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1. Exposure to Gastric Acid Inhibitors Increases the Risk of Infection in Preterm Very Low Birth Weight Infants but Concomitant Administration of Lactoferrin Counteracts This Effect

Author

Di Comite, Amelia, Borghesi, Alessandro, Tzialla, Chryssoula, Agriesti, Giovanni, Arisio, Riccardo, Franco, Caterina, Guardione, Roberta, Boano, Elena, Catarinella, Alessia, Romano, Cristina, Monetti, Cesare, Sala, Ugo, Carbonara, Caterina, Mastretta, Emmanuele, Del Sordo, Paola, Priolo, Claudio, Galletto, Paolo, Campagnoli, Francesca, Vivalda, Mauro, Bonfante, Giuseppina, Gomirato, Giovanna, Montin, Davide, Camilla, Roberta, Messina, Alessandro, Pieretto, Marta, Cipolla, Domenico, Giuffrè, Mario, Corsello, Giovanni, Natale, Fabio, Vetrano, Gennaro, Tridapalli, Elisabetta, Faldella, Giacomo, Grazia Capretti, Maria, Paolillo, PierMichele, Picone, Simonetta, Lacerenza, Serafina, Gargano, Giancarlo, Magnani, Cristiana, Sergio Saia, Onofrio, Della Casa, Elena, Manzoni, Paolo, García Sánchez, Ruben, Meyer, Michael, Stolfi, Ilaria, Pugni, Lorenza, Messner, Hubert, Cattani, Silvia, Betta, Pasqua Maria, Memo, Luigi, Decembrino, Lidia, Bollani, Lina, Rinaldi, Matteo, Fioretti, Maria, Quercia, Michele, Maule, Milena, Tavella, Elena, Mussa, Alessandro, Laforgia, Nicola, Mosca, Fabio, Magaldi, Rosario, Mostert, Michael, and Farina, Daniele

Published
2018
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2. Impact of Whole Genome Sequencing to investigate transmission of Serratia marcescens in Neonatal Intensive Care Unit.

Author

Merla, Cristina, Ramus, Marina, Kuka, Angela, Mileto, Irene, Gaiarsa, Stefano, Di Comite, Amelia, Corbella, Marta, Piralla, Antonio, Lanave, Marina Liliana, Muzzi, Alba, Ghirardello, Stefano, Baldanti, Fausto, and Cambieri, Patrizia

Abstract

Newborns admitted to neonatal intensive care units (NICU) are at increased risk of health care-associated infections. Serratia marcescens represent the third most common pathogen in NICU outbreaks. Here we present an outbreak investigation performed using Whole Genome Sequencing (WGS) analyses and the control measures implemented to limit the spread of S. marcescens in the NICU of an Italian hospital. In February 2023 S. marcescens was isolated from six newborns, when in 2022 this pathogen was isolated only from two samples in the same ward. Measures for infection prevention were adopted. Routinary surveillance screening, performed with rectal swabs collected at admission and weekly thereafter, was implemented to search for S. marcescens presence. Environmental samples were collected. All the isolates, obtained from the conjunctival swab of six newborns, from rectal swab of two newborns who did not develop infections, as well as from the aerators of two faucets, were sequenced. WGS analyses showed no correlation between the isolates from newborns and environmental isolates. The implementation of the measures for infection prevention and control had enabled us to successfully control the outbreak within a short period. WGS analyses proved to be crucial in outbreak investigation to limit the spreading of the pathogens. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Fulminant echovirus 11 hepatitis in male non-identical twins in northern Italy, April 2023

Author

Piralla, Antonio, primary, Borghesi, Alessandro, additional, Di Comite, Amelia, additional, Giardina, Federica, additional, Ferrari, Guglielmo, additional, Zanette, Simona, additional, Figar, Tiziana Angelica, additional, Angelini, Micol, additional, Pisoni, Camilla, additional, Pitrolo, Antonino Maria Guglielmo, additional, Paolucci, Stefania, additional, Rovida, Francesca, additional, Pellicioli, Isabella, additional, Bonanomi, Ezio, additional, Baldanti, Fausto, additional, and Ghirardello, Stefano, additional

Published
2023
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6. Recommendations Concerning the First-Line Treatment of Children with Tuberculosis

Author

Principi, Nicola, Galli, Luisa, Lancella, Laura, Tadolini, Marina, Migliori, Giovanni Battista, Villani, Alberto, Esposito, Susanna, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, de Martino, Maurizio, Chiappini, Elena, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Guarino, Alfredo, Vecchio, Andrea Lo, Scotto, Riccardo, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, D'Ambrosio, Lia, Centis, Rosella, Cirillo, Daniela, Tortoli, Enrico, Pasinato, Angela, Russo, Cristina, Scaglione, Franco, Scala, Elisabetta, Tomà, Paolo, Bocchino, Marialuisa, Matteelli, Alberto, Scaglione, Francesco, LO VECCHIO, ANDREA, BOCCHINO, MARIALUISA, Principi, Nicola, Galli, Luisa, Lancella, Laura, Tadolini, Marina, Migliori, Giovanni Battista, Villani, Alberto, Esposito, Susanna, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, de Martino, Maurizio, Chiappini, Elena, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Guarino, Alfredo, Vecchio, Andrea Lo, Scotto, Riccardo, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, Bocchino, Marialuisa, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, D'Ambrosio, Lia, Centis, Rosella, Cirillo, Daniela, Tortoli, Enrico, Pasinato, Angela, Russo, Cristina, Scaglione, Franco, Scala, Elisabetta, Tomà, Paolo, Matteelli, Alberto, Scaglione, Francesco, LO VECCHIO, Andrea, For the Italian Pediatric TB Study Group, Null, and DI COMITE, Amelia

Subjects
0301 basic medicine, Pediatrics, medicine.medical_specialty, Tuberculosis, Tuberculosi, 030106 microbiology, Drug Resistance, Breastfeeding, Antitubercular Agents, Child, Drug Resistance, Microbial, Humans, Isoniazid, Medication Adherence, Tuberculosis, Pulmonary, Tuberculous meningitis, 03 medical and health sciences, Antitubercular Agent, Microbial, 0302 clinical medicine, Pharmacotherapy, 030225 pediatrics, medicine, Pharmacology (medical), Adverse effect, Ethambutol, Perinatology and Child Health, business.industry, Tuberculous pericarditis, Pulmonary, Pyrazinamide, medicine.disease, Settore MED/38, Surgery, Pediatrics, Perinatology and Child Health, business, medicine.drug, Human
Abstract

This document describes the recommendations of a group of scientific societies concerning the first-line therapeutic approach to paediatric tuberculosis (TB). The treatment of pulmonary TB should be based on the existence of parenchymal involvement and the risk of antibiotic resistance. The treatment of extra-pulmonary TB is based on the regimens used for severe pulmonary TB. The administration of corticosteroids is recommended only in cases of miliary TB, tuberculous meningitis and tuberculous pericarditis. Vitamin B6 may be indicated in the case of isoniazid-treated TB in breastfeeding infants, severely malnourished subjects, or patients with other diseases at high risk of vitamin deficiency. Once having started treatment, children with TB should be carefully followed up in order to evaluate compliance, the response to treatment, the need for treatment changes, and the presence of drug-related adverse events. Primary care paediatricians can support reference centres in providing family healthcare education and encouraging treatment compliance.

Published
2016

7. How to manage children who have come into contact with patients affected by tuberculosis

Author

Lancella, Laura, Vecchio, Andrea Lo, Chiappini, Elena, Tadolini, Marina, Cirillo, Daniela, Tortoli, Enrico, de Martino, Maurizio, Guarino, Alfredo, Principi, Nicola, Villani, Alberto, Esposito, Susanna, Galli, Luisa, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, Scotto, Riccardo, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Russo, Cristina, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, BOCCHINO, MARIALUISA, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, Matteelli, Alberto, Migliori, Giovanni Battista, Centis, Rossella, D'Ambrosio, Lia, Pasinato, Angela, Scaglione, Franco, Scala, Elisabetta, Tomà, Paolo, Lancella, Laura, Vecchio, Andrea Lo, Chiappini, Elena, Tadolini, Marina, Cirillo, Daniela, Tortoli, Enrico, de Martino, Maurizio, Guarino, Alfredo, Principi, Nicola, Villani, Alberto, Esposito, Susanna, Galli, Luisa, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, Scotto, Riccardo, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Russo, Cristina, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, Bocchino, Marialuisa, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, Matteelli, Alberto, Migliori, Giovanni Battista, Centis, Rossella, D'Ambrosio, Lia, Pasinato, Angela, Scaglione, Franco, Scala, Elisabetta, and Tomà, Paolo

Subjects
Pulmonary and Respiratory Medicine, Microbiology (medical), Pediatrics, medicine.medical_specialty, Tuberculosis, Contacts, Tuberculosi, IGRA, LTBI, Multidrug-resistant tuberculosis, Mycobacterium tuberculosis, Disease, Mycobacterium tuberculosi, Article, lcsh:Infectious and parasitic diseases, Molecular typing, Contact, Medicine, lcsh:RC109-216, Index case, lcsh:RC705-779, Immune status, biology, business.industry, Transmission (medicine), lcsh:Diseases of the respiratory system, biology.organism_classification, medicine.disease, Multidrug-resistant tuberculosi, Infectious Diseases, Chemoprophylaxis, Immunology, business
Abstract

Childhood tuberculosis (TB) indicates a recent infection, particularly in children aged

Published
2015

8. Exposure to Gastric Acid Inhibitors Increases the Risk of Infection in Preterm Very Low Birth Weight Infants but Concomitant Administration of Lactoferrin Counteracts This Effect

Author

Manzoni, Paolo, primary, García Sánchez, Ruben, additional, Meyer, Michael, additional, Stolfi, Ilaria, additional, Pugni, Lorenza, additional, Messner, Hubert, additional, Cattani, Silvia, additional, Betta, Pasqua Maria, additional, Memo, Luigi, additional, Decembrino, Lidia, additional, Bollani, Lina, additional, Rinaldi, Matteo, additional, Fioretti, Maria, additional, Quercia, Michele, additional, Maule, Milena, additional, Tavella, Elena, additional, Mussa, Alessandro, additional, Tzialla, Chryssoula, additional, Laforgia, Nicola, additional, Mosca, Fabio, additional, Magaldi, Rosario, additional, Mostert, Michael, additional, Farina, Daniele, additional, Di Comite, Amelia, additional, Borghesi, Alessandro, additional, Agriesti, Giovanni, additional, Arisio, Riccardo, additional, Franco, Caterina, additional, Guardione, Roberta, additional, Boano, Elena, additional, Catarinella, Alessia, additional, Romano, Cristina, additional, Monetti, Cesare, additional, Sala, Ugo, additional, Carbonara, Caterina, additional, Mastretta, Emmanuele, additional, Del Sordo, Paola, additional, Priolo, Claudio, additional, Galletto, Paolo, additional, Campagnoli, Francesca, additional, Vivalda, Mauro, additional, Bonfante, Giuseppina, additional, Gomirato, Giovanna, additional, Montin, Davide, additional, Camilla, Roberta, additional, Messina, Alessandro, additional, Pieretto, Marta, additional, Cipolla, Domenico, additional, Giuffrè, Mario, additional, Corsello, Giovanni, additional, Natale, Fabio, additional, Vetrano, Gennaro, additional, Tridapalli, Elisabetta, additional, Faldella, Giacomo, additional, Grazia Capretti, Maria, additional, Paolillo, PierMichele, additional, Picone, Simonetta, additional, Lacerenza, Serafina, additional, Gargano, Giancarlo, additional, Magnani, Cristiana, additional, Sergio Saia, Onofrio, additional, and Della Casa, Elena, additional

Published
2018
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9. Diagnostic Performance of Triggering Receptor Expressed on Myeloid Cells-1 and CD64 Index as Markers of Sepsis in Preterm Newborns

Author

Mazzucchelli, Iolanda, primary, Garofoli, Francesca, additional, Ciardelli, Laura, additional, Borghesi, Alessandro, additional, Tzialla, Chryssoulla, additional, Di Comite, Amelia, additional, Angelini, Micol, additional, Tinelli, Carmine, additional, Merlini, Giampaolo, additional, and Stronati, Mauro, additional

Published
2013
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11. Short-term and long-term sequelae in intrauterine growth retardation (IUGR).

Author

Longo, Stefania, Bollani, Lina, Decembrino, Lidia, Di Comite, Amelia, Angelini, Mauro, and Stronati, M.

Subjects
FETAL growth retardation, NEONATAL necrotizing enterocolitis, GESTATIONAL age, BODY temperature regulation, METABOLIC syndrome, DISEASE complications, RESPIRATORY distress syndrome
Abstract

Intrauterine Growth Retardation (IUGR) is defined as a rate of growth of a fetus that is less than normal for the growth potential of the fetus (for that particular gestational age). Small for Gestational Age (SGA) is defined infant born following IUGR, with a weight at birth below the 10th percentile.Suboptimal fetal growth occurring in IUGR fetuses is an important cause of perinatal mortality and morbidity. The acute neonatal consequences of IUGR include metabolic and hematological disturbances, and disrupted thermoregulation; in addition, respiratory distress (RDS), necrotizing enterocolitis (NEC), and retinopathy of prematurity (ROP) may contribute to perinatal morbidity. Metabolic disturbances are related to glucose and fatty acid metabolism. It is well-known that individuals who display poor growth in utero are at significantly increased risk for type 2 diabetes mellitus (T2DM), obesity, hypertension, dyslipidemia, and insulin resistance (the so-called metabolic syndrome, MS). MS ultimately leads to the premature development of cardiovascular diseases. In addition, short stature in children and adults, premature adrenarche, and the polycystic ovarian syndrome (PCOS) are endocrinological sequelae of IUGR. (8) Early onset growth delay and prematurity significantly increase the risk for neurological sequelae and motor and cognitive delay.Future prospective studies need to investigate risk factors for infants who are SGA. If reliable prediction can be achieved, there is potential to reduce future perinatal morbidity and mortality, and long term consequences among SGA babies. [ABSTRACT FROM AUTHOR]

Published
2013
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