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Your search keyword '"Di Gianvincenzo, Paolo"' showing total 18 results
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18 results on '"Di Gianvincenzo, Paolo"'

6. Extracellular vesicles derived from mesenchymal stromal cells and red blood cells feature distinct biomolecular corona dynamics

Author

Musicò, Angelo, primary, Zendrini, Andrea, additional, Gimenez Reyes, Santiago, additional, Mangolini, Valentina, additional, Paolini, Lucia, additional, Romano, Miriam, additional, Papait, Andrea, additional, Silini, Antonietta Rosa, additional, Di Gianvincenzo, Paolo, additional, Neva, Arabella, additional, Cretich, Marina, additional, Parolini, Ornella, additional, Almici, Camillo, additional, Moya, Sergio, additional, Radeghieri, Annalisa, additional, and Bergese, Paolo, additional

Published
2024
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7. Biocompatible cellulose nanocrystal-based Trojan horse enables targeted delivery of nano-Au radiosensitizers to triple negative breast cancer cells.

Author

Biagiotti, Giacomo, Cazzoli, Riccardo, Andreozzi, Patrizia, Aresta, Giusi, Francesco, Mattii, Mangini, Chiara, di Gianvincenzo, Paolo, Tobia, Chiara, Recchia, Sandro, Polito, Laura, Severi, Mirko, Vittorio, Orazio, Cicchi, Stefano, Moya, Sergio E., Ronca, Roberto, Albini, Adriana, Berti, Debora, Orecchia, Roberto, Garibaldi, Cristina, and Minucci, Saverio

Published
2024
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18. Gold manno-glyconanoparticles for intervening in HIV gp120 carbohydrate-mediated processes.

Author

Di Gianvincenzo P, Chiodo F, Marradi M, and Penadés S

Subjects
Antibodies, Monoclonal chemistry, Antibodies, Neutralizing, Binding, Competitive, Broadly Neutralizing Antibodies, Carbohydrate Conformation, Carbohydrate Sequence, Cell Adhesion Molecules chemistry, Cell Adhesion Molecules metabolism, Gold pharmacology, HIV Antibodies, HIV Envelope Protein gp120 chemistry, HIV Fusion Inhibitors pharmacology, HIV-1 drug effects, HIV-1 immunology, HeLa Cells, Host-Pathogen Interactions, Humans, Lectins, C-Type chemistry, Lectins, C-Type metabolism, Metal Nanoparticles ultrastructure, Molecular Sequence Data, Oligosaccharides pharmacology, Particle Size, Protein Binding, Receptors, Cell Surface chemistry, Receptors, Cell Surface metabolism, Surface Plasmon Resonance, T-Lymphocytes drug effects, T-Lymphocytes metabolism, T-Lymphocytes virology, Titrimetry, Virus Internalization drug effects, Gold chemistry, HIV Envelope Protein gp120 physiology, HIV Fusion Inhibitors chemistry, HIV Infections prevention & control, HIV-1 physiology, Metal Nanoparticles chemistry, Oligosaccharides chemistry
Abstract

After nearly three decades since the discovery of human immunodeficiency virus (HIV) (1983), no effective vaccine or microbicide is available, and the virus continues to infect millions of people worldwide each year. HIV antiretroviral drugs reduce the death rate and improve the quality of life in infected patients, but they are not able to completely remove HIV from the body. The glycoprotein gp120, part of the envelope glycoprotein (Env) of HIV, is responsible for virus entry and infection of host cells. High-mannose type glycans that decorate gp120 are involved in different carbohydrate-mediated HIV binding. We have demonstrated that oligomannoside-coated gold nanoparticles (manno-GNPs) are able to interfere with HIV high-mannose glycan-mediated processes. In this chapter, we describe the methods for the preparation and characterization of manno-GNPs and the experiments performed by means of SPR and STD-NMR techniques to evaluate the ability of manno-GNPs to inhibit 2G12 antibody binding to gp120. The antibody 2G12-mediated HIV neutralization and the lectin DC-SIGN-mediated HIV trans-infection in cellular systems are also described., (Copyright © 2012 Elsevier Inc. All rights reserved.)

Published
2012
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