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The ab initio molecular dynamics simulations were adopted to study the atomic structures of Co92−xBxTa8 (x = 30, 32.5, 35, 37.5, at%) glassy alloys. The results showed that the local packing of B‐centered clusters was more efficient than that of Co‐ and Ta‐centered clusters. It was also found that B‐centered clusters were the primary structure‐forming clusters. The Kasper polyhedra with a Voronoi index of <0 3 6 0> and <0 2 8 0> are dominant in B‐centered clusters. The <0 3 6 0> clusters could especially be formed into a robust network structure, which plays a key role in the increase of mechanical properties. Such a network structure has a higher activation barrier for structural rearrangement and a larger resistance to plastic flow. Thus, the increase in the fraction of <0 3 6 0> with B content would result in an increase in yield strength, as well as a sharp decrease in compressive plasticity. [ABSTRACT FROM AUTHOR]

Introduction: The influenza virus is recognized as the primary cause of human respiratory diseases, with the current influenza vaccine primarily offering strain-specific immunity and limited protection against drifting strains. Considering this, the development of a broad-spectrum influenza vaccine capable of inducing effective immunity is considered the future direction in combating influenza., Methods: The present study proposes a novel mRNA-based multi-epitope influenza vaccine, which combines three conserved antigens derived from the influenza A virus. The antigens consist of M2 ion channel's extracellular domain (M2e), the conserved epitope of located in HA2 of hemagglutinin (H1, H3, B), and HA1 of hemagglutinin. At the same time, trimeric sequences and ferritin were conjugated separately to investigate the immune effects of antigen multivalent presentation., Results: Immunization studies conducted on C57BL/6 mice with these vaccines revealed that they can elicit both humoral immunity and CD4 + and CD8 + T cell responses, which collectively contribute to enhancing cross-protective effects. The virus challenge results showed that vaccinated groups had significantly reduced lung damage, lower viral loads in the lungs, nasal turbinates, and trachea, as well as decreased levels of pro-inflammatory cytokines., Conclusion: These findings clearly demonstrate the wide range of protective effects provided by these vaccines against H1N1 and B influenza viruses. The present finding highlights the potential of mRNA-based influenza vaccines encoding conserved proteins as a promising strategy for eliciting broad-spectrum protective humoral and cellular immunity against H1N1 and B influenza viruses., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Di, Zhang, Ren, Jiang, Tang, Yang, Wang, Yu, Zhang, Yu, Xu, Zhuang, Jin and Tian.)