371 results on '"Dhatariya, K"'
Search Results
2. O007 Glycaemic variability is a predictor of graft failure following infra-inguinal bypass for peripheral arterial disease (PAD). A retrospective cohort study
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Farndon, D, primary, Bennett, P, additional, Nunney, I, additional, and Dhatariya, K, additional
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- 2023
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3. 5 year retrospective follow-up of new cases of Charcot neuroarthropathy—A single centre experience
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Stark, C., Murray, T., Gooday, C., Nunney, I., Hutchinson, R., Loveday, D., and Dhatariya, K.
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- 2016
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4. Factors determining the risk of diabetes foot amputations – A retrospective analysis of a tertiary diabetes foot care service
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Beaney, A.J., Nunney, I., Gooday, C., and Dhatariya, K.
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- 2016
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5. Complications Post Endovascular Abdominal Aortic Aneurysm Repair in Patients with Diabetes Mellitus: A Meta-analysis and Systematic Review
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Otify, EA, primary, Mekki, M, additional, Borucki, J, additional, Dhatariya, K, additional, and Stather, P W, additional
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- 2023
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6. Analysis of attitudes towards and experiences with physician associates in diabetes and endocrinology: a survey of Association of British Clinical Diabetologists members.
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Hussain, S., Hope, O. H. B., Dhatariya, K., Fayers, K., Jayagopal, V., and Price, H. C.
- Published
- 2024
7. Optimal staffing for a good quality inpatient diabetes service.
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Dashora, U., Flanagan, D., Rayman, G., Mustafa, O. G., Walden, E., and Dhatariya, K.
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TREATMENT of diabetes ,MEDICAL quality control ,MEETINGS ,CONSENSUS (Social sciences) ,HOSPITAL patients ,ATTITUDES of medical personnel ,CONVERSATION ,MEDICAL care ,MEDICAL consultants ,PSYCHOLOGISTS ,MEDICAL personnel ,HOSPITAL care ,HEALTH care teams ,EXPERTISE ,QUESTIONNAIRES ,DESCRIPTIVE statistics ,WORKING hours ,NURSE practitioners ,NUTRITIONISTS - Abstract
Introduction: Increasing numbers of people admitted to hospital have diabetes and need specialist support. To date, there is no mechanism which can help teams estimate the number of health care professionals they need to provide optimal care for people with diabetes in hospitals. Methods: The Joint British Diabetes Societies (JBDS) for Inpatient Care Group organised a survey of specialist inpatient diabetes teams in the UK for current staffing and the perception of optimal staffing using mailing lists available through their representative organisations. The results were verified and confirmed by one‐to‐one conversations with individual respondents and discussed in multiple expert‐group meetings to agree on the results. Results: Responses were received from 17 Trusts covering 30 hospital sites. Current diabetes specialist staffing level per 100 people with diabetes in hospital (Median, IQR) for consultants was 0.24 (0.22–0.37), diabetes inpatient specialist nurses was 1.94 (1.22–2.6), dieticians was 0.00 (0.00–0.00), podiatrists was 0.19 (0.00–0.62), pharmacists was 0.00 (0.00–0.37), psychologists was 0.00 (0.00–0.00). The teams also reported that for optimal care the total staff needed for each group (Median, IQR) was much higher; consultants 0.65 (0.50–0.88), specialist nurses 3.38 (2.78–4.59), dieticians 0.48 (0.33–0.72), podiatrists, 0.93 (0.65–1.24), pharmacists, 0.65 (0.40–0.79) and psychologists 0.33 (0.27–0.58). Based on the results of the survey, the JBDS expert group produced an Excel calculator to estimate staffing needs of any hospital site in question just by populating a few of the cells. Conclusion: Current inpatient diabetes staffing is much lower than needed in most Trusts who responded to the survey. The JBDS calculator can provide an estimate of the staffing needs of any hospital. [ABSTRACT FROM AUTHOR]
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- 2023
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8. The cost of treating diabetic ketoacidosis in the UK: a national survey of hospital resource use
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Dhatariya, K. K., Skedgel, C., and Fordham, R.
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- 2017
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9. New horizons in the understanding of the causes and management of diabetic foot disease: report from the 2017 Diabetes UK Annual Professional Conference Symposium
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Clokie, M., Greenway, A. L., Harding, K., Jones, N. J., Vedhara, K., Game, F., and Dhatariya, K. K.
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- 2017
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10. Use of haemoglobin A1c to detect impaired fasting glucose or Type 2 diabetes in a United Kingdom community based population
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Kumaravel, B., Bachmann, M.O., Murray, N., Dhatariya, K., Fenech, M., John, W.G., Scarpello, T.J., and Sampson, M.J.
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- 2012
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11. Clinical guidelines for type 1 diabetes mellitus with an emphasis on older adults: an Executive Summary
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Sinclair, A. J., Dunning, T., Dhatariya, K., Sheu, Wayne H. ‐H., Lin, Shih‐Yi, Hafiz, Ahmed, Meneilly, Graydon, Munshi, Medha, Paolisso, Giuseppe, Marfella, Raffaele, Rodriguez Manas, Leocadio, Sinay, Isaac, Rosas, Sylvia, Bellary, Srikanth, Prasad, Noela M., Le Mesurier, Richard, Tesfaye, Solomon, Robins, Michelle, Sampson, Michael, Sinclair, A. J., Dunning, T., Dhatariya, K., Sheu, Wayne H. ‐H., Lin, Shih‐yi, Hafiz, Ahmed, Meneilly, Graydon, Munshi, Medha, Paolisso, Giuseppe, Marfella, Raffaele, Rodriguez Manas, Leocadio, Sinay, Isaac, Rosas, Sylvia, Bellary, Srikanth, Prasad, Noela M., Le Mesurier, Richard, Tesfaye, Solomon, Robins, Michelle, and Sampson, Michael
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Male ,Gerontology ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Special needs ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Diabetes management ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Medical nutrition therapy ,Aged ,Aged, 80 and over ,Type 1 diabetes ,Executive summary ,business.industry ,Ketosis ,Guideline ,medicine.disease ,Hypoglycemia ,Ketoacidosis ,Diabetes Mellitus, Type 1 ,Practice Guidelines as Topic ,Female ,business - Abstract
We present a summary of a guideline produced by an international group of experts for managing type 1 diabetes in adults with an emphasis on the special needs of older people with this condition. The rationale for delivering high-quality diabetes care for adults with type 1 diabetes, why it is important to include older people in our considerations, and the key underpinning principles of the guideline are included. The structure of the recommendations given is described and consists of 'general' recommendations followed by 'specific' recommendations according to three categories depending on the characteristics of adults addressed, such as functional level or self-management ability. Recommendations are provided in the areas of: clinical diagnosis, establishing management plans and glucose regulation, diabetes self-management education, nutritional therapy, physical activity, exercise and lifestyle modification, insulin treatments and regimens, use of technology in diabetes management, hypoglycaemia, managing cardiovascular risk, management of microvascular risk, and inpatient management of type 1 diabetes and ketoacidosis.
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- 2019
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12. Screening for diabetes peri‐operatively: a reply
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Lam, S., primary, Kumar, B., additional, and Dhatariya, K., additional
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- 2022
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13. Reply to Rowe et al Re: Managing hyperglycaemia during antenatal steroid administration, labour and birth in pregnant women with diabetes –an updated guideline from the Joint British Diabetes Society for Inpatient Care Dashora et al. Diabetic Medicine. 2022;39:e14744
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Dashora, Umesh, primary, Levy, Nicholas, additional, Dhatariya, K, additional, Willer, Nina, additional, Castro, E, additional, and Murphy, HR, additional
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- 2022
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14. Glycated haemoglobin and the risk of postoperative complications in people without diabetes: a prospective population‐based study in UK Biobank
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Lam, S., primary, Kumar, B., additional, Loke, Y. K., additional, Orme, S. E., additional, and Dhatariya, K., additional
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- 2022
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15. National survey of the management of Diabetic Ketoacidosis (DKA) in the UK in 2014
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Dhatariya, K. K., Nunney, I., Higgins, K., Sampson, M. J., and Iceton, G.
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- 2016
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16. Institutional factors in the management of adults with diabetic ketoacidosis in the UK: results of a national survey
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Dhatariya, K., Nunney, I., and Iceton, G.
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- 2016
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17. Perioperative nutrition: Recommendations from the ESPEN expert group
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Lobo, D, Gianotti, L, Adiamah, A, Barazzoni, R, Deutz, N, Dhatariya, K, Greenhaff, P, Hiesmayr, M, Hjort Jakobsen, D, Klek, S, Krznaric, Z, Ljungqvist, O, Mcmillan, D, Rollins, K, Panisic Sekeljic, M, Skipworth, R, Stanga, Z, Stockley, A, Stockley, R, Weimann, A, Lobo D. N., Gianotti L., Adiamah A., Barazzoni R., Deutz N. E. P., Dhatariya K., Greenhaff P. L., Hiesmayr M., Hjort Jakobsen D., Klek S., Krznaric Z., Ljungqvist O., McMillan D. C., Rollins K. E., Panisic Sekeljic M., Skipworth R. J. E., Stanga Z., Stockley A., Stockley R., Weimann A., Lobo, D, Gianotti, L, Adiamah, A, Barazzoni, R, Deutz, N, Dhatariya, K, Greenhaff, P, Hiesmayr, M, Hjort Jakobsen, D, Klek, S, Krznaric, Z, Ljungqvist, O, Mcmillan, D, Rollins, K, Panisic Sekeljic, M, Skipworth, R, Stanga, Z, Stockley, A, Stockley, R, Weimann, A, Lobo D. N., Gianotti L., Adiamah A., Barazzoni R., Deutz N. E. P., Dhatariya K., Greenhaff P. L., Hiesmayr M., Hjort Jakobsen D., Klek S., Krznaric Z., Ljungqvist O., McMillan D. C., Rollins K. E., Panisic Sekeljic M., Skipworth R. J. E., Stanga Z., Stockley A., Stockley R., and Weimann A.
- Abstract
Background & aims: Malnutrition has been recognized as a major risk factor for adverse postoperative outcomes. The ESPEN Symposium on perioperative nutrition was held in Nottingham, UK, on 14–15 October 2018 and the aims of this document were to highlight the scientific basis for the nutritional and metabolic management of surgical patients. Methods: This paper represents the opinion of experts in this multidisciplinary field and those of a patient and caregiver, based on current evidence. It highlights the current state of the art. Results: Surgical patients may present with varying degrees of malnutrition, sarcopenia, cachexia, obesity and myosteatosis. Preoperative optimization can help improve outcomes. Perioperative fluid therapy should aim at keeping the patient in as near zero fluid and electrolyte balance as possible. Similarly, glycemic control is especially important in those patients with poorly controlled diabetes, with a stepwise increase in the risk of infectious complications and mortality per increasing HbA1c. Immobilization can induce a decline in basal energy expenditure, reduced insulin sensitivity, anabolic resistance to protein nutrition and muscle strength, all of which impair clinical outcomes. There is a role for pharmaconutrition, pre-, pro- and syn-biotics, with the evidence being stronger in those undergoing surgery for gastrointestinal cancer. Conclusions: Nutritional assessment of the surgical patient together with the appropriate interventions to restore the energy deficit, avoid weight loss, preserve the gut microbiome and improve functional performance are all necessary components of the nutritional, metabolic and functional conditioning of the surgical patient.
- Published
- 2020
18. Peri-operative management of the surgical patient with diabetes 2015: Association of Anaesthetists of Great Britain and Ireland
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Barker, P., Creasey, P. E., Dhatariya, K., Levy, N., Lipp, A., Nathanson, M. H., Penfold, N., Watson, B., and Woodcock, T.
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- 2015
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19. Pharmacotherapy for type 2 diabetes in very elderly patients: practicing nihilism or pragmatism?
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Dhatariya, K.
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- 2015
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20. Admission blood glucose helps predict 1 year, but not 2 years, mortality in an unselected cohort of acute general medical admissions
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Haddadin, F., Clark, A., Evans, N., and Dhatariya, K.
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- 2015
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21. Determining in-patient diabetes treatment satisfaction in the UK—the DIPSat study
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Rutter, C. L., Jones, C., Dhatariya, K. K., James, J., Irvine, L., Wilson, E. C. F., Singh, H., Walden, E., Holland, R., Harvey, I., Bradley, C., and Sampson, M. J.
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- 2013
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22. An antibiotic formulary for a tertiary care foot clinic: admission avoidance using intramuscular antibiotics for borderline foot infections in people with diabetes
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Gooday, C., Hallam, C., Sieber, C., Mtariswa, L., Turner, J., Schelenz, S., Murchison, R., Messenger, G., Morrow, D., Hutchinson, R., Williams, H., and Dhatariya, K.
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- 2013
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23. II. Does dexamethasone-induced hyperglycaemia contribute to postoperative morbidity and mortality?
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Dhatariya, K.
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- 2013
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24. NHS Diabetes guideline for the perioperative management of the adult patient with diabetes
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Dhatariya, K., Levy, N., Kilvert, A., Watson, B., Cousins, D., Flanagan, D., Hilton, L., Jairam, C., Leyden, K., Lipp, A., Lobo, D., Sinclair-Hammersley, M., and Rayman, G.
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- 2012
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25. Rhizobium radiobacter wound infection in a patient with diabetes—fact, factitious or just plain unlucky?
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Dhatariya, K., Gooday, C., Morrow, D., Murchison, R., Turner, J., Hutchinson, R., and Williams, H.
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- 2012
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26. Response to Taylor. Insulin dose requirement in diabetic ketoacidosis
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Savage, M. W., Dhatariya, K., Kilvert, A., Courtney, H., Hammersley, M., Rees, A., Hilton, L., and Rayman, G.
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- 2012
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27. The new NHS Diabetes guidelines on the perioperative management of people with diabetes
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Dhatariya, K and Kilvert, A
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- 2011
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28. Joint British Diabetes Societies guideline for the management of diabetic ketoacidosis
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Savage, M. W., Dhatariya, K. K., Kilvert, A., Rayman, G., Rees, J. A. E., Courtney, C. H., Hilton, L., Dyer, P. H., and Hamersley, M. S.
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- 2011
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29. How much do patients attending a secondary care diabetes clinic know about the safe principles of driving?: A55 (P273)
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Seyani, C and Dhatariya, K K
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- 2011
30. Dexamethasone therapy in COVID‐19 patients: implications and guidance for the management of blood glucose in people with and without diabetes
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Rayman, G., primary, Lumb, A. N., additional, Kennon, B., additional, Cottrell, C., additional, Nagi, D., additional, Page, E., additional, Voigt, D., additional, Courtney, H. C., additional, Atkins, H., additional, Higgins, K., additional, Platts, J., additional, Dhatariya, K., additional, Patel, M., additional, Newland‐Jones, P., additional, Narendran, P., additional, Kar, P., additional, Burr, O., additional, Thomas, S., additional, and Stewart, R., additional
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- 2020
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31. Guidelines for the management of diabetes in care homes during the Covid‐19 pandemic
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Sinclair, A., primary, Dhatariya, K., additional, Burr, O., additional, Nagi, D., additional, Higgins, K., additional, Hopkins, D., additional, Patel, M., additional, Kar, P., additional, Gooday, C., additional, Howarth, D., additional, Abdelhafiz, A., additional, Newland‐Jones, P., additional, and O’Neill, S., additional
- Published
- 2020
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32. New Guidance on Managing Inpatient Hyperglycaemia during the COVID‐19 Pandemic
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Rayman, G., primary, Lumb, A., additional, Kennon, B., additional, Cottrell, C., additional, Nagi, D., additional, Page, E., additional, Voigt, D., additional, Courtney, H., additional, Atkins, H., additional, Platts, J., additional, Higgins, K., additional, Dhatariya, K., additional, Patel, M., additional, Narendran, P., additional, Kar, P., additional, Newland‐Jones, P., additional, Stewart, R., additional, Burr, O., additional, and Thomas, S., additional
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- 2020
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33. Guidance on the management of Diabetic Ketoacidosis in the exceptional circumstances of the COVID‐19 pandemic
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Rayman, G., primary, Lumb, A., additional, Kennon, B., additional, Cottrell, C., additional, Nagi, D., additional, Page, E., additional, Voigt, D., additional, Courtney, H., additional, Atkins, H., additional, Platts, J., additional, Higgins, K., additional, Dhatariya, K., additional, Patel, M., additional, Narendran, P., additional, Kar, P., additional, Newland‐Jones, P., additional, Stewart, R., additional, Burr, O., additional, and Thomas, S., additional
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- 2020
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34. Pale retinal vessels in newly diagnosed type 2 diabetes
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Gaur, S., primary, Bawden, D., additional, and Dhatariya, K. K., additional
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- 2020
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35. ABCD position statement on the management of hypogonadal males with type 2 diabetes
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Dhatariya, K, Nagi, D, and Jones, TH
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- 2010
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36. Psychometric validation and use of a novel diabetes in-patient treatment satisfaction questionnaire
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Sampson, M. J., Singh, H., Dhatariya, K. K., Jones, C., Walden, E., and Bradley, C.
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- 2009
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37. Good with numbers: a professorʼs own HbA1c prediction
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Dhatariya, K
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- 2009
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38. Abnormal liver function tests and diabetes mellitus - a secondary care prevalence study: A97
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Kejariwal, D, Scovell, L, Freeman, K, Phillips, M, and Dhatariya, K
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- 2008
39. METASTATIC HÜRTHLE CELL CARCINOMA PRESENTING WITH LOW FREE THYROXINE, SEVERE HYPERCALCEMIA AND SPURIOUS GROWTH HORMONE PRODUCTION
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Rehman, S. and Dhatariya, K. K.
- Subjects
Case Reports - Abstract
Objective: Hürthle cell tumors constitute about 5% of thyroid neoplasms. They have malignant potential, behaving very aggressively compared to other differentiated thyroid cancers. The objective of this case report is to describe a case of a Hürthle cell carcinoma with a single large metastasis in the liver presenting almost 17 years after hemithyroidectomy. We highlight the difficulties in making a histologic diagnosis and the unpredictable nature of this cancer. Methods: The patient history and biochemistry were detailed. Thyroid function tests analyzed on multiple platforms (single-photon emission computed tomography, dynamic magnetic resonance imaging, technetium-99m bone scan, and radioactive iodine) were used to aid biochemical and radiologic diagnosis. Results: The patient's thyroid function test showed persistently low free thyroxine concentrations with normal thyroid stimulating hormone and free triiodothyronine, suggesting rapid deiodination in the context of a large liver lesion. Radiologic and morphologic appearances of the liver lesion led to an initial misdiagnosis of primary hepato-cellular carcinoma, revised to metastatic Hürthle cell carcinoma after positive immunochemistry. Nonparathyroid hormone-related intractable hypercalcemia of malignancy with an unusual pattern of elevated 1,25-dihydroxyvitamin D and raised fibroblast growth factor 23 concentrations culminated in his demise. Conclusions: In Hürthle cell carcinomas treated with partial thyroidectomy, subsequent abnormal thyroid functions tests may herald a more sinister underlying diagnosis. The management of Hürthle cell carcinoma relies heavily on the initial histology results. Histologic diagnosis should be sought earlier in abnormal and suspicious distant masses. Malignant hypercalcemia poses a great challenge in delayed presentations and can prove resistant to conventional treatments.
- Published
- 2019
40. A national survey of in-patient diabetes services in the United Kingdom
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Sampson, M. J., Brennan, C., Dhatariya, K., Jones, C., and Walden, E.
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- 2007
41. Trends in bed occupancy for inpatients with diabetes before and after the introduction of a diabetes inpatient specialist nurse service
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Sampson, M. J., Crowle, T., Dhatariya, K., Dozio, N., Greenwood, R. H., Heyburn, P. J., Jones, C., Temple, R. C., and Walden, E.
- Published
- 2006
42. Perioperative nutrition : Recommendations from the ESPEN expert group
- Author
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Lobo, D. N., Gianotti, L., Adiamah, A., Barazzoni, R., Deutz, N. E. P., Dhatariya, K., Greenhaff, P. L., Hiesmayr, M., Hjort Jakobsen, D., Klek, S., Krznaric, Z., Ljungqvist, Olle, McMillan, D. C., Rollins, K. E., Panisic Sekeljic, M., Skipworth, R. J. E., Stanga, Z., Stockley, A., Stockley, R., Weimann, A., Lobo, D. N., Gianotti, L., Adiamah, A., Barazzoni, R., Deutz, N. E. P., Dhatariya, K., Greenhaff, P. L., Hiesmayr, M., Hjort Jakobsen, D., Klek, S., Krznaric, Z., Ljungqvist, Olle, McMillan, D. C., Rollins, K. E., Panisic Sekeljic, M., Skipworth, R. J. E., Stanga, Z., Stockley, A., Stockley, R., and Weimann, A.
- Abstract
Background & aims: Malnutrition has been recognized as a major risk factor for adverse postoperative outcomes. The ESPEN Symposium on perioperative nutrition was held in Nottingham, UK, on 14–15 October 2018 and the aims of this document were to highlight the scientific basis for the nutritional and metabolic management of surgical patients. Methods: This paper represents the opinion of experts in this multidisciplinary field and those of a patient and caregiver, based on current evidence. It highlights the current state of the art. Results: Surgical patients may present with varying degrees of malnutrition, sarcopenia, cachexia, obesity and myosteatosis. Preoperative optimization can help improve outcomes. Perioperative fluid therapy should aim at keeping the patient in as near zero fluid and electrolyte balance as possible. Similarly, glycemic control is especially important in those patients with poorly controlled diabetes, with a stepwise increase in the risk of infectious complications and mortality per increasing HbA1c. Immobilization can induce a decline in basal energy expenditure, reduced insulin sensitivity, anabolic resistance to protein nutrition and muscle strength, all of which impair clinical outcomes. There is a role for pharmaconutrition, pre-, pro- and syn-biotics, with the evidence being stronger in those undergoing surgery for gastrointestinal cancer. Conclusions: Nutritional assessment of the surgical patient together with the appropriate interventions to restore the energy deficit, avoid weight loss, preserve the gut microbiome and improve functional performance are all necessary components of the nutritional, metabolic and functional conditioning of the surgical patient., Funding Agency:European Society for Clinical Nutrition and Metabolism (ESPEN), Luxemborg
- Published
- 2020
- Full Text
- View/download PDF
43. Portal vein thrombosis despite anticoagulation in a person with diabetes
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Schweigart, J H, Klotsas, A, Schelenz, S, and Dhatariya, K
- Published
- 2005
44. Correction
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Nathanson, M. H., primary and Dhatariya, K., additional
- Published
- 2019
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45. Liraglutide and Renal Outcomes in Type 2 Diabetes
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Mann JFE, Ørsted DD, Brown-Frandsen K, Marso SP, Poulter NR, Rasmussen S, Tornøe K, Zinman B, Buse JB, LEADER Steering Committee and Investigators. Bergenstal R, Daniels G, Moses AC, Nauck M, Nissen S, Pocock S, Steinberg W, Stockner M, Kristensen P, Ravn LS, Zychma M, Flyvbjerg A, Ford I, Kloos RT, Schactman MJ, Sleight P, Swedberg K, Tenner SM, Akalın S, Arechavaleta R, Bain S, Babkowski MC, Benroubi M, Berard L, Comlekci A, Czupryniak L, Eliasson B, Eriksson M, Fonseca V, Franek E, Gross J, Hafidh K, Haluzik M, Hayes F, Huang YY, Jacob S, Kaddaha G, Khalil A, Kilhovd B, Laakso M, Leiter L, Lalic N, Ji L, Luedemann J, Mannucci E, Marre M, Masmiquel L, Mota M, Omar M, O’Shea D, Pan C, Petrie J, Pieber T, Pratley R, Raz I, Rea R, Rutten G, Satman I, Shestakova M, Simpson R, Smith D, Tack C, Tarnow L, Thomas N, Van Gaal L, Travert F, Vidal J, Warren M, Yoon KH, Tuttle RM, Sheerman SI, Hegedüs L, Baerwald H, Bergenstal M, Celik S, Dias C, Eder M, Fitzgibbons S, Irvhage L, Kloluckova J, Kriulianski R, McDuffie R, Moen S, Paster A, Saalfeld RM, Sankar K, Shehaj E, Swierzewska P, Tiktin M, Tovey S, Gibson CM, Chakrabarti AK, Dashe JF, 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E, Martinez G, Martinez-Miss S, Marx P, Massara L, Mastoor M, Matfin G, Maturu A, Maurides P, May M, Mayfield R, Maynard B, Mazza A, McCann K, McCoy J, McCoy T, McCullen MK, McDaniel C, McDaniel AM, McDermott M, McDonald A, McMasters B, McMurray C, Medlin T, Meinel M, Mendez I, Menefee J, Meredith M, Merriweather M, Mersey J, Messino C, Meyer S, Meyers L, Michael D, Midyett C, Miklius A, Milford E, Miller B, Miller H, Milligan M, Minor A, Miranda-Palma B, Mirarchi N, Mittadodla S, Mittle J, Moffat A, Mohaupt S, Mohiuddin K, Mokshagundam S, Monaco S, Monsaert R, Montano-Pereira C, Montgomery A, Moody K, Moon M, Moore D, Moore L, Morawski E, Moreau C, Morin D, Moscoa C, Motzkin C, Mueller R, Munoz C, Munoz M, Myneni A, Naderi B, Nagireddy P, Naidu J, Naidu R, Naik S, Naimark R, Nardicchi M, Ndukwu I, Neller C, Netten-Foster L, Neumiller J, New T, Newman S, Newton T, Nguyen B, Nicol B, Nicol P, Ninivaggi L, Niswender K, Norman L, Noworatzky G, Nyenwe E, O'Brien H, O'Connell T, Oden W, Odugbesan A, Oliver M, Oliver T, Olmeda C, O'Neil C, Oremus R, Ortega T, Ortiz-Santos S, Osborn T, Padmanabhan S, Papacostea O, Park I, Parker A, Parker K, Parker R, Patel C, Patel M, Patel R, Patino M, Patterson S, Paulson K, Paz A, Pemba R, Pepe C, Perez J, Perez T, Perry D, Phillips B, Phillips J, Pickett A, Pinson M, Pitzer R, Poduri M, Poehls J, Poteat T, Powell L, Prasad S, Prevost J, Price E, Priest D, Prieto L, Purewal T, Purighalla R, Purighalla U, Quadrel M, Qureshi A, Radhamma R, Rafla E, Rajab H, Ramalingam R, Ramirez A, Ramirez J, Ramirez K, Ramirez M, Randall M, Rangaraj U, Rao V, Rasmussen P, Rasouli N, Ray A, Reed J, Rems L, Renaud K, Reno M, Resnick M, Reusch J, Reynolds L, Rhoton K, Rhudy J, Ricci C, Rice L, Richardson A, Richardson L, Rickard H, Rickels M, Riff D, Rightenour N, Risser J, Rizvi A, Robertson J, Robinson A, Robinson R, Rockwell M, Rodriguez JP, Rodriguez M, Rojas M, Rojas W, Rooker-Morris L, Root C, Rose M, Rosenberg R, Rosenstock J, Roth M, Ruby R, Sachson R, Sack P, Sadler RK, Sahai S, Salazar J, Salgam M, Samal A, Samson A, Sanagorski R, Sanchez A, Sandberg J, Sanderson M, Sandoval J, Santiago E, Sapp T, Saunders J, Schill J, Schott C, Schreiman R, Schu D, Schuh K, Schutta M, Schwartz J, Schweppe L, Scofield H, Scribner A, Seal J, Sealock J, Seaton B, Sedlak-Hanslik T, Seekins K, Segal M, Seggelke S, Semenza S, Sentman P, Serra M, Seshadri P, Sevilla E, Shah S, Shaheen K, Shanik M, Shaw J, Sheets M, Shellabarger C, Sher J, Shippey J, Shivaswamy V, Shomali M, Shore D, Shroff P, Siddiqui T, Siegwald A, Silver R, Simmons D, Simons R, Sinan A, Singh M, Sirinvaravong S, Skero J, Slover-Zipf J, Small S, Smith B, Smith K, Smith M, Sohl J, Solarz SH, Soler D, Sood A, Sora N, Souchet A, Soule J, Sparks J, Spector L, Speicher R, Spillers L, Spivey T, Springer N, Sprouse H, St John J, Stacey A, Stacey H, Stafford M, Stagner E, Staples K, Steadman E, Steed R, Steeves G, Steinberg H, Stell C, Stirman E, Straub K, Strock E, Sue M, Suris O, Sutton T, Tabbah I, Talsania M, Tang R, Tapia J, Taylor K, Taylor-Hancher R, Teator R, Tekateka M, Temple B, Temple K, Teodori M, Tharp P, Thethi T, Theuma P, Thomas S, Thottan A, Thrasher J, Thrasher L, Tiemeyer M, Tinney I, Tobin T, Toma S, Tovar M, Townsend J, Trantow C, Traylor H, Trevino M, Troy M, Trumper D, Tryggestad J, Tucker C, Turner J, Turney R, Tuten C, Tyzack J, Ullo L, Underkofler C, Unger J, Urdanetta R, Valdivia V, Valenti S, Vanderheiden A, Vanderlinde-Wood M, Varma C, Vasquez E, Vazquez M, Vickery D, Villafuerte B, Villegas C, Vivar J, Vivekananthan K, Vo G, Vukojicic K, Wachter A, Wahl D, Waitmann J, Walker D, Walsh J, Walsh K, Walton A, Wang A, Wardell K, Watkins S, Watkinson J, Watts M, Watwe V, Weaver N, Weber R, Wedick C, Weeks D, Weeks L, Weindorff K, Weinstein R, Weiss S, Wenger K, Wentworth M, Werner A, West M, Whelan S, White B, White J, Whitmire M, Whittington R, Wical J, Wigley C, Wilkins F, Will K, Williams A, Wilson LE, Wince M, Wine S, Winkle P, Winner C, Wise J, Witte M, Wittenmyer J, Wood C, Wood R, Woodruff C, Worthington B, Wynn D, Wysham C, Xavier P, Yela S, Yenoby L, Young L, Younus N, Yourell V, Zaid M, Zubair I., Mann, Jfe, Ørsted, Dd, Brown-Frandsen, K, Marso, Sp, Poulter, Nr, Rasmussen, S, Tornøe, K, Zinman, B, Buse, Jb, Bergenstal R, LEADER Steering Committee and Investigators., Daniels, G, Moses, Ac, Nauck, M, Nissen, S, Pocock, S, Steinberg, W, Stockner, M, Kristensen, P, Ravn, L, Zychma, M, Flyvbjerg, A, Ford, I, Kloos, Rt, Schactman, Mj, Sleight, P, Swedberg, K, Tenner, Sm, Akalın, S, Arechavaleta, R, Bain, S, Babkowski, Mc, Benroubi, M, Berard, L, Comlekci, A, Czupryniak, L, Eliasson, B, Eriksson, M, Fonseca, V, Franek, E, Gross, J, Hafidh, K, Haluzik, M, Hayes, F, Huang, Yy, Jacob, S, Kaddaha, G, Khalil, A, Kilhovd, B, Laakso, M, Leiter, L, Lalic, N, Ji, L, Luedemann, J, Mannucci, E, Marre, M, Masmiquel, L, Mota, M, Omar, M, O’Shea, D, Pan, C, Petrie, J, Pieber, T, Pratley, R, Raz, I, Rea, R, Rutten, G, Satman, I, 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Resnick, M, Reusch, J, Reynolds, L, Rhoton, K, Rhudy, J, Ricci, C, Rice, L, Richardson, A, Richardson, L, Rickard, H, Rickels, M, Riff, D, Rightenour, N, Risser, J, Rizvi, A, Robertson, J, Robinson, A, Robinson, R, Rockwell, M, Rodriguez, Jp, Rodriguez, M, Rojas, M, Rojas, W, Rooker-Morris, L, Root, C, Rose, M, Rosenberg, R, Rosenstock, J, Roth, M, Ruby, R, Sachson, R, Sack, P, Sadler, Rk, Sahai, S, J, Salazar, Salgam, M, Samal, A, Samson, A, Sanagorski, R, Sanchez, A, Sandberg, J, Sanderson, M, Sandoval, J, Santiago, E, Sapp, T, Saunders, J, Schill, J, Schott, C, Schreiman, R, Schu, D, Schuh, K, Schutta, M, Schwartz, J, Schweppe, L, Scofield, H, Scribner, A, Seal, J, Sealock, J, Seaton, B, Sedlak-Hanslik, T, Seekins, K, Segal, M, Seggelke, S, Semenza, S, Sentman, P, Serra, M, Seshadri, P, Sevilla, E, Shah, S, Shaheen, K, Shanik, M, Shaw, J, Sheets, M, Shellabarger, C, Sher, J, Shippey, J, Shivaswamy, V, Shomali, M, Shore, D, Shroff, P, Siddiqui, T, Siegwald, A, Silver, R, Simmons, D, Simons, R, Sinan, A, Singh, M, Sirinvaravong, S, Skero, J, Slover-Zipf, J, Small, S, Smith, B, Smith, K, Smith, M, Sohl, J, Solarz, Sh, Soler, D, Sood, A, Sora, N, Souchet, A, Soule, J, Sparks, J, Spector, L, Speicher, R, Spillers, L, Spivey, T, Springer, N, Sprouse, H, St John, J, Stacey, A, Stacey, H, Stafford, M, Stagner, E, Staples, K, Steadman, E, Steed, R, Steeves, G, Steinberg, H, Stell, C, Stirman, E, Straub, K, Strock, E, Sue, M, Suris, O, Sutton, T, Tabbah, I, Talsania, M, Tang, R, Tapia, J, Taylor, K, Taylor-Hancher, R, Teator, R, Tekateka, M, Temple, B, Temple, K, Teodori, M, Tharp, P, Thethi, T, Theuma, P, Thomas, S, Thottan, A, Thrasher, J, Thrasher, L, Tiemeyer, M, Tinney, I, Tobin, T, Toma, S, Tovar, M, Townsend, J, Trantow, C, Traylor, H, Trevino, M, Troy, M, Trumper, D, Tryggestad, J, Tucker, C, Turner, J, Turney, R, Tuten, C, Tyzack, J, Ullo, L, Underkofler, C, Unger, J, Urdanetta, R, Valdivia, V, Valenti, S, Vanderheiden, A, Vanderlinde-Wood, M, Varma, C, Vasquez, E, Vazquez, M, Vickery, D, Villafuerte, B, Villegas, C, Vivar, J, Vivekananthan, K, Vo, G, Vukojicic, K, Wachter, A, Wahl, D, Waitmann, J, Walker, D, Walsh, J, Walsh, K, Walton, A, Wang, A, Wardell, K, Watkins, S, Watkinson, J, Watts, M, Watwe, V, Weaver, N, Weber, R, Wedick, C, Weeks, D, Weeks, L, Weindorff, K, Weinstein, R, Weiss, S, Wenger, K, Wentworth, M, Werner, A, West, M, Whelan, S, White, B, White, J, Whitmire, M, Whittington, R, Wical, J, Wigley, C, Wilkins, F, Will, K, Williams, A, Wilson, Le, Wince, M, Wine, S, Winkle, P, Winner, C, Wise, J, Witte, M, Wittenmyer, J, Wood, C, Wood, R, Woodruff, C, Worthington, B, Wynn, D, Wysham, C, Xavier, P, Yela, S, Yenoby, L, Young, L, Younus, N, Yourell, V, Zaid, M, Zubair, I., Mann J.F.E., Orsted D.D., Brown-Frandsen K., Marso S.P., Poulter N.R., Rasmussen S., Tornoe K., Zinman B., Buse J.B., and Buscemi S.
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Male ,Settore MED/09 - Medicina Interna ,Acute Kidney Injury ,Aged ,Albuminuria ,Creatinine ,Diabetes Mellitus, Type 2 ,Diabetic Nephropathies ,Double-Blind Method ,Female ,Follow-Up Studies ,Glomerular Filtration Rate ,Glucagon-Like Peptide 1 ,Humans ,Hypoglycemic Agents ,Intention to Treat Analysis ,Kidney Failure, Chronic ,Liraglutide ,Middle Aged ,Type 2 diabetes ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,GLOMERULAR-FILTRATION-RATE ,KIDNEY-FUNCTION ,DISEASE ,law.invention ,Kidney Failure ,chemistry.chemical_compound ,0302 clinical medicine ,Randomized controlled trial ,law ,Medicine ,Settore MED/49 - Scienze Tecniche Dietetiche Applicate ,Chronic ,RISK ,Kidney ,Acute kidney injury ,11 Medical And Health Sciences ,General Medicine ,medicine.anatomical_structure ,TRIAL ,liraglutide, randomized controlled trial, type 2 diabetes, renal outcomes ,Life Sciences & Biomedicine ,Type 2 ,medicine.drug ,medicine.medical_specialty ,Renal function ,030209 endocrinology & metabolism ,CARDIOVASCULAR OUTCOMES ,Follow-Up Studie ,03 medical and health sciences ,Medicine, General & Internal ,General & Internal Medicine ,Diabetes mellitus ,Internal medicine ,Diabetes Mellitus ,Intensive care medicine ,Science & Technology ,business.industry ,MORTALITY ,medicine.disease ,INTENSIVE GLUCOSE CONTROL ,INDIVIDUALS ,chemistry ,Diabetic Nephropathie ,LEADER Steering Committee and Investigators ,business - Abstract
BACKGROUND: In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks of the primary end point (nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes) and death. However, the long-term effects of liraglutide on renal outcomes in patients with type 2 diabetes are unknown. METHODS: We report the prespecified secondary renal outcomes of that randomized, controlled trial in which patients were assigned to receive liraglutide or placebo. The secondary renal outcome was a composite of new-onset persistent macroalbuminuria, persistent doubling of the serum creatinine level, end-stage renal disease, or death due to renal disease. The risk of renal outcomes was determined with the use of time-to-event analyses with an intention-to-treat approach. Changes in the estimated glomerular filtration rate and albuminuria were also analyzed. RESULTS: A total of 9340 patients underwent randomization, and the median follow-up of the patients was 3.84 years. The renal outcome occurred in fewer participants in the liraglutide group than in the placebo group (268 of 4668 patients vs. 337 of 4672; hazard ratio, 0.78; 95% confidence interval [CI], 0.67 to 0.92; P=0.003). This result was driven primarily by the new onset of persistent macroalbuminuria, which occurred in fewer participants in the liraglutide group than in the placebo group (161 vs. 215 patients; hazard ratio, 0.74; 95% CI, 0.60 to 0.91; P=0.004). The rates of renal adverse events were similar in the liraglutide group and the placebo group (15.1 events and 16.5 events per 1000 patient-years), including the rate of acute kidney injury (7.1 and 6.2 events per 1000 patient-years, respectively). CONCLUSIONS: This prespecified secondary analysis shows that, when added to usual care, liraglutide resulted in lower rates of the development and progression of diabetic kidney disease than placebo. (Funded by Novo Nordisk and the National Institutes of Health; LEADER ClinicalTrials.gov number, NCT01179048 .).
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- 2017
46. The impact of liraglutide on diabetes-related foot ulceration and associated complications in patients with type 2 diabetes at high risk for cardiovascular events: Results from the LEADER trial
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Simpson, R., Tarnow, L., Tornøe, K., Pratley, R.E., Kaltoft, M.S., Stellfeld, M., Buse, J.B., Dhatariya, K., and Bain, S.C.
- Abstract
OBJECTIVE: Diabetes-related foot ulcers (DFUs) and their sequelae result in large patient and societal burdens. Long-term data determining the efficacy of individual glucose-lowering agents on DFUs are lacking. Using existing data from the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial, we conducted post hoc analyses assessing the impact of liraglutide versus placebo in people with type 2 diabetes and at high risk of cardiovascular (CV) events on the incidence of DFUs and their sequelae. RESEARCH DESIGN AND METHODS: The LEADER trial (NCT01179048) was a randomized, double-blind, multicenter, CV outcomes trial assessing liraglutide (1.8 mg/day) versus placebo, in addition to standard of care, for up to 5 years. Information on DFUs was collected systematically during the trial, and DFU complications were assessed post hoc through reviewing case narratives. RESULTS: During a median of 3.8 years' follow-up, similar proportions of patients reported at least one episode of DFU in the liraglutide and placebo groups (3.8% [176/4,668] versus 4.1% [191/4,672], respectively; hazard ratio [HR] 0.92 [95% CI 0.75, 1.13; P = 0.41]). Analysis of DFU-related complications demonstrated a significant reduction in amputations with liraglutide versus placebo (HR 0.65 [95% CI 0.45, 0.95; P = 0.03]). However, no differences were found for foot infections, involvement of underlying structures, or peripheral revascularization in the main analysis. CONCLUSIONS: Treatment with liraglutide in patients with type 2 diabetes and at high risk of CV events in the LEADER trial did not increase the risk of DFU events and was associated with a significantly lower risk of DFU-related amputations compared with placebo. This association, possibly due to chance, needs further investigation.
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- 2018
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47. The cost of treating diabetic ketoacidosis in an adolescent population in the UK: a national survey of hospital resource use
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Dhatariya, K. K., primary, Parsekar, K., additional, Skedgel, C., additional, Datta, V., additional, Hill, P., additional, and Fordham, R., additional
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- 2019
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48. Pre-operative optimisation of the surgical patient with diagnosed and undiagnosed diabetes: a practical review
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Levy, N., primary and Dhatariya, K., additional
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- 2019
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49. Dexamethasone therapy in COVID‐19 patients: implications and guidance for the management of blood glucose in people with and without diabetes.
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Rayman, G., Lumb, A. N., Kennon, B., Cottrell, C., Nagi, D., Page, E., Voigt, D., Courtney, H. C., Atkins, H., Higgins, K., Platts, J., Dhatariya, K., Patel, M., Newland‐Jones, P., Narendran, P., Kar, P., Burr, O., Thomas, S., and Stewart, R.
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BLOOD sugar ,BLOOD sugar monitoring ,DIABETES ,PATIENT aftercare ,INSULIN ,DEXAMETHASONE ,GLYCEMIC control ,COVID-19 - Abstract
The article discusses that high doses of glucocorticoids exacerbate hyperglycaemia in people with diabetes. It mentions that glucocorticoids are the commonest cause of people with diabetes developing potentially life-threating hyperglycaemic hyperosmolar state (HHS) in hospital. It also mentions that COVID-19 infection is associated with significant insulin resistance.
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- 2021
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50. Joint British Diabetes Societies for Inpatient Care (JBDS‐IP) Clinical Guideline Inpatient care of the frail older adult with diabetes: an Executive Summary.
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Sinclair, A. J., Dashora, U., George, S., and Dhatariya, K.
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TREATMENT of diabetes ,CONSENSUS (Social sciences) ,FRAIL elderly ,HEALTH care teams ,HOSPITAL admission & discharge ,PATIENT aftercare ,MEDICAL care ,MEDICAL protocols ,MEDICAL writing ,PATIENTS ,PREOPERATIVE care ,PREVENTIVE health services ,PROFESSIONAL associations ,RISK assessment ,TERMINAL care ,DECISION making in clinical medicine ,COMORBIDITY ,DISCHARGE planning ,FUNCTIONAL assessment - Abstract
We present an Executive Summary of a guideline produced by a Joint British Diabetes Societies for Inpatient Care Writing Group for managing frail older inpatients with diabetes. This represents a multidisciplinary stakeholder consensus document providing more than 100 recommendations in eight areas: functional assessment and detection of frailty; preventative care: assessing risk factors and avoiding hospital admissions; general inpatient management principles; managing therapy choices for the frail older inpatient with diabetes; managing associated comorbidities and concerns; pre‐operative assessment and care; discharge planning and principles of follow‐up; and end of life care. The document is intended to guide effective clinical decision‐making in an inpatient setting and is supported by four appendices: Appendix 1, STOPPFRAIL criteria; Appendix 2, Acute care toolkit 3—Royal College of Physicians; Appendix 3, a description of physical performance and frailty measures for routine NHS application; and Appendix 4, Inpatient Frailty Care Pathway—template. This document is expected to enhance clinical outcomes and overall health status for this vulnerable inpatient population of older people with diabetes. The full version of the guideline, including the appendices, can be found at https://abcd.care/sites/abcd.care/files/resources/Inpatient_Care_of_the_Frail_Older_Adult.pdf [ABSTRACT FROM AUTHOR]
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- 2020
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