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254 results on '"Di Renzo, Antonio"'

1. Inflammation and acute cardiotoxicity in adult hematological patients treated with CAR-T cells: results from a pilot proof-of-concept study

Author

Camilli, Massimiliano, Viscovo, Marcello, Felici, Tamara, Maggio, Luca, Ballacci, Federico, Carella, Giacomo, Bonanni, Alice, Lamendola, Priscilla, Tinti, Lorenzo, Di Renzo, Antonio, Coarelli, Giulia, Galli, Eugenio, Liuzzo, Giovanna, Burzotta, Francesco, Montone, Rocco Antonio, Sorà, Federica, Sica, Simona, Hohaus, Stefan, Lanza, Gaetano Antonio, Crea, Filippo, Lombardo, Antonella, and Minotti, Giorgio

Published
2024
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2. AFG3L2 and ACO2-Linked Dominant Optic Atrophy: Genotype–Phenotype Characterization Compared to OPA1 Patients

Author

Amore, Giulia, Romagnoli, Martina, Carbonelli, Michele, Cascavilla, Maria Lucia, De Negri, Anna Maria, Carta, Arturo, Parisi, Vincenzo, Di Renzo, Antonio, Schiavi, Costantino, Lenzetti, Chiara, Zenesini, Corrado, Ormanbekova, Danara, Palombo, Flavia, Fiorini, Claudio, Caporali, Leonardo, Carelli, Valerio, Barboni, Piero, and La Morgia, Chiara

Published
2024
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6. Neurophysiological Effects of Withdrawal from Acute Overused Medications in Chronic Migraine with Medication-Overuse Headache.

Author

Sebastianelli, Gabriele, Casillo, Francesco, Abagnale, Chiara, Di Renzo, Antonio, Ziccardi, Lucia, Parisi, Vincenzo, Di Lorenzo, Cherubino, Serrao, Mariano, and Coppola, Gianluca

Subjects
MEDICATION overuse headache, MEDICATION abuse, SOMATOSENSORY evoked potentials, NEURAL stimulation, ULNAR nerve
Abstract

Background/Objectives: Chronic migraine with medication-overuse headache (CM-MOH) is neurophysiologically characterized by increased cortical excitability with sensitization at both the thalamocortical and the cortical levels. It is unclear whether the increased cortical excitability could be reverted by medication withdrawal (i.e., brain state) or whether it is a brain trait of individuals predisposed to medication overuse. In this study, we aim to investigate whether withdrawal from overused drugs can influence and restore these neurophysiological abnormalities. Methods: Somatosensory evoked potentials (SSEPs) were elicited by electrical stimulation of the median nerve (M), the ulnar nerve (U), and the simultaneous stimulation of both nerves (MU) in 14 patients with CM-MOH before (T0) and after (T1) a three-week withdrawal protocol and, for comparison, in 14 healthy volunteers (HVs) of a comparable age distribution. We measured the level of thalamocortical (pre-HFO) and cortical activation (post-HFO) by analyzing the high-frequency oscillations (HFOs) embedded in parietal N20 median SSEPs. Furthermore, we calculated the habituation and the degree of cortical lateral inhibition (dLI) of N20-P25 low-frequency SSEPs. Results: After the three-week withdrawal protocol (T1), we observed a normalization of the baseline habituation deficit (T0: +0.10 ± 0.54; T1: −0.53 ± 0.8; p = 0.040) and a reduction in the amplitude for both pre-HFO (p < 0.009) and post-HFO (p = 0.042), with values comparable to those of the HVs. However, no effects were observed on the dLI (p = 0.141). Conclusions: Our findings showed that withdrawal from overused drugs could affect the increased excitability of the non-painful somatosensory system in patients with CM-MOH, reducing the level of sensitization at both the thalamocortical and the cortical levels. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Local Dynamic Stability of Trunk During Gait Can Detect Dynamic Imbalance in Subjects with Episodic Migraine.

Author

Castiglia, Stefano Filippo, Sebastianelli, Gabriele, Abagnale, Chiara, Casillo, Francesco, Trabassi, Dante, Di Lorenzo, Cherubino, Ziccardi, Lucia, Parisi, Vincenzo, Di Renzo, Antonio, De Icco, Roberto, Tassorelli, Cristina, Serrao, Mariano, and Coppola, Gianluca

Abstract

Background/Hypothesis: Motion sensitivity symptoms, such as dizziness or unsteadiness, are frequently reported as non-headache symptoms of migraine. Postural imbalance has been observed in subjects with vestibular migraine, chronic migraine, and aura. We aimed to assess the ability of largest Lyapunov's exponent for a short time series (sLLE), which reflects the ability to cope with internal perturbations during gait, to detect differences in local dynamic stability between individuals with migraine without aura (MO) with an episodic pattern between attacks and healthy subjects (HS). Methods: Trunk accelerations of 47 MO and 38 HS were recorded during gait using an inertial measurement unit. The discriminative ability of sLLE was assessed through receiver-operating characteristics curves and cutoff analysis. Partial correlation analysis was conducted between the clinical and gait variables, excluding the effects of gait speed. Results: MO showed higher sLLE values, and reduced pelvic rotation, pelvic tilt, and stride length values. sLLEML and pelvic rotation showed good ability to discriminate between MO and HS and were correlated with the perceived pain, migraine disability assessment score, and each other. Conclusions: these findings may provide new insights into the postural balance control mechanism in subjects with MO and introduce the sLLEML as a potential measure of dynamic instability in MO. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Decoding Visual Responses: Insights into Chronic Migraine and Medication Overuse Headache with Electrophysiological Analysis.

Author

Coppola, Gianluca, Casillo, Francesco, Sebastianelli, Gabriele, Abagnale, Chiara, Di Lorenzo, Cherubino, Di Renzo, Antonio, Serrao, Mariano, and Parisi, Vincenzo

Subjects
MEDICATION overuse headache, VISUAL evoked potentials, MEDICATION abuse, TREATMENT effectiveness, VISUAL cortex
Abstract

Background/Objectives: Habituation and sensitization are opposite phenomena that play a role in the pathophysiology of episodic migraine and its progression to chronic migraine (CM). There have been just a few studies that have investigated these phenomena in patients with medication overuse headache (MOH) in comparison to those with chronic migraine (CM) and healthy controls (HCs), and the findings have been inconsistent. Methods: We measured and examined visual evoked potentials (VEPs) in 81 patients with MOH and 24 patients with CM, as well as 24 HCs. The VEPs were used to assess sensitization by analysing the amplitude of the first block (100 sweeps) and to evaluate habituation by measuring the amplitude response decrement after six blocks. We further examined patients diagnosed with MOH based on their acute medication type and after a 3-week acute medication withdrawal program. Results: There were no significant differences between groups in terms of the first N1-P1 VEP amplitude block and its habituation. It was found that patients with MOH had a greater drop in the amplitude of the VEP P1-N2 complex after repeated stimulation than patients with CM or HC. The VEP parameters showed no significant differences based on the specific overused drug and after a 3-week acute medication withdrawal. Conclusions: We propose that the results obtained in patients with MOH indicate an abnormal activation of inhibitory circuits in the parieto-occipital region in response to repeated modulatory stimuli. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Lack of a direct link between macular cones function and photophobia in interictal migraine.

Author

Casillo, Francesco, Di Renzo, Antonio, Sebastianelli, Gabriele, Abagnale, Chiara, Martelli, Francesco, Di Lorenzo, Cherubino, Serrao, Mariano, Falsini, Benedetto, Parisi, Vincenzo, and Coppola, Gianluca

Subjects
*PEARSON correlation (Statistics), *MIGRAINE aura, *VISUAL evoked potentials, *VISUAL pathways, *VISUAL cortex
Abstract

Background: It is still debatable whether the mechanisms underlying photophobia are related to altered visual cortex excitability or specific abnormalities of colour-related focal macular retino-thalamic information processing. Methods: This cross-sectional study examined Ganzfeld blue-red (B-R) and blue-yellow (B-Y) focal macular cone flash ERG (ffERG) and focal-flash visual evoked potentials (ffVEPs) simultaneously in a group of migraine patients with (n = 18) and without (n = 19) aura during the interictal phase, in comparison to a group of healthy volunteers (HVs) (n = 20). We correlate the resulting retinal and cortical electrophysiological responses with subjective discomfort from exposure to bright light verified on a numerical scale. Results: Compared to HVs, the amplitude and phase of the first and second harmonic of ffERG and ffVEPs were non-significantly different in migraine patients without aura and migraine patients with aura for both the B-R and the B-Y focal stimuli. Pearson's correlation test did not disclose correlations between clinical variables, including the photophobia scale and electrophysiological variables. Conclusions: These results do not favour interictal functional abnormalities in L-M- and S-cone opponent visual pathways in patients with migraine. They also suggest that the discomfort resulting from exposure to bright light is not related to focal macular retinal-to-visual cortex pathway. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Clinical Characteristics, Management, and Outcomes in Cardiogenic Shock: Insights From a High-Volume Italian Cardiac Intensive Care Unit.

Author

Del Buono, Marco Giuseppe, La Vecchia, Giulia, D'Aiello, Alessia, Pedicino, Daniela, Pinnacchio, Gaetano, Genuardi, Lorenzo, Montone, Rocco Antonio, Saponara, Gianluigi, Di Renzo, Antonio, Conte, Cristina, Cribari, Francesco, Moroni, Francesco, Filomia, Simone, Brecciaroli, Mattia, Aurigemma, Cristina, Liuzzo, Giovanna, Trani, Carlo, Burzotta, Francesco, and Sanna, Tommaso

Published
2024
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13. Comparison of Baseline and Post-Nitrate Exercise Testing in Patients with Angina but Non-Obstructed Coronary Arteries with Different Acetylcholine Test Results

Author

Marino, Angelo Giuseppe, primary, Gentile, Giuseppe, additional, Lenci, Ludovica, additional, De Benedetto, Fabio, additional, Tremamunno, Saverio, additional, Cambise, Nello, additional, Belmusto, Antonietta, additional, Di Renzo, Antonio, additional, Tinti, Lorenzo, additional, De Vita, Antonio, additional, and Lanza, Gaetano Antonio, additional

Published
2024
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17. Optical Coherence Tomography in Alzheimer’s Disease: A Meta-Analysis

Author

Coppola, Gianluca, Di Renzo, Antonio, Ziccardi, Lucia, Martelli, Francesco, Fadda, Antonello, Manni, Gianluca, Barboni, Piero, Pierelli, Francesco, Sadun, Alfredo A, and Parisi, Vincenzo

Subjects
Acquired Cognitive Impairment, Aging, Biomedical Imaging, Neurosciences, Brain Disorders, Neurodegenerative, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease, Aged, Alzheimer Disease, Case-Control Studies, Demography, Humans, Publication Bias, Retina, Tomography, Optical Coherence, General Science & Technology
Abstract

BackgroundAlzheimer's disease (AD) is a neurodegenerative disorder, which is likely to start as mild cognitive impairment (MCI) several years before the its full-blown clinical manifestation. Optical coherence tomography (OCT) has been used to detect a loss in peripapillary retina nerve fiber layer (RNFL) and a reduction in macular thickness and volume of people affected by MCI or AD. Here, we performed an aggregate meta-analysis combining results from different studies.Methods and findingsData sources were case-control studies published between January 2001 and August 2014 (identified through PubMed and Google Scholar databases) that examined the RNFL thickness by means of OCT in AD and MCI patients compared with cognitively healthy controls.Results11 studies were identified, including 380 patients with AD, 68 with MCI and 293 healthy controls (HC). The studies suggest that the mean RNFL thickness is reduced in MCI (weighted mean differences in μm, WMD = -13.39, 95% CI: -17.34 to -9.45, p = 0.031) and, even more so, in AD (WMD = -15.95, 95% CI: -21.65 to -10.21, p

Published
2015

18. Topographical Correlation between Structural and Functional Impairment of the Macular Inner Retinal Layers in Multiple Sclerosis Eyes with a History of Optic Neuropathy

Author

Parisi, Vincenzo, primary, Barbano, Lucilla, additional, Antonelli, Giulio, additional, Nicoletti, Carolina Gabri, additional, Landi, Doriana, additional, Mataluni, Giorgia, additional, Di Renzo, Antonio, additional, Buttari, Fabio, additional, Marfia, Girolama Alessandra, additional, Centonze, Diego, additional, and Ziccardi, Lucia, additional

Published
2023
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27. Whole brain surface-based morphometry and tract-based spatial statistics in migraine with aura patients: difference between pure visual and complex auras

Author

Abagnale, Chiara, primary, Di Renzo, Antonio, additional, Sebastianelli, Gabriele, additional, Casillo, Francesco, additional, Tinelli, Emanuele, additional, Giuliani, Giada, additional, Tullo, Maria Giulia, additional, Serrao, Mariano, additional, Parisi, Vincenzo, additional, Fiorelli, Marco, additional, Caramia, Francesca, additional, Schoenen, Jean, additional, Di Piero, Vittorio, additional, and Coppola, Gianluca, additional

Published
2023
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28. Effects of Botulinum Toxin Type A on the Nociceptive and Lemniscal Somatosensory Systems in Chronic Migraine: An Electrophysiological Study

Author

Sebastianelli, Gabriele, primary, Casillo, Francesco, additional, Di Renzo, Antonio, additional, Abagnale, Chiara, additional, Cioffi, Ettore, additional, Parisi, Vincenzo, additional, Di Lorenzo, Cherubino, additional, Serrao, Mariano, additional, Pierelli, Francesco, additional, Schoenen, Jean, additional, and Coppola, Gianluca, additional

Published
2023
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30. 415 DOES MYOCARDIAL BRIDGING TRIGGER MYOCARDIAL ISCHEMIA?

Author

Tremamunno, Saverio, primary, Pastena, Paola, additional, Cambise, Nello, additional, Telesca, Alessandro, additional, Tinti, Lorenzo, additional, Di Renzo, Antonio, additional, De Vita, Antonio, additional, Lamendola, Priscilla, additional, Lombardo, Antonella, additional, Crea, Filippo, additional, and Lanza, Gaetano Antonio, additional

Published
2022
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34. A Hypothalamic Mechanism Regulates the Duration of a Migraine Attack: Insights from Microstructural and Temporal Complexity of Cortical Functional Networks Analysis

Author

Porcaro, Camillo, primary, Di Renzo, Antonio, additional, Tinelli, Emanuele, additional, Parisi, Vincenzo, additional, Di Lorenzo, Cherubino, additional, Caramia, Francesca, additional, Fiorelli, Marco, additional, Giuliani, Giada, additional, Cioffi, Ettore, additional, Seri, Stefano, additional, Di Piero, Vittorio, additional, Pierelli, Francesco, additional, Di Lorenzo, Giorgio, additional, and Coppola, Gianluca, additional

Published
2022
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40. A Hypothalamic Mechanism Regulates the Duration of a Migraine Attack::Insights from Microstructural and Temporal Complexity of Cortical Functional Networks Analysis

Author

Tuttolomondo, Antonino, Simonetta, Irene, Porcaro, Camillo, Di Renzo, Antonio, Tinelli, Emanuele, Parisi, Vincenzo, Di Lorenzo, Cherubino, Caramia, Francesca, Fiorelli, Marco, Giuliani, Giada, Cioffi, Ettore, Seri, Stefano, Di Piero, Vittorio, Pierelli, Francesco, Di Lorenzo, Giorgio, Coppola, Gianluca, Tuttolomondo, Antonino, Simonetta, Irene, Porcaro, Camillo, Di Renzo, Antonio, Tinelli, Emanuele, Parisi, Vincenzo, Di Lorenzo, Cherubino, Caramia, Francesca, Fiorelli, Marco, Giuliani, Giada, Cioffi, Ettore, Seri, Stefano, Di Piero, Vittorio, Pierelli, Francesco, Di Lorenzo, Giorgio, and Coppola, Gianluca

Abstract

The role of the hypothalamus and the limbic system at the onset of a migraine attack has recently received significant interest. We analyzed diffusion tensor imaging (DTI) parameters of the entire hypothalamus and its subregions in 15 patients during a spontaneous migraine attack and in 20 control subjects. We also estimated the non-linear measure resting-state functional MRI BOLD signal’s complexity using Higuchi fractal dimension (FD) and correlated DTI/fMRI findings with patients’ clinical characteristics. In comparison with healthy controls, patients had significantly altered diffusivity metrics within the hypothalamus, mainly in posterior ROIs, and higher FD values in the salience network (SN). We observed a positive correlation of the hypothalamic axial diffusivity with migraine severity and FD of SN. DTI metrics of bilateral anterior hypothalamus positively correlated with the mean attack duration. Our results show plastic structural changes in the hypothalamus related to the attacks severity and the functional connectivity of the SN involved in the multidimensional neurocognitive processing of pain. Plastic changes to the hypothalamus may play a role in modulating the duration of the attack.

Published
2022

44. Pathophysiological Bases of Comorbidity in Migraine

Author

Altamura, Claudia, primary, Corbelli, Ilenia, additional, de Tommaso, Marina, additional, Di Lorenzo, Cherubino, additional, Di Lorenzo, Giorgio, additional, Di Renzo, Antonio, additional, Filippi, Massimo, additional, Jannini, Tommaso B., additional, Messina, Roberta, additional, Parisi, Pasquale, additional, Parisi, Vincenzo, additional, Pierelli, Francesco, additional, Rainero, Innocenzo, additional, Raucci, Umberto, additional, Rubino, Elisa, additional, Sarchielli, Paola, additional, Li, Linxin, additional, Vernieri, Fabrizio, additional, Vollono, Catello, additional, and Coppola, Gianluca, additional

Published
2021
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