14 results on '"Di Segni F"'
Search Results
2. Percutaneous elastic fixation of proximal humeral fractures: operative indications, techniques, results and complications
- Author
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Rosa, M. A., Maccauro, G., Nizegorodcew, T., Falcone, G., and Di Segni, F.
- Published
- 2002
- Full Text
- View/download PDF
3. Did the effect of placebo increase in rcts of panic disorder across the years?
- Author
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Di Segni, F., Zoppi, T., Forcina, F., Anibaldi, G., Bargagna, P., Telesforo, C. L., Montebovi, F., Callovini, G., Giuseppin, G., Janiri, D., Molinaro, M., Sani, G., and Kotzalidis, G. D.
- Subjects
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PANIC disorders , *PLACEBOS , *PANIC attacks , *OBSESSIVE-compulsive disorder , *DATABASE searching , *CATATONIA - Abstract
Introduction: The curious effect of an increase of the placebo effect across year of publication has been shown for depression, schizophrenia, obsessive-compulsive disorder, as well as for some medical conditions like hypertension and pain. Objectives: We aimed to observe how randomised clinical trials with a placebo control behave at this respect in panic disorder trials. Methods: We searched the PubMed database using the strategy: (panic disorder OR panic attack disorder) AND placebo, which on 3 November 2020 produced 779 records. Inclusion criteria were the above stated, excluded were all studies focusing on the same patients as others and those not providing intelligible data. In our selection we used the PRISMA statement and reached agreement with Delphi rounds. Results: We identified through other sources further 3 studies. The finally eligible studies were 82, excluded were 700 studies, mainly consisting of reviews (176), challenge studies (173), not dealing with panic disorder (67), studies with unsuitable designs to detect placebo effect (53), studies using same populations as others (36), those with misfocused outcomes (57), those lumping diagnoses and not allowing to separate data for panic disorder (22), and those not using placebo at all (21). Mean response to placebo in included panic disorder studies was 36.01±19.812, ranging from 0 to 76.19%; the correlation with year of publication was positive and significant (Pearson's r= 0.246; p=0.026). Conclusions: The effect of placebo in randomised control trials has increased across the years, but this field of research appears to be idle in recent years. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
4. Surgical management of degenerative disease of the lumbar spine
- Author
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Aulisa, L., Francesco Ciro TAMBURRELLI, Di Segni, F., Padua, R., and Santis, V.
5. Surgical management of instability of the lumbar spine
- Author
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Aulisa, L., Di Segni, F., Tamburrelli, F., Pitta, L., and Vincenzo De Santis
6. Obstetric Outcomes in Women on Lithium: A Systematic Review and Meta-Analysis.
- Author
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Callovini T, Montanari S, Bardi F, Barbonetti S, Rossi S, Caso R, Mandracchia G, Margoni S, Brugnami A, Paolini M, Manfredi G, Giudice LL, Segatori D, Zanzarri A, Onori L, Calderoni C, Benini E, Marano G, Massetti M, Fiaschè F, Di Segni F, Janiri D, Simonetti A, Moccia L, Grisoni F, Ruggiero S, Bartolucci G, Biscosi M, Ferrara OM, Bernardi E, Monacelli L, Giannico AM, De Berardis D, Battisti G, Ciliberto M, Brisi C, Lisci FM, D'Onofrio AM, Restaino A, Di Benedetto L, Anesini MB, Boggio G, Specogna E, Crupi A, De Chiara E, Caroppo E, Ieritano V, Monti L, Chieffo DPR, Rinaldi L, Camardese G, Cuomo I, Brugnoli R, Kotzalidis GD, Sani G, and Mazza M
- Abstract
Background/Objectives : Lithium taken during pregnancy was linked in the past with increased risk for foetal/newborn malformations, but clinicians believe that it is worse for newborn children not to treat the mothers' underlying psychiatric illness. We set to review the available evidence of adverse foetal outcomes in women who received lithium treatment for some time during their pregnancy. Methods : We searched four databases and a register to seek papers reporting neonatal outcomes of women who took lithium during their pregnancy by using the appropriate terms. We adopted the PRISMA statement and used Delphi rounds among all the authors to assess eligibility and the Cochrane Risk-of-Bias tool to evaluate the RoB of the included studies. Results : We found 28 eligible studies, 10 of which met the criteria for inclusion in the meta-analysis. The studies regarded 1402 newborn babies and 2595 women exposed to lithium. Overall, the systematic review found slightly increased adverse pregnancy outcomes for women taking lithium for both the first trimester only and any time during pregnancy, while the meta-analysis found increased odds for cardiac or other malformations, preterm birth, and a large size for gestational age with lithium at any time during pregnancy. Conclusions : Women with BD planning a pregnancy should consider discontinuing lithium when euthymic; lithium use during the first trimester and at any time during pregnancy increases the odds for some adverse pregnancy outcomes. Once the pregnancy has started, there is no reason for discontinuing lithium; close foetal monitoring and regular blood lithium levels may obviate some disadvantages of lithium administration during pregnancy.
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- 2024
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7. New pharmacotherapies to tackle the unmet needs in bipolar disorder: a focus on acute suicidality.
- Author
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Kotzalidis GD, Fiaschè F, Alcibiade A, Monti L, Di Segni F, Mazza M, and Sani G
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- Humans, Ketamine therapeutic use, Ketamine administration & dosage, Antidepressive Agents therapeutic use, Antidepressive Agents administration & dosage, Antipsychotic Agents therapeutic use, Antipsychotic Agents administration & dosage, Antimanic Agents therapeutic use, Antimanic Agents administration & dosage, Suicidal Ideation, Bipolar Disorder drug therapy, Suicide Prevention, Suicide psychology
- Abstract
Introduction: Suicidal behavior is relatively frequent in patients with bipolar disorder (BD) and constitutes their most frequent cause of death. Suicide rates remain high in patients with BD despite adherence to guidelines recommending lithium as first line, and/or antidepressants, antipsychotics, psychotherapy, psychosocial interventions, and electroconvulsive therapy. Hence the need to identify more effective and rapid anti-suicide interventions., Areas Covered: To tackle the unmet needs of pharmacotherapy, we investigated the PubMed database on 24-25 January 2024 using strategies like ('acute suicid*'[ti] OR 'suicide crisis syndrome' OR 'acute suicidal affective disturbance') AND (lithium[ti] OR clozapine[ti]), which obtained 3 results, and ('acute suicid*'[ti] OR 'suicide crisis syndrome' OR 'acute suicidal affective disturbance') AND (ketamine[ti] OR esketamine[ti] OR NMDA[ti] OR glutamat*[ti]), which yielded 14 results. We explored glutamatergic abnormalities in BD and suicide and found alterations in both. The noncompetitive NMDS antagonist ketamine and its S-enantiomer esketamine reportedly decrease acute suicidality., Expert Opinion: Intranasal esketamine or subcutaneous ketamine, single-bolus or intravenous, and possibly other glutamate receptor modulators may improve suicidal behavior in patients with unipolar and bipolar depression. This may be achieved through prompt remodulation of glutamate activity. The correct use of glutamatergic modulators could reduce acute suicidality and mortality in patients with BD.
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- 2024
- Full Text
- View/download PDF
8. Is Antipsychotic Drug Use During Pregnancy Associated with Increased Malformation Rates and Worsening of Maternal and Infant Outcomes? A Systematic Review.
- Author
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Sani G, Callovini T, Ferrara OM, Segatori D, Margoni S, Simonetti A, Lisci FM, Marano G, Fischetti A, Kotzalidis GD, Di Segni F, Fiaschè F, Janiri D, Moccia L, Manfredi G, Alcibiade A, Brisi C, Grisoni F, Stella G, Bernardi E, Brugnami A, Ciliberto M, Spera MC, Caso R, Rossi S, Boggio G, Mastroeni G, Abate F, Conte E, Quintano A, De Chiara L, Monti L, Camardese G, Rinaldi L, Koukopoulos AE, Chieffo DPR, Angeletti G, and Mazza M
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- Humans, Pregnancy, Female, Pregnancy Complications drug therapy, Pregnancy Outcome, Prenatal Exposure Delayed Effects chemically induced, Prenatal Exposure Delayed Effects epidemiology, Infant, Newborn, Antipsychotic Agents adverse effects, Abnormalities, Drug-Induced epidemiology
- Abstract
There is much debate about continuing antipsychotic medication in patients who need it when they become pregnant because benefits must be weighed against potential teratogenic and malformation effects related to antipsychotics themselves. To address this, we conducted a systematic review on the PubMed, PsycINFO and CINHAL databases and the ClinicalTrials.gov register using the following strategy: (toxicity OR teratogenicity OR malformation* OR "birth defect*" OR "congenital abnormality" OR "congenital abnormalities" OR "brain changes" OR "behavioral abnormalities" OR "behavioral abnormalities") AND antipsychotic* AND (pregnancy OR pregnant OR lactation OR delivery OR prenatal OR perinatal OR post-natal OR puerperium) on September 27, 2023. We found 38 studies to be eligible. The oldest was published in 1976, while most articles were recent. Most studies concluded that the antipsychotics, especially the second-generation antipsychotics, were devoid of teratogenic potential, while few studies were inconclusive and recommended replication. Most authoritative articles were from the Boston area, where large databases were implemented to study the malformation potential of psychiatric drugs. Other reliable databases are from Northern European registers. Overall conclusions are that antipsychotics are no more related to malformations than the disorders themselves; most studies recommend that there are no reasons to discontinue antipsychotic medications in pregnancy.
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- 2024
- Full Text
- View/download PDF
9. Non-Hodgkin's lymphoma: unexpected cause of shoulder pain. A systematic review of the literature.
- Author
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Caporale MF, Gambino GF, Larosa FS, Del Buono A, and Di Segni F
- Abstract
The non-Hodgkin lymphoma (NHL) is one of the most common shoulder neoplasms, especially the diffuse large B cell lymphoma (DLBCL). We report a rare case of shoulder pain in a 80-year-old man presenting with a six-month history of continuous severe pain to the right shoulder. Routine laboratory studies were normal. Shoulder MRI showed an in-growing inhomogeneous lesion in the anteromedial aspect of the right humeral head extended within the cortical bone of the humerus (osteolitic lesion), next to the surrounding soft tissues. He also underwent shoulder arthroscopy: the intra-articular involvement of the shoulder was therefore excluded. A percutaneous bone biopsy performed on the same day was diagnostic for lymphoma. Three days later, the patient underwent surgical excision of the mass; a reverse shoulder prosthesis was then implanted (Aequalis reversed prosthesis). The patient started chemiotherapy according with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) regimen, but did not tolerate it because of the sudden onset of herpes zoster. At 9-month follow-up, the patient is doing well, with fair range of motion, due to the delay of rehabilitation, but no shoulder pain and no evidence of local or systemic recurrence. A painful shoulder may be due to lymphoma even in the absence of classical symptoms. In suspected patients, plain radiographs should be followed by magnetic resonance imaging and bone biopsy. Tumor removal and shoulder arthroplasty can be an effective therapy. Given the devastating side effects of adjuvant chemotherapy, we do not recommend it in elderly patients.
- Published
- 2013
10. Surgical management of instability of the lumbar spine.
- Author
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Aulisa L, Di Segni F, Tamburrelli F, Pitta L, and De Santis V
- Subjects
- Humans, Joint Instability etiology, Spinal Diseases complications, Spinal Fractures complications, Spinal Fractures surgery, Spinal Stenosis complications, Spinal Stenosis surgery, Spondylolisthesis complications, Spondylolisthesis surgery, Joint Instability surgery, Lumbar Vertebrae surgery, Spinal Diseases surgery, Spinal Fusion methods
- Abstract
The surgical management of clinical spinal instability is for many aspects controversial since the lack of a precise clinical and instrumental definition of instability complicates the implementation of a therapeutic protocol. Both the indications and the surgical procedure are not always well defined. Some of the most common surgical techniques used in the most frequent causes of instability of the lumbar spine: fractures, degenerative disease and spondylolisthesis, are described.
- Published
- 2000
11. Surgical management of degenerative disease of the lumbar spine.
- Author
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Aulisa L, Tamburrelli F, Di Segni F, Padua R, and De Santis V
- Subjects
- Humans, Intervertebral Disc Chemolysis, Diskectomy methods, Intervertebral Disc Displacement surgery, Laminectomy methods, Lumbar Vertebrae, Spinal Stenosis surgery
- Abstract
With the advances in diagnostic and surgical procedures, for degenerative disease of the lumbar spine an aggressive therapeutic approach is more frequently indicated. The available surgical procedures are numerous and in continuing evolution. Most common surgical procedures used in major degenerative disease of the lumbar spine as disk herniation and stenosis are described. Indications, results and complications associated to these procedures are also illustrated.
- Published
- 2000
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