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2. Psoralen Derivatives with Enhanced Potency

Author

Buhimschi, Alexandru D, Gooden, David M, Jing, Hongwu, Fels, Diane R, Hansen, Katherine S, Beyer, Wayne F, Dewhirst, Mark W, Walder, Harold, and Gasparro, Francis P

Subjects
Biological Sciences, Chemical Sciences, Physical Sciences, Cancer, Hematology, Animals, Cell Line, Tumor, DNA, DNA Adducts, Furocoumarins, Mice, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Structure-Activity Relationship, Ultraviolet Rays, Biophysics, Biological sciences, Chemical sciences, Physical sciences
Abstract

Psoralen is a furocoumarin natural product that intercalates within DNA and forms covalent adducts when activated by ultraviolet radiation. It is well known that this property contributes to psoralen's clinical efficacy in several disease contexts, which include vitiligo, psoriasis, graft-versus-host disease and cutaneous T-cell lymphoma. Given the therapeutic relevance of psoralen and its derivatives, we attempted to synthesize psoralens with even greater potency. In this study, we report a library of 73 novel psoralens, the largest collection of its kind. When screened for the ability to reduce cell proliferation, we identified two derivatives even more cytotoxic than 4'-aminomethyl-4,5',8-trimethylpsoralen (AMT), one of the most potent psoralens identified to date. Using MALDI-TOF MS, we studied the DNA adduct formation for a subset of novel psoralens and found that in most cases enhanced DNA binding correlated well with cytotoxicity. Generally, our most potent derivatives contain positively charged substituents, which we believe increase DNA affinity and enhance psoralen intercalation. Thus, we provide a rational approach to guide efforts toward further optimizing psoralens to fully capitalize on this drug class' therapeutic potential. Finally, the structure-activity insights we have gained shed light on several opportunities to study currently underappreciated aspects of psoralen's mechanism.

Published
2020

3. Clinical and Pre-clinical Methods for Quantifying Tumor Hypoxia

Author

Rickard, Ashlyn G., Palmer, Gregory M., Dewhirst, Mark W., COHEN, IRUN R., Editorial Board Member, LAJTHA, ABEL, Editorial Board Member, LAMBRIS, JOHN D., Editorial Board Member, PAOLETTI, RODOLFO, Editorial Board Member, REZAEI, NIMA, Editorial Board Member, and Gilkes, Daniele M., editor

Published
2019
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6. Radioprotection of the Brain White Matter by Mn(III) N-Butoxyethylpyridylporphyrin–Based Superoxide Dismutase Mimic MnTnBuOE-2-PyP5+

Author

Weitzel, Douglas H, Tovmasyan, Artak, Ashcraft, Kathleen A, Rajic, Zrinka, Weitner, Tin, Liu, Chunlei, Li, Wei, Buckley, Anne F, Prasad, Mark R, Young, Kenneth H, Rodriguiz, Ramona M, Wetsel, William C, Peters, Katherine B, Spasojevic, Ivan, Herndon, James E, Batinic-Haberle, Ines, and Dewhirst, Mark W

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Brain Cancer, Brain Disorders, Neurosciences, Rare Diseases, Neurological, Animals, Brain Neoplasms, Cell Line, Tumor, Corpus Callosum, Glioblastoma, Humans, Metalloporphyrins, Mice, Mice, Inbred C57BL, Motor Activity, Oxidative Stress, Radiation-Protective Agents, White Matter, Pharmacology and Pharmaceutical Sciences, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Cranial irradiation is a standard therapy for primary and metastatic brain tumors. A major drawback of radiotherapy (RT), however, is long-term cognitive loss that affects quality of life. Radiation-induced oxidative stress in normal brain tissue is thought to contribute to cognitive decline. We evaluated the effectiveness of a novel mimic of superoxide dismutase enzyme (SOD), MnTnBuOE-2-PyP(5+)(Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin), to provide long-term neuroprotection following 8 Gy of whole brain irradiation. Long-term RT damage can only be assessed by brain imaging and neurocognitive studies. C57BL/6J mice were treated with MnTnBuOE-2-PyP(5+) before and after RT and evaluated three months later. At this time point, drug concentration in the brain was 25 nmol/L. Mice treated with MnTnBuOE-2-PyP(5+)/RT exhibited MRI evidence for myelin preservation in the corpus callosum compared with saline/RT treatment. Corpus callosum histology demonstrated a significant loss of axons in the saline/RT group that was rescued in the MnTnBuOE-2-PyP(5+)/RT group. In addition, the saline/RT groups exhibited deficits in motor proficiency as assessed by the rotorod test and running wheel tests. These deficits were ameliorated in groups treated with MnTnBuOE-2-PyP(5+)/RT. Our data demonstrate that MnTnBuOE-2-PyP(5+) is neuroprotective for oxidative stress damage caused by radiation exposure. In addition, glioblastoma cells were not protected by MnTnBuOE-2-PyP(5+) combination with radiation in vitro. Likewise, the combination of MnTnBuOE-2-PyP(5+) with radiation inhibited tumor growth more than RT alone in flank tumors. In summary, MnTnBuOE-2-PyP(5+) has dual activity as a neuroprotector and a tumor radiosensitizer. Thus, it is an attractive candidate for adjuvant therapy with RT in future studies with patients with brain cancer.

Published
2015

7. Contributors

Author

Aarntzen, Erik, primary, Achilefu, Samuel, additional, Akam, Eman A., additional, Albaghdadi, Mazen, additional, Beer, Ambros J., additional, Bharti, Santosh, additional, Bhujwalla, Zaver M., additional, Bischof, Gérard N., additional, Biswal, Sandip, additional, Boss, Marti, additional, Botnar, René M., additional, Brinson, Zabecca, additional, Brom, Maarten, additional, Buitinga, Mijke, additional, Bulte, Jeff W.M., additional, Caravan, Peter, additional, Chan, Heang-Ping, additional, Chandy, Mark, additional, Chaney, Aisling M., additional, Chen, Delphine L., additional, Chen, Xiaoyuan (Shawn), additional, Chenevert, Thomas L., additional, Coughlin, Jennifer M., additional, Covington, Matthew F., additional, Cumming, Paul, additional, Daldrup-Link, Heike E., additional, Deal, Emily M., additional, de Galan, Bastiaan, additional, Derlin, Thorsten, additional, Dewhirst, Mark W., additional, Di Paolo, Arianna, additional, Drzezga, Alexander, additional, Du, Yong, additional, Thi-Quynh Duong, Mai, additional, Ehman, Richard L., additional, Eriksson, Olof, additional, Galli, Filippo, additional, Gatenby, Robert A., additional, Gelovani, Juri, additional, Giehl, Kathrin, additional, Giger, Maryellen L., additional, Goel, Reema, additional, Gold, Garry, additional, Gotthardt, Martin, additional, Graham, Michael M., additional, Gropler, Robert J., additional, Gründer, Gerhard, additional, Gulhane, Avanti, additional, Hadjiiski, Lubomir, additional, Hajhosseiny, Reza, additional, Hammoud, Dima A., additional, Helfer, Brooke M., additional, Hicks, Rodney J., additional, Higuchi, Takahiro, additional, Hoffman, John M., additional, Honer, Michael, additional, Huang, Sung-Cheng (Henry), additional, Hung, Jessica, additional, Hwang, Do Won, additional, Jackson, Isaac M., additional, Jacobs, Andreas H., additional, Jaffer, Farouc A., additional, Jain, Sanjay K., additional, James, Michelle L., additional, Jansen, Tom, additional, Johansson, Lars, additional, Joosten, Lieke, additional, Kakkad, Samata, additional, Kamson, David, additional, Kang, Sae-Ryung, additional, Kelly, Kimberly A., additional, Knopp, Michelle I., additional, Knopp, Michael V., additional, Kogan, Feliks, additional, Krishnamachary, Balaji, additional, Künnecke, Basil, additional, Lee, Dong Soo, additional, Libby, Peter, additional, Luker, Gary D., additional, Luker, Kathryn E., additional, Makowski, Marcus R., additional, Mankoff, David A., additional, Massoud, Tarik F., additional, Meyer, Charles R., additional, Miller, Zach, additional, Min, Jung-Joon, additional, Mondal, Suman B., additional, Montesi, Sydney B., additional, Navin, Patrick J., additional, Nekolla, Stephan G., additional, Niu, Gang, additional, Notohamiprodjo, Susan, additional, Ordoñez, Alvaro A., additional, Osborn, Eric A., additional, Pacheco-Torres, Jesus, additional, Pagano, Gennaro, additional, Palmer, Gregory M., additional, Paulmurugan, Ramasamy, additional, Penet, Marie-France, additional, Phinikaridou, Alkystis, additional, Pomper, Martin G., additional, Prieto, Claudia, additional, Qi, Haikun, additional, Raghunand, Natarajan, additional, Ramar, Thangam, additional, Reynolds, Fred, additional, Ropella-Panagis, Kathleen, additional, Ross, Brian D., additional, Rowe, Steven P., additional, Rudin, Markus, additional, Sadaghiani, Mohammad S., additional, Sager, Hendrik, additional, Samala, Ravi, additional, Saraste, Antti, additional, Schelhaas, Sonja, additional, Schwaiger, Markus, additional, Schwarz, Sally W., additional, Seiberlich, Nicole, additional, Shapiro, Mikhail G., additional, Shim, Hyunsuk, additional, Signore, Alberto, additional, Solnes, Lilja B., additional, Suh, Minseok, additional, Tsien, Christina, additional, van Eimeren, Thilo, additional, Varasteh, Zohreh, additional, Venkatesh, Sudhakar Kundapur, additional, Viel, Thomas, additional, Waerzeggers, Yannic, additional, Wahl, Richard L., additional, Weber, Wolfgang, additional, Werner, Rudolf A., additional, Winkeler, Alexandra, additional, Wong, Dean F., additional, Wright, Chadwick L., additional, Wu, Anna M., additional, Wu, Joseph C., additional, Yoon, Daehyun, additional, You, Sung-Hwan, additional, Yuan, Chun, additional, Yuan, Hong, additional, Zanzonico, Pat, additional, Zhao, Xue-Qiao, additional, Zhou, Iris Y., additional, and Zinnhardt, Bastian, additional

Published
2021
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12. PET with 62Cu-ATSM and 62Cu-PTSM is a useful imaging tool for hypoxia and perfusion in pulmonary lesions.

Author

Zhang, Tian, Das, Shiva K, Fels, Diane R, Hansen, Katherine S, Wong, Terence Z, Dewhirst, Mark W, and Vlahovic, Gordana

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Biomedical Imaging, Lung, Cancer, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Aged, Coordination Complexes, Cytokines, Female, Fluorodeoxyglucose F18, Humans, Hypoxia, Lung Neoplasms, Male, Middle Aged, Neoplasm Staging, Organometallic Compounds, Positron-Emission Tomography, Radiopharmaceuticals, Survival Rate, Thiosemicarbazones, hypoxia, lung tumor, perfusion, PET, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

ObjectiveHypoxia is a characteristic of many tumors and portends a worse prognosis in lung, cervical, prostate, and rectal cancers. Unlike the others, lung cancers present a unique challenge in measuring hypoxia, with invasive biopsies and higher rates of complications. Noninvasive imaging studies detecting hypoxia using isotopes of copper-diacetyl-bis(N4-methylthiosemicarbazone) ((62)Cu-ATSM) have predicted prognosis and treatment outcomes in some small feasibility trials. These images, however, may not identify all areas of hypoxia. Hence, we hypothesize that the addition of another PET imaging agent, copper-pyruvaldehyde-bis(N4-methylthiosemicarbazone) ((62)Cu-PTSM), which can detect areas of perfusion, can augment the information obtained in (62)Cu-ATSM PET scans.Subjects and methodsTo characterize tumors on the basis of both perfusion and hypoxia, 10 patients were studied using both (62)Cu-ATSM and (62)Cu-PTSM PET scans. In addition, proteomic arrays looking at specific proangiogenic, survival, and proinflammatory targets were assessed.ResultsSix of 10 patients had evaluable PET scans. Our initial experience of characterizing lung tumor hypoxia using (62)Cu-ATSM and (62)Cu-PTSM PET scans showed that visualization of areas with hypoxia normalized for perfusion is feasible. All studied tumors exhibited some hypoxia. Despite the small sample size, a positive relationship was noted between epidermal growth factor levels and (62)Cu-ATSM-detected hypoxia.ConclusionThis initial series of (62)Cu-ATSM and (62)Cu-PTSM PET scans shows that evaluating lung masses by visualizing hypoxia and perfusion is a feasible and novel technique to provide more information. Further investigation is warranted to assess the potential role of (62)Cu-ATSM and (62)Cu-PTSM PET techniques combined with proteomics as alternatives to invasive biopsy techniques in clinical care.

Published
2013

29. A Novel Preclinical Murine Model to Monitor Inflammatory Breast Cancer Tumor Growth and Lymphovascular Invasion

Author

Rickard, Ashlyn G., primary, Sannareddy, Dorababu S., additional, Bennion, Alexandra, additional, Patel, Pranalee, additional, Sauer, Scott J., additional, Rouse, Douglas C., additional, Bouchal, Samantha, additional, Liu, Harrison, additional, Dewhirst, Mark W., additional, Palmer, Gregory M., additional, and Devi, Gayathri R., additional

Published
2023
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30. Figure S1 from E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms

Author

Jolly, Mohit Kumar, primary, Ware, Kathryn E., primary, Xu, Shengnan, primary, Gilja, Shivee, primary, Shetler, Samantha, primary, Yang, Yanjun, primary, Wang, Xueyang, primary, Austin, R. Garland, primary, Runyambo, Daniella, primary, Hish, Alexander J., primary, Bartholf DeWitt, Suzanne, primary, George, Jason T., primary, Kreulen, R. Timothy, primary, Boss, Mary-Keara, primary, Lazarides, Alexander L., primary, Kerr, David L., primary, Gerber, Drew G., primary, Sivaraj, Dharshan, primary, Armstrong, Andrew J., primary, Dewhirst, Mark W., primary, Eward, William C., primary, Levine, Herbert, primary, and Somarelli, Jason A., primary

Published
2023
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31. Supplemental Figure 2 from Radioprotection of the Brain White Matter by Mn(III) N-Butoxyethylpyridylporphyrin–Based Superoxide Dismutase Mimic MnTnBuOE-2-PyP5+

Author

Weitzel, Douglas H., primary, Tovmasyan, Artak, primary, Ashcraft, Kathleen A., primary, Rajic, Zrinka, primary, Weitner, Tin, primary, Liu, Chunlei, primary, Li, Wei, primary, Buckley, Anne F., primary, Prasad, Mark R., primary, Young, Kenneth H., primary, Rodriguiz, Ramona M., primary, Wetsel, William C., primary, Peters, Katherine B., primary, Spasojevic, Ivan, primary, Herndon, James E., primary, Batinic-Haberle, Ines, primary, and Dewhirst, Mark W., primary

Published
2023
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32. Data from Radioprotection of the Brain White Matter by Mn(III) N-Butoxyethylpyridylporphyrin–Based Superoxide Dismutase Mimic MnTnBuOE-2-PyP5+

Author

Weitzel, Douglas H., primary, Tovmasyan, Artak, primary, Ashcraft, Kathleen A., primary, Rajic, Zrinka, primary, Weitner, Tin, primary, Liu, Chunlei, primary, Li, Wei, primary, Buckley, Anne F., primary, Prasad, Mark R., primary, Young, Kenneth H., primary, Rodriguiz, Ramona M., primary, Wetsel, William C., primary, Peters, Katherine B., primary, Spasojevic, Ivan, primary, Herndon, James E., primary, Batinic-Haberle, Ines, primary, and Dewhirst, Mark W., primary

Published
2023
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33. Data from E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms

Author

Jolly, Mohit Kumar, primary, Ware, Kathryn E., primary, Xu, Shengnan, primary, Gilja, Shivee, primary, Shetler, Samantha, primary, Yang, Yanjun, primary, Wang, Xueyang, primary, Austin, R. Garland, primary, Runyambo, Daniella, primary, Hish, Alexander J., primary, Bartholf DeWitt, Suzanne, primary, George, Jason T., primary, Kreulen, R. Timothy, primary, Boss, Mary-Keara, primary, Lazarides, Alexander L., primary, Kerr, David L., primary, Gerber, Drew G., primary, Sivaraj, Dharshan, primary, Armstrong, Andrew J., primary, Dewhirst, Mark W., primary, Eward, William C., primary, Levine, Herbert, primary, and Somarelli, Jason A., primary

Published
2023
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34. Supplemental Figure 4 from Radioprotection of the Brain White Matter by Mn(III) N-Butoxyethylpyridylporphyrin–Based Superoxide Dismutase Mimic MnTnBuOE-2-PyP5+

Author

Weitzel, Douglas H., primary, Tovmasyan, Artak, primary, Ashcraft, Kathleen A., primary, Rajic, Zrinka, primary, Weitner, Tin, primary, Liu, Chunlei, primary, Li, Wei, primary, Buckley, Anne F., primary, Prasad, Mark R., primary, Young, Kenneth H., primary, Rodriguiz, Ramona M., primary, Wetsel, William C., primary, Peters, Katherine B., primary, Spasojevic, Ivan, primary, Herndon, James E., primary, Batinic-Haberle, Ines, primary, and Dewhirst, Mark W., primary

Published
2023
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35. Data from Effect of Low-Fat Diets on Plasma Levels of NF-κB–Regulated Inflammatory Cytokines and Angiogenic Factors in Men with Prostate Cancer

Author

Heymach, John V., primary, Shackleford, Terry J., primary, Tran, Hai T., primary, Yoo, Suk-Young, primary, Do, Kim-Anh, primary, Wergin, Melanie, primary, Saintigny, Pierre, primary, Vollmer, Robin T., primary, Polascik, Thomas J., primary, Snyder, Denise C., primary, Ruffin, Mack T., primary, Yan, Shaoyu, primary, Dewhirst, Mark, primary, Kunnumakkara, Ajaikumar B., primary, Aggarwal, Bharat B., primary, and Demark-Wahnefried, Wendy, primary

Published
2023
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36. Supplemental Figure 1 from Radioprotection of the Brain White Matter by Mn(III) N-Butoxyethylpyridylporphyrin–Based Superoxide Dismutase Mimic MnTnBuOE-2-PyP5+

Author

Weitzel, Douglas H., primary, Tovmasyan, Artak, primary, Ashcraft, Kathleen A., primary, Rajic, Zrinka, primary, Weitner, Tin, primary, Liu, Chunlei, primary, Li, Wei, primary, Buckley, Anne F., primary, Prasad, Mark R., primary, Young, Kenneth H., primary, Rodriguiz, Ramona M., primary, Wetsel, William C., primary, Peters, Katherine B., primary, Spasojevic, Ivan, primary, Herndon, James E., primary, Batinic-Haberle, Ines, primary, and Dewhirst, Mark W., primary

Published
2023
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37. Supplementary Tables 2-4 from Effect of Low-Fat Diets on Plasma Levels of NF-κB–Regulated Inflammatory Cytokines and Angiogenic Factors in Men with Prostate Cancer

Author

Heymach, John V., primary, Shackleford, Terry J., primary, Tran, Hai T., primary, Yoo, Suk-Young, primary, Do, Kim-Anh, primary, Wergin, Melanie, primary, Saintigny, Pierre, primary, Vollmer, Robin T., primary, Polascik, Thomas J., primary, Snyder, Denise C., primary, Ruffin, Mack T., primary, Yan, Shaoyu, primary, Dewhirst, Mark, primary, Kunnumakkara, Ajaikumar B., primary, Aggarwal, Bharat B., primary, and Demark-Wahnefried, Wendy, primary

Published
2023
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38. Supplementary Table 1 from Effect of Low-Fat Diets on Plasma Levels of NF-κB–Regulated Inflammatory Cytokines and Angiogenic Factors in Men with Prostate Cancer

Author

Heymach, John V., primary, Shackleford, Terry J., primary, Tran, Hai T., primary, Yoo, Suk-Young, primary, Do, Kim-Anh, primary, Wergin, Melanie, primary, Saintigny, Pierre, primary, Vollmer, Robin T., primary, Polascik, Thomas J., primary, Snyder, Denise C., primary, Ruffin, Mack T., primary, Yan, Shaoyu, primary, Dewhirst, Mark, primary, Kunnumakkara, Ajaikumar B., primary, Aggarwal, Bharat B., primary, and Demark-Wahnefried, Wendy, primary

Published
2023
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39. Supplemental Figure 3 from Radioprotection of the Brain White Matter by Mn(III) N-Butoxyethylpyridylporphyrin–Based Superoxide Dismutase Mimic MnTnBuOE-2-PyP5+

Author

Weitzel, Douglas H., primary, Tovmasyan, Artak, primary, Ashcraft, Kathleen A., primary, Rajic, Zrinka, primary, Weitner, Tin, primary, Liu, Chunlei, primary, Li, Wei, primary, Buckley, Anne F., primary, Prasad, Mark R., primary, Young, Kenneth H., primary, Rodriguiz, Ramona M., primary, Wetsel, William C., primary, Peters, Katherine B., primary, Spasojevic, Ivan, primary, Herndon, James E., primary, Batinic-Haberle, Ines, primary, and Dewhirst, Mark W., primary

Published
2023
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40. Supplementary Data from E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms

Author

Jolly, Mohit Kumar, primary, Ware, Kathryn E., primary, Xu, Shengnan, primary, Gilja, Shivee, primary, Shetler, Samantha, primary, Yang, Yanjun, primary, Wang, Xueyang, primary, Austin, R. Garland, primary, Runyambo, Daniella, primary, Hish, Alexander J., primary, Bartholf DeWitt, Suzanne, primary, George, Jason T., primary, Kreulen, R. Timothy, primary, Boss, Mary-Keara, primary, Lazarides, Alexander L., primary, Kerr, David L., primary, Gerber, Drew G., primary, Sivaraj, Dharshan, primary, Armstrong, Andrew J., primary, Dewhirst, Mark W., primary, Eward, William C., primary, Levine, Herbert, primary, and Somarelli, Jason A., primary

Published
2023
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41. Data from Comparison of Genomics and Functional Imaging from Canine Sarcomas Treated with Thermoradiotherapy Predicts Therapeutic Response and Identifies Combination Therapeutics

Author

Chi, Jen-Tsan, primary, Thrall, Donald E., primary, Jiang, Chen, primary, Snyder, Stacey, primary, Fels, Diane, primary, Landon, Chelsea, primary, McCall, Linda, primary, Lan, Lan, primary, Hauck, Marlene, primary, MacFall, James R., primary, Viglianti, Benjamin L., primary, and Dewhirst, Mark W., primary

Published
2023
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42. Supplementary Table S3 from Comparison of Genomics and Functional Imaging from Canine Sarcomas Treated with Thermoradiotherapy Predicts Therapeutic Response and Identifies Combination Therapeutics

Author

Chi, Jen-Tsan, primary, Thrall, Donald E., primary, Jiang, Chen, primary, Snyder, Stacey, primary, Fels, Diane, primary, Landon, Chelsea, primary, McCall, Linda, primary, Lan, Lan, primary, Hauck, Marlene, primary, MacFall, James R., primary, Viglianti, Benjamin L., primary, and Dewhirst, Mark W., primary

Published
2023
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44. Supplementary Figure 2 from Bevacizumab-Induced Alterations in Vascular Permeability and Drug Delivery: A Novel Approach to Augment Regional Chemotherapy for In-Transit Melanoma

Author

Turley, Ryan S., primary, Fontanella, Andrew N., primary, Padussis, James C., primary, Toshimitsu, Hiroaki, primary, Tokuhisa, Yoshihiro, primary, Cho, Eugenia H., primary, Hanna, Gabi, primary, Beasley, Georgia M., primary, Augustine, Christina K., primary, Dewhirst, Mark W., primary, and Tyler, Douglas S., primary

Published
2023
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45. Supplementary Figure 1 from Bevacizumab-Induced Alterations in Vascular Permeability and Drug Delivery: A Novel Approach to Augment Regional Chemotherapy for In-Transit Melanoma

Author

Turley, Ryan S., primary, Fontanella, Andrew N., primary, Padussis, James C., primary, Toshimitsu, Hiroaki, primary, Tokuhisa, Yoshihiro, primary, Cho, Eugenia H., primary, Hanna, Gabi, primary, Beasley, Georgia M., primary, Augustine, Christina K., primary, Dewhirst, Mark W., primary, and Tyler, Douglas S., primary

Published
2023
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46. Data from Bevacizumab-Induced Alterations in Vascular Permeability and Drug Delivery: A Novel Approach to Augment Regional Chemotherapy for In-Transit Melanoma

Author

Turley, Ryan S., primary, Fontanella, Andrew N., primary, Padussis, James C., primary, Toshimitsu, Hiroaki, primary, Tokuhisa, Yoshihiro, primary, Cho, Eugenia H., primary, Hanna, Gabi, primary, Beasley, Georgia M., primary, Augustine, Christina K., primary, Dewhirst, Mark W., primary, and Tyler, Douglas S., primary

Published
2023
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50. Supplementary Table 1 from Bevacizumab-Induced Alterations in Vascular Permeability and Drug Delivery: A Novel Approach to Augment Regional Chemotherapy for In-Transit Melanoma

Author

Turley, Ryan S., primary, Fontanella, Andrew N., primary, Padussis, James C., primary, Toshimitsu, Hiroaki, primary, Tokuhisa, Yoshihiro, primary, Cho, Eugenia H., primary, Hanna, Gabi, primary, Beasley, Georgia M., primary, Augustine, Christina K., primary, Dewhirst, Mark W., primary, and Tyler, Douglas S., primary

Published
2023
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