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4. Data from Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma

Author

Dong, Lei, primary, You, Shuo, primary, Zhang, Qing, primary, Osuka, Satoru, primary, Devi, Narra S., primary, Kaluz, Stefan, primary, Ferguson, Jalisa H., primary, Yang, Hua, primary, Chen, Guoliang, primary, Wang, Binghe, primary, Grossniklaus, Hans E., primary, and Van Meir, Erwin G., primary

Published
2023
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5. Supplemental Tables 2-6 from Selective Detection of the D-enantiomer of 2-Hydroxyglutarate in the CSF of Glioma Patients with Mutated Isocitrate Dehydrogenase

Author

Kalinina, Juliya, primary, Ahn, Jun, primary, Devi, Narra S., primary, Wang, Liya, primary, Li, Yuancheng, primary, Olson, Jeffrey J., primary, Glantz, Michael, primary, Smith, Thomas, primary, Kim, Ella L., primary, Giese, Alf, primary, Jensen, Randy L., primary, Chen, Clark C., primary, Carter, Bob S., primary, Mao, Hui, primary, He, Miao, primary, and Van Meir, Erwin G., primary

Published
2023
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6. Suppl. Fig. Legends from Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma

Author

Dong, Lei, primary, You, Shuo, primary, Zhang, Qing, primary, Osuka, Satoru, primary, Devi, Narra S., primary, Kaluz, Stefan, primary, Ferguson, Jalisa H., primary, Yang, Hua, primary, Chen, Guoliang, primary, Wang, Binghe, primary, Grossniklaus, Hans E., primary, and Van Meir, Erwin G., primary

Published
2023
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7. Supplementary Information from A Chimeric Signal Peptide–Galectin-3 Conjugate Induces Glycosylation-Dependent Cancer Cell–Specific Apoptosis

Author

Lee, Sok-Hyong, primary, Khwaja Rehman, Fatima, primary, Tyler, Kari C., primary, Yu, Bing, primary, Zhang, Zhaobin, primary, Osuka, Satoru, primary, Zerrouqi, Abdessamad, primary, Kaluzova, Milota, primary, Hadjipanayis, Costas G., primary, Cummings, Richard D., primary, Olson, Jeffrey J., primary, Devi, Narra S., primary, and Van Meir, Erwin G., primary

Published
2023
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8. Supplementary Figure Legend from Arylsulfonamide KCN1 Inhibits In Vivo Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP

Author

Yin, Shaoman, primary, Kaluz, Stefan, primary, Devi, Narra S., primary, Jabbar, Adnan A., primary, de Noronha, Rita G., primary, Mun, Jiyoung, primary, Zhang, Zhaobin, primary, Boreddy, Purushotham R., primary, Wang, Wei, primary, Wang, Zhibo, primary, Abbruscato, Thomas, primary, Chen, Zhengjia, primary, Olson, Jeffrey J., primary, Zhang, Ruiwen, primary, Goodman, Mark M., primary, Nicolaou, K.C., primary, and Van Meir, Erwin G., primary

Published
2023
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9. Suppl. Table 1 from Selective Detection of the D-enantiomer of 2-Hydroxyglutarate in the CSF of Glioma Patients with Mutated Isocitrate Dehydrogenase

Author

Kalinina, Juliya, primary, Ahn, Jun, primary, Devi, Narra S., primary, Wang, Liya, primary, Li, Yuancheng, primary, Olson, Jeffrey J., primary, Glantz, Michael, primary, Smith, Thomas, primary, Kim, Ella L., primary, Giese, Alf, primary, Jensen, Randy L., primary, Chen, Clark C., primary, Carter, Bob S., primary, Mao, Hui, primary, He, Miao, primary, and Van Meir, Erwin G., primary

Published
2023
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10. Supplementary Data from Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma

Author

Dong, Lei, primary, You, Shuo, primary, Zhang, Qing, primary, Osuka, Satoru, primary, Devi, Narra S., primary, Kaluz, Stefan, primary, Ferguson, Jalisa H., primary, Yang, Hua, primary, Chen, Guoliang, primary, Wang, Binghe, primary, Grossniklaus, Hans E., primary, and Van Meir, Erwin G., primary

Published
2023
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11. supplemental figures from Selective Detection of the D-enantiomer of 2-Hydroxyglutarate in the CSF of Glioma Patients with Mutated Isocitrate Dehydrogenase

Author

Kalinina, Juliya, primary, Ahn, Jun, primary, Devi, Narra S., primary, Wang, Liya, primary, Li, Yuancheng, primary, Olson, Jeffrey J., primary, Glantz, Michael, primary, Smith, Thomas, primary, Kim, Ella L., primary, Giese, Alf, primary, Jensen, Randy L., primary, Chen, Clark C., primary, Carter, Bob S., primary, Mao, Hui, primary, He, Miao, primary, and Van Meir, Erwin G., primary

Published
2023
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12. Supplementary Methods from Arylsulfonamide KCN1 Inhibits In Vivo Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP

Author

Yin, Shaoman, primary, Kaluz, Stefan, primary, Devi, Narra S., primary, Jabbar, Adnan A., primary, de Noronha, Rita G., primary, Mun, Jiyoung, primary, Zhang, Zhaobin, primary, Boreddy, Purushotham R., primary, Wang, Wei, primary, Wang, Zhibo, primary, Abbruscato, Thomas, primary, Chen, Zhengjia, primary, Olson, Jeffrey J., primary, Zhang, Ruiwen, primary, Goodman, Mark M., primary, Nicolaou, K.C., primary, and Van Meir, Erwin G., primary

Published
2023
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13. Supplementary Figures S1-S6 from Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma

Author

Dong, Lei, primary, You, Shuo, primary, Zhang, Qing, primary, Osuka, Satoru, primary, Devi, Narra S., primary, Kaluz, Stefan, primary, Ferguson, Jalisa H., primary, Yang, Hua, primary, Chen, Guoliang, primary, Wang, Binghe, primary, Grossniklaus, Hans E., primary, and Van Meir, Erwin G., primary

Published
2023
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14. Supplementary Figures 4 - 8 from Arylsulfonamide KCN1 Inhibits In Vivo Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP

Author

Yin, Shaoman, primary, Kaluz, Stefan, primary, Devi, Narra S., primary, Jabbar, Adnan A., primary, de Noronha, Rita G., primary, Mun, Jiyoung, primary, Zhang, Zhaobin, primary, Boreddy, Purushotham R., primary, Wang, Wei, primary, Wang, Zhibo, primary, Abbruscato, Thomas, primary, Chen, Zhengjia, primary, Olson, Jeffrey J., primary, Zhang, Ruiwen, primary, Goodman, Mark M., primary, Nicolaou, K.C., primary, and Van Meir, Erwin G., primary

Published
2023
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15. Supplementary Figures 1 - 3 from Arylsulfonamide KCN1 Inhibits In Vivo Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP

Author

Yin, Shaoman, primary, Kaluz, Stefan, primary, Devi, Narra S., primary, Jabbar, Adnan A., primary, de Noronha, Rita G., primary, Mun, Jiyoung, primary, Zhang, Zhaobin, primary, Boreddy, Purushotham R., primary, Wang, Wei, primary, Wang, Zhibo, primary, Abbruscato, Thomas, primary, Chen, Zhengjia, primary, Olson, Jeffrey J., primary, Zhang, Ruiwen, primary, Goodman, Mark M., primary, Nicolaou, K.C., primary, and Van Meir, Erwin G., primary

Published
2023
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16. Figures S1-S7 from A Chimeric Signal Peptide–Galectin-3 Conjugate Induces Glycosylation-Dependent Cancer Cell–Specific Apoptosis

Author

Lee, Sok-Hyong, primary, Khwaja Rehman, Fatima, primary, Tyler, Kari C., primary, Yu, Bing, primary, Zhang, Zhaobin, primary, Osuka, Satoru, primary, Zerrouqi, Abdessamad, primary, Kaluzova, Milota, primary, Hadjipanayis, Costas G., primary, Cummings, Richard D., primary, Olson, Jeffrey J., primary, Devi, Narra S., primary, and Van Meir, Erwin G., primary

Published
2023
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17. Data from Vasculostatin Inhibits Intracranial Glioma Growth and Negatively Regulates In vivo Angiogenesis through a CD36-Dependent Mechanism

Author

Kaur, Balveen, primary, Cork, Sarah M., primary, Sandberg, Eric M., primary, Devi, Narra S., primary, Zhang, Zhaobin, primary, Klenotic, Philip A., primary, Febbraio, Maria, primary, Shim, Hyunsuk, primary, Mao, Hui, primary, Tucker-Burden, Carol, primary, Silverstein, Roy L., primary, Brat, Daniel J., primary, Olson, Jeffrey J., primary, and Van Meir, Erwin G., primary

Published
2023
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18. Supplementary Figure 1 from Vasculostatin Inhibits Intracranial Glioma Growth and Negatively Regulates In vivo Angiogenesis through a CD36-Dependent Mechanism

Author

Kaur, Balveen, primary, Cork, Sarah M., primary, Sandberg, Eric M., primary, Devi, Narra S., primary, Zhang, Zhaobin, primary, Klenotic, Philip A., primary, Febbraio, Maria, primary, Shim, Hyunsuk, primary, Mao, Hui, primary, Tucker-Burden, Carol, primary, Silverstein, Roy L., primary, Brat, Daniel J., primary, Olson, Jeffrey J., primary, and Van Meir, Erwin G., primary

Published
2023
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19. Supplementary Figure Legends 1-2 from Vasculostatin Inhibits Intracranial Glioma Growth and Negatively Regulates In vivo Angiogenesis through a CD36-Dependent Mechanism

Author

Kaur, Balveen, primary, Cork, Sarah M., primary, Sandberg, Eric M., primary, Devi, Narra S., primary, Zhang, Zhaobin, primary, Klenotic, Philip A., primary, Febbraio, Maria, primary, Shim, Hyunsuk, primary, Mao, Hui, primary, Tucker-Burden, Carol, primary, Silverstein, Roy L., primary, Brat, Daniel J., primary, Olson, Jeffrey J., primary, and Van Meir, Erwin G., primary

Published
2023
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20. Supplementary Note from Vasculostatin Inhibits Intracranial Glioma Growth and Negatively Regulates In vivo Angiogenesis through a CD36-Dependent Mechanism

Author

Kaur, Balveen, primary, Cork, Sarah M., primary, Sandberg, Eric M., primary, Devi, Narra S., primary, Zhang, Zhaobin, primary, Klenotic, Philip A., primary, Febbraio, Maria, primary, Shim, Hyunsuk, primary, Mao, Hui, primary, Tucker-Burden, Carol, primary, Silverstein, Roy L., primary, Brat, Daniel J., primary, Olson, Jeffrey J., primary, and Van Meir, Erwin G., primary

Published
2023
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21. Supplementary Figure 2 from Vasculostatin Inhibits Intracranial Glioma Growth and Negatively Regulates In vivo Angiogenesis through a CD36-Dependent Mechanism

Author

Kaur, Balveen, primary, Cork, Sarah M., primary, Sandberg, Eric M., primary, Devi, Narra S., primary, Zhang, Zhaobin, primary, Klenotic, Philip A., primary, Febbraio, Maria, primary, Shim, Hyunsuk, primary, Mao, Hui, primary, Tucker-Burden, Carol, primary, Silverstein, Roy L., primary, Brat, Daniel J., primary, Olson, Jeffrey J., primary, and Van Meir, Erwin G., primary

Published
2023
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23. EZH2 targeting in medulloblastoma reduces tumor growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway

Author

Zhang, Hanwen, Zhu, Dan, Zhang, Zhaobin, Kaluz, Stefan, Yu, Bing, Devi, Narra S., Olson, Jeffrey J., and Van Meir, Erwin G.

Subjects
BAI1, ADGRB1, C/EBPβ, macromolecular substances, TP53, EZH2, adhesion GPCR, CBP, medulloblastoma, Article
Abstract

Medulloblastoma is a malignant pediatric tumor for which new therapies are urgently needed. We demonstrate that treatment with EPZ-6438 (Tazemetostat), an enhancer of zeste homologue 2 (EZH2) inhibitor approved for clinical trials, blocks MB cell growth in vitro and in vivo, and prolongs survival in orthotopic xenograft models. We show that the therapeutic effect is dependent on epigenetic reactivation of adhesion G protein-coupled receptor B1 (ADGRB1), a tumor suppressor gene that controls p53 stability by blocking Mdm2. Histone 3 trimethylated on lysine 27 (H3K27me3), a marker of silent chromatin conformation is present at the ADGRB1 promoter, and inhibition of EZH2, the catalytic component of the Polycomb Repressive complex 2 (PRC2) that methylates H3K27, switches the gene into an active chromatin status and reactivates BAI1 expression. Mechanistically, targeting EZH2 promotes transition from H3K27me3 to H3K27ac at the promoter, recruits the C/EBPβ (CREB-binding protein) and CBP transcription factors and activates ADGRB1 transcription. Taken together, our results identified key molecular players that regulate ADGRB1 gene expression in MB, demonstrate that reactivation of BAI1 expression underlies EPZ-6438 anti-tumorigenic action, and provide pre-clinical proof-of-principle evidence for targeting EZH2 in patients with MB.

Published
2019

25. A Chimeric Signal Peptide–Galectin-3 Conjugate Induces Glycosylation-Dependent Cancer Cell–Specific Apoptosis

Author

Lee, Sok-Hyong, primary, Khwaja Rehman, Fatima, additional, Tyler, Kari C., additional, Yu, Bing, additional, Zhang, Zhaobin, additional, Osuka, Satoru, additional, Zerrouqi, Abdessamad, additional, Kaluzova, Milota, additional, Hadjipanayis, Costas G., additional, Cummings, Richard D., additional, Olson, Jeffrey J., additional, Devi, Narra S., additional, and Van Meir, Erwin G., additional

Published
2020
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30. Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma

Author

Dong, Lei, primary, You, Shuo, additional, Zhang, Qing, additional, Osuka, Satoru, additional, Devi, Narra S., additional, Kaluz, Stefan, additional, Ferguson, Jalisa H., additional, Yang, Hua, additional, Chen, Guoliang, additional, Wang, Binghe, additional, Grossniklaus, Hans E., additional, and Van Meir, Erwin G., additional

Published
2019
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31. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation

Author

Zhu, Dan, primary, Osuka, Satoru, additional, Zhang, Zhaobin, additional, Reichert, Zachery R., additional, Yang, Liquan, additional, Kanemura, Yonehiro, additional, Jiang, Ying, additional, You, Shuo, additional, Zhang, Hanwen, additional, Devi, Narra S., additional, Bhattacharya, Debanjan, additional, Takano, Shingo, additional, Gillespie, G. Yancey, additional, Macdonald, Tobey, additional, Tan, Chalet, additional, Nishikawa, Ryo, additional, Nelson, William G., additional, Olson, Jeffrey J., additional, and Van Meir, Erwin G., additional

Published
2018
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32. Selective Detection of the D-enantiomer of 2-Hydroxyglutarate in the CSF of Glioma Patients with Mutated Isocitrate Dehydrogenase

Author

Kalinina, Juliya, primary, Ahn, Jun, additional, Devi, Narra S., additional, Wang, Liya, additional, Li, Yuancheng, additional, Olson, Jeffrey J., additional, Glantz, Michael, additional, Smith, Thomas, additional, Kim, Ella L., additional, Giese, Alf, additional, Jensen, Randy L., additional, Chen, Clark C., additional, Carter, Bob S., additional, Mao, Hui, additional, He, Miao, additional, and Van Meir, Erwin G., additional

Published
2016
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34. The Somatic Genomic Landscape of Glioblastoma

Author

Brennan, Cameron W., primary, Verhaak, Roel G.W., additional, McKenna, Aaron, additional, Campos, Benito, additional, Noushmehr, Houtan, additional, Salama, Sofie R., additional, Zheng, Siyuan, additional, Chakravarty, Debyani, additional, Sanborn, J. Zachary, additional, Berman, Samuel H., additional, Beroukhim, Rameen, additional, Bernard, Brady, additional, Wu, Chang-Jiun, additional, Genovese, Giannicola, additional, Shmulevich, Ilya, additional, Barnholtz-Sloan, Jill, additional, Zou, Lihua, additional, Vegesna, Rahulsimham, additional, Shukla, Sachet A., additional, Ciriello, Giovanni, additional, Yung, W.K., additional, Zhang, Wei, additional, Sougnez, Carrie, additional, Mikkelsen, Tom, additional, Aldape, Kenneth, additional, Bigner, Darell D., additional, Van Meir, Erwin G., additional, Prados, Michael, additional, Sloan, Andrew, additional, Black, Keith L., additional, Eschbacher, Jennifer, additional, Finocchiaro, Gaetano, additional, Friedman, William, additional, Andrews, David W., additional, Guha, Abhijit, additional, Iacocca, Mary, additional, O’Neill, Brian P., additional, Foltz, Greg, additional, Myers, Jerome, additional, Weisenberger, Daniel J., additional, Penny, Robert, additional, Kucherlapati, Raju, additional, Perou, Charles M., additional, Hayes, D. Neil, additional, Gibbs, Richard, additional, Marra, Marco, additional, Mills, Gordon B., additional, Lander, Eric, additional, Spellman, Paul, additional, Wilson, Richard, additional, Sander, Chris, additional, Weinstein, John, additional, Meyerson, Matthew, additional, Gabriel, Stacey, additional, Laird, Peter W., additional, Haussler, David, additional, Getz, Gad, additional, Chin, Lynda, additional, Benz, Christopher, additional, Barrett, Wendi, additional, Ostrom, Quinn, additional, Wolinsky, Yingli, additional, Bose, Bikash, additional, Boulos, Paul T., additional, Boulos, Madgy, additional, Brown, Jenn, additional, Czerinski, Christine, additional, Eppley, Matthew, additional, Kempista, Thelma, additional, Kitko, Teresa, additional, Koyfman, Yakov, additional, Rabeno, Brenda, additional, Rastogi, Pawan, additional, Sugarman, Michael, additional, Swanson, Patricia, additional, Yalamanchii, Kennedy, additional, Otey, Ilana P., additional, Liu, Yingchun Spring, additional, Xiao, Yonghong, additional, Auman, J.Todd, additional, Chen, Peng-Chieh, additional, Hadjipanayis, Angela, additional, Lee, Eunjung, additional, Lee, Semin, additional, Park, Peter J., additional, Seidman, Jonathan, additional, Yang, Lixing, additional, Kalkanis, Steven, additional, Poisson, Laila M., additional, Raghunathan, Aditya, additional, Scarpace, Lisa, additional, Bressler, Ryan, additional, Eakin, Andrea, additional, Iype, Lisa, additional, Kreisberg, Richard B., additional, Leinonen, Kalle, additional, Reynolds, Sheila, additional, Rovira, Hector, additional, Thorsson, Vesteinn, additional, Annala, Matti J., additional, Paulauskis, Joseph, additional, Curley, Erin, additional, Hatfield, Martha, additional, Mallery, David, additional, Morris, Scott, additional, Shelton, Troy, additional, Shelton, Candace, additional, Sherman, Mark, additional, Yena, Peggy, additional, Cuppini, Lucia, additional, DiMeco, Francesco, additional, Eoli, Marica, additional, Maderna, Emanuela, additional, Pollo, Bianca, additional, Saini, Marco, additional, Balu, Saianand, additional, Hoadley, Katherine A., additional, Li, Ling, additional, Miller, C. Ryan, additional, Shi, Yan, additional, Topal, Michael D., additional, Wu, Junyuan, additional, Dunn, Gavin, additional, Giannini, Caterina, additional, O'Neill, Brian P., additional, Aksoy, B. Arman, additional, Antipin, Yevgeniy, additional, Borsu, Laetitia, additional, Brennan, Cameron W., additional, Cerami, Ethan, additional, Gao, Jianjiong, additional, Gross, Benjamin, additional, Jacobsen, Anders, additional, Ladanyi, Marc, additional, Lash, Alex, additional, Liang, Yupu, additional, Reva, Boris, additional, Schultz, Nikolaus, additional, Shen, Ronglai, additional, Socci, Nicholas D., additional, Viale, Agnes, additional, Ferguson, Martin L., additional, Chen, Qing-Rong, additional, Demchok, John A., additional, Dillon, Laura A.L., additional, Shaw, Kenna R. Mills, additional, Sheth, Margi, additional, Tarnuzzer, Roy, additional, Wang, Zhining, additional, Yang, Liming, additional, Davidsen, Tanja, additional, Guyer, Mark S., additional, Ozenberger, Bradley A., additional, Sofia, Heidi J., additional, Bergsten, Julie, additional, Eckman, John, additional, Harr, Jodi, additional, Smith, Christine, additional, Tucker, Kelly, additional, Winemiller, Cindy, additional, Zach, Leigh Anne, additional, Ljubimova, Julia Y., additional, Eley, Greg, additional, Ayala, Brenda, additional, Jensen, Mark A., additional, Kahn, Ari, additional, Pihl, Todd D., additional, Pot, David A., additional, Wan, Yunhu, additional, Hansen, Nathan, additional, Hothi, Parvi, additional, Lin, Biaoyang, additional, Shah, Nameeta, additional, Yoon, Jae-geun, additional, Lau, Ching, additional, Berens, Michael, additional, Ardlie, Kristin, additional, Carter, Scott L., additional, Cherniack, Andrew D., additional, Noble, Mike, additional, Cho, Juok, additional, Cibulskis, Kristian, additional, DiCara, Daniel, additional, Frazer, Scott, additional, Gabriel, Stacey B., additional, Gehlenborg, Nils, additional, Gentry, Jeff, additional, Heiman, David, additional, Kim, Jaegil, additional, Jing, Rui, additional, Lander, Eric S., additional, Lawrence, Michael, additional, Lin, Pei, additional, Mallard, Will, additional, Onofrio, Robert C., additional, Saksena, Gordon, additional, Schumacher, Steve, additional, Stojanov, Petar, additional, Tabak, Barbara, additional, Voet, Doug, additional, Zhang, Hailei, additional, Dees, Nathan N., additional, Ding, Li, additional, Fulton, Lucinda L., additional, Fulton, Robert S., additional, Kanchi, Krishna-Latha, additional, Mardis, Elaine R., additional, Wilson, Richard K., additional, Baylin, Stephen B., additional, Harshyne, Larry, additional, Cohen, Mark L., additional, Devine, Karen, additional, Sloan, Andrew E., additional, VandenBerg, Scott R., additional, Berger, Mitchel S., additional, Carlin, Daniel, additional, Craft, Brian, additional, Ellrott, Kyle, additional, Goldman, Mary, additional, Goldstein, Theodore, additional, Grifford, Mia, additional, Ma, Singer, additional, Ng, Sam, additional, Stuart, Joshua, additional, Swatloski, Teresa, additional, Waltman, Peter, additional, Zhu, Jing, additional, Foss, Robin, additional, Frentzen, Barbara, additional, McTiernan, Raquel, additional, Yachnis, Anthony, additional, Mao, Yong, additional, Akbani, Rehan, additional, Bogler, Oliver, additional, Fuller, Gregory N., additional, Liu, Wenbin, additional, Liu, Yuexin, additional, Lu, Yiling, additional, Mills, Gordon, additional, Protopopov, Alexei, additional, Ren, Xiaojia, additional, Sun, Youting, additional, Yung, W.K. Alfred, additional, Zhang, Jianhua, additional, Chen, Ken, additional, Weinstein, John N., additional, Bootwalla, Moiz S., additional, Lai, Phillip H., additional, Triche, Timothy J., additional, Van Den Berg, David J., additional, Gutmann, David H., additional, Lehman, Norman L., additional, VanMeir, Erwin G., additional, Brat, Daniel, additional, Olson, Jeffrey J., additional, Mastrogianakis, Gena M., additional, Devi, Narra S., additional, Zhang, Zhaobin, additional, Bigner, Darell, additional, Lipp, Eric, additional, and McLendon, Roger, additional

Published
2013
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35. Arylsulfonamide KCN1 Inhibits In Vivo Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP

Author

Yin, Shaoman, primary, Kaluz, Stefan, additional, Devi, Narra S., additional, Jabbar, Adnan A., additional, de Noronha, Rita G., additional, Mun, Jiyoung, additional, Zhang, Zhaobin, additional, Boreddy, Purushotham R., additional, Wang, Wei, additional, Wang, Zhibo, additional, Abbruscato, Thomas, additional, Chen, Zhengjia, additional, Olson, Jeffrey J., additional, Zhang, Ruiwen, additional, Goodman, Mark M., additional, Nicolaou, K.C., additional, and Van Meir, Erwin G., additional

Published
2012
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37. Vasculostatin Inhibits Intracranial Glioma Growth and Negatively RegulatesIn vivoAngiogenesis through a CD36-Dependent Mechanism

Author

Kaur, Balveen, primary, Cork, Sarah M., additional, Sandberg, Eric M., additional, Devi, Narra S., additional, Zhang, Zhaobin, additional, Klenotic, Philip A., additional, Febbraio, Maria, additional, Shim, Hyunsuk, additional, Mao, Hui, additional, Tucker-Burden, Carol, additional, Silverstein, Roy L., additional, Brat, Daniel J., additional, Olson, Jeffrey J., additional, and Van Meir, Erwin G., additional

Published
2009
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40. Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism.

Author

Kaur B, Cork SM, Sandberg EM, Devi NS, Zhang Z, Klenotic PA, Febbraio M, Shim H, Mao H, Tucker-Burden C, Silverstein RL, Brat DJ, Olson JJ, and Van Meir EG

Subjects
Angiogenic Proteins genetics, Angiogenic Proteins metabolism, Animals, Brain Neoplasms genetics, Cell Line, Tumor, Cell Movement physiology, Corneal Neovascularization drug therapy, DNA, Complementary administration & dosage, DNA, Complementary genetics, Endothelial Cells pathology, Glioblastoma genetics, Humans, Mice, Mice, Nude, Neovascularization, Pathologic metabolism, Neovascularization, Pathologic therapy, Peptide Fragments genetics, Peptide Fragments metabolism, Rats, Receptors, G-Protein-Coupled, Transfection, Xenograft Model Antitumor Assays, Angiogenic Proteins biosynthesis, Brain Neoplasms blood supply, Brain Neoplasms therapy, CD36 Antigens metabolism, Glioblastoma blood supply, Glioblastoma therapy, Peptide Fragments biosynthesis
Abstract

Angiogenesis is a critical physiologic process that is appropriated during tumorigenesis. Little is known about how this process is specifically regulated in the brain. Brain angiogenesis inhibitor-1 (BAI1) is a brain-predominant seven-transmembrane protein that contains five antiangiogenic thrombospondin type-1 repeats (TSR). We recently showed that BAI1 is cleaved at a conserved proteolytic cleavage site releasing a soluble, 120 kDa antiangiogenic factor called vasculostatin (Vstat120). Vstat120 has been shown to inhibit in vitro angiogenesis and suppress subcutaneous tumor growth. Here, we examine its effect on the intracranial growth of malignant gliomas and further study its antitumor mechanism. First, we show that expression of Vstat120 strongly suppresses the intracranial growth of malignant gliomas, even in the presence of the strong proangiogenic stimulus mediated by the oncoprotein epidermal growth factor receptor variant III (EGFRvIII). This tumor-suppressive effect is accompanied by a decrease in tumor vascular density, suggesting a potent antiangiogenic effect in the brain. Second, and consistent with this interpretation, we find that treatment with Vstat120 reduces the migration of cultured microvascular endothelial cells in vitro and inhibits corneal angiogenesis in vivo. Third, we show that these antivascular effects critically depend on the presence of the cell surface receptor CD36 on endothelial cells in vitro and in vivo, supporting the role of Vstat120 TSRs in mediating these effects. These results advance the understanding of brain-specific angiogenic regulation, and suggest that Vstat120 has therapeutic potential in the treatment of brain tumors and other intracerebral vasculopathies.

Published
2009
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