1. Optical coherence tomography angiography findings in Huntington’s disease
- Author
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Giuseppe De Michele, Daniela Montorio, Gilda Cennamo, Laura Giovanna Di Maio, Elena Salvatore, Pasquale Dolce, Silvio Peluso, Di Maio, L. G., Montorio, D., Peluso, S., Dolce, P., Salvatore, E., De Michele, G., and Cennamo, G.
- Subjects
medicine.medical_specialty ,Neurology ,genetic structures ,Central choroidal thickne ,Dermatology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Huntington's disease ,Ophthalmology ,medicine ,030212 general & internal medicine ,Prospective cohort study ,Neuroradiology ,business.industry ,Retinal ,General Medicine ,Huntington disease ,medicine.disease ,Neurovascular bundle ,eye diseases ,Pathophysiology ,Optical coherence tomography angiography ,Psychiatry and Mental health ,chemistry ,sense organs ,Neurology (clinical) ,Neurosurgery ,business ,030217 neurology & neurosurgery ,Vessel density - Abstract
Objectives: To evaluate the retinal and choriocapillaris vascular networks in macular region and the central choroidal thickness (CCT) in patients affected by Huntington disease (HD), using optical coherence tomography angiography (OCTA) and enhanced depth imaging spectral-domain OCT (EDI SD-OCT). Methods: We assessed the vessel density (VD) in superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) using OCTA, while CCT was measured by EDI SD-OCT. Results: Sixteen HD patients (32 eyes) and thirteen healthy controls (26 eyes) were enrolled in this prospective study. No significant difference in retinal and choriocapillaris VD was found between HD patients and controls while CCT turned to be thinner in patients respect to controls. There were no significant relationships between OCTA findings and neurological parameters. Conclusion: The changes in choroidal structure provide useful information regarding the possible neurovascular involvement in the physiopathology of HD. Choroidal vascular network could be a useful parameter to evaluate the vascular impairment that occurs in this neurodegenerative disease.
- Published
- 2021