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23 results on '"Di Lillo S"'

1. Introduction

Author

Mainvill Johanne, Di Lillo Sonia, and Poirier Nathalie

2. Couverture

Author

Mainvill Johanne, Di Lillo Sonia, and Poirier Nathalie

4. Remerciements

Author

Mainvill Johanne, Di Lillo Sonia, and Poirier Nathalie

10. Partie 1

Author

Mainvill Johanne, Di Lillo Sonia, and Poirier Nathalie

12. Présentation

Author

Mainvill Johanne, Di Lillo Sonia, and Poirier Nathalie

14. Partie 2

Author

Mainvill Johanne, Di Lillo Sonia, and Poirier Nathalie

15. Partie 3

Author

Mainvill Johanne, Di Lillo Sonia, and Poirier Nathalie

16. Partie 4

Author

Mainvill Johanne, Di Lillo Sonia, and Poirier Nathalie

17. Bibliographie

Author

Mainvill Johanne, Di Lillo Sonia, and Poirier Nathalie

21. Inflammation may modulate IL-6 and C-reactive protein gene expression in the adipose tissue: the role of IL-6 cell membrane receptor

Author

Marco Del Prete, Alfredo Procino, Giovanni Pertosa, Annamaria Colao, Bruno Memoli, Giuseppe Paolo Ferulano, Pasquale Esposito, Michele Andreucci, Brunella Guida, Paolo Calabrò, Silvia Savastano, Clemente Cillo, Giuseppe Grandaliano, Saverio Di Lillo, Memoli, Bruno, Procino, A, Calabrò, P, Esposito, P, Grandaliano, G, Pertosa, G, Del Prete, M, Andreucci, Michele, Di Lillo, S, Ferulano, GIUSEPPE PAOLO, Cillo, Clemente, Savastano, Silvia, Colao, Annamaria, and Guida, Bruna

Subjects
Adult, Male, medicine.medical_specialty, Pathology, Stromal cell, Physiology, Endocrinology, Diabetes and Metabolism, Adipose tissue macrophages, Adipose tissue, Inflammation, Physiology (medical), Internal medicine, Gene expression, medicine, Body Fat Distribution, Humans, Interleukin 6, PRDM16, Regulation of gene expression, biology, Interleukin-6, Middle Aged, Receptors, Interleukin-6, Endocrinology, C-Reactive Protein, Adipose Tissue, Gene Expression Regulation, Organ Specificity, biology.protein, Female, medicine.symptom, Stromal Cells
Abstract

Only few studies have been addressed to the presence and regulation of C-reactive protein (CRP) gene expression in different districts of adipose tissue, and no study has investigated the role of adipose tissue in presence of inflammation. Therefore, the aim of this study was to investigate the inflammatory involvement of either adipose tissue or adipose cells (adipocytes and stromal cells, respectively) in patients with chronic inflammatory disease, focusing on regional adipose tissue CRP gene expression. Eighteen patients with inflammatory disease and 14 healthy controls were enrolled. All subjects underwent specific surgical procedures. Inflamed and noninflamed patients provided samples of subcutaneous and/or omental adipose tissue. All samples were analyzed by RT-PCR and real-time PCR for specific gene expression. In addition, both adipocytes and stromal cells were studied by real-time PCR and immunoprecipitation to evaluate either gene or protein expression of CRP. Our results (real-time PCR) demonstrated a higher gene expression of CRP, IL-6, and both IL-6 membrane receptors in subcutaneous samples of inflamed patients than in healthy controls. Furthermore, in omental fragments of inflamed patients, an enhanced mRNA abundance of the same genes, compared with subcutaneous, was observed. The results obtained at cellular level did not provide evidence of any difference between adipocytes and stromal cell CRP gene expression, whereas immunoprecipitation demonstrated the presence of CRP in inflamed subjects. These results provide first-time evidence of the involvement of adipose tissue in the course of chronic inflammatory diseases, with a different degree of participation of the different adipose tissue districts.

Published
2007

22. Blood pressure control and treatment adherence in hypertensive patients with metabolic syndrome: protocol of a randomized controlled study based on home blood pressure telemonitoring vs. conventional management and assessment of psychological determinants of adherence (TELEBPMET Study).

Author

Parati G, Omboni S, Compare A, Grossi E, Callus E, Venco A, Destro M, Villa G, Palatini P, Rosei EA, Scalvini S, Taddei S, Manfellotto D, Favale S, De Matteis C, Guglielmi M, Lonati L, Della Rosa F, Tosazzi E, Grandi AM, Maresca AM, Mongiardi C, Mare M, Ricci AR, Cagnoni F, Georgatos J, Besostri V, Ferrari V, Omodeo O, Dorigatti F, Bonso E, Guarnieri C, Muiesan L, Paini A, Stassaldi D, Cinelli A, Bernocchi P, Rocchi S, Magagna A, Ghiadoni L, Del Frate I, Boresi F, Guidi A, Re MA, Pellicciotti L, Florio A, Morani G, Di Lillo S, Ambrosio A, Casciello A, Quaglia M, Forleo C, Ardito MA, Gerunda S, and Panunzio M

Subjects
Blood Pressure Monitoring, Ambulatory, Humans, Hypertension physiopathology, Hypertension psychology, Outcome Assessment, Health Care, Clinical Protocols, Hypertension drug therapy, Medication Adherence, Metabolic Syndrome physiopathology, Telemedicine
Abstract

Background: Inadequate blood pressure control and poor adherence to treatment remain among the major limitations in the management of hypertensive patients, particularly of those at high risk of cardiovascular events. Preliminary evidence suggests that home blood pressure telemonitoring (HBPT) might help increasing the chance of achieving blood pressure targets and improve patient's therapeutic adherence. However, all these potential advantages of HBPT have not yet been fully investigated., Methods/design: The purpose of this open label, parallel group, randomized, controlled study is to assess whether, in patients with high cardiovascular risk (treated or untreated essential arterial hypertension--both in the office and in ambulatory conditions over 24 h--and metabolic syndrome), long-term (48 weeks) blood pressure control is more effective when based on HBPT and on the feedback to patients by their doctor between visits, or when based exclusively on blood pressure determination during quarterly office visits (conventional management (CM)). A total of 252 patients will be enrolled and randomized to usual care (n = 84) or HBPT (n = 168). The primary study endpoint will be the rate of subjects achieving normal daytime ambulatory blood pressure targets (< 135/85 mmHg) 24 weeks and 48 weeks after randomization. In addition, the study will assess the psychological determinants of adherence and persistence to drug therapy, through specific psychological tests administered during the course of the study. Other secondary study endpoints will be related to the impact of HBPT on additional clinical and economic outcomes (number of additional medical visits, direct costs of patient management, number of antihypertensive drugs prescribed, level of cardiovascular risk, degree of target organ damage and rate of cardiovascular events, regression of the metabolic syndrome)., Discussion: The TELEBPMET Study will show whether HBPT is effective in improving blood pressure control and related medical and economic outcomes in hypertensive patients with metabolic syndrome. It will also provide a comprehensive understanding of the psychological determinants of medication adherence and blood pressure control of these patients., Trial Registration: Clinical Trials.gov: NCT01541566.

Published
2013
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23. [Evaluation of the effects on the peripheral blood circulation of i.v. administration of high doses of phosphocreatinine in patients with arterial diseases].

Author

de Divitiis O, Abate S, Di Somma S, Ferulano GP, Petitto M, Vanni L, Villari B, Di Lillo S, Fazio S, and Picilli M

Subjects
Adult, Aged, Drug Evaluation, Exercise Test, Female, Humans, Male, Middle Aged, Phosphocreatine therapeutic use, Plethysmography, Rheology, Arterial Occlusive Diseases drug therapy, Leg blood supply, Phosphocreatine analogs & derivatives
Published
1986

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