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336 results on '"Devynck, M A"'

47. Lack of Hypotensive Effect on Central Injection of Angiotensin Inhibitors in Spontaneously Hypertensive (SH) and Normotensive Rats

Author

Elghozi, J. L., Altman, J., Devynck, M. A., Liard, J. F., Grunfeld, J. P., and Meyer, P.

Abstract

1. Injections of antagonists of angiotensin II into the cerebral ventricles of normotensive and spontaneously hypertensive rats were performed in order to assess the role of the isorenin—angiotensin system in the brain. 2. No hypotensive effect was obtained in either normotensive or hypertensive rats, suggesting that intracranial isoangiotensin has little role in the pathogenesis of spontaneous hypertension in the rat.

Published
1976
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48. Alterations of Adrenal and Uterine Angiotensin II Receptors during Variation of Sodium Intake and/or Experimental Hypertension

Author

Devynck, M. A., Pernollet, M. G., MacDonald, G. J., Matthews, P. G., Raisman, R. S., and Meyer, P.

Abstract

1. Angiotensin II receptors from rat adrenal gland and myometrium were studied during variation of sodium intake. 2. In both target-tissues low Na+ diet increased the number of receptors whereas a high Na+ diet did not modify the adrenocortical receptors but increased the number of uterine receptors. 3. Deoxycorticosterone and one kidney Goldblatt hypertension were associated with a decrease in the number of adrenal receptors. 4. Alterations of angiotensin II receptors alone cannot explain satisfactorily the variations of sensitivity of target-cells to angiotensin II during sodium balance changes.

Published
1978
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50. Recent Advances on Endogenous Na+K+-ATPase Inhibitors: Clinical Investigation and Purification

Author

Cloix, J. F., Devynck, M. A., Wainer, I. W., Crabos, M., Pernollet, M. G., Deray, G., Rieu, M., and Meyer, P.

Abstract

Evidence exists which demonstrates the relationship between a Natriuretic Factor or Na+K+-ATPase inhibitor and volemic expansion, both in man and animal. Patients having extracellular volume expansion have been studied for the effect of their plasma on erythrocytes 3H-ouabain binding. High levels of ouabain-like activity was found in plasma from acromegalic patients and patients with chronic renal failure. High levels were also observed in some hypertensive patients. A partial purification of such a compound was performed from urine of hypertensives. The partially purified compound inhibited to a greater extent the Na+K+-ATPase semipurified from dog kidney than that from sheep brain. The present data are consistent with the possible regulation of the activity or the secretion of plasma ouabain-like activity by extracellular volume.

Published
1985
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