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2. Direct Aortic Versus Supra-Aortic Arterial Cannulation During Surgery for Acute Type A Aortic Dissection

Author

Juvonen, Tatu, Jormalainen, Mikko, Mustonen, Caius, Demal, Till, Fiore, Antonio, Perrotti, Andrea, Hervé, Amélie, Mazzaro, Enzo, Gatti, Giuseppe, Pettinari, Matteo, Peterss, Sven, Buech, Joscha, Nappi, Francesco, Conradi, Lenard, Pinto, Angel G., Rodriguez Lega, Javier, Pol, Marek, Kacer, Petr, Dell’Aquila, Angelo M., Rukosujew, Andreas, Wisniewski, Konrad, Vendramin, Igor, Piani, Daniela, Ferrante, Luisa, Rinaldi, Mauro, Quintana, Eduard, Pruna-Guillen, Robert, Gerelli, Sebastien, Di Perna, Dario, Folliguet, Thierry, Acharya, Metesh, Field, Mark, Kuduvalli, Manoj, Onorati, Francesco, Rossetti, Cecilia, Mäkikallio, Timo, Raivio, Peter, Mariscalco, Giovanni, and Biancari, Fausto

Published
2023
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3. Interinstitutional analysis of the outcome after surgery for type A aortic dissection

Author

Biancari, Fausto, Dell’Aquila, Angelo M., Gatti, Giuseppe, Perrotti, Andrea, Hervé, Amélie, Touma, Joseph, Pettinari, Matteo, Peterss, Sven, Buech, Joscha, Wisniewski, Konrad, Juvonen, Tatu, Jormalainen, Mikko, Mustonen, Caius, Rukosujew, Andreas, Demal, Till, Conradi, Lenard, Pol, Marek, Kacer, Petr, Onorati, Francesco, Rossetti, Cecilia, Vendramin, Igor, Piani, Daniela, Rinaldi, Mauro, Ferrante, Luisa, Quintana, Eduard, Pruna-Guillen, Robert, Lega, Javier Rodriguez, Pinto, Angel G., Acharya, Metesh, El-Dean, Zein, Field, Mark, Harky, Amer, Kuduvalli, Manoj, Nappi, Francesco, Gerelli, Sebastien, Di Perna, Dario, Mazzaro, Enzo, Rosato, Stefano, Fiore, Antonio, and Mariscalco, Giovanni

Published
2023
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4. Nature of Neurological Complications and Outcome After Surgery for Type A Aortic Dissection

Author

Biancari, Fausto, Onorati, Francesco, Peterss, Sven, Buech, Joscha, Mariscalco, Giovanni, Lega, Javier Rodriguez, Pinto, Angel G., Fiore, Antonio, Perrotti, Andrea, Hérve, Amelié, Rukosujew, Andreas, Demal, Till, Conradi, Lenard, Wisniewski, Konrad, Pol, Marek, Kacer, Petr, Gatti, Giuseppe, Mazzaro, Enzo, Vendramin, Igor, Piani, Daniela, Rinaldi, Mauro, Ferrante, Luisa, Pruna-Guillen, Robert, Di Perna, Dario, Gerelli, Sebastien, El-Dean, Zein, Nappi, Francesco, Field, Mark, Kuduvalli, Manoj, Pettinari, Matteo, Francica, Alessandra, Jormalainen, Mikko, Dell'Aquila, Angelo M., Mäkikallio, Timo, Juvonen, Tatu, and Quintana, Eduard

Published
2024
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5. Classification of the Urgency of the Procedure and Outcome of Acute Type A Aortic Dissection

Author

Biancari, Fausto, Dell'Aquila, Angelo M., Onorati, Francesco, Rossetti, Cecilia, Demal, Till, Rukosujew, Andreas, Peterss, Sven, Buech, Joscha, Fiore, Antonio, Folliguet, Thierry, Perrotti, Andrea, Hervé, Amélie, Nappi, Francesco, Conradi, Lenard, Pinto, Angel G., Lega, Javier Rodriguez, Pol, Marek, Kacer, Petr, Wisniewski, Konrad, Mazzaro, Enzo, Gatti, Giuseppe, Vendramin, Igor, Piani, Daniela, Ferrante, Luisa, Rinaldi, Mauro, Quintana, Eduard, Pruna-Guillen, Robert, Gerelli, Sebastien, Di Perna, Dario, Acharya, Metesh, Mariscalco, Giovanni, Field, Mark, Kuduvalli, Manoj, Pettinari, Matteo, Rosato, Stefano, Mustonen, Caius, Kiviniemi, Tuomas, Roberts, Charles S., Mäkikallio, Timo, and Juvonen, Tatu

Published
2024
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6. Preoperative arterial lactate and outcome after surgery for type A aortic dissection: The ERTAAD multicenter study

Author

Biancari, Fausto, Nappi, Francesco, Gatti, Giuseppe, Perrotti, Andrea, Hervé, Amélie, Rosato, Stefano, D'Errigo, Paola, Pettinari, Matteo, Peterss, Sven, Buech, Joscha, Juvonen, Tatu, Jormalainen, Mikko, Mustonen, Caius, Demal, Till, Conradi, Lenard, Pol, Marek, Kacer, Petr, Dell’Aquila, Angelo M., Wisniewski, Konrad, Vendramin, Igor, Piani, Daniela, Ferrante, Luisa, Mäkikallio, Timo, Quintana, Eduard, Pruna-Guillen, Robert, Fiore, Antonio, Folliguet, Thierry, Mariscalco, Giovanni, Acharya, Metesh, Field, Mark, Kuduvalli, Manoj, Onorati, Francesco, Rossetti, Cecilia, Gerelli, Sebastien, Di Perna, Dario, Mazzaro, Enzo, Pinto, Angel G., Lega, Javier Rodriguez, and Rinaldi, Mauro

Published
2023
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7. Current Outcome after Surgery for Type A Aortic Dissection

Author

Biancari, Fausto, Juvonen, Tatu, Fiore, Antonio, Perrotti, Andrea, Hervé, Amélie, Touma, Joseph, Pettinari, Matteo, Peterss, Sven, Buech, Joscha, Dell’Aquila, Angelo M., Wisniewski, Konrad, Rukosujew, Andreas, Demal, Till, Conradi, Lenard, Pol, Marek, Kacer, Petr, Onorati, Francesco, Rossetti, Cecilia, Vendramin, Igor, Piani, Daniela, Rinaldi, Mauro, Ferrante, Luisa, Quintana, Eduard, Pruna-Guillen, Robert, Rodriguez Lega, Javier, Pinto, Angel G., Acharya, Metesh, El-Dean, Zein, Field, Mark, Harky, Amer, Nappi, Francesco, Gerelli, Sebastien, Di Perna, Dario, Gatti, Giuseppe, Mazzaro, Enzo, Rosato, Stefano, Raivio, Peter, Jormalainen, Mikko, and Mariscalco, Giovanni

Published
2023
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8. Diameter and dissection of the abdominal aorta and the risk of distal aortic reoperation after surgery for type A aortic dissection

Author

Biancari, Fausto, primary, Perrotti, Andrea, additional, Juvonen, Tatu, additional, Mariscalco, Giovanni, additional, Pettinari, Matteo, additional, Lega, Javier Rodriguez, additional, Di Perna, Dario, additional, Mäkikallio, Timo, additional, Onorati, Francesco, additional, Wisniewki, Konrad, additional, Demal, Till, additional, Pol, Marek, additional, Gatti, Giuseppe, additional, Vendramin, Igor, additional, Rinaldi, Mauro, additional, Quintana, Eduard, additional, Peterss, Sven, additional, Field, Mark, additional, and Fiore, Antonio, additional

Published
2024
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9. Duration of Venoarterial Extracorporeal Membrane Oxygenation and Mortality in Postcardiotomy Cardiogenic Shock

Author

Mariscalco, Giovanni, El-Dean, Zein, Yusuff, Hakeem, Fux, Thomas, Dell'Aquila, Angelo M., Jónsson, Kristján, Ragnarsson, Sigurdur, Fiore, Antonio, Dalén, Magnus, di Perna, Dario, Gatti, Giuseppe, Juvonen, Tatu, Zipfel, Svante, Perrotti, Andrea, Bounader, Karl, Alkhamees, Khalid, Loforte, Antonio, Lechiancole, Andrea, Pol, Marek, Spadaccio, Cristiano, Pettinari, Matteo, De Keyzer, Dieter, Welp, Henryk, Maselli, Daniele, Lichtenberg, Artur, Ruggieri, Vito G., and Biancari, Fausto

Published
2021
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10. Baseline risk factors of in-hospital mortality after surgery for acute type A aortic dissection: an ERTAAD study

Author

Biancari, Fausto, primary, Demal, Till, additional, Nappi, Francesco, additional, Onorati, Francesco, additional, Francica, Alessandra, additional, Peterss, Sven, additional, Buech, Joscha, additional, Fiore, Antonio, additional, Folliguet, Thierry, additional, Perrotti, Andrea, additional, Hervé, Amélie, additional, Conradi, Lenard, additional, Rukosujew, Andreas, additional, Pinto, Angel G., additional, Lega, Javier Rodriguez, additional, Pol, Marek, additional, Rocek, Jan, additional, Kacer, Petr, additional, Wisniewski, Konrad, additional, Mazzaro, Enzo, additional, Vendramin, Igor, additional, Piani, Daniela, additional, Ferrante, Luisa, additional, Rinaldi, Mauro, additional, Quintana, Eduard, additional, Pruna-Guillen, Robert, additional, Gerelli, Sebastien, additional, Di Perna, Dario, additional, Acharya, Metesh, additional, Mariscalco, Giovanni, additional, Field, Mark, additional, Kuduvalli, Manoj, additional, Pettinari, Matteo, additional, Rosato, Stefano, additional, D’Errigo, Paola, additional, Jormalainen, Mikko, additional, Mustonen, Caius, additional, Mäkikallio, Timo, additional, Dell’Aquila, Angelo M., additional, Juvonen, Tatu, additional, and Gatti, Giuseppe, additional

Published
2024
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11. Bleeding and thrombotic events in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study

Author

Mansour, Alexandre, Flecher, Erwan, Schmidt, Matthieu, Rozec, Bertrand, Gouin-Thibault, Isabelle, Esvan, Maxime, Fougerou, Claire, Levy, Bruno, Porto, Alizée, Ross, James, Para, Marylou, Manganiello, Sabrina, Lebreton, Guillaume, Vincentelli, André, Nesseler, Nicolas, Pierrot, Marc, Chocron, Sidney, Flicoteaux, Guillaume, Mauriat, Philippe, Ouattara, Alexandre, Roze, Hadrien, Huet, Olivier, Fischer, Marc-Olivier, Alessandri, Claire, Bellaïche, Raphel, Constant, Ophélie, de Roux, Quentin, Ly, André, Meffert, Arnaud, Merle, Jean-Claude, Mongardon, Nicolas, Picard, Lucile, Skripkina, Elena, Folliguet, Thierry, Fiore, Antonio, D’ostrevy, Nicolas, Morgan, Marie-Catherine, Guinot, Pierre-Grégoire, Nguyen, Maxime, Gaide-Chevronnay, Lucie, Terzi, Nicolas, Colin, Gwenhaël, Fabre, Olivier, Astaneh, Arash, Issard, Justin, Fadel, Elie, Fabre, Dominique, Girault, Antoine, Guihaire, Julien, Ion, Iolande, Menager, Jean Baptiste, Mitilian, Delphine, Mercier, Olaf, Stephan, François, Thes, Jacques, Jouan, Jerôme, Duburcq, Thibault, Loobuyck, Valentin, Moussa, Mouhammed, Mugnier, Agnes, Rousse, Natacha, Desebbe, Olivier, Fellahi, Jean-Luc, Henaine, Roland, Pozzi, Matteo, Richard, Jean-Christophe, Riad, Zakaria, Guervilly, Christophe, Hraiech, Sami, Papazian, Laurent, Castanier, Matthias, Chanavaz, Charles, Cadoz, Cyril, Gette, Sebastien, Louis, Guillaume, Portocarrero, Erick, Gaudard, Philippe, Brini, Kais, Bischoff, Nicolas, Kimmoun, Antoine, Mattei, Mathieu, Perez, Pierre, Bourdiol, Alexandre, Hourmant, Yannick, Mahé, Pierre-Joachim, Jaquet, Pierre, Lortat-Jacob, Brice, Mordant, Pierre, Nataf, Patrick, Patrier, Juliette, Provenchère, Sophie, Roué, Morgan, Sonneville, Romain, Tran-Dinh, Alexy, Wicky, Paul-Henri, Al Zreibi, Charles, Cholley, Bernard, Guyonvarch, Yannis, Hamada, Sophie, Harrois, Anatole, Matiello, Jordi, Kerforne, Thomas, Lacroix, Corentin, Brechot, Nicolas, Combes, Alain, Chommeloux, Juliette, Constantin, Jean Michel, D’alessandro, Cosimo, Demondion, Pierre, Demoule, Alexandre, Dres, Martin, Fadel, Guillaume, Fartoukh, Muriel, Hekimian, Guillaume, Juvin, Charles, Leprince, Pascal, Levy, David, Luyt, Charles Edouard, Pineton de Chambrun, Marc, Schoell, Thibaut, Fillâtre, Pierre, Massart, Nicolas, Nicolas, Roxane, Jonas, Maud, Vidal, Charles, Allou, Nicolas, Muccio, Salvatore, Di Perna, Dario, Ruggieri, Vito-Giovanni, Mourvillier, Bruno, Anselmi, Amedeo, Bounader, Karl, Launey, Yoann, Lebouvier, Thomas, Parasido, Alessandro, Reizine, Florian, Seguin, Philippe, Besnier, Emmanuel, Carpentier, Dorothée, Clavier, Thomas, Falcoz, Pierre-Emmanuel, Olland, Anne, Villard, Marion, Bounes, Fanny, Labaste, François, Minville, Vincent, Guillon, Antoine, Fedun, Yannick, CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de Réanimation Médicale [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Hôpital de la Timone [CHU - APHM] (TIMONE), University of California [Davis] (UC Davis), University of California (UC), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Lille, Institut de cardiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 (RNMCD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), and This work was supported by a grant from the university hospital of Rennes (Appel à projets CFTR2) and by a grant from the French society of thoracic and cardio-vascular surgery (Société française de chirurgie thoracique et cardio-vasculaire, Bourse Marc Laskar).

Subjects
Anticoagulation, [SDV]Life Sciences [q-bio], Bleeding, COVID-19, Thrombosis, ECMO, Critical Care and Intensive Care Medicine
Abstract

International audience; Purpose: To describe bleeding and thrombotic events and their risk factors in patients receiving extracorporeal membrane oxygenation (ECMO) for severe coronavirus disease 2019 (COVID-19) and to evaluate their impact on in-hospital mortality.Methods: The ECMOSARS registry included COVID-19 patients supported by ECMO in France. We analyzed all patients included up to March 31, 2022 without missing data regarding bleeding and thrombotic events. The association of bleeding and thrombotic events with in-hospital mortality and pre-ECMO variables was assessed using multivariable logistic regression models.Results: Among 620 patients supported by ECMO, 29% had only bleeding events, 16% only thrombotic events and 20% both bleeding and thrombosis. Cannulation site (18% of patients), ear nose and throat (12%), pulmonary bleeding (9%) and intracranial hemorrhage (8%) were the most frequent bleeding types. Device-related thrombosis and pulmonary embolism/thrombosis accounted for most of thrombotic events. In-hospital mortality was 55.7%. Bleeding events were associated with in-hospital mortality (adjusted odds ratio (adjOR) = 2.91[1.94-4.4]) but not thrombotic events (adjOR = 1.02[0.68-1.53]). Intracranial hemorrhage was strongly associated with in-hospital mortality (adjOR = 13.5[4.4-41.5]). Ventilation duration before ECMO ≥ 7 days and length of ECMO support were associated with bleeding. Thrombosis-associated factors were fibrinogen ≥ 6 g/L and length of ECMO support.Conclusions: In a nationwide cohort of COVID-19 patients supported by ECMO, bleeding incidence was high and associated with mortality. Intracranial hemorrhage incidence was higher than reported for non-COVID patients and carried the highest risk of death. Thrombotic events were less frequent and not associated with mortality. Length of ECMO support was associated with a higher risk of both bleeding and thrombosis, supporting the development of strategies to minimize ECMO duration.

Published
2022

12. Veno-Arterial Extracorporeal Membrane Oxygenation for Circulatory Failure in COVID-19 Patients: Insights from the ECMOSARS Registry

Author

Anselmi, Amedeo, Mansour, Alexandre, Para, Marylou, Mongardon, Nicolas, Porto, Alizée, Guihaire, Julien, Morgant, Marie-Catherine, Pozzi, Matteo, Cholley, Bernard, Falcoz, Pierre-Emmanuel, Gaudard, Philippe, Lebreton, Guillaume, Labaste, François, Barbanti, Claudio, Fouquet, Olivier, Chocron, Sidney, Mottard, Nicolas, Esvan, Maxime, Fougerou-Leurent, Claire, Flecher, Erwan, Vincentelli, André, Nesseler, Nicolas, Pierrot, Marc, Flicoteaux, Guillaume, Mauriat, Philippe, Ouattara, Alexandre, Roze, Hadrien, Huet, Olivier, Fischer, Marc-Olivier, Alessandri, Claire, Bellaïche, Raphel, Constant, Ophélie, Roux, Quentin, Ly, André, Meffert, Arnaud, Merle, Jean-Claude, Picard, Lucile, Skripkina, Elena, Folliguet, Thierry, Fiore, Antonio, d'Ostrevy, Nicolas, Morgan, Marie-Catherine, Guinot, Pierre-Grégoire, Nguyen, Maxime, Gaide-Chevronnay, Lucie, Terzi, Nicolas, Colin, Gwenhaël, Fabre, Olivier, Astaneh, Arash, Issard, Justin, Fadel, Elie, Fabre, Dominique, Girault, Antoine, Ion, Iolande, Menager, Jean Baptiste, Mitilian, Delphine, Mercier, Olaf, Stephan, François, Thes, Jacques, Jouan, Jerôme, Duburcq, Thibault, Loobuyck, Valentin, Moussa, Mouhammed, Mugnier, Agnes, Rousse, Natacha, Manganiello, Sabrina, Desebbe, Olivier, Fellahi, Jean-Luc, Henaine, Roland, Richard, Jean-Christophe, Riad, Zakaria, Guervilly, Christophe, Hraiech, Sami, Papazian, Laurent, Castanier, Matthias, Chanavaz, Charles, Cadoz, Cyril, Gette, Sebastien, Louis, Guillaume, Portocarrero, Erick, Brini, Kais, Bischoff, Nicolas, Levy, Bruno, Kimmoun, Antoine, Mattei, Mathieu, Perez, Pierre, Bourdiol, Alexandre, Hourmant, Yannick, Mahé, Pierre-Joachim, Rozec, Bertrand, Vourc’h, Mickaël, Aubert, Stéphane, Bazalgette, Florian, Roger, Claire, Jaquet, Pierre, Lortat-Jacob, Brice, Mordant, Pierre, Nataf, Patrick, Patrier, Juliette, Provenchere, Sophie, Roué, Morgan, Sonneville, Romain, Tran-Dinh, Alexy, Wicky, Paul-Henri, Al Zreibi, Charles, Guyonvarch, Yannis, Hamada, Sophie, Bertier, Astrid, Harrois, Anatole, Matiello, Jordi, Kerforne, Thomas, Lacroix, Corentin, Brechot, Nicolas, Combes, Alain, Schmidt, Matthieu, Chommeloux, Juliette, Constantin, Jean Michel, D’alessandro, Cosimo, Demondion, Pierre, Demoule, Alexandre, Dres, Martin, Fadel, Guillaume, Fartoukh, Muriel, Hekimian, Guillaume, Juvin, Charles, Leprince, Pascal, Levy, David, Luyt, Charles Edouard, Pineton de Chambrun, Marc, Schoell, Thibaut, Fillâtre, Pierre, Massart, Nicolas, Nicolas, Roxane, Jonas, Maud, Vidal, Charles, Allou, Nicolas, Muccio, Salvatore, Di Perna, Dario, Ruggieri, Vito-Giovanni, Mourvillier, Bruno, Bounader, Karl, Launey, Yoann, Lebouvier, Thomas, Parasido, Alessandro, Reizine, Florian, Seguin, Philippe, Besnier, Emmanuel, Carpentier, Dorothée, Clavier, Thomas, Olland, Anne, Villard, Marion, Bounes, Fanny, Minville, Vincent, Guillon, Antoine, Fedun, Yannick, Ross, James, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), IMRB - PROTECT/'Pharmacologie et Technologies pour les Maladies Cardiovasculaires' [Créteil] (U955 Inserm - UPEC), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Pôle des Cardiopathies Congénitales du Nouveau-Né à L'adulte - Centre Constitutif Cardiopathies Congénitales Complexes M3C, Groupe Hospitalier Paris Saint-Joseph, Hôpital Marie-Lannelongue, Inserm U999, Université Paris-Saclay, Research on Healthcare Performance (RESHAPE - Inserm U1290 - UCBL1), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Franco-czech Laboratory for clinical research on obesity, Charles University [Prague] (CU)-Institut National de la Santé et de la Recherche Médicale (INSERM), MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Nutrition, Métabolismes et Cancer (NuMeCan), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Heart Failure, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, VA-ECMO, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Outcomes, Covid-19
Abstract

International audience; Objectives: The clinical profile and outcomes of patients with Covid-19 who require veno-arterial or veno-venous-arterial extracorporeal membrane oxygenation (VA-ECMO - VAV-ECMO) are poorly understood. We aimed to describe the characteristics and outcomes of these patients and to identify predictors of both favorable and unfavorable outcomes.Methods: ECMOSARS is a multicenter, prospective, nationwide French registry enrolling patients who require VV/VA-ECMO in the context of Covid-19 infection (652 patients at 41 centers). We focused on 47 patients supported with VA- or VAV-ECMO for refractory cardiogenic shock.Results: Median age was 49. 14% of patients had a prior diagnosis of heart failure. The most common etiologies of cardiogenic shock were acute pulmonary embolism (30%), myocarditis (28%), and acute coronary syndrome (4%). E-CPR (Extracorporeal Cardiopulmonary Resuscitation) occurred in 38%. In-hospital survival was 28% in the whole cohort, and 43% when E-CPR patients were excluded. ECMO cannulation was associated with significant improvements in pH and FiO2 on day one, but non-survivors showed significantly more severe acidosis and higher FiO2 than survivors at this point (p = 0.030 and p = 0.006). Other factors associated with death were greater age (p = 0.02), higher BMI (p = 0.03), E-CPR (p = 0.001), non-myocarditis etiology (p = 0.02), higher serum lactates (p = 0.004), epinephrine (but not noradrenaline) use before initiation of ECMO (p = 0.003), hemorrhagic complications (p = 0.001), greater transfusion requirements (p = 0.001), and more severe SAVE and SAFE scores (p = 0.01 and p = 0.03).Conclusions: We report the largest focused analysis of VA- and VAV-ECMO recipients in Covid-19. Although relatively rare, the need for temporary mechanical circulatory support in these patients is associated with poor prognosis. However, VA-ECMO remains a viable solution to rescue carefully selected patients. We identified factors associated with poor prognosis and suggest that E-CPR is not a reasonable indication for VA-ECMO in this population.

Published
2023

13. Outcome after Surgery for Iatrogenic Acute Type A Aortic Dissection

Author

Biancari, Fausto, primary, Pettinari, Matteo, additional, Mariscalco, Giovanni, additional, Mustonen, Caius, additional, Nappi, Francesco, additional, Buech, Joscha, additional, Hagl, Christian, additional, Fiore, Antonio, additional, Touma, Joseph, additional, Dell’Aquila, Angelo M., additional, Wisniewski, Konrad, additional, Rukosujew, Andreas, additional, Perrotti, Andrea, additional, Hervé, Amélie, additional, Demal, Till, additional, Conradi, Lenard, additional, Pol, Marek, additional, Kacer, Petr, additional, Onorati, Francesco, additional, Rossetti, Cecilia, additional, Vendramin, Igor, additional, Piani, Daniela, additional, Rinaldi, Mauro, additional, Ferrante, Luisa, additional, Quintana, Eduard, additional, Pruna-Guillen, Robert, additional, Rodriguez Lega, Javier, additional, Pinto, Angel G., additional, Mäkikallio, Timo, additional, Acharya, Metesh, additional, El-Dean, Zein, additional, Field, Mark, additional, Harky, Amer, additional, Gerelli, Sebastien, additional, Di Perna, Dario, additional, Jormalainen, Mikko, additional, Gatti, Giuseppe, additional, Mazzaro, Enzo, additional, Juvonen, Tatu, additional, and Peterss, Sven, additional

Published
2022
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14. Five-year survival after post-cardiotomy veno-arterial extracorporeal membrane oxygenation

Author

Biancari, Fausto, primary, Perrotti, Andrea, additional, Ruggieri, Vito G, additional, Mariscalco, Giovanni, additional, Dalén, Magnus, additional, Dell’Aquila, Angelo M, additional, Jónsson, Kristján, additional, Ragnarsson, Sigurdur, additional, Di Perna, Dario, additional, Bounader, Karl, additional, Gatti, Giuseppe, additional, Juvonen, Tatu, additional, Alkhamees, Khalid, additional, Yusuff, Hakeem, additional, Loforte, Antonio, additional, Lechiancole, Andrea, additional, Chocron, Sidney, additional, Pol, Marek, additional, Spadaccio, Cristiano, additional, Pettinari, Matteo, additional, De Keyzer, Dieter, additional, Fiore, Antonio, additional, and Welp, Henryk, additional

Published
2021
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18. La simulazione su manichino migliora l’abilità degli studenti di Medicina nell’auscultazione cardiaca? L’esperienza di Pavia

Author

Boldrini, Michele, Mussinelli, Roberta, Alogna, Alessio, Di Perna, Dario, Raimondi, Ambra, Grassi, Sara, Totaro, Rossana, Vecchio, Chiara, Musca, Francesco, Salinaro, Francesco, and Perlini, Stefano

Abstract

L’esame fisico è il punto di partenza di ogni diagnosi cardiologica, nonostante l’eccessiva specializzazione spesso conduca a trascurare le abilità cliniche e ad enfatizzare eccessivamente l’approccio strumentale alla diagnosi. La mancanza di tempo da parte dei docenti e dei tutor, la difficoltà a reperire il paziente tipico con reperti adeguati all’insegnamento al letto del malato, il rispetto nei confronti del paziente e una scarsa stima dell’importanza delle abilità cliniche conducono tutti ad un progressivo impoverimento dell’insegnamento. Harvey© è un manichino simulatore basato sulla possibilità di valutare più di 50 diagnosi cardiologiche introdotto presso l’Università di Miami (Florida, USA). Uno dei vantaggi del simulatore Harvey© risiede nella possibilità di ascoltare, comparare e valutare suoni cardiaci realistici. Per testarne oggetivamente il potenziale didattico, si è valutata in 130 studenti del III anno di medicina (ossia all’inizio della loro esperienza clinica) la capacità di riconoscere 5 diverse diagnosi cardiologiche (difetto del setto interatriale, soggetto giovane normale, stenosi mitralica con rigurgito tricuspidalico, rigurgito mitralico e pericardite) tra 50 possibilità diagnostiche, prima e dopo 10 ore di addestramento con Harvey©. Nessuno di loro aveva precedente esperienza di auscultazione cardiaca simulata. Come atteso, le capacità diagnostiche sono risultate scarse nei principianti, che hanno riconosciuto correttamente solo l’11% dei reperti cardiaci proposti. Dopo l’addestramento guidato al simulatore, tali capacità sono nettamente migliorate (72%; p, Bollettino della Società Medico Chirurgica di Pavia, Vol 125, N° 4 (2012)

Published
2013
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19. Role of gender in short- and long-term outcomes after surgery for type A aortic dissection: analysis of a multicentre European registry.

Author

Onorati F, Francica A, Demal T, Nappi F, Peterss S, Buech J, Fiore A, Folliguet T, Perrotti A, Hervé A, Conradi L, Dell'Aquila AM, Rukosujew A, Pinto AG, Lega JR, Pol M, Rocek J, Kacer P, Wisniewski K, Mazzaro E, Vendramin I, Piani D, Ferrante L, Rinaldi M, Quintana E, Pruna-Guillen R, Gerelli S, Acharya M, Mariscalco G, Field M, Kuduvalli M, Pettinari M, Rosato S, D'Errigo P, Jormalainen M, Mustonen C, Mäkikallio T, Di Perna D, Juvonen T, Gatti G, Luciani GB, and Biancari F

Subjects
Humans, Male, Female, Retrospective Studies, Europe epidemiology, Middle Aged, Aged, Sex Factors, Treatment Outcome, Reoperation statistics & numerical data, Aortic Aneurysm, Thoracic surgery, Aortic Aneurysm, Thoracic mortality, Postoperative Complications epidemiology, Propensity Score, Aortic Dissection surgery, Aortic Dissection mortality, Registries
Abstract

Objectives: Gender difference in the outcome after type A aortic dissection (TAAD) surgery remains an issue of ongoing debate. In this study, we aimed to evaluate the impact of gender on the short- and long-term outcome after surgery for TAAD., Methods: A multicentre European registry retrospectively included all consecutive TAAD surgery patients between 2005 and 2021 from 18 hospitals across 8 European countries. Early and late mortality, and cumulative incidence of aortic reoperation were compared between genders., Results: A total of 3902 patients underwent TAAD surgery, with 1185 (30.4%) being females. After propensity score matching, 766 pairs of males and females were compared. No statistical differences were detected in the early postoperative outcome between genders. Ten-year survival was comparable between genders (47.8% vs 47.1%; log-rank test, P = 0.679), as well as cumulative incidences of distal or proximal aortic reoperations. Ten-year relative survival compared to country-, year-, age- and sex-matched general population was higher among males (0.65) compared to females (0.58). The time-period subanalysis revealed advancements in surgical techniques in both genders over the years. However, an increase in stroke was observed over time for both populations, particularly among females., Conclusions: The past 16 years have witnessed marked advancements in surgical techniques for TAAD in both males and females, achieving comparable early and late mortality rates. Despite these findings, late relative survival was still in favour of males., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)

Published
2024
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20. Predictors, prognosis and costs of prolonged intensive care unit stay after surgery for type A aortic dissection.

Author

Biancari F, Hérve A, Peterss S, Radner C, Buech J, Pettinari M, Rodriguez Lega J, Pinto AG, Fiore A, Onorati F, Francica A, Wisniewski K, Demal T, Conradi L, Rocek J, Kacer P, Gatti G, Vendramin I, Rinaldi M, Ferrante L, Pruna-Guillen R, Quintana E, DI Perna D, Mariscalco G, Jormalainen M, Field M, Harky A, Dell'aquila AM, Juvonen T, Mäkikallio T, and Perrotti A

Subjects
Humans, Male, Female, Middle Aged, Aged, Prognosis, Aortic Aneurysm surgery, Aortic Aneurysm economics, Aortic Aneurysm mortality, Aortic Dissection surgery, Aortic Dissection economics, Aortic Dissection mortality, Length of Stay economics, Intensive Care Units economics, Hospital Mortality
Abstract

Background: The outcomes after prolonged treatment in the intensive care unit (ICU) after surgery for Stanford type A aortic dissection (TAAD) have not been previously investigated., Methods: This analysis included 3538 patients from a multicenter study who underwent surgery for acute TAAD and were admitted to the cardiac surgical ICU., Results: The mean length of stay in the cardiac surgical ICU was 9.9±9.5 days. The mean overall costs of treatment in the cardiac surgical ICU 24086±32084 €. In-hospital mortality was 14.8% and 5-year mortality was 30.5%. Adjusted analyses showed that prolonged ICU stay was associated with significantly lower risk of in-hospital mortality (adjusted OR 0.971, 95%CI 0.959-0.982), and of five-year mortality (adjusted OR 0.970, 95%CI 0.962-0.977), respectively. Propensity score matching analysis yielded 870 pairs of patients with short ICU stay (2-5 days) and long ICU stay (>5 days) with balanced baseline, operative and postoperative variables. Patients with prolonged ICU stay (>5 days) had significantly lower in-hospital mortality (8.9% vs. 17.4%, <0.001) and 5-year mortality (28.2% vs. 30.7%, P=0.007) compared to patients with short ICU-stay (2-5 days)., Conclusions: Prolonged ICU stay was common after surgery for acute TAAD. However, when adjusted for multiple baseline and operative variables as well as adverse postoperative events and the cluster effect of hospitals, it was associated with favorable survival up to 5 years after surgery.

Published
2024
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21. Femoral arterial cannulation for surgical repair of stanford type A aortic dissection.

Author

Juvonen T, Vendramin I, Mariscalco G, Jormalainen M, Perrotti A, Hervé A, Mazzaro E, Gatti G, Pettinari M, Peterss S, Buech J, Nappi F, Pinto AG, Rodriguez Lega J, Pol M, Rocek J, Kacer P, Rukosujew A, Wisniewski K, Piani D, Demal T, Conradi L, Ferrante L, Rinaldi M, Quintana E, Pruna-Guillen R, Gerelli S, Di Perna D, Fiore A, Folliguet T, Acharya M, El-Dean Z, Field M, Kuduvalli M, Onorati F, Francica A, Mäkikallio T, Dell'Aquila AM, Mustonen C, Raivio P, Rosato S, and Biancari F

Subjects
Aged, Female, Humans, Male, Middle Aged, Aortic Aneurysm, Thoracic surgery, Aortic Aneurysm, Thoracic mortality, Catheterization methods, Catheterization, Peripheral methods, Propensity Score, Retrospective Studies, Treatment Outcome, Aortic Dissection surgery, Aortic Dissection mortality, Femoral Artery surgery, Hospital Mortality
Abstract

Background: The benefits and harms associated with femoral artery cannulation over other sites of arterial cannulation for surgical repair of acute Stanford type A aortic dissection (TAAD) are not conclusively established., Methods: We evaluated the outcomes after surgery for TAAD using femoral artery cannulation, supra-aortic arterial cannulation (i.e., innominate/subclavian/axillary artery cannulation), and direct aortic cannulation., Results: 3751 (96.1%) patients were eligible for this analysis. In-hospital mortality using supra-aortic arterial cannulation was comparable to femoral artery cannulation (17.8% vs. 18.4%; adjusted OR 0.846, 95% CI 0.799-1.202). This finding was confirmed in 1028 propensity score-matched pairs of patients with supra-aortic arterial cannulation or femoral artery cannulation (17.5% vs. 17.0%, p = 0.770). In-hospital mortality after direct aortic cannulation was lower compared to femoral artery cannulation (14.0% vs. 18.4%, adjusted OR 0.703, 95% CI 0.529-0.934). Among 583 propensity score-matched pairs of patients, direct aortic cannulation was associated with lower rates of in-hospital mortality (13.4% vs. 19.6%, p = 0.004) compared to femoral artery cannulation. Switching of the primary site of arterial cannulation was associated with increased rate of in-hospital mortality (36.5% vs. 17.0%; adjusted OR 2.730, 95% CI 1.564-4.765). Ten-year mortality was similar in the study cohorts., Conclusions: In this study, the outcomes of surgery for TAAD using femoral arterial cannulation were comparable to those using supra-aortic arterial cannulation. However, femoral arterial cannulation was associated with higher in-hospital mortality than direct aortic cannulation., Trial Registration: ClinicalTrials.gov registration code: NCT04831073., (© 2024 International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC).)

Published
2024
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22. Aortic arch surgery for DeBakey type 1 aortic dissection in patients aged 60 years or younger.

Author

Biancari F, Lega JR, Mariscalco G, Peterss S, Buech J, Fiore A, Perrotti A, Rukosujew A, Pinto AG, Demal T, Wisniewski K, Pol M, Gatti G, Vendramin I, Rinaldi M, Pruna-Guillen R, Di Perna D, El-Dean Z, Sherzad H, Nappi F, Field M, Pettinari M, Jormalainen M, Dell'Aquila AM, Onorati F, Quintana E, Juvonen T, and Mäkikallio T

Subjects
Humans, Male, Female, Middle Aged, Aortic Aneurysm, Thoracic surgery, Aortic Aneurysm, Thoracic mortality, Adult, Retrospective Studies, Treatment Outcome, Europe epidemiology, Propensity Score, Aortic Dissection surgery, Aortic Dissection mortality, Aorta, Thoracic surgery, Reoperation statistics & numerical data, Postoperative Complications epidemiology, Blood Vessel Prosthesis Implantation methods, Blood Vessel Prosthesis Implantation adverse effects, Blood Vessel Prosthesis Implantation mortality
Abstract

Background: Extended aortic repair is considered a key issue for the long-term durability of surgery for DeBakey type 1 aortic dissection. The risk of aortic degeneration may be higher in young patients due to their long life expectancy. The early outcome and durability of aortic surgery in these patients were investigated in the present study., Methods: The subjects of the present analysis were patients under 60 years old who underwent surgical repair for acute DeBakey type 1 aortic dissection at 18 cardiac surgery centres across Europe between 2005 and 2021. Patients underwent ascending aortic repair or total aortic arch repair using the conventional technique or the frozen elephant trunk technique. The primary outcome was 5-year cumulative incidence of reoperation on the distal aorta., Results: Overall, 915 patients underwent surgical ascending aortic repair and 284 patients underwent surgical total aortic arch repair. The frozen elephant trunk procedure was performed in 128 patients. Among 245 propensity score-matched pairs, total aortic arch repair did not decrease the rate of distal aortic reoperation compared to ascending aortic repair (5-year cumulative incidence, 6.7% versus 6.7%, subdistributional hazard ratio 1.127, 95% c.i. 0.523 to 2.427). Total aortic arch repair increased the incidence of postoperative stroke/global brain ischaemia (25.7% versus 18.4%, P = 0.050) and dialysis (19.6% versus 12.7%, P = 0.003). Five-year mortality was comparable after ascending aortic repair and total aortic arch repair (22.8% versus 27.3%, P = 0.172)., Conclusions: In patients under 60 years old with DeBakey type 1 aortic dissection, total aortic arch replacement compared with ascending aortic repair did not reduce the incidence of distal aortic operations at 5 years. When feasible, ascending aortic repair for DeBakey type 1 aortic dissection is associated with satisfactory early and mid-term outcomes., Trial Registration: ClinicalTrials.gov Identifier: NCT04831073., (© The Author(s) 2024. Published by Oxford University Press on behalf of BJS Foundation Ltd.)

Published
2024
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23. Resection and double pericardial patch repair of a congenital aneurysm of the mitral-aortic intervalvular fibrosa.

Author

Di Perna D, Raisky O, Bonnet D, Bentz J, Bayard NF, and Gerelli S

Subjects
Female, Humans, Animals, Cattle, Mitral Valve surgery, Aortic Valve surgery, Aorta, Aneurysm, False surgery, Aneurysm complications
Abstract

Mitral-aortic intervalvular fibrosa aneurysms and pseudoaneurysms are rare entities but can lead to different, unpredictable and sometime dramatic complications. We report the case of a young woman presenting a congenital form of this aneurysm. Given the clinical and symptomatological progression, surgical treatment is mandatory. After a transverse aortotomy, we resected the aneurysm. Performing a pulmonary arteriotomy allows adequate control of the left main coronary artery, adjacent to the lesion. We repaired the remaining cavity, not far from the left coronary aortic cusp, with a double patch of bovine pericardium., (© The Author 2023. Published by MMCTS on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)

Published
2023
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