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20 results on '"Di Paolo, Mattia"'

4. A Window to the Brain: The Retina to Monitor the Progression and Efficacy of Saffron Repron ® Pre-Treatment in an LPS Model of Neuroinflammation and Memory Impairment.

Author

Di Paolo, Mattia, Corsi, Francesca, Cerri, Chiara, Bisti, Silvia, Piano, Ilaria, and Gargini, Claudia

Subjects
*MEMORY disorders, *RETINA, *VISION, *ALZHEIMER'S disease, *SAFFRON crocus, *NEUROINFLAMMATION
Abstract

A mechanism shared by most neurodegenerative diseases, like Alzheimer's disease (AD) and Parkinson's disease (PD), is neuroinflammation. It has been shown to have a link between cognitive impairment and retinal function under neuroinflammatory conditions, confirming the essential role of the retina as a window to the brain. Here, we characterize a mouse model of LPS-induced neuroinflammation describing the parallel deterioration of both memory and visual function. Then, we demonstrate, using the Novel Object Recognition test (NOR) and electroretinogram (ERG) recordings, that preventive, chronic treatment with saffron Repron® is able to reduce the neuroinflammation process and prevent the impairment of both cognitive and visual function. The improvement in behavioral and visual function is confirmed by the pattern of expression of neuroinflammation-related genes and related proteins where pre-treatment with Repron® saffron presents a positive modulation compared with that obtained in animals treated with LPS alone. These results hold for retinal tissue and partially in the brain, where it appears that the onset of damage was delayed. This trend underlines the critical role of the retina as a most sensitive portion of the central nervous system to LPS-induced damage and could be used as a "sensor" for the early detection of neurodegenerative diseases such as Alzheimer's. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Biocompatibility of a Conjugated Polymer Retinal Prosthesis in the Domestic Pig

Author

Maya-Vetencourt, José Fernando, primary, Di Marco, Stefano, additional, Mete, Maurizio, additional, Di Paolo, Mattia, additional, Ventrella, Domenico, additional, Barone, Francesca, additional, Elmi, Alberto, additional, Manfredi, Giovanni, additional, Desii, Andrea, additional, Sannita, Walter G., additional, Bisti, Silvia, additional, Lanzani, Guglielmo, additional, Pertile, Grazia, additional, Bacci, Maria Laura, additional, and Benfenati, Fabio, additional

Published
2020
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12. Fluorescent light induces neurodegeneration in the rodent nigrostriatal system but near infrared LED light does not

Author

Romeo, Stefania, primary, Vitale, Flora, additional, Viaggi, Cristina, additional, di Marco, Stefano, additional, Aloisi, Gabriella, additional, Fasciani, Irene, additional, Pardini, Carla, additional, Pietrantoni, Ilaria, additional, Di Paolo, Mattia, additional, Riccitelli, Serena, additional, Maccarone, Rita, additional, Mattei, Claudia, additional, Capannolo, Marta, additional, Rossi, Mario, additional, Capozzo, Annamaria, additional, Corsini, Giovanni U., additional, Scarnati, Eugenio, additional, Lozzi, Luca, additional, Vaglini, Francesca, additional, and Maggio, Roberto, additional

Published
2017
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13. A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness

Author

Maya-Vetencourt, José Fernando, primary, Ghezzi, Diego, additional, Antognazza, Maria Rosa, additional, Colombo, Elisabetta, additional, Mete, Maurizio, additional, Feyen, Paul, additional, Desii, Andrea, additional, Buschiazzo, Ambra, additional, Di Paolo, Mattia, additional, Di Marco, Stefano, additional, Ticconi, Flavia, additional, Emionite, Laura, additional, Shmal, Dmytro, additional, Marini, Cecilia, additional, Donelli, Ilaria, additional, Freddi, Giuliano, additional, Maccarone, Rita, additional, Bisti, Silvia, additional, Sambuceti, Gianmario, additional, Pertile, Grazia, additional, Lanzani, Guglielmo, additional, and Benfenati, Fabio, additional

Published
2017
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14. Inflammatory and morphological characterization

Author

DI PAOLO, Mattia, Ghezzi, D., Antognazza, M. R., Mete, M., Freddi, G., Donelli, I., Maccarone, Rita, Pertile, G., Lanzani, G., Benfenati, F., and Bisti, Silvia

Published
2015

15. Characterization of a Polymer-Based, Fully Organic Prosthesis for Implantation into the Subretinal Space of the Rat

Author

Antognazza, Maria Rosa, primary, Di Paolo, Mattia, additional, Ghezzi, Diego, additional, Mete, Maurizio, additional, Di Marco, Stefano, additional, Maya-Vetencourt, José Fernando, additional, Maccarone, Rita, additional, Desii, Andrea, additional, Di Fonzo, Fabio, additional, Bramini, Mattia, additional, Russo, Angela, additional, Laudato, Lucia, additional, Donelli, Ilaria, additional, Cilli, Michele, additional, Freddi, Giuliano, additional, Pertile, Grazia, additional, Lanzani, Guglielmo, additional, Bisti, Silvia, additional, and Benfenati, Fabio, additional

Published
2016
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20. Biocompatibility of a Conjugated Polymer Retinal Prosthesis in the Domestic Pig

Author

José Fernando Maya-Vetencourt, Stefano Di Marco, Maurizio Mete, Mattia Di Paolo, Domenico Ventrella, Francesca Barone, Alberto Elmi, Giovanni Manfredi, Andrea Desii, Walter G. Sannita, Silvia Bisti, Guglielmo Lanzani, Grazia Pertile, Maria Laura Bacci, Fabio Benfenati, Maya-Vetencourt, José Fernando, Di Marco, Stefano, Mete, Maurizio, Di Paolo, Mattia, Ventrella, Domenico, Barone, Francesca, Elmi, Alberto, Manfredi, Giovanni, Desii, Andrea, Sannita, Walter G., Bisti, Silvia, Lanzani, Guglielmo, Pertile, Grazia, Bacci, Maria Laura, and Benfenati, Fabio

Subjects
etinal degeneration, retinitis pigmentosa, biomedical pig, retinal prosthesis, conjugated polymers, 0301 basic medicine, Retinal degeneration, Proliferative vitreoretinopathy, Histology, genetic structures, Biocompatibility, lcsh:Biotechnology, retinal prosthesis, Biomedical Engineering, Bioengineering, 02 engineering and technology, 03 medical and health sciences, chemistry.chemical_compound, In vivo, lcsh:TP248.13-248.65, retinitis pigmentosa, Retinitis pigmentosa, medicine, conjugated polymers, Outer nuclear layer, Original Research, Retina, biomedical pig, retinal degeneration, Chemistry, Bioengineering and Biotechnology, Retinal, 021001 nanoscience & nanotechnology, medicine.disease, eye diseases, 030104 developmental biology, medicine.anatomical_structure, sense organs, 0210 nano-technology, Biomedical engineering, Biotechnology
Abstract

The progressive degeneration of retinal photoreceptors is one of the most significant causes of blindness in humans. Conjugated polymers represent an attractive solution to the field of retinal prostheses, and a multi-layer fully organic prosthesis implanted subretinally in dystrophic Royal College of Surgeons (RCS) rats was able to rescue visual functions. As a step toward human translation, we report here the fabrication and in vivo testing of a similar device engineered to adapt to the human-like size of the eye of the domestic pig, an excellent animal paradigm to test therapeutic strategies for photoreceptors degeneration. The active conjugated polymers were layered onto two distinct passive substrates, namely electro-spun silk fibroin (ESF) and polyethylene terephthalate (PET). Naive pigs were implanted subretinally with the active device in one eye, while the contralateral eye was sham implanted with substrate only. Retinal morphology and functionality were assessed before and after surgery by means of in vivo optical coherence tomography and full-field electroretinogram (ff-ERG) analysis. After the sacrifice, the retina morphology and inflammatory markers were analyzed by immunohistochemistry of the excised retinas. Surprisingly, ESF-based prostheses caused a proliferative vitreoretinopathy with disappearance of the ff-ERG b-wave in the implanted eyes. In contrast, PET-based active devices did not evoke significant inflammatory responses. As expected, the subretinal implantation of both PET only and the PET-based prosthesis locally decreased the thickness of the outer nuclear layer due to local photoreceptor loss. However, while the implantation of the PET only substrate decreased the ff-ERG b-wave amplitude with respect to the pre-implant ERG, the eyes implanted with the active device fully preserved the ERG responses, indicating an active compensation of the surgery-induced photoreceptor loss. Our findings highlight the possibility of developing a new generation of conjugated polymer/PET-based prosthetic devices that are highly biocompatible and potentially suitable for subretinal implantation in patients suffering from degenerative blindness.

Published
2020

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