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29 results on '"Deus, Cláudia M."'

8. Investigating the impact of physical activity on mitochondrial function in Parkinson’s disease (PARKEX): Study protocol for a randomised controlled clinical trial

Author

Magaña, Juan Carlos, primary, Deus, Cláudia M., additional, Baldellou, Laura, additional, Avellanet, M, additional, Gea-Rodríguez, E, additional, Calzada, Silvia Enriquez, additional, Laguna, Ariadna, additional, Martínez-Vicente, Marta, additional, Hernández-Vara, Jorge, additional, Giné-Garriga, Maria, additional, Pereira, Susana P., additional, and Montané, Joel, additional

Published
2023
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11. List of contributors

Author

Abalo, Raquel, Abdollahi, Milad, Abu-Samak, Mahmoud S., Adi Pinandito, Yohanes Krisnantyo, Agnoletti, Bárbara Z., Aguilar-González, Miguel A., Aguilar, Cristóbal N., Agunloye, Odunayo M., Akaffou, Sélastique, Alegret, Marta, Alves, Rita C., Amir, Muhammad Subhan, Andrade, Nelson, Apetrei, Constantin, Aprigio, Nícollas Gabriel de Oliveira, Asil, Esma, Awwad, Shady H., Barbisan, Luís Fernando, Barreto-Peixoto, Juliana A., Basaran, Burhan, Bastos-Filho, Teodiano, Beccari, Fabio, Berti, Federico, Bezandry, Rickarlos, Binello, Arianna, Blanco-Díaz, Cristian Felipe, Bodur, Mahmut, Bounegru, Alexandra Virginia, Bramantoro, Taufan, Branco, Ana F., Brancucci, Alfredo, Büschgens, Luca, Budán, Ferenc, Buyukkurt, Ozlem Kilic, Bytof, Gerhard, Cadwallader, Keith R., Cao, Chao, Caprioli, Giovanni, Celedón, Juan C., Cervera-Mata, Ana, Cesarino, Igor, Chagas, Patrícia, Chemello, Diego, Chmurzynska, Agata, Christianty, Fransiska Maria, Chávez González, Mónica L., Coimbra, Manuel A., Conde, Silvia V., Coreta-Gomes, Filipe, Couturon, Emmanuel, Cravotto, Giancarlo, Crouzillat, Dominique, Damiri, Basma, Dash, Dillip Kumar, da Silva, Maria Alice Esteves, da Silva, Michelle Costa, da Silva Junior, Ademário Iris, Delatour, Thierry, Delgado, Gabriel, de Oliveira, Marcos Roberto, de Podestá, Olívia Perim Galvão, de Rezende, Claudia Moraes, Desai, Nivas, de Souza, Tassio da Silva, de Souza Costa, Arthur Merigueti, Deus, Cláudia M., Diaz-Gómez, Rallinari, Domingues, Douglas Silva, do Prado, Camila Bruneli, Duarte-Correa, Yudy, Dubois, Mathieu, Dupeyron, Mathilde, Elbadry, Abdullah M.M., Elsaadani, Moez, Elsaadani, Muhamed, Eshak, Ehab, Ewa, Lange, Ewelina, Pałkowska-Goździk, Fajrin, Fifteen Aprila, Farah, Adriana, Fathi, Faezeh, Fernandes, Patrícia, Fernández-Arteaga, Alejandro, Ferreira, Helena, Ferreira, Thiago, Ferreira, Júlia Rabelo Santos, Ferrão, Maria Amélia Gava, Forzato, Cristina, Francis, Akintoye O., Frank, Oliver, Freitas, Jair C.C., Fuentes, Eduardo, Fukasawa, Masayoshi, Gallego-Barceló, Paula, Galluzzi, Maria Letícia, Gamal, Nermin, Garcia, Sergio Britto, Gigl, Michael, Goh, Rui Min Vivian, Grimm, Marcus Otto Walter, Guclu, Gamze, Guercia, Elena, Guerrero-Méndez, Cristian David, Guyot, Romain, Halim-Lim, Sarina Abdul, Hamon, Perla, Hamon, Serge, Han, Yueh-Ying, Hegde, Shrilakshmi, Herrera-Jácome, Darío Fernando, Hoang, Minh Hao, Huang, Yunle, Huang, Dejian, Hyppönen, Elina, Irmalia, Wahyuning Ratih, Iso, Hiroyasu, Ivamoto-Suzuki, Suzana Tiemi, Janitschke, Daniel, Jaramillo-Isaza, Sebastián, Jazayeri, Seyed Mehdi, Jazayeri, Reyhaneh Sadat, Jia, Huijuan, Jublot, Lionel, Kalthoff, Sandra, Kannen, Vinicius, Kaviani, Mojtaba, Kelebek, Hasim, Khairnar, Amit, Khat-udomkiri, Nuntawat, Kleinwächter, Maik, Kouchaksaraee, Reza M., Krismariono, Agung, Kronschläger, Martin, Kulapichitr, Fareeya, Laguna, Juan Carlos, Lang, Roman, Lani, Mohd Nizam, Lauer, Anna Andrea, Li, Xuguang, Lip, Gregory Y.H., Liu, Shao Quan, Loja, Pedro Darío Cedeño, Lyu, Weida, Macedo Brand, Ana Laura, Machado, Fernanda, Machado, Marlene, Maheshwari, Rajesh A., Manippa, Valerio, Maqboul, Iyad, Marandi, Sayyed Mohammad, Marinho, Daniele Alves, Martel, Fátima, Martins, Cleodice Alves, Martins, Fátima O., Mattioli, Anna Vittoria, Mazzafera, Paulo, Mohammad, Beisan, Morejon, Karen Rafaela Mayorga, MotieGhader, Habib, Máthé, Domokos, Munde, Manojkumar K., Murillo, Ricardo Augusto Luna, Murthy, Pushpa S., Myo, Hla, Navarini, Luciano, Netto, Annibal Duarte Pereira, Nguyen, Linh Nham, Noormohammadi, Haniyeh, Nugraha, Alexander Patera, Oboh, Ganiyu, Ogawa, Motohiko, Oliveira, Emanuele C.S., Oliveira, M. Beatriz P.P., Oliveira, Paulo J., Orjuela-Cañón, Alvaro David, Osorio-Arias, Juan Camilo, Oussou, Kouame Fulbert, Padulo, Caterina, Palomo, Iván, Pastoriza, Silvia, Patel, Vinood B., Pedroso, Andressa Bressan, Peerapen, Paleerath, Pereira, Luiz Filipe Protasio, Pham, Kitty, Pires, Luciana Bicalho Cevolani, Preedy, Victor R., Pua, Aileen, Raharimala, Nathalie Eva, Raharimalala, Nathalie Eva, Rajendram, Rajkumar, Ray, Aratrika, Retnowati, Wiwin, Rodríguez, Lyanne, Roglans, Núria, Romualdo, Guilherme Ribeiro, Ruelas-Chacón, Xóchitl, Rufián-Henares, José Ángel, Ruiss, Manuel, Ruiz-Olaya, Andrés Felipe, Sacramento, Joana F., Sagratini, Gianni, Salari, Solmaz, Salaroli, Luciane Bresciani, Sandoval-Cortes, José, Santanatoglia, Agnese, Santiago, Carmen, Sardão, Vilma A., Scherer, Rodrigo, Selli, Serkan, Selmar, Dirk, Sen, Dhanya B., Sen, Ashim Kumar, Sepúlveda, Magdalena, Shah, Jigna S., Sharma, Nishant, Shi, Xuan-Zheng, Shidqi, Alfisar, Shirkhani, Samaneh, Shooshtari, Maryam Sadat Beheshti, Smrke, Samo, Soni, Ritu, Sík, Attila, Strassburg, Christian P., Surma, Stanisław, Szabó, László, Szentpéteri, József L., Szép, Dávid, Tagliapietra, Silvia, Tanokura, Masaru, Tellería, Francisca, Teramoto, Masayuki, Theurillat, Viviane, Thongboonkerd, Visith, İlhan-Esgin, Merve, Torres-Valenzuela, Laura Sofia, Özbek, Yağmur Demirel, Valente, Letícia Cardoso, Villamar-Torres, Ronald Oswaldo, Vittori, Sauro, Vo, Thi Nga, Wan-Mohtar, Wan Abd Al Qadr Imad, Wang, Ruixuan, Wei, Feifei, Wirths, Oliver, Yang, Lin, Yeretzian, Chahan, Yılmaz, Mustafa Volkan, Yu, Bin, Zanin, Rodolfo Campos, Zidan, Thabet, and Zulfiana, Amalia Ayu

Published
2025
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20. SULFATION PATHWAYS: Potential benefits of a sulfated resveratrol derivative for topical application

Author

Correia-da-Silva, Marta, primary, Rocha, Verónica, additional, Marques, Cláudia, additional, Deus, Cláudia M, additional, Marques-Carvalho, Adriana, additional, Oliveira, Paulo J, additional, Palmeira, Andreia, additional, Pinto, Madalena, additional, Sousa, Emília, additional, Sousa Lobo, José Manuel, additional, and Almeida, Isabel Filipa, additional

Published
2018
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27. Protective Effect of Green Tea (Camellia sinensis (L.) Kuntze) against Prostate Cancer: From In Vitro Data to Algerian Patients.

Author

Lassed, Somia, Deus, Cláudia M., Djebbari, Radja, Zama, Djamila, Oliveira, Paulo J., Rizvanov, Albert A., Dahdouh, Abderrezak, Benayache, Fadila, and Benayache, Samir

Subjects
*THERAPEUTIC use of antioxidants, *ERYTHROCYTE metabolism, *ANTIOXIDANT analysis, *BIOMARKERS, *IN vitro studies, *GLUTATHIONE, *FLAVONOIDS, *CARCINOGENESIS, *CASE-control method, *GREEN tea, *OXIDATIVE stress, *CANCER patients, *MALONDIALDEHYDE, *ALGERIANS, *CELL lines, *PROSTATE tumors, *PHENOTYPES
Abstract

Green tea (GT) has been studied for its effects as antioxidant and cancer-preventive agent. Epidemiological studies showed that GT consumption decreases the risk for prostate cancer (PC). To investigate whether erythrocyte oxidative stress (OS) is associated with PC and whether daily consumption of GT improves the oxidative phenotype, we performed a study in a group of Algerian PC patients, preceded by an in vitro study to characterize composition and antioxidant/antiproliferative activities of the GT used. This contained a high content of phenolic and flavonoid compounds, demonstrating in vitro antioxidant activity and significant antiproliferative effect on human prostate cancer PC-3 cell line. Seventy PC patients and 120 age-matched healthy subjects participated in the study, with glutathione (GSH), malondialdehyde (MDA), and catalase activity evaluated before and after GT consumption. The results showed a reduced GSH and catalase activity and a high level of MDA in erythrocytes from PC patients. The consumption of 2-3 cups per day of GT during 6 months significantly increased GSH concentration and catalase activity and decreased MDA concentration. In conclusion, GT significantly decreased OS in Algerian PC patients. Regular consumption of GT for a long period may prevent men from developing PC or at least delay its progression. [ABSTRACT FROM AUTHOR]

Published
2017
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28. Shutting Down the Furnace: Preferential Killing of Cancer Cells with Mitochondrial-Targeting Molecules

Author

Deus, Cláudia M., Santos, Gabriela L., Loureiro, Rute, Vega-Naredo, Ignacio, Faneca, Henrique, and Oliveira, Paulo J.

Abstract

Mitochondria are organelles which play an important role not only in cellular metabolism but also in controlling pathways related with cell death, ionic and redox regulation. Alterations in mitochondrial metabolism are implicated in a variety of diseases, including cancer. Cellular and mitochondrial metabolism are both altered during the different stages of tumor development. As cancer cells have altered metabolic profiles, these alterations are a valid and promising target for anti-cancer agents. We hereby review several molecules that are in different stages of development and which target mitochondria in cancer cells. However, not all compounds are efficiently delivered into mitochondria, especially due to the difficulty of these agents to cross the membranes that surround the organelle, contributing to a loss of effectiveness and specificity. This led to the development of effective strategies aimed at delivering useful cargo to mitochondria, including the use of delocalized lipophilic cations coupled to useful molecules, or peptides that insert in mitochondrial membranes. Although several of those targeting strategies have still a very limited use against cancer cells, we present here the advantages and disadvantages of each combination.

Published
2015

29. Potential benefits of a sulfated resveratrol derivative for topical application.

Author

Correia-da-Silva, Marta, Rocha, Verónica, Marques, Cláudia, Deus, Cláudia M., Marques-Carvalho, Adriana, SOliveira, Paulo J., Palmeira, Andreia, Pinto, Madalena, Sousa, Emília, Sousa Lobo, José Manuel, and Almeida, Isabel Filipa

Subjects
*RESVERATROL, *ANTI-inflammatory agents, *CELL-mediated cytotoxicity, *WESTERN immunoblotting, *OXIDATIVE stress, *POLYPHENOLS
Abstract

Resveratrol (RSV) is a polyphenolic compound with antioxidant, anti-inflammatory and anti-aging properties partly associated with sirtuin 1 (SIRT1)-activation in the skin. However, poor water solubility may limit RSV efficacy. This work aimed to clarify the interest of a new synthetic water-soluble RSV derivative (resveratrol glucoside sulfate, RSV-GS) for topical application. Resveratrol glucoside sulfate was synthesized using microwave-assisted sulfation. Cytotoxicity assays were performed with the keratinocyte HaCaT cell line, using MTT reduction, neutral red uptake, Alamar Blue/resazurin reduction, trypan blue exclusion and measurement of ATP concentration. Western blotting was used to evaluate SIRT1 protein content. Regarding SIRT1 binding, an in silico docking study was performed, using AutoDock Vina. Our results showed that the synthetic derivative RSV-GS was 1000 times more soluble in water than RSV and its non-sulfated glucoside. No relevant decrease in HaCaT cell viability was observed for concentrations up to 5 mM for RSV-GS, and up to 500 μM for resveratrol glucoside, while a significant decrease in HaCaT viability occurred from 100 μM for RSV. RSV-GS and RSV showed a similar behavior regarding protective effect against oxidative stress-induced cytotoxicity. SIRT1 protein content increased after treatment with 500 μM of RSV-GS and 100 μM of RSV. Moreover, in silico studies predicted that RSV-GS binds more stably to SIRT1 with a lower binding free energy than RSV. Although these results support the possible use of RSV-GS in topical formulations, in vivo safety and efficacy studies are needed before considering the use of RSV-GS in commercial products. [ABSTRACT FROM AUTHOR]

Published
2018
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