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The aim of this study is to analyze and characterize the antimicrobial effect of cerium oxide nanoparticles (NP) synthesized using neem and ginger. Finely grounded neem and ginger powder were taken and mixed with distilled water. This mixture was then heated and filtered. Ammonium cerium nitrate dissolved in distilled water. Both the mixtures were mixed and stirred magnetically. A double-beam ultraviolet-visible spectrophotometer was used to monitor color changes. The extract was centrifuged at 8000 rpm for 15 min. The final pellet was powdered using a hot air oven at 70°C for 24 h. Visualization was done by transmission electron microscopy and spherical morphology was noted, with an average diameter of 5 nm, in aggregated form. The sample containing 100 mg of cerium oxide shows the most significant effect on the zone of inhibition of 11 mm of Staphylococcus aureus. The results obtained in the current study confirmed that CeO-NP possessed antioxidant and cytotoxic properties.

The present invention relates to dental compositions that include a phosphorescent material, more particularly, adding phosphorescent material to waxes that used in dentistry. The aim of the study is to develop a wax that has innate phosphorescent properties. Three groups of samples were taken in which the phosphorescent material was added. Three groups were later compared for their phosphorescent property in the material. All the samples in the initial molten state were poured into a mold made of silicone impression material and allowed to set. The material was placed in a dark room, and visual examination was done to compare the materials. From the samples obtained, paraffin wax showed more phosphorescent property than beeswax. The least phosphorescent property was seen in marginal wax. It can be concluded from this study that paraffin wax showed the most phosphorescent property.

Implant dentistry's emergence and acceptance have provided physicians with a wide range of new options for fixed and removable rehabilitation. The eventual replacement of the lost tooth is the ultimate success, and this can be accomplished using recognized prosthodontic methods. The present study aims to evaluate the time and dimensional accuracy of implant definitive models with an open tray impression with two different techniques. Impression was made in two different techniques and the cast was poured and checked for the time taken and the accuracy of the impression. In IBM SPSS software version 23.0 all the results were statistically analyzed. An Independent t-test was performed for the parameters. No statistically significant difference was present (P > 0.05) when comparing the accuracy and time taken between the two groups. It is concluded that time taken and the misfit is less for modified open tray impression techniques when compared to the regular open tray impression.

Long span base metal alloy fixed prosthesis and partial dental prosthesis frameworks most often require welding for better fit and adaptation. The type of metal alloys used and its effect on the weld strength of the prosthesis have to be investigated. The aim of the study is to comparatively analyze the weld strength of nickel-chromium (Ni-Cr) and cobalt-chromium (Co-Cr) base metal alloys when subjected to tungsten inert gas (TIG) welding. 10 nickel- and cobalt-based specimens were obtained by casting of castable resin patterns of dimension 25 mm × 3 mm × 1 mm. Welding of the samples was carried out using the Lampert PuK 2 welding equipment, and a three-point bend test using a universal testing machine was carried out to evaluate the weld strength of the specimens. Statistical analysis was carried out using the SPSS software version 23. Higher weld strength was observed in the Co-Cr alloy (mean = 898 MPa) than in the Ni-Cr alloy (mean = 690 MPa), when submitted to TIG welding (P < 0.05). TIG welding could be a better alternative for joining base metal alloys for long span edentulous cases, and cobalt-based alloys could be better alternatives to nickel-based alloys that usually tend to cause hypersensitivity reactions.

A goal of modern dentistry is to make an esthetic outcome as one of the major modalities in dental treatment. In recent years, more emphasis has been given to esthetic parameters, especially in the anterior regions. The aim of this study was to evaluate the presence of change in pink and white esthetics scores after giving crowns in a single tooth. Subjects for this retrospective study were chosen by randomization from June 2019 to May 2020. A total of 120 subjects were selected which were equally divided with respect to age and gender. The analysis was done with a photographic assessment. The study test was done using paired t-test, and the correlation was evaluated using the Chi-square test. In this study, we observed that there is an increase in pink and white esthetic scores (WES) after the prosthesis is delivered. There was a clinical and statistically significant difference seen with the WES and total score, whereas only clinical but no statistical difference was seen with the pink esthetic score. After giving crowns, there is an increase in overall esthetic score. It is important to have certain standardized indices to score esthetics by which the overall esthetic outcomes can be improved. One such popular index is the pink and white esthetic index, which scores the soft and hard tissue.

N20 omission or addition to the combination of an opioid and neuroleptic is referred to as neuroleptanalgesia and neuroleptanesthesia, respectively. Conscious sedation is the result of this evolution. The requirement for high-quality anesthesia that is also related with speedier recovery, improved comfort, and lower costs all support the concept of neuroleptanesthesia. A set of eight questions was formulated and circulated among the undergraduate and postgraduate students of Saveetha Dental College. Responses were collected and the data were entered into MS Excel sheet and transferred to SPSS for the analysis. Results were made into graphs and interpreted. In the present study, among the students who took part in the study, 36.3% of the students were postgraduates and 63.7% of them were undergraduates. About 45.2% of the students were not aware and 54.8% of the students were aware that neuroleptanalgesia refers to the combination of a potent sedative analgesic agent and a tranquillizer. Many of the students were not aware of what neuroleptic esthetic is and how it evolved. The current study showed that most students did not have enough knowledge about neurolept anesthesia. However, dentists should make efforts to improve knowledge, awareness of neurolept anesthesia for further advancement, and the need for high-quality anesthesia.

In a partial or entirely independent jaw, oral implantology is a technique in dentistry used to enhance the function of mastication, esthetics, and phonation. An important diagnostic aspect for the effectiveness of implant therapy is the stability of the implants. This study aims to measure dental professionals' and dental students' knowledge of resonance frequency analysis (RFA) in dental implantology. This study aims to measure dental professionals' and dental students' knowledge of RFA in dental implantology. One hundred ninety-nine dentists and dental students participated in an online survey study that was delivered through Google Forms. For statistical analysis, tabulated data from the Excel sheets were transferred into the SPSS program. The Chi-square test is also used to examine clinical relevance. According to the study's findings, 60% of the respondents were male and 46% of those who responded were dental professionals. The respondents were primarily between the ages of 18 and 22 (36%). The majority of dental undergraduates and graduates were found to be knowledgeable about the various techniques used to gauge implant stability (P = 0.04 < 0.05). Within the limitations of this study, it was found that most of the dental students and dental practitioners participating in this study were aware of implant stability. The majority of the respondents were aware that RFA was used to measure primary and secondary stability and osseointegration.

D-dimer molecules are formed by the degradation of cross-linked fibrin during the process of fibrinolysis. The formation of D-dimer requires the activity of activated factor XIII (factor XIIIa), plasmin, and thrombin. To assess the awareness about D-dimer assay among dental students. A cross-sectional study was done among 100 dental practitioners through an online survey. The survey consisted of 10 semiclosed prevalidated and reliable questionnaires based on the knowledge, attitude, and practice of the dentists on D-dimer assay. Descriptive and inferential statistics were performed to report the responses of the participants. Most participants did not know what a D-dimer assay is (55%). Forty-six percent of participants responded that the D-dimer assay is used to rule out serious blood clots. Fifty-four percent of the participants responded that fibrin D-dimers are formed when fibrin strands are formed. The current study shows that the knowledge about D-dimer assay is more in CRRI than in participants of junior year of study. Thus, more rigorous educational programs should be initiated to further enrich the knowledge among dental students.

Abstract Two‐piece hollow bulb obturator maxillofacial prosthesis for hemi‐maxillectomy defect is given after surgical resection due to oral squamous cell carcinoma. Maxillofacial prosthodontists play a pivotal role in construction of prosthesis. Unique choices are made in prosthesis design depending on the clinical representation. Improvement in function, phonetics and esthetics was appreciated.

Neuroblastoma (NB) is a type of peripheral sympathetic nervous system cancer that most commonly affects children. It is caused by the improper differentiation of primitive neural crest cells during embryonic development. Although NB occurs for 8% of paediatric cancers, it accounts for 15% of cancer-related deaths. Despite a considerable increase in cytotoxic chemo- and radiotherapy, patients in advanced stages remain virtually incurable. Therefore, there is a desperate necessity for new treatment strategies to be investigated. Accumulating evidence suggested that microRNAs (miRNAs) are a class of non-coding RNAs with 19–25 nucleotides lengths and play a central role in the development of NB carcinogenesis. Fascinatingly, miRNA inhibitors have an antisense property that can inhibit miRNA function and suppress the activity of mature miRNA. However, many studies have addressed miRNA inhibition in the treatment of NB, but their molecular mechanisms and signalling pathways are yet to be analysed. In this study, we impart the current state of knowledge about the role of miRNA inhibition in the aetiology of NB.

Context: Marginal discrepancy influenced by the choice of processing material used for the ceramic laminate veneers needs to be explored further for better clinical application. Aims: This study aimed to evaluate the amount of cervical and incisal marginal discrepancy associated with different ceramic laminate veneering materials. Settings and Design: This was an experimental, single-blinded, in vitro trial. Subjects and Methods: Ten central incisors were prepared for laminate veneers with 2 mm uniform reduction and heavy chamfer finish line. Ceramic laminate veneers fabricated over the prepared teeth using four different processing materials were categorized into four groups as Group I - aluminous porcelain veneers, Group II - lithium disilicate ceramic veneers, Group III - lithium disilicate-leucite-based veneers, Group IV - zirconia-based ceramic veneers. The cervical and incisal marginal discrepancy was measured using a scanning electron microscope. Statistical Analysis Used: ANOVA and post hoc Tukey honest significant difference (HSD) tests were used for statistical analysis. Results: The cervical and incisal marginal discrepancy for four groups was Group I - 114.6 ± 4.3 μm, 132.5 ± 6.5 μm, Group II - 86.1 ± 6.3 μm, 105.4 ± 5.3 μm, Group III - 71.4 ± 4.4 μm, 91.3 ± 4.7 μm, and Group IV - 123.1 ± 4.1 μm, 142.0 ± 5.4 μm. ANOVA and post hoc Tukey HSD tests observed a statistically significant difference between the four test specimens with regard to cervical marginal discrepancy. The cervical and incisal marginal discrepancy scored F = 243.408, P < 0.001 and F = 180.844, P < 0.001, respectively. Conclusion: This study concluded veneers fabricated using leucite reinforced lithium disilicate exhibited the least marginal discrepancy followed by lithium disilicate ceramic, aluminous porcelain, and zirconia-based ceramics. The marginal discrepancy was more in the incisal region than in the cervical region in all the groups.

Background and Aim: This study was formulated to evaluate and estimate the influence of various denture base resin surface pre-treatments (chemical and mechanical and combinations) upon tensile bond strength between a poly vinyl acetate-based denture liner and a denture base resin. Materials and Methods: A universal testing machine was used for determining the bond strength of the liner to surface pre-treated acrylic resin blocks. The data was analyzed by one-way analysis of variance and the t-test (α =.05). Results: This study infers that denture base surface pre-treatment can improve the adhesive tensile bond strength between the liner and denture base specimens. The results of this study infer that chemical, mechanical, and mechano-chemical pre-treatments will have different effects on the bond strength of the acrylic soft resilient liner to the denture base. Conclusion: Among the various methods of pre-treatment of denture base resins, it was inferred that the mechano-chemical pre-treatment method with air-borne particle abrasion followed by monomer application exhibited superior bond strength than other methods with the resilient liner. Hence, this method could be effectively used to improve bond strength between liner and denture base and thus could minimize delamination of liner from the denture base during function.

The attachment of cells to titanium surfaces is an important phenomenon in the area of clinical implant dentistry. A major consideration in designing implants has been to produce surfaces that promote desirable responses in the cells and tissues. To achieve these requirements, the titanium implant surface can be modified in various ways. This review mainly focuses on the surface topography of dental implants currently in use, emphasizing the association of reported variables with biological outcome.

Background: Carnitine is effective in preventing the accumulation of end products related to lipid peroxidation due to its anti-inflammatory and antioxidant effects. Carnitine also exerts a significant anti-inflammatory role through the downregulation of the nuclear factor kappa beta pathway, which leads to a decrease in the expression of pro-inflammatory cytokines.The aim of the study was to estimate the L-carnitine (L-C) levels in diabetic completely edentulous patients. Materials and Methods: A cross-sectional study was conducted after the selection of 60 samples based on the inclusion and exclusion criteria.The collected saliva samples were utilized to measure the levels of L-C using the sandwich enzyme-linked immunosorbent assay (ELISA) method. One hundred microliters of sample was applied to a particular row of wells and incubated for an hour as part of the sandwich ELISA procedure. After the wells had been cleaned, a second batch of monoclonal L-C was added, and they were once more incubated for an hour. The horseradish peroxidase substrate was then applied after washing the second batch as well. To allow the blue-to-yellow color transition, the wells were kept steady. Following the observation of the color shift, the OD was measured, and the concentration was determined using the sandwich ELISA kit's standard curve as an intercept. The data were statistically analyzed using the independent t-test (significant level P < 0.05) and were tabulated. Results: The L-C levels have higher levels in nondiabetic patients than in diabetic patients. The difference in the baseline mean value between the groups was statistically significant (P = 0.00). Although it is statistically significant (P = 0.00), the mean value for diabetic individuals is 0.19 as opposed to 0.29 for nondiabetic patients. Conclusion: Based on the findings, it can be concluded that L-C improves insulin sensitivity and glucose disposal in diabetic completely edentulous patients. [ABSTRACT FROM AUTHOR]