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208 results on '"Di Giannatale, Angela"'

1. Malignant peripheral nerve sheath tumor (MPNST) and MPNST-like entities are defined by a specific DNA methylation profile in pediatric and juvenile population

Author

Patrizi, Sara, Miele, Evelina, Falcone, Lorenza, Vallese, Silvia, Rossi, Sabrina, Barresi, Sabina, Giovannoni, Isabella, Pedace, Lucia, Nardini, Claudia, Masier, Ilaria, Abballe, Luana, Cacchione, Antonella, Russo, Ida, Di Giannatale, Angela, Di Ruscio, Valentina, Salgado, Claudia Maria, Mastronuzzi, Angela, Ciolfi, Andrea, Tartaglia, Marco, Milano, Giuseppe Maria, Locatelli, Franco, and Alaggio, Rita

Published
2024
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2. MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57Kip2 targeting

Author

Pomella, Silvia, Cassandri, Matteo, D’Archivio, Lucrezia, Porrazzo, Antonella, Cossetti, Cristina, Phelps, Doris, Perrone, Clara, Pezzella, Michele, Cardinale, Antonella, Wachtel, Marco, Aloisi, Sara, Milewski, David, Colletti, Marta, Sreenivas, Prethish, Walters, Zoë S., Barillari, Giovanni, Di Giannatale, Angela, Milano, Giuseppe Maria, De Stefanis, Cristiano, Alaggio, Rita, Rodriguez-Rodriguez, Sonia, Carlesso, Nadia, Vakoc, Christopher R., Velardi, Enrico, Schafer, Beat W., Guccione, Ernesto, Gatz, Susanne A., Wasti, Ajla, Yohe, Marielle, Ignatius, Myron, Quintarelli, Concetta, Shipley, Janet, Miele, Lucio, Khan, Javed, Houghton, Peter J., Marampon, Francesco, Gryder, Berkley E., De Angelis, Biagio, Locatelli, Franco, and Rota, Rossella

Published
2023
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3. Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas

Author

Pericoli, Giulia, Galardi, Angela, Paolini, Alessandro, Petrilli, Lucia Lisa, Pepe, Gerardo, Palma, Alessandro, Colletti, Marta, Ferretti, Roberta, Giorda, Ezio, Levi Mortera, Stefano, Burford, Anna, Carai, Andrea, Mastronuzzi, Angela, Mackay, Alan, Putignani, Lorenza, Jones, Chris, Pascucci, Luisa, Peinado, Hector, Helmer-Citterich, Manuela, de Billy, Emmanuel, Masotti, Andrea, Locatelli, Franco, Di Giannatale, Angela, and Vinci, Maria

Published
2023
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5. Case report: A safeguard in the sea of variants of uncertain significance: a case study on child with high risk neuroblastoma and acute myeloid leukemia

Author

Fabozzi, Francesco, primary, Carrozzo, Rosalba, additional, Lodi, Mariachiara, additional, Di Giannatale, Angela, additional, Cipri, Selene, additional, Rosignoli, Chiara, additional, Giovannoni, Isabella, additional, Stracuzzi, Alessandra, additional, Rizza, Teresa, additional, Montante, Claudio, additional, Agolini, Emanuele, additional, Di Nottia, Michela, additional, Galaverna, Federica, additional, Del Baldo, Giada, additional, Del Bufalo, Francesco, additional, Mastronuzzi, Angela, additional, and De Ioris, Maria Antonietta, additional

Published
2024
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6. Novel mediator in anaphylaxis: decreased levels of miR-375-3p in serum and within extracellular vesicles of patients

Author

Nuñez-Borque, Emilio, primary, Fernandez-Bravo, Sergio, additional, Rodríguez Del Rio, Pablo, additional, Palacio-García, Lucia, additional, Di Giannatale, Angela, additional, Di Paolo, Virginia, additional, Galardi, Angela, additional, Colletti, Marta, additional, Pascucci, Luisa, additional, Tome-Amat, Jaime, additional, Cuesta-Herranz, Javier, additional, Ibañez-Sandin, María Dolores, additional, Laguna, José Julio, additional, Benito-Martin, Alberto, additional, and Esteban, Vanesa, additional

Published
2023
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7. Tumour exosome integrins determine organotropic metastasis

Author

Hoshino, Ayuko, Costa-Silva, Bruno, Shen, Tang-Long, Rodrigues, Goncalo, Hashimoto, Ayako, Tesic Mark, Milica, Molina, Henrik, Kohsaka, Shinji, Di Giannatale, Angela, Ceder, Sophia, Singh, Swarnima, Williams, Caitlin, Soplop, Nadine, Uryu, Kunihiro, Pharmer, Lindsay, King, Tari, Bojmar, Linda, Davies, Alexander E, Ararso, Yonathan, Zhang, Tuo, Zhang, Haiying, Hernandez, Jonathan, Weiss, Joshua M, Dumont-Cole, Vanessa D, Kramer, Kimberly, Wexler, Leonard H, Narendran, Aru, Schwartz, Gary K, Healey, John H, Sandstrom, Per, Jørgen Labori, Knut, Kure, Elin H, Grandgenett, Paul M, Hollingsworth, Michael A, de Sousa, Maria, Kaur, Sukhwinder, Jain, Maneesh, Mallya, Kavita, Batra, Surinder K, Jarnagin, William R, Brady, Mary S, Fodstad, Oystein, Muller, Volkmar, Pantel, Klaus, Minn, Andy J, Bissell, Mina J, Garcia, Benjamin A, Kang, Yibin, Rajasekhar, Vinagolu K, Ghajar, Cyrus M, Matei, Irina, Peinado, Hector, Bromberg, Jacqueline, and Lyden, David

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Digestive Diseases, Cancer, Rare Diseases, Lung, Liver Disease, Aetiology, 2.1 Biological and endogenous factors, Animals, Biomarkers, Brain, Cell Line, Tumor, Endothelial Cells, Epithelial Cells, Exosomes, Female, Fibroblasts, Genes, src, Humans, Integrin alpha6beta1, Integrin alpha6beta4, Integrin beta Chains, Integrin beta4, Integrins, Kupffer Cells, Liver, Mice, Mice, Inbred C57BL, Neoplasm Metastasis, Organ Specificity, Phosphorylation, Receptors, Vitronectin, S100 Proteins, Tropism, General Science & Technology
Abstract

Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells. We show that tumour-derived exosomes uptaken by organ-specific cells prepare the pre-metastatic niche. Treatment with exosomes from lung-tropic models redirected the metastasis of bone-tropic tumour cells. Exosome proteomics revealed distinct integrin expression patterns, in which the exosomal integrins α6β4 and α6β1 were associated with lung metastasis, while exosomal integrin αvβ5 was linked to liver metastasis. Targeting the integrins α6β4 and αvβ5 decreased exosome uptake, as well as lung and liver metastasis, respectively. We demonstrate that exosome integrin uptake by resident cells activates Src phosphorylation and pro-inflammatory S100 gene expression. Finally, our clinical data indicate that exosomal integrins could be used to predict organ-specific metastasis.

Published
2015

9. Supplementary Data 3 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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10. Supplementary Data 2 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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11. Suppl. Figure 6 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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12. Suppl. Figure 5 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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13. Suppl. Figure 1 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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14. Supplementary Data 1 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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15. Suppl. Figure 4 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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16. Suppl. Figure 3 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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17. Data from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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18. Suppl. Figure 2 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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19. Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, additional, García-Silva, Susana, additional, Santos, Vanesa, additional, Sánchez-Redondo, Sara, additional, Savini, Claudia, additional, Graña-Castro, Osvaldo, additional, Blanco-Aparicio, Carmen, additional, Fischer, Suzanne, additional, De Wever, Olivier, additional, Creus-Bachiller, Edgar, additional, Ortega-Bertran, Sara, additional, Pisapia, David J., additional, Rodríguez-Peralto, Jose L., additional, Fernández-Rodríguez, Juana, additional, Pérez-Portabella, Cleofé Romagosa, additional, Alaggio, Rita, additional, Benassi, Maria Serena, additional, Pazzaglia, Laura, additional, Scotlandi, Katia, additional, Ratner, Nancy, additional, Yohay, Kaleb, additional, Theuer, Charles P., additional, and Peinado, Héctor, additional

Published
2023
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20. Desmoplastic small round cell tumor: from state of the art to future clinical prospects

Author

Hovsepyan, Shushan, primary, Giani, Claudia, additional, Pasquali, Sandro, additional, Di Giannatale, Angela, additional, Chiaravalli, Stefano, additional, Colombo, Chiara, additional, Orbach, Daniel, additional, Bergamaschi, Luca, additional, Vennarini, Sabina, additional, Gatz, Susanne Andrea, additional, Gasparini, Patrizia, additional, Berlanga, Pablo, additional, Casanova, Michela, additional, and Ferrari, Andrea, additional

Published
2023
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22. MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57Kip2 targeting.

Author

Pomella, Silvia, Cassandri, Matteo, D'Archivio, Lucrezia, Porrazzo, Antonella, Cossetti, Cristina, Phelps, Doris, Perrone, Clara, Pezzella, Michele, Cardinale, Antonella, Wachtel, Marco, Aloisi, Sara, Milewski, David, Colletti, Marta, Sreenivas, Prethish, Walters, Zoë S., Barillari, Giovanni, Di Giannatale, Angela, Milano, Giuseppe Maria, De Stefanis, Cristiano, and Alaggio, Rita

Subjects
RHABDOMYOSARCOMA, NEOPLASTIC cell transformation, TUMOR growth, CELL cycle
Abstract

Rhabdomyosarcomas (RMS) are pediatric mesenchymal-derived malignancies encompassing PAX3/7-FOXO1 Fusion Positive (FP)-RMS, and Fusion Negative (FN)-RMS with frequent RAS pathway mutations. RMS express the master myogenic transcription factor MYOD that, whilst essential for survival, cannot support differentiation. Here we discover SKP2, an oncogenic E3-ubiquitin ligase, as a critical pro-tumorigenic driver in FN-RMS. We show that SKP2 is overexpressed in RMS through the binding of MYOD to an intronic enhancer. SKP2 in FN-RMS promotes cell cycle progression and prevents differentiation by directly targeting p27Kip1 and p57Kip2, respectively. SKP2 depletion unlocks a partly MYOD-dependent myogenic transcriptional program and strongly affects stemness and tumorigenic features and prevents in vivo tumor growth. These effects are mirrored by the investigational NEDDylation inhibitor MLN4924. Results demonstrate a crucial crosstalk between transcriptional and post-translational mechanisms through the MYOD-SKP2 axis that contributes to tumorigenesis in FN-RMS. Finally, NEDDylation inhibition is identified as a potential therapeutic vulnerability in FN-RMS. SKP2 is an oncogenic E3-ubiquitin ligase. Here the authors show that SKP2 is epigenetically regulated by the muscle lineage transcription factor MYOD, supports tumorigenesis in the Fusion Negative (FN) subtype of rhabdomyosarcoma (RMS) and impairs differentiation promoting degradation of p57Kip2. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Pediatric BCOR-Altered Tumors From Soft Tissue/Kidney Display Specific DNA Methylation Profiles

Author

Salgado, Claudia M., primary, Alaggio, Rita, additional, Ciolfi, Andrea, additional, Zin, Angelica, additional, Diomedi Camassei, Francesca, additional, Pedace, Lucia, additional, Milano, Giuseppe Maria, additional, Serra, Annalisa, additional, Di Giannatale, Angela, additional, Mastronuzzi, Angela, additional, Gianatti, Andrea, additional, Bisogno, Gianni, additional, Ferrari, Andrea, additional, Tartaglia, Marco, additional, Reyes-Múgica, Miguel, additional, Locatelli, Franco, additional, and Miele, Evelina, additional

Published
2023
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26. Central Nervous System Metastasis in Neuroblastoma: From Three Decades Clinical Experience to New Considerations in the Immunotherapy Era

Author

Mastronuzzi, Angela, primary, Colafati, Giovanna Stefania, additional, Carai, Andrea, additional, D’Egidio, Maria, additional, Fabozzi, Francesco, additional, Del Bufalo, Francesca, additional, Villani, Maria Felicia, additional, Del Baldo, Giada, additional, Vennarini, Sabina, additional, Canino, Costanza, additional, Di Giannatale, Angela, additional, Tomà, Paolo, additional, Garganese, Maria Carmen, additional, and De Ioris, Maria Antonietta, additional

Published
2022
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27. Proteomics of Aqueous Humor as a Source of Disease Biomarkers in Retinoblastoma

Author

Galardi, Angela, primary, Stathopoulos, Christina, additional, Colletti, Marta, additional, Lavarello, Chiara, additional, Russo, Ida, additional, Cozza, Raffaele, additional, Romanzo, Antonino, additional, Carcaboso, Angel M., additional, Locatelli, Franco, additional, Petretto, Andrea, additional, Munier, Francis L., additional, and Di Giannatale, Angela, additional

Published
2022
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28. Molecular Characterization of Circulating Tumor DNA in Pediatric Rhabdomyosarcoma: A Feasibility Study

Author

Ruhen, Olivia, primary, Lak, Nathalie S.M., additional, Stutterheim, Janine, additional, Danielli, Sara G., additional, Chicard, Mathieu, additional, Iddir, Yasmine, additional, Saint-Charles, Alexandra, additional, Di Paolo, Virginia, additional, Tombolan, Lucia, additional, Gatz, Susanne A., additional, Aladowicz, Ewa, additional, Proszek, Paula, additional, Jamal, Sabri, additional, Stankunaite, Reda, additional, Hughes, Deborah, additional, Carter, Paul, additional, Izquierdo, Elisa, additional, Wasti, Ajla, additional, Chisholm, Julia C., additional, George, Sally L., additional, Pace, Erika, additional, Chesler, Louis, additional, Aerts, Isabelle, additional, Pierron, Gaelle, additional, Zaidi, Sakina, additional, Delattre, Olivier, additional, Surdez, Didier, additional, Kelsey, Anna, additional, Hubank, Michael, additional, Bonvini, Paolo, additional, Bisogno, Gianni, additional, Di Giannatale, Angela, additional, Schleiermacher, Gudrun, additional, Schäfer, Beat W., additional, Tytgat, Godelieve A.M., additional, and Shipley, Janet, additional

Published
2022
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29. Endoglin, a novel biomarker and therapeutical target to prevent malignant peripheral nerve sheath tumor growth and metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, additional, García-Silva, Susana, additional, Santos, Vanesa, additional, Sánchez-Redondo, Sara, additional, Savini, Claudia, additional, Graña-Castro, Osvaldo, additional, Blanco-Aparicio, Carmen, additional, Pisapia, David J, additional, Rodríguez-Peralto, Jose L, additional, Romagosa Pérez-Portabella, Cleofé, additional, Alaggio, Rita, additional, Benassi, Maria Serena, additional, Pazzaglia, Laura, additional, Scotlandi, Katia, additional, Ratner, Nancy, additional, Yohay, Kaleb, additional, Theuer, Charles P., additional, and Peinado, Héctor, additional

Published
2022
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31. MET Inhibition Sensitizes Rhabdomyosarcoma Cells to NOTCH Signaling Suppression

Author

Perrone, Clara, primary, Pomella, Silvia, additional, Cassandri, Matteo, additional, Pezzella, Michele, additional, Milano, Giuseppe Maria, additional, Colletti, Marta, additional, Cossetti, Cristina, additional, Pericoli, Giulia, additional, Di Giannatale, Angela, additional, de Billy, Emmanuel, additional, Vinci, Maria, additional, Petrini, Stefania, additional, Marampon, Francesco, additional, Quintarelli, Concetta, additional, Taulli, Riccardo, additional, Roma, Josep, additional, Gallego, Soledad, additional, Camero, Simona, additional, Mariottini, Paolo, additional, Cervelli, Manuela, additional, Maestro, Roberta, additional, Miele, Lucio, additional, De Angelis, Biagio, additional, Locatelli, Franco, additional, and Rota, Rossella, additional

Published
2022
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32. An Update on Circular RNA in Pediatric Cancers.

Author

Galardi, Angela, Colletti, Marta, Palma, Alessandro, and Di Giannatale, Angela

Subjects
CIRCULAR RNA, NEUROBLASTOMA, CHILDHOOD cancer, NON-coding RNA, PROGNOSIS, NEPHROBLASTOMA
Abstract

Circular RNAs (circRNAs) are a class of single-stranded closed noncoding RNA molecules which are formed as a result of reverse splicing of mRNAs. Despite their relative abundance, only recently there appeared an increased interest in the understanding of their regulatory importance. Among their most relevant characteristics are high stability, abundance and evolutionary conservation among species. CircRNAs are implicated in several cellular functions, ranging from miRNA and protein sponges to transcriptional modulation and splicing. Additionally, circRNAs' aberrant expression in pathological conditions is bringing to light their possible use as diagnostic and prognostic biomarkers. Their use as indicator molecules of pathological changes is also supported by their peculiar covalent closed cyclic structure which bestows resistance to RNases. Their regulatory role in cancer pathogenesis and metastasis is supported by studies involving human tumors that have investigated different expression profiles of these molecules. As endogenous competitive RNA, circRNAs can regulate tumor proliferation and invasion and they arouse great consideration as potential therapeutic biomarkers and targets for cancer. In this review, we describe the most recent findings on circRNAs in the most common pediatric solid cancers (such as brain tumors, neuroblastomas, and sarcomas) and in more rare ones (such as Wilms tumors, hepatoblastomas, and retinoblastomas). [ABSTRACT FROM AUTHOR]

Published
2023
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33. Tandem high-dose 131I-MIBG therapy supported by dosimetry in pediatric patients with relapsed-refractory high-risk neuroblastoma: the Bambino Gesu’ Children’s Hospital experience

Author

Altini, Claudio, primary, Villani, Maria F., additional, Di Giannatale, Angela, additional, Cassano, Bartolomeo, additional, Pizzoferro, Milena, additional, Serra, Annalisa, additional, Castellano, Aurora, additional, Cannatà, Vittorio, additional, and Garganese, Maria C., additional

Published
2021
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36. Establishment and Characterization of a Cell Line (S-RMS1) Derived from an Infantile Spindle Cell Rhabdomyosarcoma with SRF-NCOA2 Fusion Transcript

Author

Colletti, Marta, primary, Galardi, Angela, additional, Miele, Evelina, additional, Di Paolo, Virginia, additional, Russo, Ida, additional, De Stefanis, Cristiano, additional, De Vito, Rita, additional, Rinelli, Martina, additional, Ciolfi, Andrea, additional, De Angelis, Biagio, additional, Zin, Angelica, additional, Guffanti, Alessandro, additional, Digilio, Maria Cristina, additional, Novelli, Antonio, additional, Alaggio, Rita, additional, Milano, Giuseppe Maria, additional, and Di Giannatale, Angela, additional

Published
2021
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43. Integration of Multiple Platforms for the Analysis of Multifluorescent Marking Technology Applied to Pediatric GBM and DIPG

Author

Pericoli, Giulia, primary, Petrini, Stefania, additional, Giorda, Ezio, additional, Ferretti, Roberta, additional, Ajmone-Cat, Maria Antonietta, additional, Court, Will, additional, Conti, Libenzio Adrian, additional, De Simone, Roberta, additional, Bencivenga, Paola, additional, Palma, Alessia, additional, Di Giannatale, Angela, additional, Jones, Chris, additional, Carai, Andrea, additional, Mastronuzzi, Angela, additional, de Billy, Emmanuel, additional, Locatelli, Franco, additional, and Vinci, Maria, additional

Published
2020
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44. A Chart Review on the Feasibility and Safety of the Vincristine Irinotecan Pazopanib (VIPaz) Association in Children and Adolescents With Resistant or Relapsed Sarcomas

Author

Russo, Ida, primary, Di Paolo, Virginia, additional, Crocoli, Alessandro, additional, Mastronuzzi, Angela, additional, Serra, Annalisa, additional, Di Paolo, Pier Luigi, additional, Di Giannatale, Angela, additional, Miele, Evelina, additional, and Milano, Giuseppe Maria, additional

Published
2020
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45. Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

Author

Hoshino, Ayuko, primary, Kim, Han Sang, additional, Bojmar, Linda, additional, Gyan, Kofi Ennu, additional, Cioffi, Michele, additional, Hernandez, Jonathan, additional, Zambirinis, Constantinos P., additional, Rodrigues, Gonçalo, additional, Molina, Henrik, additional, Heissel, Søren, additional, Mark, Milica Tesic, additional, Steiner, Loïc, additional, Benito-Martin, Alberto, additional, Lucotti, Serena, additional, Di Giannatale, Angela, additional, Offer, Katharine, additional, Nakajima, Miho, additional, Williams, Caitlin, additional, Nogués, Laura, additional, Pelissier Vatter, Fanny A., additional, Hashimoto, Ayako, additional, Davies, Alexander E., additional, Freitas, Daniela, additional, Kenific, Candia M., additional, Ararso, Yonathan, additional, Buehring, Weston, additional, Lauritzen, Pernille, additional, Ogitani, Yusuke, additional, Sugiura, Kei, additional, Takahashi, Naoko, additional, Alečković, Maša, additional, Bailey, Kayleen A., additional, Jolissant, Joshua S., additional, Wang, Huajuan, additional, Harris, Ashton, additional, Schaeffer, L. Miles, additional, García-Santos, Guillermo, additional, Posner, Zoe, additional, Balachandran, Vinod P., additional, Khakoo, Yasmin, additional, Raju, G. Praveen, additional, Scherz, Avigdor, additional, Sagi, Irit, additional, Scherz-Shouval, Ruth, additional, Yarden, Yosef, additional, Oren, Moshe, additional, Malladi, Mahathi, additional, Petriccione, Mary, additional, De Braganca, Kevin C., additional, Donzelli, Maria, additional, Fischer, Cheryl, additional, Vitolano, Stephanie, additional, Wright, Geraldine P., additional, Ganshaw, Lee, additional, Marrano, Mariel, additional, Ahmed, Amina, additional, DeStefano, Joe, additional, Danzer, Enrico, additional, Roehrl, Michael H.A., additional, Lacayo, Norman J., additional, Vincent, Theresa C., additional, Weiser, Martin R., additional, Brady, Mary S., additional, Meyers, Paul A., additional, Wexler, Leonard H., additional, Ambati, Srikanth R., additional, Chou, Alexander J., additional, Slotkin, Emily K., additional, Modak, Shakeel, additional, Roberts, Stephen S., additional, Basu, Ellen M., additional, Diolaiti, Daniel, additional, Krantz, Benjamin A., additional, Cardoso, Fatima, additional, Simpson, Amber L., additional, Berger, Michael, additional, Rudin, Charles M., additional, Simeone, Diane M., additional, Jain, Maneesh, additional, Ghajar, Cyrus M., additional, Batra, Surinder K., additional, Stanger, Ben Z., additional, Bui, Jack, additional, Brown, Kristy A., additional, Rajasekhar, Vinagolu K., additional, Healey, John H., additional, de Sousa, Maria, additional, Kramer, Kim, additional, Sheth, Sujit, additional, Baisch, Jeanine, additional, Pascual, Virginia, additional, Heaton, Todd E., additional, La Quaglia, Michael P., additional, Pisapia, David J., additional, Schwartz, Robert, additional, Zhang, Haiying, additional, Liu, Yuan, additional, Shukla, Arti, additional, Blavier, Laurence, additional, DeClerck, Yves A., additional, LaBarge, Mark, additional, Bissell, Mina J., additional, Caffrey, Thomas C., additional, Grandgenett, Paul M., additional, Hollingsworth, Michael A., additional, Bromberg, Jacqueline, additional, Costa-Silva, Bruno, additional, Peinado, Hector, additional, Kang, Yibin, additional, Garcia, Benjamin A., additional, O’Reilly, Eileen M., additional, Kelsen, David, additional, Trippett, Tanya M., additional, Jones, David R., additional, Matei, Irina R., additional, Jarnagin, William R., additional, and Lyden, David, additional

Published
2020
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46. Proteomic Profiling of Retinoblastoma-Derived Exosomes Reveals Potential Biomarkers of Vitreous Seeding

Author

Galardi, Angela, primary, Colletti, Marta, additional, Lavarello, Chiara, additional, Di Paolo, Virginia, additional, Mascio, Paolo, additional, Russo, Ida, additional, Cozza, Raffaele, additional, Romanzo, Antonino, additional, Valente, Paola, additional, De Vito, Rita, additional, Pascucci, Luisa, additional, Peinado, Hector, additional, Carcaboso, Angel M., additional, Petretto, Andrea, additional, Locatelli, Franco, additional, and Di Giannatale, Angela, additional

Published
2020
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47. Neuroblastoma‐secreted exosomes carrying miR‐375 promote osteogenic differentiation of bone‐marrow mesenchymal stromal cells

Author

Colletti, Marta, primary, Tomao, Luigi, additional, Galardi, Angela, additional, Paolini, Alessandro, additional, Di Paolo, Virginia, additional, De Stefanis, Cristiano, additional, Mascio, Paolo, additional, Nazio, Francesca, additional, Petrini, Stefania, additional, Castellano, Aurora, additional, Russo, Ida, additional, Caruso, Roberta, additional, Piga, Simone, additional, De Vito, Rita, additional, Pascucci, Luisa, additional, Peinado, Hector, additional, Masotti, Andrea, additional, Locatelli, Franco, additional, and Di Giannatale, Angela, additional

Published
2020
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49. DNA Methylation Profiling for Diagnosing Undifferentiated Sarcoma with Capicua Transcriptional Receptor (CIC) Alterations

Author

Miele, Evelina, primary, De Vito, Rita, additional, Ciolfi, Andrea, additional, Pedace, Lucia, additional, Russo, Ida, additional, De Pasquale, Maria Debora, additional, Di Giannatale, Angela, additional, Crocoli, Alessandro, additional, Angelis, Biagio De, additional, Tartaglia, Marco, additional, Alaggio, Rita, additional, and Milano, Giuseppe Maria, additional

Published
2020
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50. Phase I study of vinblastine in combination with nilotinib in children, adolescents, and young adults with refractory or recurrent low-grade glioma

Author

Vairy, Stephanie, primary, Le Teuff, Gwénaël, primary, Bautista, Francisco, primary, De Carli, Emilie, primary, Bertozzi, Anne-Isabelle, primary, Pagnier, Anne, primary, Fouyssac, Fanny, primary, Nysom, Karsten, primary, Aerts, Isabelle, primary, Leblond, Pierre, primary, Millot, Frederic, primary, Berger, Claire, primary, Canale, Sandra, primary, Paci, Angelo, primary, Poinsignon, Vianney, primary, Chevance, Aurelie, primary, Ezzalfani, Monia, primary, Vidaud, Dominique, primary, Di Giannatale, Angela, primary, Hladun-Alvaro, Raquel, primary, Petit, Francois M, primary, Vassal, Gilles, primary, Geoerger, Birgit, primary, Le Deley, Marie-Cécile, primary, and Grill, Jacques, primary

Published
2020
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