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28 results on '"Di Lorenzo, Piera"'

6. Mitochondrial DNA variants of Podolian cattle breeds testify for a dual maternal origin

Author

Di Lorenzo, Piera, primary, Lancioni, Hovirag, additional, Ceccobelli, Simone, additional, Colli, Licia, additional, Cardinali, Irene, additional, Karsli, Taki, additional, Capodiferro, Marco Rosario, additional, Sahin, Emine, additional, Ferretti, Luca, additional, Ajmone Marsan, Paolo, additional, Sarti, Francesca Maria, additional, Lasagna, Emiliano, additional, Panella, Francesco, additional, and Achilli, Alessandro, additional

Published
2018
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9. PRNP POLYMORPHISMS IN FOUR ITALIAN SHEEP BREEDS

Author

Lasagna, Emiliano, Curcio, Ludovica, Sebastiani, Carla, Ciullo, Marcella, DI LORENZO, Piera, Ceccobelli, Simone, Sarti, Francesca Maria, Pezzotti, Giovanni, and Biagetti, Massimo

Published
2015

15. Influence of single nucleotide polymorphisms in the myostatin and myogenic factor 5 muscle growth-related genes on the performance traits of Marchigiana beef cattle

Author

Sarti, Francesca Maria, Lasagna, Emiliano, Ceccobelli, Simone, DI LORENZO, Piera, Filippini, F., Sbarra, F., Giontella, Andrea, Pieramati, Camillo, and Panella, Francesco

Subjects
molecular markers, Genotype, animal breeding, candidate genes, Italian beef cattle, Animals, Cattle, Myogenic Regulatory Factor 5, Myostatin, Polymorphism, Single Nucleotide
Abstract

The Marchigiana is famous for its large body size and favorable dressing percentage. A myostatin (MSTN) gene mutation (a G to T transversion) was identified in the breed. The homozygote "GG" yields a "normal" phenotype, the homozygote "TT" yields a double muscled body shape but sometimes causes survival problems, and the heterozygote genotype produces an extremely muscled body without defects. In practice, Marchigiana "TT" homozygotes are culled from reproduction, but the heterozygotes are chosen as sires. The objective of this study was to assess genes involved in Marchigiana muscle development to improve selection procedures. The effects of the MSTN and myogenic factor 5 (MYF5) genes on the growth and muscle traits in the Marchigiana breed were assessed. The effects of MSTN together with the genotype of the causative mutation (g.874GT) and the effects of the two SNP in the promoter were studied (g.-371TA and g.-805GC). The SNP effects were evaluated in a comparison between the means of the several genotypes or for the average gene substitution and dominance effect. Two hundred forty-nine bullocks were evaluated using a performance test. At the beginning and end of the trial, the animals were weighed and their bodies were measured every 21 d up to 12 mo of age. In addition to these observations, morphological scores and the BLUP indices were estimated at the end of the performance test. The obtained results suggested that the MSTN g.874GT and MYF5 SNP could be considered in the selection program of the Marchigiana breed. A MSTN g.874GT genotyping service for the breeders could help to avoid the "TT" genotype and to select for the "GT" genotype. The "AA" MYF5 SNP genotype could also be selected for even if good muscle development yields a certain size reduction.

Published
2014

28. Genetic Differentiation Between Segugio Dell’Appeinninoand Segugio MaremmanoDog Breeds Assessed by Microsatellite Markers

Author

La Manna, Vincenzo, Lasagna, Emiliano, Ceccobelli, Simone, Di Lorenzo, Piera, De Cosmo, Attilio M., Attard, George, Sarti, Francesca M., Panella, Francesco, and Renieri, Carlo

Abstract

The domestic dog (Canis Familiaris) was the first species to be tamed and bred to occupy a variety of functions. The Segugio dell’Appenninoand Segugio Maremmanoare two Italian breeds used extensively as hunting dogs. Microsatellites and other genetic markers are useful tools in evaluating the within and between breed genetic variation. The aim of this study was to investigate genetic differentiation among the two breeds through the analysis of 21 microsatellite markers. The two populations share the same geographical regions but have been over time selected on different parameters to achieve specific functions. All the analysed microsatellite markers were polymorphic and the average number of alleles per locus was 8.19. The mean FITindex (0.051; P<0.05) highlights that at some point in time, the normal gene flow among the animals was disrupted, giving rise to a heterozygote deficiency in both breeds, and this is confirmed by the mean FSTfixation index (0.010; P<0.05) clearly indicating an absence of a significant genetic differentiation between the two breeds. The mean FISvalue was significantly different from zero (0.042) (P<0.05) reconfirming the presence of a lack of heterozygosity in the studied samples. The values of observed and expected heterozygosity were similar in the two breeds. AMOVA, PCA and STRUCTURE analysis, all emphasise the lack of significant differences among the two breeds in terms of genetic differentiation. The presence of a population substructure is probably due to a genetic introgression from different Segugio breeds, that can be confirmed with further studies.

Published
2015
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