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4. Considerations When Using Gabapentinoids to Treat Trigeminal Neuralgia: A Review

Author

De Stefano G, Di Pietro G, Truini A, Cruccu G, and Di Stefano G

Subjects
gabapentin, pregabalin, trigeminal neuralgia., Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Gianfranco De Stefano,* Giuseppe Di Pietro,* Andrea Truini, Giorgio Cruccu, Giulia Di Stefano Department of Human Neuroscience, Sapienza University, Rome, Italy*These authors contributed equally to this workCorrespondence: Giulia Di Stefano, Department of Human Neuroscience, Sapienza University, Rome, Viale Università 30, Rome, 00185, Italy, Tel +39 06 49694209, Email giulia.distefano@uniroma1.itAbstract: Despite the exemplary efficacy of voltage-gated sodium channel blockers as a first-line treatment of trigeminal neuralgia, the pharmacological management of this excruciating facial pain condition remains a major issue, as these first-line drugs produce intolerable side effects in a significant portion of patients. In addition, in patients with concomitant continuous pain, the efficacy of these drugs may drop, thus suggesting the opportunity to test the efficacy of different drug categories. The aim of this review is to provide current, evidence-based, knowledge about the use of gabapentin and other α 2δ ligands in patients with trigeminal neuralgia. We searched for relevant papers within PubMed, EMBASE, the Cochrane Database of Systematic Reviews and the Clinical Trials database (ClinicalTrials.gov), considering publications up to April 2023. Two authors independently selected studies for inclusion and data extraction. The efficacy of α 2δ ligands, gabapentin and pregabalin, has been assessed in seven controlled or open-label studies. Despite the low quality of evidence, the favorable tolerability profile and the possible action on concomitant continuous pain make this drug category of interest for future trials in trigeminal neuralgia.Plain Language Summary: Trigeminal neuralgia is a really excruciating neuropathic pain condition. Although sodium channel blockers are efficacious in most of the patients, the poor tolerability profile and the limited efficacy in patients with concomitant continuous pain represent a major issue over the long-term treatment.Gabapentin and other α 2δ ligands, which have been shown to be effective in the treatment of other neuropathic conditions characterized by continuous pain, may be tried as additional agents along with sodium channel blockers.In this review, based on a systematic search of relevant literature, we aim to provide current, evidence-based, knowledge about the use of gabapentin and other α 2δ ligands in patients with trigeminal neuralgia. The favourable tolerability profile and the possible action on concomitant continuous pain make this drug category of interest for future trials in trigeminal neuralgia.Keywords: gabapentin, pregabalin, trigeminal neuralgia

Published
2023

8. Douleur neuropathique associée à la Covid-19 : revue systématique et méta-analyse *.

Author

Di Stefano, G., Falco, P., Galosi, E., Di Pietro, G., Leone, C., and Truini, A.

Subjects
*COVID-19, *NEURALGIA, *SCIENTIFIC literature, *DISEASE complications, *PUBLICATION bias
Abstract

Background and Objective: Neuropathic pain is an occasionally reported complication of coronavirus disease 2019 (Covid-19) that has received increased attention in scientific literature. In this systematic review and meta-analysis, we aimed to provide information on the frequency of neuropathic pain associated with Covid-19. Databases and Data Treatment: We systematically reviewed and analysed literature regarding neuropathic pain associated with Covid-19. Literature searches were conducted in PubMed, EMBASE and Cochrane Library databases. We considered prospective and retrospective studies published up until September 2022 (limitations included English language, full-text publications and studies including at least 10 patients). A random effects meta-analysis was performed and heterogeneity and publication bias were assessed. Results: We identified 149 studies. We included 17 studies in the systematic review, and six studies reporting the frequency of neuropathic pain in the acute/subacute phase of Covid-19 in the meta-analysis. The estimated frequency of neuropathic pain ranged between 0.4 and 25%. Forest plot analysis showed that the random effect overall frequency was 10% (95% confidence interval: 5%–15%), with a high level of heterogeneity (Chi2 = 104; Tau2 = 0.004; df = 5; I2 = 95%; test for overall effect: Z = 3.584; p < 0.0005). The overall risk of bias was moderate in all studies selected, particularly due to the poor description of neuropathic pain diagnostic criteria. Conclusions: The pooled estimated frequency of neuropathic pain associated with Covid-19 should be considered with caution due to the high heterogeneity across studies and the poor description of the neuropathic pain diagnostic criteria applied. Significance : Emerging evidence supports the development of neuropathic pain as a complication of Covid-19. However, longitudinal studies enrolling consecutive patients with Covid-19 that detail the diagnostic criteria for neuropathic pain are needed to better assess the frequency of this condition. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Properties of Galactic cirrus clouds observed by BOOMERanG

Author

Veneziani, M., Ade, P. A. R., Bock, J. J., Boscaleri, A., Crill, B. P., de Bernardis, P., De Gasperis, G., de Oliveira-Costa, A., De Troia, G., Di Stefano, G., Ganga, K. M., Jones, W. C., Kisner, T. S., Lange, A. E., MacTavish, C. J., Masi, S., Mauskopf, P. D., Montroy, T. E., Natoli, P., Netterfield, C. B., Pascale, E., Piacentini, F., Pietrobon, D., Polenta, G., Ricciardi, S., Romeo, G., and Ruhl, J. E.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The physical properties of galactic cirrus emission are not well characterized. BOOMERanG is a balloon-borne experiment designed to study the cosmic microwave background at high angular resolution in the millimeter range. The BOOMERanG 245 and 345GHz channels are sensitive to interstellar signals, in a spectral range intermediate between FIR and microwave frequencies. We look for physical characteristics of cirrus structures in a region at high galactic latitudes (b~-40{\deg}) where BOOMERanG performed its deepest integration, combining the BOOMERanG data with other available datasets at different wavelengths. We have detected eight emission patches in the 345 GHz map, consistent with cirrus dust in the Infrared Astronomical Satellite maps. The analysis technique we have developed allows to identify the location and the shape of cirrus clouds, and to extract the flux from observations with different instruments at different wavelengths and angular resolutions. We study the integrated flux emitted from these cirrus clouds using data from Infrared Astronomical Satellite (IRAS), DIRBE, BOOMERanG and Wilkinson Microwave Anisotropy Probe (WMAP) in the frequency range 23-3000 GHz (13 mm 100 micron wavelength). We fit the measured spectral energy distributions with a combination of a grey body and a power-law spectra considering two models for the thermal emission. The temperature of the thermal dust component varies in the 7 - 20 K range and its emissivity spectral index is in the 1 - 5 range. We identified a physical relation between temperature and spectral index as had been proposed in previous works. This technique can be proficiently used for the forthcoming Planck and Herschel missions data., Comment: accepted for publication in The Astrophysical Journal

Published
2009
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11. BOOMERanG Constraints on Primordial Non-Gaussianity from Analytical Minkowski Functionals

Author

Natoli, P., De Troia, G., Hikage, C., Komatsu, E., Migliaccio, M., Ade, P. A. R., Bock, J. J., Bond, J. R., Borrill, J., Boscaleri, A., Contaldi, C. R., Crill, B. P., de Bernardis, P., de Gasperis, G., de Oliveira-Costa, A., Di Stefano, G., Hivon, E., Kisner, T. S., Jones, W. C., Lange, A. E., Masi, S., Mauskopf, P. D., MacTavish, C. J., Melchiorri, A., Montroy, T. E., Netterfield, C. B., Pascale, E., Piacentini, F., Polenta, G., Ricciardi, S., Romeo, G., Ruhl, J. E., Tegmark, M., Veneziani, M., and Vittorio, N.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We use Minkowski Functionals (MF) to constrain a primordial non-Gaussian contribution to the CMB intensity field as observed in the 150 GHz and 145 GHz BOOMERanG maps from the 1998 and 2003 flights, respectively, performing for the first time a joint analysis of the two datasets. A perturbative expansion of the MF formulae in the limit of a weakly non-Gaussian field yields analytical formulae, derived by Hikage et al. (2006), which can be used to constrain the coupling parameter f_NL without the need for non-Gaussian simulations. We find -1020

Published
2009
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12. Subdegree Sunyaev-Zel'dovich Signal from Multifrequency BOOMERanG observations

Author

Veneziani, M., Amblard, A., Cooray, A., Piacentini, F., Pietrobon, D., Serra, P., Ade, P. A. R., Bock, J. J., Bond, J. R., Borrill, J., Boscaleri, A., Cabella, P., Contaldi, C. R., Crill, B. P., de Bernardis, P., De Gasperis, G., de Oliveira-Costa, A., De Troia, G., Di Stefano, G., Ganga, K. M., Hivon, E., Jones, W. C., Kisner, T. S., Lange, A. E., MacTavish, C. J., Masi, S., Mauskopf, P. D., Melchiorri, A., Montroy, T. E., Natoli, P., Netterfield, C. B., Pascale, E., Polenta, G., Ricciardi, S., Romeo, G., Ruhl, J. E., Santini, P., Tegmark, M., and Vittorio, N.

Subjects
Astrophysics - Cosmology and Extragalactic Astrophysics
Abstract

The Sunyaev-Zel'dovich (SZ) effect is the inverse Compton-scattering of cosmic microwave background (CMB) photons by hot electrons in the intervening gas throughout the universe. The effect has a distinct spectral signature that allows its separation from other signals in multifrequency CMB datasets. Using CMB anisotropies measured at three frequencies by the BOOMERanG 2003 flight we constrain SZ fluctuations in the 10 arcmin to 1 deg angular range. Propagating errors and potential systematic effects through simulations, we obtain an overall upper limit of 15.3 uK (2 sigma) for rms SZ fluctuations in a broad bin between multipoles of of 250 and 1200 at the Rayleigh-Jeans (RJ) end of the spectrum. When combined with other CMB anisotropy and SZ measurements, we find that the local universe normalization of the density perturbations is sigma-8(SZ) < 0.96 at the 95% confidence level, consistent with sigma-8 determined from primordial perturbations., Comment: accepted for publication in ApJ. Letters

Published
2009
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13. Acetyl-L-carnitine in painful peripheral neuropathy: a systematic review

Author

Di Stefano G, Di Lionardo A, Galosi E, Truini A, and Cruccu G

Subjects
neuropathic pain, treatment, neuroprotective function, epigenetic mechanism, Medicine (General), R5-920
Abstract

Giulia Di Stefano, Andrea Di Lionardo, Eleonora Galosi, Andrea Truini, Giorgio CruccuDepartment of Human Neuroscience, Sapienza University, Rome, ItalyAbstract: Acetyl-L-carnitine (ALC) has shown a neuroprotective effect in patients with peripheral neuropathies of different etiologies. Preclinical studies demonstrated a central anti-nociceptive action, both in neuropathic and nociceptive pain models. The present review aims to provide the knowledge on the efficacy of ALC in patients with painful peripheral neuropathy, based on the evidence. Consistent with the PRISMA statement, authors searched PubMed, Embase and the Cochrane Database of Systematic Reviews for relevant papers, including those issued before April 2018. Two authors independently selected studies for inclusion and data extraction: only trials including patients with a diagnosis of peripheral neuropathy and involving at least 10 patients were considered for the purposes of this review. Fourteen clinical trials were revised, to provide the level of evidence for neuropathy. To assess the global efficacy of ALC in painful peripheral neuropathy, a meta-analysis of four randomized controlled trials was performed. Mean difference in pain reduction as measured on a 10-cm VAS, and 95% CIs were used for pooling continuous data from each trial. Four randomized controlled trials tested ALC in patients with neuropathy secondary to diabetes and to antiretroviral therapy for HIV. Compared to placebo, ALC produced a significant pain reduction equal to 20.2% (95% CI: 8.3%-32.1%, P

Published
2019

14. Searching for non Gaussian signals in the BOOMERanG 2003 CMB maps

Author

De Troia, G., Ade, P. A. R., Bock, J. J., Bond, J. R., Borrill, J., Boscaleri, A., Cabella, P., Contaldi, C. R., Crill, B. P., de Bernardis, P., De Gasperis, G., de Oliveira-Costa, A., Di Stefano, G., Ferreira, P. G., Hivon, E., Jaffe, A. H., Kisner, T. S., Kunz, M., Jones, W. C., Lange, A. E., Liguori, M., Masi, S., Matarrese, S., Mauskopf, P. D., MacTavish, C. J., Melchiorri, A., Montroy, T. E., Natoli, P., Netterfield, C. B., Pascale, E., Piacentini, F., Pogosyan, D., Polenta, G., Prunet, S., Ricciardi, S., Romeo, G., Ruhl, J. E., Santini, P., Tegmark, M., Veneziani, M., and Vittorio, N.

Subjects
Astrophysics
Abstract

We analyze the BOOMERanG 2003 (B03) 145 GHz temperature map to constrain the amplitude of a non Gaussian, primordial contribution to CMB fluctuations. We perform a pixel space analysis restricted to a portion of the map chosen in view of high sensitivity, very low foreground contamination and tight control of systematic effects. We set up an estimator based on the three Minkowski functionals which relies on high quality simulated data, including non Gaussian CMB maps. We find good agreement with the Gaussian hypothesis and derive the first limits based on BOOMERanG data for the non linear coupling parameter f_NL as -300

Published
2007
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15. A measurement of the polarization-temperature angular cross power spectrum of the Cosmic Microwave Background from the 2003 flight of BOOMERANG

Author

Piacentini, F, Ade, P, Bock, J, Bond, J, Borrill, J, Boscaleri, A, Cabella, P, Contaldi, C, Crill, B, de Bernardis, P, De Gasperis, G, de Oliveira-Costa, A, De Troia, G, Di Stefano, G, Hivon, E, Jaffe, A, Kisner, T, Jones, W, Lange, A, Masi, S, Mauskopf, P, MacTavish, C, Melchiorri, A, Montroy, T, Natoli, P, Netterfield, C, Pascale, E, Pogosyan, D, Polenta, G, Prunet, S, Ricciardi, S, Romeo, G, Ruhl, J, Santini, P, Tegmark, M, Veneziani, M, and Vittorio, N

Subjects
Astrophysics
Abstract

We present a measurement of the temperature-polarization angular cross power spectrum, , of the Cosmic Microwave Background. The result is based on $\sim 200$ hours of data from 8 polarization sensitive bolometers operating at 145 GHz during the 2003 flight of BOOMERANG. We detect a significant correlation in the $\ell$-range between 50 and 950 with a statistical significance > 3.5 sigma. Contamination by polarized foreground emission and systematic effects are negligible in comparison with statistical uncertainty. The spectrum is consistent with previous detections and with the "concordance model" that assumes adiabatic initial conditions. This is the first measurement of using bolometric detectors., Comment: Submitted to Ap.J.; Version with high resolution figures will be available at: http://oberon.roma1.infn.it/boomerang/b2k and http://cmb.phys.cwru.edu/boomerang/

Published
2005
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16. A Measurement of the Angular Power Spectrum of the CMB Temperature Anisotropy from the 2003 Flight of Boomerang

Author

Jones, W. C., Ade, P, Bock, J, Bond, J, Borrill, J, Boscaleri, A, Cabella, P, Contaldi, C, Crill, B, de Bernardis, P, De Gasperis, G, de Oliveira-Costa, A, De Troia, G, Di Stefano, G, Hivon, E, Jaffe, A, Kisner, T, Lange, A, MacTavish, C, Masi, S, Mauskopf, P, Melchiorri, A, Montroy, T, Natoli, P, Netterfield, B, Pascale, E, Piacentini, F, Pogosyan, D, Polenta, G, Prunet, S, Ricciardi, S, Romeo, G, Ruhl, J, Santini, P, Tegmark, M, Veneziani, M, and Vittorio, N

Subjects
Astrophysics
Abstract

We report on observations of the Cosmic Microwave Background (CMB) obtained during the January 2003 flight of Boomerang . These results are derived from 195 hours of observation with four 145 GHz Polarization Sensitive Bolometer (PSB) pairs, identical in design to the four 143 GHz Planck HFI polarized pixels. The data include 75 hours of observations distributed over 1.84% of the sky with an additional 120 hours concentrated on the central portion of the field, itself representing 0.22% of the full sky. From these data we derive an estimate of the angular power spectrum of temperature fluctuations of the CMB in 24 bands over the multipole range (50 < l < 1500). A series of features, consistent with those expected from acoustic oscillations in the primordial photon-baryon fluid, are clearly evident in the power spectrum, as is the exponential damping of power on scales smaller than the photon mean free path at the epoch of last scattering (l > 900). As a consistency check, the collaboration has performed two fully independent analyses of the time ordered data, which are found to be in excellent agreement., Comment: 11 pages, 7 figures, 3 tables. High resolution figures and data are available at http://cmb.phys.cwru.edu/boomerang/ and http://oberon.roma1.infn.it/boomerang/b2k

Published
2005
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17. Cosmological Parameters from the 2003 flight of BOOMERANG

Author

MacTavish, C. J., Ade, P. A. R., Bock, J. J., Bond, J. R., Borrill, J., Boscaleri, A., Cabella, P., Contaldi, C. R., Crill, B. P., de Bernardis, P., De Gasperis, G., de Oliveira-Costa, A., De Troia, G., Di Stefano, G., Hivon, E., Jaffe, A. H., Jones, W. C., Kisner, T. S., Lange, A. E., Lewis, A. M., Masi, S., Mauskopf, P. D., Melchiorri, A., Montroy, T. E., Natoli, P., Netterfield, C. B., Pascale, E., Piacentini, F., Pogosyan, D., Polenta, G., Prunet, S., Ricciardi, S., Romeo, G., Ruhl, J. E., Santini, P., Tegmark, M., Veneziani, M., and Vittorio, N.

Subjects
Astrophysics, High Energy Physics - Phenomenology
Abstract

We present the cosmological parameters from the CMB intensity and polarization power spectra of the 2003 Antarctic flight of the BOOMERANG telescope. The BOOMERANG data alone constrains the parameters of the $\Lambda$CDM model remarkably well and is consistent with constraints from a multi-experiment combined CMB data set. We add LSS data from the 2dF and SDSS redshift surveys to the combined CMB data set and test several extensions to the standard model including: running of the spectral index, curvature, tensor modes, the effect of massive neutrinos, and an effective equation of state for dark energy. We also include an analysis of constraints to a model which allows a CDM isocurvature admixture., Comment: 18 pages, 10 figures, submitted to ApJ

Published
2005
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18. A Measurement of the CMB <EE> Spectrum from the 2003 Flight of BOOMERANG

Author

Montroy, T. E., Ade, P. A. R., Bock, J. J., Bond, J. R., Borrill, J., Boscaleri, A., Cabella, P., Contaldi, C. R., Crill, B. P., de Bernardis, P., De Gasperis, G., de Oliveira-Costa, A., De Troia, G., di Stefano, G., Hivon, E., Jaffe, A. H., Kisner, T. S., Jones, W. C., Lange, A. E., Masi, S., Mauskopf, P. D., MacTavish, C. J., Melchiorri, A., Natoli, P., Netterfield, C. B., Pascale, E., Piacentini, F., Pogosyan, D., Polenta, G., Prunet, S., Ricciardi, S., Romeo, G., Ruhl, J. E., Santini, P., Tegmark, M., Veneziani, M., and Vittorio, N.

Subjects
Astrophysics
Abstract

We report measurements of the CMB polarization power spectra from the January 2003 Antarctic flight of BOOMERANG. The primary results come from six days of observation of a patch covering 0.22% of the sky centered near R.A. = 82.5 deg., Dec= -45 deg. The observations were made using four pairs of polarization sensitive bolometers operating in bands centered at 145 GHz. Using two independent analysis pipelines, we measure a non-zero signal in the range 100< l <1000 with a significance 4.8-sigma, a 2-sigma upper limit of 8.6 uK^2 for any contribution, and a 2-sigma upper limit of 7.0 uK^2 for the spectrum. Estimates of foreground intensity fluctuations and the non-detection of and signals rule out any significant contribution from galactic foregrounds. The results are consistent with a Lambda-CDM cosmology seeded by adiabatic perturbations. We note that this is the first detection of CMB polarization with bolometric detectors., Comment: Submitted to Astrophysical Journal

Published
2005
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19. Instrument, Method, Brightness and Polarization Maps from the 2003 flight of BOOMERanG

Author

Masi, S, Ade, P, Bock, J, Bond, J, Borrill, J, Boscaleri, A, Cabella, P, Contaldi, C, Crill, B, de Bernardis, P, De Gasperis, G, de Oliveira-Costa, A, De Troia, G, Di Stefano, G, Ehlers, P, Hivon, E, Hristov, V, Iacoangeli, A, Jaffe, A, Jones, W, Kisner, T, Lange, A, MacTavish, C, Marini-Bettolo, C, Mason, P, Mauskopf, P, Montroy, T, Nati, F, Nati, L, Natoli, P, Netterfield, C, Pascale, E, Piacentini, F, Pogosyan, D, Polenta, G, Prunet, S, Ricciardi, S, Romeo, G, Ruhl, J, Santini, P, Tegmark, M, Torbet, E, Veneziani, M, and Vittorio, N

Subjects
Astrophysics
Abstract

We present the BOOMERanG-03 experiment and maps of the Stokes parameters I, Q, U of the microwave sky obtained during a 14 day balloon flight in 2003. Three regions of the southern sky were surveyed: a deep survey (~ 90 square degrees) and a shallow survey (~ 750 square degrees) at high Galactic latitudes (both centered at RA ~ 5.5 h, dec ~ -45 deg) and a survey of ~ 300 square degrees across the Galactic plane at RA ~ 9.1 h, dec ~ -47 deg. All three surveys were carried out in three wide frequency bands centered at 145, 245 and 345 GHz, with an angular resolution of ~ 10'. The 145 GHz maps of Stokes I are dominated by Cosmic Microwave Background (CMB) temperature anisotropy, which is mapped with high signal to noise ratio. The measured anisotropy pattern is consistent with the pattern measured in the same region by BOOMERanG-98 and by WMAP. The 145 GHz maps of Stokes Q and U provide a robust statistical detection of polarization of the CMB when subjected to a power spectrum analysis. This amplitude of the polarization is consistent with that of the CMB in the $\Lambda$CDM cosmological scenario. At 145 GHz, in the CMB surveys, the intensity and polarization of the astrophysical foregrounds are found to be negligible with respect to the cosmological signal. At 245 and 345 GHz we detect ISD emission correlated to the 3000 GHz IRAS/DIRBE maps, and give upper limits for any other non-CMB component. We also present intensity maps of the surveyed section of the Galactic plane. These are compared to monitors of different interstellar components, showing that a variety of emission mechanisms is present in that region., Comment: see http://oberon.roma1.infn.it/boomerang/b2k and http://cmb.phys.cwru.edu/boomerang/ for a high resolution version

Published
2005
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22. Measuring CMB Polarization with BOOMERANG

Author

Montroy, T., Ade, P. A. R., Balbi, A., Bock, J. J., Bond, J. R., Borrill, J., Boscaleri, A., Cabella, P., Contaldi, C. R., Crill, B. P., de Bernardis, P., De Gasperis, G., de Oliveira-Costa, A., De Troia, G., di Stefano, G., Ganga, K., Hivon, E., Hristov, V. V., Iacoangeli, A., Jaffe, A. H., Kisner, T. S., Jones, W. C., Lange, A. E., Masi, S., Mauskopf, P. D., MacTavish, C., Melchiorri, A., Nati, F., Natoli, P., Netterfield, C. B., Pascale, E., Piacentini, F., Pogosyan, D., Polenta, G., Prunet, S., Ricciardi, S., Romeo, G., Ruhl, J. E., Torbet, E., Tegmark, M., and Vittorio, N.

Subjects
Astrophysics
Abstract

BOOMERANG is a balloon-borne telescope designed for long duration (LDB) flights around Antarctica. The second LDB Flight of BOOMERANG took place in January 2003. The primary goal of this flight was to measure the polarization of the CMB. The receiver uses polarization sensitive bolometers at 145 GHz. Polarizing grids provide polarization sensitivity at 245 and 345 GHz. We describe the BOOMERANG telescope noting changes made for 2003 LDB flight, and discuss some of the issues involved in the measurement of polarization with bolometers. Lastly, we report on the 2003 flight and provide an estimate of the expected results., Comment: 12 pages, 8 figures, To be published in the proceedings of "The Cosmic Microwave Background and its Polarization", New Astronomy Reviews, (eds. S. Hanany and K.A. Olive). Fixed typos, and reformatted citations

Published
2003
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24. The Ginger project – preliminary results

Author

Altucci, C., Bajardi, F., Basti, A., Beverini, N., Capozziello, S., Carelli, G., Ciampini, D., De Luca, G., Devoti, R., Di Stefano, G., Di Virgilio, A. D. V., Fuso, F., Giacomelli, U., Govoni, A., Maccioni, E., Marsili, P., Ortolan, A., Porzio, A., Simonelli, A., Terreni, G., Velotta, R., Altucci, C., Bajardi, F., Basti, A., Beverini, N., Capozziello, S., Carelli, G., Ciampini, D., De Luca, G., Devoti, R., Di Stefano, G., Di Virgilio, A. D. V., Fuso, F., Giacomelli, U., Govoni, A., Maccioni, E., Marsili, P., Ortolan, A., Porzio, A., Simonelli, A., Terreni, G., and Velotta, R.

Published
2023
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25. Measuring CMB polarization with Boomerang

Author

Montroy, T, Ade, PAR, Balbi, A, Bock, JJ, Bond, JR, Borrill, J, Boscaleri, A, Cabella, P, Contaldi, CR, Crill, BP, de Bernardis, P, De Gasperis, G, de Oliveira-Costa, A, De Troia, G, di Stefano, G, Ganga, K, Hivon, E, Hristov, VV, Iacoangeli, A, Jaffe, AH, Kisner, TS, Jones, WC, Lange, AE, Masi, S, Mauskopf, PD, MacTavish, C, Melchiorri, A, Nati, F, Natoli, P, Netterfield, CB, Pascale, E, Piacentini, F, Pogosyan, D, Polenta, G, Prunet, S, Ricciardi, S, Romeo, G, Ruhl, JE, Torbet, E, Tegmark, M, and Vittorio, N

Subjects
astro-ph, Astronomical and Space Sciences, Astronomy & Astrophysics
Abstract

Boomerang is a balloon-borne telescope designed for long duration (LDB) flights around Antarctica. The second LDB flight of Boomerang took place in January 2003. The primary goal of this flight was to measure the polarization of the CMB. The receiver uses polarization sensitive bolometers at 145 GHz. Polarizing grids provide polarization sensitivity at 245 and 345 GHz. We describe the Boomerang telescope noting changes made for 2003 LDB flight, and discuss some of the issues involved in the measurement of polarization with bolometers. Lastly, we report on the 2003 flight and provide an estimate of the expected results. © 2003 Elsevier B.V. All rights reserved.

Published
2003

27. Ictal blinking, an under-recognized phenomenon: our experience and literature review

Author

Saporito MAN, Vitaliti G, Pavone P, Di Stefano G, Striano P, Caraballo RH, and Falsaperla R

Subjects
ictal blinking, focal motor phenomenon, ictal electroencephalographic pattern, occipital area, infancy., Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Marco Andrea Nicola Saporito,1 Giovanna Vitaliti,2 Piero Pavone,2 Giuseppa Di Stefano,1 Pasquale Striano,3 Roberto Horacio Caraballo,4 Raffaele Falsaperla2 1Neonatal Intensive Care Unit, Santo Bambino Hospital, Policlinico-Vittorio Emanuele University Hospital, University of Catania, Catania, Italy; 2Paediatric Operative Unit and Acute and Emergency, Policlinico-Vittorio Emanuele University Hospital, University of Catania, Catania, Italy; 3Pediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, Institute “G. Gaslini” University of Genova, Genoa, Italy; 4Department of Neurology, Hospital de Pediatría “Prof Dr Juan P Garrahan”, Buenos Aires, Argentina Abstract: Ictal blinking (IB) is a very rare disease manifesting as an epileptic motor event in children and adults. Until now it has not been included in any classification of focal seizures of the International League Against Epilepsy Commission. It could be unilateral or bilateral, isolated or in association with other motor manifestations such as limbs’ clonus and spasms. Its pathogenesis has not been clearly established: paroxysmal discharges from different areas of the brain could cause IB by activation of trigeminal fibers. Herein authors report three infants and a child with IB, observed in three pediatric centers in two different countries. We also performed a review of literature data, suggesting IB as a seizure type to be included in international classifications, and describing the specific electroencephalographic pattern of this condition. Keywords: ictal blinking, focal motor phenomenon, ictal electroencephalographic pattern, occipital area, infancy

Published
2017

28. Erratum to “How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex” [Clin. Neurophysiol. 132 (2021) 2989–2995]

Author

Leone, C., primary, Di Lionardo, A., additional, Di Pietro, G., additional, Di Stefano, G., additional, Falco, P., additional, Blockeel, A.J., additional, Caspani, O., additional, Garcia-Larrea, L., additional, Mouraux, A., additional, Phillips, K.G., additional, Treede, R.D., additional, and Truini, A., additional

Published
2023
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31. BURKITT LYMPHOMA AND HIGH-GRADE B-CELL LYMPHPHOMA WITH 11q ABBERRATIONS SHARE A TRANSCRIPTIONAL PROFILE RESEMBLING A SUBPOPULATION OF EARLY DARK ZONE CELLS

Author

Di Stefano, G., primary, Chteinberg, E., additional, Loeffler-Wirth, H., additional, Hillebrecht, S., additional, Wagener, R., additional, Abramov, D., additional, Burkhardt, B., additional, Louissant, A., additional, Horn, H., additional, Mottok, A., additional, Oschlies, I., additional, Klapper, W., additional, Schafernak, K., additional, Zhang, Y., additional, Del-Val, C., additional, Rosenwald, A., additional, Binder, H., additional, Ott, G., additional, Leoncini, L., additional, and Siebert, Reiner, additional

Published
2022
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32. EPSTEIN-BARR VIRUS ORCHESTRATE THE TUMOR MICROENVIRONMENT OF BURKITT LYMPHOMA

Author

Siciliano, M., primary, Tornambè, S., additional, Del Corvo, M., additional, Granai, M., additional, Mundo, L., additional, Sapienza, M., additional, Arcuri, F., additional, Mancini, V., additional, Santi, R., additional, Di Stefano, G., additional, Marafioti, T., additional, Ott, G., additional, Siebert, R., additional, Fend, L. Quintanilla, additional, Fend, F., additional, Pileri, S., additional, Leoncini, L., additional, and Lazzi, S., additional

Published
2022
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38. Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

Author

Collier, D. A., Ferreira, I. A. T. M., Kotagiri, P., Datir, R. P., Lim, E. Y., Touizer, E., Meng, B., Abdullahi, A., Baker, S., Dougan, G., Hess, C., Kingston, N., Lehner, P. J., Lyons, P. A., Matheson, N. J., Owehand, W. H., Saunders, C., Summers, C., Thaventhiran, J. E. D., Toshner, M., Weekes, M. P., Maxwell, P., Shaw, A., Bucke, A., Calder, J., Canna, L., Domingo, J., Elmer, A., Fuller, S., Harris, J., Hewitt, S., Kennet, J., Jose, S., Kourampa, J., Meadows, A., O'Brien, C., Price, J., Publico, C., Rastall, R., Ribeiro, C., Rowlands, J., Ruffolo, V., Tordesillas, H., Bullman, B., Dunmore, B. J., Fawke, S., Graf, S., Hodgson, J., Huang, C., Hunter, K., Jones, E., Legchenko, E., Matara, C., Martin, J., Mescia, F., O'Donnell, C., Pointon, L., Pond, N., Shih, J., Sutcliffe, R., Tilly, T., Treacy, C., Tong, Z., Wood, J., Wylot, M., Bergamaschi, L., Betancourt, A., Bower, G., Cossetti, C., De Sa, A., Epping, M., Gleadall, N., Grenfell, R., Hinch, A., Huhn, O., Jackson, S., Jarvis, I., Krishna, B., Lewis, D., Marsden, J., Nice, F., Okecha, G., Omarjee, O., Perera, M., Potts, M., Richoz, N., Romashova, V., Yarkoni, N. S., Sharma, R., Stefanucci, L., Stephens, J., Strezlecki, M., Turner, L., D. D. De Bie E. M., Bunclark, K., Josipovic, M., Mackay, M., Michael, A., Rossi, S., Selvan, M., Spencer, S., Yong, C., Ansaripour, A., Mwaura, L., Patterson, C., Polwarth, G., Polgarova, P., di Stefano, G., Fahey, C., Michel, R., Bong, S. -H., Coudert, J. D., Holmes, E., Allison, J., Butcher, H., Caputo, D., Clapham-Riley, D., Dewhurst, E., Furlong, A., Graves, B., Gray, J., Ivers, T., Kasanicki, M., Le Gresley, E., Linger, R., Meloy, S., Muldoon, F., Ovington, N., Papadia, S., Phelan, I., Stark, H., Stirrups, K. E., Townsend, P., Walker, N., Webster, J., Smith, K. G. C., Bradley, J. R., Ceron-Gutierrez, L., Cortes-Acevedo, P., Barcenas-Morales, G., Linterman, M. A., Mccoy, L. E., Davis, C., Thomson, E., Mckinney, E., Doffinger, R., Wills, M., Gupta, R. K., Collier, Dami A [0000-0001-5446-4423], Datir, Rawlings P [0000-0003-0521-2144], Smith, Kenneth GC [0000-0003-3829-4326], Linterman, Michelle A [0000-0001-6047-1996], McCoy, Laura E [0000-0001-9503-7946], Thomson, Emma [0000-0003-1482-0889], Lyons, Paul A [0000-0001-7035-8997], Gupta, Ravindra K [0000-0001-9751-1808], and Apollo - University of Cambridge Repository

Subjects
Male, 0301 basic medicine, Aging, Secondary, T-Lymphocytes, Antibodies, Viral, Neutralization, 0302 clinical medicine, 80 and over, Medicine, Viral, Neutralizing, Adult, Aged, Aged, 80 and over, Antibodies, Neutralizing, Autoantibodies, B-Lymphocytes, BNT162 Vaccine, COVID-19 Vaccines, Female, Health Personnel, Humans, Immunization, Secondary, Immunoglobulin A, Immunoglobulin Class Switching, Immunoglobulin G, Immunologic Memory, Inflammation, Interferon-gamma, Interleukin-2, Middle Aged, SARS-CoV-2, Somatic Hypermutation, Immunoglobulin, Spike Glycoprotein, Coronavirus, Vaccination, Vaccines, Synthetic, Immunity, Sars-Cov-2, Vaccines, education.field_of_study, Multidisciplinary, biology, Spike Glycoprotein, 030220 oncology & carcinogenesis, Antibody, Population, Article, Antibodies, 03 medical and health sciences, Immune system, Immunoglobulin, education, business.industry, Synthetic, Somatic Hypermutation, Vaccine efficacy, Coronavirus, 030104 developmental biology, Immunization, Immunology, biology.protein, business
Abstract

Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, there is little information about vaccine efficacy against variants of concern (VOC) in individuals above eighty years of age1. Here we analysed immune responses following vaccination with the BNT162b2 mRNA vaccine2 in elderly participants and younger healthcare workers. Serum neutralization and levels of binding IgG or IgA after the first vaccine dose were lower in older individuals, with a marked drop in participants over eighty years old. Sera from participants above eighty showed lower neutralization potency against the B.1.1.7 (Alpha), B.1.351 (Beta) and P.1. (Gamma) VOC than against the wild-type virus and were more likely to lack any neutralization against VOC following the first dose. However, following the second dose, neutralization against VOC was detectable regardless of age. The frequency of SARS-CoV-2 spike-specific memory B cells was higher in elderly responders (whose serum showed neutralization activity) than in non-responders after the first dose. Elderly participants showed a clear reduction in somatic hypermutation of class-switched cells. The production of interferon-γ and interleukin-2 by SARS-CoV-2 spike-specific T cells was lower in older participants, and both cytokines were secreted primarily by CD4 T cells. We conclude that the elderly are a high-risk population and that specific measures to boost vaccine responses in this population are warranted, particularly where variants of concern are circulating., Nature, 596 (7872), ISSN:0028-0836, ISSN:1476-4687

Published
2021
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39. Lactate Upregulates the Expression of DNA Repair Genes, Causing Intrinsic Resistance of Cancer Cells to Cisplatin

Author

Govoni M., Rossi V., Di Stefano G., Manerba M., Govoni M., Rossi V., Di Stefano G., and Manerba M.

Subjects
lactate, Cancer Research, DNA Repair, cisplatin, Antineoplastic Agents, Pathology and Oncology Archive, General Medicine, Brief Research Report, glycolysis, Up-Regulation, Pathology and Forensic Medicine, Gene Expression Regulation, Neoplastic, glycolysi, Oncology, Drug Resistance, Neoplasm, Cell Line, Tumor, Neoplasms, Humans, DNA damage, Lactic Acid
Abstract

Intrinsic or acquired drug resistance is one of the major problems compromising the success of antineoplastic treatments. Several evidences correlated some therapeutic failures with changes in cell metabolic asset and in line with these findings, hindering the glycolytic metabolism of cancer cells via lactate dehydrogenase (LDH) inhibition was found to overcome the resistance to chemotherapeutic agents. Lactate, the product of LDH reaction, was shown to be involved in epigenetic regulation of gene expression. The experiments described in this paper were aimed at highlighting a possible direct effect of lactate in modifying the response of cancer cells to a chemotherapeutic treatment. To discriminate between the effects potentially caused by glycolytic metabolism from those directly referable to lactate, we selected cancer cell lines able to grow in glucose deprived conditions and evaluated the impact of lactate on the cellular response to cisplatin-induced DNA damage. In lactate-exposed cells we observed a reduced efficacy of cisplatin, which was associated with reduced signatures of DNA damage, enhanced DNA recombination competence and increased expression of a panel of genes involved in DNA repair. The identified genes take part in mismatch and nucleotide excision repair pathways, which were found to contribute in restoring the cisplatin-induced DNA damage. The obtained results suggest that this metabolite could play a role in reducing the efficacy of antineoplastic treatments.

Published
2021
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41. SARS-CoV-2 evolution during treatment of chronic infection

Author

Kemp, S. A., Collier, D. A., Datir, R. P., Ferreira, I. A. T. M., Gayed, S., Jahun, A., Hosmillo, M., Rees-Spear, C., Mlcochova, P., Lumb, I. U., Roberts, D. J., Chandra, A., Temperton, N., Baker, S., Dougan, G., Hess, C., Kingston, N., Lehner, P. J., Lyons, P. A., Matheson, N. J., Owehand, W. H., Saunders, C., Summers, C., Thaventhiran, J. E. D., Toshner, M., Weekes, M. P., Bucke, A., Calder, J., Canna, L., Domingo, J., Elmer, A., Fuller, S., Harris, J., Hewitt, S., Kennet, J., Jose, S., Kourampa, J., Meadows, A., O'Brien, C., Price, J., Publico, C., Rastall, R., Ribeiro, C., Rowlands, J., Ruffolo, V., Tordesillas, H., Bullman, B., Dunmore, B. J., Fawke, S., Graf, S., Hodgson, J., Huang, C., Hunter, K., Jones, E., Legchenko, E., Matara, C., Martin, J., Mescia, F., O'Donnell, C., Pointon, L., Pond, N., Shih, J., Sutcliffe, R., Tilly, T., Treacy, C., Tong, Z., Wood, J., Wylot, M., Bergamaschi, L., Betancourt, A., Bower, G., Cossetti, C., De Sa, A., Epping, M., Gleadall, N., Grenfell, R., Hinch, A., Huhn, O., Jackson, S., Jarvis, I., Lewis, D., Marsden, J., Nice, F., Okecha, G., Omarjee, O., Perera, M., Richoz, N., Romashova, V., Yarkoni, N. S., Sharma, R., Stefanucci, L., Stephens, J., Strezlecki, M., Turner, L., De Bie, E. M. D. D., Bunclark, K., Josipovic, M., Mackay, M., Rossi, S., Selvan, M., Spencer, S., Yong, C., Ansaripour, A., Michael, A., Mwaura, L., Patterson, C., Polwarth, G., Polgarova, P., di Stefano, G., Fahey, C., Michel, R., Bong, S. -H., Coudert, J. D., Holmes, E., Allison, J., Butcher, H., Caputo, D., Clapham-Riley, D., Dewhurst, E., Furlong, A., Graves, B., Gray, J., Ivers, T., Kasanicki, M., Le Gresley, E., Linger, R., Meloy, S., Muldoon, F., Ovington, N., Papadia, S., Phelan, I., Stark, H., Stirrups, K. E., Townsend, P., Walker, N., Webster, J., Robson, S. C., Loman, N. J., Connor, T. R., Golubchik, T., Martinez Nunez, R. T., Ludden, C., Corden, S., Johnston, I., Bonsall, D., Smith, C. P., Awan, A. R., Bucca, G., Estee Torok, M., Saeed, K., Prieto, J. A., Jackson, D. K., Hamilton, W. L., Snell, L. B., Moore, C., Harrison, E. M., Goncalves, S., Fairley, D. J., Loose, M. W., Watkins, J., Livett, R., Moses, S., Amato, R., Nicholls, S., Bull, M., Smith, D. L., Barrett, J., Aanensen, D. M., Curran, M. D., Parmar, S., Aggarwal, D., Shepherd, J. G., Parker, M. D., Glaysher, S., Bashton, M., Underwood, A. P., Pacchiarini, N., Loveson, K. F., Carabelli, A. M., Templeton, K. E., Langford, C. F., Sillitoe, J., de Silva, T. I., Wang, D., Kwiatkowski, D., Rambaut, A., O'Grady, J., Cottrell, S., Holden, M. T. G., Thomson, E. C., Osman, H., Andersson, M., Chauhan, A. J., Hassan-Ibrahim, M. O., Lawniczak, M., Alderton, A., Chand, M., Constantinidou, C., Unnikrishnan, M., Darby, A. C., Hiscox, J. A., Paterson, S., Martincorena, I., Robertson, D. L., Volz, E. M., Page, A. J., Pybus, O. G., Bassett, A. R., Ariani, C. V., Spencer Chapman, M. H., K. K., Li, Shah, R. N., Jesudason, N. G., Taha, Y., Mchugh, M. P., Dewar, R., Jahun, A. S., Mcmurray, C., Pandey, S., Mckenna, J. P., Nelson, A., Young, G. R., Mccann, C. M., Elliott, S., Lowe, H., Temperton, B., Roy, S., Price, A., Rey, S., Wyles, M., Rooke, S., Shaaban, S., de Cesare, M., Letchford, L., Silveira, S., Pelosi, E., Wilson-Davies, E., O'Toole, A., Hesketh, A. R., Stark, R., du Plessis, L., Ruis, C., Adams, H., Bourgeois, Y., Michell, S. L., Gramatopoulos, D., Edgeworth, J., Breuer, J., Todd, J. A., Fraser, C., Buck, D., John, M., Kay, G. L., Palmer, S., Peacock, S. J., Heyburn, D., Weldon, D., Robinson, E., Mcnally, A., Muir, P., Vipond, I. B., Boyes, J., Sivaprakasam, V., Salluja, T., Dervisevic, S., Meader, E. J., Park, N. R., Oliver, K., Jeffries, A. R., Ott, S., da Silva Filipe, A., Simpson, D. A., Williams, C., Masoli, J. A. H., Knight, B. A., Jones, C. R., Koshy, C., Ash, A., Casey, A., Bosworth, A., Ratcliffe, L., Xu-McCrae, L., Pymont, H. M., Hutchings, S., Berry, L., Jones, K., Halstead, F., Davis, T., Holmes, C., Iturriza-Gomara, M., Lucaci, A. O., Randell, P. A., Cox, A., Madona, P., Harris, K. A., Brown, J. R., Mahungu, T. W., Irish-Tavares, D., Haque, T., Hart, J., Witele, E., Fenton, M. L., Liggett, S., Graham, C., Swindells, E., Collins, J., Eltringham, G., Campbell, S., Mcclure, P. C., Clark, G., Sloan, T. J., Jones, C., Lynch, J., Warne, B., Leonard, S., Durham, J., Williams, T., Haldenby, S. T., Storey, N., Alikhan, N. -F., Holmes, N., Carlile, M., Perry, M., Craine, N., Lyons, R. A., Beckett, A. H., Goudarzi, S., Fearn, C., Cook, K., Dent, H., Paul, H., Davies, R., Blane, B., Girgis, S. T., Beale, M. A., Bellis, K. L., Dorman, M. J., Drury, E., Kane, L., Kay, S., Mcguigan, S., Nelson, R., Prestwood, L., Rajatileka, S., Batra, R., Williams, R. J., Kristiansen, M., Green, A., Justice, A., Mahanama, A. I. K., Samaraweera, B., Hadjirin, N. F., Quick, J., Poplawski, R., Kermack, L. M., Reynolds, N., Hall, G., Chaudhry, Y., Pinckert, M. L., Georgana, I., Moll, R. J., Thornton, A., Myers, R., Stockton, J., Williams, C. A., Yew, W. C., Trotter, A. J., Trebes, A., MacIntyre-Cockett, G., Birchley, A., Adams, A., Plimmer, A., Gatica-Wilcox, B., Mckerr, C., Hilvers, E., Jones, H., Asad, H., Coombes, J., Evans, J. M., Fina, L., Gilbert, L., Graham, L., Cronin, M., Kumziene-Summerhayes, S., Taylor, S., Jones, S., Groves, D. C., Zhang, P., Gallis, M., Louka, S. F., Starinskij, I., Jackson, C., Gourtovaia, M., Tonkin-Hill, G., Lewis, K., Tovar-Corona, J. M., James, K., Baxter, L., Alam, M. T., Orton, R. J., Hughes, J., Vattipally, S., Ragonnet-Cronin, M., Nascimento, F. F., Jorgensen, D., Boyd, O., Geidelberg, L., Zarebski, A. E., Raghwani, J., Kraemer, M. U. G., Southgate, J., Lindsey, B. B., Freeman, T. M., Keatley, J. -P., Singer, J. B., de Oliveira Martins, L., Yeats, C. A., Abudahab, K., Taylor, B. E. W., Menegazzo, M., Danesh, J., Hogsden, W., Eldirdiri, S., Kenyon, A., Mason, J., Robinson, T. I., Holmes, A., Hartley, J. A., Curran, T., Mather, A. E., Shankar, G., Jones, R., Howe, R., Morgan, S., Wastenge, E., Chapman, M. R., Mookerjee, S., Stanley, R., Smith, W., Peto, T., Eyre, D., Crook, D., Vernet, G., Kitchen, C., Gulliver, H., Merrick, I., Guest, M., Munn, R., Bradley, D. T., Wyatt, T., Beaver, C., Foulser, L., Churcher, C. M., Brooks, E., Smith, K. S., Galai, K., Mcmanus, G. M., Bolt, F., Coll, F., Meadows, L., Attwood, S. W., Davies, A., De Lacy, E., Downing, F., Edwards, S., Scarlett, G. P., Jeremiah, S., Smith, N., Leek, D., Sridhar, S., Forrest, S., Cormie, C., Gill, H. K., Dias, J., Higginson, E. E., Maes, M., Young, J., Wantoch, M., Jamrozy, D., Lo, S., Patel, M., Hill, V., Bewshea, C. M., Ellard, S., Auckland, C., Harrison, I., Bishop, C., Chalker, V., Richter, A., Beggs, A., Best, A., Percival, B., Mirza, J., Megram, O., Mayhew, M., Crawford, L., Ashcroft, F., Moles-Garcia, E., Cumley, N., Hopes, R., Asamaphan, P., Niebel, M. O., Gunson, R. N., Bradley, A., Maclean, A., Mollett, G., Blacow, R., Bird, P., Helmer, T., Fallon, K., Tang, J., Hale, A. D., Macfarlane-Smith, L. R., Harper, K. L., Carden, H., Machin, N. W., Jackson, K. A., Ahmad, S. S. Y., George, R. P., Turtle, L., O'Toole, E., Watts, J., Breen, C., Cowell, A., Alcolea-Medina, A., Charalampous, T., Patel, A., Levett, L. J., Heaney, J., Rowan, A., Taylor, G. P., Shah, D., Atkinson, L., Lee, J. C. D., Westhorpe, A. P., Jannoo, R., Lowe, H. L., Karamani, A., Ensell, L., Chatterton, W., Pusok, M., Dadrah, A., Symmonds, A., Sluga, G., Molnar, Z., Baker, P., Bonner, S., Essex, S., Barton, E., Padgett, D., Scott, G., Greenaway, J., Payne, B. A. I., Burton-Fanning, S., Waugh, S., Raviprakash, V., Sheriff, N., Blakey, V., Williams, L. -A., Moore, J., Stonehouse, S., Smith, L., Davidson, R. K., Bedford, L., Coupland, L., Wright, V., Chappell, J. G., Tsoleridis, T., Ball, J., Khakh, M., Fleming, V. M., Lister, M. M., Howson-Wells, H. C., Boswell, T., Joseph, A., Willingham, I., Duckworth, N., Walsh, S., Wise, E., Moore, N., Mori, M., Cortes, N., Kidd, S., Williams, R., Gifford, L., Bicknell, K., Wyllie, S., Lloyd, A., Impey, R., Malone, C. S., Cogger, B. J., Levene, N., Monaghan, L., Keeley, A. J., Partridge, D. G., Raza, M., Evans, C., Johnson, K., Abnizova, I., Aigrain, L., Ali, M., Allen, L., Anderson, R., Ariani, C., Austin-Guest, S., Bala, S., Bassett, A., Battleday, K., Beal, J., Beale, M., Bellany, S., Bellerby, T., Bellis, K., Berger, D., Berriman, M., Betteridge, E., Bevan, P., Binley, S., Bishop, J., Blackburn, K., Bonfield, J., Boughton, N., Bowker, S., Brendler-Spaeth, T., Bronner, I., Brooklyn, T., Buddenborg, S. K., Bush, R., Caetano, C., Cagan, A., Carter, N., Cartwright, J., Monteiro, T. C., Chapman, L., Chillingworth, T. -J., Clapham, P., Clark, R., Clarke, A., Clarke, C., Cole, D., Cook, E., Coppola, M., Cornell, L., Cornwell, C., Corton, C., Crackett, A., Cranage, A., Craven, H., Craw, S., Crawford, M., Cutts, T., Dabrowska, M., Davies, M., Dawson, J., Day, C., Densem, A., Dibling, T., Dockree, C., Dodd, D., Dogga, S., Dougherty, M., Dove, A., Drummond, L., Dudek, M., Durrant, L., Easthope, E., Eckert, S., Ellis, P., Farr, B., Fenton, M., Ferrero, M., Flack, N., Fordham, H., Forsythe, G., Francis, M., Fraser, A., Freeman, A., Galvin, A., Garcia-Casado, M., Gedny, A., Girgis, S., Glover, J., Goodwin, S., Gould, O., Gray, A., Gray, E., Griffiths, C., Gu, Y., Guerin, F., Hamilton, W., Hanks, H., Harrison, E., Harrott, A., Harry, E., Harvison, J., Heath, P., Hernandez-Koutoucheva, A., Hobbs, R., Holland, D., Holmes, S., Hornett, G., Hough, N., Huckle, L., Hughes-Hallet, L., Hunter, A., Inglis, S., Iqbal, S., Jackson, A., Jackson, D., Verdejo, C. J., Jones, M., Kallepally, K., Kay, K., Keatley, J., Keith, A., King, A., Kitchin, L., Kleanthous, M., Klimekova, M., Korlevic, P., Krasheninnkova, K., Lane, G., Langford, C., Laverack, A., Law, K., Lensing, S., Lewis-Wade, A., Liddle, J., Lin, Q., Lindsay, S., Linsdell, S., Long, R., Lovell, J., Mack, J., Maddison, M., Makunin, A., Mamun, I., Mansfield, J., Marriott, N., Martin, M., Mayho, M., Mccarthy, S., Mcclintock, J., Mchugh, S., Mcminn, L., Meadows, C., Mobley, E., Moll, R., Morra, M., Morrow, L., Murie, K., Nash, S., Nathwani, C., Naydenova, P., Neaverson, A., Nerou, E., Nicholson, J., Nimz, T., Noell, G. G., O'Meara, S., Ohan, V., Olney, C., Ormond, D., Oszlanczi, A., Pang, Y. F., Pardubska, B., Park, N., Parmar, A., Patel, G., Payne, M., Peacock, S., Petersen, A., Plowman, D., Preston, T., Puethe, C., Quail, M., Rajan, D., Rance, R., Rawlings, S., Redshaw, N., Reynolds, J., Reynolds, M., Rice, S., Richardson, M., Roberts, C., Robinson, K., Robinson, M., Robinson, D., Rogers, H., Rojo, E. M., Roopra, D., Rose, M., Rudd, L., Sadri, R., Salmon, N., Saul, D., Schwach, F., Scott, C., Seekings, P., Shirley, L., Simms, A., Sinnott, M., Sivadasan, S., Siwek, B., Sizer, D., Skeldon, K., Skelton, J., Slater-Tunstill, J., Sloper, L., Smerdon, N., Smith, C., Smith, J., Smith, K., Smith, M., Smith, S., Smith, T., Sneade, L., Soria, C. D., Sousa, C., Souster, E., Sparkes, A., Spencer-Chapman, M., Squares, J., Steed, C., Stickland, T., Still, I., Stratton, M., Strickland, M., Swann, A., Swiatkowska, A., Sycamore, N., Swift, E., Symons, E., Szluha, S., Taluy, E., Tao, N., Taylor, K., Thompson, S., Thompson, M., Thomson, M., Thomson, N., Thurston, S., Toombs, D., Topping, B., Tovar-Corona, J., Ungureanu, D., Uphill, J., Urbanova, J., Jansen Van, P., Vancollie, V., Voak, P., Walker, D., Walker, M., Waller, M., Ward, G., Weatherhogg, C., Webb, N., Wells, A., Wells, E., Westwood, L., Whipp, T., Whiteley, T., Whitton, G., Whitwham, A., Widaa, S., Williams, M., Wilson, M., Wright, S., Farr, B. W., Quail, M. A., Thurston, S. A. J., Bronner, I. F., Redshaw, N. M., Lensing, S. V., Balcazar, C. E., Gallagher, M. D., Williamson, K. A., Stanton, T. D., Michelsen, M. L., Warwick-Dugdale, J., Manley, R., Farbos, A., Harrison, J. W., Sambles, C. M., Studholme, D. J., Lackenby, A., Mbisa, T., Platt, S., Miah, S., Bibby, D., Manso, C., Hubb, J., Dabrera, G., Ramsay, M., Bradshaw, D., Schaefer, U., Groves, N., Gallagher, E., Lee, D., Williams, D., Ellaby, N., Hartman, H., Manesis, N., Patel, V., Ledesma, J., Twohig, K. A., Allara, E., Pearson, C., Cheng, J. K. J., Bridgewater, H. E., Frost, L. R., Taylor-Joyce, G., Brown, P. E., Tong, L., Broos, A., Mair, D., Nichols, J., Carmichael, S. N., Smollett, K. L., Nomikou, K., Aranday-Cortes, E., Johnson, N., Nickbakhsh, S., Vamos, E. E., Hughes, M., Rainbow, L., Eccles, R., Nelson, C., Whitehead, M., Gregory, R., Gemmell, M., Wierzbicki, C., Webster, H. J., Fisher, C. L., Signell, A. W., Betancor, G., Wilson, H. D., Nebbia, G., Flaviani, F., Cerda, A. C., Merrill, T. V., Wilson, R. E., Cotic, M., Bayzid, N., Thompson, T., Acheson, E., Rushton, S., O'Brien, S., Baker, D. J., Rudder, S., Aydin, A., Sang, F., Debebe, J., Francois, S., Vasylyeva, T. I., Zamudio, M. E., Gutierrez, B., Marchbank, A., Maksimovic, J., Spellman, K., Mccluggage, K., Morgan, M., Beer, R., Afifi, S., Workman, T., Fuller, W., Bresner, C., Angyal, A., Green, L. R., Parsons, P. J., Tucker, R. M., Brown, R., Whiteley, M., Rowe, W., Siveroni, I., Le-Viet, T., Gaskin, A., Johnson, R., Sharrocks, K., Blane, E., Modis, Y., Leigh, K. E., Briggs, J. A. G., van Gils, M. J., Smith, K. G. C., Bradley, J. R., Doffinger, R., Ceron-Gutierrez, L., Barcenas-Morales, G., Pollock, D. D., Goldstein, R. A., Smielewska, A., Skittrall, J. P., Gouliouris, T., Goodfellow, I. G., Gkrania-Klotsas, E., Illingworth, C. J. R., Mccoy, L. E., Gupta, R. K., Medical Microbiology and Infection Prevention, AII - Infectious diseases, Collier, Dami A [0000-0001-5446-4423], Jahun, Aminu [0000-0002-4585-1701], Temperton, Nigel [0000-0002-7978-3815], Modis, Yorgo [0000-0002-6084-0429], Briggs, John AG [0000-0003-3990-6910], Goldstein, Richard A [0000-0001-5148-4672], Skittrall, Jordan P [0000-0002-8228-3758], Gkrania-Klotsas, Effrossyni [0000-0002-0930-8330], McCoy, Laura E [0000-0001-9503-7946], Gupta, Ravindra K [0000-0001-9751-1808], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Male, Time Factors, viruses, Passive, Antibodies, Viral, CITIID-NIHR BioResource COVID-19 Collaboration, 2.1 Biological and endogenous factors, Viral, Aetiology, Neutralizing, Lung, Phylogeny, neutralising antibodies, Infectivity, education.field_of_study, Genome, Multidisciplinary, Alanine, biology, High-Throughput Nucleotide Sequencing, Viral Load, Spike Glycoprotein, Virus Shedding, Adenosine Monophosphate, Aged, Antibodies, Neutralizing, COVID-19, Chronic Disease, Genome, Viral, Humans, Immune Evasion, Immune Tolerance, Immunization, Passive, Immunosuppression Therapy, Mutagenesis, Mutant Proteins, Mutation, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Evolution, Molecular, Infectious Diseases, Pneumonia & Influenza, Antibody, Infection, Viral load, Biotechnology, Evolution, General Science & Technology, antibody escape, Convalescent plasma, 030106 microbiology, Population, evasion, Antibodies, Virus, Article, Vaccine Related, resistance, 03 medical and health sciences, Immune system, COVID-19 Genomics UK (COG-UK) Consortium, Biodefense, Genetics, Viral shedding, education, COVID-19 Serotherapy, QR355, Prevention, Wild type, Molecular, Pneumonia, Virology, COVID-19 Drug Treatment, Coronavirus, Emerging Infectious Diseases, Good Health and Well Being, 030104 developmental biology, biology.protein, Immunization, immune suppression, mutation
Abstract

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for virus infection through the engagement of the human ACE2 protein1 and is a major antibody target. Here we show that chronic infection with SARS-CoV-2 leads to viral evolution and reduced sensitivity to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma, by generating whole-genome ultra-deep sequences for 23 time points that span 101 days and using in vitro techniques to characterize the mutations revealed by sequencing. There was little change in the overall structure of the viral population after two courses of remdesivir during the first 57 days. However, after convalescent plasma therapy, we observed large, dynamic shifts in the viral population, with the emergence of a dominant viral strain that contained a substitution (D796H) in the S2 subunit and a deletion (ΔH69/ΔV70) in the S1 N-terminal domain of the spike protein. As passively transferred serum antibodies diminished, viruses with the escape genotype were reduced in frequency, before returning during a final, unsuccessful course of convalescent plasma treatment. In vitro, the spike double mutant bearing both ΔH69/ΔV70 and D796H conferred modestly decreased sensitivity to convalescent plasma, while maintaining infectivity levels that were similar to the wild-type virus.The spike substitution mutant D796H appeared to be the main contributor to the decreased susceptibility to neutralizing antibodies, but this mutation resulted in an infectivity defect. The spike deletion mutant ΔH69/ΔV70 had a twofold higher level of infectivity than wild-type SARS-CoV-2, possibly compensating for the reduced infectivity of the D796H mutation. These data reveal strong selection on SARS-CoV-2 during convalescent plasma therapy, which is associated with the emergence of viral variants that show evidence of reduced susceptibility to neutralizing antibodies in immunosuppressed individuals.

Published
2021

42. Correction to: To detach or not to detach? The role of psychological detachment on the relationship between heavy work investment and well-being: A latent profile analysis (Current Psychology, (2021), 10.1007/s12144-021-01958-3)

Author

Gaudiino M., Di Stefano G., Gaudiino M., and Di Stefano G.

Subjects
Workaholism, Settore M-PSI/06 - Psicologia Del Lavoro E Delle Organizzazioni, Well-being at work, Psychological detachment, Work Engagement, Latent Profile Analysis
Abstract

The original version of this article unfortunately contained a mistake. The article title should be “To detach or not to detach? The role of psychological detachment on the relationship between heavy work investment and well-being: A latent profile analysis”. The original article has been corrected.

Published
2021

43. Hydrokinetic pancreatic function and insulin secretion are moduled by Cl⁻ uniporter Slc26a9 in mice

Author

Li, T. (T.), di Stefano, G. (G.), Raza, G. S. (G. S.), Sommerer, I. (I.), Riederer, B. (B.), Römermann, D. (D.), Tan, X. (X.), Tan, Q. (Q.), Pallagi, P. (P.), Hollenbach, M. (M.), Herzig, K.-H. (K.-H.), Seidler, U. (U.), Li, T. (T.), di Stefano, G. (G.), Raza, G. S. (G. S.), Sommerer, I. (I.), Riederer, B. (B.), Römermann, D. (D.), Tan, X. (X.), Tan, Q. (Q.), Pallagi, P. (P.), Hollenbach, M. (M.), Herzig, K.-H. (K.-H.), and Seidler, U. (U.)

Abstract

Aim: Slc26a9 is a member of the Slc26 multifunctional anion transporter family. Polymorphisms in Slc26a9 are associated with an increased incidence of meconium ileus and diabetes in cystic fibrosis patients. We investigated the expression of Slc26a9 in the murine pancreatic ducts, islets and parenchyma, and elucidated its role in pancreatic ductal electrolyte and fluid secretion and endocrine function. Methods: Pancreatic Slc26a9 and CFTR mRNA expression, fluid and bicarbonate secretion were assessed in slc26a9−/− mice and their age- and sex-matched wild-type (wt) littermates. Glucose and insulin tolerance tests were performed. Results: Compared with stomach, the mRNA expression of Slc26a9 was low in pancreatic parenchyma, 20-fold higher in microdissected pancreatic ducts than parenchyma, and very low in islets. CFTR mRNA was ~10 fold higher than Slc26a9 mRNA expression in each pancreatic cell type. Significantly reduced pancreatic fluid secretory rates and impaired glucose tolerance were observed in female slc26a9−/− mice, whereas alterations in male mice did not reach statistical significance. No significant difference was observed in peripheral insulin resistance in slc26a9−/− compared to sex- and aged-matched wt controls. In contrast, isolated slc26a9−/− islets in short term culture displayed no difference in insulin content, but a significantly reduced glucose-stimulated insulin secretion compared to age- and sex-matched wt islets, suggesting that the impaired glucose tolerance in the absence of Slc26a9 expression these is a pancreatic defect. Conclusions: Deletion of Slc26a9 is associated with a reduction in pancreatic fluid secretion and impaired glucose tolerance in female mice. The results underline the importance of Slc26a9 in pancreatic physiology.

Published
2022

47. A preliminary experience with a new intramedullary nail for trochanteric fractures

Author

Maniscalco, P., Quattrini, F., Ciatti, C., Burgio, V., Rivera, F., Di Stefano, G., and Pavone, V.

Subjects
Aged, 80 and over, Male, Hip Fractures, Intramedullary nail, COVID-19, Bone Nails, Silicon coating, Fracture Fixation, Intramedullary, D-Nail, Pertrochaneric fractures, Humans, Original Article, Female, Aged
Abstract

Background and aim of the work: The worldwide incidence of fractures of the proximal end of the femur is increasing as the average age of the population rises. The current surgical gold treatment standard is intramedullary nail fixation. The Authors present their experience with the D-Nail system for intertrochanteric femur fractures. Methods: From January 1st to February 21st 2020 (breakout of COVID-19 pandemic) 34 patients were treated with the D-Nail system: 11 with basicervical fractures, 16 with intertrochanteric stable fractures and 7 with intertrochanteric unstable fractures. In 11 cases, a single cephalic screw was used; in 23 cases, two of them were used. Distal locking was executed in 7 patients. Follow-up time ranged from 2 to 3 months. Results: None of the reported intra- or post-operative complication was linked to the fixation device or the surgical technique. Patients were monitored with clinical and radiological checkups using modified Harris Hip Score to accurately evaluate the fluctuations in the rehabilitation period. Conclusion: The main advantages of this synthesis device are the proximal hole’s peculiar shape, which allows the possibility to position one or two cephalic screws on the same nail, and the silicon coating, which provides numerous biological advantages. Distal locking was executed in selected cases only, based on fracture type. Optimum treatment involves rapid execution of surgery, minimal trauma during surgery, maximum mechanical stability, and rapid weight-bearing. Although our case number is small and follow-up time brief, our results are encouraging. (www.actabiomedica.it)

Published
2020

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