human cytomegalovirus primary infection. These two biopsy specimens were shown to be positive by polymerase chain reaction at the time of the acute phase of the infection as shown by laboratory findings. Therefore cytomegalovirus DNA detected by polymerase chain reaction could result from viral carriers, that is, leukocytes of rejection-related infiltrates or within intramyocardial vessels as a result of a more aggressive expression of the systemic infection in seronegative recipients with cytomegalovirus seropositive donors. Polymerase chain reaction is the most sensitive method for viral DNA detection on paraffin-embedded biopsy specimens, but a multitechnologic approach, including routine histologic evaluation, is required for a proper diagnosis of human cytomegalovirus myocardial infection.

Published
1994

26. Coronary artery bypass grafting for unstable angina. Risk factors of operative mortality

Author

Ottino, Gm, Di Summa, M, Poletti, Ga, Comoglio, Chiara, Donegani, E, Zussa, C, Musumeci, F, and Morea, M.

Subjects
Adult, Male, Risk, Age Factors, Stroke Volume, Middle Aged, Angina Pectoris, Hypertension, Humans, Female, Angina, Unstable, Coronary Artery Bypass, Emergencies, Aged
Abstract

In order to identify factors affecting early mortality in patients undergoing CABG for unstable angina, several risk factors have been analysed in a group of 120 patients. Systemic hypertension and left ventricular impairment were shown to be significant risk factors (Systemic hypertension, P less than 0.01; EF less than or equal to 0.35, P less than 0.01; LVEDP greater than or equal to 20 mmHg, P less than 0.025). Overall mortality rate was 5% (6/120). No influence could be recognized for age, sex, previous MI, emergency surgery, extension of coronary disease, completeness of revascularization and mode of onset of symptoms.

Published
1984

29. Vascular complications associated with a large cardiac fibroma.

Author

Patanè, F, Zingarelli, E, Verzini, A, and di Summa, M

Abstract

A case is reported of a 30-year-old patient with an intrapericardial tumour with heart failure. After the diagnostic protocol, surgery was performed initially without extra-corporeal circulation (ECC). Due to the location, size and to the large connection with the most important vascular structures, the ascending aorta ruptured accidentally during resection and was replaced after using ECC in emergency. The post-surgical course was regular and the tumour was identified histologically as a fibroma.

Published
2001
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30. Are the Duke criteria really useful for the early bedside diagnosis of infective endocarditis? Results of a prospective multicenter trial

Author

Cecchi, E., Trinchero, R., Imazio, M., Forno, D., Dal Conte, I., Lipani, F., Brusca, A., Gnavi, R., Bobbio, M., Di Perri, G., Caramello, P., Veglio, V., Soranzo, M. L., Mangiardi, L., Commodo, E., Trevi, G. P., Tidu, M., Chinaglia, A., Pomari, F., Demichelis, B., Biancochinto, F., Preziosi, C., Ugliengo, G., Patrone, M., Ricchiardi, E., Ambrogio, V., Aloi, N., Madama, G., Leonardi, G., Sturlese, U., Perotti, L., Riva, L., Subrizi, M., Tassani, G., Dalmasso, M., Ravera, A., D Arrigo, A., Parrini, I., Giacosa, M., Gioria, A., Petronio, M., Angelino, P., Conte, M. R., Avonto, L., Pecchio, F., Baralis, G., Demarie, D., Ghisio, A., Moratti, M., Coda, L., Costanzo, P., Ferro, S., Francesco Giuseppe DE ROSA, Morello, M., Calachanis, M., Bernasconi, C., Checco, L., Emanuelli, G., Peano, P., Pagano, G. F., Schino, P., Bonino, G., Di Summa, M., Forsennati, P. G., Actisdato, G. G., Pasquino, M., Santoro, V., Perin, P. C., Crosazzo, C., Bonzano, A., Chiesa, A., Cavaliere, R., Capra, A., Anselmino, M., Quattrocchio, G., Scaroma, F., and Moiraghi, P.

32. An unusual myxoid leiomyosarcoma of the heart

Author

Angela Pucci, Gagliardotto, P., Papandrea, C., Di Rosa, E., Morello, M., Di Summa, M., and Mollo, F.

Subjects
Leiomyosarcoma, Heart Ventricles, Nuclear Proteins, Middle Aged, Neoplasm Proteins, Heart Neoplasms, Fatal Outcome, Ki-67 Antigen, Antigens, Neoplasm, Heart Septum, Mitotic Index, Humans, Female, Neoplasm Recurrence, Local
Abstract

We report a case of myxoid leiomyosarcoma originating from the interventricular septum in the outflow tract of the right ventricle. Although the gross features suggested a benign myxoma, histologic examination demonstrated features of a smooth muscle tumor, which was characterized by low mitotic index and a bland degree of atypia with few cells immunoreactive for cell cycle-associated Ki-67 antigen. The tumor relapsed twice, and the patient (a 61-year-old woman) died 18 months after the first diagnosis. This case demonstrates that myxoid leiomyomatous proliferations of the heart must be considered potentially malignant, even when the gross features and degree of cellular atypia seem to suggest otherwise.

33. New trends in the epidemiological and clinical features of infective endocarditis: Results of a multicenter prospective study

Author

Cecchi, E., Forno, D., Imazio, M., Migliardi, A., Roberto Gnavi, Dal Conte, I., Trinchero, R., Patrone, M., Ricchiardi, E., Ambrogio, V., Aloi, N., Madama, G., Ugliengo, G., Leonardi, G., Sturlese, U., Perotti, L., Riva, L., Subrizi, M., Tassani, G., Dalmasso, M., Ravera, A., D Arrigo, A., Parrini, I., Giacosa, M., Gioria, A., Petronio, M., Angelino, P., Conte, M. R., Avonto, L., Pecchio, F., Baralis, G., Tidu, M., Chinaglia, A., Pomari, F., Demichelis, B., Demarie, D., Ghisio, A., Moratti, M., Coda, L., Di Perri, G., Lucchini, A. M., Lipani, F., Veglio, V., Preziosi, C., Soranzo, M. L., Biancochinto, F., Mangiardi, L., Morello, M., Calachanis, M., Bernasconi, C., Checco, L., Emanuelli, G., Peano, P., Pagano, G. F., Schinco, P., Bonino, G., Di Summa, M., Forsennati, P. G., Actisdato, G., Pasquino, M., Santoro, M., Cavallo Perin, P., Crosazzo, C., Bonzano, A., Chiesa, A., Cavaliere, R., Capra, A., Anselmino, M., Quattrocchio, G., Scaroina, F., and Moiraghi, P.

35. Pathologic changes in a long-term heterotopic heart transplant survivor

Author

Angela Pucci, Passarino G, Marra S, Papandrea C, Casaccia M, di Summa M, and Mollo F

Subjects
Heart Failure, Male, Fatal Outcome, Transplantation, Heterotopic, Proliferating Cell Nuclear Antigen, Cyclosporine, Graft Occlusion, Vascular, Heart Transplantation, Humans, Coronary Disease, Middle Aged
Abstract

This report concerns the pathologic findings observed at autopsy in a 10-year-old heterotopic heart transplant under cyclosporine treatment. The allograft showed a diffuse multivessel atherosclerotic disease whereas in the recipient heart coronary arteries and aorta were focally affected by atherosclerosis. The proliferating cell nuclear antigen had significantly increased expression in the allograft vessels in comparison with the recipient.

42. Vision-based omnidirectional indoor robots for autonomous navigation and localization in manufacturing industry.

Author

Patruno C, Renò V, Nitti M, Mosca N, di Summa M, and Stella E

Abstract

In this paper, we present a new generation of omnidirectional automated guided vehicles (omniagv) used for transporting materials within a manufacturing factory with the ability to navigate autonomously and intelligently by interacting with the environment, including people and other entities. This robot has to be integrated into the operating environment without significant changes to the current facilities or heavy redefinitions of the logistics processes already running. For this purpose, different vision-based systems and advanced methods in mobile and cognitive robotics are developed and integrated. In this context, vision and perception are key factors. Different developed modules are in charge of supporting the robot during its navigation in the environment. Specifically, the localization module provides information about the robot pose by using visual odometry and wheel odometry systems. The obstacle avoidance module can detect obstacles and recognize some object classes for adaptive navigation. Finally, the tag detection module aids the robot during the picking phase of carts and provides information for global localization. The smart integration of vision and perception is paramount for effectively using the robot in the industrial context. Extensive qualitative and quantitative results prove the capability and effectiveness of the proposed AGV to navigate in the considered industrial environment., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Ettore Stella reports financial support was provided by Puglia Region., (© 2024 The Authors.)

Published
2024
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43. Label-Free Intracellular Multi-Specificity in Yeast Cells by Phase-Contrast Tomographic Flow Cytometry.

Author

Bianco V, D'Agostino M, Pirone D, Giugliano G, Mosca N, Di Summa M, Scerra G, Memmolo P, Miccio L, Russo T, Stella E, and Ferraro P

Subjects
Flow Cytometry methods, Cytoplasm, Microscopy, Fluorescence, Saccharomyces cerevisiae, Artificial Intelligence
Abstract

In-flow phase-contrast tomography provides a 3D refractive index of label-free cells in cytometry systems. Its major limitation, as with any quantitative phase imaging approach, is the lack of specificity compared to fluorescence microscopy, thus restraining its huge potentialities in single-cell analysis and diagnostics. Remarkable results in introducing specificity are obtained through artificial intelligence (AI), but only for adherent cells. However, accessing the 3D fluorescence ground truth and obtaining accurate voxel-level co-registration of image pairs for AI training is not viable for high-throughput cytometry. The recent statistical inference approach is a significant step forward for label-free specificity but remains limited to cells' nuclei. Here, a generalized computational strategy based on a self-consistent statistical inference to achieve intracellular multi-specificity is shown. Various subcellular compartments (i.e., nuclei, cytoplasmic vacuoles, the peri-vacuolar membrane area, cytoplasm, vacuole-nucleus contact site) can be identified and characterized quantitatively at different phases of the cells life cycle by using yeast cells as a biological model. Moreover, for the first time, virtual reality is introduced for handling the information content of multi-specificity in single cells. Full fruition is proofed for exploring and interacting with 3D quantitative biophysical parameters of the identified compartments on demand, thus opening the route to a metaverse for 3D microscopy., (© 2023 The Authors. Small Methods published by Wiley-VCH GmbH.)

Published
2023
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44. Fast track extubation in paediatric cardiothoracic surgery in developing countries.

Author

Iezzi F, Di Summa M, Sarto PD, and Munene J

Subjects
Adolescent, Child, Child, Preschool, Cohort Studies, Developing Countries, Female, Humans, Infant, Intubation, Intratracheal methods, Male, Medical Missions, Patient Selection, Postoperative Complications epidemiology, Time Factors, Airway Extubation methods, Anesthetics administration & dosage, Cardiac Surgical Procedures methods, Heart Defects, Congenital surgery
Abstract

In recent years, low-dose, short-acting anesthetic agents, which replaced the former high-dose opioid regimens, offer a faster postoperative recovery and decrease the need for mechanical ventilatory support. In this study, the aim was to determine the success rate of fast-track approach in surgical procedures for congenital heart disease. There is some evidence, mostly from retrospective analyses, that fast tracking can be beneficial. Ninety-one cases with moderate complex cardiac malformations were operated with fast-track protocol during cardiothoracic charitable missions. The essential aspects of early extubation in our cohort included: selected patients with good preoperative status, good surgical result with hemodynamic stability in low dose of inotropic drugs at the end of bypass, no active bleeding. In this setting a carefull choice and dosing of anesthetic agents, alongside a good postoperative analgesia are mandatory. The authors found that an early extubation (< 4 hours) can be both effective and safe as it reduces intubation and ventilator times without increasing post-operative complications in pediatric congenital heart disease. This study supports a wider use of fast-track extubation protocols in paediatric patients submitted for congenital cardiac surgery in developing countries., Competing Interests: The authors declare no competing interest.

Published
2019
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45. Huge left ventricular pseudoaneurysm rupture in an African young adult patient.

Author

di Summa M, Iezzi F, Oburu G, and Mehta N

Subjects
Adult, Aneurysm, False diagnosis, Aneurysm, False ethnology, Aneurysm, Ruptured diagnosis, Aneurysm, Ruptured ethnology, Female, Heart Aneurysm diagnosis, Heart Aneurysm ethnology, Humans, Kenya, Treatment Outcome, Aneurysm, False surgery, Aneurysm, Ruptured surgery, Black People, Cardiac Surgical Procedures, Heart Aneurysm surgery
Abstract

A pseudoaneurysm of the ventricle is formed when there is rupture of the myocardial wall with the discontinuity being roofed over by the pericardium and mural thrombus or fibrous tissue without myocardial elements. Cardiac pseudoaneurysm is a rare and a potentially life-threatening event. Early prophylactic surgical aneurysmectomy has been the treatment of choice. In this context, we report an unusual case of giant left ventricular pseudoaneurysm, as a result of unknown aetiology, appearing like a pulsatile mass, which was easily seen from the chest wall, in a young female, successfully treated with surgery., (© The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)

Published
2014
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46. Surgical management of giant fibroelastoma of the aortic valve with repair through valve sparing technique.

Author

Di Summa M and Iezzi F

Abstract

Background: Fibroelastomas account for less than 10% of all cardiac tumors, representing the most common valvular and the second most common cardiac benign tumor, following myxomas.Fibroelastomas are histologically benign, but they can result in life-threatening complications such as stroke, acute valvular dysfunction, embolism, ventricular fibrillation, and sudden death., Methods: A valve-sparing technique with simple shave excision of the tumor was undertaken with success., Results: Surgical resection should be offered to all patients who have symptoms and to asymptomatic patients who have pedunculated lesions or tumors larger than 1 cm in diameter. Valve-sparing excision produces good long-term results in most instances., Conclusion: We report our surgical experience of a giant fibroelastoma in the aortic valve.< Learning objective: Medical and surgical management of giant fibroelastoma of aortic valve.>.

Published
2014
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47. Aorta-to-right ventricular outflow tract fistula with coronary cusp prolapse.

Author

Tiwari KK, Salvati AC, di Summa M, Barbieri A, Portella G, and Strada G

Subjects
Aorta diagnostic imaging, Aortic Diseases diagnosis, Aortic Diseases surgery, Aortic Valve Prolapse diagnosis, Aortic Valve Prolapse surgery, Cardiopulmonary Bypass, Echocardiography, Doppler, Color, Echocardiography, Transesophageal, Fistula diagnosis, Fistula surgery, Heart Defects, Congenital diagnosis, Heart Defects, Congenital surgery, Heart Failure etiology, Heart Valve Prosthesis Implantation, Heart Ventricles diagnostic imaging, Humans, Male, Sternotomy, Treatment Outcome, Young Adult, Aorta abnormalities, Aortic Diseases complications, Aortic Valve Prolapse etiology, Fistula complications, Heart Defects, Congenital complications, Heart Ventricles abnormalities
Abstract

We describe a rare case of aorta-to-right ventricular fistula in a 20-year-old man who presented with signs and symptoms of congestive heart failure. He was successfully treated by closing the fistula with a Dacron patch from the aortic side. At follow-up, he was asymptomatic with no left-to-right shunt.

Published
2013
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48. Giant fibroelastoma of the aortic valve.

Author

di Summa M and Iezzi F

Abstract

Fibroelastomas account for less than 10% of all cardiac tumours, representing the most common valvular and the second most common cardiac benign tumour, following myxomas. Fibroelastomas are histologically benign; they can result in life-threatening complications such as stroke, acute valvular dysfunction, embolism, ventricular fibrillation, and sudden death. Surgical resection should be offered to all patients who have symptoms and to asymptomatic patients who have pedunculated lesions or tumors larger than 1 cm in diameter. Valve-sparing excision produces good long-term results in most instances. We report our surgical experience of a giant fibroelastoma in the aortic valve.

Published
2013
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