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Die Demenz mit Lewykorperchen (DLB) ist die zweithaufigste neurodegenerative Demenz nach der Alzheimer-Erkrankung. Sie ist gerade im fruhen Krankheitsstadium durch besondere Symptomkonstellationen und Reaktionen auf Medikamente gekennzeichnet und muss bei der Demenzabklarung in die differenzialdiagnostischen Uberlegungen eingeschlossen werden.

Eine Studie untersuchte das Risiko einer Alzheimer-Erkrankung in Abhangigkeit vom Benzodiazepin-Gebrauch. Nicht nur wegen dieses Zusammenhangs ist die Indikation von Benzodiazepinen sehr kritisch zu stellen.

The pattern of recurrent pathways from motor axon collaterals to motoneurones has been investigated in the spinal cord of anaesthetized cats with intracellular techniques. Only recurrent inhibitory postsynaptic potentials (RIPSPs) were observed so far. They were very pronounced between the mechanical synergists acting at the elbow. The triceps muscles received substantial effects also from the extensor carpi ulnaris (ECU) and from palmar-located medialis (M) and ulnaris (U1) muscles. The effects were much smaller in the motor nuclei acting on the wrist (ECU, EC radialis (ECR)). The motor nuclei to the muscles acting on the phalanges (extensor digitorum communis and lateralis, extensor indicis proprius, and abductor pollicis longus (EDC, EDL, EIP, APL)) neither received nor emitted any recurrent effects, which may indicate a lack of the recurrent system in these distal motor nuclei. A comparison of the recurrent pattern with the distribution of monosynaptic excitation from large muscles spindle afferents (Ia) shows that there is a partial overlap of both systems only at the elbow joint.