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2. Assessment of alternative covariance functions for joint input-state estimation via Gaussian Process latent force models in structural dynamics

Author

Vettori, Silvia, Di Lorenzo, Emilio, Peeters, Bart, and Chatzi, Eleni

Subjects
Statistics - Applications
Abstract

Digital technologies can be used to gather accurate information about the behavior of structural components for improving systems design, as well as for enabling advanced Structural Health Monitoring strategies. New avenues for achieving automated and continuous structural assessment are opened up via development of virtualization approaches delivering so-called Digital Twins, i.e., digital mirrored representations of physical. In this framework, the main motivation of this work stems from the existing challenges in the implementation and deployment of a real-time predictive framework for virtualization of dynamic systems. Kalman-based filters are usually employed in this context to address the task of joint input-state prediction in structural dynamics. A Gaussian Process Latent Force Model (GPLFM) approach is exploited in this work to construct flexible data-driven a priori models for the unknown inputs, which are then coupled with a mechanistic model of the structural component under study for input-state estimation. The use of GP regression for this task overcomes the limitations of the conventional random-walk model, thus limiting the necessity of offline user-dependent calibration of this type of data assimilation methods. This paper proposes the use of alternative covariance functions for GP regression in structural dynamics. A theoretical analysis of the GPLFMs linked to the investigated covariance functions is offered. The outcome of this study provides insights into the applicability of each covariance type for GP-based input-state estimation. The proposed framework is validated via an illustrative simulated example, namely a 3 Degrees of Freedom system subjected to an array of different loading scenarios. Additionally, the performance of the method is experimentally assessed on the task of joint input-state estimation during testing of a 3D-printed scaled wind turbine blade.

Published
2023

5. Operational Modal Testing of Large Wind Turbine Blades

Author

Peeters, Bart, Orlowitz, Esben, Di Lorenzo, Emilio, Mastrodicasa, Davide, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Rainieri, Carlo, editor, Gentile, Carmelo, editor, and Aenlle López, Manuel, editor

Published
2024
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6. Experimental Dynamic Investigation of a Small-Scale Wind Turbine

Author

Vettori, Silvia, Antonaci, Alessia, Mastroianni, Lorenzo Vincenzo, Di Lorenzo, Emilio, Pagani, Alfonso, Cosco, Francesco, Peeters, Bart, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Rainieri, Carlo, editor, Gentile, Carmelo, editor, and Aenlle López, Manuel, editor

Published
2024
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7. Monitoring Damage Progression in Wind Turbine Blade Under Fatigue Testing Using Acceleration Measurements

Author

Rossi, Pamela, Tavares, André, Di Lorenzo, Emilio, Cornelis, Bram, Luczak, Marcin, Branner, Kim, Gryllias, Konstantinos, Coppotelli, Giuliano, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Rainieri, Carlo, editor, Gentile, Carmelo, editor, and Aenlle López, Manuel, editor

Published
2024
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13. Machine Learning Techniques for Damage Detection in Wind Turbine Blades

Author

Tavares, André, Lopes, Bernardo, Di Lorenzo, Emilio, Cornelis, Bram, Peeters, Bart, Desmet, Wim, Gryllias, Konstantinos, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Rizzo, Piervincenzo, editor, and Milazzo, Alberto, editor

Published
2023
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15. Rationale and design of the PARTHENOPE trial: A two-by-two factorial comparison of polymer-free vs biodegradable-polymer drug-eluting stents and personalized vs standard duration of dual antiplatelet therapy in all-comers undergoing PCI

Author

Piccolo, Raffaele, Calabrò, Paolo, Varricchio, Attilio, Baldi, Cesare, Napolitano, Giovanni, De Simone, Ciro, Mauro, Ciro, Stabile, Eugenio, Caiazzo, Gianluca, Tesorio, Tullio, Boccalatte, Marco, Tuccillo, Bernardino, Bottiglieri, Giuseppe, Russolillo, Enrico, Di Lorenzo, Emilio, Carrara, Greta, Cassese, Salvatore, Leonardi, Sergio, Biscaglia, Simone, Costa, Francesco, McFadden, Eugene, Heg, Dik, Franzone, Anna, Stefanini, Giulio G., Capodanno, Davide, and Esposito, Giovanni

Published
2023
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18. Pharmacologic Treatment of Pulmonary Hypertension Due to Heart Failure with Preserved Ejection Fraction: Are There More Arrows on Our Bow?

Author

Masarone, Daniele, Valente, Fabio, Verrengia, Marina, Contaldi, Carla, di Palma, Vito, Falco, Luigi, Catapano, Dario, and di Lorenzo, Emilio

Abstract

Pulmonary hypertension (PH) associated with heart failure with preserved ejection fraction (PH-HFpEF) represents a frequent form of PH related to left ventricular dysfunction. The pathophysiology of PH-HFpEF is intricate, and varied and includes vascular, cardiac, and pulmonary factors that contribute synergistically to developing this clinical syndrome. Improved knowledge of the pathophysiology of PH-HFpEF has paved the way for the use of new drugs such as angiotensin receptor neprilysin inhibitors (ARNIs), non-steroidal mineral corticoid receptor antagonist (nsMRA), sodium-glucose cotransporter inhibitors (SGLT2is), levosimendan, and glucagon-like peptide 1 (GLP-1) agonists. ARNIs are a widely used drug for the treatment of PH associated with heart failure with reduced ejection fraction. They have also recently been used in PH-HFpEF patients with hemodynamic benefits that need to be confirmed in future research. Finerenone is an innovative non-steroidal mineralocorticoid receptor antagonist that exhibits notable cardioprotective and renoprotective properties in individuals suffering from chronic diabetic kidney disease. It also enhances outcomes for patients with heart failure, whether they have mildly reduced or preserved ejection fraction. Moreover, in experimental studies, finerenone has been found to lower pulmonary artery pressure, reduce muscularization, and decrease the wall thickness of pulmonary arteries. SGLT2i have revolutionized the treatment of patients with heart failure irrespective of left ventricular ejection fraction, and their treatment is also associated with an improvement in the hemodynamics profile in patients with PH-HFpEF. Levosimendan is a widely used inodilator in the treatment of acute and advanced heart failure. In addition, its use in patients with PH-HFpEF (supported by the positive effects on pulmonary hemodynamics that levosimendan exerts) has recently demonstrated hemodynamic benefit in a small phase 2 study that paved the way for phase 3 studies and the creation of an oral formulation of levosimendan. Finally, GLP1 agonists are a class of drugs that, in preliminary evidence, have shown a positive effect on cardiac hemodynamics, mainly by facilitating left ventricular unloading. These effects, along with the reduction in insulin resistance and weight loss, likely lead to beneficial outcomes for PH-HFpEF patients, especially those with obesity as a comorbidity. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Efficacy and Safety of Stents in ST-Segment Elevation Myocardial Infarction

Author

Chichareon, Ply, Modolo, Rodrigo, Collet, Carlos, Tenekecioglu, Erhan, Vink, Maarten A., Oh, Pyung Chun, Ahn, Jung-Min, Musto, Carmine, Díaz de la Llera, Luis S., Cho, Young-Seok, Violini, Roberto, Park, Seung-Jung, Suryapranata, Harry, Piek, Jan J., de Winter, Robbert J., Wykrzykowska, Joanna J., Spaulding, Christian, Kang, Woong Chol, Slagboom, Ton, Hofma, Sjoerd H., Wijnbergen, Inge F., Di Lorenzo, Emilio, Pijls, Nico H., Räber, Lorenz, Brugaletta, Salvatore, Sabaté, Manel, Stoll, Hans-Peter, Stone, Gregg W., Windecker, Stephan, Onuma, Yoshinobu, and Serruys, Patrick W.

Published
2019
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32. Population Trends in Rates of Percutaneous Coronary Revascularization for Acute Coronary Syndromes Associated With the COVID-19 Outbreak

Author

Piccolo, Raffaele, Bruzzese, Dario, Mauro, Ciro, Aloia, Antonio, Baldi, Cesare, Boccalatte, Marco, Bottiglieri, Giuseppe, Briguori, Carlo, Caiazzo, Gianluca, Calabrò, Paolo, Cappelli-Bigazzi, Maurizio, De Simone, Ciro, Di Lorenzo, Emilio, Golino, Paolo, Monda, Vittorio, Perrotta, Rocco, Quaranta, Gaetano, Russolillo, Enrico, Scherillo, Marino, Tesorio, Tullio, Tuccillo, Bernardino, Valva, Giuseppe, Villari, Bruno, Tarantini, Giuseppe, Varricchio, Attilio, and Esposito, Giovanni

Published
2020
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35. Type of hospitalisations and in-hospital outcomes in the Italian coronary care unit network at the time of COVID-19 pandemic: the BLITZ-COVID19 Registry

Author

Gulizia, Michele Massimo, primary, Fabbri, Gianna, additional, Lucci, Donata, additional, Di Pasquale, Giuseppe, additional, Gabrielli, Domenico, additional, Campodonico, Jeness, additional, Mauro, Andrea, additional, Inciardi, Riccardo, additional, Di Lorenzo, Emilio, additional, Oliva, Fabrizio, additional, Nardi, Federico, additional, Colivicchi, Furio, additional, and De Luca, Leonardo, additional

Published
2022
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37. Impact of hypertension on clinical outcome in STEMI patients undergoing primary angioplasty with BMS or DES: Insights from the DESERT cooperation

Author

De Luca, Giuseppe, Dirksen, Maurits T., Spaulding, Christian, Kelbæk, Henning, Schalij, Martin, Thuesen, Leif, van der Hoeven, Bas, Vink, Marteen A., Kaiser, Christoph, Musto, Carmine, Chechi, Tania, Spaziani, Gaia, Diaz de la Llera, Luis Salvador, Pasceri, Vincenzo, Di Lorenzo, Emilio, Violini, Roberto, Suryapranata, Harry, and Stone, Gregg W.

Published
2014
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39. Impact of Age on Long-Term Outcome After Primary Angioplasty With Bare-Metal or Drug-Eluting Stent (from the DESERT Cooperation)

Author

De Luca, Giuseppe, Dirksen, Maurits T., Spaulding, Christian, Kelbæk, Henning, Schalij, Martin, Thuesen, Leif, van der Hoeven, Bas, Vink, Marteen A., Kaiser, Christoph, Musto, Carmine, Chechi, Tania, Spaziani, Gaia, Diaz de la Llera, Luis Salvador, Pasceri, Vincenzo, Di Lorenzo, Emilio, Violini, Roberto, Suryapranata, Harry, and Stone, Gregg W.

Published
2013
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40. Meta-Analysis Comparing Efficacy and Safety of First Generation Drug-Eluting Stents to Bare-Metal Stents in Patients With Diabetes Mellitus Undergoing Primary Percutaneous Coronary Intervention

Author

De Luca, Giuseppe, Dirksen, Maurits T., Spaulding, Christian, Kelbæk, Henning, Schalij, Martin, Thuesen, Leif, van der Hoeven, Bas, Vink, Marteen A., Kaiser, Christopher, Musto, Carmine, Chechi, Tania, Spaziani, Gaia, Diaz de la Llera, Luis Salvador, Pasceri, Vincenzo, Di Lorenzo, Emilio, Violini, Roberto, Suryapranata, Harry, and Stone, Gregg W.

Published
2013
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42. Management of Transcatheter Aortic Valve Implantation and Complex Aorta Anatomy: The Importance of Pre-Procedural Planning

Author

Intorcia, Alfredo, primary, Ambrosini, Vittorio, additional, Capasso, Michele, additional, Granata, Riccardo, additional, Magliulo, Fabio, additional, Carbone, Giannignazio Luigi, additional, Capobianco, Stefano, additional, Rotondi, Francesco, additional, Lanni, Francesca, additional, Manganelli, Fiore, additional, and Di Lorenzo, Emilio, additional

Published
2022
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45. Drug-eluting stents in patients with anterior STEMI undergoing primary angioplasty: a substudy of the DESERT cooperation

Author

De Luca, Giuseppe, Dirksen, Maurits T., Spaulding, Christian, Kelbæk, Henning, Schalij, Martin, Thuesen, Leif, van der Hoeven, Bas, Vink, Marteen A., Kaiser, Christoph, Musto, Carmine, Chechi, Tania, Spaziani, Gaia, de la Llera, Luis Salvador Diaz, Pasceri, Vincenzo, Di Lorenzo, Emilio, Violini, Roberto, Suryapranata, Harry, and Stone, Gregg W.

Published
2014
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46. Safety and feasibility of balloon aortic valvuloplasty in non-TAVI centers: The 'BAV for life' experience

Author

Attisano, Tiziana, Silverio, Angelo, Stabile, Eugenio, Briguori, Carlo, Tuccillo, Bernardino, Scotto Di Uccio, Fortunato, Di Lorenzo, Emilio, Tesorio, Tullio, Giordano, Arturo, Calabrò, Paolo, Cappelli Bigazzi, Maurizio, Golino, Paolo, Scherillo, Marino, Vigorito, Francesco, Quaranta, Gaetano, Esposito, Giovanni, Mauro, Ciro, Musumeci, Giuseppe, Tarantini, Giuseppe, Galasso, Gennaro, Venuti, Angela, Maione, Antongiulio, Accadia, Maria, Spadaro, Pasquale, Arnese, Maria Rosaria, Pastore, Fabio, Eusebio, Giuseppina, De Angelis, Maria Carmen, Varricchio, Attilio, Alfieri, Alfonso, Di Girolamo, Domenico, Bianchi, Renato Maria, Visconti, Gabriella, Ambrosini, Vittorio, Capasso, Michele, Formigli, Dario, Villari, Bruno, De Simone, Ciro, Manganiello, Vincenzo, Attisano, Tiziana, Silverio, Angelo, Stabile, Eugenio, Briguori, Carlo, Tuccillo, Bernardino, Scotto Di Uccio, Fortunato, Di Lorenzo, Emilio, Tesorio, Tullio, Giordano, Arturo, Calabrò, Paolo, Cappelli Bigazzi, Maurizio, Golino, Paolo, Scherillo, Marino, Vigorito, Francesco, Quaranta, Gaetano, Esposito, Giovanni, Mauro, Ciro, Musumeci, Giuseppe, Tarantini, Giuseppe, Galasso, Gennaro, Venuti, Angela, Maione, Antongiulio, Accadia, Maria, Spadaro, Pasquale, Arnese, Maria Rosaria, Pastore, Fabio, Eusebio, Giuseppina, De Angelis, Maria Carmen, Varricchio, Attilio, Alfieri, Alfonso, Di Girolamo, Domenico, Bianchi, Renato Maria, Visconti, Gabriella, Ambrosini, Vittorio, Capasso, Michele, Formigli, Dario, Villari, Bruno, De Simone, Ciro, and Manganiello, Vincenzo

Subjects
Balloon Valvuloplasty, Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, 030204 cardiovascular system & hematology, Balloon, Group B, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Nuclear Medicine and Imaging, Internal medicine, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Hospital Mortality, Prospective Studies, aortic stenosis, balloon aortic valvuloplasty, transcatheter aortic valve implantation, Radiology, Nuclear Medicine and Imaging, Cardiology and Cardiovascular Medicine, 030212 general & internal medicine, Aged, Training period, Aged, 80 and over, Ejection fraction, business.industry, Cardiogenic shock, Aortic Valve Stenosis, Recovery of Function, General Medicine, aortic stenosi, medicine.disease, Aortic valvuloplasty, Treatment Outcome, Italy, Aortic valve stenosis, Heart failure, Cardiology, Feasibility Studies, Female, Radiology, business
Abstract

Objectives To evaluate the safety and the feasibility of balloon aortic valvuloplasty (BAV) procedure made by trained operators in centers not performing transcatheter aortic valve implantation (TAVI). Background BAV is a valuable therapeutic tool for patients with symptomatic severe aortic valve stenosis (AS) at prohibitive risk for TAVI or surgery. Methods Consecutive high-risk AS patients underwent BAV in five non-TAVI centers, where BAV operators had completed a 6-month training period in high-volume TAVI centers (Group A). All clinical, echocardiographic, and procedural data were prospectively collected and compared with data of patients treated in TAVI center (Group B). Results Between June 2016 and June 2017, 55 patients (83.9 ± 7.0 years) were enrolled: 25 in Group A and 30 in Group B. After BAV, a substantial reduction of the peak-to-peak aortic valve gradient was obtained in both groups (-35.3 ± 15.2 vs -28.8 ± 13.9 mmHg, P =0.25). No major bleeding or vascular complications occurred. In-hospital death was observed in three patients of Group A and two patients of Group B (P =0.493). The mean follow-up time was 303 ± 188 days; no patients were lost. The 1-year survival free from overall death (Group A 75.8% vs Group B 68.8%; P =0.682) and heart failure rehospitalization (Group A 73.0% vs Group B 66.8%; P =0.687) was similar in the two groups. At multivariable analysis, low left ventricular (LV) ejection fraction (HR: 0.943; P = 0.011) and cardiogenic shock (HR: 5.128; P = 0.002) at admission were independent predictors of mortality. Conclusions BAV is a safe and effective procedure that can be performed by trained operators in centers not performing TAVI.

Published
2018
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49. Stents liberadores de fármacos frente a stents convencionales en pacientes diabéticos con infarto agudo de miocardio con elevación del segmento ST: un análisis combinado de los datos de pacientes individuales de 7 ensayos aleatorizados

Author

Iijima, Raisuke, Byrne, Robert A., Dibra, Alban, Ndrepepa, Gjin, Spaulding, Christian, Laarman, Gerrit J., Menichelli, Maurizio, Valgimigli, Marco, Di Lorenzo, Emilio, Kaiser, Christoph, Tierala, Ilkka, Mehilli, Julinda, Suttorp, Maarten J., Violini, Roberto, Schömig, Albert, and Kastrati, Adnan

Published
2009
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50. Drug-Eluting Stents Versus Bare-Metal Stents in Diabetic Patients With ST-Segment Elevation Acute Myocardial Infarction: A Pooled Analysis of Individual Patient Data From 7 Randomized Trials

Author

Iijima, Raisuke, Byrne, Robert A., Dibra, Alban, Ndrepepa, Gjin, Spaulding, Christian, Laarman, Gerrit J., Menichelli, Maurizio, Valgimigli, Marco, Di Lorenzo, Emilio, Kaiser, Christoph, Tierala, Ilkka, Mehilli, Julinda, Suttorp, Maarten J., Violini, Roberto, Schömig, Albert, and Kastrati, Adnan

Published
2009
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