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1. Experimenting the design-based k-NN approach for mapping and estimation under forest management planning

Author

Mattioli W, Quatrini V, Di Paolo S, Di Santo D, Giuliarelli D, Angelini A, Portoghesi L, and Corona P

Subjects
Forest management planning, k-Nearest Neighbors, Landsat, Estimation, Mapping, Forestry, SD1-669.5
Abstract

Estimation and mapping of forest attributes are a fundamental support for forest management planning. This study describes a practical experimentation concerning the use of design-based k-Nearest Neighbors (k-NN) approach to estimate and map selected attributes in the framework of inventories at forest management level. The study area was the Chiarino forest within the Gran Sasso and Monti della Laga National Park (central Italy). Aboveground biomass and current annual increment of tree volume were selected as the attributes of interest for the test. Field data were acquired within 28 sample plots selected by stratified random sampling. Satellite data were acquired by a Landsat 5 TM multispectral image. Attributes from field surveys and Landsat image processing were coupled by k-NN to predict the attributes of interest for each pixel of the Landsat image. Achieved results demonstrate the effectiveness of the k-NN approach for statistical estimation, that is compatible with the produced forest attribute raster maps and also proves to be characterized, in the considered study case, by a precision double than that obtained by conventional inventory based on field sample plots only.

Published
2012
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7. Risk factors and action thresholds for the novel coronavirus pandemic. Insights from the Italian Society of Nephrology COVID-19 Survey

Author

Nordio, M., Reboldi, G., Di Napoli, A., Quintaliani, G., Alberici, F., Postorino, M., Aucella, F., Messa, P., Brunori, G., Bosco, M., Malberti, F., Mandreoli, M., Mazzaferro, S., Movilli, E., Ravera, M., Salomone, M., Santoro, D., Postorinolimido, M. A., Bonomini, M., Stingone, A., Maccarone, M., Di Loreto, E., Stacchiotti, L., Malandra, R., Chiarella, S., D'Agostino, F., Fuiano, G., Nicodemo, L., Bonofiglio, R., Greco, S., Mallamaci, F., Barreca, E., Caserta, C., Bruzzese, V., Galati, D., Tramontana, D., Viscione, M., Chiuchiolo, L., Tuccillo, S., Sepe, M., Vitale, F., Ciriana, E., Martignetti, V., Caserta, D., Stizzo, A., Romano, A., Iulianiello, G., Cascone, E., Minicone, P., Chiricone, D., Delgado, G., Barbato, A., Celentano, S., Molfino, I., Coppola, S., Raiola, I., Abategiovanni, M., Borrelli, S., Margherita, C., Bruno, F., Ida, M., Aliperti, E., Potito, D., Cuomo, G., De Luca, M., Merola, M., Botta, C., Garofalo, G., Alinei, P., Paglionico, C., Roano, M., Vitale, S., Ierardi, R., Fimiani, V., Conte, G., Di Natale, G., Romano, M., Di Marino, V., Scafarto, A., Meccariello, S., Pecoraro, C., Di Stazio, E., Di Meglio, E., Cuomo, A., Maresca, B., Rotaia, E., Capasso, G., Auricchio, M., Pluvio, C., Maddalena, L., De Maio, A., Palladino, G., Buono, F., Gigliotti, G., Mancini, E., La Manna, G., Storari, A., Mosconi, G., Cappelli, G., Scarpioni, R., Gregorini, M., Rigotti, A., Mancini, W., Bianco, F., Boscutti, G., Amici, G., Tosto, M., Fini, R., Pace, G., Cioffi, A., Boccia, E., Di Lullo, L., Di Zazzo, G., Simonelli, R., Bondatti, F., Miglio, L., Rifici, N., Treglia, A., Muci, M., Baldinelli, G., Rizzi, E., Lonzi, M., De Cicco, C., Forte, F., De Paolis, P., Grandaliano, Giuseppe, Cuzziol, C., Torre, V. M., Sfregola, P., Rossi, V., Fabio, G., Flammini, A., Filippini, A., Onorato, L., Vendola, F., Di Daniela, N., Alfarone, C., Scabbia, L., Ferrazzano, M., Grotta, B. D., Gamberini, M., Fazzari, L., Mene, P., Morgia, A., Catucci, A., Palumbo, R., Puliti, M., Marinelli, R., Polito, P., Marrocco, F., Morabito, S., Rocca, R., Nazzaro, L., Lavini, R., Iamundo, V., Chiappini, M., Casarci, M., Morosetti, M., Hassan, S., Firmi, G., Galliani, M., Serraiocco, M., Feriozzi, S., Valentini, W., Sacco, P., Garibotto, G., Cappelli, V., Saffioti, C., Repetto, M., Rolla, D., Lorenz, M., Pedrini, L., Polonioli, D., Galli, E., Ruggenenti, P., Scolari, F., Bove, S., Costantino, E., Bracchi, M., Mangano, S., Depetri, G., La Milia, V., Farina, M., Zecchini, S., Savino, R., Melandri, M., Guastoni, C., Paparella, M., Gallieni, M., Minetti, E., Bisegna, S., Righetti, M., Badalamenti, S., Alberghini, E., Bertoli, S., Fabbrini, P., Albrizio, P., Rampino, T., Colturi, C., Rombola, G., Lucatello, A., Guerrini, E., Ranghino, A., Lenci, F., Fanciulli, E., Santarelli, S., Damiani, C., Garofalo, D., Sopranzi, F., Santoferrara, A., Di Luca, M., Galiotta, P., Brigante, M., Manganaro, M., Maffei, S., Berto, I., Besso, L., Viglino, G., Cusinato, S., Chiarinottichiappero, D. F., Tognarelli, G., Gianoglio, B., Forneris, G., Biancone, L., Savoldi, S., Vitale, C., Boero, R., Filiberti, O., Borzumati, M., Gesualdo, L., Lomonte, C., Gernone, G., Pallotta, G., Di Paolo, S., Vernaglione, L., Specchio, A., Stallone, G., Dell'Aquila, R., Sandri, G., Russo, F., Napoli, M., Marangi, A., Morrone, L., Di Stratis, C., Fresu, A., Cicu, F., Murtas, S., Manca, O., Pani, A., Pilloni, M., Pistis, R., Cadoni, M., Contu, B., Logias, F., Ivaldi, R., Fancello, S., Cossu, M., Lepori, G., Vittoria, S., Battiati, E., Arnone, M., Rome, M., Barbera, A., Granata, A., Collura, G., Dico, C. L., Pugliese, G., Di Natale, E., Rizzari, G., Cottone, L., Longo, N., Battaglia, G., Marcantoni, C., Giannetto, G., Tumino, G., Randazzo, F., Bellissimo, L., Faro, F. L., Grippaldi, F., Urso, S., Quattrone, G., Todaro, I., Vincenzo, D., Murgo, A., Masuzzo, M., Pisacane, A., Monardo, P., Pontorierro, M., Quari, C., Bauro, A., Chimenz, R. R., Alfio, D., Girasole, F., Cascio, A. L., Caviglia, A., Tornese, F., Sirna, F., Altieri, C., Cusumano, R., Saveriano, V., La Corte, A., Locascio, G., Rotolo, U., Musso, S., Risuglia, L., Blanco, G., Minardo, G., Castellino, S., Zappulla, Z., Randone, S., Di Francesca, M., Cassetti, C. C., Oddo, G., Buscaino, G., Mucaria, F., Barraco, V. I., Di Martino, A., Rallo, D., Dani, L., Campolo, G., Manescalchi, F., Biagini, M., Agate, M., Panichi, V., Casani, A., Traversari, L., Garosi, G., Tabbi, M., Selvi, A., Cencioni, L., Fagugli, R., Timio, F., Leveque, A., Manes, M., Mennella, G., Calo, L., Fiorini, F., Abaterusso, C., Calzavara, P., Meneghel, G., Bonesso, C., Gambaro, G., Gammaro, L., Rugiu, C., Ronco, C., Nordio M., Reboldi G., Di Napoli A., Quintaliani G., Alberici F., Postorino M., Aucella F., Messa P., Brunori G., Bosco M., Malberti F., Mandreoli M., Mazzaferro S., Movilli E., Ravera M., Salomone M., Santoro D., PostorinoLimido M.A., Bonomini M., Stingone A., Maccarone M., Di Loreto E., Stacchiotti L., Malandra R., Chiarella S., D'Agostino F., Fuiano G., Nicodemo L., Bonofiglio R., Greco S., Mallamaci F., Barreca E., Caserta C., Bruzzese V., Galati D., Tramontana D., Viscione M., Chiuchiolo L., Tuccillo S., Sepe M., Vitale F., Ciriana E., Martignetti V., Caserta D., Stizzo A., Romano A., Iulianiello G., Cascone E., Minicone P., Chiricone D., Delgado G., Barbato A., Celentano S., Molfino I., Coppola S., Raiola I., Abategiovanni M., Borrelli S., Margherita C., Bruno F., Ida M., Aliperti E., Potito D., Cuomo G., De Luca M., Merola M., Botta C., Garofalo G., Alinei P., Paglionico C., Roano M., Vitale S., Ierardi R., Fimiani V., Conte G., Di Natale G., Romano M., Di Marino V., Scafarto A., Meccariello S., Pecoraro C., Di Stazio E., Di Meglio E., Cuomo A., Maresca B., Rotaia E., Capasso G., Auricchio M., Pluvio C., Maddalena L., De Maio A., Palladino G., Buono F., Gigliotti G., Mancini E., La Manna G., Storari A., Mosconi G., Cappelli G., Scarpioni R., Gregorini M., Rigotti A., Mancini W., Bianco F., Boscutti G., Amici G., Tosto M., Fini R., Pace G., Cioffi A., Boccia E., Di Lullo L., Di Zazzo G., Simonelli R., Bondatti F., Miglio L., Rifici N., Treglia A., Muci M., Baldinelli G., Rizzi E., Lonzi M., De Cicco C., Forte F., De Paolis P., Grandaliano G., Cuzziol C., Torre V.M., Sfregola P., Rossi V., Fabio G., Flammini A., Filippini A., Onorato L., Vendola F., Di Daniela N., Alfarone C., Scabbia L., Ferrazzano M., Grotta B.D., Gamberini M., Fazzari L., Mene P., Morgia A., Catucci A., Palumbo R., Puliti M., Marinelli R., Polito P., Marrocco F., Morabito S., Rocca R., Nazzaro L., Lavini R., Iamundo V., Chiappini M., Casarci M., Morosetti M., Hassan S., Firmi G., Galliani M., Serraiocco M., Feriozzi S., Valentini W., Sacco P., Garibotto G., Cappelli V., Saffioti C., Repetto M., Rolla D., Lorenz M., Pedrini L., Polonioli D., Galli E., Ruggenenti P., Scolari F., Bove S., Costantino E., Bracchi M., Mangano S., Depetri G., La Milia V., Farina M., Zecchini S., Savino R., Melandri M., Guastoni C., Paparella M., Gallieni M., Minetti E., Bisegna S., Righetti M., Badalamenti S., Alberghini E., Bertoli S., Fabbrini P., Albrizio P., Rampino T., Colturi C., Rombola G., Lucatello A., Guerrini E., Ranghino A., Lenci F., Fanciulli E., Santarelli S., Damiani C., Garofalo D., Sopranzi F., Santoferrara A., Di Luca M., Galiotta P., Brigante M., Manganaro M., Maffei S., Berto I., Besso L., Viglino G., Cusinato S., ChiarinottiChiappero D.F., Tognarelli G., Gianoglio B., Forneris G., Biancone L., Savoldi S., Vitale C., Boero R., Filiberti O., Borzumati M., Gesualdo L., Lomonte C., Gernone G., Pallotta G., Di Paolo S., Vernaglione L., Specchio A., Stallone G., Dell'Aquila R., Sandri G., Russo F., Napoli M., Marangi A., Morrone L., Di Stratis C., Fresu A., Cicu F., Murtas S., Manca O., Pani A., Pilloni M., Pistis R., Cadoni M., Contu B., Logias F., Ivaldi R., Fancello S., Cossu M., Lepori G., Vittoria S., Battiati E., Arnone M., Rome M., Barbera A., Granata A., Collura G., Dico C.L., Pugliese G., Di Natale E., Rizzari G., Cottone L., Longo N., Battaglia G., Marcantoni C., Giannetto G., Tumino G., Randazzo F., Bellissimo L., Faro F.L., Grippaldi F., Urso S., Quattrone G., Todaro I., Vincenzo D., Murgo A., Masuzzo M., Pisacane A., Monardo P., Pontorierro M., Quari C., Bauro A., Chimenz R.R., Alfio D., Girasole F., Cascio A.L., Caviglia A., Tornese F., Sirna F., Altieri C., Cusumano R., Saveriano V., La Corte A., Locascio G., Rotolo U., Musso S., Risuglia L., Blanco G., Minardo G., Castellino S., Zappulla Z., Randone S., Di Francesca M., Cassetti C.C., Oddo G., Buscaino G., Mucaria F., Barraco V.I., Di Martino A., Rallo D., Dani L., Campolo G., Manescalchi F., Biagini M., Agate M., Panichi V., Casani A., Traversari L., Garosi G., Tabbi M., Selvi A., Cencioni L., Fagugli R., Timio F., Leveque A., Manes M., Mennella G., Calo L., Fiorini F., Abaterusso C., Calzavara P., Meneghel G., Bonesso C., Gambaro G., Gammaro L., Rugiu C., and Ronco C.

Subjects
Male, Contextual analysis, medicine.medical_treatment, Population, 030232 urology & nephrology, Recursive partitioning, 030204 cardiovascular system & hematology, Rate ratio, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Classification tree, COVID-19, Renal replacement therapy, Risk Factors, Medical, Surveys and Questionnaires, Health care, medicine, Settore MED/14 - NEFROLOGIA, Humans, education, Pandemics, Societies, Medical, Female, Italy, Nephrology, education.field_of_study, business.industry, Multilevel model, Decision rule, Confidence interval, Original Article, Hemodialysis, business, Contextual analysi, Societies, Demography
Abstract

Background and aim: Over 80% (365/454) of the nation’s centers participated in the Italian Society of Nephrology COVID-19 Survey. Out of 60,441 surveyed patients, 1368 were infected as of April 23rd, 2020. However, center-specific proportions showed substantial heterogeneity. We therefore undertook new analyses to identify explanatory factors, contextual effects, and decision rules for infection containment. Methods: We investigated fixed factors and contextual effects by multilevel modeling. Classification and Regression Tree (CART) analysis was used to develop decision rules. Results: Increased positivity among hemodialysis patients was predicted by center location [incidence rate ratio (IRR) 1.34, 95% confidence interval (CI) 1.20–1.51], positive healthcare workers (IRR 1.09, 95% CI 1.02–1.17), test-all policy (IRR 5.94, 95% CI 3.36–10.45), and infected proportion in the general population (IRR 1.002, 95% CI 1.001–1.003) (all p < 0.01). Conversely, lockdown duration exerted a protective effect (IRR 0.95, 95% CI 0.94–0.98) (p < 0.01). The province-contextual effects accounted for 10% of the total variability. Predictive factors for peritoneal dialysis and transplant cases were center location and infected proportion in the general population. Using recursive partitioning, we identified decision thresholds at general population incidence ≥ 229 per 100,000 and at ≥ 3 positive healthcare workers. Conclusions: Beyond fixed risk factors, shared with the general population, the increased and heterogeneous proportion of positive patients is related to the center’s testing policy, the number of positive patients and healthcare workers, and to contextual effects at the province level. Nephrology centers may adopt simple decision rules to strengthen containment measures timely.

Published
2021

22. Taking Care of Relationships in the Intensive Care Unit: Positive Impact on Family Consent for Organ Donation

Author

Bocci, M.G., primary, D'Alò, C., additional, Barelli, R., additional, Inguscio, S., additional, Prestifilippo, A., additional, Di Paolo, S., additional, Lochi, S., additional, Fanfarillo, M., additional, Grieco, D.L., additional, Maviglia, R., additional, Caricato, A., additional, Mistraletti, G., additional, Pulitanò, S., additional, Antonelli, M., additional, and Sandroni, C., additional

Published
2016
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23. Giovanni Francesco Pavini delle Carte

Author

Di Paolo S., Vari, I. Birocchi, E. Cortese, A. Mattone, M. Miletti, and Di Paolo, S.

Subjects
Pavini, Stampa incunabola, Rota Romana
Published
2013

24. Beyond Design and Style: Enhancing the Material Dimension of Artefacts through Technological Complexity

Author

Di Paolo S.

Subjects
levantine ivories technology iconography
Abstract

Levantine ivories of the Iron Age have been the topic of much research aimed at answering some fundamental questions. The role assigned to style as the main criterion for differentiation of ivories and their place of manufacture (city-based workshops/production areas) provided an important frame of reference. But the art of crafting involves many other aspects, among which is the strict relationship between humans and artefacts. This special interaction traverses the borders of typological, stylistic, and technical aspects, because it ascribes to the artefacts a hermeneutic value no less important than that of society and individuals. Material had a special significance in the pre-industrial societies. A symbolic or even magical value could be the result of transforming and exalting the materiality of an artifact.

Published
2015

26. Sirolimus for Kaposi's Sarcoma in Renal-Transplant Recipients

Author

Barbara Infante, Giuseppe Grandaliano, Giovanni Stallone, Francesco Paolo Schena, Loreto Gesualdo, Maggio G, Antonio Schena, Di Paolo S, Antonia Loverre, and Elena Ranieri

Subjects
Male, Vascular Endothelial Growth Factor A, Pathology, medicine.medical_specialty, Biopsy, medicine.medical_treatment, Protein Serine-Threonine Kinases, Lesion, Immunocompromised Host, chemistry.chemical_compound, Proto-Oncogene Proteins, medicine, Humans, Phosphorylation, Sarcoma, Kaposi, Kaposi's sarcoma, Skin, Antibacterial agent, Sirolimus, Antibiotics, Antineoplastic, medicine.diagnostic_test, business.industry, Ribosomal Protein S6 Kinases, 70-kDa, General Medicine, Middle Aged, medicine.disease, Kidney Transplantation, Vascular Endothelial Growth Factor Receptor-2, Vascular endothelial growth factor, surgical procedures, operative, Immunosuppressive drug, chemistry, cardiovascular system, Female, Sarcoma, medicine.symptom, business, Proto-Oncogene Proteins c-akt, Immunosuppressive Agents, Signal Transduction, medicine.drug
Abstract

Recipients of organ transplants are susceptible to Kaposi's sarcoma as a result of treatment with immunosuppressive drugs. Sirolimus (rapamycin), an immunosuppressive drug, may also have antitumor effects.We stopped cyclosporine therapy in 15 kidney-transplant recipients who had biopsy-proven Kaposi's sarcoma and began sirolimus therapy. All patients underwent an excisional biopsy of the lesion and one biopsy of normal skin at the time of diagnosis. A second biopsy was performed at the site of a previous Kaposi's sarcoma lesion six months after sirolimus therapy was begun. We examined biopsy specimens for vascular endothelial growth factor (VEGF), Flk-1/KDR protein, and phosphorylated Akt and p70S6 kinase, two enzymes in the signaling pathway targeted by sirolimus.Three months after sirolimus therapy was begun, all cutaneous Kaposi's sarcoma lesions had disappeared in all patients. Remission was confirmed histologically in all patients six months after sirolimus therapy was begun. There were no acute episodes of rejection or changes in kidney-graft function. Levels of Flk-1/KDR and phosphorylated Akt and p70S6 kinase were increased in Kaposi's sarcoma cells. The expression of VEGF was increased in Kaposi's sarcoma cells and even more so in normal skin cells around the Kaposi's sarcoma lesions.Sirolimus inhibits the progression of dermal Kaposi's sarcoma in kidney-transplant recipients while providing effective immunosuppression.

Published
2005

27. Taking Care of Relationships in the Intensive Care Unit: Positive Impact on Family Consent for Organ Donation

Author

Bocci, M. G, D'Alo', Ciro, Barelli, Roberta, Inguscio, Simona, Prestifilippo, Alessia, Di Paolo, S, Lochi, S, Fanfarillo, M, Grieco, D. L, Maviglia, Riccardo, Caricato, Anselmo, Mistraletti, G, Pulitano', Silvia Maria, Antonelli, Massimo, Sandroni, Claudio, D'Alo', Ciro (ORCID:0000-0003-2868-0928), Caricato, Anselmo (ORCID:0000-0001-5929-120X), Pulitano', Silvia Maria Modesta (ORCID:0000-0002-8496-379X), Antonelli, M (ORCID:0000-0003-3007-1670), Sandroni, Claudio (ORCID:0000-0002-8878-2611), Bocci, M. G, D'Alo', Ciro, Barelli, Roberta, Inguscio, Simona, Prestifilippo, Alessia, Di Paolo, S, Lochi, S, Fanfarillo, M, Grieco, D. L, Maviglia, Riccardo, Caricato, Anselmo, Mistraletti, G, Pulitano', Silvia Maria, Antonelli, Massimo, Sandroni, Claudio, D'Alo', Ciro (ORCID:0000-0003-2868-0928), Caricato, Anselmo (ORCID:0000-0001-5929-120X), Pulitano', Silvia Maria Modesta (ORCID:0000-0002-8496-379X), Antonelli, M (ORCID:0000-0003-3007-1670), and Sandroni, Claudio (ORCID:0000-0002-8878-2611)

Abstract

Background Organ donation refusal from relatives of potential donors with brain death significantly reduces organ availability. The need for organ donation has increased over time, but the shortage of available donors is the major limiting factor in transplantation. We analyzed the impact of a new systematic communication approach between medical staff and patients' relatives on the rate of consent to organ donation. Methods The study was conducted as a single-center, non-randomized, controlled, before-and-after study at an 18-bed intensive care unit (ICU) of a university hospital. We compared the rate of consent for organ donation before and after the introduction of the new communication approach. Results A total of 291 brain-dead patients were studied. The consent rate increased from 71% in the pre-intervention period (2007–2012) to 78.4% in the post-intervention period (2013–2015), with an 82.75% increase in the 2014 to 2015 period. During these periods, no significant variation of consent to organ donation was recorded at the national and regional levels. Conclusions The introduction of a new communication approach between medical staff and relatives of brain-dead patients was associated with a significant increase in the rate of consent to donation. Our results highlight the importance of empathy with relatives in the ICU. The need for organ transplants has increased over recent decades; nevertheless, the number of donors is insufficient [1]. The major factor limiting the number of donations from brain-dead potential donors is the low rate of consent from their families [2], [3], [4] and [5].

Published
2016

29. The Historiography of the Concept of 'Workshop' in Ancient Near Eastern Archaeology: Descriptive Models and Theoretical Approaches (Anthropology vs. Art History)

Author

Di Paolo S.

Subjects
workshop, approcci metodologici, archeologia, storia dell'arte
Abstract

Through a historiographic analysis, this contribution surveys the different hypotheses that have been formulated in archaeology and art history: this double focus allows for moving between different scales of analysis ranging from the concept of household production to regionally based production. In particular, in art history, traditional approaches concerning "artistic attribution" or "authorship" have been partially replaced by a new perspective, according to which the intrinsic meaning and content of artworks are now considered the most relevant thread of inquiry.

Published
2014

33. Changing Space, Time and Meaning: The Seal of Yaqaru from Ugarit: A Reconversion?

Author

Di Paolo S.

Subjects
ideologia, arte, glittica, siria
Abstract

Saggio in cui si riesamina un'impronta di sigillo su tavoletta del Bronzo Tardo scoperta a Ugarit negli anni '50. L'iscrizione e la scena raffigurata fanno presumere si tratti di un sigillo più antico forse fatto incidere da un funzionario regale, sulla base dei confronti con simili oggetti della Mesopotamia meridionale.

Published
2013

36. Cultured Human Mesangial Cells Produce both Type 1 and Type 2 Plasminogen Activator Inhibitors

Author

Di Paolo S, Loreto Gesualdo, L.G. Cavallo, Mascolo E, Francesco Paolo Schena, Mario Colucci, Pasqualina Montemurro, Massimo Conese, Nicola Semeraro, and Elena Ranieri

Subjects
Mesangial cell, Activator (genetics), Fibrinolysis, Enzyme-Linked Immunosorbent Assay, Hematology, Biology, Blotting, Northern, Molecular biology, Glomerular Mesangium, chemistry.chemical_compound, Antigen, chemistry, Biochemistry, Evaluation Studies as Topic, Cell culture, Polyclonal antibodies, Plasminogen activator inhibitor-1, Plasminogen Activator Inhibitor 1, Plasminogen activator inhibitor-2, Plasminogen Activator Inhibitor 2, biology.protein, Humans, Plasminogen activator, Cells, Cultured
Abstract

SummaryCultured human mesangial cells (HMC) derived from normal kidneys have been shown to synthesize tissue-type plasminogen activator (t-PA) and excess amounts of PA inhibitor type 1 (PAI-1). Conflicting results have been obtained concerning the production of urokinase-type PA (u-PA) and efforts to show PA inhibitor 2 (PAI-2) met with failure. We evaluated the fibrinolytic profile of cultured HMC lines obtained from 12 patients with renal carcinoma and one cadaveric kidney donor. Subconfluent cells (third passage) were incubated overnight in serum-free medium. t-PA, u-PA, PAI-1 and PAI-2 antigens were assayed by ELISA methods and PA and PAI activities by amidolytic methods both in conditioned medium (CM) and cell extracts (CE). Besides PAI-1, PAI-2 antigen was detected in all but one HMC lines. At variance with the former, which was largely released in the culture medium, PAI-2 was mainly cell-associated. t-PA antigen was found in all but two cell lines while u-PA antigen was detected in relatively high concentrations in 8 cell lines. PA activity, identified as u-PA by functional and immunological criteria, was measured in CM of six of the eight u-PA producing cell lines, whereas PAI activity was undetectable or very low in CM of all cell lines, suggesting that PAI-1 was largely inactive. Functional assays of cell extracts demonstrated the presence of PA activity, again identified as u-PA, only in samples (five lines) containing u-PA antigen in excess over PAI-2. PAI activity was found instead in the extracts in which the inhibitor was higher than the activator (six lines) and was identified as PAI-2, as it inhibited u-PA but not single-chain t-PA and was neutralized by a polyclonal anti-PAI-2 antibody. The heterogeneous fibrinolytic pattern of HMC lines was confirmed by mRNA analysis of three representative lines. Results were similar when HMC lines at passage five were used, except that the u-PA content was significantly reduced both in CM and CE. These findings indicate that the fibrinolytic profile of cultured HMC is more complex than previously reported. The production of large amounts of PAI-2 may represent an additional control mechanism of proteinase activity.

Published
1995

40. From Italy to Cyprus and Back Again. Old Researches and Ongoing Projects

Author

Di Paolo S.

Subjects
italia, archeologia, cipro
Abstract

Il volume è stato pubblicato in concomitanza con il semestre di Presidenza dell'Unione Europea da parte di Cipro. L'articolo è una lunga e critica riflessione sui progetti archeologici italiani riguardanti l'antica civiltà cipriota.

Published
2012

42. Deadwood in forest stands close to old-growthness under Mediterranean conditions in the Italian Peninsula

Author

Lombardi, F., Chirici, G., Marco Marchetti, Roberto Tognetti, Bruno Lasserre, Corona, P., Barbati, A., Ferrari, B., Di Paolo, S., Giuliarelli, D., Mason, F., Iovino, F., Nicolaci, A., Bianchi, L., and Maltoni, A. Travaglini D.

Subjects
forest inventory, unharvested Mediterranean forests, Italy, sustainable forest management
Abstract

Considering that indicators of old-growth features can vary across the European ecoregions, this paper provides some results to identify the distinctive traits of old-growth forests in the Mediterranean ecoregion. Deadwood occurrence as indicator of naturalness is investigated in some remote forest areas that have developed in absence of anthropogenic disturbance over the past few decades. Eleven study sites across the Italian peninsula were elected and records of deadwood were carried out in 1-ha size plots. Deadwood volume, deadwood types and decay stages were inventoried in the selected sites. The amounts of deadwood indicate a large variability among the investigated forest stands: the total volume ranged between 2 and 143 m3ha-1, with an average of 60 m3ha-1. Lying deadwood is the most abundant component of deadwood in the investigated forests, due to the natural mortality occurring in the stands in relation to the processes established in the last decades. On the contrary, stumps are the less represented type of deadwood in almost all the study areas. All the decay classes are present in each study site. The amount of deadwood in Southern Europe, even if lower than that reported for North and Central European countries, could have a different meaning due to the faster decay occurring in Mediterranean forest ecosystems. For this reason, old-growth features and the characteristics of each indicator should be framed and referred to well-defined climatic and biogeographic contexts. Distinctively, under the conditions here investigated, three main deadwood features prove to characterize forest stands close to old-growthness: a ratio of dead to living wood not lower than 10%; lying deadwood much more abundant than the standing one; large range of deadwood size and decay classes across all the deadwood components.

Published
2010

44. Continuità e discontinuità tra Ur III e paleobabilonese iniziale: un contributo sulla cronologia dallo studio delle Udienze Reali sui sigilli dei 'servi del re'

Author

Di Paolo S.

Subjects
glyptic art, Babylonia, administration
Abstract

The Royal Audience is adopted during the Ur III period when it becomes a special imagery whcih is linked to the administrative re-organization of the reign. In this period the Royal Audience is used by most important state officials. This particular iconography and a royal/personal inscription represent the figurative message of the political and ideological program of the Ur III kings. But also during the Early Old Babylonian phase (especially in the 20th and 19th centuries BC) it is attested on the glyptic art of central and southern Babylonia.

Published
2010

48. What Production Model can be Deduced for First-Millenium BC Syro-Palestinian Ivories? Some Observations, with Analogies Drawn from Byzantine, Early Medieval and Gothic Material

Author

Di Paolo S.

Subjects
ivories, workshops, near east
Abstract

What is known about artisan production methods in the Ancient Near East? The problem of production in the history of the studies on Syro-Palestinian ivories: perhaps a question that has been avoided. Criticism of theconcepts of school and workshop (from taxonomy to semantics). Remarks on the production system

Published
2009

50. Dalle straordinarie avventure di Lady Hesther Stanhope alla'crociata' archeologica di Butler: la politica 'religiosa' dei viaggi e delle esplorazioni scientifiche nella regione di Damasco tra XIX e XX secolo

Author

Di Paolo S.

Subjects
Syria, archaeology, travels
Abstract

The first historical and archaeological interest of the European and North-American travellers froDamascus region and all Souther Syria has, not only, scientific purposes. Their travels or explorations have, above all, religious reasons owing to the geographical position of this region, between the Lebanese coast and the Northern border of the Palestine. All these facts influenced the methods of research and the archaeological activity in this area. Some interesting data concern also the discovery of bronze Age sites: before the field trips of Albright some ancient tell have been visited adn described from travellers and diplomats.

Published
2008

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