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Particularizando el debate en la Seguridad Social española y sus prestaciones de muerte y supervivencia, el artículo revisa la posibilidad de una transición desde corrientes de pagos vitalicias hacia estructuras temporales dentro de estas coberturas. Se presenta el planteamiento teórico y se exponen los resultados prácticos de acuerdo a la Muestra Continua de Vidas Laborales (datos reales de prestaciones) y a la aplicación de la equivalencia actuarial, con un análisis de sensibilidad en las principales hipótesis del modelo. Como intuitivamente es de esperar, la transición desde prestaciones vitalicias a temporales conlleva una reducción de costes iniciales por generación para el sistema público de protección y una mayor equidad en la relación entre aportaciones y prestaciones, si bien este hecho también debe observarse desde otras perspectivas, entre ellas la del posible beneficiario que vería reducidas sus expectativas globales de beneficios. Por otra parte, se presenta una alternativa de transformación de la corriente de prestaciones en varios períodos y diferentes cuantías en los mismos, opción que favorece una mayor protección en las cercanías del hecho causante. || This article explores the possibility of transition from lifetime benefits to temporary payments, specifying the debate in the Spanish Social Security. The theoretical approach is presented and, according to the Continuous Sample of Working Lives, the application of actuarial equivalence and a sensitivity analysis on the main hypothesis, practical results are calculated. As it would be intuitively expected, the transition from lifetime benefits to temporary payments leads to better fairness in the model and a cost reduction in the initial expenses per generation for public protection system, although other perspectives, including reduced expectations for potential beneficiaries, should be also seen. Furthermore, the possibility of using different periods and amounts in the structure of expenses is shown as well. This option improves the protection at the time closest to the fact that generates the benefit.

Mass-tolerant open search methods allow the high-throughput analysis of modified peptides by mass spectrometry. These techniques have paved the way to unbiased analysis of post-translational modifications in biological contexts, as well as of chemical modifications produced during the manipulation of protein samples. In this work, we have analyzed in-depth a wide variety of samples of different biological origin, including cells, extracellular vesicles, secretomes, centrosomes and tissue preparations, using Comet-ReCom, a recently improved version of the open search engine Comet-PTM. Our results demonstrate that glutamic acid residues undergo intensive methyl esterification when protein digestion is performed using in-gel techniques, but not using gel-free approaches. This effect was highly specific to Glu and was not found for other methylable residues such as Asp., Competing Interests: Declaration of competing interest The authors declare no competing interests., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Many bioinformatics tools are available for the quantitative analysis of proteomics experiments. Most of these tools use a dedicated statistical model to derive absolute quantitative protein values from mass spectrometry (MS) data. Here, we present iSanXoT, a standalone application that processes relative abundances between MS signals and then integrates them sequentially to upper levels using the previously published Generic Integration Algorithm (GIA). iSanXoT offers unique capabilities that complement conventional quantitative software applications, including statistical weighting and independent modeling of error distributions in each integration, aggregation of technical or biological replicates, quantification of posttranslational modifications, and analysis of coordinated protein behavior. iSanXoT is a standalone, user-friendly application that accepts output from popular proteomics pipelines and enables unrestricted creation of quantification workflows and fully customizable reports that can be reused across projects or shared among users. Numerous publications attest the successful application of diverse integrative workflows constructed using the GIA for the analysis of high-throughput quantitative proteomics experiments. iSanXoT has been tested with the main operating systems. Download links for the corresponding distributions are available at https://github.com/CNIC-Proteomics/iSanXoT/releases., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could influence the work reported in this paper., (© 2024 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.)