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23. Circulating Tumor Cells in Esophageal Squamous Cell Carcinoma – Mini Review

Author

Shi,Yujing, Ge,Xiaolin, Ju,Mengyang, Zhang,Yumeng, Di,Xiaoke, and Liang,Liang

Subjects
Cancer Management and Research
Abstract

Yujing Shi,1 Xiaolin Ge,2 Mengyang Ju,3 Yumeng Zhang,4 Xiaoke Di,2 Liang Liang1 1Jurong People’s Hospital, Zhenjiang, 212400, People’s Republic of China; 2Jiangsu Provincial People’s Hospital, Nanjing, 212000, People’s Republic of China; 3Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, 5650871, Japan; 4Nanjing Medical University, Nanjing, 212000, People’s Republic of ChinaCorrespondence: Liang LiangJurong People’s Hospital, Huayang Town, Jurong City, People’s Republic of ChinaTel +86 511-8730 0705Email lianglvlv@yeah.netAbstract: Esophageal cancer has high incidence and mortality rates and a low five-year survival rate of < 15% owing to its strong capabilities of invasion, relapse and metastasis. The classic view holds that metastasis and diffusion is an advanced event during cancer progression, but recent studies show that distant diffusion of primary cancer cells may actually be an early event. Detection of circulating tumor cells (CTCs) in the circulation may indicate tumor spread, so CTCs are considered to be the key factor of metastatic cascade. In recent years, despite research progress on CTCs, there is a lack of systematic and important evidence to confirm the diagnostic, monitoring and prognostic values of CTCs in esophageal squamous cell carcinoma (ESCC). In this review, we clarify the relationship between CTC values and ESCC and provide more reliable evidence to improve the management and treatment of ESCC.Keywords: esophageal squamous cell carcinoma, circulating tumor cells, diagnostic, prognostic

Published
2021

30. High‐mobility group box 1 protein modulated proliferation and radioresistance in esophageal squamous cell carcinoma.

Author

Di, Xiaoke, He, Guofeng, Chen, Hui, Zhu, Caiqiang, Qin, Qin, Yan, Jingjing, Zhang, Xiaowen, and Sun, Xinchen

Subjects
*ESOPHAGEAL cancer, *SQUAMOUS cell carcinoma, *FORKHEAD transcription factors, *DNA damage, *DNA repair, *CELL death
Abstract

Background and Aim: The high‐mobility group box 1 (HMGB1) protein plays an important role in a lot of biological behaviors, including DNA damage repair, gene transcription, cell replication, and cell death, and its expression is higher in many solid tumors tissues than in their adjacent normal tissues, and it is always involved in tumor proliferation, metastasis, therapeutic tolerance, and poor prognosis. However, HMGB1 in proliferation and radioresistance of esophageal squamous cell carcinoma (ESCC) remains poorly understood. In this study, the effect of HMGB1 on proliferation, cell death, DNA damage repair and radioresistance, and its underlying mechanism was investigated in human ESCC. Methods: The immunohistochemistry scores of tumor and adjacent normal tissues in ESCC tissue microarray were analyzed. Stable HMGB1 knockdown cell lines were constructed using Kyse150 and Kyse450 cells. Cell viability, radioresistance, apoptosis, autophagy, and DNA damage were determined using CCK‐8, 5‐ethynyl‐2′‐deoxyuridine, clonogenic survival assay, immunofluorescence, flow cytometry, and western blot assays. Results: Differential analyses showed that the expression of HMGB1 in esophageal cancer tissue was significantly higher than that in adjacent normal tissues. The downregulation of HMGB1 could effectively inhibit proliferation, increase radiosensitivity, impair DNA damage repair abilities, reduce autophagy, and increase apoptosis rates in ESCC cells after irradiation. Conclusions: HMGB1 is expected to be a potential target for ESCC therapy and radiosensitization. [ABSTRACT FROM AUTHOR]

Published
2019
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