32 results on '"Dhand, U."'
Search Results
2. Copper Deficiency Myelopathy Can Also Involve the Brain Stem
- Author
-
Kumar, G., primary, Goyal, M.K., additional, Lucchese, S., additional, and Dhand, U., additional
- Published
- 2010
- Full Text
- View/download PDF
3. 88. Primary myocardial involvement in adult patients with myotonic dystrophy
- Author
-
Raja, F.M., primary, Elkhalifa, A., additional, Aggarwal, K.B., additional, and Dhand, U., additional
- Published
- 2008
- Full Text
- View/download PDF
4. 81. Multiple mononeuropathy with MFN2 gene mutation and bariatric surgery
- Author
-
Mettu, K., primary, Raja, F., additional, and Dhand, U., additional
- Published
- 2008
- Full Text
- View/download PDF
5. Muscle involvement during postnatal protein calorie malnutrition and recovery in rhesus monkeys.
- Author
-
Chopra, J. S., Mehta, J., Rana, S. V., Dhand, U. K., and Mehtal, S.
- Published
- 1987
- Full Text
- View/download PDF
6. Evaluation of neuropathy in patients on suramin treatment.
- Author
-
Soliven, Betty, Dhand, Upinder K., Kobayashi, Ken, Arora, Ravinder, Martin, Barbara, Petersen, Michele V., Janisch, Linda, Vogelzang, Nicholas J., Vokes, Everett E., Ratain, Mark J., Soliven, B, Dhand, U K, Kobayashi, K, Arora, R, Martin, B, Petersen, M V, Janisch, L, Vogelzang, N J, Vokes, E E, and Ratain, M J
- Published
- 1997
- Full Text
- View/download PDF
7. Painless Electrodiagnostic Current Perception Threshold and Pain Tolerance Threshold Values in CRPS Subjects and Healthy Controls: A Multicenter Study
- Author
-
Raj, P.P., Chado, H.N., Angst, M., Heavner, J., Dotson, R., Brandstater, M.E., Johnson, B., Parris, W., Finch, P., Shahani, B., Dhand, U., Mekhail, N., Daoud, E., Hendler, N., Somerville, J., Wallace, M., Panchal, S., Glusman, S., Jay, G.W., Palliyath, S., Longton, W., and Irving, G.
- Abstract
The purpose of this study is to evaluate both painless and painful sensory transmission in patients with Complex Regional Pain Syndrome (CRPS) using the automated electrodiagnostic sensory Nerve Conduction Threshold (sNCT) test. This test generates reliable, painless Current Perception Threshold (CPT) and atraumatic Pain Tolerance Threshold (PTT) measures. Standardized CPT and PTT measures using constant alternating current sinusoid waveform stimulus at 3 different frequencies 5 Hz, 250 Hz, and 2 kHz (Neurometer® CPT/C Neurotron, Inc. Baltimore, MD) were obtained from CRPS subjects at a distal phalange of the affected extremity and at an ipsilateral asymptomatic control site. Matched sites were tested on healthy subjects. Detection sensitivities for an abnormal PTT and CPT test were calculated based on specificity of 90% as determined from data obtained from healthy controls. A Spearman rank correlation was used to test for a significant association between presence of allodynia and an abnormal PTT or CPT at any frequency tested. Thirty-six CRPS subjects and 57 healthy controls were tested. The highest detection sensitivity of the PTT test from symptomatic test sites was 63% for the finger and 71% for the toe. PTT abnormalities were also detected, to a lesser degree, at the asymptomatic control site (41% finger control site, 16% toe control site). The highest CPT detection sensitivity at the symptomatic site was 37% for the finger site and 53% for the toe site. CPT abnormalities were also detected at the asymptomatic control site (29% finger control site, 37% toe control site). Eighty-six percent of the CRPS subjects had either a PTT or CPT abnormality at any frequency at the symptomatic site. There was a significant correlation between presence of allodynia and presence of an abnormal CPT and PTT, respectively (P < .01). The correlation coefficient was lower for CPT than for PTT, ie, 0.34 versus 0.6 for the finger and 0.48 versus 0.67 for the toe, respectively. In studied CRPS patients an abnormal PTT was detected with higher sensitivity than an abnormal CPT. Assessing PTT may become a useful electrodiagnostic quantitative sensory test for diagnosing and following the course of neuropathic pain conditions.
- Published
- 2001
- Full Text
- View/download PDF
8. Acquired Aphasia with Epilepsy–Landau-Kleffner Syndrome
- Author
-
Sawhney, I. M. S., primary, Suresh, N., additional, Dhand, U. K., additional, and Chopra, J. S., additional
- Published
- 1988
- Full Text
- View/download PDF
9. Measurement of muscle fiber conduction velocity by surface electromyograph triggered averaging technique.
- Author
-
Fang, Jianjun, Shahani, Bhagwan T., Dhand, Upinder K., Fang, J, Shahani, B T, and Dhand, U K
- Published
- 1996
- Full Text
- View/download PDF
10. Copper deficiency myelopathy can also involve the brain stem.
- Author
-
Kumar G, Goyal MK, Lucchese S, and Dhand U
- Subjects
- Copper deficiency, Dermatitis, Seborrheic pathology, Hair Diseases pathology, Humans, Male, Metabolism, Inborn Errors pathology, Middle Aged, Seizures pathology, Brain Diseases pathology, Brain Stem pathology, Magnetic Resonance Imaging methods, Spinal Diseases pathology
- Published
- 2011
- Full Text
- View/download PDF
11. A new approach to motor unit estimation with surface EMG triggered averaging technique.
- Author
-
Shahani BT, Fang J, and Dhand UK
- Subjects
- Adult, Cell Count, Evoked Potentials, Humans, Middle Aged, Motor Neuron Disease pathology, Motor Neurons cytology, Muscle Contraction physiology, Muscle, Skeletal cytology, Muscle, Skeletal pathology, Research Design, Electromyography statistics & numerical data, Motor Neurons physiology, Muscle, Skeletal physiology
- Abstract
A new method for estimating the number of motor units using a surface EMG triggered averaging technique is described. This method provides an estimation of mean motor unit potential (MUP) amplitude at different levels of contraction, which can be utilized to estimate the number of motor units in a given muscle. Motor unit count estimated in abductor pollicis brevis (APB) muscle of 11 normal healthy subjects ranged from 131 to 371 with a mean of 246 +/- 68. In our preliminary study of patients with lower motor neuron lesions, there was a significant reduction in the number of motor units. We believe our new noninvasive method of motor unit counting is a relatively simple and reproducible physiological technique.
- Published
- 1995
- Full Text
- View/download PDF
12. Serum vitamin E estimation in patients of spinocerebellar degeneration.
- Author
-
Jain A, Dhand U, Prabhakar S, Chopra JS, and Aneeta J
- Abstract
Serum Vitamin E was estimated in twenty two consecutive patients of spinocerebellar degeneration. Serum vitamin levels were found to be normal in all these patients. Role of Vitamin E in spinocerebellar syndrome is discussed.
- Published
- 1993
13. Rotatory seizures.
- Author
-
Meshram CM, Prabhakar S, Sawhney IM, Dhand UK, and Chopra JS
- Subjects
- Adolescent, Adult, Cerebral Cortex diagnostic imaging, Cerebral Cortex physiopathology, Child, Electroencephalography, Female, Humans, Male, Posture, Seizures diagnostic imaging, Seizures physiopathology, Stereotyped Behavior physiology, Tomography, X-Ray Computed, Movement physiology, Seizures diagnosis
- Abstract
We report seven cases of "rotatory seizures" with patients rotating around their axis one or several times. Contralateral EEG foci were localized in frontal and temporal regions. Computed tomography scan of three patients showed no structural lesion.
- Published
- 1992
- Full Text
- View/download PDF
14. Vanishing CT lesions in epilepsy.
- Author
-
Chopra JS, Sawhney IM, Suresh N, Prabhakar S, Dhand UK, and Suri S
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Electroencephalography, Epilepsy cerebrospinal fluid, Epilepsy complications, Epilepsy, Complex Partial complications, Epilepsy, Complex Partial diagnostic imaging, Epilepsy, Tonic-Clonic complications, Epilepsy, Tonic-Clonic diagnostic imaging, Female, Hemiplegia diagnostic imaging, Hemiplegia etiology, Humans, Male, Middle Aged, Tomography, X-Ray Computed, Epilepsy diagnostic imaging
- Abstract
Experience with computed tomography (CT) in patients with epilepsy has drawn attention to specific type of cerebral lesions widely prevalent in this part of the world. The lesions disappear spontaneously while patients receive only anticonvulsant therapy. The exact nature of these lesions is not yet understood. One-hundred and twenty-two such patients (M 77; F 45) were studied. Their age ranged from 3 to 57 (mean 21.8 +/- 12.7) years. Seizures were partial motor in 86 (70.5%), generalised tonic clonic in 31 (25.4%), complex partial in 4 and atonic in one case. Postictal hemiparesis was seen in 6 patients who completely recovered within 5 min to 7 days. One hundred patients underwent EEG examination. It was abnormal in 84 cases; 40 patients showed localisation which correlated with CT findings. Plain CT showed low attenuation lesions in all cases. Morphology on contrast enhancement was ring lesion in 50 (40.9%), disc lesion in 47 (38.5%), target lesion in 3 (2.5%), mixed lesion in 2 (0.8%), no enhancement in 18 (14.8%) and a speck with oedema in 2 (0.8%) cases. All lesions were cerebral, present at cortical-subcortical junction. The first follow-up scan was performed in 78 (63.9%) patients within 6-12 weeks. It showed complete disappearance of the lesion in 47 (60.3%) cases. Reduction in size of the lesion and surrounding oedema was observed in 24 (30.8%) cases. The follow-up scans in these 24 cases revealed disappearance of lesion in 11 cases and almost complete resolution of the lesion with a remaining speck in 13 cases. Cerebrospinal fluid (CSF) was normal in 95 out of 100 cases in which it was performed.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1992
- Full Text
- View/download PDF
15. C-reactive proteins, immunoglobulin profile and mycobacterial antigens in cerebrospinal fluid of patients with pyogenic and tuberculous meningitis.
- Author
-
Vaishnavi C, Dhand UK, Dhand R, Agnihotri N, and Ganguly NK
- Subjects
- Humans, Immunoglobulin A cerebrospinal fluid, Immunoglobulin G cerebrospinal fluid, Immunoglobulin M cerebrospinal fluid, Mycobacterium tuberculosis immunology, Antigens, Bacterial cerebrospinal fluid, C-Reactive Protein cerebrospinal fluid, Meningitis cerebrospinal fluid, Tuberculosis, Meningeal cerebrospinal fluid
- Abstract
Cerebrospinal fluid (CSF) samples were collected from 12 patients with pyogenic meningitis (PM), 19 with tuberculous meningitis (TBM), 20 with clinically suspected but not definitely proved cases of tuberculous meningitis (STBM) and 12 normal controls. C-reactive proteins, immunoglobulins G, A, M and mycobacterial antigens were estimated in the CSF samples. Seven out of 51 (13.7%) samples obtained from the patient groups were positive for CRP. Immunoglobulins M and A were significantly raised in the PM group. When the TBM and STBM groups were compared with the controls a highly significant increase was obtained for all immunoglobulins. Mycobacterial antigens/epitopes were identified in 36.8% samples with TBAGB1 and TB68-H monoclonals and in 26.3% with WTB72-A2. In case of patients with suspected TBM, 6.6% were positive with TBAGB1 and WTB72-A2 and 13.3% with TB68-H. However, non-tuberculous patients also reacted with WTB72-A2 (10.5%) and TB68-H (21.0%). This is, to the authors' knowledge, the first report on the presence of CRP in the CSF. Technique for immunoglobulins in CSF is also updated in this paper. We infer that the monoclonal antibody TBAGB1 and immunoglobulins G and A may be safely considered as diagnostic markers of TBM. Estimation of CRP in CSF samples may be made to give a preliminary or additional diagnosis of meningitis regardless of its aetiology.
- Published
- 1992
16. Phrenic neuropathy in arsenic poisoning.
- Author
-
Bansal SK, Haldar N, Dhand UK, and Chopra JS
- Subjects
- Adult, Electromyography, Humans, Male, Neural Conduction, Peripheral Nervous System Diseases chemically induced, Peripheral Nervous System Diseases diagnosis, Poisoning diagnosis, Poisoning therapy, Respiration Disorders chemically induced, Arsenic Poisoning, Phrenic Nerve drug effects, Phrenic Nerve physiopathology
- Abstract
A patient presented with acute arsenic neuropathy with asymmetric bilateral phrenic nerve involvement. The clinical and roentgenographic observations of phrenic nerve dysfunction were confirmed by prolonged phrenic nerve conduction time. The patient made a significant recovery with d-penicillamine therapy.
- Published
- 1991
- Full Text
- View/download PDF
17. Patterns of H-reflex abnormality in patients with low back pain.
- Author
-
Dhand UK, Das SK, and Chopra JS
- Subjects
- Adult, Back Pain diagnosis, Electromyography, Humans, Middle Aged, Reaction Time, Spinal Cord Diseases diagnosis, Spinal Nerve Roots, Back Pain physiopathology, H-Reflex, Spinal Cord Diseases physiopathology
- Abstract
H-reflex was studied in 43 patients with low back pain (including 20 patients with neurological deficit corresponding to S1 radix and 23 patients without deficit) and 20 control subjects. Among patients with neurological deficit the abnormality consisted of absent H-reflex (7 patients), increased H-latency (3 patients), reduced H/M maximal amplitude ratio (5 patients) or a combination of the latter two (2 patients). The H/M ratio was significantly reduced in this group as compared to control subjects and between affected and unaffected sides. Abnormal H-reflex correlated well with ankle jerk hypo- or areflexia, S1 sensory deficit and lumbar myelographic/CT abnormality. In 23 patients without deficit, increased H-latency and/or reduced H/M ratio was observed in 4 cases. Enhanced H/M ratio was noted in only 2 patients of this group. Use of H/M ratio seems to increase the sensitivity of H-reflex in the diagnosis of S1 radiculopathy.
- Published
- 1991
18. Cervical perineurial cyst, a red herring (case report).
- Author
-
Bansal SK, Dhand UK, Khandelwal N, and Chopra JS
- Subjects
- Adult, Diagnosis, Differential, Humans, Male, Myelography, Peripheral Nervous System Diseases diagnosis, Tomography, X-Ray Computed, Cysts diagnosis, Leprosy diagnosis, Nerve Compression Syndromes diagnosis, Spinal Nerve Roots
- Abstract
Leprous mononeuropathy may present without demonstrable maculoanesthetical patches. A case is described in whom wasting of the right hand was initially attributed to C8 T1 entrapment radiculopathy caused by cervical perineurial cysts. On the basis of the benign nature of the perineurial cysts and questionable right ulnar nerve thickening, the patient was given a trial of anti-leprosy drugs. A follow-up clinico-electrophysiological evaluation favored the diagnosis of leprotic ulnar mononeuropathy.
- Published
- 1990
19. Enzyme activities in the sheep placenta during the last three months of pregnancy.
- Author
-
Edwards EM, Rattenbury J, Varnam GC, Dhand UK, Jeacock MK, and Shepherd DA
- Subjects
- Acetoacetates, Alcohol Oxidoreductases metabolism, Animals, Arginase metabolism, DNA metabolism, Female, Gluconeogenesis, Ligases metabolism, Lyases metabolism, Pregnancy, Proteins metabolism, Time Factors, Transferases metabolism, Urea biosynthesis, Placenta enzymology, Pregnancy, Animal, Sheep physiology
- Abstract
In order to assess the extent to which metabolism within the sheep placenta may influence the transfer of metabolites between mother and foetus at different stages of gestation the activities of enzymes concerned with some aspects of carbohydrate, amino acid and keton body metabolism were determined in placental cotyledons resected from ewes during the last three months of pregnancy. The activities of pyruvate kinase (EC 2.7.1.40), lactate dehydrogenase (EC 1.1.1.27), malate dehydrogenase (EC 1.1.1.37), ATP citrate (pro-3S)-lyase (EC 4.1.3.8), citrate (si)-synthase (EC 4.1.3.7), acetyl-CoA synthetase (EC 6.2.1.1), acetyl-CoA acetyltransferase (EC 2.3.1.9) and 3-keto acid CoA-transferase (EC 2.8.3.5) per gram wet weight cotyledon do not change during the period studied. The activities of alanine aminotransferase (EC 2.6.1.2), aspartate aminotransferase (EC 2.6.1.1), isocitrate dehydrogenase (NADP+) (EC 1.1.1.42), ornithine-oxoacid aminotransferase (EC 2.6.1.13) and 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) show an increase in activity between the third and fourth months of pregnancy whilst the activities of arginase (EC 3.5.3.1) and possibly pyruvate carboxylase (EC 6.4.1.1) show an increase in activity between the fourth and final months of pregnancy. Ornithine decarboxylase (EC 4.1.1.17) activity declines to one tenth of its activity during this later period. The absence of detectable activities of phosphoenolpyruvate carboxykinase (EC 4.1.1.32) and ornithine carbamoyltransferase (EC 2.1.3.3) indicate that gluconeogenesis and urea synthesis from ammonia do not occur in the sheep placenta. It appears that the ability of the placenta to metabolise several substrates is achieved by the time the placenta reaches its maximum size at approximately 90 days.
- Published
- 1977
- Full Text
- View/download PDF
20. Lipid composition of the peripheral nerves in malnutrition: an experimental study in young rhesus monkeys.
- Author
-
Rana SV, Mehta S, Chopra JS, Nain CK, Dhand UK, and Mehta J
- Subjects
- Animals, Cholesterol analysis, Glycolipids analysis, Macaca mulatta growth & development, Male, Neural Conduction, Phospholipids analysis, Protein-Energy Malnutrition physiopathology, Disease Models, Animal, Lipids analysis, Macaca metabolism, Macaca mulatta metabolism, Peripheral Nerves analysis, Peripheral Nerves physiopathology, Protein-Energy Malnutrition metabolism
- Abstract
An experimental model of protein calorie malnutrition (PCM) was created in young rhesus monkeys. Ulnar and tibial nerves from six monkeys with PCM, six rehabilitated and 12 control monkeys were studied for lipid composition and activity of myelin marker enzyme. Total lipids, myelin marker lipids and activity of myelin marker enzyme, 2', 3'-cyclic nucleotide 3' - phosphohydrolase were decreased, while esterified cholesterol and free fatty acids were increased in PCM as compared to controls. There was partial recovery in myelin marker lipids and complete restoration of other lipids on nutritional rehabilitation.
- Published
- 1984
21. Postinfectious acute cerebellar ataxia in adults.
- Author
-
Madhusudan M, Sawhney IM, Dhand UK, Prabhakar S, and Chopra JS
- Subjects
- Acute Disease, Adult, Female, Humans, Male, Cerebellar Ataxia etiology, Fever complications
- Published
- 1986
22. Phrenic nerve conduction in leprosy.
- Author
-
Dhand UK, Kumar B, Dhand R, Chopra JS, and Kaur S
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Electromyography, Female, Humans, Male, Middle Aged, Leprosy physiopathology, Neural Conduction, Phrenic Nerve physiopathology
- Abstract
Phrenic nerve conduction was performed bilaterally in 22 multibacillary (BL-LL) and 18 paucibacillary (BT-TT) leprosy patients and 25 control subjects. Prolonged phrenic nerve conduction time and/or reduced amplitude of diaphragm muscle action potential beyond 2.5 standard deviations of control mean values was observed in 9 BL-LL patients (4 bilateral) and 6 BT-TT patients (all unilateral). Out of the nine BL-LL patients with phrenic nerve involvement, median motor and/or sensory nerve conduction was also abnormal in seven patients. On fluoroscopy, diaphragm movements were normal in all patients. The study documents subclinical phrenic nerve involvement in leprosy--a fact not previously recognized.
- Published
- 1988
23. In vitro incorporation of (U-C14)-glucose and (1-C14)-sodium acetate in peripheral nerves of malnourished young rhesus monkeys.
- Author
-
Rana SV, Mehta S, Chopra JS, Nain CK, Mehta J, and Dhand UK
- Subjects
- Acetic Acid, Animals, Animals, Laboratory, Carbon Radioisotopes, Cerebrosides biosynthesis, Cholesterol biosynthesis, Fatty Acids, Nonesterified biosynthesis, In Vitro Techniques, Male, Protein-Energy Malnutrition metabolism, Triglycerides biosynthesis, Acetates metabolism, Glucose metabolism, Lipids biosynthesis, Macaca, Macaca mulatta, Monkey Diseases metabolism, Peripheral Nerves metabolism, Protein-Energy Malnutrition veterinary
- Abstract
The effect of protein calorie malnutrition (PCM) on synthesis of lipids in peripheral nerves was studied by in vitro incorporation of (U-C14)-glucose and (1-C14)-sodium acetate. Ulnar and tibial nerves obtained from five young rhesus monkeys with PCM, five rehabilitated monkeys, and five control monkeys were incubated for 2 h with the radioactive precursors. Uptake of both radioactive precursors in whole peripheral nerves as well as myelin marker lipids was significantly decreased in animals with PCM. However, uptake returned to normal in rehabilitated monkeys.
- Published
- 1984
24. Rett's syndrome.
- Author
-
Dhand UK, Singhi P, and Chopra JS
- Subjects
- Autistic Disorder, Child, Preschool, Female, Hand physiopathology, Humans, Infant, Mouth physiopathology, Sex Factors, Syndrome, Ammonia blood, Intellectual Disability, Movement Disorders
- Published
- 1988
25. Acute cerebellar ataxia in enteric fever.
- Author
-
Sawhney IM, Prabhakar S, Dhand UK, and Chopra JS
- Subjects
- Acute Disease, Adolescent, Adult, Demyelinating Diseases etiology, Female, Humans, Male, Cerebellar Ataxia etiology, Typhoid Fever complications
- Abstract
Acute cerebellar ataxia as an isolated neurological manifestation of enteric fever is very rare. Three cases of acute cerebellar ataxia associated with enteric fever are reported. The diagnosis of enteric fever was confirmed by positive blood culture, strongly positive Widal test and rising antibody titres. The major clinical features were rapid development of gait ataxia, limb ataxia and dysarthria. None of the patients had altered sensorium. The cerebellar involvement was noticed on the second or third day of fever which progressed for one to two days. The symptoms remained static for one to two weeks and thereafter all the patients showed gradual recovery in a few weeks. Acute onset of cerebellar lesion, self limiting course and cerebrospinal fluid pleocytosis suggest par- or post-infectious demyelinating pathology in these patients, who were not related to each other.
- Published
- 1986
- Full Text
- View/download PDF
26. Effect of protein calorie malnutrition on peripheral nerves. A clinical, electrophysiological and histopathological study.
- Author
-
Chopra JS, Dhand UK, Mehta S, Bakshi V, Rana S, and Mehta J
- Subjects
- Child, Preschool, Electromyography, Evoked Potentials, Female, Humans, Infant, Male, Neural Conduction, Peripheral Nerves pathology, Protein-Energy Malnutrition pathology, Sural Nerve pathology, Time Factors, Peripheral Nerves physiopathology, Protein-Energy Malnutrition physiopathology
- Abstract
Forty-three children (aged 7 to 62 months) with protein calorie malnutrition (PCM) were studied; 13 had mild to moderate PCM and 30 severe PCM. A reduction of motor nerve conduction velocity and abnormalities of sensory conduction were present in both groups. The abnormality of motor nerve conduction was directly related to the severity of PCM and the presence of hypotonia and/or hyporeflexia. Sural nerve biopsies from both groups were studied for myelinated fibre density, fibre size spectrum, relationship of internodal length with diameter and qualitative light microscopic changes. The biopsies from children with mild to moderate PCM were characterized by a normal developmental change in myelinated fibres with an increasing proportion of medium and large size fibres, a transition from a unimodal to a bimodal distribution and an appropriate relationship of internodal length to fibre diameter. Evidence of mild segmental demyelination was observed in only one patient of this group. In contrast, in the biopsies from children with severe PCM, the normal developmental pattern for myelinated fibre size distribution was impaired with a persistence of small myelinated fibres, and there was a failure of internodal segments on large fibres to elongate with increase in age and significant segmental demyelination in about 50 per cent of cases. Retarded myelination and segmental demyelination probably form the morphological basis for impaired peripheral nerve function in PCM. Short internodes on large diameter fibres may also contribute to this effect.
- Published
- 1986
- Full Text
- View/download PDF
27. Neurological complications of acute haemorrhagic conjunctivitis.
- Author
-
Chopra JS, Sawhney IM, Dhand UK, Prabhakar S, Naik S, and Sehgal S
- Subjects
- Adolescent, Adult, Aged, Child, Cranial Nerve Diseases etiology, Electromyography, Extremities, Female, HLA Antigens analysis, Humans, Male, Middle Aged, Muscle Hypotonia etiology, Neural Conduction, Paralysis etiology, Peripheral Nerves physiopathology, Urination Disorders etiology, Conjunctivitis, Acute Hemorrhagic complications, Nervous System Diseases etiology
- Abstract
Forty four cases of the neurological complications of acute haemorrhagic conjunctivitis (AHC) seen in India during 1981 epidemic are reported. The disease predominantly affected adult males. The preceding attack of AHC, a latent period, prodromal symptoms of fever, myalgia and root pains followed by acute onset of lower motor neurone paralysis of limbs and/or cranial nerves formed the classical picture of neurological involvement. The recovery was poor and nearly half of the patients remained severely handicapped. Electrophysiological studies showed early appearance of widespread fibrillations and fasciculations, large polyphasic potentials of increased amplitude and reduced interference pattern. Nerve conduction studies were normal in most of the cases. Cerebrospinal fluid (CSF) examination revealed lymphocytic pleocytosis and rise in protein content. Significant antibody titres against enterovirus type 70 (EV 70) were demonstrated in the serum and the CSF. HLA studies showed low occurrence of A2 and B15 HLA antigens. Muscle biopsies revealed neurogenic atrophy and sural nerve biopsies were histologically unremarkable. The similarities of this disease with poliomyelitis and its pathogenesis are discussed.
- Published
- 1986
- Full Text
- View/download PDF
28. Ultrastructure and activity of some enzymes of energy metabolism of skeletal muscle in experimental energy deficiency.
- Author
-
Mehta J, Chopra JS, Mehta S, Nain CK, Bhagwat AG, Dhand UK, and Rana SV
- Subjects
- Animals, Citric Acid Cycle, Creatine Kinase metabolism, Enzymes metabolism, Glycolysis, Macaca mulatta, Male, Microscopy, Electron, Muscles metabolism, Protein-Energy Malnutrition metabolism, Energy Metabolism, Muscles ultrastructure, Protein-Energy Malnutrition pathology
- Abstract
The ultrastructure of skeletal muscle and activity of some enzymes of energy metabolism were studied to assess the effect of a deficiency of dietary energy and subsequent nutritional rehabilitation in 24 young, growing, healthy rhesus monkeys. Electron microscopy of muscles on energy-deficient animals showed thinning of myofibrils with widening of interfibrillar space and enlargement and accumulation of mitochondria at subsarcolemmal level. There was an apparent significant reduction in the fiber size. Muscle samples from each animal were analyzed for enzymes representative of glycolysis (phosphofructokinase [PFK] and lactate dehydrogenase [LDH], citric-acid cycle (isocitric dehydrogenase [ICDH] and citrate synthase [CS] and regeneration of ATP (creatine kinase [CK]. PFK and LDH activities were significantly augmented in energy-deficient animals. The increase in LDH activity resulted from a large increase in MU (skeletal muscle) LDH subunit. The activities of CS and ICDH were reduced. No alteration of CK in muscle and serum was observed. The morphological structure and enzyme activities returned to normal after nutritional rehabilitation.
- Published
- 1987
- Full Text
- View/download PDF
29. Activities of enzymes concerned with pyruvate and oxaloacetate metabolism in the heart and liver of developing sheep.
- Author
-
Edwards EM, Dhand UK, Jeacock MK, and Shepherd DA
- Subjects
- Aging, Animals, Female, Fetus, Gestational Age, Heart growth & development, Liver growth & development, Phosphoenolpyruvate Carboxykinase (GTP) metabolism, Pregnancy, Pyruvate Kinase metabolism, Sheep, Liver enzymology, Myocardium enzymology, Oxaloacetates metabolism, Pyruvates metabolism
- Abstract
1. In order to assess whether the potential ability of heart ventricular muscle and liver to metabolise substrates such as alanine, aspartate and lactate varies as the sheep matures and its nutrition changes, the activities of the following enzymes were determined in tissues of lambs obtained at varying intervals between 50 days after conception to 16 weeks after birth and in livers from adult pregnant ewes: lactate dehydrogenase (EC 1.1.1.27), alanine aminotransferase (EC 2.6.1.2), pyruvate kinase (EC 2.7.1.40), pyruvate carboxylase (EC 6.4.1.1), phosphoenolpyruvate carboxykinase (GTP)(EC 4.1.1.32), malate dehydrogenase (EC 1.1.1.37), aspartate aminotransferase (EC 2.6.1.1) and citrate (si)-synthase (EC 4.1.3.7). 2. In the heart a most marked increase in alanine aminotransferase activity was found throughout development. During this period the activities of citrate (si)-synthase, lactate dehydrogenase and pyruvate carboxylase also increased. There were no substantial changes in the activities of aspartate aminotransferase, malate dehydrogenase or pyruvate kinase. Pyruvate kinase activities were five times greater in the heart compared with those found in the liver. No significant activity of phosphoenolpyruvate carboxykinase (GTP) was detected in heart muscle. 3. In the liver the activities of both alanine aminotransferase and aspartate aminotransferase increased immediately following birth although the activity of alanine aminotransferase was lower in livers of pregnant ewes than in any of the lambs. As with alanine aminotransferase the highest activities of lactate dehydrogenase were found during the period of postnatal growth. No marked changes were observed in malate dehydrogenase or citrate (si)-synthase activities during development. A small decline in pyruvate kinase activity occurred whilst the activities of pyruvate carboxylase and phosphoenolpyruvate carboxykinase (GTP) tended to rise during development.
- Published
- 1975
- Full Text
- View/download PDF
30. Balint's syndrome following eclampsia.
- Author
-
Gurjinder PS, Dhand UK, and Chopra JS
- Subjects
- Adult, Female, Humans, Pregnancy, Radiography, Vision Disorders diagnostic imaging, Vision Disorders physiopathology, Visual Cortex diagnostic imaging, Eclampsia complications, Vision Disorders etiology, Visual Cortex physiopathology
- Abstract
A young female patient sustained bilateral parieto-occipital infarcts and presented with Balint's syndrome following treatment of eclampsia and caesarean section. Altered cerebral blood flow autoregulation and raised intracranial pressure due to eclampsia probably resulted in impaired cerebral perfusion and borderzone cerebral ischaemia in this patient. Careful reduction of blood pressure in patients with eclampsia is emphasized.
- Published
- 1989
- Full Text
- View/download PDF
31. Cyclic esotropia with central nervous system disease: report of two cases.
- Author
-
Pillai P and Dhand UK
- Subjects
- Child, Child, Preschool, Esotropia physiopathology, Humans, Male, Astrocytoma surgery, Cerebral Ventricle Neoplasms surgery, Epilepsy complications, Esotropia etiology, Periodicity, Postoperative Complications, Strabismus etiology
- Abstract
Two cases of cyclic esotropia with associated central nervous system lesions are presented. One had a 48-hour cycle and the other a 24-hour cycle. In the first child, the condition developed after a third ventricular astrocytoma removal and in the second with the advent of an epileptiform disorder. Both were non-accommodative, non-paralytic in nature, and not associated with fusion disrupting factors. These patterns persisted uninterruptedly in one child for 22 months and in the other for more than 8 months until lost for follow-up.
- Published
- 1987
- Full Text
- View/download PDF
32. Activities of enzymes concerned with pyruvate, oxaloacetate, citrate, acetate and acetoacetate metabolism in placental cotyledons of sheep.
- Author
-
Dhand UK, Jeacock MK, Shepherd DA, Smith EM, and Varnam GC
- Subjects
- Alanine Transaminase metabolism, Animals, Aspartate Aminotransferases metabolism, Female, Fetus, Hydroxybutyrate Dehydrogenase metabolism, Isocitrate Dehydrogenase metabolism, L-Lactate Dehydrogenase metabolism, Ligases metabolism, Liver enzymology, Lyases metabolism, Malate Dehydrogenase metabolism, Male, Pregnancy, Pyruvate Kinase metabolism, Sheep, Acetates metabolism, Acetoacetates metabolism, Citrates metabolism, Oxaloacetates metabolism, Placenta enzymology, Pyruvates metabolism
- Published
- 1970
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.