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8 results on '"Deuster, J. E."'

5. [Effects of amantadine on heart and circulation].

Author

van Ackern K, Deuster JE, Mast GJ, and Schmier J

Subjects
Amantadine adverse effects, Animals, Blood Pressure drug effects, Cardiac Complexes, Premature chemically induced, Cardiac Output drug effects, Depression, Chemical, Dogs, Female, Heart Rate drug effects, Male, Myocardial Contraction drug effects, Stimulation, Chemical, Vascular Resistance drug effects, Amantadine pharmacology, Heart drug effects, Hemodynamics drug effects
Abstract

The effect of amantadine-hydrochloride on heart and circulation is studied in 7 anesthetized, otherwise normal dogs with a mean body weight of 27.2 kg and in 8 heart-lung preparations of dogs. Arterial blood pressure, right atrial pressure, cardiac output and heart rate are measured and continuously monitored. Stroke volume and peripheral resistance are calculated. Left ventricular peak- and enddiastolic pressure, the rate of rise of intraventricular pressure and t-dp/dt are additionally measured in the heart-lung-preparations. Below 3 mg with kg(-1) in anesthetized dogs and 10 mg in the heart-lung preparation, respectively, a positive inotropic effect of amantadine is observed. This effect is caused by a liberation of catecholamines. Higher dosage of amantadine decreases cardiac contractility significantly. Therefore the negative inotropic influence of the drug itself has to be distinguished from the indirect sympathomimetic effect resulting from local release of myocardial catecholamines. Cardiac arrhythmias which occur in several experiments, can mostly be eliminated with propranolol or other drugs like lidocaine or sparteinsulphate.

Published
1975

6. [Negative inotropic effects of hexobarbital, diphenylhydantoin, propanidid and chlormethiazole on the previously damaged heart (author's transl)].

Author

van Ackern K, Brückner UB, Deuster JE, Hoyer S, Mast GJ, Mittmann U, Schmidt HD, and Schmier J

Subjects
Animals, Child, Depression, Chemical, Dogs, Female, Heart physiopathology, Hemodynamics drug effects, Humans, Male, Middle Aged, Chlormethiazole pharmacology, Heart drug effects, Hexobarbital pharmacology, Phenytoin pharmacology, Propanidid pharmacology
Published
1973

7. [Acute reduction of contractility of the mammalian heart muscle by ketamine].

Author

van Ackern K, Deuster JE, and Mast GJ

Subjects
Animals, Blood Pressure drug effects, Calcium Chloride pharmacology, Cardiac Output drug effects, Cardiac Volume drug effects, Dogs, Female, Heart physiology, Heart Rate drug effects, Ketamine antagonists & inhibitors, Male, Strophanthins pharmacology, Heart drug effects, Hemodynamics drug effects, Ketamine pharmacology
Published
1972

8. Acute changes in adhesive platelet count and pulmonary hemodynamics in tourniquet shock of dogs.

Author

Van Ackern K, Brückner UB, Deuster JE, Leinberger H, and Schmier J

Subjects
Animals, Blood Pressure, Cardiac Output, Glass, Heart Rate, Heart Ventricles physiopathology, Ischemia, Lung blood supply, Pulmonary Artery physiology, Shock blood, Vascular Resistance, Blood Cell Count, Hemodynamics, Lung physiopathology, Platelet Adhesiveness, Shock physiopathology, Tourniquets
Published
1973
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