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374 results on '"Di Bartolomeo, Paolo"'

1. Pegaspargase-modified risk-oriented program for adult acute lymphoblastic leukemia: results of the GIMEMA LAL1913 trial

Author

Bassan, Renato, Chiaretti, Sabina, Della Starza, Irene, Spinelli, Orietta, Santoro, Alessandra, Paoloni, Francesca, Messina, Monica, Elia, Loredana, De Propris, Maria Stefania, Scattolin, Anna Maria, Audisio, Ernesta, Marbello, Laura, Borlenghi, Erika, Zappasodi, Patrizia, Mauro, Elisa, Martinelli, Giovanni, Mattei, Daniele, Fracchiolla, Nicola, Bocchia, Monica, De Fabritiis, Paolo, Bonifacio, Massimiliano, Candoni, Anna, Cassibba, Vincenzo, Di Bartolomeo, Paolo, Latte, Giancarlo, Trappolini, Silvia, Guarini, Anna, Vitale, Antonella, Fazi, Paola, Piciocchi, Alfonso, Rambaldi, Alessandro, and Foà, Robin

Published
2023
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5. Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): a randomised, open-label, phase 3 trial

Author

Abildgaard, Niels, Adler, Howard, Altuntas, Fevzi, Akay, Olga Meltem, Amin, Bipinkumar, Anagnostopoulos, Achilleas, Anderson, Larry, Anttila, Pekka, Araujo, Carla, Arce-Lara, Carlos, Aydin, Yildiz, Basu, Supratik, Battini, Ramakrishna, Beeker, Thaddeus, Benboubker, Lotfi, Ben-Yehuda, Dina, Bladé, Joan, Blau, Igor Wolfgang, Boccia, Ralph, Burke, Lillian, Byeff, Peter, Cascavilla, Nicola, Cavo, Michele, Chantry, Andrew, Charles, Yen, Chaudhry, Arvind, Corso, Alessandro, Coyne, Mark, De Arriba, Felipe, Delimpasi, Sosana, Desjardins, Pierre, Dhakal, Binod, Di Bartolomeo, Paolo, Di Raimondo, Francesco, Dürig, Jan, Engelhardt, Monika, Escoffre-Barbe, Martine, Esteves, Graca, Flogegard, Max, Gabrail, Nashat, Gamberi, Barbara, Garrison, Mitchell, Gay, Julie, Gisslinger, Heinz, Goldschmidt, Hartmut, Goncalves, Cristina, Gressot, Laurent, Grosicki, Sebastian, Hanna, Wahid, Hayden, Patrick, Henriques Bernardo, Maria Manuela, Hermann, Robert, Holden, Viran, Honkalehto, Kirsti, Huben, Marianne, Huffman, John, Hunter, Hannah, Hus, Marek, Jagasia, Madan, Jagganath, Sundar, Janakiram, Murali, Jaiyesimi, Ishmael, Jenner, Matthew, João, Cristina, Johnson, Peter, Jurcyszyn, Artur, Kalayoğlu Beşişik, Sevgi, Kambhampati, Suman, Kanate, Abraham, Karadoğan, Ihsan, Khojasteh, Ali, Kirkel, Dean, Komarnicki, Mieczyslaw, Krauth, Maria-Theresa, Kuriakose, Phillip, Larocca, Alessandra, Lauri, Birgitta, Leleu, Xavier, Lucio, Paulo, Luppi, Mario, Mangiacavalli, Silvia, Mariette, Clara, Matsue, Kosei, Mellqvist, Ulf-Henri, Mendeleeva, Larisa, Meshad, Michael, Miller, Carole, Mohrbacher, Ann, Moreau, Philippe, Morelli, Anna Maria, Müldür, Ercan, Naassan, Anthony, Nahi, Hareth, Nair, Rajesh, O'Dwyer, Mike, Öngören Aydin, Seniz, Openshaw, Thomas, O'Rourke, Timothy, Osswald, Michael, Overton, Lindsay, Pati, Asmin, Pavic, Michel, Pegourie, Brigitte, Pehlivan, Mustafa, Pierola, Ana Alfonso, Plesner, Torben, Pluta, Andrzej, Rabin, Neil, Ramasamy, Karthik, Rambaldi, Alessandro, Rodriguez, Paula, Röllig, Christoph, Rosenblatt, Jacalyn, Rosenbluth, Jonathan, Salomo, Morten, Samoylova, Olga, Sastre Moral, Jose, Sati, Hamdi, Selleri, Carmine, Shafeek, Salim, Shinagawa, Atsushi, Sleckman, Bethany, Smith, Clay, Sonmez, Mehmet, Stone, Chester, Streetly, Matthew, Suzuki, Kenshi, Taetle, Raymond, Tafuri, Agostino, Takezako, Naoki, Teke, Hava Üsküdar, Vapaatalo, Mirja, Vassilopoulos, George, Verma, Amit, Vidito, Sarah, Viterbo, Luisa, Vural, Filiz, Wang, Xiang Sean, Yağci, Munci, Yee, Andrew, Richardson, Paul G, Oriol, Albert, Beksac, Meral, Liberati, Anna Marina, Galli, Monica, Schjesvold, Fredrik, Lindsay, Jindriska, Weisel, Katja, White, Darrell, Facon, Thierry, San Miguel, Jesus, Sunami, Kazutaka, O'Gorman, Peter, Sonneveld, Pieter, Robak, Pawel, Semochkin, Sergey, Schey, Steve, Yu, Xin, Doerr, Thomas, Bensmaine, Amine, Biyukov, Tsvetan, Peluso, Teresa, Zaki, Mohamed, Anderson, Kenneth, and Dimopoulos, Meletios

Published
2019
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7. Outcomes of Children with Hemophagocytic Lymphohistiocytosis Given Allogeneic Hematopoietic Stem Cell Transplantation in Italy

Author

Messina, Chiara, Zecca, Marco, Fagioli, Franca, Rovelli, Attilio, Giardino, Stefano, Merli, Pietro, Porta, Fulvio, Aricò, Maurizio, Sieni, Elena, Basso, Giuseppe, Ripaldi, Mimmo, Favre, Claudio, Pillon, Marta, Marzollo, Antonio, Rabusin, Marco, Cesaro, Simone, Algeri, Mattia, Caniglia, Maurizio, Di Bartolomeo, Paolo, Ziino, Ottavio, Saglio, Francesco, Prete, Arcangelo, and Locatelli, Franco

Published
2018
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8. Clinical-Grade–Expanded Regulatory T Cells Prevent Graft-versus-Host Disease While Allowing a Powerful T Cell–Dependent Graft-versus-Leukemia Effect in Murine Models

Author

Del Papa, Beatrice, Ruggeri, Loredana, Urbani, Elena, Baldoni, Stefano, Cecchini, Debora, Zei, Tiziana, Iacucci Ostini, Roberta, Crescenzi, Barbara, Carotti, Alessandra, Pierini, Antonio, Sportoletti, Paolo, Di Bartolomeo, Paolo, Falzetti, Franca, Mecucci, Cristina, Velardi, Andrea, Martelli, Massimo F., and Di Ianni, Mauro

Published
2017
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11. Transplant results in adults with Fanconi anaemia

Author

Bierings, Marc, Bonfim, Carmem, Peffault De Latour, Regis, Aljurf, Mahmoud, Mehta, Parinda A., Knol, Cora, Boulad, Farid, Tbakhi, Abdelghani, Esquirol, Albert, McQuaker, Grant, Sucak, Gulsan A., Othman, Tarek B., Halkes, Constantijn J. M., Carpenter, Ben, Niederwieser, Dietger, Zecca, Marco, Kröger, Nicolaus, Michallet, Mauricette, Risitano, Antonio M., Ehninger, Gerhard, Porcher, Raphael, Dufour, Carlo, Bonfirm, Carmem, Socié, Gerard, Gurman, Gunham, Ghavamzadeh, Ardesir, Hamladji, Rise‐Marie, van Lint, M.T., Stepensky, Polina, Koh, Mickey, Ozkurt, Zubeyde Nur, Veelken, Joan Hendrik, Bunjes, Donald, Beelen, Dietrich, Campos, Antonio, Robinson, Stephen, Alessandrino, E. Paolo, Unal, Ali, Fernandez Navarro, José Maria, Mufti, G.J., Velardi, Andrea, Passweg, Jakob, Apperley, Jane, Sengeloev, Henrik, Ljungman, Per, Foá, Roberto, Alegre, Adrián, Espiga, Carlos Richard, Cornelissen, J.J., Di Bartolomeo, Paolo, Cordonnier, Catherine, Browne, Paul, Jubert, Charlotte, Gastl, Günther, Pierelli, Luca, Johansson, Jan‐Erik, Fagioli, Franca, Moraleda, José, Zuckerman, Tsila, Bazarbachi, Ali, Sedlacek, Petr, Rössig, Claudia, Wynn, R.F., Hallek, Michael, Toren, Amos, Zudaire, Teresa, Clausen, Joahannes, Spencer, Andrew, Grazon Lopez, Sebastian, Schots, Rik, Komarnicki, M., González Muniz, Soledad, Vitek, Antonin, Rambaldi, Alessandro, Merli, Francesco, Rubio, Marie Thérese, Rossig, Claudia, Cabrera Marín, José Rafael, Porto, Fulvio, Kerre, Tessa, Metzner, Bernd, Stein, Jerry, Bertrand, Yves, Ciceri, Fabio, Chybicka, Alicja, Diez‐Martin, J.L., Bayoumy, Mohamed, de la Fuente, Josu, and Fegueux, Nathalie

Published
2018
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12. Haploidentical, unmanipulated, G-CSF–primed bone marrow transplantation for patients with high-risk hematologic malignancies

Author

Di Bartolomeo, Paolo, Santarone, Stella, De Angelis, Gottardo, Picardi, Alessandra, Cudillo, Laura, Cerretti, Raffaella, Adorno, Gaspare, Angelini, Stefano, Andreani, Marco, De Felice, Lidia, Rapanotti, Maria Cristina, Sarmati, Loredana, Bavaro, Pasqua, Papalinetti, Gabriele, Di Nicola, Marta, Papola, Franco, Montanari, Mauro, Nagler, Arnon, and Arcese, William

Published
2013
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13. Classifying Cytogenetics in Patients with Acute Myelogenous Leukemia in Complete Remission Undergoing Allogeneic Transplantation: A Center for International Blood and Marrow Transplant Research Study

Author

Armand, Philippe, Kim, Haesook T., Zhang, Mei-Jie, Perez, Waleska S., Dal Cin, Paola S., Klumpp, Thomas R., Waller, Edmund K., Litzow, Mark R., Liesveld, Jane L., Lazarus, Hillard M., Artz, Andrew S., Gupta, Vikas, Savani, Bipin N., McCarthy, Philip L., Cahn, Jean-Yves, Schouten, Harry C., Finke, Jürgen, Ball, Edward D., Aljurf, Mahmoud D., Cutler, Corey S., Rowe, Jacob M., Antin, Joseph H., Isola, Luis M., Di Bartolomeo, Paolo, Camitta, Bruce M., Miller, Alan M., Cairo, Mitchell S., Stockerl-Goldstein, Keith, Sierra, Jorge, Savoie, M. Lynn, Halter, Joerg, Stiff, Patrick J., Nabhan, Chadi, Jakubowski, Ann A., Bunjes, Donald W., Petersdorf, Effie W., Devine, Steven M., Maziarz, Richard T., Bornhauser, Martin, Lewis, Victor A., Marks, David I., Bredeson, Christopher N., Soiffer, Robert J., and Weisdorf, Daniel J.

Published
2012
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14. Efficacy, safety and feasibility of treatment of chronic HCV infection with directly acting agents in hematopoietic stem cell transplant recipients – Study of infectious diseases working party of EBMT

Author

Mikulska, Malgorzata, primary, Knelange, Nina, additional, Nicolini, Laura Ambra, additional, Tridello, Gloria, additional, Santarone, Stella, additional, Di Bartolomeo, Paolo, additional, de la Camara, Rafael, additional, Cuéllar, Clara, additional, Velardi, Andrea, additional, Perruccio, Katia, additional, Ljungman, Per, additional, Zaucha, Jan, additional, Piekarska, Agnieszka, additional, Basak, Grzegorz, additional, Karakulska-Prystupiuk, Ewa, additional, Angelucci, Emanuele, additional, Ciceri, Fabio, additional, Lupo-Stanghellini, Maria Teresa, additional, Fouillard, Loic, additional, García-Cadenas, Irene, additional, Menconi, Mariacristina, additional, Blau, Igor Wolfgang, additional, Nassi, Luca, additional, Cesaro, Simone, additional, and Styczynski, Jan, additional

Published
2022
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19. The graft-versus-leukemia effect using matched unrelated donors is not superior to HLA-identical siblings for hematopoietic stem cell transplantation

Author

Ringdén, Olle, Pavletic, Steven Z., Anasetti, Claudio, Barrett, A. John, Wang, Tao, Wang, Dan, Antin, Joseph H., Di Bartolomeo, Paolo, Bolwell, Brian J., Bredeson, Christopher, Cairo, Mitchell S., Gale, Robert P., Gupta, Vikas, Hahn, Theresa, Hale, Gregory A., Halter, Jorg, Jagasia, Madan, Litzow, Mark R., Locatelli, Franco, Marks, David I., McCarthy, Philip L., Cowan, Morton J., Petersdorf, Effie W., Russell, James A., Schiller, Gary J., Schouten, Harry, Spellman, Stephen, Verdonck, Leo F., Wingard, John R., Horowitz, Mary M., and Arora, Mukta

Published
2009
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20. A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: a risk factor analysis of outcomes for patients in remission at transplantation

Author

Ciceri, Fabio, Labopin, Myriam, Aversa, Franco, Rowe, Jakob M., Bunjes, Donald, Lewalle, Philippe, Nagler, Arnon, Di Bartolomeo, Paolo, Lacerda, João F., Lupo Stanghellini, Maria Teresa, Polge, Emmanuelle, Frassoni, Francesco, Martelli, Massimo F., and Rocha, Vanderson

Published
2008
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21. Expertsʼ considerations on HLA-haploidentical stem cell transplantation

Author

Patriarca, Francesca, Luznik, Leo, Medeot, Marta, Zecca, Marco, Bacigalupo, Andrea, Di Bartolomeo, Paolo, Arcese, William, Corradini, Paolo, Ciceri, Fabio, Vago, Luca, Kanakry, Christopher G., Fleischhauer, Katharina, Martelli, Massimo F., Bosi, Alberto, Rambaldi, Alessandro, Cesaro, Simone, Russo, Domenico, and Fanin, Renato

Published
2014
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24. The OGS–Northeastern Italy Seismic and Deformation Network: Current Status and Outlook

Author

Bragato, Pier Luigi, primary, Comelli, Paolo, additional, Saraò, Angela, additional, Zuliani, David, additional, Moratto, Luca, additional, Poggi, Valerio, additional, Rossi, Giuliana, additional, Scaini, Chiara, additional, Sugan, Monica, additional, Barnaba, Carla, additional, Bernardi, Paolo, additional, Bertoni, Michele, additional, Bressan, Gianni, additional, Compagno, Alessio, additional, Del Negro, Elvio, additional, Di Bartolomeo, Paolo, additional, Fabris, Paolo, additional, Garbin, Marco, additional, Grossi, Maurizio, additional, Magrin, Andrea, additional, Magrin, Enrico, additional, Pesaresi, Damiano, additional, Petrovic, Bojana, additional, Linares, Milton Percy Plasencia, additional, Romanelli, Marco, additional, Snidarcig, Adriano, additional, Tunini, Lavinia, additional, Urban, Sandro, additional, Venturini, Elisa, additional, and Parolai, Stefano, additional

Published
2021
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26. Thymoglobulin Prevents Chronic Graft-versus-Host Disease, Chronic Lung Dysfunction, and Late Transplant-Related Mortality: Long-Term Follow-Up of a Randomized Trial in Patients Undergoing Unrelated Donor Transplantation

Author

Bacigalupo, Andrea, Lamparelli, Teresa, Barisione, Giovanni, Bruzzi, Paolo, Guidi, Stefano, Alessandrino, Paolo Emilio, di Bartolomeo, Paolo, Oneto, Rosi, Bruno, Barbara, Sacchi, Nicoletta, van Lint, Maria Teresa, and Bosi, Alberto

Published
2006
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28. Dasatinib–Blinatumomab for Ph-Positive Acute Lymphoblastic Leukemia in Adults

Author

Foà, Robin, primary, Bassan, Renato, additional, Vitale, Antonella, additional, Elia, Loredana, additional, Piciocchi, Alfonso, additional, Puzzolo, Maria-Cristina, additional, Canichella, Martina, additional, Viero, Piera, additional, Ferrara, Felicetto, additional, Lunghi, Monia, additional, Fabbiano, Francesco, additional, Bonifacio, Massimiliano, additional, Fracchiolla, Nicola, additional, Di Bartolomeo, Paolo, additional, Mancino, Alessandra, additional, De Propris, Maria-Stefania, additional, Vignetti, Marco, additional, Guarini, Anna, additional, Rambaldi, Alessandro, additional, and Chiaretti, Sabina, additional

Published
2020
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29. Adoptive Immunotherapy with Regulatory and Conventional T Cells in Haploidentical Transplantation Primes Dendritic Cells to Promote T Cell Alloreactivity in the Bone Marrow and Tolerance in the Periphery

Author

Di Ianni, Mauro, primary, Giancola, Raffaella, additional, Baldoni, Stefano, additional, Ulbar, Francesca, additional, Del Papa, Beatrice, additional, Santarone, Stella, additional, Natale, Annalisa, additional, Olioso, Paola, additional, Di Bartolomeo, Paolo, additional, Bonfini, Tiziana, additional, Accorsi, Patrizia, additional, Sportoletti, Paolo, additional, Carotti, Alessandra, additional, Pierini, Antonio, additional, Ruggeri, Loredana, additional, Falzetti, Franca, additional, Martelli, Massimo Fabrizio, additional, and Velardi, Andrea, additional

Published
2019
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33. Family Mismatched Allogeneic Stem Cell Transplantation for Myelofibrosis : Report from the Chronic Malignancies Working Party of European Society for Blood and Marrow Transplantation

Author

Raj, Kavita, Eikema, Diderik-Jan, McLornanl, Donal P., Olavarria, Eduardo, Bloke, Henric-Jan, Bregante, Stefania, Ciceri, Fabio, Passweg, Jakob, Ljungman, Per, Schaap, Nicolaas, Carlson, Kristina, Zuckerman, Tsila, de Wreede, Liesbeth C., Volin, Liisa, Koc, Yener, Luis Diez-Martin, Jose, Brossart, Peter, Wolf, Dominik, Blaise, Didier, Di Bartolomeo, Paolo, Vitek, Antonin, Robin, Marie, Yakoub-Agha, Ibrahim, Chalandon, Yves, Kroger, Nicolaus, Raj, Kavita, Eikema, Diderik-Jan, McLornanl, Donal P., Olavarria, Eduardo, Bloke, Henric-Jan, Bregante, Stefania, Ciceri, Fabio, Passweg, Jakob, Ljungman, Per, Schaap, Nicolaas, Carlson, Kristina, Zuckerman, Tsila, de Wreede, Liesbeth C., Volin, Liisa, Koc, Yener, Luis Diez-Martin, Jose, Brossart, Peter, Wolf, Dominik, Blaise, Didier, Di Bartolomeo, Paolo, Vitek, Antonin, Robin, Marie, Yakoub-Agha, Ibrahim, Chalandon, Yves, and Kroger, Nicolaus

Abstract

This analysis included 56 myelofibrosis (MF) patients transplanted from family mismatched donor between 2009 and 2015 enrolled in the European Society for Blood and Marrow Transplantation database. The median age was 57 years (range, 38 to 72); 75% had primary MF and 25% had secondary MF. JAK2 V617F was mutated in 61%. Donors were HLA mismatched at 2 or more loci. Stem cells were sourced from bone marrow in 66% and peripheral blood in 34%. The median CD34(+) cell dose was 4.8 x 10(6)/kg (range, 1.7 to 22.9; n = 43). Conditioning was predominantly myeloablative in 70% and reduced intensity in the remainder. Regimens were heterogeneous with thiotepa, busulfan, fludarabine, and post-transplant cyclophosphamide used in 59%. The incidence of neutrophil engraftment by 28 days was 82% (range, 70% to 93%), at a median of 21 days (range, 19 to 23). At 2 years the cumulative incidence of primary graft failure was 9% (95% CI 1% to 16%) and secondary graft failure was 13% (95% CI 4% to 22%). The cumulative incidence of acute graft-versus-host disease (GVHD) grades II to IV and Ill to IV was 28% (95% CI 16% to 40%) and 9% (95% CI 2% to 17%) at 100 days. The cumulative incidence of chronic GVHD at 1 year was 45% (95% CI 32% to 58%), but the cumulative incidence of death without chronic GVHD by 1 year was 20% (95% CI 10% to 31%). With a median follow-up of 32 months, the 1- and 2-year overall survival was 61% (95% CI 48% to 74%) and 56% (95% CI 41% to 70%), respectively. The 1- and 2- year progression-free survival was 58% (95% CI 45% to 71%) and 43% (95% CI 28% to 58%), respectively, with a 2-year cumulative incidence of relapse of 19% 95% CI 7% to 31%). The 2-year nonrelapse mortality was 38% (95% CI 24% to 51%). This retrospective study of MF allo-SCT using family mismatched donors demonstrated feasibility of the approach, timely neutrophil engraftment in over 80% of cases, and acceptable overall and progression-free survival rates with relapse rates not dissimilar to the unrel

Published
2019
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34. Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia After Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey

Author

Girmenia, Corrado, Bertaina, Alice, Piciocchi, Alfonso, Perruccio, Katia, Algarotti, Alessandra, Busca, Alessandro, Cattaneo, Chiara, Raiola, Anna Maria, Guidi, Stefano, Iori, Anna Paola, Candoni, Anna, Irrera, Giuseppe, Milone, Giuseppe, Marcacci, Giampaolo, Scimè, Rosanna, Musso, Maurizio, Cudillo, Laura, Sica, Simona, Castagna, Luca, Corradini, Paolo, Marchesi, Francesco, Pastore, Domenico, Alessandrino, Emilio Paolo, Annaloro, Claudio, Ciceri, Fabio, Santarone, Stella, Nassi, Luca, Farina, Claudio, Viscoli, Claudio, Rossolini, Gian Maria, Bonifazi, Francesca, Rambaldi, Alessandro, Capria, Saveria, Bertaina, A., Mastronuzzi, Angela, Pagliara, Daria, Bernaschi, Paola, Amico, Lucia, Carotti, Alessandra, Mencacci, Antonella, Busca, A., Bruno, Benedetto, Costa, Cristina, Passi, Angela, Ravizzola, Giuseppe, Angelucci, Emanuele, Marchese, Anna, Pecile, Patrizia, Candoni, A., Ventura, Giovanna, Fanin, Renato, Scarparo, Claudio, Barbaro, Angelo, Milone, G., Leotta, Salvatore, Marchese, Anna Elisa, Marcacci, G., Becchimanzi, Cristina, Donnarumma, Daniela, Tringali, Stefania, Baldi, Maria Teresa, Scalone, Renato, Cudillo, L., Picardi, Alessandra, Arcese, William, Fontana, Carla, Sica, S., Giammarco, Sabrina, Spanu, Teresa, Castagna, L., Crocchiolo, Roberto, Casari, Erminia, Mussetti, Alberto, Conte, Eutilia, Ensoli, Fabrizio, Miragliotta, Giuseppe, Marone, Piero, Arghittu, Milena, Greco, Raffaella, Forcina, Alessandra, Chichero, Paola, Santarone, S., Di Bartolomeo, Paolo, Fazii, Paolo, Kroumova, Vesselina, Decembrino, Nunzia, Zecca, Marco, Pisapia, Giovanni, Palazzo, Giulia, Lanino, Edoardo, Faraci, Maura, Castagnola, Elio, Bandettini, Roberto, Pastano, Rocco, Sammassimo, Simona, Passerini, Rita, Stefani, Piero Maria, Gherlinzoni, Filippo, Rigoli, Roberto, Prezioso, Lucia, Cambò, Benedetta, Calderaro, Adriana, Carella, Angelo Michele, Cascavilla, Nicola, Labonia, Maria Teresa, Celeghini, Ivana, Mordini, Nicola, Piana, Federica, Vacca, Adriana, Sanna, Marco, Podda, Giovanni, Corsetti, Maria Teresa, Rocchetti, Andrea, Cilloni, Daniela, De Gobbi, Marco, Bianco, Ornella, Fagioli, Franca, Carraro, Francesca, De Intinis, Gianfranco, Severino, Alessandro, Proia, Anna, Parisi, Gabriella, Vallisa, Daniele, Confalonieri, Massimo, Russo, Domenico, Malagola, Michele, Galieni, Piero, Falcioni, Sadia, Travaglini, Valeria, Raimondi, Roberto, Borghero, Carlo, Pavan, Giacomina, Prete, Arcangelo, Belotti, Tamara, Ambretti, Simone, Imola, Manuela, Mianulli, Anna Maria, Pedna, Maria Federica, Cesaro, Simone, Lo Cascio, Giuliana, Ferrari, Antonella, Piedimonte, Monica, Santino, Iolanda, Calandrelli, Monica, Olivieri, Attilio, Orecchioni, Francesca, Mirabile, Milena, Centurioni, Riccardo, Gironacci, Luciana, Caravelli, Daniela, Gallo, Susanna, De Filippi, Marco, Cupelli, Luca, Dentamaro, Teresa, Falco, Silvana, Eugenio, Ospedale S, Marotta, Serena, Risitano, Antonio, Lula, Dora, Musto, Pellegrino, Pietrantuono, Giuseppe, Traficante, Antonio, Cerchiara, Elisabetta, Tirindelli, Maria Cristina, Dicuonzo, Giordano, Chierichini, Anna, Anaclerico, Barbara, Placanica, Paola, Girmenia, C, Bertaina, A, Piciocchi, A, Perruccio, K, Algarotti, A, Busca, A, Cattaneo, C, Raiola, Am, Guidi, S, Iori, Ap, Candoni, A, Irrera, G, Milone, G, Marcacci, G, Scimè, R, Musso, M, Cudillo, L, Sica, S, Castagna, L, Corradini, P, Marchesi, F, Pastore, D, Alessandrino, Ep, Annaloro, C, Ciceri, F, Santarone, S, Nassi, L, Farina, C, Viscoli, C, Rossolini, Gm, Bonifazi, F, Rambaldi, A, for the Gruppo Italiano Trapianto di Midollo Osseo, (GITMO), Associazione Microbiologi Clinici Italiani, (AMCLI), Girmenia, Corrado, Bertaina, Alice, Piciocchi, Alfonso, Perruccio, Katia, Algarotti, Alessandra, Busca, Alessandro, Cattaneo, Chiara, Raiola, Anna Maria, Guidi, Stefano, Iori, Anna Paola, Candoni, Anna, Irrera, Giuseppe, Milone, G., Marcacci, Giampaolo, Scimè, Rosanna, Musso, Maurizio, Cudillo, Laura, Sica, Simona, Castagna, Luca, Corradini, Paolo, Marchesi, Francesco, Pastore, Domenico, Alessandrino, Emilio Paolo, Annaloro, Claudio, Ciceri, Fabio, Santarone, Stella, Nassi, Luca, Farina, Claudio, Viscoli, Claudio, Rossolini, Gian Maria, Bonifazi, Francesca, Rambaldi, Alessandro, Capria, Saveria, Bertaina, A., Mastronuzzi, Angela, Pagliara, Daria, Bernaschi, Paola, Amico, Lucia, Carotti, Alessandra, Mencacci, Antonella, Busca, A., Bruno, Benedetto, Costa, Cristina, Passi, Angela, Ravizzola, Giuseppe, Angelucci, Emanuele, Marchese, Anna, Pecile, Patrizia, Candoni, A., Ventura, Giovanna, Fanin, Renato, Scarparo, Claudio, Barbaro, Angelo, Leotta, Salvatore, Marchese, Anna Elisa, Marcacci, G., Becchimanzi, Cristina, Donnarumma, Daniela, Tringali, Stefania, Baldi, Maria Teresa, Scalone, Renato, Cudillo, L., Picardi, Alessandra, Arcese, William, Fontana, Carla, Sica, S., Giammarco, Sabrina, Spanu, Teresa, Castagna, L., Crocchiolo, Roberto, Casari, Erminia, Mussetti, Alberto, Conte, Eutilia, Ensoli, Fabrizio, Miragliotta, Giuseppe, Marone, Piero, Arghittu, Milena, Greco, Raffaella, Forcina, Alessandra, Chichero, Paola, Santarone, S., Di Bartolomeo, Paolo, Fazii, Paolo, Kroumova, Vesselina, Decembrino, Nunzia, Zecca, Marco, Pisapia, Giovanni, Palazzo, Giulia, Lanino, Edoardo, Faraci, Maura, Castagnola, Elio, Bandettini, Roberto, Pastano, Rocco, Sammassimo, Simona, Passerini, Rita, Stefani, Piero Maria, Gherlinzoni, Filippo, Rigoli, Roberto, Prezioso, Lucia, Cambò, Benedetta, Calderaro, Adriana, Carella, Angelo Michele, Cascavilla, Nicola, Labonia, Maria Teresa, Celeghini, Ivana, Mordini, Nicola, Piana, Federica, Vacca, Adriana, Sanna, Marco, Podda, Giovanni, Corsetti, Maria Teresa, Rocchetti, Andrea, Cilloni, Daniela, De Gobbi, Marco, Bianco, Ornella, Fagioli, Franca, Carraro, Francesca, De Intinis, Gianfranco, Severino, Alessandro, Proia, Anna, Parisi, Gabriella, Vallisa, Daniele, Confalonieri, Massimo, Russo, Domenico, Malagola, Michele, Galieni, Piero, Falcioni, Sadia, Travaglini, Valeria, Raimondi, Roberto, Borghero, Carlo, Pavan, Giacomina, Prete, Arcangelo, Belotti, Tamara, Ambretti, Simone, Imola, Manuela, Mianulli, Anna Maria, Pedna, Maria Federica, Cesaro, Simone, Lo Cascio, Giuliana, Ferrari, Antonella, Piedimonte, Monica, Santino, Iolanda, Calandrelli, Monica, Olivieri, Attilio, Orecchioni, Francesca, Mirabile, Milena, Centurioni, Riccardo, Gironacci, Luciana, Caravelli, Daniela, Gallo, Susanna, De Filippi, Marco, Cupelli, Luca, Dentamaro, Teresa, Falco, Silvana, Eugenio, Ospedale S, Marotta, Serena, Risitano, Antonio, Lula, Dora, Musto, Pellegrino, Pietrantuono, Giuseppe, Traficante, Antonio, Cerchiara, Elisabetta, Tirindelli, Maria Cristina, Dicuonzo, Giordano, Chierichini, Anna, Anaclerico, Barbara, and Placanica, Paola

Subjects
0301 basic medicine, Male, Transplantation Conditioning, Drug Resistance, Bacteremia, 0302 clinical medicine, epidemiology, Gram negative bacteremia, multidrug resistance, stem cell transplant, survival, Risk Factors, Drug Resistance, Multiple, Bacterial, Epidemiology, Medicine, Age Factor, Prospective Studies, Prospective cohort study, Child, Transplantation, Homologou, education.field_of_study, Incidence (epidemiology), Incidence, Bacterial, Age Factors, Hematopoietic Stem Cell Transplantation, Middle Aged, Transplantation, Autologou, surgical procedures, operative, Infectious Diseases, Italy, Child, Preschool, Female, medicine.symptom, Multiple, Autologous, Human, Homologous, Microbiology (medical), Adult, medicine.medical_specialty, Adolescent, 030106 microbiology, Population, Transplantation, Autologous, 03 medical and health sciences, Young Adult, Internal medicine, Gram-Negative Bacteria, Gram-Negative Bacterial Infection, Escherichia coli, Humans, Transplantation, Homologous, Preschool, education, Aged, Gram-Negative Bacterial Infections, Infant, Transplantation, business.industry, Risk Factor, medicine.disease, Prospective Studie, Carriage, Otitis, business, Settore MED/15 - Malattie del Sangue, 030215 immunology
Abstract

Background Gram-negative bacteremia (GNB) is a major cause of illness and death after hematopoietic stem cell transplantation (HSCT), and updated epidemiological investigation is advisable. Methods We prospectively evaluated the epidemiology of pre-engraftment GNB in 1118 allogeneic HSCTs (allo-HSCTs) and 1625 autologous HSCTs (auto-HSCTs) among 54 transplant centers during 2014 (SIGNB-GITMO-AMCLI study). Using logistic regression methods. we identified risk factors for GNB and evaluated the impact of GNB on the 4-month overall-survival after transplant. Results The cumulative incidence of pre-engraftment GNB was 17.3% in allo-HSCT and 9% in auto-HSCT. Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the most common isolates. By multivariate analysis, variables associated with GNB were a diagnosis of acute leukemia, a transplant from a HLA-mismatched donor and from cord blood, older age, and duration of severe neutropenia in allo-HSCT, and a diagnosis of lymphoma, older age, and no antibacterial prophylaxis in auto-HSCT. A pretransplant infection by a resistant pathogen was significantly associated with an increased risk of posttransplant infection by the same microorganism in allo-HSCT. Colonization by resistant gram-negative bacteria was significantly associated with an increased rate of infection by the same pathogen in both transplant procedures. GNB was independently associated with increased mortality at 4 months both in allo-HSCT (hazard ratio, 2.13; 95% confidence interval, 1.45–3.13; P Conclusions Pre-engraftment GNB is an independent factor associated with increased mortality rate at 4 months after auto-HSCT and allo-HSCT. Previous infectious history and colonization monitoring represent major indicators of GNB. Clinical Trials registration NCT02088840.

Published
2017

35. Stem cell transplantation from HLA-matched related donor for Fanconiʼs anaemia: a retrospective review of the multicentric Italian experience on behalf of Associazione Italiana di Ematologia ed Oncologia Pediatrica (AIEOP)–Gruppo Italiano Trapianto di Midollo Osseo (GITMO)

Author

Dufour, Carlo, Rondelli, Roberto, Locatelli, Franco, Miano, Maurizio, Di Girolamo, Gabriele, Bacigalupo, Andrea, Messina, Chiara, Porta, Fulvio, Balduzzi, Adriana, Iorio, Anna Paola, Buket, Erer, Madon, Enrico, Pession, Andrea, Dini, Giorgio, and Di Bartolomeo, Paolo

Published
2001

36. Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): a randomised, open-label, phase 3 trial

Author

Richardson, Paul G, primary, Oriol, Albert, additional, Beksac, Meral, additional, Liberati, Anna Marina, additional, Galli, Monica, additional, Schjesvold, Fredrik, additional, Lindsay, Jindriska, additional, Weisel, Katja, additional, White, Darrell, additional, Facon, Thierry, additional, San Miguel, Jesus, additional, Sunami, Kazutaka, additional, O'Gorman, Peter, additional, Sonneveld, Pieter, additional, Robak, Pawel, additional, Semochkin, Sergey, additional, Schey, Steve, additional, Yu, Xin, additional, Doerr, Thomas, additional, Bensmaine, Amine, additional, Biyukov, Tsvetan, additional, Peluso, Teresa, additional, Zaki, Mohamed, additional, Anderson, Kenneth, additional, Dimopoulos, Meletios, additional, Abildgaard, Niels, additional, Adler, Howard, additional, Altuntas, Fevzi, additional, Akay, Olga Meltem, additional, Amin, Bipinkumar, additional, Anagnostopoulos, Achilleas, additional, Anderson, Larry, additional, Anttila, Pekka, additional, Araujo, Carla, additional, Arce-Lara, Carlos, additional, Aydin, Yildiz, additional, Basu, Supratik, additional, Battini, Ramakrishna, additional, Beeker, Thaddeus, additional, Benboubker, Lotfi, additional, Ben-Yehuda, Dina, additional, Bladé, Joan, additional, Blau, Igor Wolfgang, additional, Boccia, Ralph, additional, Burke, Lillian, additional, Byeff, Peter, additional, Cascavilla, Nicola, additional, Cavo, Michele, additional, Chantry, Andrew, additional, Charles, Yen, additional, Chaudhry, Arvind, additional, Corso, Alessandro, additional, Coyne, Mark, additional, De Arriba, Felipe, additional, Delimpasi, Sosana, additional, Desjardins, Pierre, additional, Dhakal, Binod, additional, Di Bartolomeo, Paolo, additional, Di Raimondo, Francesco, additional, Dürig, Jan, additional, Engelhardt, Monika, additional, Escoffre-Barbe, Martine, additional, Esteves, Graca, additional, Flogegard, Max, additional, Gabrail, Nashat, additional, Gamberi, Barbara, additional, Garrison, Mitchell, additional, Gay, Julie, additional, Gisslinger, Heinz, additional, Goldschmidt, Hartmut, additional, Goncalves, Cristina, additional, Gressot, Laurent, additional, Grosicki, Sebastian, additional, Hanna, Wahid, additional, Hayden, Patrick, additional, Henriques Bernardo, Maria Manuela, additional, Hermann, Robert, additional, Holden, Viran, additional, Honkalehto, Kirsti, additional, Huben, Marianne, additional, Huffman, John, additional, Hunter, Hannah, additional, Hus, Marek, additional, Jagasia, Madan, additional, Jagganath, Sundar, additional, Janakiram, Murali, additional, Jaiyesimi, Ishmael, additional, Jenner, Matthew, additional, João, Cristina, additional, Johnson, Peter, additional, Jurcyszyn, Artur, additional, Kalayoğlu Beşişik, Sevgi, additional, Kambhampati, Suman, additional, Kanate, Abraham, additional, Karadoğan, Ihsan, additional, Khojasteh, Ali, additional, Kirkel, Dean, additional, Komarnicki, Mieczyslaw, additional, Krauth, Maria-Theresa, additional, Kuriakose, Phillip, additional, Larocca, Alessandra, additional, Lauri, Birgitta, additional, Leleu, Xavier, additional, Lucio, Paulo, additional, Luppi, Mario, additional, Mangiacavalli, Silvia, additional, Mariette, Clara, additional, Matsue, Kosei, additional, Mellqvist, Ulf-Henri, additional, Mendeleeva, Larisa, additional, Meshad, Michael, additional, Miller, Carole, additional, Mohrbacher, Ann, additional, Moreau, Philippe, additional, Morelli, Anna Maria, additional, Müldür, Ercan, additional, Naassan, Anthony, additional, Nahi, Hareth, additional, Nair, Rajesh, additional, O'Dwyer, Mike, additional, Öngören Aydin, Seniz, additional, Openshaw, Thomas, additional, O'Rourke, Timothy, additional, Osswald, Michael, additional, Overton, Lindsay, additional, Pati, Asmin, additional, Pavic, Michel, additional, Pegourie, Brigitte, additional, Pehlivan, Mustafa, additional, Pierola, Ana Alfonso, additional, Plesner, Torben, additional, Pluta, Andrzej, additional, Rabin, Neil, additional, Ramasamy, Karthik, additional, Rambaldi, Alessandro, additional, Rodriguez, Paula, additional, Röllig, Christoph, additional, Rosenblatt, Jacalyn, additional, Rosenbluth, Jonathan, additional, Salomo, Morten, additional, Samoylova, Olga, additional, Sastre Moral, Jose, additional, Sati, Hamdi, additional, Selleri, Carmine, additional, Shafeek, Salim, additional, Shinagawa, Atsushi, additional, Sleckman, Bethany, additional, Smith, Clay, additional, Sonmez, Mehmet, additional, Stone, Chester, additional, Streetly, Matthew, additional, Suzuki, Kenshi, additional, Taetle, Raymond, additional, Tafuri, Agostino, additional, Takezako, Naoki, additional, Teke, Hava Üsküdar, additional, Vapaatalo, Mirja, additional, Vassilopoulos, George, additional, Verma, Amit, additional, Vidito, Sarah, additional, Viterbo, Luisa, additional, Vural, Filiz, additional, Wang, Xiang Sean, additional, Yağci, Munci, additional, and Yee, Andrew, additional

Published
2019
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37. Pomalidomide and Dexamethasone for Relapsed/Refractory Multiple Myeloma: A Single-Center Real Life Experience

Author

Cantò, Chiara, primary, Ranucci, Elena, additional, Pulini, Stefano, additional, Santoleri, Fiorenzo, additional, Morelli, Anna Maria, additional, Fioritoni, Francesca, additional, Falorio, Simona, additional, Torti, Lorenza, additional, Spadano, Antonio, additional, D'Aloisio, Marianna, additional, Di Ianni, Mauro, additional, Santarone, Stella, additional, and Di Bartolomeo, Paolo, additional

Published
2018
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38. ANTI-CMV Immunoglobulins in Association with ANTI-CMV Drugs in Patients with Hematological Malignancies Submitted to Allogeneic STEM CELL Transplantation: A MULTI-Center Retrospective Experience

Author

Malagola, Michele, primary, Peccatori, Jacopo, additional, Greco, Raffaella, additional, Serio, Francesca, additional, Santarone, Stella, additional, Iori, Anna Paola, additional, Quatrocchi, Luisa, additional, Barbieri, Walter, additional, Abruzzese, Antonella, additional, Leotta, Salvatore, additional, Carotti, Alessandra, additional, Pierini, Antonio, additional, Rambaldi, Benedetta, additional, Morello, Enrico, additional, Polverelli, Nicola, additional, Turra, Alessandro, additional, Cattina, Federica, additional, Gandolfi, Lisa, additional, Di Bartolomeo, Paolo, additional, Milone, Giuseppe, additional, Velardi, Andrea, additional, Foà, Robin, additional, Ciceri, Fabio, additional, and Russo, Domenico, additional

Published
2018
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39. Donor Lymphocyte Infusions for the Treatment of Relapsed Non-Hodgkin Lymphoma Following Allogeneic Stem Cell Transplantation: A LWP-EBMT Study

Author

Robinson, Stephen, primary, Boumendil, Ariane, additional, Finel, Hervé, additional, Khvedelidze, Irma, additional, Kanfer, Edward, additional, Peggs, Karl, additional, Furst, Sabine, additional, Ram, Ron, additional, Marijt, Waf, additional, Vandenberghe, Elisabeth, additional, Afanasiev, Boris, additional, Wulf, Gerald, additional, Chalandon, Yves, additional, Maertens, Johan, additional, Tsoulkani, Anna, additional, Schaap, Michel, additional, Beelen, Dietrich W., additional, Gurman, Gunhan, additional, Finke, Jürgen, additional, Wittnebel, Sebastian, additional, Di Bartolomeo, Paolo, additional, Tischer, Johanna, additional, Corradini, Paolo, additional, Caballero, Dolores, additional, Marzolini, Maria A V, additional, Burney, Claire, additional, La Nasa, Giorgio, additional, Potter, Victoria, additional, Bittenbring, Jörg Thomas, additional, Fegueux, Nathalie, additional, Kroeger, Nicolaus, additional, Schmitz, Norbert, additional, Dreger, Peter, additional, and Montoto, Silvia, additional

Published
2018
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40. Antithymocyte globulin for graft-versus-host disease prophylaxis in transplants from unrelated donors: 2 randomized studies from Gruppo Italiano Trapianti Midollo Osseo (GITMO)

Author

Bacigalupo, Andrea, Lamparelli, Teresa, Bruzzi, Paolo, Guidi, Stefano, Alessandrino, Paolo Emilio, di Bartolomeo, Paolo, Oneto, Rosa, Bruno, Barbara, Barbanti, Mario, Sacchi, Nicoletta, Van Lint, Maria Teresa, Bosi, Alberto, and for Gruppo Italiano Trapianti Midollo Osseo (GITMO)

Published
2001
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41. Manual of Cardio-oncology Cardiovascular Care in the Cancer Patient

Author

Bidoli, Ettore, Serraino, Diego, Catino, Annamaria, Misino, Andrea, Lagroscino, Antonio, Montagna, Elisabetta Sara, Galetta, Domenico, Tralongo, Paolo, Lestuzzi, Chiara, Furlanello, Francesco, Bisceglia, Irma, Maurea, Nicola, Parrini, Iris, Barni, Sandro, Petrelli, Fausto, Bassani, Barbara, Bruno, Antonino, Macrì, Nicoletta, Corradino, Paola, Noonan, Douglas M., Albini, Adriana, Oliva, Stefano, Monte, Ines, Cardinale, Daniela, Labianca, Roberto, Iliescu, Cezar, Ghiliardi, Laura, Garozzo, Maurizio, Clementi, Anna, Battaglia, Giorgio, Nohria, Anju, Asteggiano, Riccardo, Vellario, Paola, Pessano, Sara, Morsellino, Vera, Haupt, Riccardo, Fratino, Lucia, Beretta, Massimiliano, Derchi, Maria, Stanzione, Brigida, Natale, Annalisa, Santarone, Stella, Di Bartolomeo, Paolo, Bardonaro, Sebastiano, Tralongo, Antonino Carmelo, Pino, Paolo Giuseppe, Roldan, Carlos, Risso, Stefania, Thiene, Gaetano, Valente, Marialuisa, Basso, Cristina, Aquaro, Giovanni Donato, Urbani, Martina, Borsatti, Eugenio, Baresic, Tanja, Santini, Francesco, Viganò, Gaia, Salsano, Antonio, Salvador, Loris, De Paoli, Antonino, Miolo, Gian Maria, Buonadonna, Angela, Santeufemia, Davide, Ferraù, Francesco, Spallarossa, Paolo, Sarocchi, Matteo, Thomas, Olivia Maria, and Caggegi, Maria Agnese

Published
2017

42. Cyclosporin A and short-term methotrexate versus cyclosporin A as graft versus host disease prophylaxis in patients with severe aplastic anemia given allogeneic bone marrow transplantation from an HLA-identical sibling: results of a GITMO/EBMT randomized trial

Author

Locatelli, Franco, Bruno, Barbara, Zecca, Marco, Van-Lint, Maria Teresa, McCann, Shaun, Arcese, William, Dallorso, Sandro, Di Bartolomeo, Paolo, Fagioli, Franca, Locasciulli, Anna, Lawler, Mark, and Bacigalupo, Andrea

Published
2000
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43. Autologous hematopoietic stem cell transplantation in multiple sclerosis: A phase II trial

Author

Mancardi, Giovanni L., Sormani, Maria P., Gualandi, Francesca, Saiz, Albert, Carreras, Eric, Merelli, Elisa, Donelli, Amedea, Di Bartolomeo, Paolo, Rottoli, Maria R., Rambaldi, Alessandro, Amato, Maria P., Massacesi, Luca, Di Gioia, Massimo, Vuolo, Luisa, Currò, Daniela, Roccatagliata, Luca, Filippi, Massimo, Aguglia, Umberto, Iacopino, Pasquale, Farge, Dominique, Saccardi, Riccardo, ASTIMS Haemato Neurological Collaborative Group, on behalf of the Autoimmune Disease Working Party of the European Group for Blood, Marrow Transplantation, ASTIMS Haemato Neurological Collaborative Group on behalf of the Autoimmune Disease Working Party ADWP of the European Group for Blood, Marrow Transplantation EBMT, LUGARESI, ALESSANDRA, Mancardi, Gl, Sormani, Mp, Gualandi, F, Saiz, A, Carreras, E, Merelli, E, Donelli, A, Lugaresi, A, Di Bartolomeo, P, Rottoli, Mr, Rambaldi, A, Amato, Mp, Massacesi, L, Di Gioia, M, Vuolo, L, Currà, D, Roccatagliata, L, Filippi, Massimo, Aguglia, U, Iacopino, P, Farge, D, Saccardi, R., Mancardi, Giovanni L., Sormani, Maria P., Gualandi, Francesca, Saiz, Albert, Carreras, Eric, Merelli, Elisa, Donelli, Amedea, Lugaresi, Alessandra, Di Bartolomeo, Paolo, Rottoli, Maria R., Rambaldi, Alessandro, Amato, Maria P., Massacesi, Luca, Di Gioia, Massimo, Vuolo, Luisa, Currò, Daniela, Roccatagliata, Luca, Aguglia, Umberto, Iacopino, Pasquale, Farge, Dominique, Saccardi, Riccardo, ASTIMS Haemato-Neurological Collaborative Group, on behalf of the Autoimmune Disease Working Party (ADWP) of the European Group for Blood and Marrow Transplantation (EBMT)., and ASTIMS Haemato-Neurological Collaborative Group on behalf of the Autoimmune Disease Working Party ADWP of the European Group for Blood and Marrow Transplantation EBMT

Subjects
Oncology, Adult, Male, medicine.medical_specialty, Transplantation Conditioning, medicine.medical_treatment, Antineoplastic Agents, Gadolinium, Hematopoietic stem cell transplantation, Filgrastim, Transplantation, Autologous, Antineoplastic Agent, Young Adult, Multiple Sclerosis, Relapsing-Remitting, Internal medicine, medicine, Clinical endpoint, Humans, Carmustine, Mitoxantrone, Expanded Disability Status Scale, business.industry, Hematopoietic Stem Cell Transplantation, Immunosuppression, Middle Aged, Multiple Sclerosis, Chronic Progressive, Image Enhancement, Magnetic Resonance Imaging, Transplantation, Autologou, Transplantation, Treatment Outcome, Immunology, Female, Neurology (clinical), business, Human, medicine.drug
Abstract

Objective: To assess in multiple sclerosis (MS) the effect of intense immunosuppression followed by autologous hematopoietic stem cells transplantation (AHSCT) vs mitoxantrone (MTX) on disease activity measured by MRI. Methods: We conducted a multicenter, phase II, randomized trial including patients with secondary progressive or relapsing-remitting MS, with a documented increase in the last year on the Expanded Disability Status Scale, in spite of conventional therapy, and presence of one or more gadolinium-enhancing (Gd+) areas. Patients were randomized to receive intense immunosuppression (mobilization with cyclophosphamide and filgrastim, conditioning with carmustine, cytosine-arabinoside, etoposide, melphalan, and anti-thymocyte globulin) followed by AHSCT or MTX 20 mg every month for 6 months. The primary endpoint was the cumulative number of new T2 lesions in the 4 years following randomization. Secondary endpoints were the cumulative number of Gd+ lesions, relapse rate, and disability progression. Safety and tolerability were also assessed. Twenty-one patients were randomized and 17 had postbaseline evaluable MRI scans. Results: AHSCT reduced by 79% the number of new T2 lesions as compared to MTX (rate ratio 0.21, p = 0.00016). It also reduced Gd+ lesions as well as the annualized relapse rate. No difference was found in the progression of disability. Conclusion: Intense immunosuppression followed by AHSCT is significantly superior to MTX in reducing MRI activity in severe cases of MS. These results strongly support further phase III studies with primary clinical endpoints. The study was registered as EUDRACT No. 2007-000064-24.

Published
2015

44. NOTCH and Graft-Versus-Host Disease

Author

Di Ianni, Mauro, primary, Del Papa, Beatrice, additional, Baldoni, Stefano, additional, Di Tommaso, Ambra, additional, Fabi, Bianca, additional, Rosati, Emanuela, additional, Natale, Annalisa, additional, Santarone, Stella, additional, Olioso, Paola, additional, Papalinetti, Gabriele, additional, Giancola, Raffaella, additional, Accorsi, Patrizia, additional, Di Bartolomeo, Paolo, additional, Sportoletti, Paolo, additional, and Falzetti, Franca, additional

Published
2018
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45. NOTCH1 Is Aberrantly Activated in Chronic Lymphocytic Leukemia Hematopoietic Stem Cells

Author

Di Ianni, Mauro, primary, Baldoni, Stefano, additional, Del Papa, Beatrice, additional, Aureli, Patrizia, additional, Dorillo, Erica, additional, De Falco, Filomena, additional, Albi, Elisa, additional, Varasano, Emanuela, additional, Di Tommaso, Ambra, additional, Giancola, Raffaella, additional, Accorsi, Patrizia, additional, Rotta, Gianluca, additional, Rompietti, Chiara, additional, Silva Barcelos, Estevão Carlos, additional, Campese, Antonio Francesco, additional, Di Bartolomeo, Paolo, additional, Screpanti, Isabella, additional, Rosati, Emanuela, additional, Falzetti, Franca, additional, and Sportoletti, Paolo, additional

Published
2018
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46. First Report of the Gimema LAL1811 Phase II Prospective Study of the Combination of Steroids with Ponatinib As Frontline Therapy of Elderly or Unfit Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Author

Martinelli, Giovanni, primary, Piciocchi, Alfonso, additional, Papayannidis, Cristina, additional, Paolini, Stefania, additional, Robustelli, Valentina, additional, Soverini, Simona, additional, Terragna, Carolina, additional, Lemoli, Roberto M, additional, Guolo, Fabio, additional, Di Bartolomeo, Paolo, additional, Lunghi, Monia, additional, de Fabritiis, Paolo, additional, Candoni, Anna, additional, Selleri, Carmine, additional, Simonetti, Federico, additional, Bocchia, Monica, additional, Vitale, Antonella, additional, Frison, Luca, additional, Tedeschi, Alessandra, additional, Cuneo, Antonio, additional, Bonifacio, Massimiliano, additional, Falini, Brunangelo, additional, D'Ardia, Stefano, additional, Trappolini, Silvia, additional, Tosi, Patrizia, additional, Galieni, Piero, additional, Fabbiano, Francesco, additional, Abbenante, Maria Chiara, additional, Marconi, Giovanni, additional, Sartor, Chiara, additional, Cavo, Michele, additional, Foà, Robin, additional, Fazi, Paola, additional, Vignetti, Marco, additional, and Baccarani, Michele, additional

Published
2017
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49. Health Related Quality of Life of Long-Term Survivors of Acute Promyelocytic Leukemia Treated with All-Trans Retinoic Acid and Chemotherapy

Author

Efficace, Fabio, primary, Mandelli, Franco, additional, Borlenghi, Erika, additional, Breccia, Massimo, additional, Rambaldi, Alessandro, additional, Specchia, Giorgina, additional, Rodeghiero, Francesco, additional, Morselli, Monica, additional, Fabbiano, Francesco, additional, Cantore, Nicola, additional, Angelucci, Emanuele, additional, Caramatti, Cecilia, additional, Di Bartolomeo, Paolo, additional, Pizzolo, Giovanni, additional, Vignetti, Marco, additional, and Lo Coco, Francesco, additional

Published
2016
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50. Comparison of Haematopoietic Stem Cell Transplantation Approaches in Primary Plasma Cell Leukaemia

Author

Lawless, Sarah, primary, Simona, Iacobelli, additional, van Biezen, Anja, additional, Koster, Linda, additional, Chevallier, Patrice, additional, Blaise, Didier, additional, Foà, Roberto, additional, Tabrizi, Reza, additional, Schaap, Nicolaas PM, additional, Lenhoff, Stig, additional, Russell, Nigel H., additional, Poiré, Xavier, additional, Petersen, Eefke, additional, Cornelissen, Jan J., additional, Di Bartolomeo, Paolo, additional, Wilson, Keith, additional, Schipperus, Martin, additional, Lioure, Bruno, additional, Arcese, William, additional, Mufti, Ghulam J, additional, Snowden, John A, additional, Finke, Jurgen, additional, Morris, Curly, additional, Garderet, Laurent, additional, Kröger, Nicolaus, additional, and Schönland, Stefan, additional

Published
2016
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