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2. Corrigendum to “Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy”

Author

Rossi, S., primary, Maisto, R., additional, Gesualdo, C., additional, Trotta, M. C., additional, Ferraraccio, F., additional, Kaneva, M. K., additional, Getting, S. J., additional, Surace, E., additional, Testa, F., additional, Simonelli, F., additional, Grieco, P., additional, Merlino, F., additional, Perretti, M., additional, D’Amico, M., additional, and Di Filippo, C., additional

Published
2021
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9. Arte sacra tra Rinascimento e Barocco

Author

Zambarbieri, A, Fonseca, CD, Alzati, C, Curzel, E, Andenna G., Dell'Omo, M, Pellegrini, L, Cociorgna, MT, Cortesi, M, Zardin, D, Di Filippo, C, Borromeo, A, Vaccaro, Luciano, Rovetta, Alessandro, Rovetta, Alessandro (ORCID:0000-0002-4167-7873), Zambarbieri, A, Fonseca, CD, Alzati, C, Curzel, E, Andenna G., Dell'Omo, M, Pellegrini, L, Cociorgna, MT, Cortesi, M, Zardin, D, Di Filippo, C, Borromeo, A, Vaccaro, Luciano, Rovetta, Alessandro, and Rovetta, Alessandro (ORCID:0000-0002-4167-7873)

Abstract

Sintetico percorso sulla produzione figurativa italiana tra Quattrocento e Seicento in riferimento ai principali avvenimenti e sviluppi religiosi

Published
2016

10. L'anoressia mentale: aspetti eziopatogenetici clinici e terapeutici

Author

MONTELEONE P, DI FILIPPO C, SCOGNAMIGLIO P, FABRAZZO, Michele, TORTORELLA, Alfonso Antonio Vincenzo, ZAPPIA V., FABRAZZO M., DI SAPIO M., DE BENEDETTA G., Monteleone, P, Tortorella, Alfonso Antonio Vincenzo, DI FILIPPO, C, Scognamiglio, P, and Fabrazzo, Michele

Published
2010

12. Polimorfismo 385C- A della FAAH nel Binge Eating Disorder

Author

TORTORELLA, Alfonso Antonio Vincenzo, MONTELEONE P, DI FILIPPO C, CANESTRELLI B, ESPOSITO G, MAJ M., Società Italiana di Psicopatologia, Tortorella, Alfonso Antonio Vincenzo, Monteleone, P, DI FILIPPO, C, Canestrelli, B, Esposito, G, and Maj, M.

Published
2009

16. Il ruolo dei fattori genetici nei disturbi del comportamento alimentare

Author

Monteleone, P, Tortorella, Alfonso Antonio Vincenzo, Castaldo, E, DI FILIPPO, C, Maj, M., Giornale italiano di Psicopatologia., Società Italiana di Psicopatologia, Monteleone, P, Tortorella, Alfonso Antonio Vincenzo, Castaldo, E, DI FILIPPO, C, and Maj, M.

Published
2008

17. The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme FAAH is associated with overweight/obesity but not with binge eating disorder in overweight/obese women

Author

MONTELEONE P., TORTORELLA A. A. V., MARTIADIS V., DI FILIPPO C., CANESTRELLI B., MAJ, Mario, Monteleone, P., Tortorella, A. A. V., Martiadis, V., DI FILIPPO, C., Canestrelli, B., and Maj, Mario

Subjects
obesity, FAAH gene, binge-eating disorder, endocannabinoid, polymorphisms
Abstract

Endocannabinoids are involved in the modulation of eating behavior; hence, alterations of this system may play a role in obesity. Recently, a single nucleotide polymorphism (cDNA 385C to A) of the gene coding for fatty acid amide hydrolase (FAAH), the major degrading enzyme of endocannabinoids, has been found to be associated with obesity. However, the possibility that the FAAH gene cDNA 385C to A single nucleotide polymorphism (SNP) is associated to binge eating disorder (BED), a condition that frequently occurs in obese individuals, has not been investigated. In order to address this issue, we assessed the distribution of the cDNA 385C to A SNP in 115 overweight/obese subjects with BED, 74 non-BED patients with obesity and 110 normal weight healthy controls. As compared to healthy controls, the whole group of overweight/obese BED and non-BED patients had a significantly higher frequency of the CA genotype and the A allele of the FAAH gene cDNA 385C to A SNP. Moreover, the SNP resulted significantly correlated to the presence of overweight/obesity (F(2, 296)=3.58, P=0.02), but not to the occurrence of BED (F(2, 296)=0.98; P=0.3). The present study confirms previously published significant over-representations of the FAAH 385 A allele in overweight/obese subjects and presents new data in BED patients that the 385 mutation is not significantly associated with BED-related obesity.

Published
2008

20. I disturbi del comportamento alimentare: Aspetti eziopatogenetici, clinici e terapeutici

Author

Monteleone, Palmiero, Castaldo, Eloisa, Di Filippo, C, Maj, M., Monteleone, P., Castaldo, E., Di Filippo, C., and Maj, M.

Subjects
Psychiatry, Eating disorders, therapy, Psychiatry and Mental Health, Eating disorders, diagnosi
Abstract

Anorexia nervosa (AN) and bulimia nervosa (BN) are characterised by pathological concerns about body weight (BW) and shape, which usually result in severe food restriction with BW loss in AN and binge-purging behaviours without weight loss in BN. The Diagnostic and Statistical Manual for Mental Disorders Test Revision (DSM-IV TR) includes in the category of eating disorders (EDs) also eating disorders not otherwise specified (EDNOS). EDNOS are represented by partial syndromes not fulfilling all the DSM-IV TR criteria for AN or BN, and by binge-eating disorder (BED), characterised by binge eating without purging or restrictive behaviours, which results in a dramatic BW increase. AN and BN are more prevalent in females than in males, and affect especially adolescents in the age range from 12 to 25 years. The etiopathogenesis of EDs is not known; it is widely believed that both biological, psychological and psychosocial factors contribute to their genesis and/or their maintenance. Among the biological factors, substances involved in the regulation of eating behaviour and energy homeostasis are thought to play a major role, as suggested by both genetic and biochemical studies. From a clinical point of view, AN may lead to severe medical complications, which are threatening for the patient's life; BN is rarely a life frightening condition; in the BED medical complications are similar to those of obesity. Both AN and BN have a high incidence of psychiatric comorbidity, especially affective and anxiety disorders and personality disorders. The treatment of these syndromes requires multiple interventions, which include drugs, psychotherapies, nutritional counselling, psychoeducation and treatment of medical complications. At present, no effective prevention is available.

Published
2006

22. Activation of Melanocortin Receptors MC1and MC5Attenuates Retinal Damage in Experimental Diabetic Retinopathy

Author

Rossi, S., primary, Maisto, R., additional, Gesualdo, C., additional, Trotta, M. C., additional, Ferraraccio, F., additional, Kaneva, M. K., additional, Getting, S. J., additional, Surace, E., additional, Testa, F., additional, Simonelli, F., additional, Grieco, P., additional, Merlino, F., additional, Perretti, M., additional, D’Amico, M., additional, and Di Filippo, C., additional

Published
2016
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24. 'The obese Etruscan'

Author

GIUGLIANO, Dario, MARFELLA R, NAPPO F, DI FILIPPO C, DE ANGELIS L, BERRINO, Liberato, ROSSI F, GIUGLIANO D., Giugliano, Dario, Marfella, R, Nappo, F, DI FILIPPO, C, DE ANGELIS, L, Berrino, Liberato, Rossi, F, and Giugliano, D.

Subjects
Male, Italy, Medicine in the Arts, Humans, Sculpture, Obesity, History, Ancient
Published
2001

29. Effects of High Glucose on QT Interval in Isolated Rat Heart

Author

MARFELLA, R., D'AMICO, M., NAPPO, F., DI FILIPPO, C., SINISCALCHI, M., ROSSI, F., and GIUGLIANO, D.

Subjects
Complications and side effects, Risk factors, Coronary heart disease -- Risk factors -- Complications and side effects, Hyperglycemia -- Complications and side effects -- Risk factors
Abstract

Prolongation of heart rate-adjusted QT (QTc) is associated with elevated risk of coronary heart disease and sudden death even in the diabetic patient. The objective of this study was to [...]

Published
2000

40. Inhibition of Ocular Aldose Reductase by a New Benzofuroxane Derivative Ameliorates Rat Endotoxic Uveitis

Author

Di Filippo, C., primary, Zippo, M. V., additional, Maisto, R., additional, Trotta, M. C., additional, Siniscalco, D., additional, Ferraro, B., additional, Ferraraccio, F., additional, La Motta, C., additional, Sartini, S., additional, Cosconati, S., additional, Novellino, E., additional, Gesualdo, C., additional, Simonelli, F., additional, Rossi, S., additional, and D’Amico, M., additional

Published
2014
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44. Effects of 5-perfluorophenyl/octyl/butyl-substituted derivatives of aromatic/heterocyclic sulfonamides on carbonic anhydrase II activity in vitro and on betamethasone-induced ocular hypertension in rabbits

Author

Di Filippo, C., Rossi, S., Lampa, E., Boldrini, E., Rinaldi, B., Falcone, G., Mazzeo, F., Filippelli, W., michele d'amico, DI FILIPPO, Clara, Rossi, Settimio, Lampa, E, Boldrini, E, Rinaldi, Barbara, Falcone, G, Mazzeo, F, Filippelli, W, and D'Amico, Michele

Subjects
5-perfluorophenyl/octyl/butyl-substituted compounds, Betamethasone, CAII inhibitors, Carbonic anhydrase, Conjunctival sac, Glaucoma, Hypotensive properties, Ocular hypertension, Sulfonamides
Published
2002

48. Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy.

Author

Rossi, S., Maisto, R., Gesualdo, C., Trotta, M. C., Ferraraccio, F., Kaneva, M. K., Getting, S. J., Surace, E., Testa, F., Simonelli, F., Grieco, P., Merlino, F., Perretti, M., D’Amico, M., and Di Filippo, C.

Subjects
MELANOCORTIN receptors, DIABETIC retinopathy, FLUORESCENCE angiography, PEPTIDOMIMETICS, GENE expression, LABORATORY mice, DIAGNOSIS
Abstract

We hypothesize that melanocortin receptors (MC) could activate tissue protective circuit in a model of streptozotocin- (STZ-) induced diabetic retinopathy (DR) in mice. At 12–16 weeks after diabetes induction, fluorescein angiography (FAG) revealed an approximate incidence of 80% microvascular changes, typical of DR, in the animals, without signs of vascular leakage. Occludin progressively decreased in the retina of mice developing retinopathy. qPCR of murine retina revealed expression of two MC receptors, Mc1r and Mc5r. The intravitreal injection (5 μL) of the selective MC1 small molecule agonist BMS-470539 (33 μmol) and the MC5 peptidomimetic agonist PG-901 (7.32 nM) elicited significant protection with regular course and caliber of retinal vessels, as quantified at weeks 12 and 16 after diabetes induction. Mouse retina homogenate settings indicated an augmented release of IL-1α, IL-1β, IL-6, MIP-1α, MIP-2α, MIP-3α, and VEGF from diabetic compared to nondiabetic mice. Application of PG20N or AGRP and MC5 and MC1 antagonist, respectively, augmented the release of cytokines, while the agonists BMS-470539 and PG-901 almost restored normal pattern of these mediators back to nondiabetic values. Similar changes were quantified with respect to Ki-67 staining. Finally, application of MC3-MC4 agonist/antagonists resulted to be inactive with respect to all parameters under assessment. [ABSTRACT FROM AUTHOR]

Published
2016
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