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1. Targeting Galectin 3 illuminates its contributions to the pathology of uterine serous carcinoma

Author

Matoba, Yusuke, Zarrella, Dominique T., Pooladanda, Venkatesh, Azimi Mohammadabadi, Maryam, Kim, Eugene, Kumar, Shaan, Xu, Mengyao, Qin, Xingping, Ray, Lauren J, Devins, Kyle M., Kumar, Raj, Kononenko, Artem, Eisenhauer, Eric, Veillard, Irva E., Yamagami, Wataru, Hill, Sarah J., Sarosiek, Kristopher A., Yeku, Oladapo O., Spriggs, David R., and Rueda, Bo R.

Published
2024
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7. Outcomes in ovarian Sertoli-Leydig cell tumor: A report from the International Pleuropulmonary Blastoma/DICER1 and Ovarian and Testicular Stromal Tumor Registries

Author

Nelson, Alexander T., Harris, Anne K., Watson, Dave, Kamihara, Junne, Chen, Kenneth S., Stall, Jennifer N., Devins, Kyle M., Young, Robert H., Olson, Damon R., Mallinger, Paige H.R., Mitchell, Sarah G., Hoffman, Lindsey M., Halliday, Gail, Suleymanova, Amina M., Glade Bender, Julia L., Messinger, Yoav H., Herzog, Cynthia E., Field, Amanda L., Frazier, A. Lindsay, Stewart, Douglas R., Dehner, Louis P., Hill, D. Ashley, Billmire, Deborah F., Schneider, Dominik T., and Schultz, Kris Ann P.

Published
2024
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8. Extensive versus focal lymphovascular invasion in squamous cell carcinoma of the cervix: A comprehensive international, multicenter, retrospective clinicopathologic study

Author

Praiss, Aaron M., Allison, Douglas, Tessier-Cloutier, Basile, Flynn, Jessica, Iasonos, Alexia, Hoang, Lien, Patrichi, Andrei, Terinte, Cristina, Pesci, Anna, Mateoiu, Claudia, Lastra, Ricardo R., Puscasiu, Lucian, Kiyokawa, Takako, Ali-Fehmi, Rouba, Kheil, Mira, Oliva, Esther, Devins, Kyle M., Abu-Rustum, Nadeem R., Soslow, Robert A., and Stolnicu, Simona

Published
2023
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9. Incidence and Clinicopathologic Characteristics of Human Papillomavirus–independent Invasive Squamous Cell Carcinomas of the Cervix: A Morphologic, Immunohistochemical, and Human Papilloma-Virologic Study of 670 Cases

Author

Stolnicu, Simona, Allison, Douglas, Praiss, Aaron M., Tessier-Cloutier, Basile, Momeni Boroujeni, Amir, Flynn, Jessica, Iasonos, Alexia, Serrette, Rene, Hoang, Lien, Patrichi, Andrei, Terinte, Cristina, Pesci, Anna, Mateoiu, Claudia, Lastra, Ricardo R., Kiyokawa, Takako, Ali-Fehmi, Rouba, Kheil, Mira, Oliva, Esther, Devins, Kyle M., Abu-Rustum, Nadeem R., and Soslow, Robert A.

Published
2023
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12. Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group

Author

Kanagal-Shamanna, Rashmi, Orazi, Attilio, Hasserjian, Robert P., Arber, Daniel A., Reichard, Kaaren, Hsi, Eric D., Bagg, Adam, Rogers, Heesun Joyce, Geyer, Julia, Darbaniyan, Faezeh, Do, Kim-Anh, Devins, Kyle M., Pozdnyakova, Olga, George, Tracy I., Cin, Paola Dal, Greipp, Patricia T., Routbort, Mark J., Patel, Keyur, Garcia-Manero, Guillermo, Verstovsek, Srdan, Medeiros, L. Jeffrey, Wang, Sa A., and Bueso-Ramos, Carlos

Published
2022
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15. Transitioning From Trainee to Practicing Pathologist: A Prospective Multi-institutional Survey of the Challenges Early Career Anatomic Pathologists Encounter When Entering Independent Practice.

Author

Katsakhyan, Levon, Devins, Kyle M., Jenkins, Taylor M., and Song, Sharon J.

Subjects
*SCALE analysis (Psychology), *PERSONNEL management, *SCHOLARSHIPS, *INTERNSHIP programs, *QUESTIONNAIRES, *DESCRIPTIVE statistics, *CONFIDENCE, *TRANSITIONAL programs (Education), *TIME management, *PSYCHOLOGY of medical students, *INTERPERSONAL relations, *VOCATIONAL guidance, *MEDICAL practice
Abstract

Context.--Pathology training programs generally prepare graduates well for the workforce, but there may be other aspects to navigating a job that make the transition from being a trainee to a practicing pathologist challenging. Objective.--To identify perceived challenges of independent practice for early career pathologists and assess how these impressions evolve throughout their first year. Design.--A survey was distributed to 12 anatomic pathology fellows from 4 institutions near the end of their final training year, and 6 months and 1 year after starting their first job. The surveys queried participants' comfort level with signing out cases independently and interacting with colleagues/trainees via Likert attitude scale questions, with free-text segments to elaborate on challenges experienced. Results.--The response rate to all 3 surveys was 100%. Confidence and comfort level with different aspects of independent sign-out increased incrementally over time. Main challenges encountered at 6 months included a high case load, signing out cases in areas outside of their subspecialty, time management, balancing teaching while signing out, laboratory issues, and developing relationships with clinicians. At 12 months, main challenges included time management, high case load, understaffing, laboratory issues, and signing out cases in areas outside of their subspecialty. Conclusions.--This study identified real-time challenges faced by those adjusting to their first year of independent practice. By gaining a better understanding of the factors that make this transition challenging, we can find tailored ways to support our early career pathologists. [ABSTRACT FROM AUTHOR]

Published
2024
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20. CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models

Author

Xu, Haineng, George, Erin, Kinose, Yasuto, Kim, Hyoung, Shah, Jennifer B., Peake, Jasmine D., Ferman, Benjamin, Medvedev, Sergey, Murtha, Thomas, Barger, Carter J., Devins, Kyle M., D’Andrea, Kurt, Wubbenhorst, Bradley, Schwartz, Lauren E., Hwang, Wei-Ting, Mills, Gordon B., Nathanson, Katherine L., Karpf, Adam R., Drapkin, Ronny, Brown, Eric J., and Simpkins, Fiona

Published
2021
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25. Proposal of Novel Binary Grading Systems for Cervical Squamous Cell Carcinoma

Author

Stolnicu, Simona, primary, Praiss, Aaron M., additional, Allison, Douglas, additional, Tessier-Cloutier, Basile, additional, Flynn, Jessica, additional, Iasonos, Alexia, additional, Hoang, Lien, additional, Terinte, Cristina, additional, Pesci, Anna, additional, Mateoiu, Claudia, additional, Lastra, Ricardo R., additional, Kiyokawa, Takako, additional, Ali-Fehmi, Rouba, additional, Kheil, Mira, additional, Oliva, Esther, additional, Devins, Kyle, additional, Abu-Rustum, Nadeem, additional, and Soslow, Robert A., additional

Published
2023
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26. Correction to: Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group

Author

Kanagal-Shamanna, Rashmi, Orazi, Attilio, Hasserjian, Robert P., Arber, Daniel A., Reichard, Kaaren, Hsi, Eric D., Bagg, Adam, Rogers, Heesun Joyce, Geyer, Julia, Darbaniyan, Faezeh, Do, Kim-Anh, Devins, Kyle M., Pozdnyakova, Olga, George, Tracy I., Cin, Paola Dal, Greipp, Patricia T., Routbort, Mark J., Patel, Keyur, Garcia-Manero, Guillermo, Verstovsek, Srdan, Medeiros, L. Jeffrey, Wang, Sa A., and Bueso-Ramos, Carlos

Published
2022
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29. H2Bub1 loss is an early contributor to clear cell ovarian cancer progression

Author

Ferrari, Adam J., primary, Rawat, Priyanka, additional, Rendulich, Hannah S., additional, Annapragada, Akshaya V., additional, Kinose, Yasuto, additional, Zhang, Xiaoming, additional, Devins, Kyle, additional, Budina, Anna, additional, Scharpf, Robert B., additional, Mitchell, Marilyn A., additional, Tanyi, Janos L., additional, Morgan, Mark A., additional, Schwartz, Lauren E., additional, Soong, T. Rinda, additional, Velculescu, Victor E., additional, and Drapkin, Ronny, additional

Published
2023
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31. Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models

Author

Kim, Hyoung, Xu, Haineng, George, Erin, Hallberg, Dorothy, Kumar, Sushil, Jagannathan, Veena, Medvedev, Sergey, Kinose, Yasuto, Devins, Kyle, Verma, Priyanka, Ly, Kevin, Wang, Yifan, Greenberg, Roger A., Schwartz, Lauren, Johnson, Neil, Scharpf, Robert B., Mills, Gordon B., Zhang, Rugang, Velculescu, Victor E., Brown, Eric J., and Simpkins, Fiona

Published
2020
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44. Sclerosing stromal tumour: a clinicopathological study of 100 cases of a distinctive benign ovarian stromal tumour typically occurring in the young.

Author

Devins, Kyle M., Young, Robert H., and Watkins, Jaclyn C.

Subjects
*LUTEIN, *TUMORS, *CLINICAL pathology, *FIBROMAS
Abstract

Aims: Since the sclerosing stromal tumour (SST) of the ovary was first described in 1973, few studies have expanded upon its histological features or overlap with other tumours. We thus investigate these aspects based on our experience with 100 cases. Methods and results: The patients, 14 of whom were pregnant, ranged from 12 to 63 years (median = 26 years). Ten patients had hormonal manifestations (seven oestrogenic, three androgenic). Bilateral ovarian involvement was present in two cases. Size ranged from 1 to 23 cm (mean = 8.4 cm). Most tumours were solid and white with focal yellow areas; oedema with cystic degeneration (seen in 25 cases) resulted in eight being predominantly cystic. On microscopic examination, alternating cellular and paucicellular areas (pseudolobulation) were prominent in 94 cases but seen to a limited degree in the remaining neoplasms. Admixed spindled and luteinised cells were present in all tumours, but 13 demonstrated mainly spindled cells and 19 demonstrated mainly lutein cells; 14 of the latter were from pregnant patients. The stroma was typically oedematous or collagenous, but in 14 cases was prominently hyalinised and, in four, myxoid. Prominent vascularity was present in most cases. The mitotic rate ranged from 0 to 8/10 high-power fields (HPF), but most demonstrated <1/10 HPF. Conclusions: The differential diagnosis of SST is broad, including fibromas, thecomas, solitary fibrous tumours, pregnancy luteomas, myxomas, other ovarian sex cord-stromal tumours with sclerosis and, rarely, Krukenberg tumours. Strict adherence to the requirement of pseudolobulation, prominent (usually ectatic) vessels, and lutein cells and fibroblasts admixed in a jumbled manner, will distinguish the neoplasm from others in the differential. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Chronic rhinosinusitis precipitated by tumor necrosis factor alpha inhibitors is the phenotype of chronic rhinosinusitis without nasal polyps

Author

Papagiannopoulos, Peter, primary, Devins, Kyle, additional, Tong, Charles Ching Lick, additional, Yver, Christina, additional, Patel, Neil N., additional, Kuhar, Hannah N., additional, Bosso, John V., additional, Kohanski, Michael A., additional, Tajudeen, Bobby A., additional, Kuan, Edward C., additional, Batra, Pete S., additional, Cohen, Noam A., additional, Kennedy, David W., additional, Palmer, James N., additional, Montone, Kathy, additional, and Adappa, Nithin D., additional

Published
2019
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48. Chronic rhinosinusitis precipitated by tumor necrosis factor alpha inhibitors is the phenotype of chronic rhinosinusitis without nasal polyps.

Author

Papagiannopoulos, Peter, Devins, Kyle, Tong, Charles Ching Lick, Yver, Christina, Patel, Neil N., Kuhar, Hannah N., Bosso, John V., Kohanski, Michael A., Tajudeen, Bobby A., Kuan, Edward C., Batra, Pete S., Cohen, Noam A., Kennedy, David W., Palmer, James N., Montone, Kathy, and Adappa, Nithin D.

Subjects
*TUMOR necrosis factors, *SINUSITIS, *ENDOSCOPIC surgery, *POLYPHOSPHATES
Abstract

Background: Chronic rhinosinusitis (CRS) is a frequently observed condition in patients with immunodeficiency secondary to tumor necrosis factor alpha inhibitors (TNFαis). The histologic features of CRS caused by TNFαis have yet to be determined and may have important implications in understanding the pathophysiology of the disease process. Methods: A structured histopathology report was used to analyze sinus tissue removed during functional endoscopic sinus surgery (FESS). These structured histopathology variables were compared among patients with CRS on TNFαi (CRSαi), CRS without nasal polyps (CRSsNP) patients, and CRS with nasal polyps (CRSwNP) patients. Results: Eighteen CRSαi, 91 CRSwNP, and 113 CRSsNP patients undergoing FESS were analyzed. Compared to CRSsNP, CRSαi patients exhibited increased mucosal ulceration (16.7% vs 0.9%, p < 0.008), increased fibrosis (100% vs 34.5%, p < 0.001), and increased presence of Charcot‐Leiden crystals (16.7% vs 0%, p < 0.002). Compared to CRSwNP, CRSαi patients demonstrated increased fibrosis (100% vs 54.9%, p < 0.001), decreased presence of subepithelial edema (44.4% vs 69.2% p < 0.043), decreased eosinophil aggregates (22.2% vs 47.3% p < 0.042), and fewer eosinophils per high‐power field (44.4% vs 73.6%, p < 0.017). Conclusion: CRSαi exhibits structured histopathology more similar to CRSsNP. In the appropriate clinical context, it may be reasonable that the medical regimen for these patients be focused on a more antineutrophilic, macrolide‐based approach. This study provides insight into the inflammatory environment of patients with CRSαi and may have implications for disease management. [ABSTRACT FROM AUTHOR]

Published
2020
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50. Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group

Author

Kanagal-Shamanna, Rashmi, Orazi, Attilio, Hasserjian, Robert P., Arber, Daniel A., Reichard, Kaaren, Hsi, Eric D., Bagg, Adam, Rogers, Heesun Joyce, Geyer, Julia, Darbaniyan, Faezeh, Do, Kim-Anh, Devins, Kyle M., Pozdnyakova, Olga, George, Tracy I., Cin, Paola Dal, Greipp, Patricia T., Routbort, Mark J., Patel, Keyur, Garcia-Manero, Guillermo, Verstovsek, Srdan, Medeiros, L. Jeffrey, Wang, Sa A., and Bueso-Ramos, Carlos

Abstract

Classification of myeloid neoplasms with isolated isochromosome i(17q) [17p deletion with inherent monoallelic TP53loss plus 17q duplication] is controversial. Most cases fall within the WHO unclassifiable myelodysplastic/myeloproliferative neoplasms (MDS/MPN-U) category. The uniformly dismal outcomes warrant better understanding of this entity. We undertook a multi-institutional retrospective study of 92 adult MDS/MPN-U cases from eight institutions. Twenty-nine (32%) patients had isolated i(17q) [MDS/MPN-i(17q)]. Compared to MDS/MPN without i(17q), MDS/MPN-i(17q) patients were significantly younger, had lower platelet and absolute neutrophil counts, and higher frequency of splenomegaly and circulating blasts. MDS/MPN-i(17q) cases showed frequent bilobed neutrophils (75% vs. 23%; P= 0.03), hypolobated megakaryocytes (62% vs. 20%; P= 0.06), and a higher frequency of SETBP1(69% vs. 5%; P= 0.002) and SRSF2(63% vs. 5%; P= 0.006) mutations that were frequently co-existent (44% vs. 0%; P= 0.01). TP53mutations were rare. The mutation profile of MDS/MPN-U-i(17q) was similar to other myeloid neoplasms with i(17q) including atypical chronic myeloid leukemia, chronic myelomonocytic leukemia, myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis, myelodysplastic syndrome and acute myeloid leukemia, with frequent concomitant SETBP1/SRSF2mutations observed across all the diagnostic entities. Over a median follow-up of 52 months, patients with MDS/MPN-i(17q) showed a shorter median overall survival (11 vs. 28 months; P< 0.001). The presence of i(17q) retained independent poor prognostic value in multivariable Cox-regression analysis [HR 3.686 (1.17–11.6); P= 0.026] along with splenomegaly. We suggest that MDS/MPN-i(17q) warrants recognition as a distinct subtype within the MDS/MPN-U category based on its unique clinico-biologic features and uniformly poor prognosis.

Published
2021
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