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Purpose: To compare the effects between resisted sled sprint training (RSS) and unresisted sprint training (URS) on sprint and acceleration performance, vertical jump, and maximal strength during an 8-week period of preseason training. Methods: Twenty-six recreational active rugby players were randomly divided into either RSS or URS training groups and then performed 8 weeks of training, 2 sessions/wk of sprint-specific training program. The RSS group performed sprints by towing a sled overloaded with 12.6% of body mass for 2 of the 3 sets of 3 × 20-m sprints, plus one set was carried out with unresisted modality. The URS groups performed 3 sets of 3 × 20-m unresisted sprints. The measures of 10- and 30-m sprint times, vertical jump, and 3-repetition-maximum (3-RM) squat tests were performed at baseline and after 8 weeks. Results: Ten- and 30-m sprint times (P <.05 and η p 2 >.44) improved significantly more in RSS than in URS. Both groups improved significantly in vertical jump and 3-RM squat tests; however, no significant differences (P >.1 and η p 2 <.11) between groups were found. Conclusions: Our findings indicate that an 8-week program of RSS is more effective than URS for enhancing sprint time performance in male recreational active rugby players. In addition, these data suggest that a sled overload corresponding to 12.6% of body mass can induce positive effects on both acceleration and speed performance in recreational active rugby players. [ABSTRACT FROM AUTHOR]

Introduction: Post-acute sequelae of SARS-CoV-2 infection (PASC) presents a spectrum of symptoms following acute COVID-19, with exercise intolerance being a prevalent manifestation likely linked to disrupted oxygen metabolism and mitochondrial function. This study aims to assess maximal fat oxidation (MFO) and exercise intensity at MFO (FATmax) in distinct PASC subject groups and compare these findings with normative data. Methods: Eight male subjects with PASC were involved in this study. The participants were divided into two groups: "endurance-trained" subjects (VO2max > 55mL/min/kg) and "recreationally active" subjects (VO2max < 55 mL/min/kg). Each subject performed a graded exercise test until maximal oxygen consumption (VO2max) to measure fat oxidation. Subsequently, MFO was assessed, and FATmax was calculated as the ratio between VO2 at MFO and VO2 max. Results: The MFO and FATmax of "endurance-trained" subjects were 0.85, 0.89, 0.71, and 0.42 and 68%, 69%, 64%, and 53%, respectively. Three out of four subjects showed both MFO and FATmax values placed over the 80th percentile of normative data. The MFO and FATmax of "recreationally active" subjects were 0.34, 0.27, 0.35, and 0.38 and 47%, 39%, 43%, and 41%, respectively. All MFO and FATmax values of those subjects placed below the 20th percentile or between the 20th and 40th percentile. Discussion: Significant differences in MFO and FATmax values between 'endurance-trained' and "recreationally active" subjects suggest that specific endurance training, rather than simply an active lifestyle, may provide protective effects against alterations in mitochondrial function during exercise in subjects with PASC. [ABSTRACT FROM AUTHOR]

The proteinase inhibitor WSCI, active in inhibiting bacterial subtilisin and a number of animal chymotrypsins, was purified from endosperm of exaploid wheat (Triticum aestivum, c.v. San Pastore) by ion exchange chromatography and its complete amino acid sequence was established by automated Edman degradation. WSCI consists of a single polypeptide chain of 72 amino acid residues, has a molecular mass of 8126.3 Da and a pI of 5.8. The inhibition constants (K[subi]) for Bacillus licheniformis subtilisin and bovine pancreatic α-chymotrypsin are 3.92x10[sup-9] M and 7.24x10[sup-9] M, respectively. The inhibitor contains one methionine and of tryptophan residue and has a high content of essential amino acids (41 over a total of 72 residues), but no cysteines. The primary structure of WSCI shows high similarity with barley subtilisin-chymotrypsin isoinhibitors of the CI-2 type and with maize subtilisin-chymotrypsin inhibitor MPI. Significant degrees of similarity were also found between sequences of WSCI and of other members of the potato inhibitor I family of the serine proteinase inhibitors. The wheat inhibitor WSCI has a single reactive site (the peptide bond between methionyl-48 and glutamyl-49 residues) as identified by affinity chromatography and sequence analysis. [ABSTRACT FROM AUTHOR]