40 results on '"Di Marino, Mp"'
Search Results
2. Poroid hidroadenoma, a case report
- Author
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DELFINO S, TOTO V, BRUNETTI B, DI MARINO MP, PERSICHETTI P., BALDI, Alfonso, Delfino, S, Toto, V, Brunetti, B, DI MARINO, Mp, Baldi, Alfonso, and Persichetti, P.
- Published
- 2007
3. Relationship between cyclooxygenase-2, p21, p27 expression and survival in patients with pleural mesothelioma
- Author
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VICIDOMINI, Giovanni, SANTINI, Mario, Di Marino MP, Baldi F, BALDI, Alfonso, Pastore V., Vicidomini, Giovanni, Santini, Mario, Di Marino, Mp, Baldi, F, Baldi, Alfonso, and Pastore, V.
- Published
- 2004
4. Identification of sentinel lymph node in the surgical treatment of lung cancer
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VICIDOMINI, Giovanni, CUCCURULLO, Vincenzo, BALDI, Alfonso, SANTINI, Mario, Della Vittoria Scarpati M, Di Marino MP, Fiorello A, MANSI, Luigi, Baldi F, Pastore V., Vicidomini, Giovanni, Cuccurullo, Vincenzo, Baldi, Alfonso, Santini, Mario, Della Vittoria Scarpati, M, Di Marino, Mp, Fiorello, A, Mansi, Luigi, Baldi, F, and Pastore, V.
- Published
- 2003
5. La tecnica del linfonodo sentinella nel trattamento chirurgico del cancro polmonare
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DI LIETO, Eugenio, VICIDOMINI, Giovanni, CUCCURULLO, Vincenzo, BALDI, Alfonso, SANTINI, Mario, RAMBALDI PF, DI MARINO MP, MANSI, Luigi, BALDI F, PASTORE V., PASTORE V, DI LIETO, Eugenio, Vicidomini, Giovanni, Cuccurullo, Vincenzo, Baldi, Alfonso, Santini, Mario, Rambaldi, Pf, DI MARINO, Mp, Mansi, Luigi, Baldi, F, and Pastore, V.
- Published
- 2002
6. Congenital cystic adenomatoid malformation of the lung in an adult
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VICIDOMINI, Giovanni, SANTINI, Mario, BALDI, Alfonso, T. CESARANO, F. BALDI, DI MARINO MP, Vicidomini, Giovanni, Santini, Mario, Baldi, Alfonso, T., Cesarano, F., Baldi, and DI MARINO, Mp
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Cystic adenomatoid malformation ,Lung cyst ,Lung abnormalitie - Abstract
Congenital cystic adenomatoid malformation of the lung (CCAM) is characterised by an adenomatoid proliferation of bronchiole-like structures and cysts formation. The condition is most commonty found in newborns and children and it may be associated with other malformations; rarely, the presentation is delayed until adulthood. This paper presents a case of CCAM in a 62-year-old male, who presented with recurrent bacterial pneumonias and breathlessness on exertion. The chest X-rays and CT scan revealed a patchy opacity in the right lower pulmonary zone. Bronchoscopic examination was normal. At surgery, a mass involving the right lower and middle lobes, and enlargement of hilar lymph nodes were found. A bilobectomy was performed without complications. Examination of the gross specimen showed a lesion characterised by multiple small cysts, all less than 1 cm in diameter; they were lined predominately by columnar epithelium, occasionally by ciliated epithelium. Rare cysts were lined by foreign body giant cells. Elastic fibers and smooth muscle were present within the cysts wall. Peripherally, there were normal alveoli and bronchioli mixed with cysts, and plasma-lymphocitic infiltrates. The final diagnosis was Stocker's Type II CCAM of the lung. CCAM of the lung is a rare developmental lesion of the lung and it has no sexual predilection. It is usually unilateral and sublobar or lobar in size, but occasionally it can be multilobar. Typical histologic feature of CCAM are adenomatoid proliferation of bronchiole-like structures and macro- or microcysts lined by columnar or cuboidal epithelium and absence of cartilage and bronchial glands. Inflammatory changes are not found in infants, but may be present in adult patients. Based on the size of the cysts, CCAM may be classified into three different types: type I characterised by multiple cysts, over than 1 cm in diameter; type II with smaller cysts, less than 1 cm in diameter; type III that shows solid lesions composed of bronchiole-like structures. Type II is commonly found in childhood, but is occasionally seen in adult patients, as that one in our report. The insult probably occurs between 4th and 7th week of fetal life. The etiologic agent is unknown. The histologic diagnosis of CCAM is difficult in adult patient, perhaps because of supervening infections that sometimes distort the underlying diagnostic pathologic appearances and make them difficult to recognise, as happened in our case. From the clinical point of view, most of the lesions cause severe respiratory failure; in adult individuals the diagnosis is difficult, since there are very few relevant symptoms and signs. The patients can present with fever, recurrent infections, breathlessness and haemoptysis. The chest X-rays abnormalities are not specific and include homogeneous or multicystic opacities. Similarly, other diagnostic methods add no further useful informations. Surgical treatment is necessary also in adult patients, because of the risk of recurrent pulmonary infections and malignancies associated with CCAM. Lobectomy is the treatment of choice, but sometimes a larger resection is required, when the lesion involves more than one lobe. Congenital cystic adenomatoid malformation of the lung (CCAM) is characterised by an adenomatoid proliferation of bronchiole-like structures and cysts formation. The condition is most commonty found in newborns and children and it may be associated with other malformations; rarely, the presentation is delayed until adulthood. This paper presents a case of CCAM in a 62-year-old male, who presented with recurrent bacterial pneumonias and breathlessness on exertion. The chest X-rays and CT scan revealed a patchy opacity in the right lower pulmonary zone. Bronchoscopic examination was normal. At surgery, a mass involving the right lower and middle lobes, and enlargement of hilar lymph nodes were found. A bilobectomy was performed without complications. Examination of the gross specimen showed a lesion characterised by multiple small cysts, all less than 1 cm in diameter; they were lined predominately by columnar epithelium, occasionally by ciliated epithelium. Rare cysts were lined by foreign body giant cells. Elastic fibers and smooth muscle were present within the cysts wall. Peripherally, there were normal alveoli and bronchioli mixed with cysts, and plasma-lymphocitic infiltrates. The final diagnosis was Stocker's Type II CCAM of the lung. CCAM of the lung is a rare developmental lesion of the lung and it has no sexual predilection. It is usually unilateral and sublobar or lobar in size, but occasionally it can be multilobar. Typical histologic feature of CCAM are adenomatoid proliferation of bronchiole-like structures and macro- or microcysts lined by columnar or cuboidal epithelium and absence of cartilage and bronchial glands. Inflammatory changes are not found in infants, but may be present in adult patients. Based on the size of the cysts, CCAM may be classified into three different types: type I characterised by multiple cysts, over than 1 cm in diameter; type II with smaller cysts, less than 1 cm in diameter; type III that shows solid lesions composed of bronchiole-like structures. Type II is commonly found in childhood, but is occasionally seen in adult patients, as that one in our report. The insult probably occurs between 4th and 7th week of fetal life. The etiologic agent is unknown. The histologic diagnosis of CCAM is difficult in adult patient, perhaps because of supervening infections that sometimes distort the underlying diagnostic pathologic appearances and make them difficult to recognise, as happened in our case. From the clinical point of view, most of the lesions cause severe respiratory failure; in adult individuals the diagnosis is difficult, since there are very few relevant symptoms and signs. The patients can present with fever, recurrent infections, breathlessness and haemoptysis. The chest X-rays abnormalities are not specific and include homogeneous or multicystic opacities. Similarly, other diagnostic methods add no further useful informations. Surgical treatment is necessary also in adult patients, because of the risk of recurrent pulmonary infections and malignancies associated with CCAM. Lobectomy is the treatment of choice, but sometimes a larger resection is required, when the lesion involves more than one lobe.
- Published
- 1997
7. CASE OF THE SEASON - ADULT PULMONARY BLASTOMA
- Author
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DI LIETO, Eugenio, BALDI, Alfonso, VICIDOMINI, Giovanni, DI MARINO MP, BALDI F., DI LIETO, Eugenio, Baldi, Alfonso, Vicidomini, Giovanni, DI MARINO, Mp, and Baldi, F.
- Subjects
Pulmonary blastoma - Abstract
Pulmonary blastoma is a rare tumor of the lung consisting of immature mesenchyma and epithelial structures that can mimic the structure of the embryonic lung. In this article, we report a case of pulmonary blastoma occurred in an adult individual. We review the literature concerning this rare neoplasm that includes less than one hundred cases reported. We also describe the pathologic features of this disease which is microscopically divided in two classes: 1) lesions composed solely of malignant gland of embryonic appearance (WDFA: Well-Differentiated Fetal Adenocarcinomas), and 2) lesions with biphasic appearance, containing both neoplastic glands and either adult sarcomatous or embryonic mesenchyme. The adult pulmonary blastomas are considered as an entity distinct from chidhood blastomas. This condition may be frequently asymptomatic; if symptomatic, it shows the same clinical picture of a mass in the lung impinging on bronchi or pleura; the most usual symptoms include cough, hemoptysis, and chest pain. Chest radiography typically shows a peripheral or central lung opacity without preference for any lobe. The prognosis is poor, due to the high incidence of metastasis. Histologic class and clinical findings can be of prognostic value in pulmonary blastoma. We believe that an early diagnosis is essential: in our case, this allowed a complete resection of the tumor and the patient is still alive without recurrence 3 years after the surgical treatment. Pulmonary blastoma is a rare tumor of the lung consisting of immature mesenchyma and epithelial structures that can mimic the structure of the embryonic lung. In this article, we report a case of pulmonary blastoma occurred in an adult individual. We review the literature concerning this rare neoplasm that includes less than one hundred cases reported. We also describe the pathologic features of this disease which is microscopically divided in two classes: 1) lesions composed solely of malignant gland of embryonic appearance (WDFA: Well-Differentiated Fetal Adenocarcinomas), and 2) lesions with biphasic appearance, containing both neoplastic glands and either adult sarcomatous or embryonic mesenchyme. The adult pulmonary blastomas are considered as an entity distinct from chidhood blastomas. This condition may be frequently asymptomatic; if symptomatic, it shows the same clinical picture of a mass in the lung impinging on bronchi or pleura; the most usual symptoms include cough, hemoptysis, and chest pain. Chest radiography typically shows a peripheral or central lung opacity without preference for any lobe. The prognosis is poor, due to the high incidence of metastasis. Histologic class and clinical findings can be of prognostic value in pulmonary blastoma. We believe that an early diagnosis is essential: in our case, this allowed a complete resection of the tumor and the patient is still alive without recurrence 3 years after the surgical treatment.
- Published
- 1995
8. Surviving acute myocardial infarction: survivin expression in viable cardiomyoctes after infarction
- Author
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Santini, D, Abbate, Antonio, Scarpa, S, Vasaturo, F, Biondi Zoccai, Giuseppe, Bussani, Rossana, De Giorgio, Fabio, Bassan, F, Camilot, D, Di Marino, Mp, Feroce, F, Baldi, F, Silvestri, Furio, Crea, Filippo, and Baldi, A.
- Subjects
Surviving ,acute myocardial infarction ,Settore MED/43 - MEDICINA LEGALE - Published
- 2004
9. Expression of p21 in SV40 large T antigen positive human pleural mesothelioma: relationship with survival
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Bruno Vincenzi, Raffaele Rossiello, A M Groeger, Feliciano Baldi, Giuseppe Tonini, V. Esposito, M P Di Marino, Mario Santini, Roberto Cassandro, Alfonso Baldi, Anna Angelini, Tullio Battista, Marco G. Paggi, Baldi, Alfonso, Groeger, Am, Esposito, V, Cassandro, R, Tonini, G, Battista, T, DI MARINO, Mp, Vincenzi, B, Santini, Mario, Angelini, A, Rossiello, Raffaele, Baldi, F, and Paggi, Mg
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Cyclin-Dependent Kinase Inhibitor p21 ,Mesothelioma ,Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,Pleural Neoplasms ,T-Lymphocytes ,Simian virus 40 ,Malignancy ,medicine.disease_cause ,Pathogenesis ,Pleural disease ,Cyclins ,medicine ,Humans ,Pleural Neoplasm ,Antigens, Viral ,neoplasms ,Survival analysis ,business.industry ,Respiratory disease ,respiratory system ,medicine.disease ,Immunohistochemistry ,Survival Analysis ,respiratory tract diseases ,Cancer research ,Original Article ,Carcinogenesis ,business - Abstract
Background: Mesothelioma is the most commonly occurring primary pleural neoplasm. Several studies have documented an increase in the incidence of this malignancy during the last decades. Although the association between asbestos exposure and development of mesothelioma is generally accepted, the exact mechanism of carcinogenesis is unknown. Recently, Simian virus 40 large T antigen (SV40 Tag) expression has been detected in pleural mesothelioma. The ability of SV40 oncoproteins to inactivate p53 and retinoblastoma tumour suppressor proteins has been proposed as an important step in the pathogenesis of human mesothelioma. Methods: To obtain a better understanding of the molecular mechanisms of the pathogenesis of mesothelioma, the expression of the cell cycle inhibitor p21WAF1/CIP1 (p21), a downstream target of p53, was evaluated immunohistochemically in a group of 29 mesothelioma specimens already characterised for the presence of SV40 Tag sequences. Results: Statistical analysis did not reveal any correlation between p21 expression and histopathological type of mesothelioma using the κ2 test (p=0.577). A significant positive relationship was found between p21 expression level and the patients' overall survival according to the Kaplan-Meier survival curves and using a log rank test (median difference in survival 7 months, 95% CI 4.8 to 9.9; p
- Published
- 2002
10. Non-alcoholic fatty liver disease in an area of southern Italy: main clinical, histological, and pathophysiological aspects
- Author
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Vincenzo De Girolamo, Camillo Del Vecchio Blanco, Veronica Verde, Luigi Terracciano, Maria Marino, Concetta Tuccillo, Raffaella Vecchione, Filomena Morisco, Antonio Ascione, F.P. Picciotto, Carmela Loguercio, L. Cimino, Gabriele Budillon, Feliciano Baldi, Antonio Di Carlo, Ilario de Sio, Loguercio, Carmelina, DE GIROLAMO, V, DE SIO, I, Tuccillo, C, Ascione, A, Baldi, F, Budillon, G, Cimino, L, DI CARLO, A, DI MARINO, Mp, Morisco, F, Picciotto, F, Terracciano, L, Vecchione, R, Verde, V, DEL VECCHIO BLANCO, C., Loguercio, C, Budillon, Gabriele, and Morisco, Filomena
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Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,Cirrhosis ,Adolescent ,Alcohol Drinking ,Iron ,Chronic liver disease ,Gastroenterology ,Body Mass Index ,Diabetes mellitus genetics ,Malondialdehyde ,Internal medicine ,Insulin Secretion ,Diabetes Mellitus ,medicine ,Hyperinsulinemia ,Humans ,Insulin ,Aspartate Aminotransferases ,Triglycerides ,Aged ,Sex Characteristics ,Hepatology ,medicine.diagnostic_test ,business.industry ,Liver Diseases ,Fatty liver ,nutritional and metabolic diseases ,Alanine Transaminase ,Middle Aged ,Alkaline Phosphatase ,medicine.disease ,Fatty Liver ,Cholesterol ,Endocrinology ,Italy ,Liver biopsy ,Female ,Steatohepatitis ,Energy Intake ,business ,Dyslipidemia - Abstract
Background/Aims : Studies on non-alcoholic fatty liver disease (NAFLD) have included chronic liver damage attributed to various causes. Our investigation was held to observe the main clinical, histological, and pathophysiological aspects of NAFLD in patients not exposed to any known cause of chronic liver disease. Methods : We evaluated, in 84 in-patients (male/female, 66/18; median age, 36 years), the clinical and biochemical characteristics of NAFLD, and particularly its association with diabetes, dyslipidemia, hyperinsulinemia and/or with the increase of parameters of oxidative stress (blood levels of malonyldialdehyde, 4-hydroxynonenal and total plasma antioxidant capacity). Results : Ninety percent of patients had an increased body mass index (BMI), 35% had dyslipidemia, 40% had sub-clinical diabetes (only 3% had overt diabetes), 60% had hyperinsulinemia, and more than 90% had enhanced levels of lipid peroxidation markers. In 48 patients who had consented to liver biopsy, we found: 14 with simple steatosis, 32 with steatohepatitis, and two with cirrhosis. Conclusions : Our data indicate that in our country, NAFLD may occur in young males with an increased BMI, with or without hyperinsulinemia, dyslipidemia and diabetes, generally associated with disorders of redox status, and that it may be differentiated from steatosis to steatohepatitis or cirrhosis only with a liver biopsy.
- Published
- 2001
11. The serine protease HtrA1 is a novel prognostic factor for human mesothelioma
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Pasquale Mellone, Alfonso Baldi, Simona Menegozzo, Mario Santini, Gennaro Citro, M. Marino, Alessandra Mirri, Bruno Vincenzi, Marcella Mottolese, Anna Ceribelli, Mara Campioni, Jeremy Chien, Francesco Facciolo, Viji Shridhar, P. Visca, Enrico P. Spugnini, Vincenzo Giuseppe Di Crescenzo, Michael Ehrmann, Baldi, Alfonso, Mottolese, M, Vincenzi, B, Campioni, M, Mellone, P, DI MARINO, Mp, DI CRESCENZO, V, Visca, P, Menegozzo, S, Citro, G, Cerebelli, A, Mirri, A, Chien, J, Shridhar, V, Ehrmann, M, Santini, Mario, and Facciolo, F.
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Male ,Mesothelioma ,Oncology ,medicine.medical_specialty ,Multivariate analysis ,Survival ,Prognosi ,EGFR ,Biology ,Bioinformatics ,Cell Line, Tumor ,Internal medicine ,Biomarkers, Tumor ,Genetics ,medicine ,Humans ,Aged ,Retrospective Studies ,Aged, 80 and over ,Pharmacology ,Serine protease ,Proportional hazards model ,Serine Endopeptidases ,Serine Protease HTRA1 ,High-Temperature Requirement A Serine Peptidase 1 ,Middle Aged ,Prognosis ,medicine.disease ,Immunohistochemistry ,eye diseases ,ErbB Receptors ,HtrA1 ,HTRA1 ,biology.protein ,Molecular Medicine ,Female ,Lymph ,Follow-Up Studies - Abstract
Aims: The objective of our study was to analyze the potential prognostic value of the expression of the serine protease HtrA1 and of EGFR in 70 malignant mesotheliomas. Materials & methods: Immunohistochemistry was used to determine the expression of HtrA1 and EGFR. Univariate and multivariate analyses were used to correlate expression of these molecular factors in combination with available clinicopathologic data to patient survival. Results: A positive, statistically significant relationship has been recorded between HtrA1 expression level and survival (p
- Published
- 2008
12. Right ventricular dilatation after left ventricular acute myocardial infarction is predictive of extremely high peri-infarctual apoptosis at postmortem examination in humans
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Bussani, Rossana, Abbate, A., Biondi Zoccai, G. G. L., Dobrina, Aldo, Leone, A. M., Camilot, D., Di Marino, M. P., Silvestri, Furio, Baldi, F., Biasucci, L. M., Baldi, A., Cova, MARIA ASSUNTA, Bussani, Rossana, Abbate, A., Biondi Zoccai, G. G. L., Dobrina, Aldo, Leone, A. M., Camilot, D., Di Marino, M. P., Silvestri, Furio, Baldi, F., Biasucci, L. M., Baldi, A., Cova, MARIA ASSUNTA, Bussani, R, Abbate, A, BIONDI ZOCCAI, Gg, Dobrina, A, Leone, Am, Camilot, D, DI MARINO, Mp, Baldi, F, Silvestri, F, Biasucci, Lm, and Baldi, Alfonso
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Male ,medicine.medical_specialty ,Peri ,Myocardial Infarction ,Infarction ,Apoptosis ,Autopsy ,Statistics, Nonparametric ,Pathology and Forensic Medicine ,Internal medicine ,Occlusion ,medicine ,Humans ,cardiovascular diseases ,Myocardial infarction ,Ventricular remodeling ,Pathological ,Aged ,Analysis of Variance ,Ventricular Remodeling ,business.industry ,Myocardium ,Coronary Stenosis ,cardiac remodelling ,Original Articles ,General Medicine ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Ventricle ,cardiovascular system ,Cardiology ,Female ,business - Abstract
Background: Cardiac remodelling after acute myocardial infarction (AMI) is characterised by molecular and cellular mechanisms involving both left and right ventricles, and biventricular failure identifies patients with an extremely unfavourable prognosis. Aims: To assess whether a link exists between increased myocardial apoptotic rates (AR) at sites of recent infarction and patterns of unfavourable cardiac remodelling, such as biventricular enlargement after left ventricular (LV) infarction. Methods: Twelve patients with recent AMI involving the LV and not the right ventricle (RV) and with permanent infarct related artery occlusion were selected at necropsy. Gross pathological characteristics, such as LV and RV dilatation, and AR at site of infarction were assessed. Potential false positive results (DNA synthesis and RNA splicing) were excluded from the cell count. Results: RV enlargement, defined as a tricuspidal ring greater than 120 mm, was found in five cases and was associated with LV dilatation. These patients showed significantly higher AR than the others. When the subjects were divided into three groups according to progressive cardiac remodelling (absence of cardiac dilatation, isolated LV dilatation, and biventricular enlargement), the last group had significantly higher ARs than the other two groups, showing that myocardiocyte apoptosis is increased in more unfavourable forms of cardiac remodelling. Conclusion: Patients with severely unfavourable cardiac remodelling, such as biventricular enlargement, have extremely high myocardiocyte apoptosis at necropsy, even late after LV myocardial infarction, supporting the role of myocardiocyte loss in determining post-infarction adverse remodelling.
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- 2003
13. Solitary muscle metastasis from lung carcinoma
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Santini, M., Vicidomini, G., Di Marino, M. P., Alfonso Baldi, Santini, Mario, Vicidomini, Giovanni, DI MARINO, Mp, and Baldi, Alfonso
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Muscle secondary neoplasm ,Male ,Leg ,Muscle Neoplasms ,Lung Neoplasms ,Humans ,Antineoplastic Agents ,Carcinoma, Giant Cell ,Cisplatin ,Neoplasm Metastasis ,Lung neoplasms surgery ,Lung surgery ,Aged - Abstract
Recurrence after resection of non-small cell lung carcinoma is generally associated with a poor outcome. Limb muscle metastasis from lung cancer is extremely rare. We present a case of a 71-year-old man who presented with a solitary metastasis to his right lower limb two months after right upper lobectomy for lung cancer (stage: T2N0M0). Twenty-four months after surgical excision and chemotherapy he is alive without signs of neoplastic disease. We believe that a more aggressive approach might be considered for selected patients with solitary extracranial and extra-adrenal metastasis from lung cancer.
- Published
- 2001
14. Drinking habits of subjects with hepatitis C virus-related chronic liver disease: prevalence and effect on clinical, virological and pathological aspects
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Maria Marino, Mauro Di Pierro, D. Disalvo, Alessandro Federico, Feliciano Baldi, Eny Crafa, Concetta Tuccillo, Carmela Loguercio, Camillo Del Vecchio Blanco, Loguercio, Carmelina, DI PIERRO, M, DI MARINO, Mp, Federico, Alessandro, Disalvo, D, Crafa, E, Tuccillo, C, Baldi, F, and DEL VECCHIOBLANCO, C.
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Adult ,Liver Cirrhosis ,Male ,medicine.medical_specialty ,Cirrhosis ,Alcohol Drinking ,medicine.medical_treatment ,Hepatitis C virus ,Temperance ,Hepacivirus ,medicine.disease_cause ,Chronic liver disease ,Gastroenterology ,Antiviral Agents ,Statistics, Nonparametric ,Liver disease ,Fibrosis ,Internal medicine ,medicine ,Humans ,Aged ,Chemotherapy ,business.industry ,General Medicine ,gamma-Glutamyltransferase ,Hepatitis C, Chronic ,Middle Aged ,medicine.disease ,Surgery ,Alcoholism ,Italy ,Toxicity ,Female ,Viral disease ,Interferons ,business ,Biomarkers - Abstract
Alcohol changes the progression of hepatitis C virus (HCV)-related chronic liver disease and may affect the outcome of interferon therapy. The ethanol intake of 245 patients with biopsy-proven chronic hepatitis C with or without cirrhosis, its in teraction with laboratory and histological parameters common to alcohol and HCV-mediated liver damage, and its effects on therapy were evaluated. The results show that 60-70% of subjects regularly consumed alcohol (median intake >40 g/day in about 30%). Less than 50% stopped drinking after being diagnosed as having liver disease. Ethanol intake affected: fibrosis, especially in women, HCV RNA levels, which were significantly lower in abstainers than in drinkers (0.6 ± 0.3 vs 6.9 ± 5.9 Eq/ml x10 6 ; P < 0.01), and response to interferon therapy. The number of responders decreased as ethanol intake increased. There were less abstainers than drinkers am ong non-responders (10.7% vs 63.1% respectively; P < 0.001). Data indicate that alcohol will induce and worsen liver damage and, in subjects with chronic liver disease who continue to drink, adversely affect their response to treatment.
- Published
- 2000
15. Atypical fibroxanthoma with osteoclast-like multinucleated giant cells
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Nicola Ferrara, Baldi, G., Marino, M. P. D. I., Bellucci, G., Baldi, A., Ferrara, Nicola, Baldi, G., Marino, M. P. D. I., Bellucci, G., Baldi, A., Ferrara, N, Baldi, G, DI MARINO, Mp, Bellucci, G, and Baldi, Alfonso
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Aged, 80 and over ,Cell Nucleus ,Male ,Skin Neoplasms ,Histiocytoma, Benign Fibrous ,S100 Proteins ,Osteoclasts ,Histiocytes ,Muscle, Smooth ,Osteoclast-like giant cells tumour ,Immunohistochemistry ,Actins ,Cutaneous fibrous histocytoma ,Atypical fibroxanthoma ,Humans ,Muramidase ,Aged - Abstract
Atypical fibroxanthoma (AF) is generally considered as a low grade superficial variant of fibrohistiocytic neoplasm. In this report we present an unusual variant of this neoplasm arising from actinic damaged skin of an elderly individual. The case was characterized by numerous multinucleated osteoclast-like giant cells uniformly scattered through a pleomorfic cellular proliferation. The osteoclasts giant cell observed represent multinucleated histiocytes rather than true osteoclasts.
- Published
- 2000
16. Neuroendocrine differentiation in non-small cell lung carcinomas
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Baldi, A., Groger, A. M., Esposito, V., Di Marino, M. P., Nicola Ferrara, Baldi, F., Baldi, Alfonso, Groger, Am, Esposito, V, DI MARINO, Mp, Ferrara, N, and Baldi, F.
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Calcitonin ,Serotonin ,Lung Neoplasms ,Vasopressins ,Cell Differentiation ,Immunohistochemistry ,Non-small cell lung carcinoma ,Carcinoma, Neuroendocrine ,CD57 Antigens ,Adrenocorticotropic Hormone ,Neurofilament Proteins ,Carcinoma, Non-Small-Cell Lung ,Phosphopyruvate Hydratase ,Neuroendocrine marker ,Chromogranins ,Chromogranin A ,Humans ,Vimentin ,Bombesin - Abstract
The immunohistochemical expression of ten neuroendocrine and neural differentiation-related antigens in 200 specimens from patients with surgically resected non-small cell lung carcinomas were evaluated. Poorly differentiated adenocarcinomas and undifferentiated large cell carcinomas showed the highest percentage of positive samples (30%-60%) for the markers evaluated with diffuse and intense immunostaining. Poorly differentiated squamous carcinomas bronchioalveolar adenocarcinomas, and giant cell carcinomas showed a lower percentage of positive samples (20%) with moderate immunostaining. Well differentiated tumors were very rarely positive for the neuroendocrine markers. It is concluded that neoplasms positive for the neuroendocrine markers can be considered as non-small cell carcinoma with neuroendocrine features, even if they do not have the histological appearance of neuroendocrine lung neoplasms.
- Published
- 2000
17. Basaloid squamous carcinoma of the tongue. Clinico-anatomical study of a case
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G, Colella, F, Baldi, A, Lanza, M P, Di Marino, G P, Tartaro, Colella, Giuseppe, Baldi, F, Lanza, A, DI MARINO, Mp, and Tartaro, Gianpaolo
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Carcinoma, Transitional Cell ,Humans ,Female ,Aged ,Tongue Neoplasms - Abstract
The basaloid squamous carcinoma was first described in 1986. It is a rare tumor with particular morphologic and biologic features that separate it from the more common squamous cell carcinoma of the head and neck region. A case with histologic diagnosis of basaloid squamous carcinoma of the tongue treated only with radiotherapy, is reported.
- Published
- 1999
18. Cystitis glanduralis complicating an eosinophilic cystitis: A case report
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Baldi A, Mp, Di Marino, Paolo Persichetti, Ferrara N, Baldi F, Baldi, A., Di Marino, M. P., Persichetti, P., Ferrara, Nicola, Baldi, F., Baldi, Alfonso, DI MARINO, Mp, Persichetti, P, and Ferrara, N
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Follow-up ,Histopathology ,Eosinophylic cystiti ,Therapy ,urologic and male genital diseases ,Cystitis glandulari - Abstract
We report on a rare case of cystitis glandularis complicating an eosinophilic cystitis in an adult. Complaints at presentation included dysuria, haematuria and abdominal pain. Ultrasound and cystoscopy suggested a bladder tumor. Histological analysis of bladder biopsy showed the typical findings of cystitis glandularis associated with eosinophilic cystitis. The patient was treated with transurethral resection of the lesion and a combination of corticosteroids and anthistaminics for three months. He is disease-free at 24 months of follow-up.
19. A giant sarcoma of the parotid gland: A case report and review of the literature
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Botev, B., Casale, M., Vincenzi, B., D Ascanio, L., Santini, D., Esposito, V., Di Marino, M. P., Alfonso Baldi, Rinaldi, V., Tonini, G., Salvinelli, F., Botev, B, Casale, M, Vincenzi, B, Dascanio, L, Santini, D, Esposito, V, DI MARINO, Mp, Baldi, Alfonso, Rinaldi, V, Tonini, G, and Salvinelli, F.
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Sarcoma ,Parotid gland - Abstract
Case Report: Primary low-grade fibromyxoid sarcoma (LGFMS) is an extremely rare tumour of the salivary glands and arises from undifferentiated pluripotential mesenchymal cells. We report a case of a huge (17×11×10 cm) primary LGFMS of the parotid gland of a 57-year-old woman. Clinically, a 12×8 cm firm, non-tender, left parotid mass was observed, facial nerve function was not impaired and no enlarged lymph nodules were palpated on the neck. A contrast axial CT scan showed intense enhancement of the enlarged left parotid gland. The fine needle aspiration biopsy (FNAB) was compatible with sarcomatous tissue. The tumour was removed en bloc and the facial nerve was sacrificed; surgical margins were free from disease. Microscopically, the tumour consisted of fibrous and myxoid tissue with varying grades of cellularity and gradual transitions between the two. Post-operative radiotherapy was carried out on the left neck region and parotid turnout bed. Thirty-six months after surgery the patient presents good general conditions without any evidence of local or regional disease. Conclusion: The largest primary LGFMS of the parotid gland described in the literature is reported and a review of the literature on such neoplasms is also provided.
20. Lymphomatoid granulomatosis of the lung: A clinico-pathological study
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Baldi A, Am, Groeger, Esposito V, Di Lieto E, Mp, Di Marino, Santini D, Baldi F, Baldi, Alfonso, Groeger, Am, Esposito, V, DI LIETO, Eugenio, DI MARINO, Mp, Santini, D, and Baldi, F.
- Subjects
B-Lymphocytes ,Lung Neoplasms ,Time Factors ,Lymphomatoid granulomatosi ,T-Lymphocytes ,Lymphomatoid Granulomatosis ,Immunohistochemistry ,Disease-Free Survival ,Lymphocytes, Tumor-Infiltrating ,Antigens, CD ,Chemotherapy, Adjuvant ,Humans ,Cisplatin ,Lung - Abstract
Lymphomatoid granulomatosis is the only form of pulmonary angiitis histologically characterized by a necrotizing angiocentric and angiodestructive lymphoid infiltrate, with an admixed T-cell reaction. We evaluated three patients with a single lung nodule not diagnosed by routine radiological and endoscopic assays. Our investigations showed a prevalence of T-cells in areas of diffuse infiltration, which were actively replacing reactive follicular areas of B-cells, similarly to T-cell lymphomas. Further pathologic assays suggested the histologic diagnosis of grade I lymphomatoid granulomatosis for all three evaluated specimens. After two years, patients treated with a combination of surgical resection and chemotherapy were disease free, supporting the efficacy of aggressive therapy in the management of this often mistreated group of lymphoid proliferations.
21. Pleomorphic adenoma of cervical heterotopic salivary glands
- Author
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Baldi A, Paolo Persichetti, Mp, Di Marino, Nicoletti G, Baldi F, Baldi, Alfonso, Persichetti, P, DI MARINO, Mp, Nicoletti, Giovanni Francesco, and Baldi, F.
- Subjects
Salivary gland ,Adult ,Male ,Heterotopic tissue ,Pleomorphic adenoma ,Adenoma, Pleomorphic ,Humans ,Salivary Gland Neoplasms - Abstract
Neoplastic transformation of heterotopic cervical salivary gland tissue is extremely rare. The Authors describe a case of pleomorphic adenoma arising in this tissue, on the right side of the neck in a 40-year old man. The characteristics of salivary heterotipias of the neck, and their diagnostic difficulties and histogenetic problems are reviewed.
22. Relapsing pneumothorax due to Ascaris lumbricoides larvae
- Author
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Santini, M., Baldi, A., Giovanni VICIDOMINI, Di Marino, M. P., Baldi, F., Santini, Mario, Baldi, Alfonso, Vicidomini, Giovanni, DI MARINO MP, and Baldi, F.
- Subjects
Male ,Ascariasis ,Spontaneons pneumothorax ,Larva ,Ascaris lumbricoide ,Video-assisted thoracic surgery ,Animals ,Humans ,Pneumothorax ,Ascaris lumbricoides ,Child - Abstract
We describe a case of relapsing pneumothorax occurring in a male child aged 11 yrs, resulting from the mechanical inflammatory action of Ascaris lumbricoides larvae localized in the pleuropulmonary tissue. Pulmonary ascariasis should still be considered today in the differential diagnosis of spontaneous pneumothorax occurring in children.
23. A giant sarcoma of the parotid gland: a case report and review of the literature.
- Author
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Botev B, Casale M, Vincenzi B, D'Ascanio L, Santini D, Esposito V, Di Marino MP, Baldi A, Rinaldi V, Tonini G, and Salvinelli F
- Subjects
- Biopsy, Fine-Needle, Female, Humans, Middle Aged, Parotid Gland diagnostic imaging, Parotid Gland surgery, Parotid Neoplasms surgery, Sarcoma surgery, Tomography, X-Ray Computed, Treatment Outcome, Parotid Neoplasms pathology, Sarcoma pathology
- Abstract
Case Report: Primary low-grade fibromyxoid sarcoma (LGFMS) is an extremely rare tumour of the salivary glands and arises from undifferentiated pluripotential mesenchymal cells. We report a case of a huge (17 x ll x 10 cm) primary LGFMS of the parotid gland of a 57-year-old woman. Clinically, a 12x8 cm firm, non-tender, left parotid mass was observed, facial nerve function was not impaired and no enlarged lymph nodules were palpated on the neck. A contrast axial CT scan showed intense enhancement of the enlarged left parotid gland. The fine needle aspiration biopsy (FNAB) was compatible with sarcomatous tissue. The tumour was removed en bloc and the facial nerve was sacrificed; surgical margins were free from disease. Microscopically, the tumour consisted of fibrous and myxoid tissue with varying grades of cellularity and gradual transitions between the two. Post-operative radiotherapy was carried out on the left neck region and parotid tumour bed. Thirty-six months after surgery the patient presents good general conditions without any evidence of local or regional disease., Conclusion: The largest primary LGFMS of the parotid gland described in the literature is reported and a review of the literature on such neoplasms is also provided.
- Published
- 2006
24. Use of an electrothermal bipolar tissue sealing system in lung surgery.
- Author
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Santini M, Vicidomini G, Baldi A, Gallo G, Laperuta P, Busiello L, Di Marino MP, and Pastore V
- Subjects
- Adult, Aged, Animals, Biomechanical Phenomena, Electrocoagulation instrumentation, Female, Hemostasis, Surgical instrumentation, Humans, Male, Middle Aged, Models, Animal, Pulmonary Surgical Procedures instrumentation, Suture Techniques, Swine, Thoracic Surgery, Video-Assisted methods, Thoracotomy methods, Treatment Outcome, Wound Healing, Electrocoagulation methods, Hemostasis, Surgical methods, Lung Diseases surgery, Pulmonary Surgical Procedures methods
- Abstract
Objective: We evaluated the validity of an electrothermal bipolar tissue sealing system (LigaSure, Valleylab Inc., USA) in lung surgery., Methods: Our study was divided into two phases., Experimental: We performed sutures of pulmonary vessels and bronchi and lung wedge resections by LigaSure in 28 lungs of adult pigs; subsequently, we quantitated the sealing capacity of the system detecting the burst pressure for each anatomical structure. Clinical: LigaSure was used in 36 patients undergoing lung surgery. We performed 23 thoracotomic procedures in 16 patients (19 wedge resections, 2 segmentectomies, and 2 fissure separations), and 20 thoracoscopic procedures (13 wedge resections, 5 bullectomies, and 2 adherence dissections)., Experimental: Bronchi and vessels were divided into seven groups (diameter: 1-7 mm); 10 burst pressure measurements for each group were performed. A total of 84 wedge resections were performed; lung specimens were divided into seven groups (weight: 0.2-1.4 g). The percentage of bronchial sutures resistant to the pneumatic critical pressure (60 mmHg) was 100% in the 1-mm and 2-mm groups. No bronchi with 6-mm or 7-mm diameter reached the critical pressure. All pulmonary vessel sutures were resistant to the critical hydrostatic pressure (150 mmHg). The average burst pressure of wedge resection margins was higher than the critical pressure, and the percentage of suture margins resistant to the critical pressure decreased from 95% (0.2-g group) to 68% (1.4-g group). Histology confirmed the sealing of vessels, with a mean depth of thermal injury limited to 1.1mm. Clinical: In all patients, hemostasis obtained by LigaSure was effective, with minimal perioperative bleeding. The mean operating time was 77.2 min (range: 60-97) for thoracotomies and 60.3 min (range: 46-80) for thoracoscopies. The mean drainage duration was 3.1 days (range: 1-8). Two patients had prolonged air leaks (>7 days). The mean postoperative stay was 7.3 days (range: 5-13) for thoracotomies and 4.6 days (range: 1-6) for thoracoscopies., Conclusions: Use of LigaSure in lung surgery appears feasible and easy. It provides satisfactory hemostasis and air-leak prevention; results are comparable to those of stapling devices, but this system seems to have a better benefit/cost ratio. Larger series are needed to confirm these data.
- Published
- 2006
- Full Text
- View/download PDF
25. Surviving acute myocardial infarction: survivin expression in viable cardiomyocytes after infarction.
- Author
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Santini D, Abbate A, Scarpa S, Vasaturo F, Biondi-Zoccai GG, Bussani R, De Giorgio F, Bassan F, Camilot D, Di Marino MP, Feroce F, Baldi F, Silvestri F, Crea F, and Baldi A
- Subjects
- Apoptosis physiology, Cyclooxygenase 2, DNA-Binding Proteins analysis, Humans, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit, Inhibitor of Apoptosis Proteins, Isoenzymes analysis, Membrane Proteins, Myocardial Infarction pathology, Myocardial Ischemia metabolism, Myocardium metabolism, Myocardium pathology, Myocytes, Cardiac metabolism, Myocytes, Cardiac pathology, Neoplasm Proteins, Nuclear Proteins analysis, Prostaglandin-Endoperoxide Synthases analysis, Survivin, Transcription Factors analysis, Cysteine Proteinase Inhibitors analysis, Microtubule-Associated Proteins analysis, Myocardial Infarction metabolism
- Abstract
Background: Apoptosis is a key feature in postinfarction remodelling leading to progressive myocyte loss. Both proapoptotic and antiapoptotic factors contribute to the delicate balance between death and survival. The survivin pathway has emerged as essential in the control of apoptosis, although its role in heart disease is unknown., Aim: To evaluate survivin expression after acute myocardial infarction (AMI)., Methods: Survivin expression was assessed immunohistochemically in the peri-infarct and remote viable myocardium in 17 consecutive patients who died 1-30 weeks after AMI and in four control hearts., Results: Survivin was expressed by myocytes in the peri-infarct area in eight patients and in the remote region in 13 patients. The rate of survivin expression after AMI was significantly higher in the remote versus peri-infarct regions and compared with control hearts. Its expression was inversely associated with the presence of dilated cardiopathy and of apoptosis, independently from the gross pathology infarct size., Conclusions: Survivin myocardial expression after AMI may be associated with the survival of at risk myocardium and may be indicative of more favourable remodelling after AMI. These findings identify a potential new target for the treatment of postinfarction remodelling.
- Published
- 2004
- Full Text
- View/download PDF
26. Expression of angiogenic factors during acute coronary syndromes in human type 2 diabetes.
- Author
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Marfella R, Esposito K, Nappo F, Siniscalchi M, Sasso FC, Portoghese M, Di Marino MP, Baldi A, Cuzzocrea S, Di Filippo C, Barboso G, Baldi F, Rossi F, D'Amico M, and Giugliano D
- Subjects
- Acute Disease, Angina, Unstable complications, Angina, Unstable surgery, Collateral Circulation physiology, Coronary Artery Bypass, Diabetes Mellitus, Type 2 complications, Female, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Male, Middle Aged, Nitric Oxide Synthase genetics, Nitric Oxide Synthase Type II, RNA, Messenger analysis, Superoxides metabolism, Tyrosine metabolism, Ventricular Function, Angina, Unstable physiopathology, Diabetes Mellitus, Type 2 physiopathology, Transcription Factors genetics, Tyrosine analogs & derivatives, Vascular Endothelial Growth Factor A genetics
- Abstract
Inadequate angiogenic response to ischemia in diabetic myocardium could result in poor collateral formation. Because hypoxia-inducible factor (HIF)-1alpha is a transcriptional activator of vascular endothelial growth factor (VEGF) and is critical for initiating angiogenic responses to hypoxia, we investigated the expression of HIF-1alpha and VEGF in specimens of human heart tissue to elucidate the molecular responses to myocardial ischemia in diabetic patients during unstable angina. Moreover, accumulation of a marker of protein nitration nitrotyrosine, as well as the superoxide anion (O(2)(-)) levels and inducible nitric oxide synthase (iNOS), were evaluated. Ventricular biopsy specimens from 15 type 2 diabetic and 14 nondiabetic patients presenting with unstable angina (ischemic group) and from 20 patients (11 type 2 diabetic and 9 nondiabetic patients) who underwent coronary bypass surgery without angina within the preceding 10 days (control group) were collected during coronary bypass surgery. Nondiabetic patients had higher HIF-1alpha and VEGF expressions compared with diabetic patients (P < 0.001). As compared with nondiabetic specimens, diabetic specimens showed higher levels of both iNOS mRNA and protein levels (P < 0.001) associated with the highest tissue levels of nitrotyrosine and O(2)(-) (P < 0.001). Diabetes is associated with increased myocardial tissue levels of iNOS, O(2)(-), and nitrotyrosine and reduced expression of myocardial angiogenesis factors during ischemia.
- Published
- 2004
- Full Text
- View/download PDF
27. Prognostic significance of cyclooxygenase-2 (COX-2) and expression of cell cycle inhibitors p21 and p27 in human pleural malignant mesothelioma.
- Author
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Baldi A, Santini D, Vasaturo F, Santini M, Vicidomini G, Di Marino MP, Esposito V, Groeger AM, Liuzzi G, Vincenzi B, Tonini G, Piccoli M, Baldi F, and Scarpa S
- Subjects
- Cyclin-Dependent Kinase Inhibitor p21, Cyclin-Dependent Kinase Inhibitor p27, Cyclooxygenase 2, Humans, Immunohistochemistry, Membrane Proteins, Mesothelioma mortality, Pleural Neoplasms mortality, Prognosis, Survival Analysis, Survival Rate, Tumor Suppressor Protein p53 metabolism, Cell Cycle Proteins metabolism, Cyclins metabolism, Isoenzymes metabolism, Mesothelioma metabolism, Pleural Neoplasms metabolism, Prostaglandin-Endoperoxide Synthases metabolism, Tumor Suppressor Proteins metabolism
- Abstract
Background: A study was undertaken to analyse the potential prognostic value of the immunohistochemical expression of cyclooxygenase-2 (COX-2) and p27 in 29 malignant mesotheliomas already screened for the expression of p21 and p53., Methods: Immunohistochemistry was used to determine the expression of COX-2 and p27. The correlation with survival of these factors and of p21 and p53 expression was assessed by univariate and multivariate analyses., Results: A positive statistically significant correlation was found between p27 and p21 expression (p<0.0001), but there was a negative correlation between COX-2 expression and both p27 (p = 0.001) and p21 (p<0.0001). No statistically significant correlation was recorded between p53 and all the other immunohistochemical parameters. Univariate analysis showed that overall survival was strongly influenced by p21, p27, and COX-2 expression, but multivariate Cox regression analysis showed that the only immunohistochemical parameter to influence overall survival of patients with mesothelioma was COX-2., Conclusions: These findings suggest that COX-2 expression may be a useful prognostic parameter for mesothelioma.
- Published
- 2004
- Full Text
- View/download PDF
28. Pleomorphic adenoma of cervical heterotopic salivary glands.
- Author
-
Baldi A, Persichetti P, Di Marino MP, Nicoletti G, and Baldi F
- Subjects
- Adult, Humans, Male, Adenoma, Pleomorphic pathology, Salivary Gland Neoplasms pathology
- Abstract
Neoplastic transformation of heterotopic cervical salivary gland tissue is extremely rare. The Authors describe a case of pleomorphic adenoma arising in this tissue, on the right side of the neck in a 40-year old man. The characteristics of salivary heterotipias of the neck, and their diagnostic difficulties and histogenetic problems are reviewed.
- Published
- 2003
29. Cystitis glanduralis complicating an eosinophilic cystitis: a case report.
- Author
-
Baldi A, Di Marino MP, Persichetti P, Ferrara N, and Baldi F
- Subjects
- Adult, Biopsy, Cystitis pathology, Eosinophilia pathology, Humans, Male, Urothelium pathology, Cystitis complications, Eosinophilia complications, Urinary Bladder pathology
- Abstract
We report on a rare case of cystitis glandularis complicating an eosinophilic cystitis in an adult. Complaints at presentation included dysuria, haematuria and abdominal pain. Ultrasound and cystoscopy suggested a bladder tumor. Histological analysis of bladder biopsy showed the typical findings of cystitis glandularis associated with eosinophilic cystitis. The patient was treated with transurethral resection of the lesion and a combination of corticosteroids and anthistaminics for three months. He is disease-free at 24 months of follow-up.
- Published
- 2003
30. Expression of p21 in SV40 large T antigen positive human pleural mesothelioma: relationship with survival.
- Author
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Baldi A, Groeger AM, Esposito V, Cassandro R, Tonini G, Battista T, Di Marino MP, Vincenzi B, Santini M, Angelini A, Rossiello R, Baldi F, and Paggi MG
- Subjects
- Antigens, Viral immunology, Cyclin-Dependent Kinase Inhibitor p21, Humans, Immunohistochemistry methods, Mesothelioma mortality, Pleural Neoplasms mortality, Survival Analysis, T-Lymphocytes immunology, Cyclins metabolism, Mesothelioma metabolism, Pleural Neoplasms metabolism, Simian virus 40 immunology
- Abstract
Background: Mesothelioma is the most commonly occurring primary pleural neoplasm. Several studies have documented an increase in the incidence of this malignancy during the last decades. Although the association between asbestos exposure and development of mesothelioma is generally accepted, the exact mechanism of carcinogenesis is unknown. Recently, Simian virus 40 large T antigen (SV40 Tag) expression has been detected in pleural mesothelioma. The ability of SV40 oncoproteins to inactivate p53 and retinoblastoma tumour suppressor proteins has been proposed as an important step in the pathogenesis of human mesothelioma., Methods: To obtain a better understanding of the molecular mechanisms of the pathogenesis of mesothelioma, the expression of the cell cycle inhibitor p21(WAF1/CIP1) (p21), a downstream target of p53, was evaluated immunohistochemically in a group of 29 mesothelioma specimens already characterised for the presence of SV40 Tag sequences., Results: Statistical analysis did not reveal any correlation between p21 expression and histopathological type of mesothelioma using the kappa(2) test (p=0.577). A significant positive relationship was found between p21 expression level and the patients' overall survival according to the Kaplan-Meier survival curves and using a log rank test (median difference in survival 7 months, 95% CI 4.8 to 9.9; p<0.001)., Conclusions: Determination of p21 expression bears a prognostic significance in patients affected with mesothelioma, further underlining the role of SV40 in the pathogenesis of malignant pleural mesothelioma.
- Published
- 2002
- Full Text
- View/download PDF
31. Non-alcoholic fatty liver disease in an area of southern Italy: main clinical, histological, and pathophysiological aspects.
- Author
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Loguercio C, De Girolamo V, de Sio I, Tuccillo C, Ascione A, Baldi F, Budillon G, Cimino L, Di Carlo A, Di Marino MP, Morisco F, Picciotto F, Terracciano L, Vecchione R, Verde V, and Del Vecchio Blanco C
- Subjects
- Adolescent, Adult, Aged, Alanine Transaminase blood, Alcohol Drinking epidemiology, Alkaline Phosphatase blood, Aspartate Aminotransferases blood, Blood Glucose metabolism, Body Mass Index, Cholesterol blood, Diabetes Mellitus genetics, Energy Intake, Fatty Liver etiology, Fatty Liver pathology, Female, Humans, Insulin blood, Insulin metabolism, Insulin Secretion, Iron blood, Italy, Liver Diseases genetics, Male, Malondialdehyde analysis, Middle Aged, Sex Characteristics, Triglycerides blood, Fatty Liver physiopathology
- Abstract
Background/aims: Studies on non-alcoholic fatty liver disease (NAFLD) have included chronic liver damage attributed to various causes. Our investigation was held to observe the main clinical, histological, and pathophysiological aspects of NAFLD in patients not exposed to any known cause of chronic liver disease., Methods: We evaluated, in 84 in-patients (male/female, 66/18; median age, 36 years), the clinical and biochemical characteristics of NAFLD, and particularly its association with diabetes, dyslipidemia, hyperinsulinemia and/or with the increase of parameters of oxidative stress (blood levels of malonyldialdehyde, 4-hydroxynonenal and total plasma antioxidant capacity)., Results: Ninety percent of patients had an increased body mass index (BMI), 35% had dyslipidemia, 40% had sub-clinical diabetes (only 3% had overt diabetes), 60% had hyperinsulinemia, and more than 90% had enhanced levels of lipid peroxidation markers. In 48 patients who had consented to liver biopsy, we found: 14 with simple steatosis, 32 with steatohepatitis, and two with cirrhosis., Conclusions: Our data indicate that in our country, NAFLD may occur in young males with an increased BMI, with or without hyperinsulinemia, dyslipidemia and diabetes, generally associated with disorders of redox status, and that it may be differentiated from steatosis to steatohepatitis or cirrhosis only with a liver biopsy.
- Published
- 2001
- Full Text
- View/download PDF
32. Drinking habits of subjects with hepatitis C virus-related chronic liver disease: prevalence and effect on clinical, virological and pathological aspects.
- Author
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Loguercio C, Di Pierro M, Di Marino MP, Federico A, Disalvo D, Crafa E, Tuccillo C, Baldi F, and del VecchioBlanco C
- Subjects
- Adult, Aged, Alcohol Drinking epidemiology, Alcoholism epidemiology, Antiviral Agents therapeutic use, Biomarkers blood, Female, Hepacivirus metabolism, Hepatitis C, Chronic drug therapy, Hepatitis C, Chronic epidemiology, Humans, Interferons therapeutic use, Italy epidemiology, Liver Cirrhosis drug therapy, Male, Middle Aged, Statistics, Nonparametric, Temperance psychology, gamma-Glutamyltransferase blood, Alcohol Drinking psychology, Alcoholism psychology, Hepatitis C, Chronic psychology, Liver Cirrhosis psychology
- Abstract
Alcohol changes the progression of hepatitis C virus (HCV)-related chronic liver disease and may affect the outcome of interferon therapy. The ethanol intake of 245 patients with biopsy-proven chronic hepatitis C with or without cirrhosis, its interaction with laboratory and histological parameters common to alcohol and HCV-mediated liver damage, and its effects on therapy were evaluated. The results show that 60-70% of subjects regularly consumed alcohol (median intake >40 g/day in about 30%). Less than 50% stopped drinking after being diagnosed as having liver disease. Ethanol intake affected: fibrosis, especially in women, HCV RNA levels, which were significantly lower in abstainers than in drinkers (0.6 +/- 0.3 vs 6.9 +/- 5.9 Eq/ml x10(6); P < 0.01), and response to interferon therapy. The number of responders decreased as ethanol intake increased. There were less abstainers than drinkers among non-responders (10.7% vs 63.1% respectively; P < 0.001). Data indicate that alcohol will induce and worsen liver damage and, in subjects with chronic liver disease who continue to drink, adversely affect their response to treatment.
- Published
- 2000
- Full Text
- View/download PDF
33. Atypical fibroxanthoma with osteoclast-like multinucleated giant cells.
- Author
-
Ferrara N, Baldi G, Di Marino MP, Bellucci G, and Baldi A
- Subjects
- Actins analysis, Aged, Aged, 80 and over, Cell Nucleus pathology, Histiocytoma, Benign Fibrous metabolism, Humans, Immunohistochemistry, Male, Muramidase analysis, Muscle, Smooth chemistry, Osteoclasts pathology, S100 Proteins analysis, Skin Neoplasms metabolism, Histiocytes pathology, Histiocytoma, Benign Fibrous pathology, Skin Neoplasms pathology
- Abstract
Atypical fibroxanthoma (AF) is generally considered as a low grade superficial variant of fibrohistiocytic neoplasm. In this report we present an unusual variant of this neoplasm arising from actinic damaged skin of an elderly individual. The case was characterized by numerous multinucleated osteoclast-like giant cells uniformly scattered through a pleomorfic cellular proliferation. The osteoclasts giant cell observed represent multinucleated histiocytes rather than true osteoclasts.
- Published
- 2000
34. [Basaloid squamous carcinoma of the tongue. Clinico-anatomical study of a case].
- Author
-
Colella G, Baldi F, Lanza A, Di Marino MP, and Tartaro GP
- Subjects
- Aged, Female, Humans, Carcinoma, Transitional Cell pathology, Tongue Neoplasms pathology
- Abstract
The basaloid squamous carcinoma was first described in 1986. It is a rare tumor with particular morphologic and biologic features that separate it from the more common squamous cell carcinoma of the head and neck region. A case with histologic diagnosis of basaloid squamous carcinoma of the tongue treated only with radiotherapy, is reported.
- Published
- 1999
35. Relapsing pneumothorax due to Ascaris lumbricoides larvae.
- Author
-
Santini M, Baldi A, Vicidomini G, Di Marino MP, and Baldi F
- Subjects
- Animals, Ascariasis diagnosis, Ascariasis surgery, Child, Humans, Larva, Male, Pneumothorax surgery, Ascariasis complications, Ascaris lumbricoides, Pneumothorax parasitology
- Abstract
We describe a case of relapsing pneumothorax occurring in a male child aged 11 yrs, resulting from the mechanical inflammatory action of Ascaris lumbricoides larvae localized in the pleuropulmonary tissue. Pulmonary ascariasis should still be considered today in the differential diagnosis of spontaneous pneumothorax occurring in children.
- Published
- 1999
36. Lymphomatoid granulomatosis of the lung: a clinico-pathological study.
- Author
-
Baldi A, Groeger AM, Esposito V, Di Lieto E, Di Marino MP, Santini D, and Baldi F
- Subjects
- Antigens, CD analysis, B-Lymphocytes immunology, B-Lymphocytes pathology, Chemotherapy, Adjuvant, Cisplatin therapeutic use, Disease-Free Survival, Humans, Lung Neoplasms drug therapy, Lung Neoplasms immunology, Lung Neoplasms surgery, Lymphocytes, Tumor-Infiltrating immunology, Lymphocytes, Tumor-Infiltrating pathology, Lymphomatoid Granulomatosis drug therapy, Lymphomatoid Granulomatosis immunology, Lymphomatoid Granulomatosis surgery, T-Lymphocytes immunology, T-Lymphocytes pathology, Time Factors, Lung Neoplasms pathology, Lymphomatoid Granulomatosis pathology
- Abstract
Lymphomatoid granulomatosis is the only form of pulmonary angiitis histologically characterized by a necrotizing angiocentric and angiodestructive lymphoid infiltrate, with an admixed T-cell reaction. We evaluated three patients with a single lung nodule not diagnosed by routine radiological and endoscopic assays. Our investigations showed a prevalence of T-cells in areas of diffuse infiltration, which were actively replacing reactive follicular areas of B-cells, similarly to T-cell lymphomas. Further pathologic assays suggested the histologic diagnosis of grade I lymphomatoid granulomatosis for all three evaluated specimens. After two years, patients treated with a combination of surgical resection and chemotherapy were disease free, supporting the efficacy of aggressive therapy in the management of this often mistreated group of lymphoid proliferations.
- Published
- 1998
37. Crohn's disease in infancy: a case report.
- Author
-
Baldi A, Di Marino MP, Vicidomini G, and Baldi F
- Subjects
- Crohn Disease diagnostic imaging, Crohn Disease pathology, Female, Humans, Infant, Infant, Newborn, Intestines diagnostic imaging, Intestines pathology, Radiography, Crohn Disease congenital
- Abstract
Crohn's disease in infants is infrequent. We describe here the case of a baby girl born at the 33rd week of pregnancy, that underwent surgery at the age of 55 days for intestinal occlusion. This was found to be due to stenosis of the right colonic flexure associated with cecum, appendix and terminal ileum. Microscopic examination showed features consistent with Crohn's disease. Eleven years after surgery, followed by cortisone therapy, the patient shows normal growth and is asymptomatic.
- Published
- 1998
38. [Pulmonary blastoma in adults].
- Author
-
Di Lieto E, Baldi A, Vicidomini G, Di Marino MP, and Baldi F
- Subjects
- Age Factors, Female, Follow-Up Studies, Humans, Lung pathology, Lung Neoplasms diagnosis, Lung Neoplasms pathology, Middle Aged, Prognosis, Pulmonary Blastoma diagnosis, Pulmonary Blastoma pathology, Radiography, Thoracic, Time Factors, Lung Neoplasms surgery, Pulmonary Blastoma surgery
- Abstract
Pulmonary blastoma is a rare tumor of the lung consisting of immature mesenchyma and epithelial structures that can mimic the structure of the embryonic lung. In this article, we report a case of pulmonary blastoma occurred in an adult individual. We review the literature concerning this rare neoplasm that includes less than one hundred cases reported. We also describe the pathologic features of this disease which is microscopically divided in two classes: 1) lesions composed solely of malignant gland of embryonic appearance (WDFA: Well-Differentiated Fetal Adenocarcinomas), and 2) lesions with biphasic appearance, containing both neoplastic glands and either adult sarcomatous or embryonic mesenchyme. The adult pulmonary blastomas are considered as an entity distinct from childhood blastomas. This condition may be frequently asymptomatic; if symptomatic, it show the same clinical picture of a mass in the lung impinging on bronchi or pleura; the most usual symptoms include cough, hemoptysis, and chest pain. Chest radiography typically shows a peripheral or central lung opacity without preference for any lobe. The prognosis is poor, due to the high incidence of metastasis. Histologic class and clinical findings can be of prognostic value in pulmonary blastoma. We believe that an early diagnosis is essential: in our case, this allowed a complete resection of the tumor and the patient is still alive without recurrence 3 years after the surgical treatment.
- Published
- 1997
39. [Cystic adenomatoid malformation of the lung in an adult].
- Author
-
Vicidomini G, Santini M, Baldi A, Cesarano T, Di Marino MP, and Baldi F
- Subjects
- Cystic Adenomatoid Malformation of Lung, Congenital pathology, Cystic Adenomatoid Malformation of Lung, Congenital surgery, Humans, Lung pathology, Male, Middle Aged, Pneumonectomy, Cystic Adenomatoid Malformation of Lung, Congenital diagnosis
- Abstract
Congenital cystic adenomatoid malformation of the lung (CCAM) is characterized by an adenomatoid proliferation of bronchiole-like structures and cysts formation. The condition is most commonly found in newborns and children and it may be associated with other malformations; rarely, the presentation is delayed until adulthood. This paper presents a case of CCAM in a 62-year-old male, who presented with recurrent bacterial pneumonias and breathlessness one exertion. The chest X-rays and CT scan revealed a patchy opacity in the right lower pulmonary zone. Bronchoscopic examination was normal. At surgery, a mass involving the right lower and middle lobes, and enlargement of hilar lymph nodes were found. A bilobectomy was performed without complications. Examination of the gross specimen showed a lesion characterised by multiple small cysts, all less than 1 cm in diameter; they were lined predominately by columnar epithelium, occasionally by ciliated epithelium. Rare cysts were lined by foreign body giant cells. Elastic fibers and smooth muscle were present within the cysts wall. Peripherally, there were normal alveoli and bronchioli mixed with cysts, and plasmalymphocytic infiltrates. The final diagnosis was Stocker's Type II CCAM of the lung. CCAM of the lung is a rare development lesion of the lung and it has no sexual predilection. It is usually unilateral and sublobar or lobar in size, but occasionally it can be multilobar. Typical histologic feature of CCAM are adenomatoid proliferation of bronchiole-like structures and macro- or microcysts lined by columnar or cuboidal epithelium and absence of cartilage and bronchial glands. Inflammatory changes are not found in infants, but may be present in adult patients. Based on the size of the cysts, CCAM may be classified into three different types: type I characterised by multiple cysts, over than 1 cm in diameter; type II with smaller cysts, less than 1 cm in diameter; type III that shows solid lesions composed of bronchiole-like structures. Type II is commonly found in childhood, but is occasionally seen in adult patients, as that one in our report. The insult probably occurs between 4th and 7th week of fetal life. The etiologic agent is unknown. The histologic diagnosis of CCAM is difficult in adult patient, perhaps because of supervening infections that sometimes distort the underlying diagnostic pathologic appearances and make them difficult to recognise, as happened in our case. From the clinical point of view, most of the lesions cause severe respiratory failure; in adult individuals the diagnosis is difficult, since there are very few relevant symptoms and signs. The patients can present with fever, recurrent infections, breathlessness and haemoptysis. The chest X-rays abnormalities are not specific and include homogeneous or multicystic opacities. Similarly, other diagnostic methods add no further useful informations. Surgical treatment is necessary also in adult patients, because of the risk of recurrent pulmonary infections and malignancies associated with CCAM. Lobectomy is the treatment of choice, but sometimes a larger resection is required, when the lesion involves more than one lobe.
- Published
- 1997
40. Subchorionic placental cyst: histopathological and clinical aspects in two cases.
- Author
-
Ferrara N, Menditto C, Di Marino MP, Ciccarelli A, Gerosolima G, and Menditto V
- Subjects
- Adult, Female, Humans, Placenta Diseases pathology, Pregnancy, Chorion pathology, Cysts pathology, Pregnancy Complications pathology
- Abstract
Authors report here two cases of subchorionic placental cysts with diameters of 5 x 6 cm and 10 x 12 cm, respectively, diagnosed by ultrasound in pregnancy. Subsequent histological and biochemical examinations seem to prove their origin from the trophoblastic "X-cells" and confirm their frequent benign nature.
- Published
- 1996
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