Search

Your search keyword '"Dhawan, Vijay"' showing total 571 results
Start Over Author "Dhawan, Vijay"
571 results on '"Dhawan, Vijay"'

4. Longitudinal Network Changes and Phenoconversion Risk in Isolated REM Sleep Behavior Disorder

Author

Eidelberg, David, primary, Tang, Chris, additional, Nakano, Yoshikazu, additional, Vo, An, additional, Nguyen, Nha, additional, Schindlbeck, Katharina, additional, Poston, Kathleen, additional, Gagnon, Jean-François, additional, Postuma, Ronald, additional, Niethammer, Martin, additional, Ma, Yilong, additional, Peng, Shichun, additional, and Dhawan, Vijay, additional

Published
2024
Full Text
View/download PDF

5. Deep brain stimulation of the subthalamic nucleus for Parkinson’s disease: A network imaging marker of the treatment response

Author

Eidelberg, David, primary, Unadkat, Prashin, additional, Dhawan, Vijay, additional, Tang, Chris, additional, Ma, Yilong, additional, Peng, Shichun, additional, Vo, An, additional, Nguyen, Nha, additional, Niethammer, Martin, additional, Caminiti, Silvia Paola, additional, Perani, Daniela, additional, Ramdhani, Ritesh, additional, and Fenoy, Albert, additional

Published
2024
Full Text
View/download PDF

24. Network modulation following sham surgery in Parkinson's disease

Author

Ko, Ji Hyun, Feigin, Andrew, Mattis, Paul J., Tang, Chris C., Ma, Yilong, Dhawan, Vijay, During, Matthew J., Kaplitt, Michael G., and Eidelberg, David

Subjects
Gene therapy -- Health aspects -- Research, Parkinson's disease -- Diagnosis -- Care and treatment -- Research, Surgery -- Health aspects -- Research, Health care industry
Abstract

Patient responses to placebo and sham effects are a major obstacle to the development of therapies for brain disorders, including Parkinson's disease (PD). Here, we used functional brain imaging and network analysis to study the circuitry underlying placebo effects in PD subjects randomized to sham surgery as part of a double-blind gene therapy trial. Metabolic imaging was performed prior to randomization, then again at 6 and 12 months after sham surgery. In this cohort, the sham response was associated with the expression of a distinct cerebello-limbic circuit. The expression of this network increased consistently in patients blinded to treatment and correlated with independent clinical ratings. Once patients were unblinded, network expression declined toward baseline levels. Analogous network alterations were not seen with open-label levodopa treatment or during disease progression. Furthermore, sham outcomes in blinded patients correlated with baseline network expression, suggesting the potential use of this quantitative measure to identify 'sham-susceptible' subjects before randomization. Indeed, Monte Carlo simulations revealed that a priori exclusion of such individuals substantially lowers the number of randomized participants needed to demonstrate treatment efficacy. Individualized subject selection based on a predetermined network criterion may therefore limit the need for sham interventions in future clinical trials., Introduction Placebo effects pose a major challenge in the development of new treatments for neurodegenerative disorders. Parkinson's disease (PD) is a case in point. Prominent placebo (or shamsurgical) responses are [...]

Published
2014
Full Text
View/download PDF

29. Metabolic network as a progression biomarker of premanifest Huntington's disease

Author

Tang, Chris C., Feigin, Andrew, Ma, Yilong, Habeck, Christian, Paulsen, Jane S., Leenders, Klaus L., Teune, Laura K., Oostrom, Joost C.H. van, Guttman, Mark, Dhawan, Vijay, and Eidelberg, David

Subjects
Huntington's chorea -- Development and progression -- Research, Cell metabolism -- Research, Biological markers -- Research, Health care industry
Abstract

Background. The evaluation of effective disease-modifying therapies for neurodegenerative disorders relies on objective and accurate measures of progression in at-risk individuals. Here we used a computational approach to identify a functional brain network associated with the progression of preclinical Huntington's disease (HD). Methods. Twelve premanifest HD mutation carriers were scanned with [[.sup.18]F]-fluorodeoxyglucose PET to measure cerebral metabolic activity at baseline and again at 1.5, 4, and 7 years. At each time point, the subjects were also scanned with [[.sup.11]C]-raclopride PET and structural MRI to measure concurrent declines in caudate/putamen [D.sub.2] neuroreceptor binding and tissue volume. The rate of metabolic network progression in this cohort was compared with the corresponding estimate obtained in a separate group of 21 premanifest HD carriers who were scanned twice over a 2-year period. Results. In the original premanifest cohort, network analysis disclosed a significant spatial covariance pattern characterized by progressive changes in striatothalamic and cortical metabolic activity. In these subjects, network activity increased linearly over 7 years and was not influenced by intercurrent phenoconversion. The rate of network progression was nearly identical when measured in the validation sample. Network activity progressed at approximately twice the rate of single region measurements from the same subjects. Conclusion. Metabolic network measurements provide a sensitive means of quantitatively evaluating disease progression in premanifest individuals. This approach may be incorporated into clinical trials to assess disease-modifying agents. Trial registration. Registration is not required for observational studies. Funding. NIH (National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering) and CHDI Foundation Inc., Introduction The identification of objective and accurate biomarkers of disease progression will help expedite the evaluation of effective disease-modifying therapies for neurodegenerative disorders. Brain imaging provides one such opportunity through [...]

Published
2013
Full Text
View/download PDF

44. Contributors

Author

Aguzzi, Adriano, primary, Albers, James W., additional, Alger, Jeffry R., additional, Allen, Richard P., additional, Aranow, Cynthia, additional, Backonja, Misha-Miroslav, additional, Balmer, Curtis W., additional, Batchelor, Tracy, additional, Benarroch, Eduardo E., additional, Berciano, José, additional, Bertram, Edward H., additional, Bhatia, Radhika, additional, Biller, Jose, additional, Birbeck, Gretchen L., additional, Bleck, Thomas P., additional, Bosworth, Brian P., additional, Bowsher, David, additional, Brooks, Benjamin, additional, Bukelis, Irena, additional, Caronna, John J., additional, Carter, John C., additional, Cavaletti, Guido, additional, Chand, Pratap, additional, Chong, Ji Y., additional, Cleland, James C., additional, Colosimo, Carlo, additional, Condon, Timothy P., additional, Sander Connolly, E., additional, Cortopassi, Gino, additional, Crystal, Ronald G., additional, Cutting, Laurie E., additional, Dafer, Rima M., additional, Dalakas, Marinos C., additional, Dalmau, Josep, additional, de Saint Martin, Anne, additional, Detre, John A., additional, Dhawan, Vijay, additional, Diamond, Betty, additional, Patrick Andrews Drummond, Sean, additional, Eidelberg, David, additional, Eisenach, John H., additional, Elshihabi, Said, additional, Fan, QiWen, additional, Fealey, Robert D., additional, Ferrari, Michel D., additional, Ferriero, Donna M., additional, Fink, Gereon R., additional, Fischbeck, Kenneth H., additional, Furie, Karen, additional, Gálvez-Jiménez, Néstor, additional, Geser, Felix, additional, Glatzel, Markus, additional, Goadsby, Peter J., additional, Goldin, Alan L., additional, Greenland, Karen J., additional, Griggs, Robert C., additional, Gutmann, David H., additional, Hagel, Christian, additional, Hagerman, Paul J., additional, Harris, Kendra, additional, Hartung, Hans-Peter, additional, Hemmer, Bernhard, additional, Heppner, Frank L., additional, Herbert, Martha R., additional, Herrmann, David N., additional, Hirano, Michio, additional, Hirsch, Edouard, additional, Hoff, Julian T., additional, Hoon, Alexander H., additional, Hyman, Bradley T., additional, Jain, Samay, additional, Jänig, Wilfrid, additional, Jaradeh, Safwan S., additional, Jellinger, Kurt A., additional, Joyner, Michael J., additional, Kaufmann, Walter E., additional, Keep, Richard F., additional, Kellogg, Aaron, additional, Kieseier, Bernd C., additional, Kinsman, Stephen L., additional, Köller, Hubertus, additional, Kowal, Czeslawa, additional, Lamszus, Katrin, additional, Landzberg, Brian R., additional, Lev, Michael H., additional, Lieberman, David N., additional, Lim, Leland E., additional, Lipkin, Paul H., additional, Litvan, Irene, additional, London, Zachary, additional, Low, Phillip A., additional, Mackay, Meggan, additional, Mahowald, Mark W., additional, Manzo, Luigi, additional, Maragakis, Nicholas J., additional, Masdeu, Joseph C., additional, Mazzoni, Pietro, additional, McLean, Pamela J., additional, Mercadante, Sebastiano, additional, Meyer, Ana-Claire, additional, Mignot, Emmanuel, additional, Miller, Steven P., additional, Mostofsky, Stewart, additional, Mrugala, Maciej, additional, Newcomer, Anne, additional, Nobbio, Lucilla, additional, Noorbakhsh, Farshid, additional, Novak, Peter, additional, O'Donoghue, John L., additional, Orr, Harry T., additional, Fleming Outiero, Tiago, additional, Palestrant, David, additional, Pedley, Timothy A., additional, Perez-Velasquez, Jose-Luis, additional, Perlis, Michael L., additional, Persson, Anders I., additional, Phillips, Joanna J., additional, Piersall, Linda, additional, Pigeon, Wilfred R., additional, Pomerantz, Stuart R., additional, Pop-Busui, Rodica, additional, Power, Christopher, additional, Powers, James M., additional, Rando, Thomas A., additional, Ratan, Rajiv R., additional, Rimrodt, Sheryl L., additional, Rothstein, Jeffrey D., additional, Russell, James W., additional, Rutka, James T., additional, Saling, Michael M., additional, Scharfman, Helen E., additional, Schenck, Carlos H., additional, Schenone, Angelo, additional, Schrage, William G., additional, Schroeter, Michael, additional, Schütz, Peter W., additional, Simmons, Zachary, additional, Singer, Harvey S., additional, Singh, Ajay K., additional, Singleton, J.R., additional, Smith, A.G., additional, Carter Snead, O., additional, Sorenson, Eric J., additional, Srikanth, Velandai, additional, Stöckler, Sylvia, additional, Sumner, Charlotte J., additional, Swash, Michael, additional, Teener, James W., additional, Thornton, Charles A., additional, Thrift, Amanda G., additional, Töpfnerz, Nicole, additional, Tsuji, Shoji, additional, Turetz, Meredith L., additional, Twydell, Paul, additional, Vercueil, Laurent, additional, Vernino, Steven, additional, Vincent, Angela, additional, Volpe, Bruce T., additional, Wagner, Kenneth R., additional, Walkley, Steven U., additional, Weil, Robert J., additional, Weiss, William A., additional, Weksler, Babette B., additional, Wenning, Gregor K., additional, Westner, Ingo M., additional, Westphal, Manfred, additional, Wilkinson, Philip A., additional, Wong, Alice, additional, Xi, Guohua, additional, Zajac, Jeffrey D., additional, and Zeitzer, Jamie M., additional

Published
2007
Full Text
View/download PDF

49. PET/SPECT

Author

Trošt, Maja, primary, Dhawan, Vijay, additional, Feigin, Andrew, additional, and Eidelberg, David, additional

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results